BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 45073 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1)c1ccccc1 InChI=1S/C21H20N4/c1-15(17-9-5-3-6-10-17)23-21-13-20-19(14-22-21)16(2)24-25(20)18-11-7-4-8-12-18/h3-15H,1-2H3,(H,22,23)/t15-/m0/s1 DJNPBANWRKSHQM-HNNXBMFYSA-N 24925 3-methyl-1-phenyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::BMCL185648 Compound 1::pyrazolopyridine-based compound, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 1301 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24925&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971414 56269876 ZINC40918055 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45074 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C21H19ClN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1 NTAIRXFACXVUQO-AWEZNQCLSA-N 24926 1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::BMCL185648 Compound 15::pyrazolopyridine-based compound, 2 Serine/threonine-protein kinase PLK1 Homo sapiens 121 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24926&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971415 56269877 ZINC40918210 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45075 C[C@H](Nc1cc2c(noc2cn1)-c1ccccc1)c1ccccc1 InChI=1S/C20H17N3O/c1-14(15-8-4-2-5-9-15)22-19-12-17-18(13-21-19)24-23-20(17)16-10-6-3-7-11-16/h2-14H,1H3,(H,21,22)/t14-/m0/s1 RLARTPHANIERPF-AWEZNQCLSA-N 24927 2-amino-isoxazolopyridine, 3::3-phenyl-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 1616 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24927&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971416 56269878 ZINC40845375 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45076 C[C@H](Nc1cc2c(noc2cn1)-c1cccc(C)c1)c1ccccc1 InChI=1S/C21H19N3O/c1-14-7-6-10-17(11-14)21-18-12-20(22-13-19(18)25-24-21)23-15(2)16-8-4-3-5-9-16/h3-13,15H,1-2H3,(H,22,23)/t15-/m0/s1 RMKFZACOOVWLAE-HNNXBMFYSA-N 24928 2-amino-isoxazolopyridine, 4::3-(3-methylphenyl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 549 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24928&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971417 56269879 ZINC40951784 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45077 C[C@H](Nc1cc2c(noc2cn1)-c1ccc(C)cc1)c1ccccc1 InChI=1S/C21H19N3O/c1-14-8-10-17(11-9-14)21-18-12-20(22-13-19(18)25-24-21)23-15(2)16-6-4-3-5-7-16/h3-13,15H,1-2H3,(H,22,23)/t15-/m0/s1 OKIPMNUDSPZOMT-HNNXBMFYSA-N 24929 2-amino-isoxazolopyridine, 5::3-(4-methylphenyl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 1170 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24929&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971418 56269880 ZINC40951785 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45078 C[C@H](Nc1cc2c(noc2cn1)-c1cc(C)cc(C)c1)c1ccccc1 InChI=1S/C22H21N3O/c1-14-9-15(2)11-18(10-14)22-19-12-21(23-13-20(19)26-25-22)24-16(3)17-7-5-4-6-8-17/h4-13,16H,1-3H3,(H,23,24)/t16-/m0/s1 CYRHCHWHTHQZAV-INIZCTEOSA-N 24930 2-amino-isoxazolopyridine, 6::3-(3,5-dimethylphenyl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 330 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971419 56269881 ZINC40423461 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45079 C[C@H](Nc1cc2c(noc2cn1)-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C20H16ClN3O/c1-13(14-6-3-2-4-7-14)23-19-11-17-18(12-22-19)25-24-20(17)15-8-5-9-16(21)10-15/h2-13H,1H3,(H,22,23)/t13-/m0/s1 CQYPOADQLJEUBB-ZDUSSCGKSA-N 24931 2-amino-isoxazolopyridine, 7::3-(3-chlorophenyl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 625 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971420 56269882 ZINC40421662 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45080 COc1ccc(cc1OC)-c1noc2cnc(N[C@@H](C)c3ccccc3)cc12 InChI=1S/C22H21N3O3/c1-14(15-7-5-4-6-8-15)24-21-12-17-20(13-23-21)28-25-22(17)16-9-10-18(26-2)19(11-16)27-3/h4-14H,1-3H3,(H,23,24)/t14-/m0/s1 IDWMLMNMILZSML-AWEZNQCLSA-N 24932 2-amino-isoxazolopyridine, 8::3-(3,4-dimethoxyphenyl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 4927 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971421 56269883 ZINC45498733 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45081 C[C@H](Nc1cc2c(noc2cn1)-c1ccc2OCOc2c1)c1ccccc1 InChI=1S/C21H17N3O3/c1-13(14-5-3-2-4-6-14)23-20-10-16-19(11-22-20)27-24-21(16)15-7-8-17-18(9-15)26-12-25-17/h2-11,13H,12H2,1H3,(H,22,23)/t13-/m0/s1 DAAGOCSHXCDWDY-ZDUSSCGKSA-N 24933 2-amino-isoxazolopyridine, 9::3-(2H-1,3-benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 214 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24933&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971422 56269884 ZINC40424450 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45082 C[C@H](Nc1cc2c(noc2cn1)-c1cc(Cl)cc(CCCO)c1)c1ccccc1 InChI=1S/C23H22ClN3O2/c1-15(17-7-3-2-4-8-17)26-22-13-20-21(14-25-22)29-27-23(20)18-10-16(6-5-9-28)11-19(24)12-18/h2-4,7-8,10-15,28H,5-6,9H2,1H3,(H,25,26)/t15-/m0/s1 MMGKIHLBFPJYJL-HNNXBMFYSA-N 24934 2-amino-isoxazolopyridine, 13::3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}pyrido[4,3-d][1,2]oxazol-3-yl)phenyl]propan-1-ol Serine/threonine-protein kinase PLK1 Homo sapiens 99 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24934&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1FR 3DB8 24941248 56269885 DB06897 ZINC34285229 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45083 C[C@H](Nc1cc2c(noc2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1 InChI=1S/C23H21ClN4O2/c1-14(16-5-3-2-4-6-16)27-22-12-19-20(13-26-22)30-28-23(19)17-9-15(7-8-21(25)29)10-18(24)11-17/h2-6,9-14H,7-8H2,1H3,(H2,25,29)(H,26,27)/t14-/m0/s1 KVJXBCZPOFTDAU-AWEZNQCLSA-N 24935 2-amino-isoxazolopyridine, 15::3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}pyrido[4,3-d][1,2]oxazol-3-yl)phenyl]propanamide Serine/threonine-protein kinase PLK1 Homo sapiens 51 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24935&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971423 56269886 ZINC40951123 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45084 C[C@H](Nc1cc2c(Cc3ccccc3)noc2cn1)c1ccccc1 InChI=1S/C21H19N3O/c1-15(17-10-6-3-7-11-17)23-21-13-18-19(24-25-20(18)14-22-21)12-16-8-4-2-5-9-16/h2-11,13-15H,12H2,1H3,(H,22,23)/t15-/m0/s1 BOJMKEOOGVQEAQ-HNNXBMFYSA-N 24936 2-amino-isoxazolopyridine, 18::3-benzyl-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24936&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971424 56269887 ZINC40951126 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45085 C[C@H](Nc1cc2c(noc2cn1)-c1cccs1)c1ccccc1 InChI=1S/C18H15N3OS/c1-12(13-6-3-2-4-7-13)20-17-10-14-15(11-19-17)22-21-18(14)16-8-5-9-23-16/h2-12H,1H3,(H,19,20)/t12-/m0/s1 HMLWZSKONNDQRL-LBPRGKRZSA-N 24937 2-amino-isoxazolopyridine, 19::N-[(1S)-1-phenylethyl]-3-(thiophen-2-yl)pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 3007 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24937&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971425 56269888 ZINC45505796 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45086 C[C@H](Nc1cc2c(noc2cn1)-c1cscc1C)c1ccccc1 InChI=1S/C19H17N3OS/c1-12-10-24-11-16(12)19-15-8-18(20-9-17(15)23-22-19)21-13(2)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,20,21)/t13-/m0/s1 QNYZHMLWZSRWRH-ZDUSSCGKSA-N 24938 2-amino-isoxazolopyridine, 20::3-(4-methylthiophen-3-yl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 779 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24938&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971426 56269889 ZINC40423539 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45087 C[C@H](Nc1cc2c(noc2cn1)C1CCCCC1C)c1ccccc1 InChI=1S/C21H25N3O/c1-14-8-6-7-11-17(14)21-18-12-20(22-13-19(18)25-24-21)23-15(2)16-9-4-3-5-10-16/h3-5,9-10,12-15,17H,6-8,11H2,1-2H3,(H,22,23)/t14?,15-,17?/m0/s1 RRBCORZOVOSGLG-CKDBGZEDSA-N 24939 2-amino-isoxazolopyridine, 21::3-(2-methylcyclohexyl)-N-[(1S)-1-phenylethyl]pyrido[4,3-d][1,2]oxazol-5-amine Serine/threonine-protein kinase PLK1 Homo sapiens 5689 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24939&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971427 56269890 ZINC45506066 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45088 C[C@H](Nc1cc2c(noc2cn1)C1CCCN(CCC(N)=O)C1)c1ccccc1 InChI=1S/C22H27N5O2/c1-15(16-6-3-2-4-7-16)25-21-12-18-19(13-24-21)29-26-22(18)17-8-5-10-27(14-17)11-9-20(23)28/h2-4,6-7,12-13,15,17H,5,8-11,14H2,1H3,(H2,23,28)(H,24,25)/t15-,17?/m0/s1 ZOIMQOAMAULHEL-MYJWUSKBSA-N 24940 2-amino-isoxazolopyridine, 23::3-[3-(5-{[(1S)-1-phenylethyl]amino}pyrido[4,3-d][1,2]oxazol-3-yl)piperidin-1-yl]propanamide Serine/threonine-protein kinase PLK1 Homo sapiens 7479 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.091 10.7270/Q22Z13T8 18790636 aid1798481 Hanan, EJ; Fucini, RV; Romanowski, MJ; Elling, RA; Lew, W; Purkey, HE; VanderPorten, EC; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24940&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971428 56269891 ZINC40423844 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 48401 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 8.0 7.5 22.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00594.x 10.7270/Q2T151Z8 18005335 aid1798697 Kothe, M; Kohls, D; Low, S; Coli, R; Rennie, GR; Feru, F; Kuhn, C; Ding, YH Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 48402 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C27H37N7O2/c1-4-22-26(36)33(3)23-17-28-27(31-24(23)34(22)21-7-5-6-8-21)30-19-11-9-18(10-12-19)25(35)29-20-13-15-32(2)16-14-20/h9-12,17,20-22H,4-8,13-16H2,1-3H3,(H,29,35)(H,28,30,31)/t22-/m1/s1 MOIBHLHUAXJLCW-JOCHJYFZSA-N 26514 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-N-(1-methylpiperidin-4-yl)benzamide::BI 2536 analogue, 1b Serine/threonine-protein kinase PLK1 Homo sapiens 5.0 7.5 22.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00594.x 10.7270/Q2T151Z8 18005335 aid1798697 Kothe, M; Kohls, D; Low, S; Coli, R; Rennie, GR; Feru, F; Kuhn, C; Ding, YH Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26514&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11511524 56464951 ZINC03986141 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 48403 COc1cc(ccc1Nc1ncc(C(C)=O)c(NC2CCCC2)n1)N1CCN(C)CC1 InChI=1S/C23H32N6O2/c1-16(30)19-15-24-23(27-22(19)25-17-6-4-5-7-17)26-20-9-8-18(14-21(20)31-3)29-12-10-28(2)11-13-29/h8-9,14-15,17H,4-7,10-13H2,1-3H3,(H2,24,25,26,27) RLQUSJKLICEKBP-UHFFFAOYSA-N 26515 1-[4-(cyclopentylamino)-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl]ethan-1-one::BI 2536 analogue, 2a Serine/threonine-protein kinase PLK1 Homo sapiens 145.3 7.5 22.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00594.x 10.7270/Q2T151Z8 18005335 aid1798697 Kothe, M; Kohls, D; Low, S; Coli, R; Rennie, GR; Feru, F; Kuhn, C; Ding, YH Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26515&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25138220 56464952 ZINC62233014 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 48404 CN1CCN(CC1)c1ccc(Nc2ncc(C(C)=O)c(NC3CCCC3)n2)cc1 InChI=1S/C22H30N6O/c1-16(29)20-15-23-22(26-21(20)24-17-5-3-4-6-17)25-18-7-9-19(10-8-18)28-13-11-27(2)12-14-28/h7-10,15,17H,3-6,11-14H2,1-2H3,(H2,23,24,25,26) JXEFOTNVTVZSOF-UHFFFAOYSA-N 26516 1-[4-(cyclopentylamino)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl]ethan-1-one::BI 2536 analogue, 2b Serine/threonine-protein kinase PLK1 Homo sapiens 345.3 7.5 22.00 C Curated from the literature by BindingDB 10.1111/j.1747-0285.2007.00594.x 10.7270/Q2T151Z8 18005335 aid1798697 Kothe, M; Kohls, D; Low, S; Coli, R; Rennie, GR; Feru, F; Kuhn, C; Ding, YH Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26516&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25138221 56464953 ZINC62233020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46223 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1)c1ccccc1 InChI=1S/C21H20N4/c1-15(17-9-5-3-6-10-17)23-21-13-20-19(14-22-21)16(2)24-25(20)18-11-7-4-8-12-18/h3-15H,1-2H3,(H,22,23)/t15-/m0/s1 DJNPBANWRKSHQM-HNNXBMFYSA-N 24925 3-methyl-1-phenyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::BMCL185648 Compound 1::pyrazolopyridine-based compound, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 1301 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24925&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971414 56269876 ZINC40918055 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46224 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1C)c1ccccc1 InChI=1S/C22H22N4/c1-15-9-7-8-12-20(15)26-21-13-22(23-14-19(21)17(3)25-26)24-16(2)18-10-5-4-6-11-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1 LLHUMXQCBQCMPT-INIZCTEOSA-N 25501 2-amino-pyrazolopyridine, 6::3-methyl-1-(2-methylphenyl)-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine Serine/threonine-protein kinase PLK1 Homo sapiens 7685 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25501&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093244 56412791 ZINC40424303 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46225 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(C)c1)c1ccccc1 InChI=1S/C22H22N4/c1-15-8-7-11-19(12-15)26-21-13-22(23-14-20(21)17(3)25-26)24-16(2)18-9-5-4-6-10-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1 MLMXKZMBMJSSRG-INIZCTEOSA-N 25502 2-amino-pyrazolopyridine, 7::3-methyl-1-(3-methylphenyl)-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine Serine/threonine-protein kinase PLK1 Homo sapiens 474 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25502&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093245 56412792 ZINC40976770 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46226 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccc(C)cc1)c1ccccc1 InChI=1S/C22H22N4/c1-15-9-11-19(12-10-15)26-21-13-22(23-14-20(21)17(3)25-26)24-16(2)18-7-5-4-6-8-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1 YEYMEYADLLVKGI-INIZCTEOSA-N 25503 2-amino-pyrazolopyridine, 8::3-methyl-1-(4-methylphenyl)-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine Serine/threonine-protein kinase PLK1 Homo sapiens 4528 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25503&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093246 56412793 ZINC40428699 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46227 COc1ccccc1-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12 InChI=1S/C22H22N4O/c1-15(17-9-5-4-6-10-17)24-22-13-20-18(14-23-22)16(2)25-26(20)19-11-7-8-12-21(19)27-3/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1 PHLAPDHHLBMRBX-HNNXBMFYSA-N 25504 1-(2-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 9 Serine/threonine-protein kinase PLK1 Homo sapiens 14451 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25504&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093247 56412794 ZINC40976772 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46228 COc1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12 InChI=1S/C22H22N4O/c1-15(17-8-5-4-6-9-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-10-7-11-19(12-18)27-3/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1 AVCWXYCDBRFSPG-HNNXBMFYSA-N 25505 1-(3-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 10 Serine/threonine-protein kinase PLK1 Homo sapiens 5928 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25505&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093248 56412795 ZINC40953093 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46229 COc1ccc(cc1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12 InChI=1S/C22H22N4O/c1-15(17-7-5-4-6-8-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-9-11-19(27-3)12-10-18/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1 CZNFERGZXNXTAS-HNNXBMFYSA-N 25506 1-(4-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 11 Serine/threonine-protein kinase PLK1 Homo sapiens 703 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25506&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093249 56412796 ZINC40953095 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46230 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1F)c1ccccc1 InChI=1S/C21H19FN4/c1-14(16-8-4-3-5-9-16)24-21-12-20-17(13-23-21)15(2)25-26(20)19-11-7-6-10-18(19)22/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1 DQZJBCXRJVKIME-AWEZNQCLSA-N 25507 1-(2-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 12 Serine/threonine-protein kinase PLK1 Homo sapiens 4516 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25507&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093250 56412797 ZINC40957761 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46231 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(F)c1)c1ccccc1 InChI=1S/C21H19FN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1 QODLEHFRJKWYRL-AWEZNQCLSA-N 25508 1-(3-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 13 Serine/threonine-protein kinase PLK1 Homo sapiens 464 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25508&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093251 56412798 ZINC40957763 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46232 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccc(F)cc1)c1ccccc1 InChI=1S/C21H19FN4/c1-14(16-6-4-3-5-7-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-8-17(22)9-11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1 LBPLOTUSSSOCHO-AWEZNQCLSA-N 25509 1-(4-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 14 Serine/threonine-protein kinase PLK1 Homo sapiens 3241 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25509&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093252 56412799 ZINC40973118 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46233 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C21H19ClN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1 NTAIRXFACXVUQO-AWEZNQCLSA-N 24926 1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::BMCL185648 Compound 15::pyrazolopyridine-based compound, 2 Serine/threonine-protein kinase PLK1 Homo sapiens 121 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24926&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24971415 56269877 ZINC40918210 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46234 CC(C)c1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12 InChI=1S/C24H26N4/c1-16(2)20-11-8-12-21(13-20)28-23-14-24(25-15-22(23)18(4)27-28)26-17(3)19-9-6-5-7-10-19/h5-17H,1-4H3,(H,25,26)/t17-/m0/s1 KJXJPUPIAYZGOR-KRWDZBQOSA-N 25510 2-amino-pyrazolopyridine, 16::3-methyl-N-[(1S)-1-phenylethyl]-1-[3-(propan-2-yl)phenyl]-1H-pyrazolo[4,3-c]pyridin-6-amine Serine/threonine-protein kinase PLK1 Homo sapiens 1476 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25510&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093253 56412800 ZINC40949396 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46235 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)C#N)c1ccccc1 InChI=1S/C22H19N5/c1-15(18-8-4-3-5-9-18)25-22-12-21-20(14-24-22)16(2)26-27(21)19-10-6-7-17(11-19)13-23/h3-12,14-15H,1-2H3,(H,24,25)/t15-/m0/s1 BVODXCQNNKPJJA-HNNXBMFYSA-N 25511 2-amino-pyrazolopyridine, 17::3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)benzonitrile Serine/threonine-protein kinase PLK1 Homo sapiens 412 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25511&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093254 56412801 ZINC40845171 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46236 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)N(C)C)c1ccccc1 InChI=1S/C23H25N5/c1-16(18-9-6-5-7-10-18)25-23-14-22-21(15-24-23)17(2)26-28(22)20-12-8-11-19(13-20)27(3)4/h5-16H,1-4H3,(H,24,25)/t16-/m0/s1 YBCXNIYSNJHIKZ-INIZCTEOSA-N 25512 1-[3-(dimethylamino)phenyl]-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 18 Serine/threonine-protein kinase PLK1 Homo sapiens 977 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25512&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093255 56412802 ZINC45506501 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46237 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)S(C)(=O)=O)c1ccccc1 InChI=1S/C22H22N4O2S/c1-15(17-8-5-4-6-9-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-10-7-11-19(12-18)29(3,27)28/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1 FPYKYTAARCRYBS-HNNXBMFYSA-N 25513 1-(3-methanesulfonylphenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 19 Serine/threonine-protein kinase PLK1 Homo sapiens 225 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25513&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093256 56412803 ZINC40938526 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46238 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(C)cc(C)c1)c1ccccc1 InChI=1S/C23H24N4/c1-15-10-16(2)12-20(11-15)27-22-13-23(24-14-21(22)18(4)26-27)25-17(3)19-8-6-5-7-9-19/h5-14,17H,1-4H3,(H,24,25)/t17-/m0/s1 APLADIXDVQYNTR-KRWDZBQOSA-N 25514 1-(3,5-dimethylphenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 20 Serine/threonine-protein kinase PLK1 Homo sapiens 149 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25514&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093257 56412804 ZINC40938528 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46239 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(Cl)c1)c1ccccc1 InChI=1S/C21H18Cl2N4/c1-13(15-6-4-3-5-7-15)25-21-11-20-19(12-24-21)14(2)26-27(20)18-9-16(22)8-17(23)10-18/h3-13H,1-2H3,(H,24,25)/t13-/m0/s1 ZPZIHCYPRUTMCK-ZDUSSCGKSA-N 25515 1-(3,5-dichlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 21 Serine/threonine-protein kinase PLK1 Homo sapiens 641 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25515&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093258 56412805 ZINC40936823 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46240 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(Br)c1)c1ccccc1 InChI=1S/C21H18BrClN4/c1-13(15-6-4-3-5-7-15)25-21-11-20-19(12-24-21)14(2)26-27(20)18-9-16(22)8-17(23)10-18/h3-13H,1-2H3,(H,24,25)/t13-/m0/s1 IQCGVYULCXCSLD-ZDUSSCGKSA-N 25516 1-(3-bromo-5-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 22 Serine/threonine-protein kinase PLK1 Homo sapiens 274 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25516&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093259 56412806 ZINC40420290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46241 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(O)=O)c1)c1ccccc1 InChI=1S/C24H23ClN4O2/c1-15(18-6-4-3-5-7-18)27-23-13-22-21(14-26-23)16(2)28-29(22)20-11-17(8-9-24(30)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H,26,27)(H,30,31)/t15-/m0/s1 JZZXVHOSYLFGAM-HNNXBMFYSA-N 25517 2-amino-pyrazolopyridine, 28::3-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanoic acid Serine/threonine-protein kinase PLK1 Homo sapiens 21 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25517&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093260 56412807 ZINC45484242 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46242 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1 InChI=1S/C24H24ClN5O/c1-15(18-6-4-3-5-7-18)28-24-13-22-21(14-27-24)16(2)29-30(22)20-11-17(8-9-23(26)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H2,26,31)(H,27,28)/t15-/m0/s1 SQRHNUCMJHZAKJ-HNNXBMFYSA-N 25518 2-amino-pyrazolopyridine, 29::3-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide Serine/threonine-protein kinase PLK1 Homo sapiens 32 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25518&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093261 56412808 ZINC40973376 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46243 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(=O)NCCO)c1)c1ccccc1 InChI=1S/C26H28ClN5O2/c1-17(20-6-4-3-5-7-20)30-25-15-24-23(16-29-25)18(2)31-32(24)22-13-19(12-21(27)14-22)8-9-26(34)28-10-11-33/h3-7,12-17,33H,8-11H2,1-2H3,(H,28,34)(H,29,30)/t17-/m0/s1 VDGVHPMRIRMMNM-KRWDZBQOSA-N 25519 2-amino-pyrazolopyridine, 30::3-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]-N-(2-hydroxyethyl)propanamide Serine/threonine-protein kinase PLK1 Homo sapiens 48 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25519&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093262 56412809 C04080 ZINC40430048 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46244 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCCN)c1)c1ccccc1 InChI=1S/C24H26ClN5/c1-16(19-8-4-3-5-9-19)28-24-14-23-22(15-27-24)17(2)29-30(23)21-12-18(7-6-10-26)11-20(25)13-21/h3-5,8-9,11-16H,6-7,10,26H2,1-2H3,(H,27,28)/t16-/m0/s1 UFNNRSRJIBQSIO-INIZCTEOSA-N 25520 1-[3-(3-aminopropyl)-5-chlorophenyl]-3-methyl-N-[(1S)-1-phenylethyl]-1H-pyrazolo[4,3-c]pyridin-6-amine::2-amino-pyrazolopyridine, 36 Serine/threonine-protein kinase PLK1 Homo sapiens 59 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25520&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093263 56412810 ZINC40973378 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46245 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1 InChI=1S/C29H26ClN5O/c1-18(21-9-5-4-6-10-21)32-29-16-28-26(17-31-29)19(2)34-35(28)24-14-22(13-23(30)15-24)25-11-7-8-12-27(25)33-20(3)36/h4-18H,1-3H3,(H,31,32)(H,33,36)/t18-/m0/s1 QUYZXRAAIRZUEE-SFHVURJKSA-N 25521 2-amino-pyrazolopyridine, 37::N-{2-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]phenyl}acetamide Serine/threonine-protein kinase PLK1 Homo sapiens 207 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25521&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093264 56412811 ZINC40973281 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46246 C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1C(N)=O)c1ccccc1 InChI=1S/C28H24ClN5O/c1-17(19-8-4-3-5-9-19)32-27-15-26-25(16-31-27)18(2)33-34(26)22-13-20(12-21(29)14-22)23-10-6-7-11-24(23)28(30)35/h3-17H,1-2H3,(H2,30,35)(H,31,32)/t17-/m0/s1 IFCBXJXWEYHVPY-KRWDZBQOSA-N 25522 2-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]benzamide::2-amino-pyrazolopyridine, 38 Serine/threonine-protein kinase PLK1 Homo sapiens 42 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25522&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3FR 3DBD 24941250 56412812 ZINC34285228 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 46247 C[C@H](Nc1cc2n(ncc2cn1)-c1cc(Cl)cc(c1)-c1ccccc1C(N)=O)c1ccccc1 InChI=1S/C27H22ClN5O/c1-17(18-7-3-2-4-8-18)32-26-14-25-20(15-30-26)16-31-33(25)22-12-19(11-21(28)13-22)23-9-5-6-10-24(23)27(29)34/h2-17H,1H3,(H2,29,34)(H,30,32)/t17-/m0/s1 ARWOPUQEWAIZHZ-KRWDZBQOSA-N 25523 2-[3-chloro-5-(6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]benzamide::2-amino-pyrazolopyridine, 39 Serine/threonine-protein kinase PLK1 Homo sapiens 50 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.08.095 10.7270/Q29C6VRP 18793847 aid1798563 Fucini, RV; Hanan, EJ; Romanowski, MJ; Elling, RA; Lew, W; Barr, KJ; Zhu, J; Yoburn, JC; Liu, Y; Fahr, BT; Fan, J; Lu, Y; Pham, P; Choong, IC; VanderPorten, EC; Bui, M; Purkey, HE; Evanchik, MJ; Yang, W Sunesis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25523&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25093265 56412813 ZINC62154055 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45290 CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) DTEKTGDVSARYDS-UHFFFAOYSA-N 25017 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-5,6,7,8-tetrahydropteridin-6-one::BI-D1870 Serine/threonine-protein kinase PLK1 Homo sapiens 100 Curated from the literature by BindingDB 10.1042/BJ20061088 10.7270/Q25Q4TD7 17040210 aid1798500 Sapkota, GP; Cummings, L; Newell, FS; Armstrong, C; Bain, J; Frodin, M; Grauert, M; Hoffmann, M; Schnapp, G; Steegmaier, M; Cohen, P; Alessi, DR University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 584 5WIK,5D9K,7N7L 25023738 56374161 ZINC33359423 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45438 Nc1ccc(cc1)-c1csc2ncnc(N)c12 InChI=1S/C12H10N4S/c13-8-3-1-7(2-4-8)9-5-17-12-10(9)11(14)15-6-16-12/h1-6H,13H2,(H2,14,15,16) HKNAOIMDZKNBSU-UHFFFAOYSA-N 25113 5-(4-aminophenyl)thieno[2,3-d]pyrimidin-4-amine::thienopyrimidine analogue, 1 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25113&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25023774 56374255 ZINC62154051 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45439 Nc1ncnc2scc(-c3ccc(NC(=O)c4ccccc4)cc3)c12 InChI=1S/C19H14N4OS/c20-17-16-15(10-25-19(16)22-11-21-17)12-6-8-14(9-7-12)23-18(24)13-4-2-1-3-5-13/h1-11H,(H,23,24)(H2,20,21,22) LEOUBHRICJROPC-UHFFFAOYSA-N 25114 N-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)benzamide::thienopyrimidine analogue, 2 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25114&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25023775 56374256 ZINC62154052 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45440 Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1 InChI=1S/C20H17N5OS/c1-12-3-2-4-15(9-12)25-20(26)24-14-7-5-13(6-8-14)16-10-27-19-17(16)18(21)22-11-23-19/h2-11H,1H3,(H2,21,22,23)(H2,24,25,26) DZSUJUOJJJCWGG-UHFFFAOYSA-N 8826 3-(4-{4-aminothieno[2,3-d]pyrimidin-5-yl}phenyl)-1-(3-methylphenyl)urea::Biochemistry 469551 Compound 3::CHEMBL196363::KDR Kinase Inhibitor, 1::N-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-N -(3-methylphenyl)urea::Thienopyrimidine deriv. 76 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6539985 11109564 CHEMBL196363 ZINC13673611 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45441 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45442 NC(=O)c1c(NC(=O)NCCCCN2CCCC2)snc1OCc1c(F)cc(Br)cc1F InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30) HXHAJRMTJXHJJZ-UHFFFAOYSA-N 25115 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(pyrrolidin-1-yl)butyl]carbamoyl}amino)-1,2-thiazole-4-carboxamide::CHEMBL253969::CP 547632::CP547632, 24::US9446026, 1 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25115&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BFF 3L8S 9811611 56374257 CHEMBL253969 ZINC03834191 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45443 Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C InChI=1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19) ZVPDNRVYHLRXLX-UHFFFAOYSA-N 25116 1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL306380::PP1::US10688093, Compound PP1 (Pfizer)::US10807986, Comparative compound 1::US11046696, Compound 1 of Comparative Examples::US11701353, PP1 (Pfizer)::cid_1400 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25116&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search PP1 5FM2,5FM3,4FEV,1QCF,2IVV 1400 56374258 CHEMBL306380 DB01809 ZINC02047275 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45444 C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12 InChI=1S/C16H21N3O2S/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3/t13-/m0/s1 AWDORCFLUJZUQS-ZDUSSCGKSA-N 14028 (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE::4-methyl-5-{[(2S)-2-methyl-1,4-diazepane-1-]sulfonyl}isoquinoline::H-1152::H-1152P Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14028&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search H52 2GNH,2GNL,5M6V,4F1T,3D9V,1Q8U 448043 46514393 DB07876 ZINC00022706 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45445 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45446 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45447 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45448 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45449 N[C@H](COc1cncc(c1)-c1cc2ccncc2s1)Cc1c[nH]c2ccccc12 InChI=1S/C23H20N4OS/c24-18(7-16-11-27-21-4-2-1-3-20(16)21)14-28-19-8-17(10-26-12-19)22-9-15-5-6-25-13-23(15)29-22/h1-6,8-13,18,27H,7,14,24H2/t18-/m0/s1 GWJHMRBQEUHFOC-SFHVURJKSA-N 16919 3-[(2S)-2-amino-3-[(5-{thieno[2,3-c]pyridin-2-yl}pyridin-3-yl)oxy]propyl]-1H-indole::Biochemistry 469551 Compound 12::CHEMBL516429::thieno[2,3-c]pyridine, 9a Serine/threonine-protein kinase PLK1 Homo sapiens 10000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10216158 46517151 CHEMBL516429 ZINC14962351 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45450 N[C@H](COc1cncc(c1)-c1ccc2NC(=O)\C(=C\c3ccco3)c2c1)Cc1c[nH]c2ccccc12 InChI=1S/C29H24N4O3/c30-21(10-20-15-32-27-6-2-1-5-24(20)27)17-36-23-11-19(14-31-16-23)18-7-8-28-25(12-18)26(29(34)33-28)13-22-4-3-9-35-22/h1-9,11-16,21,32H,10,17,30H2,(H,33,34)/b26-13+/t21-/m0/s1 BSFNGHCTZDCQBF-ZUICHYAESA-N 25119 (3E)-5-(5-{[(2S)-2-amino-3-(1H-indol-3-yl)propyl]oxy}pyridin-3-yl)-3-(furan-2-ylmethylidene)-1,3-dihydro-2H-indol-2-one::(3E)-5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}-3-(furan-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one::dihydroindol-2-one, 13 Serine/threonine-protein kinase PLK1 Homo sapiens 31000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25119&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25023776 56374261 ZINC06718485 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45451 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45452 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase PLK1 Homo sapiens >20000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45453 Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12 InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29) VWVYILCFSYNJHF-UHFFFAOYSA-N 3033 3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-3-yl}propanenitrile::CHEMBL302449::Go 6976::Indolocarbazole deriv. Serine/threonine-protein kinase PLK1 Homo sapiens >8000 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=3033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=3033&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 85X 5XGN,5XGM 3501 8032780 51913 CHEMBL302449 5973 ZINC01554668 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45454 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 790 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45455 O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 CZQHHVNHHHRRDU-UHFFFAOYSA-N 12915 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one::2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one::CHEMBL98350::LY294002::US10308662, Compound LY294002::US9505780, LY294002 Serine/threonine-protein kinase PLK1 Homo sapiens 6100 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search LY2 1E7V,1YI3,4AZT,4CFK,6G0D 3973 46509407 65329 CHEMBL98350 DB02656 6004 C15195 ZINC37858693 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45456 COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 QDLHCMPXEPAAMD-QAIWCSMKSA-N 15234 (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate::CHEMBL428496::NSC221019::Wortmannin::Wortmannin, Wm::cid_312145 Serine/threonine-protein kinase PLK1 Homo sapiens 1500 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15234&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search KWT 3HHM,1E7U,7OTV,3D5X 312145 46515542 52289 CHEMBL428496 DB08059 6060 C15181 ZINC01619592 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45457 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29) JSKUWFIZUALZLX-UHFFFAOYSA-N 25120 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::BMCL191018 Compound 2::thiophene deriv., 20 Serine/threonine-protein kinase PLK1 Homo sapiens 4.8 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25120&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9826308 56374262 ZINC03939511 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 45458 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens <1 7.5 22.00 C Curated from the literature by BindingDB 10.1021/bi7008745 10.7270/Q28G8J11 17655330 aid1798514 Johnson, EF; Stewart, KD; Woods, KW; Giranda, VL; Luo, Y Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50258 COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26) YYZTVTZCYVZGRB-UHFFFAOYSA-N 27444 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-methanesulfonylphenyl)methoxy]thiophene-2-carboxamide::BMCL191018 Compound 39::benzimidazole-thiophene carboxamide, 2 Serine/threonine-protein kinase PLK1 Homo sapiens 126 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.018 10.7270/Q2VQ311M 16997559 aid1798807 Bamborough, P; Christopher, JA; Cutler, GJ; Dickson, MC; Mellor, GW; Morey, JV; Patel, CB; Shewchuk, LM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27444&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25190912 57299153 ZINC19795632 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50259 COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C#N)c2cc1OC InChI=1S/C22H19N3O5S2/c1-28-18-8-16-17(9-19(18)29-2)25(13-24-16)22-10-20(21(11-23)31-22)30-12-14-4-6-15(7-5-14)32(3,26)27/h4-10,13H,12H2,1-3H3 PZPCKANQRXHUSX-UHFFFAOYSA-N 27445 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-methanesulfonylphenyl)methoxy]thiophene-2-carbonitrile::benzimidazole-thiophene carbonitrile, 3 Serine/threonine-protein kinase PLK1 Homo sapiens 631 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.018 10.7270/Q2VQ311M 16997559 aid1798807 Bamborough, P; Christopher, JA; Cutler, GJ; Dickson, MC; Mellor, GW; Morey, JV; Patel, CB; Shewchuk, LM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27445&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25190913 57299154 ZINC40576752 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50260 COc1cc2ncn(-c3cc(OCC4CCCO4)c(s3)C(N)=O)c2cc1OC InChI=1S/C19H21N3O5S/c1-24-14-6-12-13(7-15(14)25-2)22(10-21-12)17-8-16(18(28-17)19(20)23)27-9-11-4-3-5-26-11/h6-8,10-11H,3-5,9H2,1-2H3,(H2,20,23) RNXPIGAWEIQILT-UHFFFAOYSA-N 27446 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxolan-2-ylmethoxy)thiophene-2-carboxamide::benzimidazole-thiophene carboxamide, 4 Serine/threonine-protein kinase PLK1 Homo sapiens 251 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.018 10.7270/Q2VQ311M 16997559 aid1798807 Bamborough, P; Christopher, JA; Cutler, GJ; Dickson, MC; Mellor, GW; Morey, JV; Patel, CB; Shewchuk, LM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27446&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25190914 57299155 ZINC40576689 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50261 COc1cc2ncn(-c3cc(OCC4CCCO4)c(s3)C#N)c2cc1OC InChI=1S/C19H19N3O4S/c1-23-15-6-13-14(7-16(15)24-2)22(11-21-13)19-8-17(18(9-20)27-19)26-10-12-4-3-5-25-12/h6-8,11-12H,3-5,10H2,1-2H3 SNDWQKOLRNGWRH-UHFFFAOYSA-N 27447 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxolan-2-ylmethoxy)thiophene-2-carbonitrile::benzimidazole-thiophene carbonitrile, 5 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.018 10.7270/Q2VQ311M 16997559 aid1798807 Bamborough, P; Christopher, JA; Cutler, GJ; Dickson, MC; Mellor, GW; Morey, JV; Patel, CB; Shewchuk, LM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27447&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11625181 57299156 ZINC35950838 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50262 COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C#N)c2cc1OC InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3 LDTAHRLHGHFHKP-UHFFFAOYSA-N 27452 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-methanesulfonylphenyl)methoxy]thiophene-2-carbonitrile::benzimidazole-thiophene carbonitrile, 12e Serine/threonine-protein kinase PLK1 Homo sapiens 794 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.018 10.7270/Q2VQ311M 16997559 aid1798807 Bamborough, P; Christopher, JA; Cutler, GJ; Dickson, MC; Mellor, GW; Morey, JV; Patel, CB; Shewchuk, LM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27452&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11626927 57299161 ZINC19795634 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50264 Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1 InChI=1S/C20H17N3O2S/c1-13-6-8-14(9-7-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24) LGVVNIMZHUYDAQ-UHFFFAOYSA-N 27443 5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)methoxy]thiophene-2-carboxamide::BMCL191018 Compound 9::benzimidazole-thiophene carboxamide, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 126 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2006.09.018 10.7270/Q2VQ311M 16997559 aid1798807 Bamborough, P; Christopher, JA; Cutler, GJ; Dickson, MC; Mellor, GW; Morey, JV; Patel, CB; Shewchuk, LM GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27443&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25190911 57299152 ZINC40380218 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51341 NC(=O)c1sc(cc1OCc1ccccc1)-n1cnc2ccccc12 InChI=1S/C19H15N3O2S/c20-19(23)18-16(24-11-13-6-2-1-3-7-13)10-17(25-18)22-12-21-14-8-4-5-9-15(14)22/h1-10,12H,11H2,(H2,20,23) UKMFNYMKFVWNPN-UHFFFAOYSA-N 28156 5-(1H-1,3-benzodiazol-1-yl)-3-(benzyloxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 61 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28156&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263074 58097345 ZINC40935528 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51342 Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12 InChI=1S/C20H17N3O2S/c1-13-6-2-3-7-14(13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-8-4-5-9-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24) WDCZFVDKEGZRSJ-UHFFFAOYSA-N 28157 5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methylphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 7 Serine/threonine-protein kinase PLK1 Homo sapiens 12 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28157&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263075 58097346 ZINC40935836 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51343 Cc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1 InChI=1S/C20H17N3O2S/c1-13-5-4-6-14(9-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24) UGQFNSQKIGSKJD-UHFFFAOYSA-N 28158 5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methylphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 8 Serine/threonine-protein kinase PLK1 Homo sapiens 12 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28158&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263076 58097347 ZINC40378960 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51344 Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1 InChI=1S/C20H17N3O2S/c1-13-6-8-14(9-7-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24) LGVVNIMZHUYDAQ-UHFFFAOYSA-N 27443 5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)methoxy]thiophene-2-carboxamide::BMCL191018 Compound 9::benzimidazole-thiophene carboxamide, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 70 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27443&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25190911 57299152 ZINC40380218 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51345 COc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12 InChI=1S/C20H17N3O3S/c1-25-16-9-5-2-6-13(16)11-26-17-10-18(27-19(17)20(21)24)23-12-22-14-7-3-4-8-15(14)23/h2-10,12H,11H2,1H3,(H2,21,24) DHVZYFGOAOVOBJ-UHFFFAOYSA-N 28159 5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methoxyphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 10 Serine/threonine-protein kinase PLK1 Homo sapiens 12 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28159&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263077 58097348 ZINC40404309 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51346 COc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1 InChI=1S/C20H17N3O3S/c1-25-14-6-4-5-13(9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24) DSRCAFSFCNIHTE-UHFFFAOYSA-N 28160 5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methoxyphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 11 Serine/threonine-protein kinase PLK1 Homo sapiens 28 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28160&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263078 58097349 ZINC40917958 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51347 COc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1 InChI=1S/C20H17N3O3S/c1-25-14-8-6-13(7-9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24) PTFWTMLTKFRZKM-UHFFFAOYSA-N 28161 5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 12 Serine/threonine-protein kinase PLK1 Homo sapiens 35 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28161&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263079 58097350 ZINC40913349 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51348 NC(=O)c1sc(cc1OCc1ccccc1Cl)-n1cnc2ccccc12 InChI=1S/C19H14ClN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24) RGXPTTVHZKAPKA-UHFFFAOYSA-N 28162 5-(1H-1,3-benzodiazol-1-yl)-3-[(2-chlorophenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 13 Serine/threonine-protein kinase PLK1 Homo sapiens 12 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28162&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263080 58097351 ZINC40913931 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51349 NC(=O)c1sc(cc1OCc1cccc(Cl)c1)-n1cnc2ccccc12 InChI=1S/C19H14ClN3O2S/c20-13-5-3-4-12(8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-6-1-2-7-15(14)23/h1-9,11H,10H2,(H2,21,24) CGYQIDZVXVYVAI-UHFFFAOYSA-N 28163 5-(1H-1,3-benzodiazol-1-yl)-3-[(3-chlorophenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 14 Serine/threonine-protein kinase PLK1 Homo sapiens 22 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28163&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263081 58097352 ZINC40981100 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51350 NC(=O)c1sc(cc1OCc1ccc(Cl)cc1)-n1cnc2ccccc12 InChI=1S/C19H14ClN3O2S/c20-13-7-5-12(6-8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-3-1-2-4-15(14)23/h1-9,11H,10H2,(H2,21,24) APHCQWVQIPOIEG-UHFFFAOYSA-N 28164 5-(1H-1,3-benzodiazol-1-yl)-3-[(4-chlorophenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 15 Serine/threonine-protein kinase PLK1 Homo sapiens 100 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28164&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263082 58097353 ZINC40410920 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51351 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2ccccc12 InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-6-2-1-5-12(13)10-28-16-9-17(29-18(16)19(24)27)26-11-25-14-7-3-4-8-15(14)26/h1-9,11H,10H2,(H2,24,27) ITAJXWHXKVYGCF-UHFFFAOYSA-N 28165 5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 16 Serine/threonine-protein kinase PLK1 Homo sapiens 15 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28165&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10409707 58097354 ZINC38798231 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51352 NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2ccccc12 InChI=1S/C19H14BrN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24) BWZJWBWWGBNPLH-UHFFFAOYSA-N 28166 5-(1H-1,3-benzodiazol-1-yl)-3-[(2-bromophenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 17 Serine/threonine-protein kinase PLK1 Homo sapiens 11 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28166&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263083 58097355 ZINC40420729 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51353 NC(=O)c1sc(cc1OCc1ccccc1F)-n1cnc2ccccc12 InChI=1S/C19H14FN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24) QBUKWINFURUTNN-UHFFFAOYSA-N 28167 5-(1H-1,3-benzodiazol-1-yl)-3-[(2-fluorophenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 18 Serine/threonine-protein kinase PLK1 Homo sapiens 14 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28167&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263084 58097356 ZINC40380488 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51354 Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2cc(Cl)ccc12 InChI=1S/C20H16ClN3O2S/c1-12-4-2-3-5-13(12)10-26-17-9-18(27-19(17)20(22)25)24-11-23-15-8-14(21)6-7-16(15)24/h2-9,11H,10H2,1H3,(H2,22,25) RGYLSTMWQZFYAE-UHFFFAOYSA-N 28168 5-(5-chloro-1H-1,3-benzodiazol-1-yl)-3-[(2-methylphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 19 Serine/threonine-protein kinase PLK1 Homo sapiens 21 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28168&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263085 58097357 ZINC40933507 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51355 Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccc(Cl)cc12 InChI=1S/C20H16ClN3O2S/c1-12-4-2-3-5-13(12)10-26-17-9-18(27-19(17)20(22)25)24-11-23-15-7-6-14(21)8-16(15)24/h2-9,11H,10H2,1H3,(H2,22,25) ILPWOGVVNMOKPO-UHFFFAOYSA-N 28169 5-(6-chloro-1H-1,3-benzodiazol-1-yl)-3-[(2-methylphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 20 Serine/threonine-protein kinase PLK1 Homo sapiens 4 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28169&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263086 58097358 ZINC40414162 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51356 NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2cc(ccc12)C(F)(F)F InChI=1S/C20H13BrF3N3O2S/c21-13-4-2-1-3-11(13)9-29-16-8-17(30-18(16)19(25)28)27-10-26-14-7-12(20(22,23)24)5-6-15(14)27/h1-8,10H,9H2,(H2,25,28) BXJGJFDHPWFFFF-UHFFFAOYSA-N 28170 3-[(2-bromophenyl)methoxy]-5-[5-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]thiophene-2-carboxamide::benzimidazole thiophene analogue, 21 Serine/threonine-protein kinase PLK1 Homo sapiens 300 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28170&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263087 58097359 ZINC40420764 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357 NC(=O)c1sc(cc1OCc1ccccc1Br)-n1cnc2ccc(cc12)C(F)(F)F InChI=1S/C20H13BrF3N3O2S/c21-13-4-2-1-3-11(13)9-29-16-8-17(30-18(16)19(25)28)27-10-26-14-6-5-12(7-15(14)27)20(22,23)24/h1-8,10H,9H2,(H2,25,28) LOKKVFGDJAVMLU-UHFFFAOYSA-N 28171 3-[(2-bromophenyl)methoxy]-5-[6-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]thiophene-2-carboxamide::benzimidazole thiophene analogue, 22 Serine/threonine-protein kinase PLK1 Homo sapiens 9 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28171&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263088 58097360 ZINC40934898 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51358 CS(=O)(=O)c1ccc2n(cnc2c1)-c1cc(OCc2ccccc2C(F)(F)F)c(s1)C(N)=O InChI=1S/C21H16F3N3O4S2/c1-33(29,30)13-6-7-16-15(8-13)26-11-27(16)18-9-17(19(32-18)20(25)28)31-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28) RTQWRFHQGAJDII-UHFFFAOYSA-N 28172 5-(5-methanesulfonyl-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 23 Serine/threonine-protein kinase PLK1 Homo sapiens 250 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28172&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263089 58097361 ZINC40412980 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51359 CS(=O)(=O)c1ccc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1 InChI=1S/C21H16F3N3O4S2/c1-33(29,30)13-6-7-15-16(8-13)27(11-26-15)18-9-17(19(32-18)20(25)28)31-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28) PKLMXGCVMJKTHE-UHFFFAOYSA-N 28173 5-(6-methanesulfonyl-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 24 Serine/threonine-protein kinase PLK1 Homo sapiens 12 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28173&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10074495 58097362 ZINC34177081 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51360 COc1ccc2n(cnc2c1)-c1cc(OCc2ccccc2C(F)(F)F)c(s1)C(N)=O InChI=1S/C21H16F3N3O3S/c1-29-13-6-7-16-15(8-13)26-11-27(16)18-9-17(19(31-18)20(25)28)30-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28) VEUXEULZTVVJRP-UHFFFAOYSA-N 28174 5-(5-methoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 25 Serine/threonine-protein kinase PLK1 Homo sapiens 8 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28174&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263090 58097363 ZINC40402975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51361 COc1ccc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1 InChI=1S/C21H16F3N3O3S/c1-29-13-6-7-15-16(8-13)27(11-26-15)18-9-17(19(31-18)20(25)28)30-10-12-4-2-3-5-14(12)21(22,23)24/h2-9,11H,10H2,1H3,(H2,25,28) CZFBBQGDVUHJKQ-UHFFFAOYSA-N 28175 5-(6-methoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 26 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28175&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10253033 58097364 ZINC38429265 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51362 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29) JSKUWFIZUALZLX-UHFFFAOYSA-N 25120 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::BMCL191018 Compound 2::thiophene deriv., 20 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25120&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9826308 56374262 ZINC03939511 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363 COc1cc2ncn(-c3cc(OCc4ccccc4)c(s3)C(N)=O)c2cc1OC InChI=1S/C21H19N3O4S/c1-26-16-8-14-15(9-17(16)27-2)24(12-23-14)19-10-18(20(29-19)21(22)25)28-11-13-6-4-3-5-7-13/h3-10,12H,11H2,1-2H3,(H2,22,25) BVFNLUKEPFBRGA-UHFFFAOYSA-N 28176 3-(benzyloxy)-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 27 Serine/threonine-protein kinase PLK1 Homo sapiens 12 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28176&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263091 58097365 ZINC40917157 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364 COc1cc2ncn(-c3cc(OCc4ccccc4Br)c(s3)C(N)=O)c2cc1OC InChI=1S/C21H18BrN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26) TUIAPCRJMAZDMG-UHFFFAOYSA-N 28177 3-[(2-bromophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 28 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28177&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10254917 58097366 ZINC03939513 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51365 COc1cc2ncn(-c3cc(OCc4ccccc4Cl)c(s3)C(N)=O)c2cc1OC InChI=1S/C21H18ClN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26) WRWFZZDBIJLBIJ-UHFFFAOYSA-N 28178 3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::BMCL191694 Compound 2::benzimidazole thiophene analogue, 29 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28178&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263092 58097367 ZINC40407002 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51366 COc1cc2ncn(-c3cc(OCc4ccccc4C#N)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H18N4O4S/c1-28-17-7-15-16(8-18(17)29-2)26(12-25-15)20-9-19(21(31-20)22(24)27)30-11-14-6-4-3-5-13(14)10-23/h3-9,12H,11H2,1-2H3,(H2,24,27) YEYUQGORXHKMDB-UHFFFAOYSA-N 28179 3-[(2-cyanophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 30 Serine/threonine-protein kinase PLK1 Homo sapiens 6 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28179&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263093 58097368 ZINC40913877 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51368 COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H21N3O6S2/c1-29-16-8-14-15(9-17(16)30-2)25(12-24-14)20-10-18(21(32-20)22(23)26)31-11-13-6-4-5-7-19(13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26) RKJSOZZVROHVEG-UHFFFAOYSA-N 28180 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-methanesulfonylphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 31 Serine/threonine-protein kinase PLK1 Homo sapiens 31 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28180&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24281531 58097369 ZINC11906992 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51369 COc1cc2ncn(-c3cc(OCc4ccccc4C(C)=O)c(s3)C(N)=O)c2cc1OC InChI=1S/C23H21N3O5S/c1-13(27)15-7-5-4-6-14(15)11-31-20-10-21(32-22(20)23(24)28)26-12-25-16-8-18(29-2)19(30-3)9-17(16)26/h4-10,12H,11H2,1-3H3,(H2,24,28) CMFKBVPIQXKAAT-UHFFFAOYSA-N 28181 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-acetylphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 32 Serine/threonine-protein kinase PLK1 Homo sapiens 17 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28181&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263094 58097370 ZINC40898094 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51370 COc1cc2ncn(-c3cc(OCc4ccccc4OC(F)(F)F)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H18F3N3O5S/c1-30-16-7-13-14(8-17(16)31-2)28(11-27-13)19-9-18(20(34-19)21(26)29)32-10-12-5-3-4-6-15(12)33-22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29) HHJNULHGUASGCC-UHFFFAOYSA-N 28182 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethoxy)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 33 Serine/threonine-protein kinase PLK1 Homo sapiens 5 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28182&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9983158 58097371 ZINC40407319 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51371 COc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2cc(OC)c(OC)cc12 InChI=1S/C22H21N3O5S/c1-27-16-7-5-4-6-13(16)11-30-19-10-20(31-21(19)22(23)26)25-12-24-14-8-17(28-2)18(29-3)9-15(14)25/h4-10,12H,11H2,1-3H3,(H2,23,26) YZFNBSBVUBBHGO-UHFFFAOYSA-N 28183 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-methoxyphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 34 Serine/threonine-protein kinase PLK1 Homo sapiens 8 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28183&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263095 58097372 ZINC40406884 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51372 COc1cc2ncn(-c3cc(OCc4cccc(c4)N(C)C)c(s3)C(N)=O)c2cc1OC InChI=1S/C23H24N4O4S/c1-26(2)15-7-5-6-14(8-15)12-31-20-11-21(32-22(20)23(24)28)27-13-25-16-9-18(29-3)19(30-4)10-17(16)27/h5-11,13H,12H2,1-4H3,(H2,24,28) OKLYPNBPHHIICB-UHFFFAOYSA-N 28184 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[3-(dimethylamino)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 35 Serine/threonine-protein kinase PLK1 Homo sapiens 31 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28184&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263096 58097373 ZINC40914646 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51373 COc1cc2ncn(-c3cc(OCc4cccc(N)c4)c(s3)C(N)=O)c2cc1OC InChI=1S/C21H20N4O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-4-3-5-13(22)6-12/h3-9,11H,10,22H2,1-2H3,(H2,23,26) ZLNYTTROVPFOPQ-UHFFFAOYSA-N 28185 3-[(3-aminophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 36 Serine/threonine-protein kinase PLK1 Homo sapiens 21 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28185&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11743086 58097374 ZINC36402318 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51374 COc1cc2ncn(-c3cc(OCc4cccc(c4)C#N)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H18N4O4S/c1-28-17-7-15-16(8-18(17)29-2)26(12-25-15)20-9-19(21(31-20)22(24)27)30-11-14-5-3-4-13(6-14)10-23/h3-9,12H,11H2,1-2H3,(H2,24,27) QEGCURQNODRWMV-UHFFFAOYSA-N 28186 3-[(3-cyanophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 37 Serine/threonine-protein kinase PLK1 Homo sapiens 99 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28186&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263097 58097375 ZINC40915598 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51375 COc1ccc(COc2cc(sc2C(N)=O)-n2cnc3cc(OC)c(OC)cc23)cc1 InChI=1S/C22H21N3O5S/c1-27-14-6-4-13(5-7-14)11-30-19-10-20(31-21(19)22(23)26)25-12-24-15-8-17(28-2)18(29-3)9-16(15)25/h4-10,12H,11H2,1-3H3,(H2,23,26) SBNGSSJCJRSCAZ-UHFFFAOYSA-N 28187 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-methoxyphenyl)methoxy]thiophene-2-carboxamide::benzimidazole thiophene analogue, 38 Serine/threonine-protein kinase PLK1 Homo sapiens 13 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28187&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263098 58097376 ZINC40408099 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51376 COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26) YYZTVTZCYVZGRB-UHFFFAOYSA-N 27444 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-methanesulfonylphenyl)methoxy]thiophene-2-carboxamide::BMCL191018 Compound 39::benzimidazole-thiophene carboxamide, 2 Serine/threonine-protein kinase PLK1 Homo sapiens 75 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27444&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25190912 57299153 ZINC19795632 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51377 COc1cc2ncn(-c3cc(OCCc4ccccc4)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H21N3O4S/c1-27-17-10-15-16(11-18(17)28-2)25(13-24-15)20-12-19(21(30-20)22(23)26)29-9-8-14-6-4-3-5-7-14/h3-7,10-13H,8-9H2,1-2H3,(H2,23,26) WJXHPWZUPIMHJP-UHFFFAOYSA-N 28188 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(2-phenylethoxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 40 Serine/threonine-protein kinase PLK1 Homo sapiens 130 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28188&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263099 58097377 ZINC40898996 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51378 COc1cc2ncn(-c3cc(OCCCc4ccccc4)c(s3)C(N)=O)c2cc1OC InChI=1S/C23H23N3O4S/c1-28-18-11-16-17(12-19(18)29-2)26(14-25-16)21-13-20(22(31-21)23(24)27)30-10-6-9-15-7-4-3-5-8-15/h3-5,7-8,11-14H,6,9-10H2,1-2H3,(H2,24,27) ZRDJTQFOUXSKBC-UHFFFAOYSA-N 28189 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(3-phenylpropoxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 41 Serine/threonine-protein kinase PLK1 Homo sapiens 61 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28189&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263100 58097378 ZINC40406434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51379 COc1cc2ncn(-c3cc(OCC4CCCC4)c(s3)C(N)=O)c2cc1OC InChI=1S/C20H23N3O4S/c1-25-15-7-13-14(8-16(15)26-2)23(11-22-13)18-9-17(19(28-18)20(21)24)27-10-12-5-3-4-6-12/h7-9,11-12H,3-6,10H2,1-2H3,(H2,21,24) VRMPQRSIIRANNY-UHFFFAOYSA-N 28190 3-(cyclopentylmethoxy)-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 42 Serine/threonine-protein kinase PLK1 Homo sapiens 34 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28190&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263101 58097379 ZINC40898999 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51380 COc1cc2ncn(-c3cc(OCC4CCCCC4)c(s3)C(N)=O)c2cc1OC InChI=1S/C21H25N3O4S/c1-26-16-8-14-15(9-17(16)27-2)24(12-23-14)19-10-18(20(29-19)21(22)25)28-11-13-6-4-3-5-7-13/h8-10,12-13H,3-7,11H2,1-2H3,(H2,22,25) WLALQQYUBWGRLL-UHFFFAOYSA-N 28191 3-(cyclohexylmethoxy)-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 43 Serine/threonine-protein kinase PLK1 Homo sapiens 17 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28191&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263102 58097380 ZINC40935407 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51381 COc1cc2ncn(-c3cc(OCc4cccs4)c(s3)C(N)=O)c2cc1OC InChI=1S/C19H17N3O4S2/c1-24-14-6-12-13(7-15(14)25-2)22(10-21-12)17-8-16(18(28-17)19(20)23)26-9-11-4-3-5-27-11/h3-8,10H,9H2,1-2H3,(H2,20,23) UKFXNDDYHAHTEM-UHFFFAOYSA-N 28192 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(thiophen-2-ylmethoxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 44 Serine/threonine-protein kinase PLK1 Homo sapiens 11 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28192&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263103 58097381 ZINC40410620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51382 COc1cc2ncn(-c3cc(OCc4ccsc4)c(s3)C(N)=O)c2cc1OC InChI=1S/C19H17N3O4S2/c1-24-14-5-12-13(6-15(14)25-2)22(10-21-12)17-7-16(18(28-17)19(20)23)26-8-11-3-4-27-9-11/h3-7,9-10H,8H2,1-2H3,(H2,20,23) FSKPWMXAGUNAEU-UHFFFAOYSA-N 28193 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(thiophen-3-ylmethoxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 45 Serine/threonine-protein kinase PLK1 Homo sapiens 17 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28193&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263104 58097382 ZINC40935703 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51383 COc1cc2ncn(-c3cc(OCc4sccc4Cl)c(s3)C(N)=O)c2cc1OC InChI=1S/C19H16ClN3O4S2/c1-25-13-5-11-12(6-14(13)26-2)23(9-22-11)17-7-15(18(29-17)19(21)24)27-8-16-10(20)3-4-28-16/h3-7,9H,8H2,1-2H3,(H2,21,24) ZTWJDVNPCLUQPU-UHFFFAOYSA-N 28194 3-[(3-chlorothiophen-2-yl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 46 Serine/threonine-protein kinase PLK1 Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28194&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263105 58097383 ZINC40935726 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51384 COc1cc2ncn(-c3cc(OCc4ccco4)c(s3)C(N)=O)c2cc1OC InChI=1S/C19H17N3O5S/c1-24-14-6-12-13(7-15(14)25-2)22(10-21-12)17-8-16(18(28-17)19(20)23)27-9-11-4-3-5-26-11/h3-8,10H,9H2,1-2H3,(H2,20,23) SXMLPHKEKWTISC-UHFFFAOYSA-N 28195 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(furan-2-ylmethoxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 47 Serine/threonine-protein kinase PLK1 Homo sapiens 27 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28195&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263106 58097384 ZINC40410812 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51385 COc1cc2ncn(-c3cc(OCc4ccoc4)c(s3)C(N)=O)c2cc1OC InChI=1S/C19H17N3O5S/c1-24-14-5-12-13(6-15(14)25-2)22(10-21-12)17-7-16(18(28-17)19(20)23)27-9-11-3-4-26-8-11/h3-8,10H,9H2,1-2H3,(H2,20,23) MTTPHACIXDOJGQ-UHFFFAOYSA-N 28196 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(furan-3-ylmethoxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 48 Serine/threonine-protein kinase PLK1 Homo sapiens 190 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28196&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263107 58097385 ZINC40919099 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51386 COc1cc2ncn(-c3cc(OCc4ccncc4)c(s3)C(N)=O)c2cc1OC InChI=1S/C20H18N4O4S/c1-26-15-7-13-14(8-16(15)27-2)24(11-23-13)18-9-17(19(29-18)20(21)25)28-10-12-3-5-22-6-4-12/h3-9,11H,10H2,1-2H3,(H2,21,25) XNOBOZRCPWKBSS-UHFFFAOYSA-N 28197 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(pyridin-4-ylmethoxy)thiophene-2-carboxamide::benzimidazole thiophene analogue, 49 Serine/threonine-protein kinase PLK1 Homo sapiens 130 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28197&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263108 58097386 ZINC40917957 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51387 COc1cc2ncn(-c3cc(OCc4ccnc(Br)c4)c(s3)C(N)=O)c2cc1OC InChI=1S/C20H17BrN4O4S/c1-27-14-6-12-13(7-15(14)28-2)25(10-24-12)18-8-16(19(30-18)20(22)26)29-9-11-3-4-23-17(21)5-11/h3-8,10H,9H2,1-2H3,(H2,22,26) MSPPEMIGOSZQOZ-UHFFFAOYSA-N 28198 3-[(2-bromopyridin-4-yl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene analogue, 50 Serine/threonine-protein kinase PLK1 Homo sapiens 14 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28198&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263109 58097387 ZINC40404978 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51388 COC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2cc(OC)c(OC)cc12 InChI=1S/C23H19F3N2O5S/c1-30-17-8-15-16(9-18(17)31-2)28(12-27-15)20-10-19(21(34-20)22(29)32-3)33-11-13-6-4-5-7-14(13)23(24,25)26/h4-10,12H,11H2,1-3H3 QRODFHXJGMZHTM-UHFFFAOYSA-N 28199 benzimidazole thiophene analogue, 51::methyl 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens >1000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28199&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263110 58097388 ZINC40900456 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51389 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(O)=O)c2cc1OC InChI=1S/C22H17F3N2O5S/c1-30-16-7-14-15(8-17(16)31-2)27(11-26-14)19-9-18(20(33-19)21(28)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H,28,29) JAMDNXUAYUHJLJ-UHFFFAOYSA-N 28200 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxylic acid::benzimidazole thiophene analogue, 52 Serine/threonine-protein kinase PLK1 Homo sapiens 2 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28200&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263111 58097389 ZINC40901108 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51390 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C#N)c2cc1OC InChI=1S/C22H16F3N3O3S/c1-29-17-7-15-16(8-18(17)30-2)28(12-27-15)21-9-19(20(10-26)32-21)31-11-13-5-3-4-6-14(13)22(23,24)25/h3-9,12H,11H2,1-2H3 PYVMYBZZIWFCPE-UHFFFAOYSA-N 27448 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carbonitrile::BMCL191018 Compound 53::benzimidazole-thiophene carbonitrile, 12a Serine/threonine-protein kinase PLK1 Homo sapiens 700 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27448&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25190915 57299157 ZINC40753479 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51391 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)-c3nnn[nH]3)c2cc1OC InChI=1S/C22H17F3N6O3S/c1-32-16-7-14-15(8-17(16)33-2)31(11-26-14)19-9-18(20(35-19)21-27-29-30-28-21)34-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H,27,28,29,30) UFVFOXCVVIBWKI-UHFFFAOYSA-N 28201 5,6-dimethoxy-1-[5-(1H-1,2,3,4-tetrazol-5-yl)-4-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl]-1H-1,3-benzodiazole::benzimidazole thiophene analogue, 54 Serine/threonine-protein kinase PLK1 Homo sapiens 73 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28201&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263112 58097390 ZINC40936431 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51392 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=S)c2cc1OC InChI=1S/C22H18F3N3O3S2/c1-29-16-7-14-15(8-17(16)30-2)28(11-27-14)19-9-18(20(33-19)21(26)32)31-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,32) ILMBJKKVPWRVCZ-UHFFFAOYSA-N 28202 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carbothioamide::benzimidazole thiophene analogue, 55 Serine/threonine-protein kinase PLK1 Homo sapiens 6 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28202&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263113 58097391 ZINC40410282 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51393 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(C)=O)c2cc1OC InChI=1S/C23H19F3N2O4S/c1-13(29)22-20(32-11-14-6-4-5-7-15(14)23(24,25)26)10-21(33-22)28-12-27-16-8-18(30-2)19(31-3)9-17(16)28/h4-10,12H,11H2,1-3H3 JFNQBWFEGWHHDQ-UHFFFAOYSA-N 28203 1-[5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophen-2-yl]ethan-1-one::benzimidazole thiophene analogue, 56 Serine/threonine-protein kinase PLK1 Homo sapiens 85 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28203&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263114 58097392 ZINC40394516 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51394 CNC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2cc(OC)c(OC)cc12 InChI=1S/C23H20F3N3O4S/c1-27-22(30)21-19(33-11-13-6-4-5-7-14(13)23(24,25)26)10-20(34-21)29-12-28-15-8-17(31-2)18(32-3)9-16(15)29/h4-10,12H,11H2,1-3H3,(H,27,30) ZBDRKUGDFBDQJP-UHFFFAOYSA-N 28204 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-N-methyl-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 57 Serine/threonine-protein kinase PLK1 Homo sapiens >1000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28204&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263115 58097393 ZINC40934218 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51395 COc1cc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(=O)N(C)C)c2cc1OC InChI=1S/C24H22F3N3O4S/c1-29(2)23(31)22-20(34-12-14-7-5-6-8-15(14)24(25,26)27)11-21(35-22)30-13-28-16-9-18(32-3)19(33-4)10-17(16)30/h5-11,13H,12H2,1-4H3 CKYDKNBLVBVPCS-UHFFFAOYSA-N 28205 5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-N,N-dimethyl-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 58 Serine/threonine-protein kinase PLK1 Homo sapiens >1000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.041 10.7270/Q26T0JZX 19097784 aid1798873 Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28205&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263116 58097394 ZINC40934219 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51396 COc1cc2ncn(-c3cc(OCc4ccccc4Cl)c(s3)C(N)=O)c2cc1OC InChI=1S/C21H18ClN3O4S/c1-27-16-7-14-15(8-17(16)28-2)25(11-24-14)19-9-18(20(30-19)21(23)26)29-10-12-5-3-4-6-13(12)22/h3-9,11H,10H2,1-2H3,(H2,23,26) WRWFZZDBIJLBIJ-UHFFFAOYSA-N 28178 3-[(2-chlorophenyl)methoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::BMCL191694 Compound 2::benzimidazole thiophene analogue, 29 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28178&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263092 58097367 ZINC40407002 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51397 COc1cc2ncn(-c3cc(O[C@H](C)c4ccccc4Cl)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H20ClN3O4S/c1-12(13-6-4-5-7-14(13)23)30-19-10-20(31-21(19)22(24)27)26-11-25-15-8-17(28-2)18(29-3)9-16(15)26/h4-12H,1-3H3,(H2,24,27)/t12-/m1/s1 UHCHLTQBLNUYRT-GFCCVEGCSA-N 28206 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 3 Serine/threonine-protein kinase PLK1 Homo sapiens 0.8 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28206&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BLZ 2I40 11957417 58097395 DB07471 ZINC16052682 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51398 COc1cc2ncn(-c3cc(O[C@@H](C)c4ccccc4Cl)c(s3)C(N)=O)c2cc1OC InChI=1S/C22H20ClN3O4S/c1-12(13-6-4-5-7-14(13)23)30-19-10-20(31-21(19)22(24)27)26-11-25-15-8-17(28-2)18(29-3)9-16(15)26/h4-12H,1-3H3,(H2,24,27)/t12-/m0/s1 UHCHLTQBLNUYRT-LBPRGKRZSA-N 28207 3-[(1S)-1-(2-chlorophenyl)ethoxy]-5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 4 Serine/threonine-protein kinase PLK1 Homo sapiens 30 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28207&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263117 58097396 ZINC16052681 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51399 COc1ccc2ncn(-c3cc(O[C@H](C)c4ccccc4Cl)c(s3)C(N)=O)c2c1 InChI=1S/C21H18ClN3O3S/c1-12(14-5-3-4-6-15(14)22)28-18-10-19(29-20(18)21(23)26)25-11-24-16-8-7-13(27-2)9-17(16)25/h3-12H,1-2H3,(H2,23,26)/t12-/m1/s1 YWNUJKWNTHEOIR-GFCCVEGCSA-N 28208 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(6-methoxy-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 16 Serine/threonine-protein kinase PLK1 Homo sapiens 1 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28208&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263118 58097397 ZINC40429203 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400 COc1ccc2ncn(-c3cc(O[C@H](C)c4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1 InChI=1S/C22H18F3N3O3S/c1-12(14-5-3-4-6-15(14)22(23,24)25)31-18-10-19(32-20(18)21(26)29)28-11-27-16-8-7-13(30-2)9-17(16)28/h3-12H,1-2H3,(H2,26,29)/t12-/m1/s1 CVLJBLIMHPEZJC-GFCCVEGCSA-N 28209 5-(6-methoxy-1H-1,3-benzodiazol-1-yl)-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 17 Serine/threonine-protein kinase PLK1 Homo sapiens 3 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28209&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263119 58097398 ZINC40954961 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51401 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC[C@@H](O)CO)cc12)c1ccccc1Cl InChI=1S/C23H22ClN3O5S/c1-13(16-4-2-3-5-17(16)24)32-20-9-21(33-22(20)23(25)30)27-12-26-18-7-6-15(8-19(18)27)31-11-14(29)10-28/h2-9,12-14,28-29H,10-11H2,1H3,(H2,25,30)/t13-,14+/m1/s1 JVAPIYLPNKDKAQ-KGLIPLIRSA-N 28210 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(2S)-2,3-dihydroxypropoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 18 Serine/threonine-protein kinase PLK1 Homo sapiens 1 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28210&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263120 58097399 C02773 ZINC59259511 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51402 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OCCCN(C)C)cc12)c1ccccc1Cl InChI=1S/C25H27ClN4O3S/c1-16(18-7-4-5-8-19(18)26)33-22-14-23(34-24(22)25(27)31)30-15-28-20-10-9-17(13-21(20)30)32-12-6-11-29(2)3/h4-5,7-10,13-16H,6,11-12H2,1-3H3,(H2,27,31)/t16-/m1/s1 MOSNATYSIYEVTF-MRXNPFEDSA-N 28211 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[3-(dimethylamino)propoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 19 Serine/threonine-protein kinase PLK1 Homo sapiens 4 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28211&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263121 58097400 ZINC59259514 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51403 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC[C@@H](O)CN3CCCC3)cc12)c1ccccc1Cl InChI=1S/C27H29ClN4O4S/c1-17(20-6-2-3-7-21(20)28)36-24-13-25(37-26(24)27(29)34)32-16-30-22-9-8-19(12-23(22)32)35-15-18(33)14-31-10-4-5-11-31/h2-3,6-9,12-13,16-18,33H,4-5,10-11,14-15H2,1H3,(H2,29,34)/t17-,18+/m1/s1 VVQWZQWJWMTPJY-MSOLQXFVSA-N 28212 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(2S)-2-hydroxy-3-(pyrrolidin-1-yl)propoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 20 Serine/threonine-protein kinase PLK1 Homo sapiens 3 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28212&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263122 58097401 ZINC59259516 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51404 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OCC3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C28H29F3N4O3S/c1-17(20-5-3-4-6-21(20)28(29,30)31)38-24-14-25(39-26(24)27(32)36)35-16-33-22-8-7-19(13-23(22)35)37-15-18-9-11-34(2)12-10-18/h3-8,13-14,16-18H,9-12,15H2,1-2H3,(H2,32,36)/t17-/m1/s1 OPJOIUDMJCRLNO-QGZVFWFLSA-N 28213 5-{6-[(1-methylpiperidin-4-yl)methoxy]-1H-1,3-benzodiazol-1-yl}-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 21 Serine/threonine-protein kinase PLK1 Homo sapiens 7 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28213&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263123 58097402 ZINC59259518 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51405 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OCC3CCN(C)CC3)cc12)c1ccccc1Cl InChI=1S/C27H29ClN4O3S/c1-17(20-5-3-4-6-21(20)28)35-24-14-25(36-26(24)27(29)33)32-16-30-22-8-7-19(13-23(22)32)34-15-18-9-11-31(2)12-10-18/h3-8,13-14,16-18H,9-12,15H2,1-2H3,(H2,29,33)/t17-/m1/s1 FCJBLTLQBCHRIE-QGZVFWFLSA-N 28214 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(1-methylpiperidin-4-yl)methoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 22 Serine/threonine-protein kinase PLK1 Homo sapiens 6 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28214&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263124 58097403 ZINC59259519 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51406 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCNCC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C26H25F3N4O3S/c1-15(18-4-2-3-5-19(18)26(27,28)29)35-22-13-23(37-24(22)25(30)34)33-14-32-20-7-6-17(12-21(20)33)36-16-8-10-31-11-9-16/h2-7,12-16,31H,8-11H2,1H3,(H2,30,34)/t15-/m1/s1 SLGRRBVHGIPHNQ-OAHLLOKOSA-N 28215 5-[6-(piperidin-4-yloxy)-1H-1,3-benzodiazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 23 Serine/threonine-protein kinase PLK1 Homo sapiens 3 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28215&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16050921 58097404 ZINC59716238 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51407 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H27F3N4O3S/c1-16(19-5-3-4-6-20(19)27(28,29)30)36-23-14-24(38-25(23)26(31)35)34-15-32-21-8-7-18(13-22(21)34)37-17-9-11-33(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,31,35)/t16-/m1/s1 SWIVJTVGOIXUKC-MRXNPFEDSA-N 28216 5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodiazol-1-yl}-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 24 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28216&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search WGZ 2XNM 16050925 58097405 ZINC59716256 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51408 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12)c1ccccc1Cl InChI=1S/C26H27ClN4O3S/c1-16(19-5-3-4-6-20(19)27)33-23-14-24(35-25(23)26(28)32)31-15-29-21-8-7-18(13-22(21)31)34-17-9-11-30(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,28,32)/t16-/m1/s1 GILNGUYOGYOZMP-MRXNPFEDSA-N 28217 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 25 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28217&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16051023 58097406 ZINC34948948 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51409 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(O[C@H]3CCCN(C)CC3)cc12)c1ccccc1Cl InChI=1S/C27H29ClN4O3S/c1-17(20-7-3-4-8-21(20)28)34-24-15-25(36-26(24)27(29)33)32-16-30-22-10-9-19(14-23(22)32)35-18-6-5-12-31(2)13-11-18/h3-4,7-10,14-18H,5-6,11-13H2,1-2H3,(H2,29,33)/t17-,18+/m1/s1 HLHNFPFYQRRGPP-MSOLQXFVSA-N 28218 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(6-{[(4S)-1-methylazepan-4-yl]oxy}-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 26 Serine/threonine-protein kinase PLK1 Homo sapiens 3 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28218&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263125 58097407 ZINC59259520 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51410 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(O[C@@H]3CCCN(C)CC3)cc12)c1ccccc1Cl InChI=1S/C27H29ClN4O3S/c1-17(20-7-3-4-8-21(20)28)34-24-15-25(36-26(24)27(29)33)32-16-30-22-10-9-19(14-23(22)32)35-18-6-5-12-31(2)13-11-18/h3-4,7-10,14-18H,5-6,11-13H2,1-2H3,(H2,29,33)/t17-,18-/m1/s1 HLHNFPFYQRRGPP-QZTJIDSGSA-N 28219 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(6-{[(4R)-1-methylazepan-4-yl]oxy}-1H-1,3-benzodiazol-1-yl)thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 27 Serine/threonine-protein kinase PLK1 Homo sapiens 4 7.2 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.01.094 10.7270/Q2319T6X 19237286 aid1798875 Emmitte, KA; Adjebang, GM; Andrews, CW; Alberti, JG; Bambal, R; Chamberlain, SD; Davis-Ward, RG; Dickson, HD; Hassler, DF; Hornberger, KR; Jackson, JR; Kuntz, KW; Lansing, TJ; Mook, RA; Nailor, KE; Pobanz, MA; Smith, SC; Sung, CM; Cheung, M GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28219&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25263126 58097408 ZINC59259522 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 67173 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Serine/threonine-protein kinase PLK1 Homo sapiens 5000000 PubChem 10.7270/Q29W0CV4 aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 67174 CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1 HKSZLNNOFSGOKW-HMWZOHBLSA-N 31096 CHEMBL290084::Staurosporine::cid_451705 Serine/threonine-protein kinase PLK1 Homo sapiens 190000 PubChem 10.7270/Q29W0CV4 aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 451705 242052841 CHEMBL290084 346 ZINC05615681 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 64017 Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C15H14N4OS/c1-9-14(21-10(2)17-9)13-7-8-16-15(19-13)18-11-3-5-12(20)6-4-11/h3-8,20H,1-2H3,(H,16,18,19) GDZTURHUKDAJGD-UHFFFAOYSA-N 8053 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24::4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol::4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]phenol, 5::4-{[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]amino}phenol::CHEMBL442957 Serine/threonine-protein kinase PLK1 Homo sapiens 5e+3 7.5 20.00 C Curated from the literature by BindingDB 10.1038/nchembio825 10.7270/Q29C6VS4 17028581 aid1799386 McInnes, C; Mazumdar, A; Mezna, M; Meades, C; Midgley, C; Scaerou, F; Carpenter, L; Mackenzie, M; Taylor, P; Walkinshaw, M; Fischer, PM; Glover, D University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6539291 11108807 CHEMBL442957 ZINC13559869 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 64018 CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C15H15N5OS/c1-9-13(22-15(16-2)18-9)12-7-8-17-14(20-12)19-10-3-5-11(21)6-4-10/h3-8,21H,1-2H3,(H,16,18)(H,17,19,20) OTMLAWRVLMYMDF-UHFFFAOYSA-N 8054 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 25::4-({4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl}amino)phenol::4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2-ylamino]phenol::4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2-ylamino]phenol, 6::CHEMBL47590 Serine/threonine-protein kinase PLK1 Homo sapiens 1.0e+4 7.5 20.00 C Curated from the literature by BindingDB 10.1038/nchembio825 10.7270/Q29C6VS4 17028581 aid1799386 McInnes, C; Mazumdar, A; Mezna, M; Meades, C; Midgley, C; Scaerou, F; Carpenter, L; Mackenzie, M; Taylor, P; Walkinshaw, M; Fischer, PM; Glover, D University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8054&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search CK6 1PXN 447960 11108808 CHEMBL47590 DB04407 ZINC02047390 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 64019 Cc1nc(N)sc1-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C14H13N5OS/c1-8-12(21-13(15)17-8)11-6-7-16-14(19-11)18-9-2-4-10(20)5-3-9/h2-7,20H,1H3,(H2,15,17)(H,16,18,19) MUSBOHKPZFHPFH-UHFFFAOYSA-N 8055 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 26::4-[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-ylamino]phenol::4-[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-ylamino]phenol, 7::4-{[4-(2-amino-4-methyl-1,3-thiazol-5-yl)pyrimidin-2-yl]amino}phenol Serine/threonine-protein kinase PLK1 Homo sapiens 2.5e+4 7.5 20.00 C Curated from the literature by BindingDB 10.1038/nchembio825 10.7270/Q29C6VS4 17028581 aid1799386 McInnes, C; Mazumdar, A; Mezna, M; Meades, C; Midgley, C; Scaerou, F; Carpenter, L; Mackenzie, M; Taylor, P; Walkinshaw, M; Fischer, PM; Glover, D University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8055&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6539292 11108809 ZINC13559870 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78088 COC(=O)c1ccccc1NC1=CC(=NS(=O)(=O)c2cccs2)c2ccccc2C1=O InChI=1S/C22H16N2O5S2/c1-29-22(26)16-9-4-5-10-17(16)23-19-13-18(14-7-2-3-8-15(14)21(19)25)24-31(27,28)20-11-6-12-30-20/h2-13,23H,1H3 SQTXZQUPJDPRBX-UHFFFAOYSA-N 41826 2-[[(4E)-1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]benzoic acid methyl ester::2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonylimino-2-naphthalenyl]amino]benzoic acid methyl ester::MLS000521465::SMR000131873::cid_9550941::methyl 2-[[(4E)-1-oxidanylidene-4-thiophen-2-ylsulfonylimino-naphthalen-2-yl]amino]benzoate::methyl 2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonyliminonaphthalen-2-yl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9550941 252622547 ZINC57608287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78089 O=C(Nc1nc2ccccc2s1)c1cc2COc3ccccc3-c2s1 InChI=1S/C19H12N2O2S2/c22-18(21-19-20-13-6-2-4-8-15(13)25-19)16-9-11-10-23-14-7-3-1-5-12(14)17(11)24-16/h1-9H,10H2,(H,20,21,22) YMEYVTRNCWQUKW-UHFFFAOYSA-N 40208 MLS000522634::N-(1,3-benzothiazol-2-yl)-4H-thieno[3,2-c][1]benzopyran-2-carboxamide::N-(1,3-benzothiazol-2-yl)-4H-thieno[3,2-c]chromene-2-carboxamide::SMR000127901::cid_9550946 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40208&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9550946 252621036 ZINC05050072 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78090 Cc1nc2cccc(C)n2c(=O)c1Cl InChI=1S/C10H9ClN2O/c1-6-4-3-5-8-12-7(2)9(11)10(14)13(6)8/h3-5H,1-2H3 CAMDPFYIYQWBHS-UHFFFAOYSA-N 41827 3-chloranyl-2,6-dimethyl-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethyl-4-pyrido[1,2-a]pyrimidinone::3-chloro-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethyl-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethylpyrido[1,2-a]pyrimidin-4-one::MLS000539503::SMR000125161::cid_3255478 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41827&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3255478 252622548 ZINC03029426 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78091 Cn1cc(SCC(=O)Nc2ccc3OCCOc3c2)c2ccccc12 InChI=1S/C19H18N2O3S/c1-21-11-18(14-4-2-3-5-15(14)21)25-12-19(22)20-13-6-7-16-17(10-13)24-9-8-23-16/h2-7,10-11H,8-9,12H2,1H3,(H,20,22) KEWYZVKHGDWOBD-UHFFFAOYSA-N 41828 MLS000529783::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(1-methylindol-3-yl)sulfanyl-ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(1-methylindol-3-yl)sulfanylacetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(1-methyl-3-indolyl)thio]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(1-methylindol-3-yl)thio]acetamide::SMR000126809::cid_4663634 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41828&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4663634 252622549 ZINC03581738 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78092 Cn1c(nc2ccccc12)-c1cc2ccc(OC(=O)C(C)(C)C)cc2oc1=O InChI=1S/C22H20N2O4/c1-22(2,3)21(26)27-14-10-9-13-11-15(20(25)28-18(13)12-14)19-23-16-7-5-6-8-17(16)24(19)4/h5-12H,1-4H3 SLVVLPLLOLFSNR-UHFFFAOYSA-N 41829 2,2-Dimethyl-propionic acid 3-(1-methyl-1H-benzoimidazol-2-yl)-2-oxo-2H-chromen-7-yl ester::2,2-dimethylpropanoic acid [3-(1-methyl-2-benzimidazolyl)-2-oxo-1-benzopyran-7-yl] ester::2,2-dimethylpropionic acid [2-keto-3-(1-methylbenzimidazol-2-yl)chromen-7-yl] ester::MLS000556974::SMR000148091::[3-(1-methylbenzimidazol-2-yl)-2-oxidanylidene-chromen-7-yl] 2,2-dimethylpropanoate::[3-(1-methylbenzimidazol-2-yl)-2-oxochromen-7-yl] 2,2-dimethylpropanoate::cid_1522831 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41829&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1522831 252622550 ZINC01447934 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78093 CCCc1nc2sc3CCCCc3c2c(=O)n1NC(=O)CCC(O)=O InChI=1S/C17H21N3O4S/c1-2-5-12-18-16-15(10-6-3-4-7-11(10)25-16)17(24)20(12)19-13(21)8-9-14(22)23/h2-9H2,1H3,(H,19,21)(H,22,23) UFZNWSZCQFKQIW-UHFFFAOYSA-N 41830 4-keto-4-[(4-keto-2-propyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-3-yl)amino]butyric acid::4-oxidanylidene-4-[(4-oxidanylidene-2-propyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-3-yl)amino]butanoic acid::4-oxo-4-[(4-oxo-2-propyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-3-yl)amino]butanoic acid::MLS000550849::N-(4-Oxo-2-propyl-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-3-yl)-succinamic acid::SMR000144977::cid_1861941 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41830&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1861941 252622551 ZINC02230233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78094 Cc1oc-2c(c1C(=O)c1ccccc1)C(=O)C(=O)c1ccccc-21 InChI=1S/C20H12O4/c1-11-15(17(21)12-7-3-2-4-8-12)16-19(23)18(22)13-9-5-6-10-14(13)20(16)24-11/h2-10H,1H3 XEMFSKXFWNHKIS-UHFFFAOYSA-N 34691 2-methyl-3-(phenylcarbonyl)benzo[g][1]benzofuran-4,5-dione::3-Benzoyl-2-methyl-naphtho[1,2-b]furan-4,5-dione::3-benzoyl-2-methyl-benzo[g]benzofuran-4,5-quinone::3-benzoyl-2-methylbenzo[g][1]benzofuran-4,5-dione::3-benzoyl-2-methylbenzo[g]benzofuran-4,5-dione::MLS000554105::SMR000146422::cid_3816369 Serine/threonine-protein kinase PLK1 Homo sapiens 43604.00009 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34691&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3816369 252617341 ZINC04785917 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78095 CC(=O)N(N=C1Sc2ccccc2C1=O)c1cccc(C)c1 InChI=1S/C17H14N2O2S/c1-11-6-5-7-13(10-11)19(12(2)20)18-17-16(21)14-8-3-4-9-15(14)22-17/h3-10H,1-2H3 ZTBUBWXLRCXSOT-UHFFFAOYSA-N 41831 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-m-tolyl-hydrazide::MLS000552764::N-(3-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide::N-(3-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide::SMR000146279::cid_759945 Serine/threonine-protein kinase PLK1 Homo sapiens 32933.99811 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41831&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401878 252622552 ZINC12559942 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78096 CC(=O)N(N=C1Sc2ccccc2C1=O)c1ccccc1C InChI=1S/C17H14N2O2S/c1-11-7-3-5-9-14(11)19(12(2)20)18-17-16(21)13-8-4-6-10-15(13)22-17/h3-10H,1-2H3 OBPOWEVMSNKZCM-UHFFFAOYSA-N 41832 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-o-tolyl-hydrazide::MLS000552762::N-(2-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide::N-(2-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::SMR000146277::cid_759936 Serine/threonine-protein kinase PLK1 Homo sapiens 37338.00125 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41832&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401874 252622553 ZINC12561994 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78097 CC(=O)N(N=C1Sc2ccccc2C1=O)c1ccccc1 InChI=1S/C16H12N2O2S/c1-11(19)18(12-7-3-2-4-8-12)17-16-15(20)13-9-5-6-10-14(13)21-16/h2-10H,1H3 KYSFXQOZNRWVLN-UHFFFAOYSA-N 41833 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-phenyl-hydrazide::MLS000552761::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-phenyl-acetamide::N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]-N-phenyl-ethanamide::N-[(3-oxo-1-benzothiophen-2-ylidene)amino]-N-phenylacetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-phenyl-acetamide::SMR000146276::cid_759934 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41833&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401873 252622554 ZINC12561922 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78098 CCOc1ccccc1N1CCN(CC1)C1=C(NS(=O)(=O)c2cccs2)C(=O)c2ccccc2C1=O InChI=1S/C26H25N3O5S2/c1-2-34-21-11-6-5-10-20(21)28-13-15-29(16-14-28)24-23(27-36(32,33)22-12-7-17-35-22)25(30)18-8-3-4-9-19(18)26(24)31/h3-12,17,27H,2,13-16H2,1H3 IWDXUFGXDULHDB-UHFFFAOYSA-N 41834 MLS000551587::N-[1,4-diketo-3-(4-o-phenetylpiperazino)-2-naphthyl]thiophene-2-sulfonamide::N-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]-1,4-dioxo-2-naphthalenyl]-2-thiophenesulfonamide::N-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,4-bis(oxidanylidene)naphthalen-2-yl]thiophene-2-sulfonamide::N-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,4-dioxonaphthalen-2-yl]thiophene-2-sulfonamide::SMR000145512::Thiophene-2-sulfonic acid {3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-1,4-dioxo-1,4-dihydro-naphthalen-2-yl}-amide::cid_1423408 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41834&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1423408 252622555 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78099 CC(C)Nc1nnc(SCC(=O)c2c(N)n(Cc3ccccc3)c(=O)n(C)c2=O)s1 InChI=1S/C19H22N6O3S2/c1-11(2)21-17-22-23-18(30-17)29-10-13(26)14-15(20)25(19(28)24(3)16(14)27)9-12-7-5-4-6-8-12/h4-8,11H,9-10,20H2,1-3H3,(H,21,22) OGOGCOROTDLCTB-UHFFFAOYSA-N 41835 6-amino-1-benzyl-3-methyl-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione::6-amino-1-benzyl-5-[2-[[5-(isopropylamino)-1,3,4-thiadiazol-2-yl]thio]acetyl]-3-methyl-pyrimidine-2,4-quinone::6-amino-3-methyl-5-[1-oxo-2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]thio]ethyl]-1-(phenylmethyl)pyrimidine-2,4-dione::6-azanyl-3-methyl-1-(phenylmethyl)-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanoyl]pyrimidine-2,4-dione::MLS000568091::SMR000154422::cid_2501656 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41835&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2501656 252622556 ZINC03383369 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78100 O=C1C(=O)c2ccccc2-c2ccccc12 InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H YYVYAPXYZVYDHN-UHFFFAOYSA-N 22857 1,2-Dione-Based Compound, 14::9,10-dihydrophenanthrene-9,10-dione::CHEMBL51931::Phenanthrene-9,10 dione::cid_6763 Serine/threonine-protein kinase PLK1 Homo sapiens 10079.99992 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22857&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6763 49846671 37454 CHEMBL51931 C03243 ZINC01529614 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78101 Cc1nn(CCc2n[nH]c(=S)n2-c2cccc(C)c2)c(C)c1[N+]([O-])=O InChI=1S/C16H18N6O2S/c1-10-5-4-6-13(9-10)21-14(17-18-16(21)25)7-8-20-12(3)15(22(23)24)11(2)19-20/h4-6,9H,7-8H2,1-3H3,(H,18,25) VRRDUIBPADYHAW-UHFFFAOYSA-N 41836 3-(2-{4-nitro-3,5-dimethyl-1H-pyrazol-1-yl}ethyl)-4-(3-methylphenyl)-5-sulfanyl-4H-1,2,4-triazole::3-[2-(3,5-dimethyl-4-nitro-1-pyrazolyl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)ethyl]-4-(m-tolyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitropyrazol-1-yl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::MLS000538660::SMR000160121::cid_998946 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41836&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 998946 252622557 ZINC05427265 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78102 Cc1cccc2[nH]c3c(ncnc3c12)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C20H19N5O2/c1-13-4-2-5-14-16(13)17-18(23-14)19(22-12-21-17)24-7-9-25(10-8-24)20(26)15-6-3-11-27-15/h2-6,11-12,23H,7-10H2,1H3 IRQKMWLRGOXGDP-UHFFFAOYSA-N 41837 2-furanyl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)-1-piperazinyl]methanone::2-furyl-[4-(9-methyl-5H-pyrimid[5,4-b]indol-4-yl)piperazino]methanone::Furan-2-yl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)-piperazin-1-yl]-methanone::MLS000558194::SMR000148910::cid_1979644::furan-2-yl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)piperazin-1-yl]methanone Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1979644 252622558 ZINC02368389 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78103 Nc1cc(nn1S(=O)(=O)c1cccc2nsnc12)-c1ccc(Br)cc1 InChI=1S/C15H10BrN5O2S2/c16-10-6-4-9(5-7-10)12-8-14(17)21(18-12)25(22,23)13-3-1-2-11-15(13)20-24-19-11/h1-8H,17H2 WSZWPRMGVHHVON-UHFFFAOYSA-N 41838 2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)-3-pyrazolamine::2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)pyrazol-3-amine::MLS000523036::SMR000128302::[5-(4-bromophenyl)-2-piazthiol-4-ylsulfonyl-pyrazol-3-yl]amine::cid_11957251 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11957251 252622559 ZINC08680561 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78104 NC(=O)C1CCN(CC1)C1=C(Cl)C(=O)c2ccccc2C1=O InChI=1S/C16H15ClN2O3/c17-12-13(19-7-5-9(6-8-19)16(18)22)15(21)11-4-2-1-3-10(11)14(12)20/h1-4,9H,5-8H2,(H2,18,22) JBMKSILOCSVHGX-UHFFFAOYSA-N 41839 1-(3-chloro-1,4-diketo-2-naphthyl)isonipecotamide::1-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-4-piperidinecarboxamide::1-(3-chloro-1,4-dioxo-2-naphthalenyl)-4-piperidinecarboxamide::1-(3-chloro-1,4-dioxonaphthalen-2-yl)piperidine-4-carboxamide::1-[3-chloranyl-1,4-bis(oxidanylidene)naphthalen-2-yl]piperidine-4-carboxamide::MLS000547001::SMR000180199::cid_1481943 Serine/threonine-protein kinase PLK1 Homo sapiens 33256.00052 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41839&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1481943 252622560 ZINC01395148 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78105 Clc1cccc(Cl)c1Cn1cccc(NC(=O)c2c(Cl)cccc2Cl)c1=O InChI=1S/C19H12Cl4N2O2/c20-12-4-1-5-13(21)11(12)10-25-9-3-8-16(19(25)27)24-18(26)17-14(22)6-2-7-15(17)23/h1-9H,10H2,(H,24,26) YODRLVBIQYILMX-UHFFFAOYSA-N 41840 2,6-dichloro-N-[1-(2,6-dichlorobenzyl)-2-keto-3-pyridyl]benzamide::2,6-dichloro-N-[1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydro-3-pyridinyl]benzenecarboxamide::2,6-dichloro-N-[1-[(2,6-dichlorophenyl)methyl]-2-oxo-3-pyridinyl]benzamide::2,6-dichloro-N-[1-[(2,6-dichlorophenyl)methyl]-2-oxopyridin-3-yl]benzamide::MLS000543295::N-[1-[[2,6-bis(chloranyl)phenyl]methyl]-2-oxidanylidene-pyridin-3-yl]-2,6-bis(chloranyl)benzamide::SMR000169264::cid_3679261 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41840&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3679261 252622561 ZINC03041620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78106 Nc1cc2nsnc2cc1Br InChI=1S/C6H4BrN3S/c7-3-1-5-6(2-4(3)8)10-11-9-5/h1-2H,8H2 CDEJXRZSAIZTRF-UHFFFAOYSA-N 40726 (6-bromopiazthiol-5-yl)amine::5-bromanyl-2,1,3-benzothiadiazol-6-amine::5-bromo-2,1,3-benzothiadiazol-6-amine::6-Bromo-benzo[1,2,5]thiadiazol-5-ylamine::MLS000556153::SMR000174162::cid_3096032 Serine/threonine-protein kinase PLK1 Homo sapiens 40805.00031 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40726&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3096032 252621543 ZINC02566853 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78107 Cc1ccc(cc1)C(=O)c1c[nH]c(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C20H25N3O3/c1-15-3-5-16(6-4-15)19(24)17-13-18(22-14-17)20(25)21-7-2-8-23-9-11-26-12-10-23/h3-6,13-14,22H,2,7-12H2,1H3,(H,21,25) XQVAGUMIWDNJTA-UHFFFAOYSA-N 41841 4-(4-methylbenzoyl)-N-(3-morpholin-4-ylpropyl)-1H-pyrrole-2-carboxamide::4-(4-methylbenzoyl)-N-(3-morpholinopropyl)-1H-pyrrole-2-carboxamide::4-(4-methylphenyl)carbonyl-N-(3-morpholin-4-ylpropyl)-1H-pyrrole-2-carboxamide::4-[(4-methylphenyl)-oxomethyl]-N-[3-(4-morpholinyl)propyl]-1H-pyrrole-2-carboxamide::MLS000546923::N-(3-morpholinopropyl)-4-p-toluoyl-1H-pyrrole-2-carboxamide::SMR000180121::cid_3813794 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41841&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3813794 252622562 ZINC20405048 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78108 Cc1ccccc1Oc1ncnc2oc(cc12)-c1ccccc1 InChI=1S/C19H14N2O2/c1-13-7-5-6-10-16(13)22-18-15-11-17(14-8-3-2-4-9-14)23-19(15)21-12-20-18/h2-12H,1H3 ATKPLDDGMIKJMB-UHFFFAOYSA-N 41842 4-(2-methylphenoxy)-6-phenyl-furo[2,3-d]pyrimidine::4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidine::MLS000327159::SMR000179731::cid_3825639 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41842&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3825639 252622563 ZINC06218639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78109 OC1(N2CCCCC2)C(=O)Nc2ccc(cc12)[N+]([O-])=O InChI=1S/C13H15N3O4/c17-12-13(18,15-6-2-1-3-7-15)10-8-9(16(19)20)4-5-11(10)14-12/h4-5,8,18H,1-3,6-7H2,(H,14,17) YNAYNLVTESDOLF-UHFFFAOYSA-N 41843 3-hydroxy-5-nitro-3-(1-piperidinyl)-1,3-dihydro-2H-indol-2-one::3-hydroxy-5-nitro-3-(1-piperidinyl)-1H-indol-2-one::3-hydroxy-5-nitro-3-piperidin-1-yl-1H-indol-2-one::3-hydroxy-5-nitro-3-piperidino-oxindole::5-nitro-3-oxidanyl-3-piperidin-1-yl-1H-indol-2-one::MLS000579145::SMR000186733::cid_2859373 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41843&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2859373 252622564 ZINC04155872 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78110 CCN1C(=O)\C(=C\c2nc3ccccc3c(=O)n2-c2ccccc2)c2ccccc12 InChI=1S/C25H19N3O2/c1-2-27-22-15-9-7-12-18(22)20(24(27)29)16-23-26-21-14-8-6-13-19(21)25(30)28(23)17-10-4-3-5-11-17/h3-16H,2H2,1H3/b20-16+ YTNXBDRGDUEWNI-CAPFRKAQSA-N 41844 2-[(1-ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-phenyl-4(3H)-quinazolinone::2-[(E)-(1-ethyl-2-keto-indolin-3-ylidene)methyl]-3-phenyl-quinazolin-4-one::2-[(E)-(1-ethyl-2-oxidanylidene-indol-3-ylidene)methyl]-3-phenyl-quinazolin-4-one::2-[(E)-(1-ethyl-2-oxo-3-indolylidene)methyl]-3-phenyl-4-quinazolinone::2-[(E)-(1-ethyl-2-oxoindol-3-ylidene)methyl]-3-phenylquinazolin-4-one::MLS000570466::SMR000186892::cid_5336431 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41844&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5336431 252622565 ZINC32609533 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78111 [O-][N+](=O)c1cccc(c1)C(=O)NC(NC(=S)Nc1ccc(Cl)cc1Cl)C(Cl)(Cl)Cl InChI=1S/C16H11Cl5N4O3S/c17-9-4-5-12(11(18)7-9)22-15(29)24-14(16(19,20)21)23-13(26)8-2-1-3-10(6-8)25(27)28/h1-7,14H,(H,23,26)(H2,22,24,29) VAKBSJSQKQOLBN-UHFFFAOYSA-N 41845 3-nitro-N-[2,2,2-trichloro-1-({[(2,4-dichlorophenyl)amino]carbonothioyl}amino)ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[(2,4-dichlorophenyl)carbamothioylamino]ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[(2,4-dichlorophenyl)thiocarbamoylamino]ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[[(2,4-dichloroanilino)-sulfanylidenemethyl]amino]ethyl]benzamide::3-nitro-N-[2,2,2-tris(chloranyl)-1-[(2,4-dichlorophenyl)carbamothioylamino]ethyl]benzamide::MLS000573675::SMR000184524::cid_2830011 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41845&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2830011 252622566 ZINC17320775 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78112 [O-][N+](=O)c1ccc(cc1NCC1CCCO1)N1CCNCC1 InChI=1S/C15H22N4O3/c20-19(21)15-4-3-12(18-7-5-16-6-8-18)10-14(15)17-11-13-2-1-9-22-13/h3-4,10,13,16-17H,1-2,5-9,11H2 NBQUAKXLTFLOAI-UHFFFAOYSA-N 41846 (2-nitro-5-piperazino-phenyl)-(tetrahydrofurfuryl)amine::2-nitro-5-(1-piperazinyl)-N-(tetrahydro-2-furanylmethyl)aniline::2-nitro-N-(2-oxolanylmethyl)-5-(1-piperazinyl)aniline::2-nitro-N-(oxolan-2-ylmethyl)-5-piperazin-1-yl-aniline::2-nitro-N-(oxolan-2-ylmethyl)-5-piperazin-1-ylaniline::MLS000576313::SMR000197953::cid_2933906 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41846&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2933906 252622567 ZINC04140715 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78113 [O-][N+](=O)c1ccc(\C=C(\NC(=O)c2ccccc2)C(=O)NCCc2ccccc2)cc1 InChI=1S/C24H21N3O4/c28-23(20-9-5-2-6-10-20)26-22(17-19-11-13-21(14-12-19)27(30)31)24(29)25-16-15-18-7-3-1-4-8-18/h1-14,17H,15-16H2,(H,25,29)(H,26,28)/b22-17+ MIWCELHLXXHHJL-OQKWZONESA-N 41847 MLS000575866::N-(2-(4-nitrophenyl)-1-{[(2-phenylethyl)amino]carbonyl}vinyl)benzamide::N-[(E)-1-(4-nitrophenyl)-3-oxidanylidene-3-(2-phenylethylamino)prop-1-en-2-yl]benzamide::N-[(E)-1-(4-nitrophenyl)-3-oxo-3-(2-phenylethylamino)prop-1-en-2-yl]benzamide::N-[(E)-2-(4-nitrophenyl)-1-(phenethylcarbamoyl)vinyl]benzamide::SMR000196901::cid_5735412 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41847&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5735412 252622568 ZINC04844883 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80566 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) XSDQTOBWRPYKKA-UHFFFAOYSA-N 16173 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride::3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide::Amiloride::Amipramidin::CHEMBL945 Serine/threonine-protein kinase PLK1 Homo sapiens 6629 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16173&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search AMR 4NTX,1F5L 16231 46516430 2639 CHEMBL945 2421 C06821 ZINC04340269 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80567 Cc1cc(NCCCN)nc(n1)-c1ccccc1O InChI=1S/C14H18N4O/c1-10-9-13(16-8-4-7-15)18-14(17-10)11-5-2-3-6-12(11)19/h2-3,5-6,9,19H,4,7-8,15H2,1H3,(H,16,17,18) QAFMCTGHOXUNPP-UHFFFAOYSA-N 32333 (6Z)-6-[4-(3-aminopropylamino)-6-methyl-1H-pyrimidin-2-ylidene]-1-cyclohexa-2,4-dienone::(6Z)-6-[4-(3-aminopropylamino)-6-methyl-1H-pyrimidin-2-ylidene]cyclohexa-2,4-dien-1-one::(6Z)-6-[4-(3-azanylpropylamino)-6-methyl-1H-pyrimidin-2-ylidene]cyclohexa-2,4-dien-1-one::MLS000079650::SMR000040552::cid_5389142 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32333&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5389142 252615770 ZINC61870276 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80568 Oc1ccc2oc3c(CCCNC3=O)c2c1 InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15) AACFPJSJOWQNBN-UHFFFAOYSA-N 32334 7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofur[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofuro[2,3-c]azepin-1-one::7-oxidanyl-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::MLS000043346::SMR000019965::cid_755673 Serine/threonine-protein kinase PLK1 Homo sapiens 16664 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32334&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 755673 252615771 ZINC00210586 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80569 CCC(=O)Nc1c2CSCc2nn1-c1ccccc1C InChI=1S/C15H17N3OS/c1-3-14(19)16-15-11-8-20-9-12(11)17-18(15)13-7-5-4-6-10(13)2/h4-7H,3,8-9H2,1-2H3,(H,16,19) GHCQQPDRZPOLSG-UHFFFAOYSA-N 32335 MLS000087884::N-[2-(2-methylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl]propanamide::N-[2-(2-methylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]propanamide::N-[2-(o-tolyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]propionamide::SMR000024203::cid_3238449 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32335&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3238449 252615772 ZINC00190310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80570 CC(=O)Oc1cc(OC(C)=O)c2c(C)cc(=O)oc2c1 InChI=1S/C14H12O6/c1-7-4-13(17)20-12-6-10(18-8(2)15)5-11(14(7)12)19-9(3)16/h4-6H,1-3H3 XZMIXWYSAYXQPU-UHFFFAOYSA-N 32336 (5-acetyloxy-4-methyl-2-oxidanylidene-chromen-7-yl) ethanoate::(5-acetyloxy-4-methyl-2-oxochromen-7-yl) acetate::MLS000109851::SMR000105786::acetic acid (5-acetoxy-2-keto-4-methyl-chromen-7-yl) ester::acetic acid (5-acetyloxy-4-methyl-2-oxo-1-benzopyran-7-yl) ester::cid_390800 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32336&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 390800 252615773 ZINC00449258 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80571 CN[C@H]1C[C@H]2O[C@@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20+,26-,28-/m0/s1 HKSZLNNOFSGOKW-VCPDCAFQSA-N 32337 MLS000028832::SMR000058536::STAUROSPORINE::cid_5311103 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32337&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC,2PZY,2Z7R,3BKB,3CBL,3CD3,3CKX,3D7T,3FME 5311103 242052862 ZINC04095791 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80572 NC(=O)c1cn(C2OC(CO)C(O)C2O)c2ncnc(N)c12 InChI=1S/C12H15N5O5/c13-9-6-4(10(14)21)1-17(11(6)16-3-15-9)12-8(20)7(19)5(2-18)22-12/h1,3,5,7-8,12,18-20H,2H2,(H2,14,21)(H2,13,15,16) OBZJZDHRXBKKTJ-UHFFFAOYSA-N 32338 4-amino-7-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrate::4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-5-pyrrolo[2,3-d]pyrimidinecarboxamide;hydrate::4-amino-7-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrate::4-azanyl-7-[5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carboxamide;hydrate::MLS000517268::SANGIVAMYCIN::SMR000127424::cid_9549170 Serine/threonine-protein kinase PLK1 Homo sapiens 12058 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32338&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search SGV 3NYN,8OV2,7MTA,7MTB,7MT8,7MT9,6PJX,5AQZ,4TNB,6C9N 5153 252615774 ZINC03873911 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80573 CS(=O)(=O)N1CCN(CC1)c1ccccc1NC(=O)c1ccc(Br)o1 InChI=1S/C16H18BrN3O4S/c1-25(22,23)20-10-8-19(9-11-20)13-5-3-2-4-12(13)18-16(21)14-6-7-15(17)24-14/h2-7H,8-11H2,1H3,(H,18,21) LBOIZAZNPNCZBX-UHFFFAOYSA-N 32339 5-Bromo-furan-2-carboxylic acid [2-(4-methanesulfonyl-piperazin-1-yl)-phenyl]-amide::5-bromanyl-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]furan-2-carboxamide::5-bromo-N-[2-(4-mesylpiperazino)phenyl]-2-furamide::5-bromo-N-[2-(4-methylsulfonyl-1-piperazinyl)phenyl]-2-furancarboxamide::5-bromo-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]furan-2-carboxamide::MLS000123947::SMR000124483::cid_979832 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32339&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 979832 252615775 ZINC00624236 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80574 CCc1n[nH]c2cccc3c(OC)ccc1c23 InChI=1S/C14H14N2O/c1-3-11-9-7-8-13(17-2)10-5-4-6-12(14(9)10)16-15-11/h4-8,16H,3H2,1-2H3 OSHYRZXUHGNKMW-UHFFFAOYSA-N 32340 3-ethyl-6-methoxy-1H-benzo[de]cinnoline::MLS000533398::SMR000140796::cid_2876479 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32340&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2876479 242052863 ZINC04008439 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80575 Clc1cccc(c1)-c1ccc(o1)C(=O)Nc1ccc(CN2CCOCC2)cc1 InChI=1S/C22H21ClN2O3/c23-18-3-1-2-17(14-18)20-8-9-21(28-20)22(26)24-19-6-4-16(5-7-19)15-25-10-12-27-13-11-25/h1-9,14H,10-13,15H2,(H,24,26) XQJWTJLJEYIUDZ-UHFFFAOYSA-N 32341 5-(3-Chloro-phenyl)-furan-2-carboxylic acid (4-morpholin-4-ylmethyl-phenyl)-amide::5-(3-chlorophenyl)-N-[4-(4-morpholinylmethyl)phenyl]-2-furancarboxamide::5-(3-chlorophenyl)-N-[4-(morpholin-4-ylmethyl)phenyl]furan-2-carboxamide::5-(3-chlorophenyl)-N-[4-(morpholinomethyl)phenyl]-2-furamide::MLS000557592::SMR000148508::cid_2011756 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32341&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2011756 252615776 ZINC19683150 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80576 Nc1nc2ccc(c(N)c2s1)[N+]([O-])=O InChI=1S/C7H6N4O2S/c8-5-4(11(12)13)2-1-3-6(5)14-7(9)10-3/h1-2H,8H2,(H2,9,10) CVWJPFUAJJVCRP-UHFFFAOYSA-N 32342 (2-amino-6-nitro-1,3-benzothiazol-7-yl)amine::2,7-diamino-6-nitro-1,3-benzothiazole::6-nitro-1,3-benzothiazole-2,7-diamine::MLS000545094::SMR000163601::cid_5086667 Serine/threonine-protein kinase PLK1 Homo sapiens 410 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32342&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5086667 252615777 ZINC05335203 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 80577 Clc1cncc(Cl)c1N=NCc1ccncc1 InChI=1S/C11H8Cl2N4/c12-9-6-15-7-10(13)11(9)17-16-5-8-1-3-14-4-2-8/h1-4,6-7H,5H2 JHLKVKLVEXUKQO-UHFFFAOYSA-N 32343 (3,5-dichloro-4-pyridyl)-(4-pyridylmethyleneamino)amine::(3,5-dichloro-4-pyridyl)-[(E)-4-pyridylmethyleneamino]amine::3,5-bis(chloranyl)-N-(pyridin-4-ylmethylideneamino)pyridin-4-amine::3,5-dichloro-N-(pyridin-4-ylmethylideneamino)-4-pyridinamine::3,5-dichloro-N-(pyridin-4-ylmethylideneamino)pyridin-4-amine::MLS000583434::SMR000206620::cid_4438738::isonicotinaldehyde (3,5-dichloropyridin-4-yl)hydrazone Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2930RK5 aid1383 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32343&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91896150 252615778 ZINC34890789 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77878 Fc1ccc(Cn2nnnc2CN2CCN(CC2)C2CCCC2)cc1 InChI=1S/C18H25FN6/c19-16-7-5-15(6-8-16)13-25-18(20-21-22-25)14-23-9-11-24(12-10-23)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 NUVIKTFIUDCSBH-UHFFFAOYSA-N 41747 1-Cyclopentyl-4-[1-(4-fluoro-benzyl)-1H-tetrazol-5-ylmethyl]-piperazine::1-cyclopentyl-4-[[1-(4-fluorobenzyl)tetrazol-5-yl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-1,2,3,4-tetrazol-5-yl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-5-tetrazolyl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]tetrazol-5-yl]methyl]piperazine::MLS000073054::SMR000004983::cid_644709 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41747&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 644709 252622468 ZINC22583409 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77879 COc1ccc2c(C)n[nH]c3cccc1c23 InChI=1S/C13H12N2O/c1-8-9-6-7-12(16-2)10-4-3-5-11(13(9)10)15-14-8/h3-7,15H,1-2H3 MXCNJRIUQVTTPS-UHFFFAOYSA-N 31997 6-Methoxy-3-methyl-1H-benzo[de]cinnoline::MLS000027089::SMR000010302::cid_644992 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31997&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 644992 242052843 ZINC04008434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77880 CCC(=O)Nc1ccc(cc1)-c1nnc(SCC(=O)Nc2nccs2)n1C InChI=1S/C17H18N6O2S2/c1-3-13(24)19-12-6-4-11(5-7-12)15-21-22-17(23(15)2)27-10-14(25)20-16-18-8-9-26-16/h4-9H,3,10H2,1-2H3,(H,19,24)(H,18,20,25) CNOUHVBUCKBSLD-UHFFFAOYSA-N 41748 MLS000076456::N-[4-[4-methyl-5-[2-oxidanylidene-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[4-methyl-5-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[4-methyl-5-[[2-oxo-2-(2-thiazolylamino)ethyl]thio]-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[5-[[2-keto-2-(thiazol-2-ylamino)ethyl]thio]-4-methyl-1,2,4-triazol-3-yl]phenyl]propionamide::N-{4-[4-Methyl-5-(thiazol-2-ylcarbamoylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-phenyl}-propionamide::SMR000015120::cid_646718 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41748&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 646718 252622469 ZINC04510460 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77881 COc1ccccc1C1SCCN1S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C17H16F3NO3S2/c1-24-15-8-3-2-7-14(15)16-21(9-10-25-16)26(22,23)13-6-4-5-12(11-13)17(18,19)20/h2-8,11,16H,9-10H2,1H3 IANULKJFHGLGOX-UHFFFAOYSA-N 41749 2-(2-Methoxy-phenyl)-3-(3-trifluoromethyl-benzenesulfonyl)-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonyl-1,3-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonyl-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonylthiazolidine::MLS000030697::SMR000011601::cid_646735 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41749&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 646735 252622470 ZINC00887292 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77882 Clc1ccc(CC(=O)NCCN2CCCC2)cc1 InChI=1S/C14H19ClN2O/c15-13-5-3-12(4-6-13)11-14(18)16-7-10-17-8-1-2-9-17/h3-6H,1-2,7-11H2,(H,16,18) FCDXYGHRQACESV-UHFFFAOYSA-N 41750 2-(4-Chloro-phenyl)-N-(2-pyrrolidin-1-yl-ethyl)-acetamide::2-(4-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide;hydrochloride::2-(4-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)ethanamide;hydrochloride::2-(4-chlorophenyl)-N-(2-pyrrolidinoethyl)acetamide;hydrochloride::2-(4-chlorophenyl)-N-[2-(1-pyrrolidinyl)ethyl]acetamide;hydrochloride::MLS000075628::SMR000013881::cid_6603083 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41750&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 647301 252622471 ZINC02843177 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77883 CNC(=O)CC(C(O)=O)c1ccc(OCC(C)C)cc1 InChI=1S/C15H21NO4/c1-10(2)9-20-12-6-4-11(5-7-12)13(15(18)19)8-14(17)16-3/h4-7,10,13H,8-9H2,1-3H3,(H,16,17)(H,18,19) XQESYXHSGQLCNC-UHFFFAOYSA-N 41751 2-(4-Isobutoxy-phenyl)-N-methyl-succinamic acid::2-(4-isobutoxyphenyl)-4-keto-4-(methylamino)butyric acid::4-(methylamino)-2-[4-(2-methylpropoxy)phenyl]-4-oxidanylidene-butanoic acid::4-(methylamino)-2-[4-(2-methylpropoxy)phenyl]-4-oxobutanoic acid::MLS000068652::SMR000008612::cid_647848 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41751&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 647848 252622472 ZINC04411521 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77884 COc1ccc(cc1S(=O)(=O)Nc1ccc(Cl)cn1)C(C)C InChI=1S/C15H17ClN2O3S/c1-10(2)11-4-6-13(21-3)14(8-11)22(19,20)18-15-7-5-12(16)9-17-15/h4-10H,1-3H3,(H,17,18) XNYRYSBNCKGQLI-UHFFFAOYSA-N 41752 MLS000071127::N-(5-Chloro-pyridin-2-yl)-5-isopropyl-2-methoxy-benzenesulfonamide::N-(5-chloranylpyridin-2-yl)-2-methoxy-5-propan-2-yl-benzenesulfonamide::N-(5-chloro-2-pyridinyl)-2-methoxy-5-propan-2-ylbenzenesulfonamide::N-(5-chloro-2-pyridyl)-5-isopropyl-2-methoxy-benzenesulfonamide::N-(5-chloropyridin-2-yl)-2-methoxy-5-propan-2-ylbenzenesulfonamide::SMR000015187::cid_648225 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41752&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 648225 252622473 ZINC00384700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77885 Cc1ccc(NC(=O)C2CC=CCC2C(=O)N2CCCCC2)cc1 InChI=1S/C20H26N2O2/c1-15-9-11-16(12-10-15)21-19(23)17-7-3-4-8-18(17)20(24)22-13-5-2-6-14-22/h3-4,9-12,17-18H,2,5-8,13-14H2,1H3,(H,21,23) XWRKSKOBCZOXJA-UHFFFAOYSA-N 41753 6-(Piperidine-1-carbonyl)-cyclohex-3-enecarboxylic acid p-tolylamide::6-(piperidine-1-carbonyl)-N-(p-tolyl)cyclohex-3-ene-1-carboxamide::MLS000071126::N-(4-methylphenyl)-6-(piperidine-1-carbonyl)cyclohex-3-ene-1-carboxamide::N-(4-methylphenyl)-6-[oxo(1-piperidinyl)methyl]-1-cyclohex-3-enecarboxamide::N-(4-methylphenyl)-6-piperidin-1-ylcarbonyl-cyclohex-3-ene-1-carboxamide::SMR000010710::cid_648286 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41753&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 648286 252622474 ZINC00054230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77886 O=C1C(Nc2ccccc12)=C1C(=O)c2ccccc2C1=O InChI=1S/C17H9NO3/c19-15-9-5-1-2-6-10(9)16(20)13(15)14-17(21)11-7-3-4-8-12(11)18-14/h1-8,18H XXSJHAICOWNQBL-UHFFFAOYSA-N 32004 2-(3-Oxo-1,3-dihydro-indol-2-ylidene)-indan-1,3-dione::2-(3-ketoindolin-2-ylidene)indane-1,3-quinone::2-(3-oxidanylidene-1H-indol-2-ylidene)indene-1,3-dione::2-(3-oxo-1H-indol-2-ylidene)indene-1,3-dione::MLS000071738::SMR000010447::cid_649556 Serine/threonine-protein kinase PLK1 Homo sapiens 29131.00052 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32004&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 649556 252615466 ZINC06529695 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77887 COc1ccc(Cn2c3ccccc3sc2=O)cc1 InChI=1S/C15H13NO2S/c1-18-12-8-6-11(7-9-12)10-16-13-4-2-3-5-14(13)19-15(16)17/h2-9H,10H2,1H3 MHFZFKZXERZAKK-UHFFFAOYSA-N 41754 3-(4-Methoxy-benzyl)-3H-benzothiazol-2-one::3-[(4-methoxyphenyl)methyl]-1,3-benzothiazol-2-one::3-p-anisyl-1,3-benzothiazol-2-one::MLS000035042::SMR000015012::cid_649921 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41754&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 649921 252622475 ZINC00814287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77888 Cn1c2cccc3C(=O)c4ccccc4-c(c(NCCO)c1=O)c23 InChI=1S/C19H16N2O3/c1-21-14-8-4-7-13-15(14)16(17(19(21)24)20-9-10-22)11-5-2-3-6-12(11)18(13)23/h2-8,20,22H,9-10H2,1H3 JHRNUMVGSNJFOB-UHFFFAOYSA-N 32006 1-(2-Hydroxy-ethylamino)-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione::MLS000076121::SMR000013433::cid_650462 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32006&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 650462 242052845 ZINC18141610 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77889 Cc1ccc2cc(C(N3CCN(CC3)c3ccccc3)c3nnnn3C3CCCC3)c(=O)[nH]c2c1 InChI=1S/C27H31N7O/c1-19-11-12-20-18-23(27(35)28-24(20)17-19)25(26-29-30-31-34(26)22-9-5-6-10-22)33-15-13-32(14-16-33)21-7-3-2-4-8-21/h2-4,7-8,11-12,17-18,22,25H,5-6,9-10,13-16H2,1H3,(H,28,35) ADHPEXKPDZDCGO-UHFFFAOYSA-N 41755 3-[(1-Cyclopentyl-1H-tetrazol-5-yl)-(4-phenyl-piperazin-1-yl)-methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyl-5-tetrazolyl)-(4-phenyl-1-piperazinyl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazino)methyl]-7-methyl-carbostyril::MLS000071942::SMR000002493::cid_650853 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41755&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 650853 252622476 ZINC19221931 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77890 CCn1c(SCC(N)=O)nnc1-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C17H24N6O3S2/c1-3-23-16(19-20-17(23)27-12-15(18)24)13-4-6-14(7-5-13)28(25,26)22-10-8-21(2)9-11-22/h4-7H,3,8-12H2,1-2H3,(H2,18,24) ZALDGZDSUBRSKA-UHFFFAOYSA-N 41756 2-[[4-ethyl-5-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide::2-[[4-ethyl-5-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,2,4-triazol-3-yl]sulfanyl]ethanamide::2-[[4-ethyl-5-[4-(4-methylpiperazino)sulfonylphenyl]-1,2,4-triazol-3-yl]thio]acetamide::2-[[4-ethyl-5-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,2,4-triazol-3-yl]thio]acetamide::2-{4-Ethyl-5-[4-(4-methyl-piperazine-1-sulfonyl)-phenyl]-4H-[1,2,4]triazol-3-ylsulfanyl}-acetamide::MLS000072580::SMR000002266::cid_651311 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41756&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 651311 252622477 ZINC36296032 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77891 CCC(=O)N1CCN(CC1)c1ccc(NC(=O)c2ccc3OCOc3c2)cc1 InChI=1S/C21H23N3O4/c1-2-20(25)24-11-9-23(10-12-24)17-6-4-16(5-7-17)22-21(26)15-3-8-18-19(13-15)28-14-27-18/h3-8,13H,2,9-12,14H2,1H3,(H,22,26) OHJWZEMHHPSNLZ-UHFFFAOYSA-N 41757 Benzo[1,3]dioxole-5-carboxylic acid [4-(4-propionyl-piperazin-1-yl)-phenyl]-amide::MLS000033956::N-[4-(4-propanoylpiperazin-1-yl)phenyl]-1,3-benzodioxole-5-carboxamide::N-[4-(4-propionylpiperazino)phenyl]-piperonylamide::N-[4-[4-(1-oxopropyl)-1-piperazinyl]phenyl]-1,3-benzodioxole-5-carboxamide::SMR000014586::cid_652011 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41757&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 652011 252622478 ZINC00809572 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77892 CCOC(=O)Cc1csc(NC(=O)CSc2nnc(o2)-c2ccc(F)cc2)n1 InChI=1S/C17H15FN4O4S2/c1-2-25-14(24)7-12-8-27-16(19-12)20-13(23)9-28-17-22-21-15(26-17)10-3-5-11(18)6-4-10/h3-6,8H,2,7,9H2,1H3,(H,19,20,23) QBJGPSUBFYSVCP-UHFFFAOYSA-N 41758 (2-{2-[5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-acetylamino}-thiazol-4-yl)-acetic acid ethyl ester::2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester::2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetyl]amino]thiazol-4-yl]acetic acid ethyl ester::MLS000071801::SMR000003120::cid_653271::ethyl 2-[2-[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]-1,3-thiazol-4-yl]ethanoate::ethyl 2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]-1,3-thiazol-4-yl]acetate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41758&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 653271 252622479 ZINC04375512 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77893 COc1ccc(CC2NCCC3(O)CCCCC23)cc1 InChI=1S/C17H25NO2/c1-20-14-7-5-13(6-8-14)12-16-15-4-2-3-9-17(15,19)10-11-18-16/h5-8,15-16,18-19H,2-4,9-12H2,1H3 PANQQHGRCGEZCM-UHFFFAOYSA-N 41759 1-(4-Methoxy-benzyl)-octahydro-isoquinolin-4a-ol::1-[(4-methoxyphenyl)methyl]-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol::1-p-anisyl-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol::MLS000074557::SMR000014065::cid_655005 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41759&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655005 252622480 ZINC04290960 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77894 OC(=O)C1(CCC(=O)C1)c1ccccc1 InChI=1S/C12H12O3/c13-10-6-7-12(8-10,11(14)15)9-4-2-1-3-5-9/h1-5H,6-8H2,(H,14,15) GZFDVSDSPLDDJS-UHFFFAOYSA-N 41760 3-Oxo-1-phenyl-cyclopentanecarboxylic acid::3-keto-1-phenyl-cyclopentanecarboxylic acid::3-oxidanylidene-1-phenyl-cyclopentane-1-carboxylic acid::3-oxo-1-phenyl-1-cyclopentanecarboxylic acid::3-oxo-1-phenylcyclopentane-1-carboxylic acid::MLS000032541::SMR000009429::cid_655176 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41760&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655176 252622481 ZINC00328209 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77895 Cn1c2ncn(CCCc3ccccc3)c2c(=O)n(C)c1=O InChI=1S/C16H18N4O2/c1-18-14-13(15(21)19(2)16(18)22)20(11-17-14)10-6-9-12-7-4-3-5-8-12/h3-5,7-8,11H,6,9-10H2,1-2H3 COZBOOBOYNKJBR-UHFFFAOYSA-N 41761 1,3-Dimethyl-7-(3-phenyl-propyl)-3,7-dihydro-purine-2,6-dione::1,3-dimethyl-7-(3-phenylpropyl)purine-2,6-dione::1,3-dimethyl-7-(3-phenylpropyl)xanthine::MLS000075466::SMR000010660::cid_655558 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41761&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655558 252622482 ZINC00380557 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77896 CCCSc1nc(N2CCOCC2)c2CCCCc2c1C#N InChI=1S/C17H23N3OS/c1-2-11-22-17-15(12-18)13-5-3-4-6-14(13)16(19-17)20-7-9-21-10-8-20/h2-11H2,1H3 GBLQTUPKPFDZPX-UHFFFAOYSA-N 37310 1-(4-morpholinyl)-3-(propylthio)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::1-morpholin-4-yl-3-propylsulfanyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::1-morpholino-3-(propylthio)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::MLS000071300::SMR000039075::cid_658137 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37310&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 658137 252618281 ZINC20826934 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77897 CC1(C)CC(=O)C=C(C1)NCc1ccncc1 InChI=1S/C14H18N2O/c1-14(2)8-12(7-13(17)9-14)16-10-11-3-5-15-6-4-11/h3-7,16H,8-10H2,1-2H3 CEJRNMJRBUFLIR-UHFFFAOYSA-N 41762 5,5-dimethyl-3-(4-pyridylmethylamino)cyclohex-2-en-1-one::5,5-dimethyl-3-(pyridin-4-ylmethylamino)-1-cyclohex-2-enone::5,5-dimethyl-3-(pyridin-4-ylmethylamino)cyclohex-2-en-1-one::MLS000038448::SMR000036470::cid_658329 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41762&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 658329 252622483 ZINC04083056 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77898 Cc1ccc(cc1)-n1c(O)c(C=NCCN2CCOCC2)c(=O)[nH]c1=O InChI=1S/C18H22N4O4/c1-13-2-4-14(5-3-13)22-17(24)15(16(23)20-18(22)25)12-19-6-7-21-8-10-26-11-9-21/h2-5,12,24H,6-11H2,1H3,(H,20,23,25) KJUSUBNBSAGLQB-UHFFFAOYSA-N 41763 (5E)-1-(4-methylphenyl)-5-[(2-morpholin-4-ylethylamino)methylidene]-1,3-diazinane-2,4,6-trione::(5E)-1-(4-methylphenyl)-5-[[2-(4-morpholinyl)ethylamino]methylidene]-1,3-diazinane-2,4,6-trione::(5E)-5-[(2-morpholinoethylamino)methylene]-1-(p-tolyl)barbituric acid::MLS000036795::SMR000040602::cid_5389133 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41763&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5389133 252622484 ZINC19994468 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77899 COC(=O)CCc1c(C)[nH]c(=S)[nH]c1=O InChI=1S/C9H12N2O3S/c1-5-6(3-4-7(12)14-2)8(13)11-9(15)10-5/h3-4H2,1-2H3,(H2,10,11,13,15) ISRRLTIEWOHRNX-UHFFFAOYSA-N 41764 3-(4-keto-6-methyl-2-thioxo-1H-pyrimidin-5-yl)propionic acid methyl ester::3-(6-methyl-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanoic acid methyl ester::MLS000077573::SMR000034647::cid_660631::methyl 3-(6-methyl-4-oxidanylidene-2-sulfanylidene-1H-pyrimidin-5-yl)propanoate::methyl 3-(6-methyl-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41764&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 660631 252622485 ZINC17887074 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77900 CCOC(=O)c1ccc(NC(=O)c2c(O)[nH]c(=O)[nH]c2=O)cc1 InChI=1S/C14H13N3O6/c1-2-23-13(21)7-3-5-8(6-4-7)15-10(18)9-11(19)16-14(22)17-12(9)20/h3-6H,2H2,1H3,(H,15,18)(H3,16,17,19,20,22) XWZUFKMEGYKBSH-UHFFFAOYSA-N 41765 4-[(6-hydroxy-2,4-diketo-1H-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::4-[[(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid ethyl ester::MLS000040367::SMR000058126::cid_662817::ethyl 4-[(6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carbonyl)amino]benzoate::ethyl 4-[[6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41765&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 662817 252622486 ZINC06499020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77901 FC(F)(F)C1(NC(=O)c2ccco2)NC(=O)N(CC2CCCCC2)C1=O InChI=1S/C16H18F3N3O4/c17-16(18,19)15(20-12(23)11-7-4-8-26-11)13(24)22(14(25)21-15)9-10-5-2-1-3-6-10/h4,7-8,10H,1-3,5-6,9H2,(H,20,23)(H,21,25) VOKFQDFDAZVPOY-UHFFFAOYSA-N 41766 MLS000040678::N-[1-(cyclohexylmethyl)-2,5-bis(oxidanylidene)-4-(trifluoromethyl)imidazolidin-4-yl]furan-2-carboxamide::N-[1-(cyclohexylmethyl)-2,5-diketo-4-(trifluoromethyl)imidazolidin-4-yl]-2-furamide::N-[1-(cyclohexylmethyl)-2,5-dioxo-4-(trifluoromethyl)-4-imidazolidinyl]-2-furancarboxamide::N-[1-(cyclohexylmethyl)-2,5-dioxo-4-(trifluoromethyl)imidazolidin-4-yl]furan-2-carboxamide::SMR000044833::cid_663976 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41766&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 663976 252622487 ZINC02420569 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77902 O=C(CN1C(=O)c2ccccc2C1=O)N1CCN(CC1)c1nnc(-c2ccccc2)c2ccccc12 InChI=1S/C28H23N5O3/c34-24(18-33-27(35)22-12-6-7-13-23(22)28(33)36)31-14-16-32(17-15-31)26-21-11-5-4-10-20(21)25(29-30-26)19-8-2-1-3-9-19/h1-13H,14-18H2 IXQKLGBUUZVOSE-UHFFFAOYSA-N 41767 2-[2-keto-2-[4-(4-phenylphthalazin-1-yl)piperazino]ethyl]isoindoline-1,3-quinone::2-[2-oxidanylidene-2-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]ethyl]isoindole-1,3-dione::2-[2-oxo-2-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethyl]isoindole-1,3-dione::2-[2-oxo-2-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]ethyl]isoindole-1,3-dione::MLS000080299::SMR000035392::cid_664563 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41767&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 664563 252622488 ZINC02393309 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77903 CC(C)N(Cc1cc2ccccc2[nH]c1=O)C(=O)c1cccnc1 InChI=1S/C19H19N3O2/c1-13(2)22(19(24)15-7-5-9-20-11-15)12-16-10-14-6-3-4-8-17(14)21-18(16)23/h3-11,13H,12H2,1-2H3,(H,21,23) YRUNVDQFBNTJJU-UHFFFAOYSA-N 41768 MLS000040805::N-[(2-oxidanylidene-1H-quinolin-3-yl)methyl]-N-propan-2-yl-pyridine-3-carboxamide::N-[(2-oxo-1H-quinolin-3-yl)methyl]-N-propan-2-yl-3-pyridinecarboxamide::N-[(2-oxo-1H-quinolin-3-yl)methyl]-N-propan-2-ylpyridine-3-carboxamide::N-isopropyl-N-[(2-keto-1H-quinolin-3-yl)methyl]nicotinamide::SMR000045745::cid_664836 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41768&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 664836 252622489 ZINC08619780 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77904 CN1CC2(Cc3cc(C)ccc13)C(=O)NC(=O)N(C2=O)c1ccccc1C InChI=1S/C21H21N3O3/c1-13-8-9-17-15(10-13)11-21(12-23(17)3)18(25)22-20(27)24(19(21)26)16-7-5-4-6-14(16)2/h4-10H,11-12H2,1-3H3,(H,22,25,27) PWOCMFZIMZKXHI-UHFFFAOYSA-N 41769 1',6'-dimethyl-1-(2-methylphenyl)spiro[1,3-diazinane-5,3'-2,4-dihydroquinoline]-2,4,6-trione::1,6-dimethyl-1'-(o-tolyl)spiro[2,4-dihydroquinoline-3,5'-hexahydropyrimidine]-2',4',6'-trione::MLS000042257::SMR000047525::cid_666205 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41769&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 666205 252622490 ZINC09087711 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77905 CN1C(=O)N(C)C(=O)C2(Sc3ccccc3C2=O)C1=O InChI=1S/C13H10N2O4S/c1-14-10(17)13(11(18)15(2)12(14)19)9(16)7-5-3-4-6-8(7)20-13/h3-6H,1-2H3 AOJMVFZSESQXSW-UHFFFAOYSA-N 41770 1',3'-dimethylspiro[benzothiophene-2,5'-hexahydropyrimidine]-2',3,4',6'-diquinone::1,3-dimethylspiro[1,3-diazinane-5,2'-1-benzothiophene]-2,3',4,6-tetrone::MLS000055669::SMR000060674::cid_2324605 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41770&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2324605 252622491 ZINC03199325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77906 C(Nc1ccccc1)c1nnc2CCCCCn12 InChI=1S/C14H18N4/c1-3-7-12(8-4-1)15-11-14-17-16-13-9-5-2-6-10-18(13)14/h1,3-4,7-8,15H,2,5-6,9-11H2 OOJNELXWRKRYSI-UHFFFAOYSA-N 41771 MLS000057041::N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)aniline::SMR000060400::cid_2310790::phenyl(6,7,8,9-tetrahydro-5H-[1,2,4]triazol[4,3-a]azepin-3-ylmethyl)amine Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41771&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2310790 252622492 ZINC03171849 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77907 CCNC(=O)NC(=O)C(C)OC(=O)c1cccnc1SC InChI=1S/C13H17N3O4S/c1-4-14-13(19)16-10(17)8(2)20-12(18)9-6-5-7-15-11(9)21-3/h5-8H,4H2,1-3H3,(H2,14,16,17,19) MODWYEMRBXFKPQ-UHFFFAOYSA-N 41772 2-(methylthio)-3-pyridinecarboxylic acid [1-(ethylcarbamoylamino)-1-oxopropan-2-yl] ester::2-(methylthio)nicotinic acid [2-(ethylcarbamoylamino)-2-keto-1-methyl-ethyl] ester::MLS000053625::SMR000066587::[1-(ethylcarbamoylamino)-1-oxidanylidene-propan-2-yl] 2-methylsulfanylpyridine-3-carboxylate::[1-(ethylcarbamoylamino)-1-oxopropan-2-yl] 2-methylsulfanylpyridine-3-carboxylate::cid_2998051 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41772&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2998051 252622493 ZINC02640951 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77908 OC(=O)c1ccc(CNC(=O)CN2C(=O)COc3ccccc23)cc1 InChI=1S/C18H16N2O5/c21-16(19-9-12-5-7-13(8-6-12)18(23)24)10-20-14-3-1-2-4-15(14)25-11-17(20)22/h1-8H,9-11H2,(H,19,21)(H,23,24) BXGZDQAFFSEREH-UHFFFAOYSA-N 41773 4-[[2-(3-oxidanylidene-1,4-benzoxazin-4-yl)ethanoylamino]methyl]benzoic acid::4-[[[1-oxo-2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]amino]methyl]benzoic acid::4-[[[2-(3-keto-1,4-benzoxazin-4-yl)acetyl]amino]methyl]benzoic acid::4-[[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]methyl]benzoic acid::MLS000056601::SMR000064585::cid_2526829 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41773&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2526829 252622494 ZINC03407963 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77909 Brc1ccc(s1)S(=O)(=O)NCC(=O)N1CCCC1 InChI=1S/C10H13BrN2O3S2/c11-8-3-4-10(17-8)18(15,16)12-7-9(14)13-5-1-2-6-13/h3-4,12H,1-2,5-7H2 YFADDZBVQYUEMH-UHFFFAOYSA-N 41774 5-bromanyl-N-(2-oxidanylidene-2-pyrrolidin-1-yl-ethyl)thiophene-2-sulfonamide::5-bromo-N-(2-keto-2-pyrrolidino-ethyl)thiophene-2-sulfonamide::5-bromo-N-(2-oxo-2-pyrrolidin-1-ylethyl)thiophene-2-sulfonamide::5-bromo-N-[2-oxo-2-(1-pyrrolidinyl)ethyl]-2-thiophenesulfonamide::MLS000090539::SMR000025143::cid_3237147 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41774&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3237147 252622495 ZINC02602308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77910 OC1(NC(=O)c2ccccc2)C(=O)c2ccccc2C1=O InChI=1S/C16H11NO4/c18-13-11-8-4-5-9-12(11)14(19)16(13,21)17-15(20)10-6-2-1-3-7-10/h1-9,21H,(H,17,20) FICSYWUBABJDHB-UHFFFAOYSA-N 32085 MLS000085603::N-(2-hydroxy-1,3-diketo-indan-2-yl)benzamide::N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide::N-(2-hydroxy-1,3-dioxo-2-indenyl)benzamide::N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide::N-[2-oxidanyl-1,3-bis(oxidanylidene)inden-2-yl]benzamide::SMR000020538::cid_3237318 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3237318 252615537 ZINC03647975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77911 CC(C(=O)N1CCCCC1)n1nc(C)c2sc3ccccc3c2c1=O InChI=1S/C19H21N3O2S/c1-12-17-16(14-8-4-5-9-15(14)25-17)19(24)22(20-12)13(2)18(23)21-10-6-3-7-11-21/h4-5,8-9,13H,3,6-7,10-11H2,1-2H3 DOTOMXRXJJNUOG-UHFFFAOYSA-N 35390 2-(2-keto-1-methyl-2-piperidino-ethyl)-4-methyl-benzothiopheno[2,3-d]pyridazin-1-one::4-methyl-2-(1-methyl-2-oxo-2-piperidin-1-ylethyl)[1]benzothieno[2,3-d]pyridazin-1(2H)-one::4-methyl-2-(1-oxidanylidene-1-piperidin-1-yl-propan-2-yl)-[1]benzothiolo[2,3-d]pyridazin-1-one::4-methyl-2-(1-oxo-1-piperidin-1-ylpropan-2-yl)-[1]benzothiolo[2,3-d]pyridazin-1-one::4-methyl-2-[1-oxo-1-(1-piperidinyl)propan-2-yl]-[1]benzothiolo[2,3-d]pyridazin-1-one::MLS000093662::SMR000029280::cid_3238280 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35390&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3238280 252617659 ZINC04103920 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77912 CCn1ccc(n1)C(=O)Nc1ccc(cc1)N(C)C(C)=O InChI=1S/C15H18N4O2/c1-4-19-10-9-14(17-19)15(21)16-12-5-7-13(8-6-12)18(3)11(2)20/h5-10H,4H2,1-3H3,(H,16,21) ITHLLNAEGXABNZ-UHFFFAOYSA-N 41775 MLS000043435::N-[4-[acetyl(methyl)amino]phenyl]-1-ethyl-3-pyrazolecarboxamide::N-[4-[acetyl(methyl)amino]phenyl]-1-ethyl-pyrazole-3-carboxamide::N-[4-[acetyl(methyl)amino]phenyl]-1-ethylpyrazole-3-carboxamide::N-[4-[ethanoyl(methyl)amino]phenyl]-1-ethyl-pyrazole-3-carboxamide::N-{4-[acetyl(methyl)amino]phenyl}-1-ethyl-1H-pyrazole-3-carboxamide::SMR000020252::cid_3238912 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41775&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3238912 252622496 ZINC00205154 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77913 O=C1CCn2cnc3cccc4ccc1c2c34 InChI=1S/C14H10N2O/c17-12-6-7-16-8-15-11-3-1-2-9-4-5-10(12)14(16)13(9)11/h1-5,8H,6-7H2 HBIWCEFNSGRROL-UHFFFAOYSA-N 34608 7,8-dihydro-9H-pyrido[1,2,3-cd]perimidin-9-one::MLS000044006::SMR000021417::cid_677487 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34608&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 677487 242052897 ZINC00041157 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77914 CCn1cnc2sc(C(=O)N3CCN(CC3)c3ccc(OC)cc3)c(C)c2c1=O InChI=1S/C21H24N4O3S/c1-4-23-13-22-19-17(20(23)26)14(2)18(29-19)21(27)25-11-9-24(10-12-25)15-5-7-16(28-3)8-6-15/h5-8,13H,4,9-12H2,1-3H3 OUTGETYLJYFRDG-UHFFFAOYSA-N 41776 3-ethyl-6-[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl-5-methyl-thieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methyl-thieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methylthieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]-5-methyl-4-thieno[2,3-d]pyrimidinone::3-ethyl-6-{[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl}-5-methylthieno[2,3-d]pyrimidin-4(3H)-one::MLS000089815::SMR000024433::cid_3241114 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41776&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3241114 252622497 ZINC04056947 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77915 O=C(Nc1ccccn1)C1CCN(CC1)S(=O)(=O)c1cccc2nonc12 InChI=1S/C17H17N5O4S/c23-17(19-15-6-1-2-9-18-15)12-7-10-22(11-8-12)27(24,25)14-5-3-4-13-16(14)21-26-20-13/h1-6,9,12H,7-8,10-11H2,(H,18,19,23) PZMQVMXXJJCIDZ-UHFFFAOYSA-N 41777 1-(2,1,3-benzoxadiazol-4-ylsulfonyl)-N-(2-pyridinyl)-4-piperidinecarboxamide::1-(2,1,3-benzoxadiazol-4-ylsulfonyl)-N-pyridin-2-yl-piperidine-4-carboxamide::1-(2,1,3-benzoxadiazol-4-ylsulfonyl)-N-pyridin-2-ylpiperidine-4-carboxamide::1-benzofurazan-4-ylsulfonyl-N-(2-pyridyl)isonipecotamide::MLS000090584::SMR000025188::cid_3241494 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41777&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3241494 252622498 ZINC02467659 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77916 NC(=O)C1(CCN(CC1)C(=O)NC1CCCCC1)N1CCCCC1 InChI=1S/C18H32N4O2/c19-16(23)18(22-11-5-2-6-12-22)9-13-21(14-10-18)17(24)20-15-7-3-1-4-8-15/h15H,1-14H2,(H2,19,23)(H,20,24) LNEFWEVPXMONGI-UHFFFAOYSA-N 41778 1-N-cyclohexyl-4-piperidin-1-ylpiperidine-1,4-dicarboxamide::MLS000094250::N-cyclohexyl-4-piperidino-piperidine-1,4-dicarboxamide::N1-cyclohexyl-4-(1-piperidinyl)piperidine-1,4-dicarboxamide::N1-cyclohexyl-4-piperidin-1-yl-piperidine-1,4-dicarboxamide::N~1~'-cyclohexyl-1,4'-bipiperidine-1',4'-dicarboxamide::SMR000029840::cid_3242636 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41778&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3242636 252622499 ZINC04077168 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77917 CC(=O)N1CCc2cc(Br)cc(c12)S(=O)(=O)NCc1ccccn1 InChI=1S/C16H16BrN3O3S/c1-11(21)20-7-5-12-8-13(17)9-15(16(12)20)24(22,23)19-10-14-4-2-3-6-18-14/h2-4,6,8-9,19H,5,7,10H2,1H3 WARNLUCAHADWDF-UHFFFAOYSA-N 41779 1-acetyl-5-bromo-N-(2-pyridinylmethyl)-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-(2-pyridylmethyl)indoline-7-sulfonamide::1-acetyl-5-bromo-N-(pyridin-2-ylmethyl)-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-(pyridin-2-ylmethyl)indoline-7-sulfonamide::5-bromanyl-1-ethanoyl-N-(pyridin-2-ylmethyl)-2,3-dihydroindole-7-sulfonamide::MLS000086257::SMR000021766::cid_3242806 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41779&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3242806 252622500 ZINC02456155 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77918 CC(C)OCCCNC(=O)c1ccc(NC(=O)C2CCCO2)cc1 InChI=1S/C18H26N2O4/c1-13(2)23-12-4-10-19-17(21)14-6-8-15(9-7-14)20-18(22)16-5-3-11-24-16/h6-9,13,16H,3-5,10-12H2,1-2H3,(H,19,21)(H,20,22) NNNDGXJQBMEKOL-UHFFFAOYSA-N 41780 MLS000086701::N-(4-{[(3-isopropoxypropyl)amino]carbonyl}phenyl)tetrahydrofuran-2-carboxamide::N-[4-(3-isopropoxypropylcarbamoyl)phenyl]tetrahydrofuran-2-carboxamide::N-[4-(3-propan-2-yloxypropylcarbamoyl)phenyl]oxolane-2-carboxamide::N-[4-[oxo-(3-propan-2-yloxypropylamino)methyl]phenyl]-2-oxolanecarboxamide::SMR000022741::cid_3244061 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41780&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3244061 252622501 ZINC03906325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77919 Cc1ccc(Cl)cc1N1CCN(CC1)S(=O)(=O)c1ccc2n(C)c(=O)oc2c1 InChI=1S/C19H20ClN3O4S/c1-13-3-4-14(20)11-17(13)22-7-9-23(10-8-22)28(25,26)15-5-6-16-18(12-15)27-19(24)21(16)2/h3-6,11-12H,7-10H2,1-2H3 CPYIYHOKMIZHAD-UHFFFAOYSA-N 41781 6-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[4-(5-chloro-2-methyl-phenyl)piperazino]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[[4-(5-chloro-2-methylphenyl)-1-piperazinyl]sulfonyl]-3-methyl-1,3-benzoxazol-2-one::6-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-3-methyl-1,3-benzoxazol-2(3H)-one::MLS000092349::SMR000027426::cid_2983872 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41781&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2983872 252622502 ZINC04058144 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77920 CCC(Sc1nc2nnc(C)c2c(N)n1-c1cccc(Cl)c1)C(=O)NCCOC InChI=1S/C19H23ClN6O2S/c1-4-14(18(27)22-8-9-28-3)29-19-23-17-15(11(2)24-25-17)16(21)26(19)13-7-5-6-12(20)10-13/h5-7,10,14H,4,8-9,21H2,1-3H3,(H,22,27) LXNUZWHEMOKYNJ-UHFFFAOYSA-N 41782 2-[4-amino-5-(3-chlorophenyl)-3-methylpyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl-N-(2-methoxyethyl)butanamide::2-[4-azanyl-5-(3-chlorophenyl)-3-methyl-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl-N-(2-methoxyethyl)butanamide::2-[[4-amino-5-(3-chlorophenyl)-3-methyl-6-pyrazolo[3,4-d]pyrimidinyl]thio]-N-(2-methoxyethyl)butanamide::2-[[4-amino-5-(3-chlorophenyl)-3-methyl-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-N-(2-methoxyethyl)butyramide::2-{[5-(3-chlorophenyl)-4-imino-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio}-N-(2-methoxyethyl)butanamide::MLS000047108::SMR000033119::cid_3245367 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41782&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3245367 252622503 ZINC49539778 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77921 CC1Cn2c(S1)nnc2-c1cc2ccccc2cc1O InChI=1S/C15H13N3OS/c1-9-8-18-14(16-17-15(18)20-9)12-6-10-4-2-3-5-11(10)7-13(12)19/h2-7,9,19H,8H2,1H3 QTSVSHZDVQRJCV-UHFFFAOYSA-N 41783 (3E)-3-(6-methyl-5,6-dihydro-2H-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-ylidene)naphthalen-2-one::(3E)-3-(6-methyl-5,6-dihydro-2H-thiazolo[2,3-c][1,2,4]triazol-3-ylidene)-2-naphthalenone::(3E)-3-(6-methyl-5,6-dihydro-2H-thiazolo[2,3-c][1,2,4]triazol-3-ylidene)naphthalen-2-one::3-(6-methyl-5,6-dihydro[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)-2-naphthol::MLS000066435::SMR000081402::cid_5771713 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41783&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5771713 252622504 ZINC12467700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77922 Cc1nn2c(ncc(NC(=O)c3ccc(C)cc3)c2=O)s1 InChI=1S/C14H12N4O2S/c1-8-3-5-10(6-4-8)12(19)16-11-7-15-14-18(13(11)20)17-9(2)21-14/h3-7H,1-2H3,(H,16,19) MLXGFKLTQYTDMA-UHFFFAOYSA-N 41784 4-methyl-N-(2-methyl-5-oxidanylidene-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::4-methyl-N-(2-methyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::4-methyl-N-(2-methyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::MLS000100118::N-(5-keto-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)-4-methyl-benzamide::SMR000081907::cid_2233157 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41784&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2233157 252622505 ZINC02880962 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77923 CC(C)=CC(=O)NCCc1ccccc1 InChI=1S/C13H17NO/c1-11(2)10-13(15)14-9-8-12-6-4-3-5-7-12/h3-7,10H,8-9H2,1-2H3,(H,14,15) FCKSARQRQMJRHX-UHFFFAOYSA-N 41785 3-methyl-N-(2-phenylethyl)-2-butenamide::3-methyl-N-(2-phenylethyl)but-2-enamide::3-methyl-N-phenethyl-but-2-enamide::MLS000089152::SMR000072849::cid_731815 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41785&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 731815 252622506 ZINC00145632 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77924 Cc1ccccc1NS(=O)(=O)c1cc(ccc1C)C(=O)NCc1ccco1 InChI=1S/C20H20N2O4S/c1-14-6-3-4-8-18(14)22-27(24,25)19-12-16(10-9-15(19)2)20(23)21-13-17-7-5-11-26-17/h3-12,22H,13H2,1-2H3,(H,21,23) YRQJWUOJVVUYMP-UHFFFAOYSA-N 41786 MLS000052108::N-(2-furanylmethyl)-4-methyl-3-[(2-methylphenyl)sulfamoyl]benzamide::N-(2-furfuryl)-4-methyl-3-(o-tolylsulfamoyl)benzamide::N-(2-furylmethyl)-4-methyl-3-{[(2-methylphenyl)amino]sulfonyl}benzamide::N-(furan-2-ylmethyl)-4-methyl-3-[(2-methylphenyl)sulfamoyl]benzamide::SMR000081430::cid_1251601 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41786&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1251601 252622507 ZINC01061586 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77925 CCOC(=O)c1cc2C(=O)c3ccccc3-n2c1N InChI=1S/C14H12N2O3/c1-2-19-14(18)9-7-11-12(17)8-5-3-4-6-10(8)16(11)13(9)15/h3-7H,2,15H2,1H3 NLOFNKPOURZRLR-UHFFFAOYSA-N 41787 1-amino-4-keto-pyrrol[1,2-a]indole-2-carboxylic acid ethyl ester::1-amino-4-oxo-2-pyrrolo[1,2-a]indolecarboxylic acid ethyl ester::MLS000058819::SMR000069085::cid_611015::ethyl 1-amino-4-oxopyrrolo[1,2-a]indole-2-carboxylate::ethyl 1-azanyl-4-oxidanylidene-pyrrolo[1,2-a]indole-2-carboxylate::ethyl 3-amino-9-oxo-9H-pyrrolo[1,2-a]indole-2-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41787&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 611015 252622508 ZINC00285539 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77926 C\C(=C/C(=O)Nc1cc(C)on1)c1ccccc1 InChI=1S/C14H14N2O2/c1-10(12-6-4-3-5-7-12)8-14(17)15-13-9-11(2)18-16-13/h3-9H,1-2H3,(H,15,16,17)/b10-8+ PEFNMKYDZNYGDS-CSKARUKUSA-N 41788 (E)-N-(5-methyl-1,2-oxazol-3-yl)-3-phenyl-but-2-enamide::(E)-N-(5-methyl-1,2-oxazol-3-yl)-3-phenylbut-2-enamide::(E)-N-(5-methyl-3-isoxazolyl)-3-phenyl-2-butenamide::(E)-N-(5-methylisoxazol-3-yl)-3-phenyl-but-2-enamide::MLS000089139::SMR000072835::cid_891479 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41788&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 891479 252622509 ZINC00467035 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77927 CCc1nc2cc(Cl)c(Cl)cc2[nH]1 InChI=1S/C9H8Cl2N2/c1-2-9-12-7-3-5(10)6(11)4-8(7)13-9/h3-4H,2H2,1H3,(H,12,13) TUAVLJUMDKFUGC-UHFFFAOYSA-N 41789 5,6-bis(chloranyl)-2-ethyl-1H-benzimidazole::5,6-dichloro-2-ethyl-1H-benzimidazole::MLS000064722::SMR000077529::cid_972654 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41789&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 972654 252622510 ZINC00612976 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77928 COc1ccc(cc1)S(=O)(=O)N(C)CC(=O)Nc1ccccc1C(F)(F)F InChI=1S/C17H17F3N2O4S/c1-22(27(24,25)13-9-7-12(26-2)8-10-13)11-16(23)21-15-6-4-3-5-14(15)17(18,19)20/h3-10H,11H2,1-2H3,(H,21,23) SCASZLCSYABLPV-UHFFFAOYSA-N 41790 2-[(4-methoxyphenyl)sulfonyl-methyl-amino]-N-[2-(trifluoromethyl)phenyl]acetamide::2-[(4-methoxyphenyl)sulfonyl-methyl-amino]-N-[2-(trifluoromethyl)phenyl]ethanamide::2-[(4-methoxyphenyl)sulfonyl-methylamino]-N-[2-(trifluoromethyl)phenyl]acetamide::MLS000096640::N~2~-[(4-methoxyphenyl)sulfonyl]-N~2~-methyl-N~1~-[2-(trifluoromethyl)phenyl]glycinamide::SMR000073810::cid_1318352 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41790&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1318352 252622511 ZINC01146983 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77929 COC(=O)CNC(=O)C12CC3(C)CC(C)(CC(C)(C3)C1)C2 InChI=1S/C17H27NO3/c1-14-6-15(2)8-16(3,7-14)11-17(9-14,10-15)13(20)18-5-12(19)21-4/h5-11H2,1-4H3,(H,18,20) YMIFHWGGNONKNU-UHFFFAOYSA-N 41791 2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetic acid methyl ester::2-[[oxo-(3,5,7-trimethyl-1-adamantyl)methyl]amino]acetic acid methyl ester::MLS000099463::SMR000074065::cid_2944994::methyl 2-[(3,5,7-trimethyl-1-adamantyl)carbonylamino]ethanoate::methyl 2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetate::methyl N-[(3,5,7-trimethyl-1-adamantyl)carbonyl]glycinate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41791&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2944994 252622512 ZINC04197139 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77930 C=CCn1c2ccccc2c2nnc(SCc3ccc4nonc4c3)nc12 InChI=1S/C19H14N6OS/c1-2-9-25-16-6-4-3-5-13(16)17-18(25)20-19(22-21-17)27-11-12-7-8-14-15(10-12)24-26-23-14/h2-8,10H,1,9,11H2 CBDVEMJKSUSVCA-UHFFFAOYSA-N 41792 5-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanylmethyl]-2,1,3-benzoxadiazole::5-[[(5-allyl-[1,2,4]triazin[5,6-b]indol-3-yl)thio]methyl]benzofurazan::5-[[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl]-2,1,3-benzoxadiazole::5-allyl-3-[(2,1,3-benzoxadiazol-5-ylmethyl)thio]-5H-[1,2,4]triazino[5,6-b]indole::MLS000050812::SMR000078439::cid_2963029 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41792&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2963029 252622513 ZINC00719220 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77931 COc1cccc(OC)c1C(=O)N1CCN(CC1)c1ccccn1 InChI=1S/C18H21N3O3/c1-23-14-6-5-7-15(24-2)17(14)18(22)21-12-10-20(11-13-21)16-8-3-4-9-19-16/h3-9H,10-13H2,1-2H3 SFCMHKMQHYHCNL-UHFFFAOYSA-N 41793 (2,6-dimethoxyphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone::(2,6-dimethoxyphenyl)-[4-(2-pyridinyl)-1-piperazinyl]methanone::(2,6-dimethoxyphenyl)-[4-(2-pyridyl)piperazino]methanone::1-(2,6-dimethoxybenzoyl)-4-(2-pyridinyl)piperazine::MLS000064408::SMR000078044::cid_973595 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41793&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 973595 252622514 ZINC04272463 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77932 Brc1ccc(cc1)N1CC(=O)N(CC(=O)N2CCCc3ccccc23)C1=O InChI=1S/C20H18BrN3O3/c21-15-7-9-16(10-8-15)23-12-19(26)24(20(23)27)13-18(25)22-11-3-5-14-4-1-2-6-17(14)22/h1-2,4,6-10H,3,5,11-13H2 GWERRMPVBJOLKR-UHFFFAOYSA-N 41794 1-(4-bromophenyl)-3-[2-(3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]-2,4-imidazolidinedione::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-keto-ethyl]hydantoin::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxidanylidene-ethyl]imidazolidine-2,4-dione::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]imidazolidine-2,4-dione::MLS000051992::SMR000081238::cid_2228525 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41794&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2228525 252622515 ZINC02876136 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77933 COC(=O)c1cc(NC(=O)C2CCCO2)cc(c1)C(=O)OC InChI=1S/C15H17NO6/c1-20-14(18)9-6-10(15(19)21-2)8-11(7-9)16-13(17)12-4-3-5-22-12/h6-8,12H,3-5H2,1-2H3,(H,16,17) PFCZCPVSHGSOQJ-UHFFFAOYSA-N 41795 5-(tetrahydrofuran-2-carbonylamino)benzene-1,3-dicarboxylic acid dimethyl ester::5-[[oxo(2-oxolanyl)methyl]amino]benzene-1,3-dicarboxylic acid dimethyl ester::MLS000088767::SMR000071907::cid_2932403::dimethyl 5-(oxolan-2-ylcarbonylamino)benzene-1,3-dicarboxylate::dimethyl 5-(oxolane-2-carbonylamino)benzene-1,3-dicarboxylate::dimethyl 5-[(tetrahydro-2-furanylcarbonyl)amino]isophthalate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41795&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2932403 252622516 ZINC00475707 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77934 CCOCCCNC(=O)CCCOc1ccccc1 InChI=1S/C15H23NO3/c1-2-18-12-7-11-16-15(17)10-6-13-19-14-8-4-3-5-9-14/h3-5,8-9H,2,6-7,10-13H2,1H3,(H,16,17) OAJDPKICLPKFMF-UHFFFAOYSA-N 41796 MLS000088375::N-(3-ethoxypropyl)-4-phenoxy-butanamide::N-(3-ethoxypropyl)-4-phenoxy-butyramide::N-(3-ethoxypropyl)-4-phenoxybutanamide::SMR000071739::cid_2179064 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41796&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2179064 252622517 ZINC02818924 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77935 O=c1[nH]cc(COCc2ccccc2)c(=O)[nH]1 InChI=1S/C12H12N2O3/c15-11-10(6-13-12(16)14-11)8-17-7-9-4-2-1-3-5-9/h1-6H,7-8H2,(H2,13,14,15,16) QDNLNNAXVJQLJO-UHFFFAOYSA-N 41797 5-(benzoxymethyl)uracil::5-(phenylmethoxymethyl)-1H-pyrimidine-2,4-dione::5-[(benzyloxy)methyl]-2,4(1H,3H)-pyrimidinedione::MLS000061082::SMR000069595::cid_309850 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41797&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 309850 252622518 ZINC00051670 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77936 Cc1cc(C)n(n1)-c1nnc2SCC(=Nn12)c1ccccc1 InChI=1S/C15H14N6S/c1-10-8-11(2)20(18-10)14-16-17-15-21(14)19-13(9-22-15)12-6-4-3-5-7-12/h3-8H,9H2,1-2H3 KXZFAXRVIUAZFK-UHFFFAOYSA-N 41798 3-(3,5-dimethyl-1-pyrazolyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::3-(3,5-dimethylpyrazol-1-yl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::MLS000063441::SMR000072098::cid_887538 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41798&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 887538 252622519 ZINC00461052 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77937 CCn1ncc(CN2CCN(CC2)C(=O)Nc2ccccc2C(=O)OC)c1C InChI=1S/C20H27N5O3/c1-4-25-15(2)16(13-21-25)14-23-9-11-24(12-10-23)20(27)22-18-8-6-5-7-17(18)19(26)28-3/h5-8,13H,4,9-12,14H2,1-3H3,(H,22,27) DDAPFCDOCILUNS-UHFFFAOYSA-N 41799 2-[[4-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]piperazine-1-carbonyl]amino]benzoic acid methyl ester::2-[[[4-[(1-ethyl-5-methyl-4-pyrazolyl)methyl]-1-piperazinyl]-oxomethyl]amino]benzoic acid methyl ester::MLS000097106::SMR000076600::cid_2206454::methyl 2-[({4-[(1-ethyl-5-methyl-1H-pyrazol-4-yl)methyl]-1-piperazinyl}carbonyl)amino]benzoate::methyl 2-[[4-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]piperazin-1-yl]carbonylamino]benzoate::methyl 2-[[4-[(1-ethyl-5-methylpyrazol-4-yl)methyl]piperazine-1-carbonyl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41799&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2206454 252622520 ZINC22558024 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77938 CC1Cc2ccccc2N1C(=O)c1ccc2n(C)nnc2c1 InChI=1S/C17H16N4O/c1-11-9-12-5-3-4-6-15(12)21(11)17(22)13-7-8-16-14(10-13)18-19-20(16)2/h3-8,10-11H,9H2,1-2H3 LBTDPRQVAPEDGK-UHFFFAOYSA-N 41800 (1-methyl-5-benzotriazolyl)-(2-methyl-2,3-dihydroindol-1-yl)methanone::(1-methylbenzotriazol-5-yl)-(2-methyl-2,3-dihydroindol-1-yl)methanone::(1-methylbenzotriazol-5-yl)-(2-methylindolin-1-yl)methanone::1-methyl-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)carbonyl]-1H-1,2,3-benzotriazole::MLS000063757::SMR000075546::cid_2950653 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41800&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2950653 252622521 ZINC00619278 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77939 CCc1noc(C)c1C(=O)N1CCOCC1 InChI=1S/C11H16N2O3/c1-3-9-10(8(2)16-12-9)11(14)13-4-6-15-7-5-13/h3-7H2,1-2H3 XPRQQOUFQFNJLI-UHFFFAOYSA-N 41801 (3-ethyl-5-methyl-1,2-oxazol-4-yl)-morpholin-4-yl-methanone::(3-ethyl-5-methyl-1,2-oxazol-4-yl)-morpholin-4-ylmethanone::(3-ethyl-5-methyl-4-isoxazolyl)-(4-morpholinyl)methanone::(3-ethyl-5-methyl-isoxazol-4-yl)-morpholino-methanone::4-[(3-ethyl-5-methyl-4-isoxazolyl)carbonyl]morpholine::MLS000065678::SMR000080331::cid_1245299 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41801&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1245299 252622522 ZINC01053681 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77940 NC(=O)Cn1c(nc2ccccc12)S(=O)(=O)Cc1ccccc1 InChI=1S/C16H15N3O3S/c17-15(20)10-19-14-9-5-4-8-13(14)18-16(19)23(21,22)11-12-6-2-1-3-7-12/h1-9H,10-11H2,(H2,17,20) VJBVYGXBOSHOIA-UHFFFAOYSA-N 41802 2-(2-benzylsulfonylbenzimidazol-1-yl)acetamide::2-[2-(benzylsulfonyl)-1H-benzimidazol-1-yl]acetamide::2-[2-(phenylmethyl)sulfonyl-1-benzimidazolyl]acetamide::2-[2-(phenylmethyl)sulfonylbenzimidazol-1-yl]ethanamide::MLS000064097::SMR000075943::cid_713670 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41802&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 713670 252622523 ZINC00107798 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77941 CC(C)(C)NC(=O)CC(CC(O)=O)c1ccccc1 InChI=1S/C15H21NO3/c1-15(2,3)16-13(17)9-12(10-14(18)19)11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,17)(H,18,19) YXIBWSNBWFLHSC-UHFFFAOYSA-N 41803 5-(tert-butylamino)-5-keto-3-phenyl-valeric acid::5-(tert-butylamino)-5-oxidanylidene-3-phenyl-pentanoic acid::5-(tert-butylamino)-5-oxo-3-phenylpentanoic acid::MLS000120585::SMR000097437::cid_3580533 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41803&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3580533 252622524 ZINC03646794 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77942 COc1ccc(Nc2oc(nc2C#N)-c2ccccc2Cl)cc1 InChI=1S/C17H12ClN3O2/c1-22-12-8-6-11(7-9-12)20-17-15(10-19)21-16(23-17)13-4-2-3-5-14(13)18/h2-9,20H,1H3 RXBBQCAWCVEWFQ-UHFFFAOYSA-N 39564 2-(2-chlorophenyl)-5-(4-methoxyanilino)-1,3-oxazole-4-carbonitrile::2-(2-chlorophenyl)-5-(4-methoxyanilino)-4-oxazolecarbonitrile::2-(2-chlorophenyl)-5-(p-anisidino)oxazole-4-carbonitrile::2-(2-chlorophenyl)-5-[(4-methoxyphenyl)amino]-1,3-oxazole-4-carbonitrile::MLS000103052::SMR000018585::cid_946201 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39564&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 946201 252620455 ZINC00544706 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77943 CN(C)c1ccc(cc1)C(=O)Nc1nc2CCCCc2s1 InChI=1S/C16H19N3OS/c1-19(2)12-9-7-11(8-10-12)15(20)18-16-17-13-5-3-4-6-14(13)21-16/h7-10H,3-6H2,1-2H3,(H,17,18,20) ZVKWKVBRZGMCEC-UHFFFAOYSA-N 37501 4-(dimethylamino)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)benzamide::MLS000100704::SMR000017424::cid_746147 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37501&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 746147 252618472 ZINC00189361 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77944 OCC(CO)(CO)N=Cc1cc(Br)ccc1O InChI=1S/C11H14BrNO4/c12-9-1-2-10(17)8(3-9)4-13-11(5-14,6-15)7-16/h1-4,14-17H,5-7H2 VYXIAZMAMSTAGX-UHFFFAOYSA-N 41804 (6E)-4-bromanyl-6-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methylidene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[(2-hydroxy-1,1-dimethylol-ethyl)amino]methylene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]methylidene]-1-cyclohexa-2,4-dienone::(6E)-4-bromo-6-[[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]methylidene]cyclohexa-2,4-dien-1-one::MLS000106424::SMR000103391::cid_5406010 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41804&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5406010 252622525 ZINC13126620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77945 OC(=O)COc1ccc(Br)cc1CN=O InChI=1S/C9H8BrNO4/c10-7-1-2-8(15-5-9(12)13)6(3-7)4-11-14/h1-3H,4-5H2,(H,12,13) KWXZZLFHSHNEHC-UHFFFAOYSA-N 41805 2-[4-bromanyl-2-(hydroxyiminomethyl)phenoxy]ethanoic acid::2-[4-bromo-2-(hydroximinomethyl)phenoxy]acetic acid::2-[4-bromo-2-(hydroxyiminomethyl)phenoxy]acetic acid::MLS000113958::SMR000109848::cid_887160 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41805&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91896517 252622526 ZINC20166683 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77946 O=C(COc1ccccc1)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C18H20N2O5S/c21-18(14-25-16-4-2-1-3-5-16)19-15-6-8-17(9-7-15)26(22,23)20-10-12-24-13-11-20/h1-9H,10-14H2,(H,19,21) WBYAGEJSHNRQAE-UHFFFAOYSA-N 41806 MLS000108227::N-(4-morpholin-4-ylsulfonylphenyl)-2-phenoxy-ethanamide::N-(4-morpholin-4-ylsulfonylphenyl)-2-phenoxyacetamide::N-(4-morpholinosulfonylphenyl)-2-phenoxy-acetamide::N-[4-(4-morpholinylsulfonyl)phenyl]-2-phenoxyacetamide::SMR000104188::cid_1010129 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41806&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1010129 252622527 ZINC00670442 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77947 CC1CCCC(C1)NC1CCCCNC1=O InChI=1S/C13H24N2O/c1-10-5-4-6-11(9-10)15-12-7-2-3-8-14-13(12)16/h10-12,15H,2-9H2,1H3,(H,14,16) QXPOPAWVLRBGAF-UHFFFAOYSA-N 41807 3-[(3-methylcyclohexyl)amino]-2-azepanone::3-[(3-methylcyclohexyl)amino]azepan-2-one::MLS000106622::SMR000110999::cid_2846276 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41807&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2846276 252622528 ZINC04989210 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77948 CC1CN(CCC1=O)C1CC(C)(C)NC(C)(C)C1 InChI=1S/C15H28N2O/c1-11-10-17(7-6-13(11)18)12-8-14(2,3)16-15(4,5)9-12/h11-12,16H,6-10H2,1-5H3 SISQFEZLNOSCNG-UHFFFAOYSA-N 41808 3-methyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-4-piperidinone::3-methyl-1-(2,2,6,6-tetramethyl-4-piperidyl)-4-piperidone::3-methyl-1-(2,2,6,6-tetramethylpiperidin-4-yl)piperidin-4-one::MLS000110137::SMR000106069::cid_547348 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41808&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 547348 252622529 ZINC19798180 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77949 Cc1ccc(OCC(=O)Nc2ccc(cc2)N2CCOCC2)cc1 InChI=1S/C19H22N2O3/c1-15-2-8-18(9-3-15)24-14-19(22)20-16-4-6-17(7-5-16)21-10-12-23-13-11-21/h2-9H,10-14H2,1H3,(H,20,22) YXYYNLLGGPQOKU-UHFFFAOYSA-N 41809 2-(4-methylphenoxy)-N-(4-morpholin-4-ylphenyl)acetamide::2-(4-methylphenoxy)-N-(4-morpholin-4-ylphenyl)ethanamide::2-(4-methylphenoxy)-N-(4-morpholinophenyl)acetamide::2-(4-methylphenoxy)-N-[4-(4-morpholinyl)phenyl]acetamide::MLS000107479::SMR000111845::cid_682558 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41809&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 682558 252622530 ZINC00048261 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77950 OC(=O)C1CCCCC1C(=O)Nc1ccc2OCCOc2c1 InChI=1S/C16H19NO5/c18-15(11-3-1-2-4-12(11)16(19)20)17-10-5-6-13-14(9-10)22-8-7-21-13/h5-6,9,11-12H,1-4,7-8H2,(H,17,18)(H,19,20) LWYYYWNLCLHWQV-UHFFFAOYSA-N 41810 2-(2,3-dihydro-1,4-benzodioxin-6-ylcarbamoyl)cyclohexane-1-carboxylic acid::2-(2,3-dihydro-1,4-benzodioxin-6-ylcarbamoyl)cyclohexanecarboxylic acid::2-[(2,3-dihydro-1,4-benzodioxin-6-ylamino)-oxomethyl]-1-cyclohexanecarboxylic acid::MLS000107960::SMR000103924::cid_2862450 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41810&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2862450 252622531 ZINC00113642 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77951 CCC(C)c1ccc(NC(=O)C2CC2)cc1 InChI=1S/C14H19NO/c1-3-10(2)11-6-8-13(9-7-11)15-14(16)12-4-5-12/h6-10,12H,3-5H2,1-2H3,(H,15,16) FFJKVRCOUHEYOK-UHFFFAOYSA-N 41811 MLS000110184::N-(4-butan-2-ylphenyl)cyclopropanecarboxamide::N-(4-sec-butylphenyl)cyclopropanecarboxamide::SMR000106115::cid_2886949 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41811&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2886949 252622532 ZINC00442522 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77952 COc1ccc(cc1)N(C)C1=NS(=O)(=O)c2ccccc12 InChI=1S/C15H14N2O3S/c1-17(11-7-9-12(20-2)10-8-11)15-13-5-3-4-6-14(13)21(18,19)16-15/h3-10H,1-2H3 LLZMQRONMABMKW-UHFFFAOYSA-N 41812 (1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-(4-methoxy-phenyl)-methyl-amine::(1,1-diketo-1,2-benzothiazol-3-yl)-(4-methoxyphenyl)-methyl-amine::MLS000068583::N-(4-methoxyphenyl)-N-methyl-1,1-bis(oxidanylidene)-1,2-benzothiazol-3-amine::N-(4-methoxyphenyl)-N-methyl-1,1-dioxo-1,2-benzothiazol-3-amine::SMR000122953::cid_785727 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41812&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 785727 252622533 ZINC00282597 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77953 O=C(N1CCCCC1)c1ccc(cc1)-n1cnnn1 InChI=1S/C13H15N5O/c19-13(17-8-2-1-3-9-17)11-4-6-12(7-5-11)18-10-14-15-16-18/h4-7,10H,1-3,8-9H2 JNUBUUVSAUHVCX-UHFFFAOYSA-N 41813 1-piperidinyl-[4-(1-tetrazolyl)phenyl]methanone::MLS000121381::Piperidin-1-yl-(4-tetrazol-1-yl-phenyl)-methanone::SMR000118722::cid_817486::piperidin-1-yl-[4-(1,2,3,4-tetrazol-1-yl)phenyl]methanone::piperidin-1-yl-[4-(tetrazol-1-yl)phenyl]methanone::piperidino-[4-(tetrazol-1-yl)phenyl]methanone Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41813&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 817486 252622534 ZINC00331408 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77954 COc1cc(OC)cc(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C16H24N2O4/c1-20-14-10-13(11-15(12-14)21-2)16(19)17-4-3-5-18-6-8-22-9-7-18/h10-12H,3-9H2,1-2H3,(H,17,19) ZSVNZECOKWHYAB-UHFFFAOYSA-N 41814 3,5-Dimethoxy-N-(3-morpholin-4-yl-propyl)-benzamide::3,5-dimethoxy-N-(3-morpholin-4-ylpropyl)benzamide::3,5-dimethoxy-N-(3-morpholinopropyl)benzamide::3,5-dimethoxy-N-[3-(4-morpholinyl)propyl]benzamide::MLS000121576::SMR000118971::cid_2163734 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2163734 252622535 ZINC19760161 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77955 COc1cc(ccc1-n1cnnn1)S(=O)(=O)N1CCCCCC1 InChI=1S/C14H19N5O3S/c1-22-14-10-12(6-7-13(14)19-11-15-16-17-19)23(20,21)18-8-4-2-3-5-9-18/h6-7,10-11H,2-5,8-9H2,1H3 IANQVUKPSLMWSM-UHFFFAOYSA-N 41815 1-(3-Methoxy-4-tetrazol-1-yl-benzenesulfonyl)-azepane::1-[3-methoxy-4-(1,2,3,4-tetrazol-1-yl)phenyl]sulfonylazepane::1-[3-methoxy-4-(1-tetrazolyl)phenyl]sulfonylazepane::1-[3-methoxy-4-(tetrazol-1-yl)phenyl]sulfonylazepane::MLS000123482::SMR000124037::cid_858983 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41815&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 858983 252622536 ZINC00414808 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77956 Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(Cl)cc1 InChI=1S/C13H10ClN5O2/c1-18-12(20)9-11(16-13(18)21)19(2)17-10(15-9)7-3-5-8(14)6-4-7/h3-6H,1-2H3 UCEGDYDPOSBUTP-UHFFFAOYSA-N 40314 3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone::3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::MLS000523518::SMR000122591::US9073941, 603::cid_460749 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40314&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 460749 252621140 ZINC00267651 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77957 Cc1nn(C)c2nc(=O)n(C)c(=O)c2n1 InChI=1S/C8H9N5O2/c1-4-9-5-6(13(3)11-4)10-8(15)12(2)7(5)14/h1-3H3 CPXHNWKHOFNPDO-UHFFFAOYSA-N 34671 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone::MLS000528498::SMR000121073::US9073941, 611::cid_460747 Serine/threonine-protein kinase PLK1 Homo sapiens 1582.999945 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34671&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 460747 252617321 ZINC00490878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77958 Cc1[nH]n2c(nc(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccccc1 InChI=1S/C19H14N4O3/c1-12-18(14-5-3-2-4-6-14)19-20-16(11-17(24)22(19)21-12)13-7-9-15(10-8-13)23(25)26/h2-11,21H,1H3 XISRVALMPPEBHA-UHFFFAOYSA-N 37827 2-methyl-5-(4-nitrophenyl)-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one::5-{4-nitrophenyl}-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one::MLS000547439::SMR000113532::cid_1051569 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37827&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1051569 252618787 ZINC05439269 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77959 CCOC(=O)c1c(C)n(C)c2c1-c1cc(Br)ccc1C(=O)C2=O InChI=1S/C17H14BrNO4/c1-4-23-17(22)12-8(2)19(3)14-13(12)11-7-9(18)5-6-10(11)15(20)16(14)21/h5-7H,4H2,1-3H3 HKEXSVHEPUVAPQ-UHFFFAOYSA-N 40316 8-bromo-2,3-dimethyl-4,5-dioxo-1-benzo[e]indolecarboxylic acid ethyl ester::8-bromo-4,5-diketo-2,3-dimethyl-benz[e]indole-1-carboxylic acid ethyl ester::MLS000548053::SMR000114488::cid_1736381::ethyl 8-bromanyl-2,3-dimethyl-4,5-bis(oxidanylidene)benzo[e]indole-1-carboxylate::ethyl 8-bromo-2,3-dimethyl-4,5-dioxo-4,5-dihydro-3H-benzo[e]indole-1-carboxylate::ethyl 8-bromo-2,3-dimethyl-4,5-dioxobenzo[e]indole-1-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens 614.000022 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40316&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1736381 252621142 ZINC02075226 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77960 Cc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)c(C)c1 InChI=1S/C22H18N2O3S2/c1-14-9-10-18(15(2)12-14)23-20-13-19(16-6-3-4-7-17(16)22(20)25)24-29(26,27)21-8-5-11-28-21/h3-13,23H,1-2H3 LCGOLHKLWOZZSZ-UHFFFAOYSA-N 41816 (NE)-N-[3-(2,4-dimethylanilino)-4-keto-1-naphthylidene]thiophene-2-sulfonamide::(NE)-N-[3-(2,4-dimethylanilino)-4-oxo-1-naphthalenylidene]-2-thiophenesulfonamide::(NE)-N-[3-(2,4-dimethylanilino)-4-oxonaphthalen-1-ylidene]thiophene-2-sulfonamide::(NE)-N-[3-[(2,4-dimethylphenyl)amino]-4-oxidanylidene-naphthalen-1-ylidene]thiophene-2-sulfonamide::MLS000549894::N-(3-(2,4-dimethylanilino)-4-oxo-1(4H)-naphthalenylidene)-2-thiophenesulfonamide::SMR000113727::cid_9549688 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41816&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9549688 252622537 ZINC13111032 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77961 Oc1ccc2ccc3cccc[n+]3c2c1 InChI=1S/C13H9NO/c15-12-7-5-10-4-6-11-3-1-2-8-14(11)13(10)9-12/h1-9H/p+1 PGMYAFHGARCXKK-UHFFFAOYSA-O 41817 9-benzo[c]quinolizin-11-iumol;iodide::9-hydroxypyrido[1,2-a]quinolinium::MLS000548877::SMR000113700::benzo[c]quinolizin-11-ium-9-ol;iodide::cid_9549757 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41817&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 849585 252622538 ZINC00384120 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77962 Clc1cc(c(Cl)s1)-c1ccnc(SCC=C)n1 InChI=1S/C11H8Cl2N2S2/c1-2-5-16-11-14-4-3-8(15-11)7-6-9(12)17-10(7)13/h2-4,6H,1,5H2 QEMZGRCLCNTCII-UHFFFAOYSA-N 41818 2-(allylsulfanyl)-4-(2,5-dichloro-3-thienyl)pyrimidine::2-(allylthio)-4-(2,5-dichloro-3-thienyl)pyrimidine::4-(2,5-dichloro-3-thiophenyl)-2-(prop-2-enylthio)pyrimidine::4-(2,5-dichlorothiophen-3-yl)-2-prop-2-enylsulfanylpyrimidine::4-[2,5-bis(chloranyl)thiophen-3-yl]-2-prop-2-enylsulfanyl-pyrimidine::MLS000540566::SMR000125824::cid_3806023 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41818&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3806023 252622539 ZINC05382813 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77963 Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21 InChI=1S/C14H9NO2/c15-8-5-6-10-9-3-1-2-4-11(9)13(16)14(17)12(10)7-8/h1-7H,15H2 HENHQTJCDFNZOI-UHFFFAOYSA-N 50099737 2-Amino-phenanthrene-9,10-dione::CHEMBL417727::US9073941, 902::cid_254021 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099737&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 254021 103996562 CHEMBL417727 ZINC01713558 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77964 CC(C)Sc1nc(N2CCOCC2)c2CN(C)C(C)(C)Cc2c1C#N InChI=1S/C19H28N4OS/c1-13(2)25-18-15(11-20)14-10-19(3,4)22(5)12-16(14)17(21-18)23-6-8-24-9-7-23/h13H,6-10,12H2,1-5H3 VOFFAYCPMVCFGB-UHFFFAOYSA-N 41819 3-(isopropylthio)-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-yl-5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-(4-morpholinyl)-3-(propan-2-ylthio)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-morpholin-4-yl-3-propan-2-ylsulfanyl-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::MLS000552515::SMR000146030::cid_3790338 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41819&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3790338 252622540 ZINC13142403 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77965 Cc1cccc(C)c1NC1=NC(=S)N(c2ccccc2)C11CCOC(C)(C)C1 InChI=1S/C23H27N3OS/c1-16-9-8-10-17(2)19(16)24-20-23(13-14-27-22(3,4)15-23)26(21(28)25-20)18-11-6-5-7-12-18/h5-12H,13-15H2,1-4H3,(H,24,25,28) XOQWQVNJXRZWGS-UHFFFAOYSA-N 41820 4-(2,6-dimethylanilino)-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione::4-[(2,6-dimethylphenyl)amino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione::4-[(Z)-2,6-Dimethyl-phenylimino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diaza-spiro[4.5]decane-2-thione::MLS000552149::SMR000145863::cid_4005418 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41820&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4005418 252622541 ZINC17138319 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77966 O=C(CC1N(CCNC1=O)C(=S)Nc1ccccc1)Nc1ccc2OCCOc2c1 InChI=1S/C21H22N4O4S/c26-19(23-15-6-7-17-18(12-15)29-11-10-28-17)13-16-20(27)22-8-9-25(16)21(30)24-14-4-2-1-3-5-14/h1-7,12,16H,8-11,13H2,(H,22,27)(H,23,26)(H,24,30) BXQVEPADPAZKIN-UHFFFAOYSA-N 41821 2-[1-(anilinocarbonothioyl)-3-oxo-2-piperazinyl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::2-[1-[anilino(sulfanylidene)methyl]-3-oxo-2-piperazinyl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::MLS000538345::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-keto-1-(phenylthiocarbamoyl)piperazin-2-yl]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-oxidanylidene-1-(phenylcarbamothioyl)piperazin-2-yl]ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-oxo-1-(phenylcarbamothioyl)piperazin-2-yl]acetamide::SMR000144382::cid_2968933 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41821&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2968933 252622542 ZINC01079150 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77967 CS(=O)(=O)N1CCN(C\C=C\c2ccccc2)CC1 InChI=1S/C14H20N2O2S/c1-19(17,18)16-12-10-15(11-13-16)9-5-8-14-6-3-2-4-7-14/h2-8H,9-13H2,1H3/b8-5+ FOVOVNHELYBDGP-VMPITWQZSA-N 41822 1-(methylsulfonyl)-4-(3-phenyl-2-propen-1-yl)piperazine::1-[(E)-cinnamyl]-4-mesyl-piperazine::1-methylsulfonyl-4-[(E)-3-phenylprop-2-enyl]piperazine::MLS000530258::SMR000135235::cid_750930 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41822&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 750930 252622543 ZINC19536338 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77968 CCC(=O)Nc1ccccc1C(=O)NC1CCCCC1 InChI=1S/C16H22N2O2/c1-2-15(19)18-14-11-7-6-10-13(14)16(20)17-12-8-4-3-5-9-12/h6-7,10-12H,2-5,8-9H2,1H3,(H,17,20)(H,18,19) PWIYNYQZCMUDNH-UHFFFAOYSA-N 41823 MLS000538265::N-cyclohexyl-2-(1-oxopropylamino)benzamide::N-cyclohexyl-2-(propanoylamino)benzamide::N-cyclohexyl-2-(propionylamino)benzamide::N-cyclohexyl-2-propionamido-benzamide::SMR000144305::cid_974692 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41823&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 974692 252622544 ZINC00615774 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77969 Cc1ccc(CNC(=O)c2cc3c(n2C)c2ccccc2n(C)c3=O)cc1 InChI=1S/C22H21N3O2/c1-14-8-10-15(11-9-14)13-23-21(26)19-12-17-20(24(19)2)16-6-4-5-7-18(16)25(3)22(17)27/h4-12H,13H2,1-3H3,(H,23,26) GOCAPSRBFPHRLB-UHFFFAOYSA-N 41824 1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxidanylidene-pyrrolo[3,2-c]quinoline-2-carboxamide::1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxo-2-pyrrolo[3,2-c]quinolinecarboxamide::1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxopyrrolo[3,2-c]quinoline-2-carboxamide::4-keto-1,5-dimethyl-N-(4-methylbenzyl)pyrrolo[3,2-c]quinoline-2-carboxamide::MLS000522546::SMR000127813::cid_6622575 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41824&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6622575 252622545 ZINC04938861 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77970 COc1ccc2C(CC(O)=O)OC(=O)c2c1OC InChI=1S/C12H12O6/c1-16-7-4-3-6-8(5-9(13)14)18-12(15)10(6)11(7)17-2/h3-4,8H,5H2,1-2H3,(H,13,14) KAZZPXMHIZJNFS-UHFFFAOYSA-N 41825 (4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl)acetic acid::2-(3-keto-4,5-dimethoxy-phthalan-1-yl)acetic acid::2-(4,5-dimethoxy-3-oxidanylidene-1H-2-benzofuran-1-yl)ethanoic acid::2-(4,5-dimethoxy-3-oxo-1H-2-benzofuran-1-yl)acetic acid::2-(4,5-dimethoxy-3-oxo-1H-isobenzofuran-1-yl)acetic acid::MLS000530421::SMR000135399::cid_2863889 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41825&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2863889 252622546 ZINC00434141 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77971 COC(=O)c1ccccc1NC1=CC(=NS(=O)(=O)c2cccs2)c2ccccc2C1=O InChI=1S/C22H16N2O5S2/c1-29-22(26)16-9-4-5-10-17(16)23-19-13-18(14-7-2-3-8-15(14)21(19)25)24-31(27,28)20-11-6-12-30-20/h2-13,23H,1H3 SQTXZQUPJDPRBX-UHFFFAOYSA-N 41826 2-[[(4E)-1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]benzoic acid methyl ester::2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonylimino-2-naphthalenyl]amino]benzoic acid methyl ester::MLS000521465::SMR000131873::cid_9550941::methyl 2-[[(4E)-1-oxidanylidene-4-thiophen-2-ylsulfonylimino-naphthalen-2-yl]amino]benzoate::methyl 2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonyliminonaphthalen-2-yl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9550941 252622547 ZINC57608287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77972 O=C(Nc1nc2ccccc2s1)c1cc2COc3ccccc3-c2s1 InChI=1S/C19H12N2O2S2/c22-18(21-19-20-13-6-2-4-8-15(13)25-19)16-9-11-10-23-14-7-3-1-5-12(14)17(11)24-16/h1-9H,10H2,(H,20,21,22) YMEYVTRNCWQUKW-UHFFFAOYSA-N 40208 MLS000522634::N-(1,3-benzothiazol-2-yl)-4H-thieno[3,2-c][1]benzopyran-2-carboxamide::N-(1,3-benzothiazol-2-yl)-4H-thieno[3,2-c]chromene-2-carboxamide::SMR000127901::cid_9550946 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40208&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9550946 252621036 ZINC05050072 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77973 Cc1nc2cccc(C)n2c(=O)c1Cl InChI=1S/C10H9ClN2O/c1-6-4-3-5-8-12-7(2)9(11)10(14)13(6)8/h3-5H,1-2H3 CAMDPFYIYQWBHS-UHFFFAOYSA-N 41827 3-chloranyl-2,6-dimethyl-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethyl-4-pyrido[1,2-a]pyrimidinone::3-chloro-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethyl-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethylpyrido[1,2-a]pyrimidin-4-one::MLS000539503::SMR000125161::cid_3255478 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41827&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3255478 252622548 ZINC03029426 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77974 Cn1cc(SCC(=O)Nc2ccc3OCCOc3c2)c2ccccc12 InChI=1S/C19H18N2O3S/c1-21-11-18(14-4-2-3-5-15(14)21)25-12-19(22)20-13-6-7-16-17(10-13)24-9-8-23-16/h2-7,10-11H,8-9,12H2,1H3,(H,20,22) KEWYZVKHGDWOBD-UHFFFAOYSA-N 41828 MLS000529783::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(1-methylindol-3-yl)sulfanyl-ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(1-methylindol-3-yl)sulfanylacetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(1-methyl-3-indolyl)thio]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(1-methylindol-3-yl)thio]acetamide::SMR000126809::cid_4663634 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41828&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4663634 252622549 ZINC03581738 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77975 Cn1c(nc2ccccc12)-c1cc2ccc(OC(=O)C(C)(C)C)cc2oc1=O InChI=1S/C22H20N2O4/c1-22(2,3)21(26)27-14-10-9-13-11-15(20(25)28-18(13)12-14)19-23-16-7-5-6-8-17(16)24(19)4/h5-12H,1-4H3 SLVVLPLLOLFSNR-UHFFFAOYSA-N 41829 2,2-Dimethyl-propionic acid 3-(1-methyl-1H-benzoimidazol-2-yl)-2-oxo-2H-chromen-7-yl ester::2,2-dimethylpropanoic acid [3-(1-methyl-2-benzimidazolyl)-2-oxo-1-benzopyran-7-yl] ester::2,2-dimethylpropionic acid [2-keto-3-(1-methylbenzimidazol-2-yl)chromen-7-yl] ester::MLS000556974::SMR000148091::[3-(1-methylbenzimidazol-2-yl)-2-oxidanylidene-chromen-7-yl] 2,2-dimethylpropanoate::[3-(1-methylbenzimidazol-2-yl)-2-oxochromen-7-yl] 2,2-dimethylpropanoate::cid_1522831 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41829&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1522831 252622550 ZINC01447934 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77976 CCCc1nc2sc3CCCCc3c2c(=O)n1NC(=O)CCC(O)=O InChI=1S/C17H21N3O4S/c1-2-5-12-18-16-15(10-6-3-4-7-11(10)25-16)17(24)20(12)19-13(21)8-9-14(22)23/h2-9H2,1H3,(H,19,21)(H,22,23) UFZNWSZCQFKQIW-UHFFFAOYSA-N 41830 4-keto-4-[(4-keto-2-propyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-3-yl)amino]butyric acid::4-oxidanylidene-4-[(4-oxidanylidene-2-propyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-3-yl)amino]butanoic acid::4-oxo-4-[(4-oxo-2-propyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-3-yl)amino]butanoic acid::MLS000550849::N-(4-Oxo-2-propyl-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-3-yl)-succinamic acid::SMR000144977::cid_1861941 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41830&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1861941 252622551 ZINC02230233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77977 Cc1oc-2c(c1C(=O)c1ccccc1)C(=O)C(=O)c1ccccc-21 InChI=1S/C20H12O4/c1-11-15(17(21)12-7-3-2-4-8-12)16-19(23)18(22)13-9-5-6-10-14(13)20(16)24-11/h2-10H,1H3 XEMFSKXFWNHKIS-UHFFFAOYSA-N 34691 2-methyl-3-(phenylcarbonyl)benzo[g][1]benzofuran-4,5-dione::3-Benzoyl-2-methyl-naphtho[1,2-b]furan-4,5-dione::3-benzoyl-2-methyl-benzo[g]benzofuran-4,5-quinone::3-benzoyl-2-methylbenzo[g][1]benzofuran-4,5-dione::3-benzoyl-2-methylbenzo[g]benzofuran-4,5-dione::MLS000554105::SMR000146422::cid_3816369 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34691&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3816369 252617341 ZINC04785917 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77978 CC(=O)N(N=C1Sc2ccccc2C1=O)c1cccc(C)c1 InChI=1S/C17H14N2O2S/c1-11-6-5-7-13(10-11)19(12(2)20)18-17-16(21)14-8-3-4-9-15(14)22-17/h3-10H,1-2H3 ZTBUBWXLRCXSOT-UHFFFAOYSA-N 41831 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-m-tolyl-hydrazide::MLS000552764::N-(3-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide::N-(3-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide::SMR000146279::cid_759945 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41831&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401878 252622552 ZINC12559942 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77979 CC(=O)N(N=C1Sc2ccccc2C1=O)c1ccccc1C InChI=1S/C17H14N2O2S/c1-11-7-3-5-9-14(11)19(12(2)20)18-17-16(21)13-8-4-6-10-15(13)22-17/h3-10H,1-2H3 OBPOWEVMSNKZCM-UHFFFAOYSA-N 41832 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-o-tolyl-hydrazide::MLS000552762::N-(2-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide::N-(2-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::SMR000146277::cid_759936 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41832&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401874 252622553 ZINC12561994 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77980 CC(=O)N(N=C1Sc2ccccc2C1=O)c1ccccc1 InChI=1S/C16H12N2O2S/c1-11(19)18(12-7-3-2-4-8-12)17-16-15(20)13-9-5-6-10-14(13)21-16/h2-10H,1H3 KYSFXQOZNRWVLN-UHFFFAOYSA-N 41833 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-phenyl-hydrazide::MLS000552761::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-phenyl-acetamide::N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]-N-phenyl-ethanamide::N-[(3-oxo-1-benzothiophen-2-ylidene)amino]-N-phenylacetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-phenyl-acetamide::SMR000146276::cid_759934 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41833&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401873 252622554 ZINC12561922 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77981 CCOc1ccccc1N1CCN(CC1)C1=C(NS(=O)(=O)c2cccs2)C(=O)c2ccccc2C1=O InChI=1S/C26H25N3O5S2/c1-2-34-21-11-6-5-10-20(21)28-13-15-29(16-14-28)24-23(27-36(32,33)22-12-7-17-35-22)25(30)18-8-3-4-9-19(18)26(24)31/h3-12,17,27H,2,13-16H2,1H3 IWDXUFGXDULHDB-UHFFFAOYSA-N 41834 MLS000551587::N-[1,4-diketo-3-(4-o-phenetylpiperazino)-2-naphthyl]thiophene-2-sulfonamide::N-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]-1,4-dioxo-2-naphthalenyl]-2-thiophenesulfonamide::N-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,4-bis(oxidanylidene)naphthalen-2-yl]thiophene-2-sulfonamide::N-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,4-dioxonaphthalen-2-yl]thiophene-2-sulfonamide::SMR000145512::Thiophene-2-sulfonic acid {3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-1,4-dioxo-1,4-dihydro-naphthalen-2-yl}-amide::cid_1423408 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41834&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1423408 252622555 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77982 CC(C)Nc1nnc(SCC(=O)c2c(N)n(Cc3ccccc3)c(=O)n(C)c2=O)s1 InChI=1S/C19H22N6O3S2/c1-11(2)21-17-22-23-18(30-17)29-10-13(26)14-15(20)25(19(28)24(3)16(14)27)9-12-7-5-4-6-8-12/h4-8,11H,9-10,20H2,1-3H3,(H,21,22) OGOGCOROTDLCTB-UHFFFAOYSA-N 41835 6-amino-1-benzyl-3-methyl-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione::6-amino-1-benzyl-5-[2-[[5-(isopropylamino)-1,3,4-thiadiazol-2-yl]thio]acetyl]-3-methyl-pyrimidine-2,4-quinone::6-amino-3-methyl-5-[1-oxo-2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]thio]ethyl]-1-(phenylmethyl)pyrimidine-2,4-dione::6-azanyl-3-methyl-1-(phenylmethyl)-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanoyl]pyrimidine-2,4-dione::MLS000568091::SMR000154422::cid_2501656 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41835&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2501656 252622556 ZINC03383369 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77983 O=C1C(=O)c2ccccc2-c2ccccc12 InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H YYVYAPXYZVYDHN-UHFFFAOYSA-N 22857 1,2-Dione-Based Compound, 14::9,10-dihydrophenanthrene-9,10-dione::CHEMBL51931::Phenanthrene-9,10 dione::cid_6763 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22857&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6763 49846671 37454 CHEMBL51931 C03243 ZINC01529614 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77984 Cc1nn(CCc2n[nH]c(=S)n2-c2cccc(C)c2)c(C)c1[N+]([O-])=O InChI=1S/C16H18N6O2S/c1-10-5-4-6-13(9-10)21-14(17-18-16(21)25)7-8-20-12(3)15(22(23)24)11(2)19-20/h4-6,9H,7-8H2,1-3H3,(H,18,25) VRRDUIBPADYHAW-UHFFFAOYSA-N 41836 3-(2-{4-nitro-3,5-dimethyl-1H-pyrazol-1-yl}ethyl)-4-(3-methylphenyl)-5-sulfanyl-4H-1,2,4-triazole::3-[2-(3,5-dimethyl-4-nitro-1-pyrazolyl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)ethyl]-4-(m-tolyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitropyrazol-1-yl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::MLS000538660::SMR000160121::cid_998946 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41836&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 998946 252622557 ZINC05427265 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77985 Cc1cccc2[nH]c3c(ncnc3c12)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C20H19N5O2/c1-13-4-2-5-14-16(13)17-18(23-14)19(22-12-21-17)24-7-9-25(10-8-24)20(26)15-6-3-11-27-15/h2-6,11-12,23H,7-10H2,1H3 IRQKMWLRGOXGDP-UHFFFAOYSA-N 41837 2-furanyl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)-1-piperazinyl]methanone::2-furyl-[4-(9-methyl-5H-pyrimid[5,4-b]indol-4-yl)piperazino]methanone::Furan-2-yl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)-piperazin-1-yl]-methanone::MLS000558194::SMR000148910::cid_1979644::furan-2-yl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)piperazin-1-yl]methanone Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1979644 252622558 ZINC02368389 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77986 Nc1cc(nn1S(=O)(=O)c1cccc2nsnc12)-c1ccc(Br)cc1 InChI=1S/C15H10BrN5O2S2/c16-10-6-4-9(5-7-10)12-8-14(17)21(18-12)25(22,23)13-3-1-2-11-15(13)20-24-19-11/h1-8H,17H2 WSZWPRMGVHHVON-UHFFFAOYSA-N 41838 2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)-3-pyrazolamine::2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)pyrazol-3-amine::MLS000523036::SMR000128302::[5-(4-bromophenyl)-2-piazthiol-4-ylsulfonyl-pyrazol-3-yl]amine::cid_11957251 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11957251 252622559 ZINC08680561 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77987 NC(=O)C1CCN(CC1)C1=C(Cl)C(=O)c2ccccc2C1=O InChI=1S/C16H15ClN2O3/c17-12-13(19-7-5-9(6-8-19)16(18)22)15(21)11-4-2-1-3-10(11)14(12)20/h1-4,9H,5-8H2,(H2,18,22) JBMKSILOCSVHGX-UHFFFAOYSA-N 41839 1-(3-chloro-1,4-diketo-2-naphthyl)isonipecotamide::1-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-4-piperidinecarboxamide::1-(3-chloro-1,4-dioxo-2-naphthalenyl)-4-piperidinecarboxamide::1-(3-chloro-1,4-dioxonaphthalen-2-yl)piperidine-4-carboxamide::1-[3-chloranyl-1,4-bis(oxidanylidene)naphthalen-2-yl]piperidine-4-carboxamide::MLS000547001::SMR000180199::cid_1481943 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41839&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1481943 252622560 ZINC01395148 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77988 Clc1cccc(Cl)c1Cn1cccc(NC(=O)c2c(Cl)cccc2Cl)c1=O InChI=1S/C19H12Cl4N2O2/c20-12-4-1-5-13(21)11(12)10-25-9-3-8-16(19(25)27)24-18(26)17-14(22)6-2-7-15(17)23/h1-9H,10H2,(H,24,26) YODRLVBIQYILMX-UHFFFAOYSA-N 41840 2,6-dichloro-N-[1-(2,6-dichlorobenzyl)-2-keto-3-pyridyl]benzamide::2,6-dichloro-N-[1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydro-3-pyridinyl]benzenecarboxamide::2,6-dichloro-N-[1-[(2,6-dichlorophenyl)methyl]-2-oxo-3-pyridinyl]benzamide::2,6-dichloro-N-[1-[(2,6-dichlorophenyl)methyl]-2-oxopyridin-3-yl]benzamide::MLS000543295::N-[1-[[2,6-bis(chloranyl)phenyl]methyl]-2-oxidanylidene-pyridin-3-yl]-2,6-bis(chloranyl)benzamide::SMR000169264::cid_3679261 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41840&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3679261 252622561 ZINC03041620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77989 Nc1cc2nsnc2cc1Br InChI=1S/C6H4BrN3S/c7-3-1-5-6(2-4(3)8)10-11-9-5/h1-2H,8H2 CDEJXRZSAIZTRF-UHFFFAOYSA-N 40726 (6-bromopiazthiol-5-yl)amine::5-bromanyl-2,1,3-benzothiadiazol-6-amine::5-bromo-2,1,3-benzothiadiazol-6-amine::6-Bromo-benzo[1,2,5]thiadiazol-5-ylamine::MLS000556153::SMR000174162::cid_3096032 Serine/threonine-protein kinase PLK1 Homo sapiens 13279.00028 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40726&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3096032 252621543 ZINC02566853 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77990 Cc1ccc(cc1)C(=O)c1c[nH]c(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C20H25N3O3/c1-15-3-5-16(6-4-15)19(24)17-13-18(22-14-17)20(25)21-7-2-8-23-9-11-26-12-10-23/h3-6,13-14,22H,2,7-12H2,1H3,(H,21,25) XQVAGUMIWDNJTA-UHFFFAOYSA-N 41841 4-(4-methylbenzoyl)-N-(3-morpholin-4-ylpropyl)-1H-pyrrole-2-carboxamide::4-(4-methylbenzoyl)-N-(3-morpholinopropyl)-1H-pyrrole-2-carboxamide::4-(4-methylphenyl)carbonyl-N-(3-morpholin-4-ylpropyl)-1H-pyrrole-2-carboxamide::4-[(4-methylphenyl)-oxomethyl]-N-[3-(4-morpholinyl)propyl]-1H-pyrrole-2-carboxamide::MLS000546923::N-(3-morpholinopropyl)-4-p-toluoyl-1H-pyrrole-2-carboxamide::SMR000180121::cid_3813794 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41841&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3813794 252622562 ZINC20405048 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77991 Cc1ccccc1Oc1ncnc2oc(cc12)-c1ccccc1 InChI=1S/C19H14N2O2/c1-13-7-5-6-10-16(13)22-18-15-11-17(14-8-3-2-4-9-14)23-19(15)21-12-20-18/h2-12H,1H3 ATKPLDDGMIKJMB-UHFFFAOYSA-N 41842 4-(2-methylphenoxy)-6-phenyl-furo[2,3-d]pyrimidine::4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidine::MLS000327159::SMR000179731::cid_3825639 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41842&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3825639 252622563 ZINC06218639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77992 OC1(N2CCCCC2)C(=O)Nc2ccc(cc12)[N+]([O-])=O InChI=1S/C13H15N3O4/c17-12-13(18,15-6-2-1-3-7-15)10-8-9(16(19)20)4-5-11(10)14-12/h4-5,8,18H,1-3,6-7H2,(H,14,17) YNAYNLVTESDOLF-UHFFFAOYSA-N 41843 3-hydroxy-5-nitro-3-(1-piperidinyl)-1,3-dihydro-2H-indol-2-one::3-hydroxy-5-nitro-3-(1-piperidinyl)-1H-indol-2-one::3-hydroxy-5-nitro-3-piperidin-1-yl-1H-indol-2-one::3-hydroxy-5-nitro-3-piperidino-oxindole::5-nitro-3-oxidanyl-3-piperidin-1-yl-1H-indol-2-one::MLS000579145::SMR000186733::cid_2859373 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41843&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2859373 252622564 ZINC04155872 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77993 CCN1C(=O)\C(=C\c2nc3ccccc3c(=O)n2-c2ccccc2)c2ccccc12 InChI=1S/C25H19N3O2/c1-2-27-22-15-9-7-12-18(22)20(24(27)29)16-23-26-21-14-8-6-13-19(21)25(30)28(23)17-10-4-3-5-11-17/h3-16H,2H2,1H3/b20-16+ YTNXBDRGDUEWNI-CAPFRKAQSA-N 41844 2-[(1-ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-phenyl-4(3H)-quinazolinone::2-[(E)-(1-ethyl-2-keto-indolin-3-ylidene)methyl]-3-phenyl-quinazolin-4-one::2-[(E)-(1-ethyl-2-oxidanylidene-indol-3-ylidene)methyl]-3-phenyl-quinazolin-4-one::2-[(E)-(1-ethyl-2-oxo-3-indolylidene)methyl]-3-phenyl-4-quinazolinone::2-[(E)-(1-ethyl-2-oxoindol-3-ylidene)methyl]-3-phenylquinazolin-4-one::MLS000570466::SMR000186892::cid_5336431 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41844&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5336431 252622565 ZINC32609533 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77994 [O-][N+](=O)c1cccc(c1)C(=O)NC(NC(=S)Nc1ccc(Cl)cc1Cl)C(Cl)(Cl)Cl InChI=1S/C16H11Cl5N4O3S/c17-9-4-5-12(11(18)7-9)22-15(29)24-14(16(19,20)21)23-13(26)8-2-1-3-10(6-8)25(27)28/h1-7,14H,(H,23,26)(H2,22,24,29) VAKBSJSQKQOLBN-UHFFFAOYSA-N 41845 3-nitro-N-[2,2,2-trichloro-1-({[(2,4-dichlorophenyl)amino]carbonothioyl}amino)ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[(2,4-dichlorophenyl)carbamothioylamino]ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[(2,4-dichlorophenyl)thiocarbamoylamino]ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[[(2,4-dichloroanilino)-sulfanylidenemethyl]amino]ethyl]benzamide::3-nitro-N-[2,2,2-tris(chloranyl)-1-[(2,4-dichlorophenyl)carbamothioylamino]ethyl]benzamide::MLS000573675::SMR000184524::cid_2830011 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41845&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2830011 252622566 ZINC17320775 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77995 [O-][N+](=O)c1ccc(cc1NCC1CCCO1)N1CCNCC1 InChI=1S/C15H22N4O3/c20-19(21)15-4-3-12(18-7-5-16-6-8-18)10-14(15)17-11-13-2-1-9-22-13/h3-4,10,13,16-17H,1-2,5-9,11H2 NBQUAKXLTFLOAI-UHFFFAOYSA-N 41846 (2-nitro-5-piperazino-phenyl)-(tetrahydrofurfuryl)amine::2-nitro-5-(1-piperazinyl)-N-(tetrahydro-2-furanylmethyl)aniline::2-nitro-N-(2-oxolanylmethyl)-5-(1-piperazinyl)aniline::2-nitro-N-(oxolan-2-ylmethyl)-5-piperazin-1-yl-aniline::2-nitro-N-(oxolan-2-ylmethyl)-5-piperazin-1-ylaniline::MLS000576313::SMR000197953::cid_2933906 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41846&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2933906 252622567 ZINC04140715 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77996 [O-][N+](=O)c1ccc(\C=C(\NC(=O)c2ccccc2)C(=O)NCCc2ccccc2)cc1 InChI=1S/C24H21N3O4/c28-23(20-9-5-2-6-10-20)26-22(17-19-11-13-21(14-12-19)27(30)31)24(29)25-16-15-18-7-3-1-4-8-18/h1-14,17H,15-16H2,(H,25,29)(H,26,28)/b22-17+ MIWCELHLXXHHJL-OQKWZONESA-N 41847 MLS000575866::N-(2-(4-nitrophenyl)-1-{[(2-phenylethyl)amino]carbonyl}vinyl)benzamide::N-[(E)-1-(4-nitrophenyl)-3-oxidanylidene-3-(2-phenylethylamino)prop-1-en-2-yl]benzamide::N-[(E)-1-(4-nitrophenyl)-3-oxo-3-(2-phenylethylamino)prop-1-en-2-yl]benzamide::N-[(E)-2-(4-nitrophenyl)-1-(phenethylcarbamoyl)vinyl]benzamide::SMR000196901::cid_5735412 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2Z036KJ aid876 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41847&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5735412 252622568 ZINC04844883 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77997 Fc1ccc(Cn2nnnc2CN2CCN(CC2)C2CCCC2)cc1 InChI=1S/C18H25FN6/c19-16-7-5-15(6-8-16)13-25-18(20-21-22-25)14-23-9-11-24(12-10-23)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 NUVIKTFIUDCSBH-UHFFFAOYSA-N 41747 1-Cyclopentyl-4-[1-(4-fluoro-benzyl)-1H-tetrazol-5-ylmethyl]-piperazine::1-cyclopentyl-4-[[1-(4-fluorobenzyl)tetrazol-5-yl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-1,2,3,4-tetrazol-5-yl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-5-tetrazolyl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]tetrazol-5-yl]methyl]piperazine::MLS000073054::SMR000004983::cid_644709 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41747&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 644709 252622468 ZINC22583409 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77998 COc1ccc2c(C)n[nH]c3cccc1c23 InChI=1S/C13H12N2O/c1-8-9-6-7-12(16-2)10-4-3-5-11(13(9)10)15-14-8/h3-7,15H,1-2H3 MXCNJRIUQVTTPS-UHFFFAOYSA-N 31997 6-Methoxy-3-methyl-1H-benzo[de]cinnoline::MLS000027089::SMR000010302::cid_644992 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31997&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 644992 242052843 ZINC04008434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 77999 CCC(=O)Nc1ccc(cc1)-c1nnc(SCC(=O)Nc2nccs2)n1C InChI=1S/C17H18N6O2S2/c1-3-13(24)19-12-6-4-11(5-7-12)15-21-22-17(23(15)2)27-10-14(25)20-16-18-8-9-26-16/h4-9H,3,10H2,1-2H3,(H,19,24)(H,18,20,25) CNOUHVBUCKBSLD-UHFFFAOYSA-N 41748 MLS000076456::N-[4-[4-methyl-5-[2-oxidanylidene-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[4-methyl-5-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[4-methyl-5-[[2-oxo-2-(2-thiazolylamino)ethyl]thio]-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[5-[[2-keto-2-(thiazol-2-ylamino)ethyl]thio]-4-methyl-1,2,4-triazol-3-yl]phenyl]propionamide::N-{4-[4-Methyl-5-(thiazol-2-ylcarbamoylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-phenyl}-propionamide::SMR000015120::cid_646718 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41748&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 646718 252622469 ZINC04510460 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78000 COc1ccccc1C1SCCN1S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C17H16F3NO3S2/c1-24-15-8-3-2-7-14(15)16-21(9-10-25-16)26(22,23)13-6-4-5-12(11-13)17(18,19)20/h2-8,11,16H,9-10H2,1H3 IANULKJFHGLGOX-UHFFFAOYSA-N 41749 2-(2-Methoxy-phenyl)-3-(3-trifluoromethyl-benzenesulfonyl)-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonyl-1,3-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonyl-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonylthiazolidine::MLS000030697::SMR000011601::cid_646735 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41749&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 646735 252622470 ZINC00887292 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78001 Clc1ccc(CC(=O)NCCN2CCCC2)cc1 InChI=1S/C14H19ClN2O/c15-13-5-3-12(4-6-13)11-14(18)16-7-10-17-8-1-2-9-17/h3-6H,1-2,7-11H2,(H,16,18) FCDXYGHRQACESV-UHFFFAOYSA-N 41750 2-(4-Chloro-phenyl)-N-(2-pyrrolidin-1-yl-ethyl)-acetamide::2-(4-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide;hydrochloride::2-(4-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)ethanamide;hydrochloride::2-(4-chlorophenyl)-N-(2-pyrrolidinoethyl)acetamide;hydrochloride::2-(4-chlorophenyl)-N-[2-(1-pyrrolidinyl)ethyl]acetamide;hydrochloride::MLS000075628::SMR000013881::cid_6603083 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41750&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 647301 252622471 ZINC02843177 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78002 CNC(=O)CC(C(O)=O)c1ccc(OCC(C)C)cc1 InChI=1S/C15H21NO4/c1-10(2)9-20-12-6-4-11(5-7-12)13(15(18)19)8-14(17)16-3/h4-7,10,13H,8-9H2,1-3H3,(H,16,17)(H,18,19) XQESYXHSGQLCNC-UHFFFAOYSA-N 41751 2-(4-Isobutoxy-phenyl)-N-methyl-succinamic acid::2-(4-isobutoxyphenyl)-4-keto-4-(methylamino)butyric acid::4-(methylamino)-2-[4-(2-methylpropoxy)phenyl]-4-oxidanylidene-butanoic acid::4-(methylamino)-2-[4-(2-methylpropoxy)phenyl]-4-oxobutanoic acid::MLS000068652::SMR000008612::cid_647848 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41751&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 647848 252622472 ZINC04411521 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78003 COc1ccc(cc1S(=O)(=O)Nc1ccc(Cl)cn1)C(C)C InChI=1S/C15H17ClN2O3S/c1-10(2)11-4-6-13(21-3)14(8-11)22(19,20)18-15-7-5-12(16)9-17-15/h4-10H,1-3H3,(H,17,18) XNYRYSBNCKGQLI-UHFFFAOYSA-N 41752 MLS000071127::N-(5-Chloro-pyridin-2-yl)-5-isopropyl-2-methoxy-benzenesulfonamide::N-(5-chloranylpyridin-2-yl)-2-methoxy-5-propan-2-yl-benzenesulfonamide::N-(5-chloro-2-pyridinyl)-2-methoxy-5-propan-2-ylbenzenesulfonamide::N-(5-chloro-2-pyridyl)-5-isopropyl-2-methoxy-benzenesulfonamide::N-(5-chloropyridin-2-yl)-2-methoxy-5-propan-2-ylbenzenesulfonamide::SMR000015187::cid_648225 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41752&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 648225 252622473 ZINC00384700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78004 Cc1ccc(NC(=O)C2CC=CCC2C(=O)N2CCCCC2)cc1 InChI=1S/C20H26N2O2/c1-15-9-11-16(12-10-15)21-19(23)17-7-3-4-8-18(17)20(24)22-13-5-2-6-14-22/h3-4,9-12,17-18H,2,5-8,13-14H2,1H3,(H,21,23) XWRKSKOBCZOXJA-UHFFFAOYSA-N 41753 6-(Piperidine-1-carbonyl)-cyclohex-3-enecarboxylic acid p-tolylamide::6-(piperidine-1-carbonyl)-N-(p-tolyl)cyclohex-3-ene-1-carboxamide::MLS000071126::N-(4-methylphenyl)-6-(piperidine-1-carbonyl)cyclohex-3-ene-1-carboxamide::N-(4-methylphenyl)-6-[oxo(1-piperidinyl)methyl]-1-cyclohex-3-enecarboxamide::N-(4-methylphenyl)-6-piperidin-1-ylcarbonyl-cyclohex-3-ene-1-carboxamide::SMR000010710::cid_648286 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41753&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 648286 252622474 ZINC00054230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78005 O=C1C(Nc2ccccc12)=C1C(=O)c2ccccc2C1=O InChI=1S/C17H9NO3/c19-15-9-5-1-2-6-10(9)16(20)13(15)14-17(21)11-7-3-4-8-12(11)18-14/h1-8,18H XXSJHAICOWNQBL-UHFFFAOYSA-N 32004 2-(3-Oxo-1,3-dihydro-indol-2-ylidene)-indan-1,3-dione::2-(3-ketoindolin-2-ylidene)indane-1,3-quinone::2-(3-oxidanylidene-1H-indol-2-ylidene)indene-1,3-dione::2-(3-oxo-1H-indol-2-ylidene)indene-1,3-dione::MLS000071738::SMR000010447::cid_649556 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32004&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 649556 252615466 ZINC06529695 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78006 COc1ccc(Cn2c3ccccc3sc2=O)cc1 InChI=1S/C15H13NO2S/c1-18-12-8-6-11(7-9-12)10-16-13-4-2-3-5-14(13)19-15(16)17/h2-9H,10H2,1H3 MHFZFKZXERZAKK-UHFFFAOYSA-N 41754 3-(4-Methoxy-benzyl)-3H-benzothiazol-2-one::3-[(4-methoxyphenyl)methyl]-1,3-benzothiazol-2-one::3-p-anisyl-1,3-benzothiazol-2-one::MLS000035042::SMR000015012::cid_649921 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41754&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 649921 252622475 ZINC00814287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78007 Cn1c2cccc3C(=O)c4ccccc4-c(c(NCCO)c1=O)c23 InChI=1S/C19H16N2O3/c1-21-14-8-4-7-13-15(14)16(17(19(21)24)20-9-10-22)11-5-2-3-6-12(11)18(13)23/h2-8,20,22H,9-10H2,1H3 JHRNUMVGSNJFOB-UHFFFAOYSA-N 32006 1-(2-Hydroxy-ethylamino)-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione::MLS000076121::SMR000013433::cid_650462 Serine/threonine-protein kinase PLK1 Homo sapiens 1810.99999 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32006&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 650462 242052845 ZINC18141610 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78008 Cc1ccc2cc(C(N3CCN(CC3)c3ccccc3)c3nnnn3C3CCCC3)c(=O)[nH]c2c1 InChI=1S/C27H31N7O/c1-19-11-12-20-18-23(27(35)28-24(20)17-19)25(26-29-30-31-34(26)22-9-5-6-10-22)33-15-13-32(14-16-33)21-7-3-2-4-8-21/h2-4,7-8,11-12,17-18,22,25H,5-6,9-10,13-16H2,1H3,(H,28,35) ADHPEXKPDZDCGO-UHFFFAOYSA-N 41755 3-[(1-Cyclopentyl-1H-tetrazol-5-yl)-(4-phenyl-piperazin-1-yl)-methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyl-5-tetrazolyl)-(4-phenyl-1-piperazinyl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazino)methyl]-7-methyl-carbostyril::MLS000071942::SMR000002493::cid_650853 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41755&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 650853 252622476 ZINC19221931 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78009 CCn1c(SCC(N)=O)nnc1-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C17H24N6O3S2/c1-3-23-16(19-20-17(23)27-12-15(18)24)13-4-6-14(7-5-13)28(25,26)22-10-8-21(2)9-11-22/h4-7H,3,8-12H2,1-2H3,(H2,18,24) ZALDGZDSUBRSKA-UHFFFAOYSA-N 41756 2-[[4-ethyl-5-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide::2-[[4-ethyl-5-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,2,4-triazol-3-yl]sulfanyl]ethanamide::2-[[4-ethyl-5-[4-(4-methylpiperazino)sulfonylphenyl]-1,2,4-triazol-3-yl]thio]acetamide::2-[[4-ethyl-5-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,2,4-triazol-3-yl]thio]acetamide::2-{4-Ethyl-5-[4-(4-methyl-piperazine-1-sulfonyl)-phenyl]-4H-[1,2,4]triazol-3-ylsulfanyl}-acetamide::MLS000072580::SMR000002266::cid_651311 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41756&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 651311 252622477 ZINC36296032 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78010 CCC(=O)N1CCN(CC1)c1ccc(NC(=O)c2ccc3OCOc3c2)cc1 InChI=1S/C21H23N3O4/c1-2-20(25)24-11-9-23(10-12-24)17-6-4-16(5-7-17)22-21(26)15-3-8-18-19(13-15)28-14-27-18/h3-8,13H,2,9-12,14H2,1H3,(H,22,26) OHJWZEMHHPSNLZ-UHFFFAOYSA-N 41757 Benzo[1,3]dioxole-5-carboxylic acid [4-(4-propionyl-piperazin-1-yl)-phenyl]-amide::MLS000033956::N-[4-(4-propanoylpiperazin-1-yl)phenyl]-1,3-benzodioxole-5-carboxamide::N-[4-(4-propionylpiperazino)phenyl]-piperonylamide::N-[4-[4-(1-oxopropyl)-1-piperazinyl]phenyl]-1,3-benzodioxole-5-carboxamide::SMR000014586::cid_652011 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41757&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 652011 252622478 ZINC00809572 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78011 CCOC(=O)Cc1csc(NC(=O)CSc2nnc(o2)-c2ccc(F)cc2)n1 InChI=1S/C17H15FN4O4S2/c1-2-25-14(24)7-12-8-27-16(19-12)20-13(23)9-28-17-22-21-15(26-17)10-3-5-11(18)6-4-10/h3-6,8H,2,7,9H2,1H3,(H,19,20,23) QBJGPSUBFYSVCP-UHFFFAOYSA-N 41758 (2-{2-[5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-acetylamino}-thiazol-4-yl)-acetic acid ethyl ester::2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester::2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetyl]amino]thiazol-4-yl]acetic acid ethyl ester::MLS000071801::SMR000003120::cid_653271::ethyl 2-[2-[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]-1,3-thiazol-4-yl]ethanoate::ethyl 2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]-1,3-thiazol-4-yl]acetate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41758&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 653271 252622479 ZINC04375512 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78012 COc1ccc(CC2NCCC3(O)CCCCC23)cc1 InChI=1S/C17H25NO2/c1-20-14-7-5-13(6-8-14)12-16-15-4-2-3-9-17(15,19)10-11-18-16/h5-8,15-16,18-19H,2-4,9-12H2,1H3 PANQQHGRCGEZCM-UHFFFAOYSA-N 41759 1-(4-Methoxy-benzyl)-octahydro-isoquinolin-4a-ol::1-[(4-methoxyphenyl)methyl]-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol::1-p-anisyl-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol::MLS000074557::SMR000014065::cid_655005 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41759&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655005 252622480 ZINC04290960 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78013 OC(=O)C1(CCC(=O)C1)c1ccccc1 InChI=1S/C12H12O3/c13-10-6-7-12(8-10,11(14)15)9-4-2-1-3-5-9/h1-5H,6-8H2,(H,14,15) GZFDVSDSPLDDJS-UHFFFAOYSA-N 41760 3-Oxo-1-phenyl-cyclopentanecarboxylic acid::3-keto-1-phenyl-cyclopentanecarboxylic acid::3-oxidanylidene-1-phenyl-cyclopentane-1-carboxylic acid::3-oxo-1-phenyl-1-cyclopentanecarboxylic acid::3-oxo-1-phenylcyclopentane-1-carboxylic acid::MLS000032541::SMR000009429::cid_655176 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41760&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655176 252622481 ZINC00328209 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78014 CCCSc1nc(N2CCOCC2)c2CCCCc2c1C#N InChI=1S/C17H23N3OS/c1-2-11-22-17-15(12-18)13-5-3-4-6-14(13)16(19-17)20-7-9-21-10-8-20/h2-11H2,1H3 GBLQTUPKPFDZPX-UHFFFAOYSA-N 37310 1-(4-morpholinyl)-3-(propylthio)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::1-morpholin-4-yl-3-propylsulfanyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::1-morpholino-3-(propylthio)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::MLS000071300::SMR000039075::cid_658137 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37310&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 658137 252618281 ZINC20826934 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78015 CC1(C)CC(=O)C=C(C1)NCc1ccncc1 InChI=1S/C14H18N2O/c1-14(2)8-12(7-13(17)9-14)16-10-11-3-5-15-6-4-11/h3-7,16H,8-10H2,1-2H3 CEJRNMJRBUFLIR-UHFFFAOYSA-N 41762 5,5-dimethyl-3-(4-pyridylmethylamino)cyclohex-2-en-1-one::5,5-dimethyl-3-(pyridin-4-ylmethylamino)-1-cyclohex-2-enone::5,5-dimethyl-3-(pyridin-4-ylmethylamino)cyclohex-2-en-1-one::MLS000038448::SMR000036470::cid_658329 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41762&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 658329 252622483 ZINC04083056 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78016 Cc1ccc(cc1)-n1c(O)c(C=NCCN2CCOCC2)c(=O)[nH]c1=O InChI=1S/C18H22N4O4/c1-13-2-4-14(5-3-13)22-17(24)15(16(23)20-18(22)25)12-19-6-7-21-8-10-26-11-9-21/h2-5,12,24H,6-11H2,1H3,(H,20,23,25) KJUSUBNBSAGLQB-UHFFFAOYSA-N 41763 (5E)-1-(4-methylphenyl)-5-[(2-morpholin-4-ylethylamino)methylidene]-1,3-diazinane-2,4,6-trione::(5E)-1-(4-methylphenyl)-5-[[2-(4-morpholinyl)ethylamino]methylidene]-1,3-diazinane-2,4,6-trione::(5E)-5-[(2-morpholinoethylamino)methylene]-1-(p-tolyl)barbituric acid::MLS000036795::SMR000040602::cid_5389133 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41763&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5389133 252622484 ZINC19994468 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78017 COC(=O)CCc1c(C)[nH]c(=S)[nH]c1=O InChI=1S/C9H12N2O3S/c1-5-6(3-4-7(12)14-2)8(13)11-9(15)10-5/h3-4H2,1-2H3,(H2,10,11,13,15) ISRRLTIEWOHRNX-UHFFFAOYSA-N 41764 3-(4-keto-6-methyl-2-thioxo-1H-pyrimidin-5-yl)propionic acid methyl ester::3-(6-methyl-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanoic acid methyl ester::MLS000077573::SMR000034647::cid_660631::methyl 3-(6-methyl-4-oxidanylidene-2-sulfanylidene-1H-pyrimidin-5-yl)propanoate::methyl 3-(6-methyl-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41764&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 660631 252622485 ZINC17887074 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78018 CCOC(=O)c1ccc(NC(=O)c2c(O)[nH]c(=O)[nH]c2=O)cc1 InChI=1S/C14H13N3O6/c1-2-23-13(21)7-3-5-8(6-4-7)15-10(18)9-11(19)16-14(22)17-12(9)20/h3-6H,2H2,1H3,(H,15,18)(H3,16,17,19,20,22) XWZUFKMEGYKBSH-UHFFFAOYSA-N 41765 4-[(6-hydroxy-2,4-diketo-1H-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::4-[[(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid ethyl ester::MLS000040367::SMR000058126::cid_662817::ethyl 4-[(6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carbonyl)amino]benzoate::ethyl 4-[[6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens 2276.99995 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41765&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 662817 252622486 ZINC06499020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78019 FC(F)(F)C1(NC(=O)c2ccco2)NC(=O)N(CC2CCCCC2)C1=O InChI=1S/C16H18F3N3O4/c17-16(18,19)15(20-12(23)11-7-4-8-26-11)13(24)22(14(25)21-15)9-10-5-2-1-3-6-10/h4,7-8,10H,1-3,5-6,9H2,(H,20,23)(H,21,25) VOKFQDFDAZVPOY-UHFFFAOYSA-N 41766 MLS000040678::N-[1-(cyclohexylmethyl)-2,5-bis(oxidanylidene)-4-(trifluoromethyl)imidazolidin-4-yl]furan-2-carboxamide::N-[1-(cyclohexylmethyl)-2,5-diketo-4-(trifluoromethyl)imidazolidin-4-yl]-2-furamide::N-[1-(cyclohexylmethyl)-2,5-dioxo-4-(trifluoromethyl)-4-imidazolidinyl]-2-furancarboxamide::N-[1-(cyclohexylmethyl)-2,5-dioxo-4-(trifluoromethyl)imidazolidin-4-yl]furan-2-carboxamide::SMR000044833::cid_663976 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41766&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 663976 252622487 ZINC02420569 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78020 O=C(CN1C(=O)c2ccccc2C1=O)N1CCN(CC1)c1nnc(-c2ccccc2)c2ccccc12 InChI=1S/C28H23N5O3/c34-24(18-33-27(35)22-12-6-7-13-23(22)28(33)36)31-14-16-32(17-15-31)26-21-11-5-4-10-20(21)25(29-30-26)19-8-2-1-3-9-19/h1-13H,14-18H2 IXQKLGBUUZVOSE-UHFFFAOYSA-N 41767 2-[2-keto-2-[4-(4-phenylphthalazin-1-yl)piperazino]ethyl]isoindoline-1,3-quinone::2-[2-oxidanylidene-2-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]ethyl]isoindole-1,3-dione::2-[2-oxo-2-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethyl]isoindole-1,3-dione::2-[2-oxo-2-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]ethyl]isoindole-1,3-dione::MLS000080299::SMR000035392::cid_664563 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41767&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 664563 252622488 ZINC02393309 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78021 CC(C)N(Cc1cc2ccccc2[nH]c1=O)C(=O)c1cccnc1 InChI=1S/C19H19N3O2/c1-13(2)22(19(24)15-7-5-9-20-11-15)12-16-10-14-6-3-4-8-17(14)21-18(16)23/h3-11,13H,12H2,1-2H3,(H,21,23) YRUNVDQFBNTJJU-UHFFFAOYSA-N 41768 MLS000040805::N-[(2-oxidanylidene-1H-quinolin-3-yl)methyl]-N-propan-2-yl-pyridine-3-carboxamide::N-[(2-oxo-1H-quinolin-3-yl)methyl]-N-propan-2-yl-3-pyridinecarboxamide::N-[(2-oxo-1H-quinolin-3-yl)methyl]-N-propan-2-ylpyridine-3-carboxamide::N-isopropyl-N-[(2-keto-1H-quinolin-3-yl)methyl]nicotinamide::SMR000045745::cid_664836 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41768&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 664836 252622489 ZINC08619780 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78022 CN1CC2(Cc3cc(C)ccc13)C(=O)NC(=O)N(C2=O)c1ccccc1C InChI=1S/C21H21N3O3/c1-13-8-9-17-15(10-13)11-21(12-23(17)3)18(25)22-20(27)24(19(21)26)16-7-5-4-6-14(16)2/h4-10H,11-12H2,1-3H3,(H,22,25,27) PWOCMFZIMZKXHI-UHFFFAOYSA-N 41769 1',6'-dimethyl-1-(2-methylphenyl)spiro[1,3-diazinane-5,3'-2,4-dihydroquinoline]-2,4,6-trione::1,6-dimethyl-1'-(o-tolyl)spiro[2,4-dihydroquinoline-3,5'-hexahydropyrimidine]-2',4',6'-trione::MLS000042257::SMR000047525::cid_666205 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41769&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 666205 252622490 ZINC09087711 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78023 CN1C(=O)N(C)C(=O)C2(Sc3ccccc3C2=O)C1=O InChI=1S/C13H10N2O4S/c1-14-10(17)13(11(18)15(2)12(14)19)9(16)7-5-3-4-6-8(7)20-13/h3-6H,1-2H3 AOJMVFZSESQXSW-UHFFFAOYSA-N 41770 1',3'-dimethylspiro[benzothiophene-2,5'-hexahydropyrimidine]-2',3,4',6'-diquinone::1,3-dimethylspiro[1,3-diazinane-5,2'-1-benzothiophene]-2,3',4,6-tetrone::MLS000055669::SMR000060674::cid_2324605 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41770&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2324605 252622491 ZINC03199325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78024 C(Nc1ccccc1)c1nnc2CCCCCn12 InChI=1S/C14H18N4/c1-3-7-12(8-4-1)15-11-14-17-16-13-9-5-2-6-10-18(13)14/h1,3-4,7-8,15H,2,5-6,9-11H2 OOJNELXWRKRYSI-UHFFFAOYSA-N 41771 MLS000057041::N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)aniline::SMR000060400::cid_2310790::phenyl(6,7,8,9-tetrahydro-5H-[1,2,4]triazol[4,3-a]azepin-3-ylmethyl)amine Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41771&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2310790 252622492 ZINC03171849 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78025 CCNC(=O)NC(=O)C(C)OC(=O)c1cccnc1SC InChI=1S/C13H17N3O4S/c1-4-14-13(19)16-10(17)8(2)20-12(18)9-6-5-7-15-11(9)21-3/h5-8H,4H2,1-3H3,(H2,14,16,17,19) MODWYEMRBXFKPQ-UHFFFAOYSA-N 41772 2-(methylthio)-3-pyridinecarboxylic acid [1-(ethylcarbamoylamino)-1-oxopropan-2-yl] ester::2-(methylthio)nicotinic acid [2-(ethylcarbamoylamino)-2-keto-1-methyl-ethyl] ester::MLS000053625::SMR000066587::[1-(ethylcarbamoylamino)-1-oxidanylidene-propan-2-yl] 2-methylsulfanylpyridine-3-carboxylate::[1-(ethylcarbamoylamino)-1-oxopropan-2-yl] 2-methylsulfanylpyridine-3-carboxylate::cid_2998051 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41772&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2998051 252622493 ZINC02640951 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78026 OC(=O)c1ccc(CNC(=O)CN2C(=O)COc3ccccc23)cc1 InChI=1S/C18H16N2O5/c21-16(19-9-12-5-7-13(8-6-12)18(23)24)10-20-14-3-1-2-4-15(14)25-11-17(20)22/h1-8H,9-11H2,(H,19,21)(H,23,24) BXGZDQAFFSEREH-UHFFFAOYSA-N 41773 4-[[2-(3-oxidanylidene-1,4-benzoxazin-4-yl)ethanoylamino]methyl]benzoic acid::4-[[[1-oxo-2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]amino]methyl]benzoic acid::4-[[[2-(3-keto-1,4-benzoxazin-4-yl)acetyl]amino]methyl]benzoic acid::4-[[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]methyl]benzoic acid::MLS000056601::SMR000064585::cid_2526829 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41773&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2526829 252622494 ZINC03407963 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78027 Brc1ccc(s1)S(=O)(=O)NCC(=O)N1CCCC1 InChI=1S/C10H13BrN2O3S2/c11-8-3-4-10(17-8)18(15,16)12-7-9(14)13-5-1-2-6-13/h3-4,12H,1-2,5-7H2 YFADDZBVQYUEMH-UHFFFAOYSA-N 41774 5-bromanyl-N-(2-oxidanylidene-2-pyrrolidin-1-yl-ethyl)thiophene-2-sulfonamide::5-bromo-N-(2-keto-2-pyrrolidino-ethyl)thiophene-2-sulfonamide::5-bromo-N-(2-oxo-2-pyrrolidin-1-ylethyl)thiophene-2-sulfonamide::5-bromo-N-[2-oxo-2-(1-pyrrolidinyl)ethyl]-2-thiophenesulfonamide::MLS000090539::SMR000025143::cid_3237147 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41774&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3237147 252622495 ZINC02602308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78028 OC1(NC(=O)c2ccccc2)C(=O)c2ccccc2C1=O InChI=1S/C16H11NO4/c18-13-11-8-4-5-9-12(11)14(19)16(13,21)17-15(20)10-6-2-1-3-7-10/h1-9,21H,(H,17,20) FICSYWUBABJDHB-UHFFFAOYSA-N 32085 MLS000085603::N-(2-hydroxy-1,3-diketo-indan-2-yl)benzamide::N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide::N-(2-hydroxy-1,3-dioxo-2-indenyl)benzamide::N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide::N-[2-oxidanyl-1,3-bis(oxidanylidene)inden-2-yl]benzamide::SMR000020538::cid_3237318 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3237318 252615537 ZINC03647975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78029 CC(C(=O)N1CCCCC1)n1nc(C)c2sc3ccccc3c2c1=O InChI=1S/C19H21N3O2S/c1-12-17-16(14-8-4-5-9-15(14)25-17)19(24)22(20-12)13(2)18(23)21-10-6-3-7-11-21/h4-5,8-9,13H,3,6-7,10-11H2,1-2H3 DOTOMXRXJJNUOG-UHFFFAOYSA-N 35390 2-(2-keto-1-methyl-2-piperidino-ethyl)-4-methyl-benzothiopheno[2,3-d]pyridazin-1-one::4-methyl-2-(1-methyl-2-oxo-2-piperidin-1-ylethyl)[1]benzothieno[2,3-d]pyridazin-1(2H)-one::4-methyl-2-(1-oxidanylidene-1-piperidin-1-yl-propan-2-yl)-[1]benzothiolo[2,3-d]pyridazin-1-one::4-methyl-2-(1-oxo-1-piperidin-1-ylpropan-2-yl)-[1]benzothiolo[2,3-d]pyridazin-1-one::4-methyl-2-[1-oxo-1-(1-piperidinyl)propan-2-yl]-[1]benzothiolo[2,3-d]pyridazin-1-one::MLS000093662::SMR000029280::cid_3238280 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35390&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3238280 252617659 ZINC04103920 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78030 CCn1ccc(n1)C(=O)Nc1ccc(cc1)N(C)C(C)=O InChI=1S/C15H18N4O2/c1-4-19-10-9-14(17-19)15(21)16-12-5-7-13(8-6-12)18(3)11(2)20/h5-10H,4H2,1-3H3,(H,16,21) ITHLLNAEGXABNZ-UHFFFAOYSA-N 41775 MLS000043435::N-[4-[acetyl(methyl)amino]phenyl]-1-ethyl-3-pyrazolecarboxamide::N-[4-[acetyl(methyl)amino]phenyl]-1-ethyl-pyrazole-3-carboxamide::N-[4-[acetyl(methyl)amino]phenyl]-1-ethylpyrazole-3-carboxamide::N-[4-[ethanoyl(methyl)amino]phenyl]-1-ethyl-pyrazole-3-carboxamide::N-{4-[acetyl(methyl)amino]phenyl}-1-ethyl-1H-pyrazole-3-carboxamide::SMR000020252::cid_3238912 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41775&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3238912 252622496 ZINC00205154 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78031 O=C1CCn2cnc3cccc4ccc1c2c34 InChI=1S/C14H10N2O/c17-12-6-7-16-8-15-11-3-1-2-9-4-5-10(12)14(16)13(9)11/h1-5,8H,6-7H2 HBIWCEFNSGRROL-UHFFFAOYSA-N 34608 7,8-dihydro-9H-pyrido[1,2,3-cd]perimidin-9-one::MLS000044006::SMR000021417::cid_677487 Serine/threonine-protein kinase PLK1 Homo sapiens 25099.00093 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34608&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 677487 242052897 ZINC00041157 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78032 CCn1cnc2sc(C(=O)N3CCN(CC3)c3ccc(OC)cc3)c(C)c2c1=O InChI=1S/C21H24N4O3S/c1-4-23-13-22-19-17(20(23)26)14(2)18(29-19)21(27)25-11-9-24(10-12-25)15-5-7-16(28-3)8-6-15/h5-8,13H,4,9-12H2,1-3H3 OUTGETYLJYFRDG-UHFFFAOYSA-N 41776 3-ethyl-6-[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl-5-methyl-thieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methyl-thieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methylthieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]-5-methyl-4-thieno[2,3-d]pyrimidinone::3-ethyl-6-{[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl}-5-methylthieno[2,3-d]pyrimidin-4(3H)-one::MLS000089815::SMR000024433::cid_3241114 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41776&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3241114 252622497 ZINC04056947 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78033 NC(=O)C1(CCN(CC1)C(=O)NC1CCCCC1)N1CCCCC1 InChI=1S/C18H32N4O2/c19-16(23)18(22-11-5-2-6-12-22)9-13-21(14-10-18)17(24)20-15-7-3-1-4-8-15/h15H,1-14H2,(H2,19,23)(H,20,24) LNEFWEVPXMONGI-UHFFFAOYSA-N 41778 1-N-cyclohexyl-4-piperidin-1-ylpiperidine-1,4-dicarboxamide::MLS000094250::N-cyclohexyl-4-piperidino-piperidine-1,4-dicarboxamide::N1-cyclohexyl-4-(1-piperidinyl)piperidine-1,4-dicarboxamide::N1-cyclohexyl-4-piperidin-1-yl-piperidine-1,4-dicarboxamide::N~1~'-cyclohexyl-1,4'-bipiperidine-1',4'-dicarboxamide::SMR000029840::cid_3242636 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41778&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3242636 252622499 ZINC04077168 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78034 CC(=O)N1CCc2cc(Br)cc(c12)S(=O)(=O)NCc1ccccn1 InChI=1S/C16H16BrN3O3S/c1-11(21)20-7-5-12-8-13(17)9-15(16(12)20)24(22,23)19-10-14-4-2-3-6-18-14/h2-4,6,8-9,19H,5,7,10H2,1H3 WARNLUCAHADWDF-UHFFFAOYSA-N 41779 1-acetyl-5-bromo-N-(2-pyridinylmethyl)-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-(2-pyridylmethyl)indoline-7-sulfonamide::1-acetyl-5-bromo-N-(pyridin-2-ylmethyl)-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-(pyridin-2-ylmethyl)indoline-7-sulfonamide::5-bromanyl-1-ethanoyl-N-(pyridin-2-ylmethyl)-2,3-dihydroindole-7-sulfonamide::MLS000086257::SMR000021766::cid_3242806 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41779&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3242806 252622500 ZINC02456155 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78035 CC(C)OCCCNC(=O)c1ccc(NC(=O)C2CCCO2)cc1 InChI=1S/C18H26N2O4/c1-13(2)23-12-4-10-19-17(21)14-6-8-15(9-7-14)20-18(22)16-5-3-11-24-16/h6-9,13,16H,3-5,10-12H2,1-2H3,(H,19,21)(H,20,22) NNNDGXJQBMEKOL-UHFFFAOYSA-N 41780 MLS000086701::N-(4-{[(3-isopropoxypropyl)amino]carbonyl}phenyl)tetrahydrofuran-2-carboxamide::N-[4-(3-isopropoxypropylcarbamoyl)phenyl]tetrahydrofuran-2-carboxamide::N-[4-(3-propan-2-yloxypropylcarbamoyl)phenyl]oxolane-2-carboxamide::N-[4-[oxo-(3-propan-2-yloxypropylamino)methyl]phenyl]-2-oxolanecarboxamide::SMR000022741::cid_3244061 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41780&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3244061 252622501 ZINC03906325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78036 Cc1ccc(Cl)cc1N1CCN(CC1)S(=O)(=O)c1ccc2n(C)c(=O)oc2c1 InChI=1S/C19H20ClN3O4S/c1-13-3-4-14(20)11-17(13)22-7-9-23(10-8-22)28(25,26)15-5-6-16-18(12-15)27-19(24)21(16)2/h3-6,11-12H,7-10H2,1-2H3 CPYIYHOKMIZHAD-UHFFFAOYSA-N 41781 6-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[4-(5-chloro-2-methyl-phenyl)piperazino]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[[4-(5-chloro-2-methylphenyl)-1-piperazinyl]sulfonyl]-3-methyl-1,3-benzoxazol-2-one::6-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-3-methyl-1,3-benzoxazol-2(3H)-one::MLS000092349::SMR000027426::cid_2983872 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41781&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2983872 252622502 ZINC04058144 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78037 CCC(Sc1nc2nnc(C)c2c(N)n1-c1cccc(Cl)c1)C(=O)NCCOC InChI=1S/C19H23ClN6O2S/c1-4-14(18(27)22-8-9-28-3)29-19-23-17-15(11(2)24-25-17)16(21)26(19)13-7-5-6-12(20)10-13/h5-7,10,14H,4,8-9,21H2,1-3H3,(H,22,27) LXNUZWHEMOKYNJ-UHFFFAOYSA-N 41782 2-[4-amino-5-(3-chlorophenyl)-3-methylpyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl-N-(2-methoxyethyl)butanamide::2-[4-azanyl-5-(3-chlorophenyl)-3-methyl-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl-N-(2-methoxyethyl)butanamide::2-[[4-amino-5-(3-chlorophenyl)-3-methyl-6-pyrazolo[3,4-d]pyrimidinyl]thio]-N-(2-methoxyethyl)butanamide::2-[[4-amino-5-(3-chlorophenyl)-3-methyl-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-N-(2-methoxyethyl)butyramide::2-{[5-(3-chlorophenyl)-4-imino-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio}-N-(2-methoxyethyl)butanamide::MLS000047108::SMR000033119::cid_3245367 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41782&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3245367 252622503 ZINC49539778 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78038 CC1Cn2c(S1)nnc2-c1cc2ccccc2cc1O InChI=1S/C15H13N3OS/c1-9-8-18-14(16-17-15(18)20-9)12-6-10-4-2-3-5-11(10)7-13(12)19/h2-7,9,19H,8H2,1H3 QTSVSHZDVQRJCV-UHFFFAOYSA-N 41783 (3E)-3-(6-methyl-5,6-dihydro-2H-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-ylidene)naphthalen-2-one::(3E)-3-(6-methyl-5,6-dihydro-2H-thiazolo[2,3-c][1,2,4]triazol-3-ylidene)-2-naphthalenone::(3E)-3-(6-methyl-5,6-dihydro-2H-thiazolo[2,3-c][1,2,4]triazol-3-ylidene)naphthalen-2-one::3-(6-methyl-5,6-dihydro[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)-2-naphthol::MLS000066435::SMR000081402::cid_5771713 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41783&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5771713 252622504 ZINC12467700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78039 Cc1nn2c(ncc(NC(=O)c3ccc(C)cc3)c2=O)s1 InChI=1S/C14H12N4O2S/c1-8-3-5-10(6-4-8)12(19)16-11-7-15-14-18(13(11)20)17-9(2)21-14/h3-7H,1-2H3,(H,16,19) MLXGFKLTQYTDMA-UHFFFAOYSA-N 41784 4-methyl-N-(2-methyl-5-oxidanylidene-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::4-methyl-N-(2-methyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::4-methyl-N-(2-methyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::MLS000100118::N-(5-keto-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)-4-methyl-benzamide::SMR000081907::cid_2233157 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41784&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2233157 252622505 ZINC02880962 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78040 CC(C)=CC(=O)NCCc1ccccc1 InChI=1S/C13H17NO/c1-11(2)10-13(15)14-9-8-12-6-4-3-5-7-12/h3-7,10H,8-9H2,1-2H3,(H,14,15) FCKSARQRQMJRHX-UHFFFAOYSA-N 41785 3-methyl-N-(2-phenylethyl)-2-butenamide::3-methyl-N-(2-phenylethyl)but-2-enamide::3-methyl-N-phenethyl-but-2-enamide::MLS000089152::SMR000072849::cid_731815 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41785&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 731815 252622506 ZINC00145632 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78041 Cc1ccccc1NS(=O)(=O)c1cc(ccc1C)C(=O)NCc1ccco1 InChI=1S/C20H20N2O4S/c1-14-6-3-4-8-18(14)22-27(24,25)19-12-16(10-9-15(19)2)20(23)21-13-17-7-5-11-26-17/h3-12,22H,13H2,1-2H3,(H,21,23) YRQJWUOJVVUYMP-UHFFFAOYSA-N 41786 MLS000052108::N-(2-furanylmethyl)-4-methyl-3-[(2-methylphenyl)sulfamoyl]benzamide::N-(2-furfuryl)-4-methyl-3-(o-tolylsulfamoyl)benzamide::N-(2-furylmethyl)-4-methyl-3-{[(2-methylphenyl)amino]sulfonyl}benzamide::N-(furan-2-ylmethyl)-4-methyl-3-[(2-methylphenyl)sulfamoyl]benzamide::SMR000081430::cid_1251601 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41786&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1251601 252622507 ZINC01061586 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78042 CCOC(=O)c1cc2C(=O)c3ccccc3-n2c1N InChI=1S/C14H12N2O3/c1-2-19-14(18)9-7-11-12(17)8-5-3-4-6-10(8)16(11)13(9)15/h3-7H,2,15H2,1H3 NLOFNKPOURZRLR-UHFFFAOYSA-N 41787 1-amino-4-keto-pyrrol[1,2-a]indole-2-carboxylic acid ethyl ester::1-amino-4-oxo-2-pyrrolo[1,2-a]indolecarboxylic acid ethyl ester::MLS000058819::SMR000069085::cid_611015::ethyl 1-amino-4-oxopyrrolo[1,2-a]indole-2-carboxylate::ethyl 1-azanyl-4-oxidanylidene-pyrrolo[1,2-a]indole-2-carboxylate::ethyl 3-amino-9-oxo-9H-pyrrolo[1,2-a]indole-2-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens 19927.9995 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41787&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 611015 252622508 ZINC00285539 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78043 C\C(=C/C(=O)Nc1cc(C)on1)c1ccccc1 InChI=1S/C14H14N2O2/c1-10(12-6-4-3-5-7-12)8-14(17)15-13-9-11(2)18-16-13/h3-9H,1-2H3,(H,15,16,17)/b10-8+ PEFNMKYDZNYGDS-CSKARUKUSA-N 41788 (E)-N-(5-methyl-1,2-oxazol-3-yl)-3-phenyl-but-2-enamide::(E)-N-(5-methyl-1,2-oxazol-3-yl)-3-phenylbut-2-enamide::(E)-N-(5-methyl-3-isoxazolyl)-3-phenyl-2-butenamide::(E)-N-(5-methylisoxazol-3-yl)-3-phenyl-but-2-enamide::MLS000089139::SMR000072835::cid_891479 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41788&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 891479 252622509 ZINC00467035 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78044 CCc1nc2cc(Cl)c(Cl)cc2[nH]1 InChI=1S/C9H8Cl2N2/c1-2-9-12-7-3-5(10)6(11)4-8(7)13-9/h3-4H,2H2,1H3,(H,12,13) TUAVLJUMDKFUGC-UHFFFAOYSA-N 41789 5,6-bis(chloranyl)-2-ethyl-1H-benzimidazole::5,6-dichloro-2-ethyl-1H-benzimidazole::MLS000064722::SMR000077529::cid_972654 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41789&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 972654 252622510 ZINC00612976 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78045 COc1ccc(cc1)S(=O)(=O)N(C)CC(=O)Nc1ccccc1C(F)(F)F InChI=1S/C17H17F3N2O4S/c1-22(27(24,25)13-9-7-12(26-2)8-10-13)11-16(23)21-15-6-4-3-5-14(15)17(18,19)20/h3-10H,11H2,1-2H3,(H,21,23) SCASZLCSYABLPV-UHFFFAOYSA-N 41790 2-[(4-methoxyphenyl)sulfonyl-methyl-amino]-N-[2-(trifluoromethyl)phenyl]acetamide::2-[(4-methoxyphenyl)sulfonyl-methyl-amino]-N-[2-(trifluoromethyl)phenyl]ethanamide::2-[(4-methoxyphenyl)sulfonyl-methylamino]-N-[2-(trifluoromethyl)phenyl]acetamide::MLS000096640::N~2~-[(4-methoxyphenyl)sulfonyl]-N~2~-methyl-N~1~-[2-(trifluoromethyl)phenyl]glycinamide::SMR000073810::cid_1318352 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41790&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1318352 252622511 ZINC01146983 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78046 COC(=O)CNC(=O)C12CC3(C)CC(C)(CC(C)(C3)C1)C2 InChI=1S/C17H27NO3/c1-14-6-15(2)8-16(3,7-14)11-17(9-14,10-15)13(20)18-5-12(19)21-4/h5-11H2,1-4H3,(H,18,20) YMIFHWGGNONKNU-UHFFFAOYSA-N 41791 2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetic acid methyl ester::2-[[oxo-(3,5,7-trimethyl-1-adamantyl)methyl]amino]acetic acid methyl ester::MLS000099463::SMR000074065::cid_2944994::methyl 2-[(3,5,7-trimethyl-1-adamantyl)carbonylamino]ethanoate::methyl 2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetate::methyl N-[(3,5,7-trimethyl-1-adamantyl)carbonyl]glycinate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41791&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2944994 252622512 ZINC04197139 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78047 C=CCn1c2ccccc2c2nnc(SCc3ccc4nonc4c3)nc12 InChI=1S/C19H14N6OS/c1-2-9-25-16-6-4-3-5-13(16)17-18(25)20-19(22-21-17)27-11-12-7-8-14-15(10-12)24-26-23-14/h2-8,10H,1,9,11H2 CBDVEMJKSUSVCA-UHFFFAOYSA-N 41792 5-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanylmethyl]-2,1,3-benzoxadiazole::5-[[(5-allyl-[1,2,4]triazin[5,6-b]indol-3-yl)thio]methyl]benzofurazan::5-[[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl]-2,1,3-benzoxadiazole::5-allyl-3-[(2,1,3-benzoxadiazol-5-ylmethyl)thio]-5H-[1,2,4]triazino[5,6-b]indole::MLS000050812::SMR000078439::cid_2963029 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41792&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2963029 252622513 ZINC00719220 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78048 COc1cccc(OC)c1C(=O)N1CCN(CC1)c1ccccn1 InChI=1S/C18H21N3O3/c1-23-14-6-5-7-15(24-2)17(14)18(22)21-12-10-20(11-13-21)16-8-3-4-9-19-16/h3-9H,10-13H2,1-2H3 SFCMHKMQHYHCNL-UHFFFAOYSA-N 41793 (2,6-dimethoxyphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone::(2,6-dimethoxyphenyl)-[4-(2-pyridinyl)-1-piperazinyl]methanone::(2,6-dimethoxyphenyl)-[4-(2-pyridyl)piperazino]methanone::1-(2,6-dimethoxybenzoyl)-4-(2-pyridinyl)piperazine::MLS000064408::SMR000078044::cid_973595 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41793&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 973595 252622514 ZINC04272463 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78049 Brc1ccc(cc1)N1CC(=O)N(CC(=O)N2CCCc3ccccc23)C1=O InChI=1S/C20H18BrN3O3/c21-15-7-9-16(10-8-15)23-12-19(26)24(20(23)27)13-18(25)22-11-3-5-14-4-1-2-6-17(14)22/h1-2,4,6-10H,3,5,11-13H2 GWERRMPVBJOLKR-UHFFFAOYSA-N 41794 1-(4-bromophenyl)-3-[2-(3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]-2,4-imidazolidinedione::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-keto-ethyl]hydantoin::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxidanylidene-ethyl]imidazolidine-2,4-dione::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]imidazolidine-2,4-dione::MLS000051992::SMR000081238::cid_2228525 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41794&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2228525 252622515 ZINC02876136 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78050 COC(=O)c1cc(NC(=O)C2CCCO2)cc(c1)C(=O)OC InChI=1S/C15H17NO6/c1-20-14(18)9-6-10(15(19)21-2)8-11(7-9)16-13(17)12-4-3-5-22-12/h6-8,12H,3-5H2,1-2H3,(H,16,17) PFCZCPVSHGSOQJ-UHFFFAOYSA-N 41795 5-(tetrahydrofuran-2-carbonylamino)benzene-1,3-dicarboxylic acid dimethyl ester::5-[[oxo(2-oxolanyl)methyl]amino]benzene-1,3-dicarboxylic acid dimethyl ester::MLS000088767::SMR000071907::cid_2932403::dimethyl 5-(oxolan-2-ylcarbonylamino)benzene-1,3-dicarboxylate::dimethyl 5-(oxolane-2-carbonylamino)benzene-1,3-dicarboxylate::dimethyl 5-[(tetrahydro-2-furanylcarbonyl)amino]isophthalate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41795&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2932403 252622516 ZINC00475707 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78051 CCOCCCNC(=O)CCCOc1ccccc1 InChI=1S/C15H23NO3/c1-2-18-12-7-11-16-15(17)10-6-13-19-14-8-4-3-5-9-14/h3-5,8-9H,2,6-7,10-13H2,1H3,(H,16,17) OAJDPKICLPKFMF-UHFFFAOYSA-N 41796 MLS000088375::N-(3-ethoxypropyl)-4-phenoxy-butanamide::N-(3-ethoxypropyl)-4-phenoxy-butyramide::N-(3-ethoxypropyl)-4-phenoxybutanamide::SMR000071739::cid_2179064 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41796&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2179064 252622517 ZINC02818924 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78052 O=c1[nH]cc(COCc2ccccc2)c(=O)[nH]1 InChI=1S/C12H12N2O3/c15-11-10(6-13-12(16)14-11)8-17-7-9-4-2-1-3-5-9/h1-6H,7-8H2,(H2,13,14,15,16) QDNLNNAXVJQLJO-UHFFFAOYSA-N 41797 5-(benzoxymethyl)uracil::5-(phenylmethoxymethyl)-1H-pyrimidine-2,4-dione::5-[(benzyloxy)methyl]-2,4(1H,3H)-pyrimidinedione::MLS000061082::SMR000069595::cid_309850 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41797&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 309850 252622518 ZINC00051670 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78053 Cc1cc(C)n(n1)-c1nnc2SCC(=Nn12)c1ccccc1 InChI=1S/C15H14N6S/c1-10-8-11(2)20(18-10)14-16-17-15-21(14)19-13(9-22-15)12-6-4-3-5-7-12/h3-8H,9H2,1-2H3 KXZFAXRVIUAZFK-UHFFFAOYSA-N 41798 3-(3,5-dimethyl-1-pyrazolyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::3-(3,5-dimethylpyrazol-1-yl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::MLS000063441::SMR000072098::cid_887538 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41798&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 887538 252622519 ZINC00461052 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78054 CCn1ncc(CN2CCN(CC2)C(=O)Nc2ccccc2C(=O)OC)c1C InChI=1S/C20H27N5O3/c1-4-25-15(2)16(13-21-25)14-23-9-11-24(12-10-23)20(27)22-18-8-6-5-7-17(18)19(26)28-3/h5-8,13H,4,9-12,14H2,1-3H3,(H,22,27) DDAPFCDOCILUNS-UHFFFAOYSA-N 41799 2-[[4-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]piperazine-1-carbonyl]amino]benzoic acid methyl ester::2-[[[4-[(1-ethyl-5-methyl-4-pyrazolyl)methyl]-1-piperazinyl]-oxomethyl]amino]benzoic acid methyl ester::MLS000097106::SMR000076600::cid_2206454::methyl 2-[({4-[(1-ethyl-5-methyl-1H-pyrazol-4-yl)methyl]-1-piperazinyl}carbonyl)amino]benzoate::methyl 2-[[4-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]piperazin-1-yl]carbonylamino]benzoate::methyl 2-[[4-[(1-ethyl-5-methylpyrazol-4-yl)methyl]piperazine-1-carbonyl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41799&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2206454 252622520 ZINC22558024 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78055 CC1Cc2ccccc2N1C(=O)c1ccc2n(C)nnc2c1 InChI=1S/C17H16N4O/c1-11-9-12-5-3-4-6-15(12)21(11)17(22)13-7-8-16-14(10-13)18-19-20(16)2/h3-8,10-11H,9H2,1-2H3 LBTDPRQVAPEDGK-UHFFFAOYSA-N 41800 (1-methyl-5-benzotriazolyl)-(2-methyl-2,3-dihydroindol-1-yl)methanone::(1-methylbenzotriazol-5-yl)-(2-methyl-2,3-dihydroindol-1-yl)methanone::(1-methylbenzotriazol-5-yl)-(2-methylindolin-1-yl)methanone::1-methyl-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)carbonyl]-1H-1,2,3-benzotriazole::MLS000063757::SMR000075546::cid_2950653 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41800&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2950653 252622521 ZINC00619278 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78056 CCc1noc(C)c1C(=O)N1CCOCC1 InChI=1S/C11H16N2O3/c1-3-9-10(8(2)16-12-9)11(14)13-4-6-15-7-5-13/h3-7H2,1-2H3 XPRQQOUFQFNJLI-UHFFFAOYSA-N 41801 (3-ethyl-5-methyl-1,2-oxazol-4-yl)-morpholin-4-yl-methanone::(3-ethyl-5-methyl-1,2-oxazol-4-yl)-morpholin-4-ylmethanone::(3-ethyl-5-methyl-4-isoxazolyl)-(4-morpholinyl)methanone::(3-ethyl-5-methyl-isoxazol-4-yl)-morpholino-methanone::4-[(3-ethyl-5-methyl-4-isoxazolyl)carbonyl]morpholine::MLS000065678::SMR000080331::cid_1245299 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41801&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1245299 252622522 ZINC01053681 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78057 NC(=O)Cn1c(nc2ccccc12)S(=O)(=O)Cc1ccccc1 InChI=1S/C16H15N3O3S/c17-15(20)10-19-14-9-5-4-8-13(14)18-16(19)23(21,22)11-12-6-2-1-3-7-12/h1-9H,10-11H2,(H2,17,20) VJBVYGXBOSHOIA-UHFFFAOYSA-N 41802 2-(2-benzylsulfonylbenzimidazol-1-yl)acetamide::2-[2-(benzylsulfonyl)-1H-benzimidazol-1-yl]acetamide::2-[2-(phenylmethyl)sulfonyl-1-benzimidazolyl]acetamide::2-[2-(phenylmethyl)sulfonylbenzimidazol-1-yl]ethanamide::MLS000064097::SMR000075943::cid_713670 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41802&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 713670 252622523 ZINC00107798 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78058 CC(C)(C)NC(=O)CC(CC(O)=O)c1ccccc1 InChI=1S/C15H21NO3/c1-15(2,3)16-13(17)9-12(10-14(18)19)11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,17)(H,18,19) YXIBWSNBWFLHSC-UHFFFAOYSA-N 41803 5-(tert-butylamino)-5-keto-3-phenyl-valeric acid::5-(tert-butylamino)-5-oxidanylidene-3-phenyl-pentanoic acid::5-(tert-butylamino)-5-oxo-3-phenylpentanoic acid::MLS000120585::SMR000097437::cid_3580533 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41803&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3580533 252622524 ZINC03646794 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78059 COc1ccc(Nc2oc(nc2C#N)-c2ccccc2Cl)cc1 InChI=1S/C17H12ClN3O2/c1-22-12-8-6-11(7-9-12)20-17-15(10-19)21-16(23-17)13-4-2-3-5-14(13)18/h2-9,20H,1H3 RXBBQCAWCVEWFQ-UHFFFAOYSA-N 39564 2-(2-chlorophenyl)-5-(4-methoxyanilino)-1,3-oxazole-4-carbonitrile::2-(2-chlorophenyl)-5-(4-methoxyanilino)-4-oxazolecarbonitrile::2-(2-chlorophenyl)-5-(p-anisidino)oxazole-4-carbonitrile::2-(2-chlorophenyl)-5-[(4-methoxyphenyl)amino]-1,3-oxazole-4-carbonitrile::MLS000103052::SMR000018585::cid_946201 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39564&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 946201 252620455 ZINC00544706 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78060 CN(C)c1ccc(cc1)C(=O)Nc1nc2CCCCc2s1 InChI=1S/C16H19N3OS/c1-19(2)12-9-7-11(8-10-12)15(20)18-16-17-13-5-3-4-6-14(13)21-16/h7-10H,3-6H2,1-2H3,(H,17,18,20) ZVKWKVBRZGMCEC-UHFFFAOYSA-N 37501 4-(dimethylamino)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)benzamide::MLS000100704::SMR000017424::cid_746147 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37501&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 746147 252618472 ZINC00189361 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78061 OCC(CO)(CO)N=Cc1cc(Br)ccc1O InChI=1S/C11H14BrNO4/c12-9-1-2-10(17)8(3-9)4-13-11(5-14,6-15)7-16/h1-4,14-17H,5-7H2 VYXIAZMAMSTAGX-UHFFFAOYSA-N 41804 (6E)-4-bromanyl-6-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methylidene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[(2-hydroxy-1,1-dimethylol-ethyl)amino]methylene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]methylidene]-1-cyclohexa-2,4-dienone::(6E)-4-bromo-6-[[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]methylidene]cyclohexa-2,4-dien-1-one::MLS000106424::SMR000103391::cid_5406010 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41804&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5406010 252622525 ZINC13126620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78062 OC(=O)COc1ccc(Br)cc1CN=O InChI=1S/C9H8BrNO4/c10-7-1-2-8(15-5-9(12)13)6(3-7)4-11-14/h1-3H,4-5H2,(H,12,13) KWXZZLFHSHNEHC-UHFFFAOYSA-N 41805 2-[4-bromanyl-2-(hydroxyiminomethyl)phenoxy]ethanoic acid::2-[4-bromo-2-(hydroximinomethyl)phenoxy]acetic acid::2-[4-bromo-2-(hydroxyiminomethyl)phenoxy]acetic acid::MLS000113958::SMR000109848::cid_887160 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41805&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91896517 252622526 ZINC20166683 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78063 O=C(COc1ccccc1)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C18H20N2O5S/c21-18(14-25-16-4-2-1-3-5-16)19-15-6-8-17(9-7-15)26(22,23)20-10-12-24-13-11-20/h1-9H,10-14H2,(H,19,21) WBYAGEJSHNRQAE-UHFFFAOYSA-N 41806 MLS000108227::N-(4-morpholin-4-ylsulfonylphenyl)-2-phenoxy-ethanamide::N-(4-morpholin-4-ylsulfonylphenyl)-2-phenoxyacetamide::N-(4-morpholinosulfonylphenyl)-2-phenoxy-acetamide::N-[4-(4-morpholinylsulfonyl)phenyl]-2-phenoxyacetamide::SMR000104188::cid_1010129 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41806&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1010129 252622527 ZINC00670442 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78064 CC1CCCC(C1)NC1CCCCNC1=O InChI=1S/C13H24N2O/c1-10-5-4-6-11(9-10)15-12-7-2-3-8-14-13(12)16/h10-12,15H,2-9H2,1H3,(H,14,16) QXPOPAWVLRBGAF-UHFFFAOYSA-N 41807 3-[(3-methylcyclohexyl)amino]-2-azepanone::3-[(3-methylcyclohexyl)amino]azepan-2-one::MLS000106622::SMR000110999::cid_2846276 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41807&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2846276 252622528 ZINC04989210 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78065 CC1CN(CCC1=O)C1CC(C)(C)NC(C)(C)C1 InChI=1S/C15H28N2O/c1-11-10-17(7-6-13(11)18)12-8-14(2,3)16-15(4,5)9-12/h11-12,16H,6-10H2,1-5H3 SISQFEZLNOSCNG-UHFFFAOYSA-N 41808 3-methyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-4-piperidinone::3-methyl-1-(2,2,6,6-tetramethyl-4-piperidyl)-4-piperidone::3-methyl-1-(2,2,6,6-tetramethylpiperidin-4-yl)piperidin-4-one::MLS000110137::SMR000106069::cid_547348 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41808&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 547348 252622529 ZINC19798180 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78066 Cc1ccc(OCC(=O)Nc2ccc(cc2)N2CCOCC2)cc1 InChI=1S/C19H22N2O3/c1-15-2-8-18(9-3-15)24-14-19(22)20-16-4-6-17(7-5-16)21-10-12-23-13-11-21/h2-9H,10-14H2,1H3,(H,20,22) YXYYNLLGGPQOKU-UHFFFAOYSA-N 41809 2-(4-methylphenoxy)-N-(4-morpholin-4-ylphenyl)acetamide::2-(4-methylphenoxy)-N-(4-morpholin-4-ylphenyl)ethanamide::2-(4-methylphenoxy)-N-(4-morpholinophenyl)acetamide::2-(4-methylphenoxy)-N-[4-(4-morpholinyl)phenyl]acetamide::MLS000107479::SMR000111845::cid_682558 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41809&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 682558 252622530 ZINC00048261 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78067 OC(=O)C1CCCCC1C(=O)Nc1ccc2OCCOc2c1 InChI=1S/C16H19NO5/c18-15(11-3-1-2-4-12(11)16(19)20)17-10-5-6-13-14(9-10)22-8-7-21-13/h5-6,9,11-12H,1-4,7-8H2,(H,17,18)(H,19,20) LWYYYWNLCLHWQV-UHFFFAOYSA-N 41810 2-(2,3-dihydro-1,4-benzodioxin-6-ylcarbamoyl)cyclohexane-1-carboxylic acid::2-(2,3-dihydro-1,4-benzodioxin-6-ylcarbamoyl)cyclohexanecarboxylic acid::2-[(2,3-dihydro-1,4-benzodioxin-6-ylamino)-oxomethyl]-1-cyclohexanecarboxylic acid::MLS000107960::SMR000103924::cid_2862450 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41810&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2862450 252622531 ZINC00113642 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78068 CCC(C)c1ccc(NC(=O)C2CC2)cc1 InChI=1S/C14H19NO/c1-3-10(2)11-6-8-13(9-7-11)15-14(16)12-4-5-12/h6-10,12H,3-5H2,1-2H3,(H,15,16) FFJKVRCOUHEYOK-UHFFFAOYSA-N 41811 MLS000110184::N-(4-butan-2-ylphenyl)cyclopropanecarboxamide::N-(4-sec-butylphenyl)cyclopropanecarboxamide::SMR000106115::cid_2886949 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41811&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2886949 252622532 ZINC00442522 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78069 COc1ccc(cc1)N(C)C1=NS(=O)(=O)c2ccccc12 InChI=1S/C15H14N2O3S/c1-17(11-7-9-12(20-2)10-8-11)15-13-5-3-4-6-14(13)21(18,19)16-15/h3-10H,1-2H3 LLZMQRONMABMKW-UHFFFAOYSA-N 41812 (1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-(4-methoxy-phenyl)-methyl-amine::(1,1-diketo-1,2-benzothiazol-3-yl)-(4-methoxyphenyl)-methyl-amine::MLS000068583::N-(4-methoxyphenyl)-N-methyl-1,1-bis(oxidanylidene)-1,2-benzothiazol-3-amine::N-(4-methoxyphenyl)-N-methyl-1,1-dioxo-1,2-benzothiazol-3-amine::SMR000122953::cid_785727 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41812&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 785727 252622533 ZINC00282597 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78070 O=C(N1CCCCC1)c1ccc(cc1)-n1cnnn1 InChI=1S/C13H15N5O/c19-13(17-8-2-1-3-9-17)11-4-6-12(7-5-11)18-10-14-15-16-18/h4-7,10H,1-3,8-9H2 JNUBUUVSAUHVCX-UHFFFAOYSA-N 41813 1-piperidinyl-[4-(1-tetrazolyl)phenyl]methanone::MLS000121381::Piperidin-1-yl-(4-tetrazol-1-yl-phenyl)-methanone::SMR000118722::cid_817486::piperidin-1-yl-[4-(1,2,3,4-tetrazol-1-yl)phenyl]methanone::piperidin-1-yl-[4-(tetrazol-1-yl)phenyl]methanone::piperidino-[4-(tetrazol-1-yl)phenyl]methanone Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41813&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 817486 252622534 ZINC00331408 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78071 COc1cc(OC)cc(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C16H24N2O4/c1-20-14-10-13(11-15(12-14)21-2)16(19)17-4-3-5-18-6-8-22-9-7-18/h10-12H,3-9H2,1-2H3,(H,17,19) ZSVNZECOKWHYAB-UHFFFAOYSA-N 41814 3,5-Dimethoxy-N-(3-morpholin-4-yl-propyl)-benzamide::3,5-dimethoxy-N-(3-morpholin-4-ylpropyl)benzamide::3,5-dimethoxy-N-(3-morpholinopropyl)benzamide::3,5-dimethoxy-N-[3-(4-morpholinyl)propyl]benzamide::MLS000121576::SMR000118971::cid_2163734 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2163734 252622535 ZINC19760161 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78072 COc1cc(ccc1-n1cnnn1)S(=O)(=O)N1CCCCCC1 InChI=1S/C14H19N5O3S/c1-22-14-10-12(6-7-13(14)19-11-15-16-17-19)23(20,21)18-8-4-2-3-5-9-18/h6-7,10-11H,2-5,8-9H2,1H3 IANQVUKPSLMWSM-UHFFFAOYSA-N 41815 1-(3-Methoxy-4-tetrazol-1-yl-benzenesulfonyl)-azepane::1-[3-methoxy-4-(1,2,3,4-tetrazol-1-yl)phenyl]sulfonylazepane::1-[3-methoxy-4-(1-tetrazolyl)phenyl]sulfonylazepane::1-[3-methoxy-4-(tetrazol-1-yl)phenyl]sulfonylazepane::MLS000123482::SMR000124037::cid_858983 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41815&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 858983 252622536 ZINC00414808 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78073 Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(Cl)cc1 InChI=1S/C13H10ClN5O2/c1-18-12(20)9-11(16-13(18)21)19(2)17-10(15-9)7-3-5-8(14)6-4-7/h3-6H,1-2H3 UCEGDYDPOSBUTP-UHFFFAOYSA-N 40314 3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone::3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::MLS000523518::SMR000122591::US9073941, 603::cid_460749 Serine/threonine-protein kinase PLK1 Homo sapiens 2460.000038 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40314&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 460749 252621140 ZINC00267651 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78074 Cc1nn(C)c2nc(=O)n(C)c(=O)c2n1 InChI=1S/C8H9N5O2/c1-4-9-5-6(13(3)11-4)10-8(15)12(2)7(5)14/h1-3H3 CPXHNWKHOFNPDO-UHFFFAOYSA-N 34671 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone::MLS000528498::SMR000121073::US9073941, 611::cid_460747 Serine/threonine-protein kinase PLK1 Homo sapiens 14576.00021 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34671&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 460747 252617321 ZINC00490878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78075 Cc1[nH]n2c(nc(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccccc1 InChI=1S/C19H14N4O3/c1-12-18(14-5-3-2-4-6-14)19-20-16(11-17(24)22(19)21-12)13-7-9-15(10-8-13)23(25)26/h2-11,21H,1H3 XISRVALMPPEBHA-UHFFFAOYSA-N 37827 2-methyl-5-(4-nitrophenyl)-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one::5-{4-nitrophenyl}-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one::MLS000547439::SMR000113532::cid_1051569 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37827&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1051569 252618787 ZINC05439269 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78076 CCOC(=O)c1c(C)n(C)c2c1-c1cc(Br)ccc1C(=O)C2=O InChI=1S/C17H14BrNO4/c1-4-23-17(22)12-8(2)19(3)14-13(12)11-7-9(18)5-6-10(11)15(20)16(14)21/h5-7H,4H2,1-3H3 HKEXSVHEPUVAPQ-UHFFFAOYSA-N 40316 8-bromo-2,3-dimethyl-4,5-dioxo-1-benzo[e]indolecarboxylic acid ethyl ester::8-bromo-4,5-diketo-2,3-dimethyl-benz[e]indole-1-carboxylic acid ethyl ester::MLS000548053::SMR000114488::cid_1736381::ethyl 8-bromanyl-2,3-dimethyl-4,5-bis(oxidanylidene)benzo[e]indole-1-carboxylate::ethyl 8-bromo-2,3-dimethyl-4,5-dioxo-4,5-dihydro-3H-benzo[e]indole-1-carboxylate::ethyl 8-bromo-2,3-dimethyl-4,5-dioxobenzo[e]indole-1-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens 10435.00042 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40316&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1736381 252621142 ZINC02075226 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78077 Cc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)c(C)c1 InChI=1S/C22H18N2O3S2/c1-14-9-10-18(15(2)12-14)23-20-13-19(16-6-3-4-7-17(16)22(20)25)24-29(26,27)21-8-5-11-28-21/h3-13,23H,1-2H3 LCGOLHKLWOZZSZ-UHFFFAOYSA-N 41816 (NE)-N-[3-(2,4-dimethylanilino)-4-keto-1-naphthylidene]thiophene-2-sulfonamide::(NE)-N-[3-(2,4-dimethylanilino)-4-oxo-1-naphthalenylidene]-2-thiophenesulfonamide::(NE)-N-[3-(2,4-dimethylanilino)-4-oxonaphthalen-1-ylidene]thiophene-2-sulfonamide::(NE)-N-[3-[(2,4-dimethylphenyl)amino]-4-oxidanylidene-naphthalen-1-ylidene]thiophene-2-sulfonamide::MLS000549894::N-(3-(2,4-dimethylanilino)-4-oxo-1(4H)-naphthalenylidene)-2-thiophenesulfonamide::SMR000113727::cid_9549688 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41816&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9549688 252622537 ZINC13111032 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78078 Oc1ccc2ccc3cccc[n+]3c2c1 InChI=1S/C13H9NO/c15-12-7-5-10-4-6-11-3-1-2-8-14(11)13(10)9-12/h1-9H/p+1 PGMYAFHGARCXKK-UHFFFAOYSA-O 41817 9-benzo[c]quinolizin-11-iumol;iodide::9-hydroxypyrido[1,2-a]quinolinium::MLS000548877::SMR000113700::benzo[c]quinolizin-11-ium-9-ol;iodide::cid_9549757 Serine/threonine-protein kinase PLK1 Homo sapiens 8732.000351 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41817&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 849585 252622538 ZINC00384120 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78079 Clc1cc(c(Cl)s1)-c1ccnc(SCC=C)n1 InChI=1S/C11H8Cl2N2S2/c1-2-5-16-11-14-4-3-8(15-11)7-6-9(12)17-10(7)13/h2-4,6H,1,5H2 QEMZGRCLCNTCII-UHFFFAOYSA-N 41818 2-(allylsulfanyl)-4-(2,5-dichloro-3-thienyl)pyrimidine::2-(allylthio)-4-(2,5-dichloro-3-thienyl)pyrimidine::4-(2,5-dichloro-3-thiophenyl)-2-(prop-2-enylthio)pyrimidine::4-(2,5-dichlorothiophen-3-yl)-2-prop-2-enylsulfanylpyrimidine::4-[2,5-bis(chloranyl)thiophen-3-yl]-2-prop-2-enylsulfanyl-pyrimidine::MLS000540566::SMR000125824::cid_3806023 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41818&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3806023 252622539 ZINC05382813 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78080 Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21 InChI=1S/C14H9NO2/c15-8-5-6-10-9-3-1-2-4-11(9)13(16)14(17)12(10)7-8/h1-7H,15H2 HENHQTJCDFNZOI-UHFFFAOYSA-N 50099737 2-Amino-phenanthrene-9,10-dione::CHEMBL417727::US9073941, 902::cid_254021 Serine/threonine-protein kinase PLK1 Homo sapiens 5899.000168 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099737&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 254021 103996562 CHEMBL417727 ZINC01713558 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78081 CC(C)Sc1nc(N2CCOCC2)c2CN(C)C(C)(C)Cc2c1C#N InChI=1S/C19H28N4OS/c1-13(2)25-18-15(11-20)14-10-19(3,4)22(5)12-16(14)17(21-18)23-6-8-24-9-7-23/h13H,6-10,12H2,1-5H3 VOFFAYCPMVCFGB-UHFFFAOYSA-N 41819 3-(isopropylthio)-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-yl-5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-(4-morpholinyl)-3-(propan-2-ylthio)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-morpholin-4-yl-3-propan-2-ylsulfanyl-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::MLS000552515::SMR000146030::cid_3790338 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41819&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3790338 252622540 ZINC13142403 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78082 Cc1cccc(C)c1NC1=NC(=S)N(c2ccccc2)C11CCOC(C)(C)C1 InChI=1S/C23H27N3OS/c1-16-9-8-10-17(2)19(16)24-20-23(13-14-27-22(3,4)15-23)26(21(28)25-20)18-11-6-5-7-12-18/h5-12H,13-15H2,1-4H3,(H,24,25,28) XOQWQVNJXRZWGS-UHFFFAOYSA-N 41820 4-(2,6-dimethylanilino)-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione::4-[(2,6-dimethylphenyl)amino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione::4-[(Z)-2,6-Dimethyl-phenylimino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diaza-spiro[4.5]decane-2-thione::MLS000552149::SMR000145863::cid_4005418 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41820&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4005418 252622541 ZINC17138319 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78083 O=C(CC1N(CCNC1=O)C(=S)Nc1ccccc1)Nc1ccc2OCCOc2c1 InChI=1S/C21H22N4O4S/c26-19(23-15-6-7-17-18(12-15)29-11-10-28-17)13-16-20(27)22-8-9-25(16)21(30)24-14-4-2-1-3-5-14/h1-7,12,16H,8-11,13H2,(H,22,27)(H,23,26)(H,24,30) BXQVEPADPAZKIN-UHFFFAOYSA-N 41821 2-[1-(anilinocarbonothioyl)-3-oxo-2-piperazinyl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::2-[1-[anilino(sulfanylidene)methyl]-3-oxo-2-piperazinyl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::MLS000538345::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-keto-1-(phenylthiocarbamoyl)piperazin-2-yl]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-oxidanylidene-1-(phenylcarbamothioyl)piperazin-2-yl]ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-oxo-1-(phenylcarbamothioyl)piperazin-2-yl]acetamide::SMR000144382::cid_2968933 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41821&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2968933 252622542 ZINC01079150 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78084 CS(=O)(=O)N1CCN(C\C=C\c2ccccc2)CC1 InChI=1S/C14H20N2O2S/c1-19(17,18)16-12-10-15(11-13-16)9-5-8-14-6-3-2-4-7-14/h2-8H,9-13H2,1H3/b8-5+ FOVOVNHELYBDGP-VMPITWQZSA-N 41822 1-(methylsulfonyl)-4-(3-phenyl-2-propen-1-yl)piperazine::1-[(E)-cinnamyl]-4-mesyl-piperazine::1-methylsulfonyl-4-[(E)-3-phenylprop-2-enyl]piperazine::MLS000530258::SMR000135235::cid_750930 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41822&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 750930 252622543 ZINC19536338 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78085 CCC(=O)Nc1ccccc1C(=O)NC1CCCCC1 InChI=1S/C16H22N2O2/c1-2-15(19)18-14-11-7-6-10-13(14)16(20)17-12-8-4-3-5-9-12/h6-7,10-12H,2-5,8-9H2,1H3,(H,17,20)(H,18,19) PWIYNYQZCMUDNH-UHFFFAOYSA-N 41823 MLS000538265::N-cyclohexyl-2-(1-oxopropylamino)benzamide::N-cyclohexyl-2-(propanoylamino)benzamide::N-cyclohexyl-2-(propionylamino)benzamide::N-cyclohexyl-2-propionamido-benzamide::SMR000144305::cid_974692 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41823&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 974692 252622544 ZINC00615774 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78086 Cc1ccc(CNC(=O)c2cc3c(n2C)c2ccccc2n(C)c3=O)cc1 InChI=1S/C22H21N3O2/c1-14-8-10-15(11-9-14)13-23-21(26)19-12-17-20(24(19)2)16-6-4-5-7-18(16)25(3)22(17)27/h4-12H,13H2,1-3H3,(H,23,26) GOCAPSRBFPHRLB-UHFFFAOYSA-N 41824 1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxidanylidene-pyrrolo[3,2-c]quinoline-2-carboxamide::1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxo-2-pyrrolo[3,2-c]quinolinecarboxamide::1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxopyrrolo[3,2-c]quinoline-2-carboxamide::4-keto-1,5-dimethyl-N-(4-methylbenzyl)pyrrolo[3,2-c]quinoline-2-carboxamide::MLS000522546::SMR000127813::cid_6622575 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41824&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6622575 252622545 ZINC04938861 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 78087 COc1ccc2C(CC(O)=O)OC(=O)c2c1OC InChI=1S/C12H12O6/c1-16-7-4-3-6-8(5-9(13)14)18-12(15)10(6)11(7)17-2/h3-4,8H,5H2,1-2H3,(H,13,14) KAZZPXMHIZJNFS-UHFFFAOYSA-N 41825 (4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl)acetic acid::2-(3-keto-4,5-dimethoxy-phthalan-1-yl)acetic acid::2-(4,5-dimethoxy-3-oxidanylidene-1H-2-benzofuran-1-yl)ethanoic acid::2-(4,5-dimethoxy-3-oxo-1H-2-benzofuran-1-yl)acetic acid::2-(4,5-dimethoxy-3-oxo-1H-isobenzofuran-1-yl)acetic acid::MLS000530421::SMR000135399::cid_2863889 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2T72FVT aid877 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41825&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2863889 252622546 ZINC00434141 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84372 Fc1ccc(Cn2nnnc2CN2CCN(CC2)C2CCCC2)cc1 InChI=1S/C18H25FN6/c19-16-7-5-15(6-8-16)13-25-18(20-21-22-25)14-23-9-11-24(12-10-23)17-3-1-2-4-17/h5-8,17H,1-4,9-14H2 NUVIKTFIUDCSBH-UHFFFAOYSA-N 41747 1-Cyclopentyl-4-[1-(4-fluoro-benzyl)-1H-tetrazol-5-ylmethyl]-piperazine::1-cyclopentyl-4-[[1-(4-fluorobenzyl)tetrazol-5-yl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-1,2,3,4-tetrazol-5-yl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-5-tetrazolyl]methyl]piperazine::1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]tetrazol-5-yl]methyl]piperazine::MLS000073054::SMR000004983::cid_644709 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41747&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 644709 252622468 ZINC22583409 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84373 COc1ccc2c(C)n[nH]c3cccc1c23 InChI=1S/C13H12N2O/c1-8-9-6-7-12(16-2)10-4-3-5-11(13(9)10)15-14-8/h3-7,15H,1-2H3 MXCNJRIUQVTTPS-UHFFFAOYSA-N 31997 6-Methoxy-3-methyl-1H-benzo[de]cinnoline::MLS000027089::SMR000010302::cid_644992 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31997&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 644992 242052843 ZINC04008434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84374 CCC(=O)Nc1ccc(cc1)-c1nnc(SCC(=O)Nc2nccs2)n1C InChI=1S/C17H18N6O2S2/c1-3-13(24)19-12-6-4-11(5-7-12)15-21-22-17(23(15)2)27-10-14(25)20-16-18-8-9-26-16/h4-9H,3,10H2,1-2H3,(H,19,24)(H,18,20,25) CNOUHVBUCKBSLD-UHFFFAOYSA-N 41748 MLS000076456::N-[4-[4-methyl-5-[2-oxidanylidene-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[4-methyl-5-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]sulfanyl-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[4-methyl-5-[[2-oxo-2-(2-thiazolylamino)ethyl]thio]-1,2,4-triazol-3-yl]phenyl]propanamide::N-[4-[5-[[2-keto-2-(thiazol-2-ylamino)ethyl]thio]-4-methyl-1,2,4-triazol-3-yl]phenyl]propionamide::N-{4-[4-Methyl-5-(thiazol-2-ylcarbamoylmethylsulfanyl)-4H-[1,2,4]triazol-3-yl]-phenyl}-propionamide::SMR000015120::cid_646718 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41748&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 646718 252622469 ZINC04510460 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84375 COc1ccccc1C1SCCN1S(=O)(=O)c1cccc(c1)C(F)(F)F InChI=1S/C17H16F3NO3S2/c1-24-15-8-3-2-7-14(15)16-21(9-10-25-16)26(22,23)13-6-4-5-12(11-13)17(18,19)20/h2-8,11,16H,9-10H2,1H3 IANULKJFHGLGOX-UHFFFAOYSA-N 41749 2-(2-Methoxy-phenyl)-3-(3-trifluoromethyl-benzenesulfonyl)-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonyl-1,3-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonyl-thiazolidine::2-(2-methoxyphenyl)-3-[3-(trifluoromethyl)phenyl]sulfonylthiazolidine::MLS000030697::SMR000011601::cid_646735 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41749&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 646735 252622470 ZINC00887292 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84376 Clc1ccc(CC(=O)NCCN2CCCC2)cc1 InChI=1S/C14H19ClN2O/c15-13-5-3-12(4-6-13)11-14(18)16-7-10-17-8-1-2-9-17/h3-6H,1-2,7-11H2,(H,16,18) FCDXYGHRQACESV-UHFFFAOYSA-N 41750 2-(4-Chloro-phenyl)-N-(2-pyrrolidin-1-yl-ethyl)-acetamide::2-(4-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)acetamide;hydrochloride::2-(4-chlorophenyl)-N-(2-pyrrolidin-1-ylethyl)ethanamide;hydrochloride::2-(4-chlorophenyl)-N-(2-pyrrolidinoethyl)acetamide;hydrochloride::2-(4-chlorophenyl)-N-[2-(1-pyrrolidinyl)ethyl]acetamide;hydrochloride::MLS000075628::SMR000013881::cid_6603083 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41750&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 647301 252622471 ZINC02843177 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84377 CNC(=O)CC(C(O)=O)c1ccc(OCC(C)C)cc1 InChI=1S/C15H21NO4/c1-10(2)9-20-12-6-4-11(5-7-12)13(15(18)19)8-14(17)16-3/h4-7,10,13H,8-9H2,1-3H3,(H,16,17)(H,18,19) XQESYXHSGQLCNC-UHFFFAOYSA-N 41751 2-(4-Isobutoxy-phenyl)-N-methyl-succinamic acid::2-(4-isobutoxyphenyl)-4-keto-4-(methylamino)butyric acid::4-(methylamino)-2-[4-(2-methylpropoxy)phenyl]-4-oxidanylidene-butanoic acid::4-(methylamino)-2-[4-(2-methylpropoxy)phenyl]-4-oxobutanoic acid::MLS000068652::SMR000008612::cid_647848 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41751&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 647848 252622472 ZINC04411521 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84378 COc1ccc(cc1S(=O)(=O)Nc1ccc(Cl)cn1)C(C)C InChI=1S/C15H17ClN2O3S/c1-10(2)11-4-6-13(21-3)14(8-11)22(19,20)18-15-7-5-12(16)9-17-15/h4-10H,1-3H3,(H,17,18) XNYRYSBNCKGQLI-UHFFFAOYSA-N 41752 MLS000071127::N-(5-Chloro-pyridin-2-yl)-5-isopropyl-2-methoxy-benzenesulfonamide::N-(5-chloranylpyridin-2-yl)-2-methoxy-5-propan-2-yl-benzenesulfonamide::N-(5-chloro-2-pyridinyl)-2-methoxy-5-propan-2-ylbenzenesulfonamide::N-(5-chloro-2-pyridyl)-5-isopropyl-2-methoxy-benzenesulfonamide::N-(5-chloropyridin-2-yl)-2-methoxy-5-propan-2-ylbenzenesulfonamide::SMR000015187::cid_648225 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41752&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 648225 252622473 ZINC00384700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84379 Cc1ccc(NC(=O)C2CC=CCC2C(=O)N2CCCCC2)cc1 InChI=1S/C20H26N2O2/c1-15-9-11-16(12-10-15)21-19(23)17-7-3-4-8-18(17)20(24)22-13-5-2-6-14-22/h3-4,9-12,17-18H,2,5-8,13-14H2,1H3,(H,21,23) XWRKSKOBCZOXJA-UHFFFAOYSA-N 41753 6-(Piperidine-1-carbonyl)-cyclohex-3-enecarboxylic acid p-tolylamide::6-(piperidine-1-carbonyl)-N-(p-tolyl)cyclohex-3-ene-1-carboxamide::MLS000071126::N-(4-methylphenyl)-6-(piperidine-1-carbonyl)cyclohex-3-ene-1-carboxamide::N-(4-methylphenyl)-6-[oxo(1-piperidinyl)methyl]-1-cyclohex-3-enecarboxamide::N-(4-methylphenyl)-6-piperidin-1-ylcarbonyl-cyclohex-3-ene-1-carboxamide::SMR000010710::cid_648286 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41753&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 648286 252622474 ZINC00054230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84380 O=C1C(Nc2ccccc12)=C1C(=O)c2ccccc2C1=O InChI=1S/C17H9NO3/c19-15-9-5-1-2-6-10(9)16(20)13(15)14-17(21)11-7-3-4-8-12(11)18-14/h1-8,18H XXSJHAICOWNQBL-UHFFFAOYSA-N 32004 2-(3-Oxo-1,3-dihydro-indol-2-ylidene)-indan-1,3-dione::2-(3-ketoindolin-2-ylidene)indane-1,3-quinone::2-(3-oxidanylidene-1H-indol-2-ylidene)indene-1,3-dione::2-(3-oxo-1H-indol-2-ylidene)indene-1,3-dione::MLS000071738::SMR000010447::cid_649556 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32004&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 649556 252615466 ZINC06529695 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84381 COc1ccc(Cn2c3ccccc3sc2=O)cc1 InChI=1S/C15H13NO2S/c1-18-12-8-6-11(7-9-12)10-16-13-4-2-3-5-14(13)19-15(16)17/h2-9H,10H2,1H3 MHFZFKZXERZAKK-UHFFFAOYSA-N 41754 3-(4-Methoxy-benzyl)-3H-benzothiazol-2-one::3-[(4-methoxyphenyl)methyl]-1,3-benzothiazol-2-one::3-p-anisyl-1,3-benzothiazol-2-one::MLS000035042::SMR000015012::cid_649921 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41754&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 649921 252622475 ZINC00814287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84382 Cn1c2cccc3C(=O)c4ccccc4-c(c(NCCO)c1=O)c23 InChI=1S/C19H16N2O3/c1-21-14-8-4-7-13-15(14)16(17(19(21)24)20-9-10-22)11-5-2-3-6-12(11)18(13)23/h2-8,20,22H,9-10H2,1H3 JHRNUMVGSNJFOB-UHFFFAOYSA-N 32006 1-(2-Hydroxy-ethylamino)-3-methyl-3H-naphtho[1,2,3-de]quinoline-2,7-dione::MLS000076121::SMR000013433::cid_650462 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32006&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 650462 242052845 ZINC18141610 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84383 Cc1ccc2cc(C(N3CCN(CC3)c3ccccc3)c3nnnn3C3CCCC3)c(=O)[nH]c2c1 InChI=1S/C27H31N7O/c1-19-11-12-20-18-23(27(35)28-24(20)17-19)25(26-29-30-31-34(26)22-9-5-6-10-22)33-15-13-32(14-16-33)21-7-3-2-4-8-21/h2-4,7-8,11-12,17-18,22,25H,5-6,9-10,13-16H2,1H3,(H,28,35) ADHPEXKPDZDCGO-UHFFFAOYSA-N 41755 3-[(1-Cyclopentyl-1H-tetrazol-5-yl)-(4-phenyl-piperazin-1-yl)-methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyl-5-tetrazolyl)-(4-phenyl-1-piperazinyl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one::3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazino)methyl]-7-methyl-carbostyril::MLS000071942::SMR000002493::cid_650853 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41755&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 650853 252622476 ZINC19221931 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84384 CCn1c(SCC(N)=O)nnc1-c1ccc(cc1)S(=O)(=O)N1CCN(C)CC1 InChI=1S/C17H24N6O3S2/c1-3-23-16(19-20-17(23)27-12-15(18)24)13-4-6-14(7-5-13)28(25,26)22-10-8-21(2)9-11-22/h4-7H,3,8-12H2,1-2H3,(H2,18,24) ZALDGZDSUBRSKA-UHFFFAOYSA-N 41756 2-[[4-ethyl-5-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide::2-[[4-ethyl-5-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-1,2,4-triazol-3-yl]sulfanyl]ethanamide::2-[[4-ethyl-5-[4-(4-methylpiperazino)sulfonylphenyl]-1,2,4-triazol-3-yl]thio]acetamide::2-[[4-ethyl-5-[4-[(4-methyl-1-piperazinyl)sulfonyl]phenyl]-1,2,4-triazol-3-yl]thio]acetamide::2-{4-Ethyl-5-[4-(4-methyl-piperazine-1-sulfonyl)-phenyl]-4H-[1,2,4]triazol-3-ylsulfanyl}-acetamide::MLS000072580::SMR000002266::cid_651311 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41756&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 651311 252622477 ZINC36296032 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84385 CCC(=O)N1CCN(CC1)c1ccc(NC(=O)c2ccc3OCOc3c2)cc1 InChI=1S/C21H23N3O4/c1-2-20(25)24-11-9-23(10-12-24)17-6-4-16(5-7-17)22-21(26)15-3-8-18-19(13-15)28-14-27-18/h3-8,13H,2,9-12,14H2,1H3,(H,22,26) OHJWZEMHHPSNLZ-UHFFFAOYSA-N 41757 Benzo[1,3]dioxole-5-carboxylic acid [4-(4-propionyl-piperazin-1-yl)-phenyl]-amide::MLS000033956::N-[4-(4-propanoylpiperazin-1-yl)phenyl]-1,3-benzodioxole-5-carboxamide::N-[4-(4-propionylpiperazino)phenyl]-piperonylamide::N-[4-[4-(1-oxopropyl)-1-piperazinyl]phenyl]-1,3-benzodioxole-5-carboxamide::SMR000014586::cid_652011 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41757&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 652011 252622478 ZINC00809572 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84386 CCOC(=O)Cc1csc(NC(=O)CSc2nnc(o2)-c2ccc(F)cc2)n1 InChI=1S/C17H15FN4O4S2/c1-2-25-14(24)7-12-8-27-16(19-12)20-13(23)9-28-17-22-21-15(26-17)10-3-5-11(18)6-4-10/h3-6,8H,2,7,9H2,1H3,(H,19,20,23) QBJGPSUBFYSVCP-UHFFFAOYSA-N 41758 (2-{2-[5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-acetylamino}-thiazol-4-yl)-acetic acid ethyl ester::2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]-1-oxoethyl]amino]-4-thiazolyl]acetic acid ethyl ester::2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]thio]acetyl]amino]thiazol-4-yl]acetic acid ethyl ester::MLS000071801::SMR000003120::cid_653271::ethyl 2-[2-[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanoylamino]-1,3-thiazol-4-yl]ethanoate::ethyl 2-[2-[[2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]amino]-1,3-thiazol-4-yl]acetate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41758&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 653271 252622479 ZINC04375512 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84387 COc1ccc(CC2NCCC3(O)CCCCC23)cc1 InChI=1S/C17H25NO2/c1-20-14-7-5-13(6-8-14)12-16-15-4-2-3-9-17(15,19)10-11-18-16/h5-8,15-16,18-19H,2-4,9-12H2,1H3 PANQQHGRCGEZCM-UHFFFAOYSA-N 41759 1-(4-Methoxy-benzyl)-octahydro-isoquinolin-4a-ol::1-[(4-methoxyphenyl)methyl]-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol::1-p-anisyl-2,3,4,5,6,7,8,8a-octahydro-1H-isoquinolin-4a-ol::MLS000074557::SMR000014065::cid_655005 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41759&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655005 252622480 ZINC04290960 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84388 OC(=O)C1(CCC(=O)C1)c1ccccc1 InChI=1S/C12H12O3/c13-10-6-7-12(8-10,11(14)15)9-4-2-1-3-5-9/h1-5H,6-8H2,(H,14,15) GZFDVSDSPLDDJS-UHFFFAOYSA-N 41760 3-Oxo-1-phenyl-cyclopentanecarboxylic acid::3-keto-1-phenyl-cyclopentanecarboxylic acid::3-oxidanylidene-1-phenyl-cyclopentane-1-carboxylic acid::3-oxo-1-phenyl-1-cyclopentanecarboxylic acid::3-oxo-1-phenylcyclopentane-1-carboxylic acid::MLS000032541::SMR000009429::cid_655176 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41760&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655176 252622481 ZINC00328209 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84389 Cn1c2ncn(CCCc3ccccc3)c2c(=O)n(C)c1=O InChI=1S/C16H18N4O2/c1-18-14-13(15(21)19(2)16(18)22)20(11-17-14)10-6-9-12-7-4-3-5-8-12/h3-5,7-8,11H,6,9-10H2,1-2H3 COZBOOBOYNKJBR-UHFFFAOYSA-N 41761 1,3-Dimethyl-7-(3-phenyl-propyl)-3,7-dihydro-purine-2,6-dione::1,3-dimethyl-7-(3-phenylpropyl)purine-2,6-dione::1,3-dimethyl-7-(3-phenylpropyl)xanthine::MLS000075466::SMR000010660::cid_655558 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41761&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 655558 252622482 ZINC00380557 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84390 CCCSc1nc(N2CCOCC2)c2CCCCc2c1C#N InChI=1S/C17H23N3OS/c1-2-11-22-17-15(12-18)13-5-3-4-6-14(13)16(19-17)20-7-9-21-10-8-20/h2-11H2,1H3 GBLQTUPKPFDZPX-UHFFFAOYSA-N 37310 1-(4-morpholinyl)-3-(propylthio)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::1-morpholin-4-yl-3-propylsulfanyl-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::1-morpholino-3-(propylthio)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile::MLS000071300::SMR000039075::cid_658137 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37310&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 658137 252618281 ZINC20826934 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84391 CC1(C)CC(=O)C=C(C1)NCc1ccncc1 InChI=1S/C14H18N2O/c1-14(2)8-12(7-13(17)9-14)16-10-11-3-5-15-6-4-11/h3-7,16H,8-10H2,1-2H3 CEJRNMJRBUFLIR-UHFFFAOYSA-N 41762 5,5-dimethyl-3-(4-pyridylmethylamino)cyclohex-2-en-1-one::5,5-dimethyl-3-(pyridin-4-ylmethylamino)-1-cyclohex-2-enone::5,5-dimethyl-3-(pyridin-4-ylmethylamino)cyclohex-2-en-1-one::MLS000038448::SMR000036470::cid_658329 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41762&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 658329 252622483 ZINC04083056 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84392 Cc1ccc(cc1)-n1c(O)c(C=NCCN2CCOCC2)c(=O)[nH]c1=O InChI=1S/C18H22N4O4/c1-13-2-4-14(5-3-13)22-17(24)15(16(23)20-18(22)25)12-19-6-7-21-8-10-26-11-9-21/h2-5,12,24H,6-11H2,1H3,(H,20,23,25) KJUSUBNBSAGLQB-UHFFFAOYSA-N 41763 (5E)-1-(4-methylphenyl)-5-[(2-morpholin-4-ylethylamino)methylidene]-1,3-diazinane-2,4,6-trione::(5E)-1-(4-methylphenyl)-5-[[2-(4-morpholinyl)ethylamino]methylidene]-1,3-diazinane-2,4,6-trione::(5E)-5-[(2-morpholinoethylamino)methylene]-1-(p-tolyl)barbituric acid::MLS000036795::SMR000040602::cid_5389133 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41763&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5389133 252622484 ZINC19994468 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84393 COC(=O)CCc1c(C)[nH]c(=S)[nH]c1=O InChI=1S/C9H12N2O3S/c1-5-6(3-4-7(12)14-2)8(13)11-9(15)10-5/h3-4H2,1-2H3,(H2,10,11,13,15) ISRRLTIEWOHRNX-UHFFFAOYSA-N 41764 3-(4-keto-6-methyl-2-thioxo-1H-pyrimidin-5-yl)propionic acid methyl ester::3-(6-methyl-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanoic acid methyl ester::MLS000077573::SMR000034647::cid_660631::methyl 3-(6-methyl-4-oxidanylidene-2-sulfanylidene-1H-pyrimidin-5-yl)propanoate::methyl 3-(6-methyl-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)propanoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41764&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 660631 252622485 ZINC17887074 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84394 CCOC(=O)c1ccc(NC(=O)c2c(O)[nH]c(=O)[nH]c2=O)cc1 InChI=1S/C14H13N3O6/c1-2-23-13(21)7-3-5-8(6-4-7)15-10(18)9-11(19)16-14(22)17-12(9)20/h3-6H,2H2,1H3,(H,15,18)(H3,16,17,19,20,22) XWZUFKMEGYKBSH-UHFFFAOYSA-N 41765 4-[(6-hydroxy-2,4-diketo-1H-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::4-[[(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid ethyl ester::MLS000040367::SMR000058126::cid_662817::ethyl 4-[(6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carbonyl)amino]benzoate::ethyl 4-[[6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41765&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 662817 252622486 ZINC06499020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84395 FC(F)(F)C1(NC(=O)c2ccco2)NC(=O)N(CC2CCCCC2)C1=O InChI=1S/C16H18F3N3O4/c17-16(18,19)15(20-12(23)11-7-4-8-26-11)13(24)22(14(25)21-15)9-10-5-2-1-3-6-10/h4,7-8,10H,1-3,5-6,9H2,(H,20,23)(H,21,25) VOKFQDFDAZVPOY-UHFFFAOYSA-N 41766 MLS000040678::N-[1-(cyclohexylmethyl)-2,5-bis(oxidanylidene)-4-(trifluoromethyl)imidazolidin-4-yl]furan-2-carboxamide::N-[1-(cyclohexylmethyl)-2,5-diketo-4-(trifluoromethyl)imidazolidin-4-yl]-2-furamide::N-[1-(cyclohexylmethyl)-2,5-dioxo-4-(trifluoromethyl)-4-imidazolidinyl]-2-furancarboxamide::N-[1-(cyclohexylmethyl)-2,5-dioxo-4-(trifluoromethyl)imidazolidin-4-yl]furan-2-carboxamide::SMR000044833::cid_663976 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41766&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 663976 252622487 ZINC02420569 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84396 O=C(CN1C(=O)c2ccccc2C1=O)N1CCN(CC1)c1nnc(-c2ccccc2)c2ccccc12 InChI=1S/C28H23N5O3/c34-24(18-33-27(35)22-12-6-7-13-23(22)28(33)36)31-14-16-32(17-15-31)26-21-11-5-4-10-20(21)25(29-30-26)19-8-2-1-3-9-19/h1-13H,14-18H2 IXQKLGBUUZVOSE-UHFFFAOYSA-N 41767 2-[2-keto-2-[4-(4-phenylphthalazin-1-yl)piperazino]ethyl]isoindoline-1,3-quinone::2-[2-oxidanylidene-2-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]ethyl]isoindole-1,3-dione::2-[2-oxo-2-[4-(4-phenyl-1-phthalazinyl)-1-piperazinyl]ethyl]isoindole-1,3-dione::2-[2-oxo-2-[4-(4-phenylphthalazin-1-yl)piperazin-1-yl]ethyl]isoindole-1,3-dione::MLS000080299::SMR000035392::cid_664563 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41767&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 664563 252622488 ZINC02393309 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84397 CC(C)N(Cc1cc2ccccc2[nH]c1=O)C(=O)c1cccnc1 InChI=1S/C19H19N3O2/c1-13(2)22(19(24)15-7-5-9-20-11-15)12-16-10-14-6-3-4-8-17(14)21-18(16)23/h3-11,13H,12H2,1-2H3,(H,21,23) YRUNVDQFBNTJJU-UHFFFAOYSA-N 41768 MLS000040805::N-[(2-oxidanylidene-1H-quinolin-3-yl)methyl]-N-propan-2-yl-pyridine-3-carboxamide::N-[(2-oxo-1H-quinolin-3-yl)methyl]-N-propan-2-yl-3-pyridinecarboxamide::N-[(2-oxo-1H-quinolin-3-yl)methyl]-N-propan-2-ylpyridine-3-carboxamide::N-isopropyl-N-[(2-keto-1H-quinolin-3-yl)methyl]nicotinamide::SMR000045745::cid_664836 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41768&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 664836 252622489 ZINC08619780 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84398 CN1CC2(Cc3cc(C)ccc13)C(=O)NC(=O)N(C2=O)c1ccccc1C InChI=1S/C21H21N3O3/c1-13-8-9-17-15(10-13)11-21(12-23(17)3)18(25)22-20(27)24(19(21)26)16-7-5-4-6-14(16)2/h4-10H,11-12H2,1-3H3,(H,22,25,27) PWOCMFZIMZKXHI-UHFFFAOYSA-N 41769 1',6'-dimethyl-1-(2-methylphenyl)spiro[1,3-diazinane-5,3'-2,4-dihydroquinoline]-2,4,6-trione::1,6-dimethyl-1'-(o-tolyl)spiro[2,4-dihydroquinoline-3,5'-hexahydropyrimidine]-2',4',6'-trione::MLS000042257::SMR000047525::cid_666205 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41769&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 666205 252622490 ZINC09087711 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84399 CN1C(=O)N(C)C(=O)C2(Sc3ccccc3C2=O)C1=O InChI=1S/C13H10N2O4S/c1-14-10(17)13(11(18)15(2)12(14)19)9(16)7-5-3-4-6-8(7)20-13/h3-6H,1-2H3 AOJMVFZSESQXSW-UHFFFAOYSA-N 41770 1',3'-dimethylspiro[benzothiophene-2,5'-hexahydropyrimidine]-2',3,4',6'-diquinone::1,3-dimethylspiro[1,3-diazinane-5,2'-1-benzothiophene]-2,3',4,6-tetrone::MLS000055669::SMR000060674::cid_2324605 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41770&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2324605 252622491 ZINC03199325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84400 C(Nc1ccccc1)c1nnc2CCCCCn12 InChI=1S/C14H18N4/c1-3-7-12(8-4-1)15-11-14-17-16-13-9-5-2-6-10-18(13)14/h1,3-4,7-8,15H,2,5-6,9-11H2 OOJNELXWRKRYSI-UHFFFAOYSA-N 41771 MLS000057041::N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylmethyl)aniline::SMR000060400::cid_2310790::phenyl(6,7,8,9-tetrahydro-5H-[1,2,4]triazol[4,3-a]azepin-3-ylmethyl)amine Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41771&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2310790 252622492 ZINC03171849 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84401 CCNC(=O)NC(=O)C(C)OC(=O)c1cccnc1SC InChI=1S/C13H17N3O4S/c1-4-14-13(19)16-10(17)8(2)20-12(18)9-6-5-7-15-11(9)21-3/h5-8H,4H2,1-3H3,(H2,14,16,17,19) MODWYEMRBXFKPQ-UHFFFAOYSA-N 41772 2-(methylthio)-3-pyridinecarboxylic acid [1-(ethylcarbamoylamino)-1-oxopropan-2-yl] ester::2-(methylthio)nicotinic acid [2-(ethylcarbamoylamino)-2-keto-1-methyl-ethyl] ester::MLS000053625::SMR000066587::[1-(ethylcarbamoylamino)-1-oxidanylidene-propan-2-yl] 2-methylsulfanylpyridine-3-carboxylate::[1-(ethylcarbamoylamino)-1-oxopropan-2-yl] 2-methylsulfanylpyridine-3-carboxylate::cid_2998051 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41772&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2998051 252622493 ZINC02640951 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84402 OC(=O)c1ccc(CNC(=O)CN2C(=O)COc3ccccc23)cc1 InChI=1S/C18H16N2O5/c21-16(19-9-12-5-7-13(8-6-12)18(23)24)10-20-14-3-1-2-4-15(14)25-11-17(20)22/h1-8H,9-11H2,(H,19,21)(H,23,24) BXGZDQAFFSEREH-UHFFFAOYSA-N 41773 4-[[2-(3-oxidanylidene-1,4-benzoxazin-4-yl)ethanoylamino]methyl]benzoic acid::4-[[[1-oxo-2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]amino]methyl]benzoic acid::4-[[[2-(3-keto-1,4-benzoxazin-4-yl)acetyl]amino]methyl]benzoic acid::4-[[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]methyl]benzoic acid::MLS000056601::SMR000064585::cid_2526829 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41773&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2526829 252622494 ZINC03407963 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84403 Brc1ccc(s1)S(=O)(=O)NCC(=O)N1CCCC1 InChI=1S/C10H13BrN2O3S2/c11-8-3-4-10(17-8)18(15,16)12-7-9(14)13-5-1-2-6-13/h3-4,12H,1-2,5-7H2 YFADDZBVQYUEMH-UHFFFAOYSA-N 41774 5-bromanyl-N-(2-oxidanylidene-2-pyrrolidin-1-yl-ethyl)thiophene-2-sulfonamide::5-bromo-N-(2-keto-2-pyrrolidino-ethyl)thiophene-2-sulfonamide::5-bromo-N-(2-oxo-2-pyrrolidin-1-ylethyl)thiophene-2-sulfonamide::5-bromo-N-[2-oxo-2-(1-pyrrolidinyl)ethyl]-2-thiophenesulfonamide::MLS000090539::SMR000025143::cid_3237147 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41774&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3237147 252622495 ZINC02602308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84404 OC1(NC(=O)c2ccccc2)C(=O)c2ccccc2C1=O InChI=1S/C16H11NO4/c18-13-11-8-4-5-9-12(11)14(19)16(13,21)17-15(20)10-6-2-1-3-7-10/h1-9,21H,(H,17,20) FICSYWUBABJDHB-UHFFFAOYSA-N 32085 MLS000085603::N-(2-hydroxy-1,3-diketo-indan-2-yl)benzamide::N-(2-hydroxy-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)benzamide::N-(2-hydroxy-1,3-dioxo-2-indenyl)benzamide::N-(2-hydroxy-1,3-dioxoinden-2-yl)benzamide::N-[2-oxidanyl-1,3-bis(oxidanylidene)inden-2-yl]benzamide::SMR000020538::cid_3237318 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3237318 252615537 ZINC03647975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84405 CC(C(=O)N1CCCCC1)n1nc(C)c2sc3ccccc3c2c1=O InChI=1S/C19H21N3O2S/c1-12-17-16(14-8-4-5-9-15(14)25-17)19(24)22(20-12)13(2)18(23)21-10-6-3-7-11-21/h4-5,8-9,13H,3,6-7,10-11H2,1-2H3 DOTOMXRXJJNUOG-UHFFFAOYSA-N 35390 2-(2-keto-1-methyl-2-piperidino-ethyl)-4-methyl-benzothiopheno[2,3-d]pyridazin-1-one::4-methyl-2-(1-methyl-2-oxo-2-piperidin-1-ylethyl)[1]benzothieno[2,3-d]pyridazin-1(2H)-one::4-methyl-2-(1-oxidanylidene-1-piperidin-1-yl-propan-2-yl)-[1]benzothiolo[2,3-d]pyridazin-1-one::4-methyl-2-(1-oxo-1-piperidin-1-ylpropan-2-yl)-[1]benzothiolo[2,3-d]pyridazin-1-one::4-methyl-2-[1-oxo-1-(1-piperidinyl)propan-2-yl]-[1]benzothiolo[2,3-d]pyridazin-1-one::MLS000093662::SMR000029280::cid_3238280 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35390&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3238280 252617659 ZINC04103920 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84406 CCn1ccc(n1)C(=O)Nc1ccc(cc1)N(C)C(C)=O InChI=1S/C15H18N4O2/c1-4-19-10-9-14(17-19)15(21)16-12-5-7-13(8-6-12)18(3)11(2)20/h5-10H,4H2,1-3H3,(H,16,21) ITHLLNAEGXABNZ-UHFFFAOYSA-N 41775 MLS000043435::N-[4-[acetyl(methyl)amino]phenyl]-1-ethyl-3-pyrazolecarboxamide::N-[4-[acetyl(methyl)amino]phenyl]-1-ethyl-pyrazole-3-carboxamide::N-[4-[acetyl(methyl)amino]phenyl]-1-ethylpyrazole-3-carboxamide::N-[4-[ethanoyl(methyl)amino]phenyl]-1-ethyl-pyrazole-3-carboxamide::N-{4-[acetyl(methyl)amino]phenyl}-1-ethyl-1H-pyrazole-3-carboxamide::SMR000020252::cid_3238912 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41775&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3238912 252622496 ZINC00205154 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84407 O=C1CCn2cnc3cccc4ccc1c2c34 InChI=1S/C14H10N2O/c17-12-6-7-16-8-15-11-3-1-2-9-4-5-10(12)14(16)13(9)11/h1-5,8H,6-7H2 HBIWCEFNSGRROL-UHFFFAOYSA-N 34608 7,8-dihydro-9H-pyrido[1,2,3-cd]perimidin-9-one::MLS000044006::SMR000021417::cid_677487 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34608&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 677487 242052897 ZINC00041157 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84408 CCn1cnc2sc(C(=O)N3CCN(CC3)c3ccc(OC)cc3)c(C)c2c1=O InChI=1S/C21H24N4O3S/c1-4-23-13-22-19-17(20(23)26)14(2)18(29-19)21(27)25-11-9-24(10-12-25)15-5-7-16(28-3)8-6-15/h5-8,13H,4,9-12H2,1-3H3 OUTGETYLJYFRDG-UHFFFAOYSA-N 41776 3-ethyl-6-[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl-5-methyl-thieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methyl-thieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methylthieno[2,3-d]pyrimidin-4-one::3-ethyl-6-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]-5-methyl-4-thieno[2,3-d]pyrimidinone::3-ethyl-6-{[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl}-5-methylthieno[2,3-d]pyrimidin-4(3H)-one::MLS000089815::SMR000024433::cid_3241114 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41776&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3241114 252622497 ZINC04056947 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84409 O=C(Nc1ccccn1)C1CCN(CC1)S(=O)(=O)c1cccc2nonc12 InChI=1S/C17H17N5O4S/c23-17(19-15-6-1-2-9-18-15)12-7-10-22(11-8-12)27(24,25)14-5-3-4-13-16(14)21-26-20-13/h1-6,9,12H,7-8,10-11H2,(H,18,19,23) PZMQVMXXJJCIDZ-UHFFFAOYSA-N 41777 1-(2,1,3-benzoxadiazol-4-ylsulfonyl)-N-(2-pyridinyl)-4-piperidinecarboxamide::1-(2,1,3-benzoxadiazol-4-ylsulfonyl)-N-pyridin-2-yl-piperidine-4-carboxamide::1-(2,1,3-benzoxadiazol-4-ylsulfonyl)-N-pyridin-2-ylpiperidine-4-carboxamide::1-benzofurazan-4-ylsulfonyl-N-(2-pyridyl)isonipecotamide::MLS000090584::SMR000025188::cid_3241494 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41777&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3241494 252622498 ZINC02467659 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84410 NC(=O)C1(CCN(CC1)C(=O)NC1CCCCC1)N1CCCCC1 InChI=1S/C18H32N4O2/c19-16(23)18(22-11-5-2-6-12-22)9-13-21(14-10-18)17(24)20-15-7-3-1-4-8-15/h15H,1-14H2,(H2,19,23)(H,20,24) LNEFWEVPXMONGI-UHFFFAOYSA-N 41778 1-N-cyclohexyl-4-piperidin-1-ylpiperidine-1,4-dicarboxamide::MLS000094250::N-cyclohexyl-4-piperidino-piperidine-1,4-dicarboxamide::N1-cyclohexyl-4-(1-piperidinyl)piperidine-1,4-dicarboxamide::N1-cyclohexyl-4-piperidin-1-yl-piperidine-1,4-dicarboxamide::N~1~'-cyclohexyl-1,4'-bipiperidine-1',4'-dicarboxamide::SMR000029840::cid_3242636 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41778&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3242636 252622499 ZINC04077168 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84411 CC(=O)N1CCc2cc(Br)cc(c12)S(=O)(=O)NCc1ccccn1 InChI=1S/C16H16BrN3O3S/c1-11(21)20-7-5-12-8-13(17)9-15(16(12)20)24(22,23)19-10-14-4-2-3-6-18-14/h2-4,6,8-9,19H,5,7,10H2,1H3 WARNLUCAHADWDF-UHFFFAOYSA-N 41779 1-acetyl-5-bromo-N-(2-pyridinylmethyl)-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-(2-pyridylmethyl)indoline-7-sulfonamide::1-acetyl-5-bromo-N-(pyridin-2-ylmethyl)-2,3-dihydroindole-7-sulfonamide::1-acetyl-5-bromo-N-(pyridin-2-ylmethyl)indoline-7-sulfonamide::5-bromanyl-1-ethanoyl-N-(pyridin-2-ylmethyl)-2,3-dihydroindole-7-sulfonamide::MLS000086257::SMR000021766::cid_3242806 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41779&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3242806 252622500 ZINC02456155 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84412 CC(C)OCCCNC(=O)c1ccc(NC(=O)C2CCCO2)cc1 InChI=1S/C18H26N2O4/c1-13(2)23-12-4-10-19-17(21)14-6-8-15(9-7-14)20-18(22)16-5-3-11-24-16/h6-9,13,16H,3-5,10-12H2,1-2H3,(H,19,21)(H,20,22) NNNDGXJQBMEKOL-UHFFFAOYSA-N 41780 MLS000086701::N-(4-{[(3-isopropoxypropyl)amino]carbonyl}phenyl)tetrahydrofuran-2-carboxamide::N-[4-(3-isopropoxypropylcarbamoyl)phenyl]tetrahydrofuran-2-carboxamide::N-[4-(3-propan-2-yloxypropylcarbamoyl)phenyl]oxolane-2-carboxamide::N-[4-[oxo-(3-propan-2-yloxypropylamino)methyl]phenyl]-2-oxolanecarboxamide::SMR000022741::cid_3244061 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41780&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3244061 252622501 ZINC03906325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84413 Cc1ccc(Cl)cc1N1CCN(CC1)S(=O)(=O)c1ccc2n(C)c(=O)oc2c1 InChI=1S/C19H20ClN3O4S/c1-13-3-4-14(20)11-17(13)22-7-9-23(10-8-22)28(25,26)15-5-6-16-18(12-15)27-19(24)21(16)2/h3-6,11-12H,7-10H2,1-2H3 CPYIYHOKMIZHAD-UHFFFAOYSA-N 41781 6-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[4-(5-chloro-2-methyl-phenyl)piperazino]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl-3-methyl-1,3-benzoxazol-2-one::6-[[4-(5-chloro-2-methylphenyl)-1-piperazinyl]sulfonyl]-3-methyl-1,3-benzoxazol-2-one::6-{[4-(5-chloro-2-methylphenyl)piperazin-1-yl]sulfonyl}-3-methyl-1,3-benzoxazol-2(3H)-one::MLS000092349::SMR000027426::cid_2983872 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41781&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2983872 252622502 ZINC04058144 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84414 CCC(Sc1nc2nnc(C)c2c(N)n1-c1cccc(Cl)c1)C(=O)NCCOC InChI=1S/C19H23ClN6O2S/c1-4-14(18(27)22-8-9-28-3)29-19-23-17-15(11(2)24-25-17)16(21)26(19)13-7-5-6-12(20)10-13/h5-7,10,14H,4,8-9,21H2,1-3H3,(H,22,27) LXNUZWHEMOKYNJ-UHFFFAOYSA-N 41782 2-[4-amino-5-(3-chlorophenyl)-3-methylpyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl-N-(2-methoxyethyl)butanamide::2-[4-azanyl-5-(3-chlorophenyl)-3-methyl-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl-N-(2-methoxyethyl)butanamide::2-[[4-amino-5-(3-chlorophenyl)-3-methyl-6-pyrazolo[3,4-d]pyrimidinyl]thio]-N-(2-methoxyethyl)butanamide::2-[[4-amino-5-(3-chlorophenyl)-3-methyl-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-N-(2-methoxyethyl)butyramide::2-{[5-(3-chlorophenyl)-4-imino-3-methyl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio}-N-(2-methoxyethyl)butanamide::MLS000047108::SMR000033119::cid_3245367 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41782&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3245367 252622503 ZINC49539778 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84415 CC1Cn2c(S1)nnc2-c1cc2ccccc2cc1O InChI=1S/C15H13N3OS/c1-9-8-18-14(16-17-15(18)20-9)12-6-10-4-2-3-5-11(10)7-13(12)19/h2-7,9,19H,8H2,1H3 QTSVSHZDVQRJCV-UHFFFAOYSA-N 41783 (3E)-3-(6-methyl-5,6-dihydro-2H-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-ylidene)naphthalen-2-one::(3E)-3-(6-methyl-5,6-dihydro-2H-thiazolo[2,3-c][1,2,4]triazol-3-ylidene)-2-naphthalenone::(3E)-3-(6-methyl-5,6-dihydro-2H-thiazolo[2,3-c][1,2,4]triazol-3-ylidene)naphthalen-2-one::3-(6-methyl-5,6-dihydro[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl)-2-naphthol::MLS000066435::SMR000081402::cid_5771713 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41783&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5771713 252622504 ZINC12467700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84416 Cc1nn2c(ncc(NC(=O)c3ccc(C)cc3)c2=O)s1 InChI=1S/C14H12N4O2S/c1-8-3-5-10(6-4-8)12(19)16-11-7-15-14-18(13(11)20)17-9(2)21-14/h3-7H,1-2H3,(H,16,19) MLXGFKLTQYTDMA-UHFFFAOYSA-N 41784 4-methyl-N-(2-methyl-5-oxidanylidene-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::4-methyl-N-(2-methyl-5-oxo-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::4-methyl-N-(2-methyl-5-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)benzamide::MLS000100118::N-(5-keto-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-yl)-4-methyl-benzamide::SMR000081907::cid_2233157 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41784&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2233157 252622505 ZINC02880962 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84417 CC(C)=CC(=O)NCCc1ccccc1 InChI=1S/C13H17NO/c1-11(2)10-13(15)14-9-8-12-6-4-3-5-7-12/h3-7,10H,8-9H2,1-2H3,(H,14,15) FCKSARQRQMJRHX-UHFFFAOYSA-N 41785 3-methyl-N-(2-phenylethyl)-2-butenamide::3-methyl-N-(2-phenylethyl)but-2-enamide::3-methyl-N-phenethyl-but-2-enamide::MLS000089152::SMR000072849::cid_731815 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41785&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 731815 252622506 ZINC00145632 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84418 Cc1ccccc1NS(=O)(=O)c1cc(ccc1C)C(=O)NCc1ccco1 InChI=1S/C20H20N2O4S/c1-14-6-3-4-8-18(14)22-27(24,25)19-12-16(10-9-15(19)2)20(23)21-13-17-7-5-11-26-17/h3-12,22H,13H2,1-2H3,(H,21,23) YRQJWUOJVVUYMP-UHFFFAOYSA-N 41786 MLS000052108::N-(2-furanylmethyl)-4-methyl-3-[(2-methylphenyl)sulfamoyl]benzamide::N-(2-furfuryl)-4-methyl-3-(o-tolylsulfamoyl)benzamide::N-(2-furylmethyl)-4-methyl-3-{[(2-methylphenyl)amino]sulfonyl}benzamide::N-(furan-2-ylmethyl)-4-methyl-3-[(2-methylphenyl)sulfamoyl]benzamide::SMR000081430::cid_1251601 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41786&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1251601 252622507 ZINC01061586 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84419 CCOC(=O)c1cc2C(=O)c3ccccc3-n2c1N InChI=1S/C14H12N2O3/c1-2-19-14(18)9-7-11-12(17)8-5-3-4-6-10(8)16(11)13(9)15/h3-7H,2,15H2,1H3 NLOFNKPOURZRLR-UHFFFAOYSA-N 41787 1-amino-4-keto-pyrrol[1,2-a]indole-2-carboxylic acid ethyl ester::1-amino-4-oxo-2-pyrrolo[1,2-a]indolecarboxylic acid ethyl ester::MLS000058819::SMR000069085::cid_611015::ethyl 1-amino-4-oxopyrrolo[1,2-a]indole-2-carboxylate::ethyl 1-azanyl-4-oxidanylidene-pyrrolo[1,2-a]indole-2-carboxylate::ethyl 3-amino-9-oxo-9H-pyrrolo[1,2-a]indole-2-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41787&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 611015 252622508 ZINC00285539 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84420 C\C(=C/C(=O)Nc1cc(C)on1)c1ccccc1 InChI=1S/C14H14N2O2/c1-10(12-6-4-3-5-7-12)8-14(17)15-13-9-11(2)18-16-13/h3-9H,1-2H3,(H,15,16,17)/b10-8+ PEFNMKYDZNYGDS-CSKARUKUSA-N 41788 (E)-N-(5-methyl-1,2-oxazol-3-yl)-3-phenyl-but-2-enamide::(E)-N-(5-methyl-1,2-oxazol-3-yl)-3-phenylbut-2-enamide::(E)-N-(5-methyl-3-isoxazolyl)-3-phenyl-2-butenamide::(E)-N-(5-methylisoxazol-3-yl)-3-phenyl-but-2-enamide::MLS000089139::SMR000072835::cid_891479 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41788&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 891479 252622509 ZINC00467035 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84421 CCc1nc2cc(Cl)c(Cl)cc2[nH]1 InChI=1S/C9H8Cl2N2/c1-2-9-12-7-3-5(10)6(11)4-8(7)13-9/h3-4H,2H2,1H3,(H,12,13) TUAVLJUMDKFUGC-UHFFFAOYSA-N 41789 5,6-bis(chloranyl)-2-ethyl-1H-benzimidazole::5,6-dichloro-2-ethyl-1H-benzimidazole::MLS000064722::SMR000077529::cid_972654 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41789&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 972654 252622510 ZINC00612976 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84422 COc1ccc(cc1)S(=O)(=O)N(C)CC(=O)Nc1ccccc1C(F)(F)F InChI=1S/C17H17F3N2O4S/c1-22(27(24,25)13-9-7-12(26-2)8-10-13)11-16(23)21-15-6-4-3-5-14(15)17(18,19)20/h3-10H,11H2,1-2H3,(H,21,23) SCASZLCSYABLPV-UHFFFAOYSA-N 41790 2-[(4-methoxyphenyl)sulfonyl-methyl-amino]-N-[2-(trifluoromethyl)phenyl]acetamide::2-[(4-methoxyphenyl)sulfonyl-methyl-amino]-N-[2-(trifluoromethyl)phenyl]ethanamide::2-[(4-methoxyphenyl)sulfonyl-methylamino]-N-[2-(trifluoromethyl)phenyl]acetamide::MLS000096640::N~2~-[(4-methoxyphenyl)sulfonyl]-N~2~-methyl-N~1~-[2-(trifluoromethyl)phenyl]glycinamide::SMR000073810::cid_1318352 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41790&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1318352 252622511 ZINC01146983 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84423 COC(=O)CNC(=O)C12CC3(C)CC(C)(CC(C)(C3)C1)C2 InChI=1S/C17H27NO3/c1-14-6-15(2)8-16(3,7-14)11-17(9-14,10-15)13(20)18-5-12(19)21-4/h5-11H2,1-4H3,(H,18,20) YMIFHWGGNONKNU-UHFFFAOYSA-N 41791 2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetic acid methyl ester::2-[[oxo-(3,5,7-trimethyl-1-adamantyl)methyl]amino]acetic acid methyl ester::MLS000099463::SMR000074065::cid_2944994::methyl 2-[(3,5,7-trimethyl-1-adamantyl)carbonylamino]ethanoate::methyl 2-[(3,5,7-trimethyladamantane-1-carbonyl)amino]acetate::methyl N-[(3,5,7-trimethyl-1-adamantyl)carbonyl]glycinate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41791&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2944994 252622512 ZINC04197139 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84424 C=CCn1c2ccccc2c2nnc(SCc3ccc4nonc4c3)nc12 InChI=1S/C19H14N6OS/c1-2-9-25-16-6-4-3-5-13(16)17-18(25)20-19(22-21-17)27-11-12-7-8-14-15(10-12)24-26-23-14/h2-8,10H,1,9,11H2 CBDVEMJKSUSVCA-UHFFFAOYSA-N 41792 5-[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanylmethyl]-2,1,3-benzoxadiazole::5-[[(5-allyl-[1,2,4]triazin[5,6-b]indol-3-yl)thio]methyl]benzofurazan::5-[[(5-prop-2-enyl-[1,2,4]triazino[5,6-b]indol-3-yl)thio]methyl]-2,1,3-benzoxadiazole::5-allyl-3-[(2,1,3-benzoxadiazol-5-ylmethyl)thio]-5H-[1,2,4]triazino[5,6-b]indole::MLS000050812::SMR000078439::cid_2963029 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41792&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2963029 252622513 ZINC00719220 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84425 COc1cccc(OC)c1C(=O)N1CCN(CC1)c1ccccn1 InChI=1S/C18H21N3O3/c1-23-14-6-5-7-15(24-2)17(14)18(22)21-12-10-20(11-13-21)16-8-3-4-9-19-16/h3-9H,10-13H2,1-2H3 SFCMHKMQHYHCNL-UHFFFAOYSA-N 41793 (2,6-dimethoxyphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone::(2,6-dimethoxyphenyl)-[4-(2-pyridinyl)-1-piperazinyl]methanone::(2,6-dimethoxyphenyl)-[4-(2-pyridyl)piperazino]methanone::1-(2,6-dimethoxybenzoyl)-4-(2-pyridinyl)piperazine::MLS000064408::SMR000078044::cid_973595 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41793&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 973595 252622514 ZINC04272463 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84426 Brc1ccc(cc1)N1CC(=O)N(CC(=O)N2CCCc3ccccc23)C1=O InChI=1S/C20H18BrN3O3/c21-15-7-9-16(10-8-15)23-12-19(26)24(20(23)27)13-18(25)22-11-3-5-14-4-1-2-6-17(14)22/h1-2,4,6-10H,3,5,11-13H2 GWERRMPVBJOLKR-UHFFFAOYSA-N 41794 1-(4-bromophenyl)-3-[2-(3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]-2,4-imidazolidinedione::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-keto-ethyl]hydantoin::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxidanylidene-ethyl]imidazolidine-2,4-dione::1-(4-bromophenyl)-3-[2-(3,4-dihydro-2H-quinolin-1-yl)-2-oxoethyl]imidazolidine-2,4-dione::MLS000051992::SMR000081238::cid_2228525 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41794&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2228525 252622515 ZINC02876136 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84427 COC(=O)c1cc(NC(=O)C2CCCO2)cc(c1)C(=O)OC InChI=1S/C15H17NO6/c1-20-14(18)9-6-10(15(19)21-2)8-11(7-9)16-13(17)12-4-3-5-22-12/h6-8,12H,3-5H2,1-2H3,(H,16,17) PFCZCPVSHGSOQJ-UHFFFAOYSA-N 41795 5-(tetrahydrofuran-2-carbonylamino)benzene-1,3-dicarboxylic acid dimethyl ester::5-[[oxo(2-oxolanyl)methyl]amino]benzene-1,3-dicarboxylic acid dimethyl ester::MLS000088767::SMR000071907::cid_2932403::dimethyl 5-(oxolan-2-ylcarbonylamino)benzene-1,3-dicarboxylate::dimethyl 5-(oxolane-2-carbonylamino)benzene-1,3-dicarboxylate::dimethyl 5-[(tetrahydro-2-furanylcarbonyl)amino]isophthalate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41795&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2932403 252622516 ZINC00475707 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84428 CCOCCCNC(=O)CCCOc1ccccc1 InChI=1S/C15H23NO3/c1-2-18-12-7-11-16-15(17)10-6-13-19-14-8-4-3-5-9-14/h3-5,8-9H,2,6-7,10-13H2,1H3,(H,16,17) OAJDPKICLPKFMF-UHFFFAOYSA-N 41796 MLS000088375::N-(3-ethoxypropyl)-4-phenoxy-butanamide::N-(3-ethoxypropyl)-4-phenoxy-butyramide::N-(3-ethoxypropyl)-4-phenoxybutanamide::SMR000071739::cid_2179064 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41796&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2179064 252622517 ZINC02818924 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84429 O=c1[nH]cc(COCc2ccccc2)c(=O)[nH]1 InChI=1S/C12H12N2O3/c15-11-10(6-13-12(16)14-11)8-17-7-9-4-2-1-3-5-9/h1-6H,7-8H2,(H2,13,14,15,16) QDNLNNAXVJQLJO-UHFFFAOYSA-N 41797 5-(benzoxymethyl)uracil::5-(phenylmethoxymethyl)-1H-pyrimidine-2,4-dione::5-[(benzyloxy)methyl]-2,4(1H,3H)-pyrimidinedione::MLS000061082::SMR000069595::cid_309850 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41797&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 309850 252622518 ZINC00051670 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84430 Cc1cc(C)n(n1)-c1nnc2SCC(=Nn12)c1ccccc1 InChI=1S/C15H14N6S/c1-10-8-11(2)20(18-10)14-16-17-15-21(14)19-13(9-22-15)12-6-4-3-5-7-12/h3-8H,9H2,1-2H3 KXZFAXRVIUAZFK-UHFFFAOYSA-N 41798 3-(3,5-dimethyl-1-pyrazolyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::3-(3,5-dimethylpyrazol-1-yl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine::MLS000063441::SMR000072098::cid_887538 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41798&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 887538 252622519 ZINC00461052 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84431 CCn1ncc(CN2CCN(CC2)C(=O)Nc2ccccc2C(=O)OC)c1C InChI=1S/C20H27N5O3/c1-4-25-15(2)16(13-21-25)14-23-9-11-24(12-10-23)20(27)22-18-8-6-5-7-17(18)19(26)28-3/h5-8,13H,4,9-12,14H2,1-3H3,(H,22,27) DDAPFCDOCILUNS-UHFFFAOYSA-N 41799 2-[[4-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]piperazine-1-carbonyl]amino]benzoic acid methyl ester::2-[[[4-[(1-ethyl-5-methyl-4-pyrazolyl)methyl]-1-piperazinyl]-oxomethyl]amino]benzoic acid methyl ester::MLS000097106::SMR000076600::cid_2206454::methyl 2-[({4-[(1-ethyl-5-methyl-1H-pyrazol-4-yl)methyl]-1-piperazinyl}carbonyl)amino]benzoate::methyl 2-[[4-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]piperazin-1-yl]carbonylamino]benzoate::methyl 2-[[4-[(1-ethyl-5-methylpyrazol-4-yl)methyl]piperazine-1-carbonyl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41799&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2206454 252622520 ZINC22558024 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84432 CC1Cc2ccccc2N1C(=O)c1ccc2n(C)nnc2c1 InChI=1S/C17H16N4O/c1-11-9-12-5-3-4-6-15(12)21(11)17(22)13-7-8-16-14(10-13)18-19-20(16)2/h3-8,10-11H,9H2,1-2H3 LBTDPRQVAPEDGK-UHFFFAOYSA-N 41800 (1-methyl-5-benzotriazolyl)-(2-methyl-2,3-dihydroindol-1-yl)methanone::(1-methylbenzotriazol-5-yl)-(2-methyl-2,3-dihydroindol-1-yl)methanone::(1-methylbenzotriazol-5-yl)-(2-methylindolin-1-yl)methanone::1-methyl-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)carbonyl]-1H-1,2,3-benzotriazole::MLS000063757::SMR000075546::cid_2950653 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41800&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2950653 252622521 ZINC00619278 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84433 CCc1noc(C)c1C(=O)N1CCOCC1 InChI=1S/C11H16N2O3/c1-3-9-10(8(2)16-12-9)11(14)13-4-6-15-7-5-13/h3-7H2,1-2H3 XPRQQOUFQFNJLI-UHFFFAOYSA-N 41801 (3-ethyl-5-methyl-1,2-oxazol-4-yl)-morpholin-4-yl-methanone::(3-ethyl-5-methyl-1,2-oxazol-4-yl)-morpholin-4-ylmethanone::(3-ethyl-5-methyl-4-isoxazolyl)-(4-morpholinyl)methanone::(3-ethyl-5-methyl-isoxazol-4-yl)-morpholino-methanone::4-[(3-ethyl-5-methyl-4-isoxazolyl)carbonyl]morpholine::MLS000065678::SMR000080331::cid_1245299 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41801&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1245299 252622522 ZINC01053681 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84434 NC(=O)Cn1c(nc2ccccc12)S(=O)(=O)Cc1ccccc1 InChI=1S/C16H15N3O3S/c17-15(20)10-19-14-9-5-4-8-13(14)18-16(19)23(21,22)11-12-6-2-1-3-7-12/h1-9H,10-11H2,(H2,17,20) VJBVYGXBOSHOIA-UHFFFAOYSA-N 41802 2-(2-benzylsulfonylbenzimidazol-1-yl)acetamide::2-[2-(benzylsulfonyl)-1H-benzimidazol-1-yl]acetamide::2-[2-(phenylmethyl)sulfonyl-1-benzimidazolyl]acetamide::2-[2-(phenylmethyl)sulfonylbenzimidazol-1-yl]ethanamide::MLS000064097::SMR000075943::cid_713670 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41802&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 713670 252622523 ZINC00107798 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84435 CC(C)(C)NC(=O)CC(CC(O)=O)c1ccccc1 InChI=1S/C15H21NO3/c1-15(2,3)16-13(17)9-12(10-14(18)19)11-7-5-4-6-8-11/h4-8,12H,9-10H2,1-3H3,(H,16,17)(H,18,19) YXIBWSNBWFLHSC-UHFFFAOYSA-N 41803 5-(tert-butylamino)-5-keto-3-phenyl-valeric acid::5-(tert-butylamino)-5-oxidanylidene-3-phenyl-pentanoic acid::5-(tert-butylamino)-5-oxo-3-phenylpentanoic acid::MLS000120585::SMR000097437::cid_3580533 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41803&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3580533 252622524 ZINC03646794 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84436 COc1ccc(Nc2oc(nc2C#N)-c2ccccc2Cl)cc1 InChI=1S/C17H12ClN3O2/c1-22-12-8-6-11(7-9-12)20-17-15(10-19)21-16(23-17)13-4-2-3-5-14(13)18/h2-9,20H,1H3 RXBBQCAWCVEWFQ-UHFFFAOYSA-N 39564 2-(2-chlorophenyl)-5-(4-methoxyanilino)-1,3-oxazole-4-carbonitrile::2-(2-chlorophenyl)-5-(4-methoxyanilino)-4-oxazolecarbonitrile::2-(2-chlorophenyl)-5-(p-anisidino)oxazole-4-carbonitrile::2-(2-chlorophenyl)-5-[(4-methoxyphenyl)amino]-1,3-oxazole-4-carbonitrile::MLS000103052::SMR000018585::cid_946201 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39564&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 946201 252620455 ZINC00544706 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84437 CN(C)c1ccc(cc1)C(=O)Nc1nc2CCCCc2s1 InChI=1S/C16H19N3OS/c1-19(2)12-9-7-11(8-10-12)15(20)18-16-17-13-5-3-4-6-14(13)21-16/h7-10H,3-6H2,1-2H3,(H,17,18,20) ZVKWKVBRZGMCEC-UHFFFAOYSA-N 37501 4-(dimethylamino)-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)benzamide::MLS000100704::SMR000017424::cid_746147 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37501&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 746147 252618472 ZINC00189361 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84438 OCC(CO)(CO)N=Cc1cc(Br)ccc1O InChI=1S/C11H14BrNO4/c12-9-1-2-10(17)8(3-9)4-13-11(5-14,6-15)7-16/h1-4,14-17H,5-7H2 VYXIAZMAMSTAGX-UHFFFAOYSA-N 41804 (6E)-4-bromanyl-6-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methylidene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[(2-hydroxy-1,1-dimethylol-ethyl)amino]methylene]cyclohexa-2,4-dien-1-one::(6E)-4-bromo-6-[[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]methylidene]-1-cyclohexa-2,4-dienone::(6E)-4-bromo-6-[[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]methylidene]cyclohexa-2,4-dien-1-one::MLS000106424::SMR000103391::cid_5406010 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41804&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5406010 252622525 ZINC13126620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84439 OC(=O)COc1ccc(Br)cc1CN=O InChI=1S/C9H8BrNO4/c10-7-1-2-8(15-5-9(12)13)6(3-7)4-11-14/h1-3H,4-5H2,(H,12,13) KWXZZLFHSHNEHC-UHFFFAOYSA-N 41805 2-[4-bromanyl-2-(hydroxyiminomethyl)phenoxy]ethanoic acid::2-[4-bromo-2-(hydroximinomethyl)phenoxy]acetic acid::2-[4-bromo-2-(hydroxyiminomethyl)phenoxy]acetic acid::MLS000113958::SMR000109848::cid_887160 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41805&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91896517 252622526 ZINC20166683 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84440 O=C(COc1ccccc1)Nc1ccc(cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C18H20N2O5S/c21-18(14-25-16-4-2-1-3-5-16)19-15-6-8-17(9-7-15)26(22,23)20-10-12-24-13-11-20/h1-9H,10-14H2,(H,19,21) WBYAGEJSHNRQAE-UHFFFAOYSA-N 41806 MLS000108227::N-(4-morpholin-4-ylsulfonylphenyl)-2-phenoxy-ethanamide::N-(4-morpholin-4-ylsulfonylphenyl)-2-phenoxyacetamide::N-(4-morpholinosulfonylphenyl)-2-phenoxy-acetamide::N-[4-(4-morpholinylsulfonyl)phenyl]-2-phenoxyacetamide::SMR000104188::cid_1010129 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41806&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1010129 252622527 ZINC00670442 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84441 CC1CCCC(C1)NC1CCCCNC1=O InChI=1S/C13H24N2O/c1-10-5-4-6-11(9-10)15-12-7-2-3-8-14-13(12)16/h10-12,15H,2-9H2,1H3,(H,14,16) QXPOPAWVLRBGAF-UHFFFAOYSA-N 41807 3-[(3-methylcyclohexyl)amino]-2-azepanone::3-[(3-methylcyclohexyl)amino]azepan-2-one::MLS000106622::SMR000110999::cid_2846276 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41807&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2846276 252622528 ZINC04989210 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84442 CC1CN(CCC1=O)C1CC(C)(C)NC(C)(C)C1 InChI=1S/C15H28N2O/c1-11-10-17(7-6-13(11)18)12-8-14(2,3)16-15(4,5)9-12/h11-12,16H,6-10H2,1-5H3 SISQFEZLNOSCNG-UHFFFAOYSA-N 41808 3-methyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-4-piperidinone::3-methyl-1-(2,2,6,6-tetramethyl-4-piperidyl)-4-piperidone::3-methyl-1-(2,2,6,6-tetramethylpiperidin-4-yl)piperidin-4-one::MLS000110137::SMR000106069::cid_547348 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41808&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 547348 252622529 ZINC19798180 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84443 Cc1ccc(OCC(=O)Nc2ccc(cc2)N2CCOCC2)cc1 InChI=1S/C19H22N2O3/c1-15-2-8-18(9-3-15)24-14-19(22)20-16-4-6-17(7-5-16)21-10-12-23-13-11-21/h2-9H,10-14H2,1H3,(H,20,22) YXYYNLLGGPQOKU-UHFFFAOYSA-N 41809 2-(4-methylphenoxy)-N-(4-morpholin-4-ylphenyl)acetamide::2-(4-methylphenoxy)-N-(4-morpholin-4-ylphenyl)ethanamide::2-(4-methylphenoxy)-N-(4-morpholinophenyl)acetamide::2-(4-methylphenoxy)-N-[4-(4-morpholinyl)phenyl]acetamide::MLS000107479::SMR000111845::cid_682558 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41809&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 682558 252622530 ZINC00048261 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84444 OC(=O)C1CCCCC1C(=O)Nc1ccc2OCCOc2c1 InChI=1S/C16H19NO5/c18-15(11-3-1-2-4-12(11)16(19)20)17-10-5-6-13-14(9-10)22-8-7-21-13/h5-6,9,11-12H,1-4,7-8H2,(H,17,18)(H,19,20) LWYYYWNLCLHWQV-UHFFFAOYSA-N 41810 2-(2,3-dihydro-1,4-benzodioxin-6-ylcarbamoyl)cyclohexane-1-carboxylic acid::2-(2,3-dihydro-1,4-benzodioxin-6-ylcarbamoyl)cyclohexanecarboxylic acid::2-[(2,3-dihydro-1,4-benzodioxin-6-ylamino)-oxomethyl]-1-cyclohexanecarboxylic acid::MLS000107960::SMR000103924::cid_2862450 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41810&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2862450 252622531 ZINC00113642 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84445 CCC(C)c1ccc(NC(=O)C2CC2)cc1 InChI=1S/C14H19NO/c1-3-10(2)11-6-8-13(9-7-11)15-14(16)12-4-5-12/h6-10,12H,3-5H2,1-2H3,(H,15,16) FFJKVRCOUHEYOK-UHFFFAOYSA-N 41811 MLS000110184::N-(4-butan-2-ylphenyl)cyclopropanecarboxamide::N-(4-sec-butylphenyl)cyclopropanecarboxamide::SMR000106115::cid_2886949 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41811&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2886949 252622532 ZINC00442522 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84446 COc1ccc(cc1)N(C)C1=NS(=O)(=O)c2ccccc12 InChI=1S/C15H14N2O3S/c1-17(11-7-9-12(20-2)10-8-11)15-13-5-3-4-6-14(13)21(18,19)16-15/h3-10H,1-2H3 LLZMQRONMABMKW-UHFFFAOYSA-N 41812 (1,1-Dioxo-1H-1lambda*6*-benzo[d]isothiazol-3-yl)-(4-methoxy-phenyl)-methyl-amine::(1,1-diketo-1,2-benzothiazol-3-yl)-(4-methoxyphenyl)-methyl-amine::MLS000068583::N-(4-methoxyphenyl)-N-methyl-1,1-bis(oxidanylidene)-1,2-benzothiazol-3-amine::N-(4-methoxyphenyl)-N-methyl-1,1-dioxo-1,2-benzothiazol-3-amine::SMR000122953::cid_785727 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41812&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 785727 252622533 ZINC00282597 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84447 O=C(N1CCCCC1)c1ccc(cc1)-n1cnnn1 InChI=1S/C13H15N5O/c19-13(17-8-2-1-3-9-17)11-4-6-12(7-5-11)18-10-14-15-16-18/h4-7,10H,1-3,8-9H2 JNUBUUVSAUHVCX-UHFFFAOYSA-N 41813 1-piperidinyl-[4-(1-tetrazolyl)phenyl]methanone::MLS000121381::Piperidin-1-yl-(4-tetrazol-1-yl-phenyl)-methanone::SMR000118722::cid_817486::piperidin-1-yl-[4-(1,2,3,4-tetrazol-1-yl)phenyl]methanone::piperidin-1-yl-[4-(tetrazol-1-yl)phenyl]methanone::piperidino-[4-(tetrazol-1-yl)phenyl]methanone Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41813&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 817486 252622534 ZINC00331408 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84448 COc1cc(OC)cc(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C16H24N2O4/c1-20-14-10-13(11-15(12-14)21-2)16(19)17-4-3-5-18-6-8-22-9-7-18/h10-12H,3-9H2,1-2H3,(H,17,19) ZSVNZECOKWHYAB-UHFFFAOYSA-N 41814 3,5-Dimethoxy-N-(3-morpholin-4-yl-propyl)-benzamide::3,5-dimethoxy-N-(3-morpholin-4-ylpropyl)benzamide::3,5-dimethoxy-N-(3-morpholinopropyl)benzamide::3,5-dimethoxy-N-[3-(4-morpholinyl)propyl]benzamide::MLS000121576::SMR000118971::cid_2163734 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2163734 252622535 ZINC19760161 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84449 COc1cc(ccc1-n1cnnn1)S(=O)(=O)N1CCCCCC1 InChI=1S/C14H19N5O3S/c1-22-14-10-12(6-7-13(14)19-11-15-16-17-19)23(20,21)18-8-4-2-3-5-9-18/h6-7,10-11H,2-5,8-9H2,1H3 IANQVUKPSLMWSM-UHFFFAOYSA-N 41815 1-(3-Methoxy-4-tetrazol-1-yl-benzenesulfonyl)-azepane::1-[3-methoxy-4-(1,2,3,4-tetrazol-1-yl)phenyl]sulfonylazepane::1-[3-methoxy-4-(1-tetrazolyl)phenyl]sulfonylazepane::1-[3-methoxy-4-(tetrazol-1-yl)phenyl]sulfonylazepane::MLS000123482::SMR000124037::cid_858983 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41815&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 858983 252622536 ZINC00414808 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84450 Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(Cl)cc1 InChI=1S/C13H10ClN5O2/c1-18-12(20)9-11(16-13(18)21)19(2)17-10(15-9)7-3-5-8(14)6-4-7/h3-6H,1-2H3 UCEGDYDPOSBUTP-UHFFFAOYSA-N 40314 3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::3-(4-chlorophenyl)-1,6-dimethyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone::3-(4-chlorophenyl)-1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::MLS000523518::SMR000122591::US9073941, 603::cid_460749 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40314&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 460749 252621140 ZINC00267651 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84451 Cc1nn(C)c2nc(=O)n(C)c(=O)c2n1 InChI=1S/C8H9N5O2/c1-4-9-5-6(13(3)11-4)10-8(15)12(2)7(5)14/h1-3H3 CPXHNWKHOFNPDO-UHFFFAOYSA-N 34671 1,3,6-Trimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::1,3,6-trimethylpyrimido[5,4-e][1,2,4]triazine-5,7-quinone::MLS000528498::SMR000121073::US9073941, 611::cid_460747 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34671&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 460747 252617321 ZINC00490878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84452 Cc1[nH]n2c(nc(cc2=O)-c2ccc(cc2)[N+]([O-])=O)c1-c1ccccc1 InChI=1S/C19H14N4O3/c1-12-18(14-5-3-2-4-6-14)19-20-16(11-17(24)22(19)21-12)13-7-9-15(10-8-13)23(25)26/h2-11,21H,1H3 XISRVALMPPEBHA-UHFFFAOYSA-N 37827 2-methyl-5-(4-nitrophenyl)-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one::5-{4-nitrophenyl}-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidin-7(4H)-one::MLS000547439::SMR000113532::cid_1051569 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37827&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1051569 252618787 ZINC05439269 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84453 CCOC(=O)c1c(C)n(C)c2c1-c1cc(Br)ccc1C(=O)C2=O InChI=1S/C17H14BrNO4/c1-4-23-17(22)12-8(2)19(3)14-13(12)11-7-9(18)5-6-10(11)15(20)16(14)21/h5-7H,4H2,1-3H3 HKEXSVHEPUVAPQ-UHFFFAOYSA-N 40316 8-bromo-2,3-dimethyl-4,5-dioxo-1-benzo[e]indolecarboxylic acid ethyl ester::8-bromo-4,5-diketo-2,3-dimethyl-benz[e]indole-1-carboxylic acid ethyl ester::MLS000548053::SMR000114488::cid_1736381::ethyl 8-bromanyl-2,3-dimethyl-4,5-bis(oxidanylidene)benzo[e]indole-1-carboxylate::ethyl 8-bromo-2,3-dimethyl-4,5-dioxo-4,5-dihydro-3H-benzo[e]indole-1-carboxylate::ethyl 8-bromo-2,3-dimethyl-4,5-dioxobenzo[e]indole-1-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens 722.99999 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40316&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1736381 252621142 ZINC02075226 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84454 Cc1ccc(NC2=CC(=NS(=O)(=O)c3cccs3)c3ccccc3C2=O)c(C)c1 InChI=1S/C22H18N2O3S2/c1-14-9-10-18(15(2)12-14)23-20-13-19(16-6-3-4-7-17(16)22(20)25)24-29(26,27)21-8-5-11-28-21/h3-13,23H,1-2H3 LCGOLHKLWOZZSZ-UHFFFAOYSA-N 41816 (NE)-N-[3-(2,4-dimethylanilino)-4-keto-1-naphthylidene]thiophene-2-sulfonamide::(NE)-N-[3-(2,4-dimethylanilino)-4-oxo-1-naphthalenylidene]-2-thiophenesulfonamide::(NE)-N-[3-(2,4-dimethylanilino)-4-oxonaphthalen-1-ylidene]thiophene-2-sulfonamide::(NE)-N-[3-[(2,4-dimethylphenyl)amino]-4-oxidanylidene-naphthalen-1-ylidene]thiophene-2-sulfonamide::MLS000549894::N-(3-(2,4-dimethylanilino)-4-oxo-1(4H)-naphthalenylidene)-2-thiophenesulfonamide::SMR000113727::cid_9549688 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41816&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9549688 252622537 ZINC13111032 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84455 Oc1ccc2ccc3cccc[n+]3c2c1 InChI=1S/C13H9NO/c15-12-7-5-10-4-6-11-3-1-2-8-14(11)13(10)9-12/h1-9H/p+1 PGMYAFHGARCXKK-UHFFFAOYSA-O 41817 9-benzo[c]quinolizin-11-iumol;iodide::9-hydroxypyrido[1,2-a]quinolinium::MLS000548877::SMR000113700::benzo[c]quinolizin-11-ium-9-ol;iodide::cid_9549757 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41817&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 849585 252622538 ZINC00384120 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84456 Clc1cc(c(Cl)s1)-c1ccnc(SCC=C)n1 InChI=1S/C11H8Cl2N2S2/c1-2-5-16-11-14-4-3-8(15-11)7-6-9(12)17-10(7)13/h2-4,6H,1,5H2 QEMZGRCLCNTCII-UHFFFAOYSA-N 41818 2-(allylsulfanyl)-4-(2,5-dichloro-3-thienyl)pyrimidine::2-(allylthio)-4-(2,5-dichloro-3-thienyl)pyrimidine::4-(2,5-dichloro-3-thiophenyl)-2-(prop-2-enylthio)pyrimidine::4-(2,5-dichlorothiophen-3-yl)-2-prop-2-enylsulfanylpyrimidine::4-[2,5-bis(chloranyl)thiophen-3-yl]-2-prop-2-enylsulfanyl-pyrimidine::MLS000540566::SMR000125824::cid_3806023 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41818&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3806023 252622539 ZINC05382813 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84457 Nc1ccc-2c(c1)C(=O)C(=O)c1ccccc-21 InChI=1S/C14H9NO2/c15-8-5-6-10-9-3-1-2-4-11(9)13(16)14(17)12(10)7-8/h1-7H,15H2 HENHQTJCDFNZOI-UHFFFAOYSA-N 50099737 2-Amino-phenanthrene-9,10-dione::CHEMBL417727::US9073941, 902::cid_254021 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099737&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 254021 103996562 CHEMBL417727 ZINC01713558 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84458 CC(C)Sc1nc(N2CCOCC2)c2CN(C)C(C)(C)Cc2c1C#N InChI=1S/C19H28N4OS/c1-13(2)25-18-15(11-20)14-10-19(3,4)22(5)12-16(14)17(21-18)23-6-8-24-9-7-23/h13H,6-10,12H2,1-5H3 VOFFAYCPMVCFGB-UHFFFAOYSA-N 41819 3-(isopropylthio)-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-yl-5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-(4-morpholinyl)-3-(propan-2-ylthio)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::6,6,7-trimethyl-1-morpholin-4-yl-3-propan-2-ylsulfanyl-5,8-dihydro-2,7-naphthyridine-4-carbonitrile::MLS000552515::SMR000146030::cid_3790338 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41819&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3790338 252622540 ZINC13142403 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84459 Cc1cccc(C)c1NC1=NC(=S)N(c2ccccc2)C11CCOC(C)(C)C1 InChI=1S/C23H27N3OS/c1-16-9-8-10-17(2)19(16)24-20-23(13-14-27-22(3,4)15-23)26(21(28)25-20)18-11-6-5-7-12-18/h5-12H,13-15H2,1-4H3,(H,24,25,28) XOQWQVNJXRZWGS-UHFFFAOYSA-N 41820 4-(2,6-dimethylanilino)-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione::4-[(2,6-dimethylphenyl)amino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diazaspiro[4.5]dec-3-ene-2-thione::4-[(Z)-2,6-Dimethyl-phenylimino]-7,7-dimethyl-1-phenyl-8-oxa-1,3-diaza-spiro[4.5]decane-2-thione::MLS000552149::SMR000145863::cid_4005418 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41820&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4005418 252622541 ZINC17138319 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84460 O=C(CC1N(CCNC1=O)C(=S)Nc1ccccc1)Nc1ccc2OCCOc2c1 InChI=1S/C21H22N4O4S/c26-19(23-15-6-7-17-18(12-15)29-11-10-28-17)13-16-20(27)22-8-9-25(16)21(30)24-14-4-2-1-3-5-14/h1-7,12,16H,8-11,13H2,(H,22,27)(H,23,26)(H,24,30) BXQVEPADPAZKIN-UHFFFAOYSA-N 41821 2-[1-(anilinocarbonothioyl)-3-oxo-2-piperazinyl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::2-[1-[anilino(sulfanylidene)methyl]-3-oxo-2-piperazinyl]-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide::MLS000538345::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-keto-1-(phenylthiocarbamoyl)piperazin-2-yl]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-oxidanylidene-1-(phenylcarbamothioyl)piperazin-2-yl]ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[3-oxo-1-(phenylcarbamothioyl)piperazin-2-yl]acetamide::SMR000144382::cid_2968933 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41821&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2968933 252622542 ZINC01079150 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84461 CS(=O)(=O)N1CCN(C\C=C\c2ccccc2)CC1 InChI=1S/C14H20N2O2S/c1-19(17,18)16-12-10-15(11-13-16)9-5-8-14-6-3-2-4-7-14/h2-8H,9-13H2,1H3/b8-5+ FOVOVNHELYBDGP-VMPITWQZSA-N 41822 1-(methylsulfonyl)-4-(3-phenyl-2-propen-1-yl)piperazine::1-[(E)-cinnamyl]-4-mesyl-piperazine::1-methylsulfonyl-4-[(E)-3-phenylprop-2-enyl]piperazine::MLS000530258::SMR000135235::cid_750930 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41822&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 750930 252622543 ZINC19536338 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84462 CCC(=O)Nc1ccccc1C(=O)NC1CCCCC1 InChI=1S/C16H22N2O2/c1-2-15(19)18-14-11-7-6-10-13(14)16(20)17-12-8-4-3-5-9-12/h6-7,10-12H,2-5,8-9H2,1H3,(H,17,20)(H,18,19) PWIYNYQZCMUDNH-UHFFFAOYSA-N 41823 MLS000538265::N-cyclohexyl-2-(1-oxopropylamino)benzamide::N-cyclohexyl-2-(propanoylamino)benzamide::N-cyclohexyl-2-(propionylamino)benzamide::N-cyclohexyl-2-propionamido-benzamide::SMR000144305::cid_974692 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41823&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 974692 252622544 ZINC00615774 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84463 Cc1ccc(CNC(=O)c2cc3c(n2C)c2ccccc2n(C)c3=O)cc1 InChI=1S/C22H21N3O2/c1-14-8-10-15(11-9-14)13-23-21(26)19-12-17-20(24(19)2)16-6-4-5-7-18(16)25(3)22(17)27/h4-12H,13H2,1-3H3,(H,23,26) GOCAPSRBFPHRLB-UHFFFAOYSA-N 41824 1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxidanylidene-pyrrolo[3,2-c]quinoline-2-carboxamide::1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxo-2-pyrrolo[3,2-c]quinolinecarboxamide::1,5-dimethyl-N-[(4-methylphenyl)methyl]-4-oxopyrrolo[3,2-c]quinoline-2-carboxamide::4-keto-1,5-dimethyl-N-(4-methylbenzyl)pyrrolo[3,2-c]quinoline-2-carboxamide::MLS000522546::SMR000127813::cid_6622575 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41824&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6622575 252622545 ZINC04938861 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84464 COc1ccc2C(CC(O)=O)OC(=O)c2c1OC InChI=1S/C12H12O6/c1-16-7-4-3-6-8(5-9(13)14)18-12(15)10(6)11(7)17-2/h3-4,8H,5H2,1-2H3,(H,13,14) KAZZPXMHIZJNFS-UHFFFAOYSA-N 41825 (4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl)acetic acid::2-(3-keto-4,5-dimethoxy-phthalan-1-yl)acetic acid::2-(4,5-dimethoxy-3-oxidanylidene-1H-2-benzofuran-1-yl)ethanoic acid::2-(4,5-dimethoxy-3-oxo-1H-2-benzofuran-1-yl)acetic acid::2-(4,5-dimethoxy-3-oxo-1H-isobenzofuran-1-yl)acetic acid::MLS000530421::SMR000135399::cid_2863889 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41825&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2863889 252622546 ZINC00434141 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84465 COC(=O)c1ccccc1NC1=CC(=NS(=O)(=O)c2cccs2)c2ccccc2C1=O InChI=1S/C22H16N2O5S2/c1-29-22(26)16-9-4-5-10-17(16)23-19-13-18(14-7-2-3-8-15(14)21(19)25)24-31(27,28)20-11-6-12-30-20/h2-13,23H,1H3 SQTXZQUPJDPRBX-UHFFFAOYSA-N 41826 2-[[(4E)-1-keto-4-(2-thienylsulfonylimino)-2-naphthyl]amino]benzoic acid methyl ester::2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonylimino-2-naphthalenyl]amino]benzoic acid methyl ester::MLS000521465::SMR000131873::cid_9550941::methyl 2-[[(4E)-1-oxidanylidene-4-thiophen-2-ylsulfonylimino-naphthalen-2-yl]amino]benzoate::methyl 2-[[(4E)-1-oxo-4-thiophen-2-ylsulfonyliminonaphthalen-2-yl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9550941 252622547 ZINC57608287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84466 O=C(Nc1nc2ccccc2s1)c1cc2COc3ccccc3-c2s1 InChI=1S/C19H12N2O2S2/c22-18(21-19-20-13-6-2-4-8-15(13)25-19)16-9-11-10-23-14-7-3-1-5-12(14)17(11)24-16/h1-9H,10H2,(H,20,21,22) YMEYVTRNCWQUKW-UHFFFAOYSA-N 40208 MLS000522634::N-(1,3-benzothiazol-2-yl)-4H-thieno[3,2-c][1]benzopyran-2-carboxamide::N-(1,3-benzothiazol-2-yl)-4H-thieno[3,2-c]chromene-2-carboxamide::SMR000127901::cid_9550946 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40208&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9550946 252621036 ZINC05050072 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84467 Cc1nc2cccc(C)n2c(=O)c1Cl InChI=1S/C10H9ClN2O/c1-6-4-3-5-8-12-7(2)9(11)10(14)13(6)8/h3-5H,1-2H3 CAMDPFYIYQWBHS-UHFFFAOYSA-N 41827 3-chloranyl-2,6-dimethyl-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethyl-4-pyrido[1,2-a]pyrimidinone::3-chloro-2,6-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethyl-pyrido[1,2-a]pyrimidin-4-one::3-chloro-2,6-dimethylpyrido[1,2-a]pyrimidin-4-one::MLS000539503::SMR000125161::cid_3255478 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41827&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3255478 252622548 ZINC03029426 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84468 Cn1cc(SCC(=O)Nc2ccc3OCCOc3c2)c2ccccc12 InChI=1S/C19H18N2O3S/c1-21-11-18(14-4-2-3-5-15(14)21)25-12-19(22)20-13-6-7-16-17(10-13)24-9-8-23-16/h2-7,10-11H,8-9,12H2,1H3,(H,20,22) KEWYZVKHGDWOBD-UHFFFAOYSA-N 41828 MLS000529783::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(1-methylindol-3-yl)sulfanyl-ethanamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(1-methylindol-3-yl)sulfanylacetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(1-methyl-3-indolyl)thio]acetamide::N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[(1-methylindol-3-yl)thio]acetamide::SMR000126809::cid_4663634 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41828&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4663634 252622549 ZINC03581738 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84469 Cn1c(nc2ccccc12)-c1cc2ccc(OC(=O)C(C)(C)C)cc2oc1=O InChI=1S/C22H20N2O4/c1-22(2,3)21(26)27-14-10-9-13-11-15(20(25)28-18(13)12-14)19-23-16-7-5-6-8-17(16)24(19)4/h5-12H,1-4H3 SLVVLPLLOLFSNR-UHFFFAOYSA-N 41829 2,2-Dimethyl-propionic acid 3-(1-methyl-1H-benzoimidazol-2-yl)-2-oxo-2H-chromen-7-yl ester::2,2-dimethylpropanoic acid [3-(1-methyl-2-benzimidazolyl)-2-oxo-1-benzopyran-7-yl] ester::2,2-dimethylpropionic acid [2-keto-3-(1-methylbenzimidazol-2-yl)chromen-7-yl] ester::MLS000556974::SMR000148091::[3-(1-methylbenzimidazol-2-yl)-2-oxidanylidene-chromen-7-yl] 2,2-dimethylpropanoate::[3-(1-methylbenzimidazol-2-yl)-2-oxochromen-7-yl] 2,2-dimethylpropanoate::cid_1522831 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41829&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1522831 252622550 ZINC01447934 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84470 CCCc1nc2sc3CCCCc3c2c(=O)n1NC(=O)CCC(O)=O InChI=1S/C17H21N3O4S/c1-2-5-12-18-16-15(10-6-3-4-7-11(10)25-16)17(24)20(12)19-13(21)8-9-14(22)23/h2-9H2,1H3,(H,19,21)(H,22,23) UFZNWSZCQFKQIW-UHFFFAOYSA-N 41830 4-keto-4-[(4-keto-2-propyl-5,6,7,8-tetrahydrobenzothiopheno[2,3-d]pyrimidin-3-yl)amino]butyric acid::4-oxidanylidene-4-[(4-oxidanylidene-2-propyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-3-yl)amino]butanoic acid::4-oxo-4-[(4-oxo-2-propyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-3-yl)amino]butanoic acid::MLS000550849::N-(4-Oxo-2-propyl-5,6,7,8-tetrahydro-4H-benzo[4,5]thieno[2,3-d]pyrimidin-3-yl)-succinamic acid::SMR000144977::cid_1861941 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41830&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1861941 252622551 ZINC02230233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84471 Cc1oc-2c(c1C(=O)c1ccccc1)C(=O)C(=O)c1ccccc-21 InChI=1S/C20H12O4/c1-11-15(17(21)12-7-3-2-4-8-12)16-19(23)18(22)13-9-5-6-10-14(13)20(16)24-11/h2-10H,1H3 XEMFSKXFWNHKIS-UHFFFAOYSA-N 34691 2-methyl-3-(phenylcarbonyl)benzo[g][1]benzofuran-4,5-dione::3-Benzoyl-2-methyl-naphtho[1,2-b]furan-4,5-dione::3-benzoyl-2-methyl-benzo[g]benzofuran-4,5-quinone::3-benzoyl-2-methylbenzo[g][1]benzofuran-4,5-dione::3-benzoyl-2-methylbenzo[g]benzofuran-4,5-dione::MLS000554105::SMR000146422::cid_3816369 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34691&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3816369 252617341 ZINC04785917 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84472 CC(=O)N(N=C1Sc2ccccc2C1=O)c1cccc(C)c1 InChI=1S/C17H14N2O2S/c1-11-6-5-7-13(10-11)19(12(2)20)18-17-16(21)14-8-3-4-9-15(14)22-17/h3-10H,1-2H3 ZTBUBWXLRCXSOT-UHFFFAOYSA-N 41831 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-m-tolyl-hydrazide::MLS000552764::N-(3-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide::N-(3-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(m-tolyl)acetamide::SMR000146279::cid_759945 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41831&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401878 252622552 ZINC12559942 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84473 CC(=O)N(N=C1Sc2ccccc2C1=O)c1ccccc1C InChI=1S/C17H14N2O2S/c1-11-7-3-5-9-14(11)19(12(2)20)18-17-16(21)13-8-4-6-10-15(13)22-17/h3-10H,1-2H3 OBPOWEVMSNKZCM-UHFFFAOYSA-N 41832 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-o-tolyl-hydrazide::MLS000552762::N-(2-methylphenyl)-N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]ethanamide::N-(2-methylphenyl)-N-[(3-oxo-1-benzothiophen-2-ylidene)amino]acetamide::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-(o-tolyl)acetamide::SMR000146277::cid_759936 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41832&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401874 252622553 ZINC12561994 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84474 CC(=O)N(N=C1Sc2ccccc2C1=O)c1ccccc1 InChI=1S/C16H12N2O2S/c1-11(19)18(12-7-3-2-4-8-12)17-16-15(20)13-9-5-6-10-14(13)21-16/h2-10H,1H3 KYSFXQOZNRWVLN-UHFFFAOYSA-N 41833 Acetic acid N'-[3-oxo-3H-benzo[b]thiophen-(2Z)-ylidene]-N-phenyl-hydrazide::MLS000552761::N-[(3-ketobenzothiophen-2-ylidene)amino]-N-phenyl-acetamide::N-[(3-oxidanylidene-1-benzothiophen-2-ylidene)amino]-N-phenyl-ethanamide::N-[(3-oxo-1-benzothiophen-2-ylidene)amino]-N-phenylacetamide::N-[(Z)-(3-ketobenzothiophen-2-ylidene)amino]-N-phenyl-acetamide::SMR000146276::cid_759934 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41833&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401873 252622554 ZINC12561922 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84475 CCOc1ccccc1N1CCN(CC1)C1=C(NS(=O)(=O)c2cccs2)C(=O)c2ccccc2C1=O InChI=1S/C26H25N3O5S2/c1-2-34-21-11-6-5-10-20(21)28-13-15-29(16-14-28)24-23(27-36(32,33)22-12-7-17-35-22)25(30)18-8-3-4-9-19(18)26(24)31/h3-12,17,27H,2,13-16H2,1H3 IWDXUFGXDULHDB-UHFFFAOYSA-N 41834 MLS000551587::N-[1,4-diketo-3-(4-o-phenetylpiperazino)-2-naphthyl]thiophene-2-sulfonamide::N-[3-[4-(2-ethoxyphenyl)-1-piperazinyl]-1,4-dioxo-2-naphthalenyl]-2-thiophenesulfonamide::N-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,4-bis(oxidanylidene)naphthalen-2-yl]thiophene-2-sulfonamide::N-[3-[4-(2-ethoxyphenyl)piperazin-1-yl]-1,4-dioxonaphthalen-2-yl]thiophene-2-sulfonamide::SMR000145512::Thiophene-2-sulfonic acid {3-[4-(2-ethoxy-phenyl)-piperazin-1-yl]-1,4-dioxo-1,4-dihydro-naphthalen-2-yl}-amide::cid_1423408 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41834&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1423408 252622555 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84476 CC(C)Nc1nnc(SCC(=O)c2c(N)n(Cc3ccccc3)c(=O)n(C)c2=O)s1 InChI=1S/C19H22N6O3S2/c1-11(2)21-17-22-23-18(30-17)29-10-13(26)14-15(20)25(19(28)24(3)16(14)27)9-12-7-5-4-6-8-12/h4-8,11H,9-10,20H2,1-3H3,(H,21,22) OGOGCOROTDLCTB-UHFFFAOYSA-N 41835 6-amino-1-benzyl-3-methyl-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione::6-amino-1-benzyl-5-[2-[[5-(isopropylamino)-1,3,4-thiadiazol-2-yl]thio]acetyl]-3-methyl-pyrimidine-2,4-quinone::6-amino-3-methyl-5-[1-oxo-2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]thio]ethyl]-1-(phenylmethyl)pyrimidine-2,4-dione::6-azanyl-3-methyl-1-(phenylmethyl)-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanoyl]pyrimidine-2,4-dione::MLS000568091::SMR000154422::cid_2501656 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41835&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2501656 252622556 ZINC03383369 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84477 O=C1C(=O)c2ccccc2-c2ccccc12 InChI=1S/C14H8O2/c15-13-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14(13)16/h1-8H YYVYAPXYZVYDHN-UHFFFAOYSA-N 22857 1,2-Dione-Based Compound, 14::9,10-dihydrophenanthrene-9,10-dione::CHEMBL51931::Phenanthrene-9,10 dione::cid_6763 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22857&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6763 49846671 37454 CHEMBL51931 C03243 ZINC01529614 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84478 Cc1nn(CCc2n[nH]c(=S)n2-c2cccc(C)c2)c(C)c1[N+]([O-])=O InChI=1S/C16H18N6O2S/c1-10-5-4-6-13(9-10)21-14(17-18-16(21)25)7-8-20-12(3)15(22(23)24)11(2)19-20/h4-6,9H,7-8H2,1-3H3,(H,18,25) VRRDUIBPADYHAW-UHFFFAOYSA-N 41836 3-(2-{4-nitro-3,5-dimethyl-1H-pyrazol-1-yl}ethyl)-4-(3-methylphenyl)-5-sulfanyl-4H-1,2,4-triazole::3-[2-(3,5-dimethyl-4-nitro-1-pyrazolyl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)ethyl]-4-(m-tolyl)-1H-1,2,4-triazole-5-thione::3-[2-(3,5-dimethyl-4-nitropyrazol-1-yl)ethyl]-4-(3-methylphenyl)-1H-1,2,4-triazole-5-thione::MLS000538660::SMR000160121::cid_998946 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41836&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 998946 252622557 ZINC05427265 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84479 Cc1cccc2[nH]c3c(ncnc3c12)N1CCN(CC1)C(=O)c1ccco1 InChI=1S/C20H19N5O2/c1-13-4-2-5-14-16(13)17-18(23-14)19(22-12-21-17)24-7-9-25(10-8-24)20(26)15-6-3-11-27-15/h2-6,11-12,23H,7-10H2,1H3 IRQKMWLRGOXGDP-UHFFFAOYSA-N 41837 2-furanyl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)-1-piperazinyl]methanone::2-furyl-[4-(9-methyl-5H-pyrimid[5,4-b]indol-4-yl)piperazino]methanone::Furan-2-yl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)-piperazin-1-yl]-methanone::MLS000558194::SMR000148910::cid_1979644::furan-2-yl-[4-(9-methyl-5H-pyrimido[5,4-b]indol-4-yl)piperazin-1-yl]methanone Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1979644 252622558 ZINC02368389 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84480 Nc1cc(nn1S(=O)(=O)c1cccc2nsnc12)-c1ccc(Br)cc1 InChI=1S/C15H10BrN5O2S2/c16-10-6-4-9(5-7-10)12-8-14(17)21(18-12)25(22,23)13-3-1-2-11-15(13)20-24-19-11/h1-8H,17H2 WSZWPRMGVHHVON-UHFFFAOYSA-N 41838 2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)-3-pyrazolamine::2-(2,1,3-benzothiadiazol-4-ylsulfonyl)-5-(4-bromophenyl)pyrazol-3-amine::MLS000523036::SMR000128302::[5-(4-bromophenyl)-2-piazthiol-4-ylsulfonyl-pyrazol-3-yl]amine::cid_11957251 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11957251 252622559 ZINC08680561 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84481 NC(=O)C1CCN(CC1)C1=C(Cl)C(=O)c2ccccc2C1=O InChI=1S/C16H15ClN2O3/c17-12-13(19-7-5-9(6-8-19)16(18)22)15(21)11-4-2-1-3-10(11)14(12)20/h1-4,9H,5-8H2,(H2,18,22) JBMKSILOCSVHGX-UHFFFAOYSA-N 41839 1-(3-chloro-1,4-diketo-2-naphthyl)isonipecotamide::1-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-4-piperidinecarboxamide::1-(3-chloro-1,4-dioxo-2-naphthalenyl)-4-piperidinecarboxamide::1-(3-chloro-1,4-dioxonaphthalen-2-yl)piperidine-4-carboxamide::1-[3-chloranyl-1,4-bis(oxidanylidene)naphthalen-2-yl]piperidine-4-carboxamide::MLS000547001::SMR000180199::cid_1481943 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41839&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1481943 252622560 ZINC01395148 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84482 Clc1cccc(Cl)c1Cn1cccc(NC(=O)c2c(Cl)cccc2Cl)c1=O InChI=1S/C19H12Cl4N2O2/c20-12-4-1-5-13(21)11(12)10-25-9-3-8-16(19(25)27)24-18(26)17-14(22)6-2-7-15(17)23/h1-9H,10H2,(H,24,26) YODRLVBIQYILMX-UHFFFAOYSA-N 41840 2,6-dichloro-N-[1-(2,6-dichlorobenzyl)-2-keto-3-pyridyl]benzamide::2,6-dichloro-N-[1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydro-3-pyridinyl]benzenecarboxamide::2,6-dichloro-N-[1-[(2,6-dichlorophenyl)methyl]-2-oxo-3-pyridinyl]benzamide::2,6-dichloro-N-[1-[(2,6-dichlorophenyl)methyl]-2-oxopyridin-3-yl]benzamide::MLS000543295::N-[1-[[2,6-bis(chloranyl)phenyl]methyl]-2-oxidanylidene-pyridin-3-yl]-2,6-bis(chloranyl)benzamide::SMR000169264::cid_3679261 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41840&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3679261 252622561 ZINC03041620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84483 Nc1cc2nsnc2cc1Br InChI=1S/C6H4BrN3S/c7-3-1-5-6(2-4(3)8)10-11-9-5/h1-2H,8H2 CDEJXRZSAIZTRF-UHFFFAOYSA-N 40726 (6-bromopiazthiol-5-yl)amine::5-bromanyl-2,1,3-benzothiadiazol-6-amine::5-bromo-2,1,3-benzothiadiazol-6-amine::6-Bromo-benzo[1,2,5]thiadiazol-5-ylamine::MLS000556153::SMR000174162::cid_3096032 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40726&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3096032 252621543 ZINC02566853 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84484 Cc1ccc(cc1)C(=O)c1c[nH]c(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C20H25N3O3/c1-15-3-5-16(6-4-15)19(24)17-13-18(22-14-17)20(25)21-7-2-8-23-9-11-26-12-10-23/h3-6,13-14,22H,2,7-12H2,1H3,(H,21,25) XQVAGUMIWDNJTA-UHFFFAOYSA-N 41841 4-(4-methylbenzoyl)-N-(3-morpholin-4-ylpropyl)-1H-pyrrole-2-carboxamide::4-(4-methylbenzoyl)-N-(3-morpholinopropyl)-1H-pyrrole-2-carboxamide::4-(4-methylphenyl)carbonyl-N-(3-morpholin-4-ylpropyl)-1H-pyrrole-2-carboxamide::4-[(4-methylphenyl)-oxomethyl]-N-[3-(4-morpholinyl)propyl]-1H-pyrrole-2-carboxamide::MLS000546923::N-(3-morpholinopropyl)-4-p-toluoyl-1H-pyrrole-2-carboxamide::SMR000180121::cid_3813794 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41841&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3813794 252622562 ZINC20405048 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84485 Cc1ccccc1Oc1ncnc2oc(cc12)-c1ccccc1 InChI=1S/C19H14N2O2/c1-13-7-5-6-10-16(13)22-18-15-11-17(14-8-3-2-4-9-14)23-19(15)21-12-20-18/h2-12H,1H3 ATKPLDDGMIKJMB-UHFFFAOYSA-N 41842 4-(2-methylphenoxy)-6-phenyl-furo[2,3-d]pyrimidine::4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidine::MLS000327159::SMR000179731::cid_3825639 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41842&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3825639 252622563 ZINC06218639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84486 OC1(N2CCCCC2)C(=O)Nc2ccc(cc12)[N+]([O-])=O InChI=1S/C13H15N3O4/c17-12-13(18,15-6-2-1-3-7-15)10-8-9(16(19)20)4-5-11(10)14-12/h4-5,8,18H,1-3,6-7H2,(H,14,17) YNAYNLVTESDOLF-UHFFFAOYSA-N 41843 3-hydroxy-5-nitro-3-(1-piperidinyl)-1,3-dihydro-2H-indol-2-one::3-hydroxy-5-nitro-3-(1-piperidinyl)-1H-indol-2-one::3-hydroxy-5-nitro-3-piperidin-1-yl-1H-indol-2-one::3-hydroxy-5-nitro-3-piperidino-oxindole::5-nitro-3-oxidanyl-3-piperidin-1-yl-1H-indol-2-one::MLS000579145::SMR000186733::cid_2859373 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41843&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2859373 252622564 ZINC04155872 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84487 CCN1C(=O)\C(=C\c2nc3ccccc3c(=O)n2-c2ccccc2)c2ccccc12 InChI=1S/C25H19N3O2/c1-2-27-22-15-9-7-12-18(22)20(24(27)29)16-23-26-21-14-8-6-13-19(21)25(30)28(23)17-10-4-3-5-11-17/h3-16H,2H2,1H3/b20-16+ YTNXBDRGDUEWNI-CAPFRKAQSA-N 41844 2-[(1-ethyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-3-phenyl-4(3H)-quinazolinone::2-[(E)-(1-ethyl-2-keto-indolin-3-ylidene)methyl]-3-phenyl-quinazolin-4-one::2-[(E)-(1-ethyl-2-oxidanylidene-indol-3-ylidene)methyl]-3-phenyl-quinazolin-4-one::2-[(E)-(1-ethyl-2-oxo-3-indolylidene)methyl]-3-phenyl-4-quinazolinone::2-[(E)-(1-ethyl-2-oxoindol-3-ylidene)methyl]-3-phenylquinazolin-4-one::MLS000570466::SMR000186892::cid_5336431 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41844&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5336431 252622565 ZINC32609533 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84488 [O-][N+](=O)c1cccc(c1)C(=O)NC(NC(=S)Nc1ccc(Cl)cc1Cl)C(Cl)(Cl)Cl InChI=1S/C16H11Cl5N4O3S/c17-9-4-5-12(11(18)7-9)22-15(29)24-14(16(19,20)21)23-13(26)8-2-1-3-10(6-8)25(27)28/h1-7,14H,(H,23,26)(H2,22,24,29) VAKBSJSQKQOLBN-UHFFFAOYSA-N 41845 3-nitro-N-[2,2,2-trichloro-1-({[(2,4-dichlorophenyl)amino]carbonothioyl}amino)ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[(2,4-dichlorophenyl)carbamothioylamino]ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[(2,4-dichlorophenyl)thiocarbamoylamino]ethyl]benzamide::3-nitro-N-[2,2,2-trichloro-1-[[(2,4-dichloroanilino)-sulfanylidenemethyl]amino]ethyl]benzamide::3-nitro-N-[2,2,2-tris(chloranyl)-1-[(2,4-dichlorophenyl)carbamothioylamino]ethyl]benzamide::MLS000573675::SMR000184524::cid_2830011 Serine/threonine-protein kinase PLK1 Homo sapiens 28163.00011 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41845&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2830011 252622566 ZINC17320775 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84489 [O-][N+](=O)c1ccc(cc1NCC1CCCO1)N1CCNCC1 InChI=1S/C15H22N4O3/c20-19(21)15-4-3-12(18-7-5-16-6-8-18)10-14(15)17-11-13-2-1-9-22-13/h3-4,10,13,16-17H,1-2,5-9,11H2 NBQUAKXLTFLOAI-UHFFFAOYSA-N 41846 (2-nitro-5-piperazino-phenyl)-(tetrahydrofurfuryl)amine::2-nitro-5-(1-piperazinyl)-N-(tetrahydro-2-furanylmethyl)aniline::2-nitro-N-(2-oxolanylmethyl)-5-(1-piperazinyl)aniline::2-nitro-N-(oxolan-2-ylmethyl)-5-piperazin-1-yl-aniline::2-nitro-N-(oxolan-2-ylmethyl)-5-piperazin-1-ylaniline::MLS000576313::SMR000197953::cid_2933906 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41846&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2933906 252622567 ZINC04140715 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 84490 [O-][N+](=O)c1ccc(\C=C(\NC(=O)c2ccccc2)C(=O)NCCc2ccccc2)cc1 InChI=1S/C24H21N3O4/c28-23(20-9-5-2-6-10-20)26-22(17-19-11-13-21(14-12-19)27(30)31)24(29)25-16-15-18-7-3-1-4-8-18/h1-14,17H,15-16H2,(H,25,29)(H,26,28)/b22-17+ MIWCELHLXXHHJL-OQKWZONESA-N 41847 MLS000575866::N-(2-(4-nitrophenyl)-1-{[(2-phenylethyl)amino]carbonyl}vinyl)benzamide::N-[(E)-1-(4-nitrophenyl)-3-oxidanylidene-3-(2-phenylethylamino)prop-1-en-2-yl]benzamide::N-[(E)-1-(4-nitrophenyl)-3-oxo-3-(2-phenylethylamino)prop-1-en-2-yl]benzamide::N-[(E)-2-(4-nitrophenyl)-1-(phenethylcarbamoyl)vinyl]benzamide::SMR000196901::cid_5735412 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q2N58JS6 aid936 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41847&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5735412 252622568 ZINC04844883 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85004 CCOC(=O)c1ccccc1NC(=O)c1c(O)[nH]c(=O)[nH]c1=O InChI=1S/C14H13N3O6/c1-2-23-13(21)7-5-3-4-6-8(7)15-10(18)9-11(19)16-14(22)17-12(9)20/h3-6H,2H2,1H3,(H,15,18)(H3,16,17,19,20,22) OCMCPFPFSHSNFL-UHFFFAOYSA-N 46096 2-[(6-hydroxy-2,4-diketo-1H-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::2-[[(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00294846::cid_15947078::ethyl 2-[(6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carbonyl)amino]benzoate::ethyl 2-[[6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 15947078 252626666 ZINC15973628 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85005 CCOC(=O)c1ccccc1NC(=O)c1c(O)[nH]c(=S)[nH]c1=O InChI=1S/C14H13N3O5S/c1-2-22-13(21)7-5-3-4-6-8(7)15-10(18)9-11(19)16-14(23)17-12(9)20/h3-6H,2H2,1H3,(H,15,18)(H3,16,17,19,20,23) BIWCSCOJAVGBPH-UHFFFAOYSA-N 46097 2-[(6-hydroxy-4-keto-2-thioxo-1H-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::2-[[(6-hydroxy-4-oxo-2-sulfanylidene-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00294847::cid_16654008::ethyl 2-[(6-hydroxy-4-oxo-2-sulfanylidene-1H-pyrimidine-5-carbonyl)amino]benzoate::ethyl 2-[(6-oxidanyl-4-oxidanylidene-2-sulfanylidene-1H-pyrimidin-5-yl)carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46097&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654008 252626667 ZINC15952740 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85006 CCOC(=O)c1ccc(NS(=O)(=O)c2c(N)n(C)c(=O)n(C)c2=O)cc1 InChI=1S/C15H18N4O6S/c1-4-25-14(21)9-5-7-10(8-6-9)17-26(23,24)11-12(16)18(2)15(22)19(3)13(11)20/h5-8,17H,4,16H2,1-3H3 YZZZNFOAGQGERC-UHFFFAOYSA-N 46098 4-[(4-amino-1,3-dimethyl-2,6-dioxo-5-pyrimidinyl)sulfonylamino]benzoic acid ethyl ester::4-[(4-amino-2,6-diketo-1,3-dimethyl-pyrimidin-5-yl)sulfonylamino]benzoic acid ethyl ester::UPDDI-00294848::cid_16654009::ethyl 4-[(4-amino-1,3-dimethyl-2,6-dioxopyrimidin-5-yl)sulfonylamino]benzoate::ethyl 4-[[4-azanyl-1,3-dimethyl-2,6-bis(oxidanylidene)pyrimidin-5-yl]sulfonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46098&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654009 252626668 ZINC15952739 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85007 CCOC(=O)c1cccc(NC(=O)c2c(O)[nH]c(=O)[nH]c2=O)c1 InChI=1S/C14H13N3O6/c1-2-23-13(21)7-4-3-5-8(6-7)15-10(18)9-11(19)16-14(22)17-12(9)20/h3-6H,2H2,1H3,(H,15,18)(H3,16,17,19,20,22) BZNDEFJMUGRRQS-UHFFFAOYSA-N 46099 3-[(6-hydroxy-2,4-diketo-1H-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::3-[[(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00294850::cid_16654011::ethyl 3-[(6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carbonyl)amino]benzoate::ethyl 3-[[6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46099&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654011 252626669 ZINC15952738 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85008 Oc1[nH]c(=O)[nH]c(=O)c1C(=O)Nc1ccccc1 InChI=1S/C11H9N3O4/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18) VKWYRWQIBQMDFJ-UHFFFAOYSA-N 46100 6-hydroxy-2,4-diketo-N-phenyl-1H-pyrimidine-5-carboxamide::6-hydroxy-2,4-dioxo-N-phenyl-1H-pyrimidine-5-carboxamide::6-oxidanyl-2,4-bis(oxidanylidene)-N-phenyl-1H-pyrimidine-5-carboxamide::UPDDI-00294852::US9428466, 2-oxo-desthiomerbarone::cid_100782 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46100&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 100782 252626670 ZINC01586033 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85009 CCOc1ccc(NC(=O)c2c(O)[nH]c(=O)[nH]c2=O)cc1 InChI=1S/C13H13N3O5/c1-2-21-8-5-3-7(4-6-8)14-10(17)9-11(18)15-13(20)16-12(9)19/h3-6H,2H2,1H3,(H,14,17)(H3,15,16,18,19,20) PGKZWQVKTKYOKA-UHFFFAOYSA-N 46101 6-hydroxy-2,4-diketo-N-p-phenetyl-1H-pyrimidine-5-carboxamide::N-(4-ethoxyphenyl)-6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carboxamide::N-(4-ethoxyphenyl)-6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidine-5-carboxamide::UPDDI-00294853::cid_16654013 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46101&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654013 252626671 ZINC15952737 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85010 CCCCOC(=O)c1ccc(NC(=O)c2c(O)[nH]c(=O)[nH]c2=O)cc1 InChI=1S/C16H17N3O6/c1-2-3-8-25-15(23)9-4-6-10(7-5-9)17-12(20)11-13(21)18-16(24)19-14(11)22/h4-7H,2-3,8H2,1H3,(H,17,20)(H3,18,19,21,22,24) MOCMXBAACSSMQG-UHFFFAOYSA-N 46102 4-[(6-hydroxy-2,4-diketo-1H-pyrimidine-5-carbonyl)amino]benzoic acid butyl ester::4-[[(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid butyl ester::UPDDI-00294854::butyl 4-[(6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carbonyl)amino]benzoate::butyl 4-[[6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]carbonylamino]benzoate::cid_16654014 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46102&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654014 252626672 ZINC15952736 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85011 CCOC(=O)c1ccc(NC(=O)c2c(N)n(C)c(=O)n(C)c2=O)cc1 InChI=1S/C16H18N4O5/c1-4-25-15(23)9-5-7-10(8-6-9)18-13(21)11-12(17)19(2)16(24)20(3)14(11)22/h5-8H,4,17H2,1-3H3,(H,18,21) PPMNKMXUHYZQCF-UHFFFAOYSA-N 46103 4-[(4-amino-2,6-diketo-1,3-dimethyl-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::4-[[(4-amino-1,3-dimethyl-2,6-dioxo-5-pyrimidinyl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00294855::cid_16654015::ethyl 4-[(4-amino-1,3-dimethyl-2,6-dioxopyrimidine-5-carbonyl)amino]benzoate::ethyl 4-[[4-azanyl-1,3-dimethyl-2,6-bis(oxidanylidene)pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46103&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654015 252626673 ZINC15952735 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85012 CCOC(=O)c1ccc(NC(=O)c2c(N)n(C)c(=O)[nH]c2=O)cc1 InChI=1S/C15H16N4O5/c1-3-24-14(22)8-4-6-9(7-5-8)17-12(20)10-11(16)19(2)15(23)18-13(10)21/h4-7H,3,16H2,1-2H3,(H,17,20)(H,18,21,23) YFSZKGKXQGJZTO-UHFFFAOYSA-N 46104 4-[(6-amino-2,4-diketo-1-methyl-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::4-[[(6-amino-1-methyl-2,4-dioxo-5-pyrimidinyl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00294856::cid_16654016::ethyl 4-[(6-amino-1-methyl-2,4-dioxopyrimidine-5-carbonyl)amino]benzoate::ethyl 4-[[6-azanyl-1-methyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46104&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654016 252626674 ZINC15952734 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85013 CCOC(=O)c1ccc(NC(=O)c2c(N)n(Cc3ccccc3)c(=O)[nH]c2=O)cc1 InChI=1S/C21H20N4O5/c1-2-30-20(28)14-8-10-15(11-9-14)23-18(26)16-17(22)25(21(29)24-19(16)27)12-13-6-4-3-5-7-13/h3-11H,2,12,22H2,1H3,(H,23,26)(H,24,27,29) PKWHAAZTNXIQMC-UHFFFAOYSA-N 46105 4-[(6-amino-1-benzyl-2,4-diketo-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::4-[[[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00294857::cid_16654017::ethyl 4-[(6-amino-1-benzyl-2,4-dioxopyrimidine-5-carbonyl)amino]benzoate::ethyl 4-[[6-azanyl-2,4-bis(oxidanylidene)-1-(phenylmethyl)pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46105&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654017 252626675 ZINC15952733 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85014 CCOC(=O)c1ccc(NC(=O)c2c(O)[nH]c(=O)[nH]c2=O)cc1 InChI=1S/C14H13N3O6/c1-2-23-13(21)7-3-5-8(6-4-7)15-10(18)9-11(19)16-14(22)17-12(9)20/h3-6H,2H2,1H3,(H,15,18)(H3,16,17,19,20,22) XWZUFKMEGYKBSH-UHFFFAOYSA-N 41765 4-[(6-hydroxy-2,4-diketo-1H-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::4-[[(6-hydroxy-2,4-dioxo-1H-pyrimidin-5-yl)-oxomethyl]amino]benzoic acid ethyl ester::MLS000040367::SMR000058126::cid_662817::ethyl 4-[(6-hydroxy-2,4-dioxo-1H-pyrimidine-5-carbonyl)amino]benzoate::ethyl 4-[[6-oxidanyl-2,4-bis(oxidanylidene)-1H-pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41765&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 662817 252622486 ZINC06499020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85015 Oc1[nH]c(=S)[nH]c(=O)c1C(=O)Nc1ccccc1 InChI=1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18) GFYRZTLCYQQVHZ-UHFFFAOYSA-N 46106 6-hydroxy-4-keto-N-phenyl-2-thioxo-1H-pyrimidine-5-carboxamide::6-hydroxy-4-oxo-N-phenyl-2-sulfanylidene-1H-pyrimidine-5-carboxamide::6-oxidanyl-4-oxidanylidene-N-phenyl-2-sulfanylidene-1H-pyrimidine-5-carboxamide::CHEMBL1765797::UPDDI-00294859::cid_3000671 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46106&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3000671 252626676 CHEMBL1765797 ZINC17128283 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85016 Nc1[nH]c(=O)[nH]c(=O)c1S(=O)(=O)Nc1ccccc1 InChI=1S/C10H10N4O4S/c11-8-7(9(15)13-10(16)12-8)19(17,18)14-6-4-2-1-3-5-6/h1-5,14H,(H4,11,12,13,15,16) OJGXCGDSZVAFTA-UHFFFAOYSA-N 46107 6-amino-2,4-diketo-N-phenyl-1H-pyrimidine-5-sulfonamide::6-amino-2,4-dioxo-N-phenyl-1H-pyrimidine-5-sulfonamide::6-azanyl-2,4-bis(oxidanylidene)-N-phenyl-1H-pyrimidine-5-sulfonamide::UPDDI-00294865::cid_16654019 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46107&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654019 252626677 ZINC15952732 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85017 CCOC(=O)c1cccc(NC(=O)c2c(NCc3ccccc3)[nH]c(=O)[nH]c2=O)c1 InChI=1S/C21H20N4O5/c1-2-30-20(28)14-9-6-10-15(11-14)23-18(26)16-17(24-21(29)25-19(16)27)22-12-13-7-4-3-5-8-13/h3-11H,2,12H2,1H3,(H,23,26)(H3,22,24,25,27,29) XGHHUVPSRIFHKF-UHFFFAOYSA-N 46108 3-[[6-(benzylamino)-2,4-diketo-1H-pyrimidine-5-carbonyl]amino]benzoic acid ethyl ester::3-[[[2,4-dioxo-6-[(phenylmethyl)amino]-1H-pyrimidin-5-yl]-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00294867::cid_16654021::ethyl 3-[[2,4-bis(oxidanylidene)-6-[(phenylmethyl)amino]-1H-pyrimidin-5-yl]carbonylamino]benzoate::ethyl 3-[[6-(benzylamino)-2,4-dioxo-1H-pyrimidine-5-carbonyl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46108&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654021 252626678 ZINC15952730 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85018 COc1ccccc1NS(=O)(=O)c1c(N)[nH]c(=O)[nH]c1=O InChI=1S/C11H12N4O5S/c1-20-7-5-3-2-4-6(7)15-21(18,19)8-9(12)13-11(17)14-10(8)16/h2-5,15H,1H3,(H4,12,13,14,16,17) QJRSLGISKUJFDZ-UHFFFAOYSA-N 46109 6-amino-2,4-diketo-N-(2-methoxyphenyl)-1H-pyrimidine-5-sulfonamide::6-amino-N-(2-methoxyphenyl)-2,4-dioxo-1H-pyrimidine-5-sulfonamide::6-azanyl-N-(2-methoxyphenyl)-2,4-bis(oxidanylidene)-1H-pyrimidine-5-sulfonamide::UPDDI-00294868::cid_16654022 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46109&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654022 252626679 ZINC15952729 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85019 CCOc1ccc(NC(=O)c2c(N)n(C)c(=O)[nH]c2=O)cc1 InChI=1S/C14H16N4O4/c1-3-22-9-6-4-8(5-7-9)16-12(19)10-11(15)18(2)14(21)17-13(10)20/h4-7H,3,15H2,1-2H3,(H,16,19)(H,17,20,21) SYUXFZRTUQCCPQ-UHFFFAOYSA-N 46110 6-amino-2,4-diketo-1-methyl-N-p-phenetyl-pyrimidine-5-carboxamide::6-amino-N-(4-ethoxyphenyl)-1-methyl-2,4-dioxo-5-pyrimidinecarboxamide::6-amino-N-(4-ethoxyphenyl)-1-methyl-2,4-dioxopyrimidine-5-carboxamide::6-azanyl-N-(4-ethoxyphenyl)-1-methyl-2,4-bis(oxidanylidene)pyrimidine-5-carboxamide::UPDDI-00398613::cid_16654907 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46110&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654907 252626680 ZINC15952725 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85020 CCCCOC(=O)c1ccc(NC(=O)c2c(N)n(C)c(=O)[nH]c2=O)cc1 InChI=1S/C17H20N4O5/c1-3-4-9-26-16(24)10-5-7-11(8-6-10)19-14(22)12-13(18)21(2)17(25)20-15(12)23/h5-8H,3-4,9,18H2,1-2H3,(H,19,22)(H,20,23,25) DYSUIJBKNXNWLN-UHFFFAOYSA-N 46111 4-[(6-amino-2,4-diketo-1-methyl-pyrimidine-5-carbonyl)amino]benzoic acid butyl ester::4-[[(6-amino-1-methyl-2,4-dioxo-5-pyrimidinyl)-oxomethyl]amino]benzoic acid butyl ester::UPDDI-00398614::butyl 4-[(6-amino-1-methyl-2,4-dioxopyrimidine-5-carbonyl)amino]benzoate::butyl 4-[[6-azanyl-1-methyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]carbonylamino]benzoate::cid_16654908 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46111&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654908 252626681 ZINC15952724 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85021 CCOC(=O)c1ccccc1NC(=O)c1c(N)n(C)c(=O)[nH]c1=O InChI=1S/C15H16N4O5/c1-3-24-14(22)8-6-4-5-7-9(8)17-12(20)10-11(16)19(2)15(23)18-13(10)21/h4-7H,3,16H2,1-2H3,(H,17,20)(H,18,21,23) MNWKITPUGKRNMN-UHFFFAOYSA-N 46112 2-[(6-amino-2,4-diketo-1-methyl-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::2-[[(6-amino-1-methyl-2,4-dioxo-5-pyrimidinyl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00398615::cid_16654909::ethyl 2-[(6-amino-1-methyl-2,4-dioxopyrimidine-5-carbonyl)amino]benzoate::ethyl 2-[[6-azanyl-1-methyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46112&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654909 252626682 ZINC15952723 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85022 Cn1c(N)c(C(=O)Nc2ccccc2)c(=O)[nH]c1=O InChI=1S/C12H12N4O3/c1-16-9(13)8(11(18)15-12(16)19)10(17)14-7-5-3-2-4-6-7/h2-6H,13H2,1H3,(H,14,17)(H,15,18,19) HRFIEXOWZSBDIP-UHFFFAOYSA-N 46113 6-amino-1-methyl-2,4-dioxo-N-phenyl-5-pyrimidinecarboxamide::6-amino-1-methyl-2,4-dioxo-N-phenylpyrimidine-5-carboxamide::6-amino-2,4-diketo-1-methyl-N-phenyl-pyrimidine-5-carboxamide::6-azanyl-1-methyl-2,4-bis(oxidanylidene)-N-phenyl-pyrimidine-5-carboxamide::UPDDI-00398616::cid_16654910 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46113&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654910 252626683 ZINC15952722 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85023 CCOC(=O)c1cccc(NC(=O)c2c(N)n(C)c(=O)[nH]c2=O)c1 InChI=1S/C15H16N4O5/c1-3-24-14(22)8-5-4-6-9(7-8)17-12(20)10-11(16)19(2)15(23)18-13(10)21/h4-7H,3,16H2,1-2H3,(H,17,20)(H,18,21,23) WHVGDBRUYDVZMC-UHFFFAOYSA-N 46114 3-[(6-amino-2,4-diketo-1-methyl-pyrimidine-5-carbonyl)amino]benzoic acid ethyl ester::3-[[(6-amino-1-methyl-2,4-dioxo-5-pyrimidinyl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00398617::cid_16654911::ethyl 3-[(6-amino-1-methyl-2,4-dioxopyrimidine-5-carbonyl)amino]benzoate::ethyl 3-[[6-azanyl-1-methyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46114&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654911 252626684 ZINC15952721 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85024 CCOC(=O)c1ccc(NC(=O)c2c(NCc3ccccc3)[nH]c(=O)[nH]c2=O)cc1 InChI=1S/C21H20N4O5/c1-2-30-20(28)14-8-10-15(11-9-14)23-18(26)16-17(24-21(29)25-19(16)27)22-12-13-6-4-3-5-7-13/h3-11H,2,12H2,1H3,(H,23,26)(H3,22,24,25,27,29) XENUFLWSZPGHKS-UHFFFAOYSA-N 46115 4-[[6-(benzylamino)-2,4-diketo-1H-pyrimidine-5-carbonyl]amino]benzoic acid ethyl ester::4-[[[2,4-dioxo-6-[(phenylmethyl)amino]-1H-pyrimidin-5-yl]-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00398618::cid_16654912::ethyl 4-[[2,4-bis(oxidanylidene)-6-[(phenylmethyl)amino]-1H-pyrimidin-5-yl]carbonylamino]benzoate::ethyl 4-[[6-(benzylamino)-2,4-dioxo-1H-pyrimidine-5-carbonyl]amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46115&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16654912 252626685 ZINC15952720 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85025 Cn1c(N)c(c(=O)n(C)c1=O)S(=O)(=O)NCc1ccccc1 InChI=1S/C13H16N4O4S/c1-16-11(14)10(12(18)17(2)13(16)19)22(20,21)15-8-9-6-4-3-5-7-9/h3-7,15H,8,14H2,1-2H3 MPNWDQPKYPXORV-UHFFFAOYSA-N 46116 4-amino-1,3-dimethyl-2,6-dioxo-N-(phenylmethyl)-5-pyrimidinesulfonamide::4-amino-N-benzyl-1,3-dimethyl-2,6-dioxopyrimidine-5-sulfonamide::4-amino-N-benzyl-2,6-diketo-1,3-dimethyl-pyrimidine-5-sulfonamide::4-azanyl-1,3-dimethyl-2,6-bis(oxidanylidene)-N-(phenylmethyl)pyrimidine-5-sulfonamide::UPDDI-00398619::cid_7197655 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46116&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7197655 252626686 ZINC04339422 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85026 CCOC(=O)CCCCCNC(=O)C1C(=O)NC(=O)NC1=O InChI=1S/C13H19N3O6/c1-2-22-8(17)6-4-3-5-7-14-10(18)9-11(19)15-13(21)16-12(9)20/h9H,2-7H2,1H3,(H,14,18)(H2,15,16,19,20,21) ADWBLTOOXJXSBG-UHFFFAOYSA-N 46117 6-[[hydroxy-(2,4,6-triketohexahydropyrimidin-5-ylidene)methyl]amino]hexanoic acid ethyl ester::6-[[hydroxy-(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]amino]hexanoic acid ethyl ester::UPDDI-00398620::cid_16760234::ethyl 6-[[hydroxy-(2,4,6-trioxo-1,3-diazinan-5-ylidene)methyl]amino]hexanoate::ethyl 6-[[oxidanyl-[2,4,6-tris(oxidanylidene)-1,3-diazinan-5-ylidene]methyl]amino]hexanoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46117&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91896675 252626687 ZINC15952228 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85027 Cc1cccc(NNC=C2C(=O)NC(=S)NC2=O)c1 InChI=1S/C12H12N4O2S/c1-7-3-2-4-8(5-7)16-13-6-9-10(17)14-12(19)15-11(9)18/h2-6,13,16H,1H3,(H2,14,15,17,18,19) OHZNVMMFOAYZRC-UHFFFAOYSA-N 46118 5-[[(3-methylphenyl)hydrazo]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione::5-[[2-(3-methylphenyl)hydrazinyl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione::5-[[N'-(m-tolyl)hydrazino]methylene]-2-thioxo-hexahydropyrimidine-4,6-quinone::UPDDI-00398621::cid_5401241 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46118&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5401241 252626688 ZINC00221579 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85028 CC(NNC(=O)c1ccncc1)=C1C(=O)NC(=O)NC1=O InChI=1S/C12H11N5O4/c1-6(8-10(19)14-12(21)15-11(8)20)16-17-9(18)7-2-4-13-5-3-7/h2-5,16H,1H3,(H,17,18)(H2,14,15,19,20,21) XCYMVZFCQOSHRS-UHFFFAOYSA-N 46119 N'-[1-(2,4,6-triketohexahydropyrimidin-5-ylidene)ethyl]isonicotinohydrazide::N'-[1-(2,4,6-trioxo-1,3-diazinan-5-ylidene)ethyl]-4-pyridinecarbohydrazide::N'-[1-(2,4,6-trioxo-1,3-diazinan-5-ylidene)ethyl]pyridine-4-carbohydrazide::N'-[1-[2,4,6-tris(oxidanylidene)-1,3-diazinan-5-ylidene]ethyl]pyridine-4-carbohydrazide::UPDDI-00398622::cid_5390768 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46119&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5390768 252626689 ZINC08968748 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85029 CCOC(=O)c1ccc(NC(=O)c2ccc(F)cc2F)cc1 InChI=1S/C16H13F2NO3/c1-2-22-16(21)10-3-6-12(7-4-10)19-15(20)13-8-5-11(17)9-14(13)18/h3-9H,2H2,1H3,(H,19,20) WDRGIYSOKQFHPY-UHFFFAOYSA-N 46120 4-[(2,4-difluorobenzoyl)amino]benzoic acid ethyl ester::4-[[(2,4-difluorophenyl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00398623::cid_7760420::ethyl 4-[(2,4-difluorobenzoyl)amino]benzoate::ethyl 4-[[2,4-bis(fluoranyl)phenyl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46120&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7760420 252626690 ZINC05636878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85030 Fc1ccc(C(=O)Nc2ccccc2)c(F)c1 InChI=1S/C13H9F2NO/c14-9-6-7-11(12(15)8-9)13(17)16-10-4-2-1-3-5-10/h1-8H,(H,16,17) UOKDUAZIONZFCP-UHFFFAOYSA-N 46121 2,4-bis(fluoranyl)-N-phenyl-benzamide::2,4-difluoro-N-phenyl-benzamide::2,4-difluoro-N-phenylbenzamide::UPDDI-00398624::cid_7732868 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7732868 252626691 ZINC05558204 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85031 Cc1ccc(NC(=O)c2ccc(F)cc2F)cc1 InChI=1S/C14H11F2NO/c1-9-2-5-11(6-3-9)17-14(18)12-7-4-10(15)8-13(12)16/h2-8H,1H3,(H,17,18) UJUNEZBQMKQLAE-UHFFFAOYSA-N 46122 2,4-bis(fluoranyl)-N-(4-methylphenyl)benzamide::2,4-difluoro-N-(4-methylphenyl)benzamide::2,4-difluoro-N-(p-tolyl)benzamide::UPDDI-00398625::cid_2989285 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46122&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2989285 252626692 ZINC04856899 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85032 CCOC(=O)CCCCCNC(=O)c1ccc(F)cc1F InChI=1S/C15H19F2NO3/c1-2-21-14(19)6-4-3-5-9-18-15(20)12-8-7-11(16)10-13(12)17/h7-8,10H,2-6,9H2,1H3,(H,18,20) LXFJDVSZVWHKHH-UHFFFAOYSA-N 46123 6-[(2,4-difluorobenzoyl)amino]hexanoic acid ethyl ester::6-[[(2,4-difluorophenyl)-oxomethyl]amino]hexanoic acid ethyl ester::UPDDI-00398626::cid_23581831::ethyl 6-[(2,4-difluorobenzoyl)amino]hexanoate::ethyl 6-[[2,4-bis(fluoranyl)phenyl]carbonylamino]hexanoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46123&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 23581831 252626693 ZINC12727185 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85033 CCOc1ccc(NC(=O)c2ccc(F)cc2F)cc1 InChI=1S/C15H13F2NO2/c1-2-20-12-6-4-11(5-7-12)18-15(19)13-8-3-10(16)9-14(13)17/h3-9H,2H2,1H3,(H,18,19) QIZDAQGDNGATPS-UHFFFAOYSA-N 46124 2,4-difluoro-N-p-phenetyl-benzamide::N-(4-ethoxyphenyl)-2,4-bis(fluoranyl)benzamide::N-(4-ethoxyphenyl)-2,4-difluorobenzamide::UPDDI-00398627::cid_7733204 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46124&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7733204 252626694 ZINC05558831 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85034 CCOC(=O)c1ccccc1NC(=O)c1ccc(F)cc1F InChI=1S/C16H13F2NO3/c1-2-22-16(21)12-5-3-4-6-14(12)19-15(20)11-8-7-10(17)9-13(11)18/h3-9H,2H2,1H3,(H,19,20) PTERUTYJQIWLFB-UHFFFAOYSA-N 46125 2-[(2,4-difluorobenzoyl)amino]benzoic acid ethyl ester::2-[[(2,4-difluorophenyl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00398628::cid_7768345::ethyl 2-[(2,4-difluorobenzoyl)amino]benzoate::ethyl 2-[[2,4-bis(fluoranyl)phenyl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46125&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7768345 252626695 ZINC05672326 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85035 CCOC(=O)c1cccc(NC(=O)c2ccc(F)cc2F)c1 InChI=1S/C16H13F2NO3/c1-2-22-16(21)10-4-3-5-12(8-10)19-15(20)13-7-6-11(17)9-14(13)18/h3-9H,2H2,1H3,(H,19,20) QZDCWOPSLKKKET-UHFFFAOYSA-N 46126 3-[(2,4-difluorobenzoyl)amino]benzoic acid ethyl ester::3-[[(2,4-difluorophenyl)-oxomethyl]amino]benzoic acid ethyl ester::UPDDI-00398629::cid_9048209::ethyl 3-[(2,4-difluorobenzoyl)amino]benzoate::ethyl 3-[[2,4-bis(fluoranyl)phenyl]carbonylamino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46126&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9048209 252626696 ZINC07922643 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 85036 CCCCOC(=O)c1ccc(NC(=O)c2ccc(F)cc2F)cc1 InChI=1S/C18H17F2NO3/c1-2-3-10-24-18(23)12-4-7-14(8-5-12)21-17(22)15-9-6-13(19)11-16(15)20/h4-9,11H,2-3,10H2,1H3,(H,21,22) MSRUJIZBTMYBHB-UHFFFAOYSA-N 46127 4-[(2,4-difluorobenzoyl)amino]benzoic acid butyl ester::4-[[(2,4-difluorophenyl)-oxomethyl]amino]benzoic acid butyl ester::UPDDI-00398630::butyl 4-[(2,4-difluorobenzoyl)amino]benzoate::butyl 4-[[2,4-bis(fluoranyl)phenyl]carbonylamino]benzoate::cid_7760837 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 PubChem 10.7270/Q280511V aid1057 PubChem, PC University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46127&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7760837 252626697 ZINC05637516 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187020 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20?,21+/m1/s1 UIYQCJDQBRUFEV-RVLREDAYSA-N 86318 Phosphodiester analog, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 3.6e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86318&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340542 136352418 ZINC96135278 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187021 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CP(O)(O)=O)C(N)=O InChI=1S/C27H45N8O10P/c1-14(2)8-18(32-27(42)21-6-5-7-35(21)16(4)37)24(39)31-19(9-17-10-29-13-30-17)25(40)33-20(11-36)26(41)34-22(23(28)38)15(3)12-46(43,44)45/h10,13-15,18-22,36H,5-9,11-12H2,1-4H3,(H2,28,38)(H,29,30)(H,31,39)(H,32,42)(H,33,40)(H,34,41)(H2,43,44,45)/t15-,18-,19-,20-,21?,22-/m0/s1 YTMVXDCWMDKJNJ-FKFWJTAYSA-N 86319 Phosphodiester analog, 2 Serine/threonine-protein kinase PLK1 Homo sapiens 1.74e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86319&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340543 136352419 ZINC96135280 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187022 COP(O)(=O)O[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)C1CCCN1C(C)=O)C(N)=O InChI=1S/C27H45N8O11P/c1-14(2)9-18(32-27(42)21-7-6-8-35(21)16(4)37)24(39)31-19(10-17-11-29-13-30-17)25(40)33-20(12-36)26(41)34-22(23(28)38)15(3)46-47(43,44)45-5/h11,13-15,18-22,36H,6-10,12H2,1-5H3,(H2,28,38)(H,29,30)(H,31,39)(H,32,42)(H,33,40)(H,34,41)(H,43,44)/t15-,18+,19+,20+,21?,22+/m1/s1 RNCRVNDDHMEZSP-UJXMJKKGSA-N 86320 Phosphodiester analog, 3a Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86320&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340544 136352420 ZINC96135282 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187023 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCC[C@@H](O)CO)C(N)=O InChI=1S/C30H51N8O13P/c1-16(2)10-21(35-30(47)24-6-5-8-38(24)18(4)41)27(44)34-22(11-19-12-32-15-33-19)28(45)36-23(14-40)29(46)37-25(26(31)43)17(3)51-52(48,49)50-9-7-20(42)13-39/h12,15-17,20-25,39-40,42H,5-11,13-14H2,1-4H3,(H2,31,43)(H,32,33)(H,34,44)(H,35,47)(H,36,45)(H,37,46)(H,48,49)/t17-,20-,21+,22+,23+,24?,25+/m1/s1 UYSJWPOXNXNPPW-BNQRVOKJSA-N 86321 Phosphodiester analog, 3b Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86321&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340545 136352421 ZINC96135284 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187024 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCC(O)=O)C(N)=O InChI=1S/C29H47N8O13P/c1-15(2)10-19(34-29(46)22-6-5-8-37(22)17(4)39)26(43)33-20(11-18-12-31-14-32-18)27(44)35-21(13-38)28(45)36-24(25(30)42)16(3)50-51(47,48)49-9-7-23(40)41/h12,14-16,19-22,24,38H,5-11,13H2,1-4H3,(H2,30,42)(H,31,32)(H,33,43)(H,34,46)(H,35,44)(H,36,45)(H,40,41)(H,47,48)/t16-,19+,20+,21+,22?,24+/m1/s1 NAXRKJFAFVPMSY-WOPOHTITSA-N 86322 Phosphodiester analog, 3c Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86322&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340546 136352422 ZINC96135286 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187025 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCC=C)C(N)=O InChI=1S/C32H53N8O11P/c1-6-7-8-9-13-50-52(48,49)51-20(4)27(28(33)43)39-31(46)25(17-41)38-30(45)24(15-22-16-34-18-35-22)36-29(44)23(14-19(2)3)37-32(47)26-11-10-12-40(26)21(5)42/h6,16,18-20,23-27,41H,1,7-15,17H2,2-5H3,(H2,33,43)(H,34,35)(H,36,44)(H,37,47)(H,38,45)(H,39,46)(H,48,49)/t20-,23+,24+,25+,26?,27+/m1/s1 ZBXKNMAVTNZVRH-BTERBCMISA-N 86323 Phosphodiester analog, 3d Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86323&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340547 136352423 ZINC96135288 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187026 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCc1cccs1)C(N)=O InChI=1S/C32H49N8O11PS/c1-18(2)13-23(37-32(47)26-8-5-10-40(26)20(4)42)29(44)36-24(14-21-15-34-17-35-21)30(45)38-25(16-41)31(46)39-27(28(33)43)19(3)51-52(48,49)50-11-9-22-7-6-12-53-22/h6-7,12,15,17-19,23-27,41H,5,8-11,13-14,16H2,1-4H3,(H2,33,43)(H,34,35)(H,36,44)(H,37,47)(H,38,45)(H,39,46)(H,48,49)/t19-,23+,24+,25+,26?,27+/m1/s1 HXIUCWISPKIWNQ-JNHICRFPSA-N 86324 Phosphodiester analog, 3e Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86324&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340548 136352424 ZINC96135290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187027 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCc1ccccc1)C(N)=O InChI=1S/C36H55N8O11P/c1-22(2)17-27(41-36(51)30-14-10-15-44(30)24(4)46)33(48)40-28(18-26-19-38-21-39-26)34(49)42-29(20-45)35(50)43-31(32(37)47)23(3)55-56(52,53)54-16-9-8-13-25-11-6-5-7-12-25/h5-7,11-12,19,21-23,27-31,45H,8-10,13-18,20H2,1-4H3,(H2,37,47)(H,38,39)(H,40,48)(H,41,51)(H,42,49)(H,43,50)(H,52,53)/t23-,27+,28+,29+,30?,31+/m1/s1 LOJFMYRCLHOKQW-MNRWRCHBSA-N 86325 Phosphodiester analog, 3f Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86325&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340549 136352425 ZINC96135292 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187028 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCCc1ccccc1)C(N)=O InChI=1S/C37H57N8O11P/c1-23(2)18-28(42-37(52)31-15-11-16-45(31)25(4)47)34(49)41-29(19-27-20-39-22-40-27)35(50)43-30(21-46)36(51)44-32(33(38)48)24(3)56-57(53,54)55-17-10-6-9-14-26-12-7-5-8-13-26/h5,7-8,12-13,20,22-24,28-32,46H,6,9-11,14-19,21H2,1-4H3,(H2,38,48)(H,39,40)(H,41,49)(H,42,52)(H,43,50)(H,44,51)(H,53,54)/t24-,28+,29+,30+,31?,32+/m1/s1 YZCJZZJOTSKOOG-UYZHSQLPSA-N 86326 Phosphodiester analog, 3g Serine/threonine-protein kinase PLK1 Homo sapiens 2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86326&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340550 136352426 ZINC96135294 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187029 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCCCc1ccccc1)C(N)=O InChI=1S/C38H59N8O11P/c1-24(2)19-29(43-38(53)32-16-12-17-46(32)26(4)48)35(50)42-30(20-28-21-40-23-41-28)36(51)44-31(22-47)37(52)45-33(34(39)49)25(3)57-58(54,55)56-18-11-6-5-8-13-27-14-9-7-10-15-27/h7,9-10,14-15,21,23-25,29-33,47H,5-6,8,11-13,16-20,22H2,1-4H3,(H2,39,49)(H,40,41)(H,42,50)(H,43,53)(H,44,51)(H,45,52)(H,54,55)/t25-,29+,30+,31+,32?,33+/m1/s1 SBGBHYLOJBYEOQ-STMKAHLYSA-N 86327 Phosphodiester analog, 3h Serine/threonine-protein kinase PLK1 Homo sapiens 6.6e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86327&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340551 136352427 ZINC96135296 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187030 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCCCCc1ccccc1)C(N)=O InChI=1S/C39H61N8O11P/c1-25(2)20-30(44-39(54)33-17-13-18-47(33)27(4)49)36(51)43-31(21-29-22-41-24-42-29)37(52)45-32(23-48)38(53)46-34(35(40)50)26(3)58-59(55,56)57-19-12-7-5-6-9-14-28-15-10-8-11-16-28/h8,10-11,15-16,22,24-26,30-34,48H,5-7,9,12-14,17-21,23H2,1-4H3,(H2,40,50)(H,41,42)(H,43,51)(H,44,54)(H,45,52)(H,46,53)(H,55,56)/t26-,30+,31+,32+,33?,34+/m1/s1 BONBKQMNHLFAPR-RLFHXNPXSA-N 86328 Phosphodiester analog, 3i Serine/threonine-protein kinase PLK1 Homo sapiens 9.4e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86328&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340552 136352428 ZINC96135298 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187031 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCCCCCc1ccccc1)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(45-40(55)34-18-14-19-48(34)28(4)50)37(52)44-32(22-30-23-42-25-43-30)38(53)46-33(24-49)39(54)47-35(36(41)51)27(3)59-60(56,57)58-20-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,42,43)(H,44,52)(H,45,55)(H,46,53)(H,47,54)(H,56,57)/t27-,31+,32+,33+,34?,35+/m1/s1 IESCWQACEJMXNA-XKSQAVIKSA-N 86329 Phosphodiester analog, 3j Serine/threonine-protein kinase PLK1 Homo sapiens 1.1e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86329&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340553 136352429 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187032 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCCCCCCc1ccccc1)C(N)=O InChI=1S/C41H65N8O11P/c1-27(2)22-32(46-41(56)35-19-15-20-49(35)29(4)51)38(53)45-33(23-31-24-43-26-44-31)39(54)47-34(25-50)40(55)48-36(37(42)52)28(3)60-61(57,58)59-21-14-9-7-5-6-8-11-16-30-17-12-10-13-18-30/h10,12-13,17-18,24,26-28,32-36,50H,5-9,11,14-16,19-23,25H2,1-4H3,(H2,42,52)(H,43,44)(H,45,53)(H,46,56)(H,47,54)(H,48,55)(H,57,58)/t28-,32+,33+,34+,35?,36+/m1/s1 AQYBAPNCJNYOST-GQCOGFELSA-N 86330 Phosphodiester analog, 3k Serine/threonine-protein kinase PLK1 Homo sapiens 1.54e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86330&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340554 136352430 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187033 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(=O)OCCCCCCCCCCc1ccccc1)C(N)=O InChI=1S/C42H67N8O11P/c1-28(2)23-33(47-42(57)36-20-16-21-50(36)30(4)52)39(54)46-34(24-32-25-44-27-45-32)40(55)48-35(26-51)41(56)49-37(38(43)53)29(3)61-62(58,59)60-22-15-10-8-6-5-7-9-12-17-31-18-13-11-14-19-31/h11,13-14,18-19,25,27-29,33-37,51H,5-10,12,15-17,20-24,26H2,1-4H3,(H2,43,53)(H,44,45)(H,46,54)(H,47,57)(H,48,55)(H,49,56)(H,58,59)/t29-,33+,34+,35+,36?,37+/m1/s1 SGVVYCXQGHQVPU-YRCADNCLSA-N 86331 Phosphodiester analog, 3l Serine/threonine-protein kinase PLK1 Homo sapiens 7.0e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86331&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340555 136352431 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187034 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C27H45N8O11P/c1-14(2)9-18(31-27(42)21-7-6-8-35(21)16(4)37)24(39)30-19(10-17-11-29-13-34(17)5)25(40)32-20(12-36)26(41)33-22(23(28)38)15(3)46-47(43,44)45/h11,13-15,18-22,36H,6-10,12H2,1-5H3,(H2,28,38)(H,30,39)(H,31,42)(H,32,40)(H,33,41)(H2,43,44,45)/t15-,18+,19+,20+,21?,22+/m1/s1 GBOOEUPTQRPPTD-UJXMJKKGSA-N 86332 Phosphodiester analog, 4a Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86332&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340556 136352432 ZINC96135300 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187035 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CC[C@@H](O)CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C30H51N8O13P/c1-16(2)10-21(34-30(47)24-6-5-8-38(24)18(4)41)27(44)33-22(11-19-12-32-15-37(19)9-7-20(42)13-39)28(45)35-23(14-40)29(46)36-25(26(31)43)17(3)51-52(48,49)50/h12,15-17,20-25,39-40,42H,5-11,13-14H2,1-4H3,(H2,31,43)(H,33,44)(H,34,47)(H,35,45)(H,36,46)(H2,48,49,50)/t17-,20-,21+,22+,23+,24?,25+/m1/s1 RVVPKSOFQSHTSB-BNQRVOKJSA-N 86333 Phosphodiester analog, 4b Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86333&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340557 136352433 ZINC96135302 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187036 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C29H47N8O13P/c1-15(2)10-19(33-29(46)22-6-5-8-37(22)17(4)39)26(43)32-20(11-18-12-31-14-36(18)9-7-23(40)41)27(44)34-21(13-38)28(45)35-24(25(30)42)16(3)50-51(47,48)49/h12,14-16,19-22,24,38H,5-11,13H2,1-4H3,(H2,30,42)(H,32,43)(H,33,46)(H,34,44)(H,35,45)(H,40,41)(H2,47,48,49)/t16-,19+,20+,21+,22?,24+/m1/s1 UOWPAXBNJWXYPX-WOPOHTITSA-N 86334 Phosphodiester analog, 4c Serine/threonine-protein kinase PLK1 Homo sapiens >2.00e+5 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86334&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340558 136352434 ZINC96135304 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187037 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCC=C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C32H53N8O11P/c1-6-7-8-9-12-39-18-34-16-22(39)15-24(30(45)37-25(17-41)31(46)38-27(28(33)43)20(4)51-52(48,49)50)35-29(44)23(14-19(2)3)36-32(47)26-11-10-13-40(26)21(5)42/h6,16,18-20,23-27,41H,1,7-15,17H2,2-5H3,(H2,33,43)(H,35,44)(H,36,47)(H,37,45)(H,38,46)(H2,48,49,50)/t20-,23+,24+,25+,26?,27+/m1/s1 PIKWHOQEGNBZSH-BTERBCMISA-N 86335 Phosphodiester analog, 4d Serine/threonine-protein kinase PLK1 Homo sapiens 3.5e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86335&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340559 136352435 ZINC96135306 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187038 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C32H49N8O11PS/c1-18(2)13-23(36-32(47)26-8-5-10-40(26)20(4)42)29(44)35-24(14-21-15-34-17-39(21)11-9-22-7-6-12-53-22)30(45)37-25(16-41)31(46)38-27(28(33)43)19(3)51-52(48,49)50/h6-7,12,15,17-19,23-27,41H,5,8-11,13-14,16H2,1-4H3,(H2,33,43)(H,35,44)(H,36,47)(H,37,45)(H,38,46)(H2,48,49,50)/t19-,23+,24+,25+,26?,27+/m1/s1 JUJFZBMIVCEVOI-JNHICRFPSA-N 86336 Phosphodiester analog, 4e Serine/threonine-protein kinase PLK1 Homo sapiens 1.9e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86336&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340560 136352436 ZINC96135308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187039 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C36H55N8O11P/c1-22(2)17-27(40-36(51)30-14-10-16-44(30)24(4)46)33(48)39-28(18-26-19-38-21-43(26)15-9-8-13-25-11-6-5-7-12-25)34(49)41-29(20-45)35(50)42-31(32(37)47)23(3)55-56(52,53)54/h5-7,11-12,19,21-23,27-31,45H,8-10,13-18,20H2,1-4H3,(H2,37,47)(H,39,48)(H,40,51)(H,41,49)(H,42,50)(H2,52,53,54)/t23-,27+,28+,29+,30?,31+/m1/s1 CMLKAEFZWPFASO-MNRWRCHBSA-N 86337 Phosphodiester analog, 4f Serine/threonine-protein kinase PLK1 Homo sapiens 1.1e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86337&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340561 136352437 ZINC96135310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187040 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C37H57N8O11P/c1-23(2)18-28(41-37(52)31-15-11-17-45(31)25(4)47)34(49)40-29(19-27-20-39-22-44(27)16-10-6-9-14-26-12-7-5-8-13-26)35(50)42-30(21-46)36(51)43-32(33(38)48)24(3)56-57(53,54)55/h5,7-8,12-13,20,22-24,28-32,46H,6,9-11,14-19,21H2,1-4H3,(H2,38,48)(H,40,49)(H,41,52)(H,42,50)(H,43,51)(H2,53,54,55)/t24-,28+,29+,30+,31?,32+/m1/s1 IEPRBCWKRWZIIB-UYZHSQLPSA-N 86338 Phosphodiester analog, 4g Serine/threonine-protein kinase PLK1 Homo sapiens 4e+3 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86338&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340562 136352438 ZINC96135312 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187041 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C38H59N8O11P/c1-24(2)19-29(42-38(53)32-16-12-18-46(32)26(4)48)35(50)41-30(20-28-21-40-23-45(28)17-11-6-5-8-13-27-14-9-7-10-15-27)36(51)43-31(22-47)37(52)44-33(34(39)49)25(3)57-58(54,55)56/h7,9-10,14-15,21,23-25,29-33,47H,5-6,8,11-13,16-20,22H2,1-4H3,(H2,39,49)(H,41,50)(H,42,53)(H,43,51)(H,44,52)(H2,54,55,56)/t25-,29+,30+,31+,32?,33+/m1/s1 COWIGBIUFSUYDX-STMKAHLYSA-N 86339 Phosphodiester analog, 4h Serine/threonine-protein kinase PLK1 Homo sapiens 55 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86339&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340563 136352439 ZINC96135314 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187042 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C39H61N8O11P/c1-25(2)20-30(43-39(54)33-17-13-19-47(33)27(4)49)36(51)42-31(37(52)44-32(23-48)38(53)45-34(35(40)50)26(3)58-59(55,56)57)21-29-22-41-24-46(29)18-12-7-5-6-9-14-28-15-10-8-11-16-28/h8,10-11,15-16,22,24-26,30-34,48H,5-7,9,12-14,17-21,23H2,1-4H3,(H2,40,50)(H,42,51)(H,43,54)(H,44,52)(H,45,53)(H2,55,56,57)/t26-,30+,31+,32+,33?,34+/m1/s1 IVSQIAOFFYRIMG-RLFHXNPXSA-N 86340 Phosphodiester analog, 4i Serine/threonine-protein kinase PLK1 Homo sapiens 1.2e+2 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86340&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340564 136352440 ZINC96135316 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187043 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34?,35+/m1/s1 ZDQJNYLFGPXANH-XKSQAVIKSA-N 86341 Phosphodiester analog, 4j::Phosphodiester analog, 4j (S4A) Serine/threonine-protein kinase PLK1 Homo sapiens 17 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86341&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340565 136352441 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187044 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C41H65N8O11P/c1-27(2)22-32(45-41(56)35-19-15-21-49(35)29(4)51)38(53)44-33(39(54)46-34(25-50)40(55)47-36(37(42)52)28(3)60-61(57,58)59)23-31-24-43-26-48(31)20-14-9-7-5-6-8-11-16-30-17-12-10-13-18-30/h10,12-13,17-18,24,26-28,32-36,50H,5-9,11,14-16,19-23,25H2,1-4H3,(H2,42,52)(H,44,53)(H,45,56)(H,46,54)(H,47,55)(H2,57,58,59)/t28-,32+,33+,34+,35?,36+/m1/s1 CILUQLJTUHCLJF-GQCOGFELSA-N 86342 Phosphodiester analog, 4k Serine/threonine-protein kinase PLK1 Homo sapiens 1.0e+2 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86342&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340566 136352442 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187045 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C42H67N8O11P/c1-28(2)23-33(46-42(57)36-20-16-22-50(36)30(4)52)39(54)45-34(40(55)47-35(26-51)41(56)48-37(38(43)53)29(3)61-62(58,59)60)24-32-25-44-27-49(32)21-15-10-8-6-5-7-9-12-17-31-18-13-11-14-19-31/h11,13-14,18-19,25,27-29,33-37,51H,5-10,12,15-17,20-24,26H2,1-4H3,(H2,43,53)(H,45,54)(H,46,57)(H,47,55)(H,48,56)(H2,58,59,60)/t29-,33+,34+,35+,36?,37+/m1/s1 MSXHTSCTBPCKQJ-YRCADNCLSA-N 86343 Phosphodiester analog, 4l Serine/threonine-protein kinase PLK1 Homo sapiens 1.3e+2 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86343&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340567 136352443 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187046 COCCOCCOCCOCCOCCOCCOCCOCCC(=O)N1CCCC1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CP(O)(O)=O)C(N)=O InChI=1S/C43H77N8O18P/c1-30(2)24-33(40(55)47-34(25-32-26-45-29-46-32)41(56)49-35(27-52)42(57)50-38(39(44)54)31(3)28-70(59,60)61)48-43(58)36-6-5-8-51(36)37(53)7-9-63-12-13-65-16-17-67-20-21-69-23-22-68-19-18-66-15-14-64-11-10-62-4/h26,29-31,33-36,38,52H,5-25,27-28H2,1-4H3,(H2,44,54)(H,45,46)(H,47,55)(H,48,58)(H,49,56)(H,50,57)(H2,59,60,61)/t31-,33-,34-,35-,36?,38-/m0/s1 MWAIALWPYZDKQO-YQSJLYDYSA-N 86344 Phosphodiester analog, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 4.5e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86344&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340568 136352444 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187047 COCCOCCOCCOCCOCCOCCOCCOCCC(=O)N1CCCC1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CP(O)(O)=O)C(N)=O InChI=1S/C57H97N8O18P/c1-43(2)37-47(61-57(72)50-18-14-21-65(50)51(67)19-22-77-25-26-79-29-30-81-33-34-83-36-35-82-32-31-80-28-27-78-24-23-76-4)54(69)60-48(55(70)62-49(40-66)56(71)63-52(53(58)68)44(3)41-84(73,74)75)38-46-39-59-42-64(46)20-13-8-6-5-7-10-15-45-16-11-9-12-17-45/h9,11-12,16-17,39,42-44,47-50,52,66H,5-8,10,13-15,18-38,40-41H2,1-4H3,(H2,58,68)(H,60,69)(H,61,72)(H,62,70)(H,63,71)(H2,73,74,75)/t44-,47-,48-,49-,50?,52-/m0/s1 WLTDRCJNNFNMFV-KRFCXPEQSA-N 86345 Phosphodiester analog, 6::Phosphodiester analog, 6(S4A) Serine/threonine-protein kinase PLK1 Homo sapiens 3e+1 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86345&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340569 136352445 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187048 COCCOCCOCCOCCOCCOCCOCCOCCC(=O)N1CCCC1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CP(O)(O)=O)C(N)=O InChI=1S/C57H97N8O18P/c1-43(2)37-47(61-57(72)50-18-14-21-65(50)51(67)19-22-77-25-26-79-29-30-81-33-34-83-36-35-82-32-31-80-28-27-78-24-23-76-4)54(69)60-48(55(70)62-49(40-66)56(71)63-52(53(58)68)44(3)41-84(73,74)75)38-46-39-59-42-64(46)20-13-8-6-5-7-10-15-45-16-11-9-12-17-45/h9,11-12,16-17,39,42-44,47-50,52,66H,5-8,10,13-15,18-38,40-41H2,1-4H3,(H2,58,68)(H,60,69)(H,61,72)(H,62,70)(H,63,71)(H2,73,74,75)/t44-,47-,48-,49-,50?,52-/m0/s1 WLTDRCJNNFNMFV-KRFCXPEQSA-N 86345 Phosphodiester analog, 6::Phosphodiester analog, 6(S4A) Serine/threonine-protein kinase PLK1 Homo sapiens 9e+3 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86345&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340569 136352445 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 187049 CC(C)C[C@H](NC(=O)C1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34?,35+/m1/s1 ZDQJNYLFGPXANH-XKSQAVIKSA-N 86341 Phosphodiester analog, 4j::Phosphodiester analog, 4j (S4A) Serine/threonine-protein kinase PLK1 Homo sapiens 1.2e+4 8 25.00 C Curated from the literature by BindingDB 10.1038/nchembio.614 10.7270/Q2CN72GB 21765407 aid1799699 Liu, F; Park, JE; Qian, WJ; Lim, D; Gräber, M; Berg, T; Yaffe, MB; Lee, KS; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86341&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340565 136352441 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 191702 COc1ccc(cc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O)N1CCN(C)CC1 InChI=1S/C22H19F3N4O4/c1-12-16(13(2)33-28-12)10-29-17-5-4-15(7-18(17)32-11-20(29)30)21(31)27-9-14-3-6-19(26-8-14)22(23,24)25/h3-8H,9-11H2,1-2H3,(H,27,31) IZHDJXVLMSZONH-UHFFFAOYSA-N 41575 CHEMBL1094408::US8614220, A85B1C1Z Serine/threonine-protein kinase PLK1 Homo sapiens 10 3 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41575&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 071 3KB7 24993189 251974447 CHEMBL1094408 ZINC70725351 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 191703 NC(=O)c1nn(CCF)c-2c1CCc1cnc(Nc3ccccc3OC(F)(F)F)nc-21 InChI=1S/C29H32F3N3O5/c1-34(18-19-14-23(38-2)26(40-4)24(15-19)39-3)27(36)20-8-9-25(33-17-20)35-12-10-28(37,11-13-35)21-6-5-7-22(16-21)29(30,31)32/h5-9,14-17,37H,10-13,18H2,1-4H3 CCCWXLXCIAWNTO-UHFFFAOYSA-N 41576 US8614220, A45B2C1Z Serine/threonine-protein kinase PLK1 Homo sapiens 26 3 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41576&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91808124 251974448 ZINC70725354 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 191704 CN1CCN(CC1)c1ccc(C)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C([O-])=O)c1 InChI=1S/C29H35N3O5/c1-31(20-22-16-24(35-2)27(37-4)25(17-22)36-3)28(33)23-10-11-26(30-19-23)32-14-12-29(34,13-15-32)18-21-8-6-5-7-9-21/h5-11,16-17,19,34H,12-15,18,20H2,1-4H3 XURYIMMEUBHCBV-UHFFFAOYSA-N 41577 US8614220, A98B1C3Z Serine/threonine-protein kinase PLK1 Homo sapiens 5 3 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41577&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91808125 251974449 ZINC70725358 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 191705 CN(C)CCCN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C26H29N3O4/c1-28(16-18-13-22(31-2)25(33-4)23(14-18)32-3)26(30)20-9-10-24(27-15-20)29-12-11-19-7-5-6-8-21(19)17-29/h5-10,13-15H,11-12,16-17H2,1-4H3 NHXXGVVBLCIAOV-UHFFFAOYSA-N 41578 US8614220, A101B1C1Z Serine/threonine-protein kinase PLK1 Homo sapiens 46 3 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41578&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91808127 251974450 ZINC70725363 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 191706 COc1ccc(CO)cc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C20H20IN3O4/c1-26-17-8-14(9-18(27-2)19(17)28-3)20(25)23-16-10-22-24(12-16)11-13-5-4-6-15(21)7-13/h4-10,12H,11H2,1-3H3,(H,23,25) MOTBYKZIHMCWAI-UHFFFAOYSA-N 41579 US8614220, A47B1C1Z Serine/threonine-protein kinase PLK1 Homo sapiens 7 3 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91808128 251974451 ZINC70725366 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 198930 CC(C)C[C@@H](NC(=O)CN(CCCCCCc1ccccc1)C(C)=O)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CO)C(=O)N[C@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C35H55N8O11P/c1-22(2)16-27(39-30(46)19-43(24(4)45)15-11-6-5-8-12-25-13-9-7-10-14-25)33(48)40-28(17-26-18-37-21-38-26)34(49)41-29(20-44)35(50)42-31(32(36)47)23(3)54-55(51,52)53/h7,9-10,13-14,18,21-23,27-29,31,44H,5-6,8,11-12,15-17,19-20H2,1-4H3,(H2,36,47)(H,37,38)(H,39,46)(H,40,48)(H,41,49)(H,42,50)(H2,51,52,53)/t23-,27-,28-,29-,31-/m1/s1 HBKQHECDZWHJGF-SVLOURBWSA-N 91675 Peptide-peptoid hybrid, 6q Serine/threonine-protein kinase PLK1 Homo sapiens 15 Curated from the literature by BindingDB 10.1002/cbic.201200206 10.7270/Q2WS8RTH 22570300 aid1799728 Liu, F; Park, JE; Qian, WJ; Lim, D; Scharow, A; Berg, T; Yaffe, MB; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=91675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=91675&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340901 136353217 C06396 ZINC96142356 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 198931 CC(C)C[C@@H](NC(=O)CCCCCCCCc1ccccc1)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CO)C(=O)N[C@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C34H54N7O10P/c1-22(2)17-26(38-29(43)16-12-7-5-4-6-9-13-24-14-10-8-11-15-24)32(45)39-27(18-25-19-36-21-37-25)33(46)40-28(20-42)34(47)41-30(31(35)44)23(3)51-52(48,49)50/h8,10-11,14-15,19,21-23,26-28,30,42H,4-7,9,12-13,16-18,20H2,1-3H3,(H2,35,44)(H,36,37)(H,38,43)(H,39,45)(H,40,46)(H,41,47)(H2,48,49,50)/t23-,26-,27-,28-,30-/m1/s1 KMNQVDQORDUJED-GCXOLXODSA-N 91676 Peptide-peptoid hybrid, 7 Serine/threonine-protein kinase PLK1 Homo sapiens 19 Curated from the literature by BindingDB 10.1002/cbic.201200206 10.7270/Q2WS8RTH 22570300 aid1799728 Liu, F; Park, JE; Qian, WJ; Lim, D; Scharow, A; Berg, T; Yaffe, MB; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=91676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=91676&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340902 136353218 C06396 ZINC96142357 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 198932 CC(C)C[C@@H](NC(=O)CN(CCCCc1ccccc1)C(C)=O)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CO)C(=O)N[C@H]([C@@H](C)CP(O)(O)=O)C(N)=O InChI=1S/C34H53N8O10P/c1-21(2)14-26(38-29(45)17-42(23(4)44)13-9-8-12-24-10-6-5-7-11-24)32(47)39-27(15-25-16-36-20-37-25)33(48)40-28(18-43)34(49)41-30(31(35)46)22(3)19-53(50,51)52/h5-7,10-11,16,20-22,26-28,30,43H,8-9,12-15,17-19H2,1-4H3,(H2,35,46)(H,36,37)(H,38,45)(H,39,47)(H,40,48)(H,41,49)(H2,50,51,52)/t22-,26+,27+,28+,30+/m0/s1 UGJSSKAFWMVLDA-ZLDYYJMESA-N 91677 Peptide-peptoid hybrid, 13 Serine/threonine-protein kinase PLK1 Homo sapiens 71 Curated from the literature by BindingDB 10.1002/cbic.201200206 10.7270/Q2WS8RTH 22570300 aid1799728 Liu, F; Park, JE; Qian, WJ; Lim, D; Scharow, A; Berg, T; Yaffe, MB; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=91677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=91677&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57340903 136353219 C06396 ZINC96142358 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 200825 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase PLK1 Homo sapiens >10000 Curated from the literature by BindingDB 10.1074/jbc.M109.005694 10.7270/Q2WH2NK3 19359241 aid1799800 Scutt, PJ; Chu, ML; Sloane, DA; Cherry, M; Bignell, CR; Williams, DH; Eyers, PA University of Manchester http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 200914 Oc1ccc2oc3c(CCCNC3=O)c2c1 InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-12(15)11(8)16-10/h3-4,6,14H,1-2,5H2,(H,13,15) AACFPJSJOWQNBN-UHFFFAOYSA-N 32334 7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofur[2,3-c]azepin-1-one::7-hydroxy-2,3,4,5-tetrahydrobenzofuro[2,3-c]azepin-1-one::7-oxidanyl-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one::MLS000043346::SMR000019965::cid_755673 Serine/threonine-protein kinase PLK1 Homo sapiens 2.03e+4 Curated from the literature by BindingDB 10.1074/jbc.M805358200 10.7270/Q20863WJ 18829454 aid1799807 Sharlow, ER; Giridhar, KV; LaValle, CR; Chen, J; Leimgruber, S; Barrett, R; Bravo-Altamirano, K; Wipf, P; Lazo, JS; Wang, QJ University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32334&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 755673 252615771 ZINC00210586 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 200918 Oc1ccc2oc(=O)c3NCCCc3c2c1 InChI=1S/C12H11NO3/c14-7-3-4-10-9(6-7)8-2-1-5-13-11(8)12(15)16-10/h3-4,6,13-14H,1-2,5H2 VDZXTSOINJESSP-UHFFFAOYSA-N 92601 CID 797718 Serine/threonine-protein kinase PLK1 Homo sapiens 2.19e+4 Curated from the literature by BindingDB 10.1074/jbc.M805358200 10.7270/Q20863WJ 18829454 aid1799807 Sharlow, ER; Giridhar, KV; LaValle, CR; Chen, J; Leimgruber, S; Barrett, R; Bravo-Altamirano, K; Wipf, P; Lazo, JS; Wang, QJ University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92601&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 797718 160845098 ZINC00302630 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 228395 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 8 7.9 US Patent 10.7270/Q2SJ1J7D aid1800216 US8598172 Caruso, M; Beria, I; Brasca, MG; Posteri, H; Fachin, G Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 228396 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(ccc3OC(F)(F)F)N3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C26H34F3N7O2/c1-4-22-25(37)34(3)23-17-30-26(32-24(23)36(22)19-7-5-6-8-19)31-21-15-20(35-13-11-33(2)12-14-35)10-9-18(21)16-29-38(27)28/h9-10,15,17,19,22H,4-8,11-14H2,1-3H3,(H,30,31,32)/t22-/m1/s1 JXUDJQNQCCKTKS-JOCHJYFZSA-N 108214 US8598172, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 32 7.9 US Patent 10.7270/Q2SJ1J7D aid1800216 US8598172 Caruso, M; Beria, I; Brasca, MG; Posteri, H; Fachin, G Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=108214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=108214&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42611166 186525084 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273359 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCNCC4)nc3-c12 InChI=1S/C22H23F3N8O2/c1-32-19-14(18(31-32)20(26)34)4-2-12-11-28-21(30-17(12)19)29-15-10-13(33-8-6-27-7-9-33)3-5-16(15)35-22(23,24)25/h3,5,10-11,27H,2,4,6-9H2,1H3,(H2,26,34)(H,28,29,30) TUWAYASUNDRSML-UHFFFAOYSA-N 50329915 1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271644 Serine/threonine-protein kinase PLK1 Homo sapiens 2 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50899254 123109030 CHEMBL1271644 ZINC43196884 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273360 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31) QHLVBNKYJGBCQJ-UHFFFAOYSA-N 50343559 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE::1-(2-hydroxyethyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1738758 Serine/threonine-protein kinase PLK1 Homo sapiens 3 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343559&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 937 2YAC 49792852 131346495 CHEMBL1738758 ZINC43196885 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273361 Cc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H18N6O/c1-10-5-3-4-6-13(10)21-18-20-9-11-7-8-12-15(17(19)25)23-24(2)16(12)14(11)22-18/h3-6,9H,7-8H2,1-2H3,(H2,19,25)(H,20,21,22) OXPLZKSKLWBEIM-UHFFFAOYSA-N 50318085 1-Methyl-8-[(2-methylphenyl)amino]-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094477 Serine/threonine-protein kinase PLK1 Homo sapiens 14 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24992861 104152446 CHEMBL1094477 ZINC49072889 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273362 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCF)c4-c3n2)C(N)=O)c1 InChI=1S/C24H26F4N8O2/c1-34-8-10-35(11-9-34)15-3-5-18(38-24(26,27)28)17(12-15)31-23-30-13-14-2-4-16-20(22(29)37)33-36(7-6-25)21(16)19(14)32-23/h3,5,12-13H,2,4,6-11H2,1H3,(H2,29,37)(H,30,31,32) VPWDLLHGBJTELF-UHFFFAOYSA-N 50329913 1-(2-fluoroethyl)-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271751 Serine/threonine-protein kinase PLK1 Homo sapiens 5 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329913&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56675140 123109028 CHEMBL1271751 ZINC43196886 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273363 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C=C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H25F3N8O2/c1-3-35-21-16(20(32-35)22(28)36)6-4-14-13-29-23(31-19(14)21)30-17-12-15(34-10-8-33(2)9-11-34)5-7-18(17)37-24(25,26)27/h3,5,7,12-13H,1,4,6,8-11H2,2H3,(H2,28,36)(H,29,30,31) IWNBRVJHAXKTLL-UHFFFAOYSA-N 50329929 8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-vinyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271870 Serine/threonine-protein kinase PLK1 Homo sapiens 1 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329929&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56657856 123109044 CHEMBL1271870 ZINC43196883 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273364 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C23H25F3N8O2/c1-32-7-9-34(10-8-32)14-4-6-17(36-23(24,25)26)16(11-14)29-22-28-12-13-3-5-15-19(21(27)35)31-33(2)20(15)18(13)30-22/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,27,35)(H,28,29,30) VEFDUZNTHFBSFU-UHFFFAOYSA-N 50329914 1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272140 Serine/threonine-protein kinase PLK1 Homo sapiens 1 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24825755 123109029 CHEMBL1272140 ZINC43196882 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273365 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C([O-])=O)c1 InChI=1S/C23H24F3N7O3/c1-31-7-9-33(10-8-31)14-4-6-17(36-23(24,25)26)16(11-14)28-22-27-12-13-3-5-15-19(21(34)35)30-32(2)20(15)18(13)29-22/h4,6,11-12H,3,5,7-10H2,1-2H3,(H,34,35)(H,27,28,29)/p-1 QROBXWMBDYEVNI-UHFFFAOYSA-M 139106 US8614220, A51B1C3Z Serine/threonine-protein kinase PLK1 Homo sapiens 10 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139106&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91669036 249870428 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273366 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCCl)c4-c3n2)C(N)=O)c1 InChI=1S/C24H26ClF3N8O2/c1-34-8-10-35(11-9-34)15-3-5-18(38-24(26,27)28)17(12-15)31-23-30-13-14-2-4-16-20(22(29)37)33-36(7-6-25)21(16)19(14)32-23/h3,5,12-13H,2,4,6-11H2,1H3,(H2,29,37)(H,30,31,32) OCPMRHZHACWECI-UHFFFAOYSA-N 50329916 1-(2-chloroethyl)-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271869 Serine/threonine-protein kinase PLK1 Homo sapiens 13 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329916&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56681780 123109031 CHEMBL1271869 ZINC70690070 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273367 CNC(=O)c1nn(C)c-2c1CCc1cnc(Nc3cc(ccc3OC)N3CCN(C)CC3)nc-21 InChI=1S/C24H30N8O2/c1-25-23(33)21-17-7-5-15-14-26-24(28-20(15)22(17)31(3)29-21)27-18-13-16(6-8-19(18)34-4)32-11-9-30(2)10-12-32/h6,8,13-14H,5,7,9-12H2,1-4H3,(H,25,33)(H,26,27,28) RBYMMVRBIIJFHH-UHFFFAOYSA-N 139107 US8614220, A85B1C4Z Serine/threonine-protein kinase PLK1 Homo sapiens 26 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139107&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24993514 249870429 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273368 CN1CCC(=CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H24F3N7O2/c1-33-9-7-13(8-10-33)14-4-6-18(36-24(25,26)27)17(11-14)30-23-29-12-15-3-5-16-20(22(28)35)32-34(2)21(16)19(15)31-23/h4,6-7,11-12H,3,5,8-10H2,1-2H3,(H2,28,35)(H,29,30,31) DFKJNGVBNCASDM-UHFFFAOYSA-N 50343568 1-methyl-8-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774327 Serine/threonine-protein kinase PLK1 Homo sapiens 8 7.9 US Patent 10.7270/Q23J3BNV aid1800756 US8614220 Caruso, M; Beria, I; Brasca, MG; Ferguson, R; Posteri, H; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343568&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54585267 131346504 CHEMBL1774327 ZINC71296607 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273840 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(Sc2ccc(F)cc2)c1=O InChI=1S/C22H16FN5OS/c1-28-20-14(11-19(21(28)29)30-17-5-2-15(23)3-6-17)12-25-22(27-20)26-16-4-7-18-13(10-16)8-9-24-18/h2-12,24H,1H3,(H,25,26,27) FJECSOOLAWUZAB-UHFFFAOYSA-N 139539 US8889696, 39 Serine/threonine-protein kinase PLK1 Homo sapiens 7818 US Patent 10.7270/Q2930RVR aid1800772 US8889696 Reddy, EP; Reddy, MV Temple University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139539&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 70895719 249871007 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 273873 CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 YISMQBFJYDFMAL-AESIHLKFSA-N 139540 US10189849, staurosporine::US10307427, Staurosporine::US10329300, Staurosporine::US11091485, Compound Staurosporine::US11542261, Compound staurosporine::US8889696, Staurosporine::US9051313, Staurosporine::US9586965, Control Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 3673 US Patent 10.7270/Q2930RVR aid1800772 US8889696 Reddy, EP; Reddy, MV Temple University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139540&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91669270 249871008 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 327851 COc1cc(ccc1Nc1ncc2N(C)C(=O)C3(CC3)CN(C3CCCC3)c2n1)C(=O)NN1CCN(C)CC1 InChI=1S/C28H38N8O3/c1-33-12-14-35(15-13-33)32-25(37)19-8-9-21(23(16-19)39-3)30-27-29-17-22-24(31-27)36(20-6-4-5-7-20)18-28(10-11-28)26(38)34(22)2/h8-9,16-17,20H,4-7,10-15,18H2,1-3H3,(H,32,37)(H,29,30,31) DAXUUNAELZSVRJ-UHFFFAOYSA-N 181015 US9133199, 254 Serine/threonine-protein kinase PLK1 Homo sapiens <10 7.5 US Patent 10.7270/Q21C1VNZ aid1801638 US9133199 Hollick, JJ; Jones, SD; Flynn, CJ; Thomas, MG Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181015&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42638395 313363130 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 327852 COc1cc(ccc1Nc1ncc2N(C)C(=O)C3(CC3)CN(C3CCCC3)c2n1)C(=O)NN1CCCC1 InChI=1S/C27H35N7O3/c1-32-21-16-28-26(30-23(21)34(19-7-3-4-8-19)17-27(11-12-27)25(32)36)29-20-10-9-18(15-22(20)37-2)24(35)31-33-13-5-6-14-33/h9-10,15-16,19H,3-8,11-14,17H2,1-2H3,(H,31,35)(H,28,29,30) ZUESHYKNMGFCAY-UHFFFAOYSA-N 181016 US9133199, I-253 Serine/threonine-protein kinase PLK1 Homo sapiens <10 7.5 US Patent 10.7270/Q21C1VNZ aid1801638 US9133199 Hollick, JJ; Jones, SD; Flynn, CJ; Thomas, MG Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=181016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=181016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57940524 313363131 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340524 CNC(=O)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1 InChI=1S/C16H14N2O3S/c1-17-16(19)14-11-18(15-10-6-5-9-13(14)15)22(20,21)12-7-3-2-4-8-12/h2-11H,1H3,(H,17,19) ZSTLNSLXYNDRIC-UHFFFAOYSA-N 190244 US9175357, 5591 Serine/threonine-protein kinase PLK1 Homo sapiens 375000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190244&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 14943552 316921830 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340525 CNC(=O)c1cc(n[nH]1)-c1cccc(OC)c1 InChI=1S/C12H13N3O2/c1-13-12(16)11-7-10(14-15-11)8-4-3-5-9(6-8)17-2/h3-7H,1-2H3,(H,13,16)(H,14,15) NOCILZGUNANHPL-UHFFFAOYSA-N 190245 US9175357, 5593 Serine/threonine-protein kinase PLK1 Homo sapiens 380000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190245&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 73609918 316921831 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340526 CNC(=O)CN1C(=O)COc2ccc(C)cc12 InChI=1S/C12H14N2O3/c1-8-3-4-10-9(5-8)14(6-11(15)13-2)12(16)7-17-10/h3-5H,6-7H2,1-2H3,(H,13,15) XGPUHLZHIZACTI-UHFFFAOYSA-N 190246 US9175357, 5594 Serine/threonine-protein kinase PLK1 Homo sapiens 350000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190246&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53016051 316921832 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340527 CNC(=O)CSc1ncnc2sc(C)cc12 InChI=1S/C10H11N3OS2/c1-6-3-7-9(15-4-8(14)11-2)12-5-13-10(7)16-6/h3,5H,4H2,1-2H3,(H,11,14) YPPJTGUTQJUGDK-UHFFFAOYSA-N 190247 US9175357, 5595 Serine/threonine-protein kinase PLK1 Homo sapiens 475000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190247&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 68178481 316921833 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340528 CNC(=O)c1cc(c(s1)C(F)(F)F)-c1ccccc1 InChI=1S/C13H10F3NOS/c1-17-12(18)10-7-9(8-5-3-2-4-6-8)11(19-10)13(14,15)16/h2-7H,1H3,(H,17,18) OFSWPYTZVJFWNS-UHFFFAOYSA-N 190248 US9175357, 5597 Serine/threonine-protein kinase PLK1 Homo sapiens 500000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190248&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 121494135 316921834 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340529 CNC(=O)c1ccc(cc1)-c1noc(C)n1 InChI=1S/C11H11N3O2/c1-7-13-10(14-16-7)8-3-5-9(6-4-8)11(15)12-2/h3-6H,1-2H3,(H,12,15) WDSIXINVFYGLCI-UHFFFAOYSA-N 190249 US9175357, 5598 Serine/threonine-protein kinase PLK1 Homo sapiens 320000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190249&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53015124 316921835 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340530 CNC(=O)c1cc(-c2ccccc2)n(c1C)-c1ccccc1 InChI=1S/C19H18N2O/c1-14-17(19(22)20-2)13-18(15-9-5-3-6-10-15)21(14)16-11-7-4-8-12-16/h3-13H,1-2H3,(H,20,22) KSOTYGSPFVAQRD-UHFFFAOYSA-N 190250 US9175357, 5599 Serine/threonine-protein kinase PLK1 Homo sapiens 600000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190250&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 68178482 316921836 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340531 CNC(=O)C1=CC(CCCN2CCOCC2)[N](=C1C)c1ccccc1 InChI=1S/C20H28N3O2/c1-16-19(20(24)21-2)15-18(23(16)17-7-4-3-5-8-17)9-6-10-22-11-13-25-14-12-22/h3-5,7-8,15,18H,6,9-14H2,1-2H3,(H,21,24) JSTJELALMCFELW-UHFFFAOYSA-N 190251 US9175357, 5600 Serine/threonine-protein kinase PLK1 Homo sapiens 550000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190251&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 121493729 316921837 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340532 CNC(=O)c1ccc2ncccc2c1 InChI=1S/C11H10N2O/c1-12-11(14)9-4-5-10-8(7-9)3-2-6-13-10/h2-7H,1H3,(H,12,14) MIALGPVTPXMCIB-UHFFFAOYSA-N 190252 US9175357, 5601 Serine/threonine-protein kinase PLK1 Homo sapiens 400000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190252&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 59810763 316921838 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340533 CNC(=O)Cn1cc(ncc1=O)-c1ccc(C)cc1 InChI=1S/C14H15N3O2/c1-10-3-5-11(6-4-10)12-8-17(9-13(18)15-2)14(19)7-16-12/h3-8H,9H2,1-2H3,(H,15,18) VRJNMHDVYAGUMB-UHFFFAOYSA-N 190253 US9175357, 5603 Serine/threonine-protein kinase PLK1 Homo sapiens 250000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190253&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 68178483 316921839 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340534 CNC(=O)c1cc(OC)c2OCCOc2c1 InChI=1S/C11H13NO4/c1-12-11(13)7-5-8(14-2)10-9(6-7)15-3-4-16-10/h5-6H,3-4H2,1-2H3,(H,12,13) IISISGUKNCNWHZ-UHFFFAOYSA-N 190254 US9175357, 5604 Serine/threonine-protein kinase PLK1 Homo sapiens 300000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190254&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 39969430 316921840 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340535 CNC(=O)c1sc(c(c1N)-c1ccccc1)C(F)(F)F InChI=1S/C13H11F3N2OS/c1-18-12(19)10-9(17)8(7-5-3-2-4-6-7)11(20-10)13(14,15)16/h2-6H,17H2,1H3,(H,18,19) YEKJLFRHXHILGB-UHFFFAOYSA-N 190255 US9175357, 5607 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190255&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 121494136 316921841 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340536 CNC(=O)c1cccc2ccccc12 InChI=1S/C12H11NO/c1-13-12(14)11-8-4-6-9-5-2-3-7-10(9)11/h2-8H,1H3,(H,13,14) SDDKAODVKCSVMH-UHFFFAOYSA-N 190256 US9175357, 5753 Serine/threonine-protein kinase PLK1 Homo sapiens 104000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190256&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 18839 316921842 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340537 CNC(=O)c1ccc(OC)cc1 InChI=1S/C9H11NO2/c1-10-9(11)7-3-5-8(12-2)6-4-7/h3-6H,1-2H3,(H,10,11) SIOAPROKUUGJAQ-UHFFFAOYSA-N 190257 US9175357, 5754 Serine/threonine-protein kinase PLK1 Homo sapiens 125000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190257&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search VZH 7FNX 346031 316921843 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340538 CNC(=O)c1ccc(OC)c2ccccc12 InChI=1S/C13H13NO2/c1-14-13(15)11-7-8-12(16-2)10-6-4-3-5-9(10)11/h3-8H,1-2H3,(H,14,15) CPIZGAGIZIZVDV-UHFFFAOYSA-N 190258 US9175357, 5756 Serine/threonine-protein kinase PLK1 Homo sapiens 99000 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190258&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 13433112 316921844 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340539 CCCOc1ccc(cc1)C(=O)NC InChI=1S/C11H15NO2/c1-3-8-14-10-6-4-9(5-7-10)11(13)12-2/h4-7H,3,8H2,1-2H3,(H,12,13) FYYPZXSDIANGLR-UHFFFAOYSA-N 190259 US9175357, 5785 Serine/threonine-protein kinase PLK1 Homo sapiens 29500 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190259&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4938535 316921845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340540 CCOc1ccc(cc1)C(=O)NC InChI=1S/C10H13NO2/c1-3-13-9-6-4-8(5-7-9)10(12)11-2/h4-7H,3H2,1-2H3,(H,11,12) VCAGHRZKRUVEMN-UHFFFAOYSA-N 190260 US9175357, 5786 Serine/threonine-protein kinase PLK1 Homo sapiens 64700 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190260&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 789021 316921846 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340541 CCc1ccc(cc1)C(=O)NC InChI=1S/C10H13NO/c1-3-8-4-6-9(7-5-8)10(12)11-2/h4-7H,3H2,1-2H3,(H,11,12) QDDXVDKSCWSDHK-UHFFFAOYSA-N 190261 US9175357, 5788 Serine/threonine-protein kinase PLK1 Homo sapiens 16500 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190261&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 20191385 316921847 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340542 CNC(=O)c1ccc(SC)cc1 InChI=1S/C9H11NOS/c1-10-9(11)7-3-5-8(12-2)6-4-7/h3-6H,1-2H3,(H,10,11) UTWKXHLTRDUFAC-UHFFFAOYSA-N 190262 US9175357, 5791 Serine/threonine-protein kinase PLK1 Homo sapiens 18500 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190262&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4518228 316921848 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340543 CNC(=O)c1ccc(NC)cc1 InChI=1S/C9H12N2O/c1-10-8-5-3-7(4-6-8)9(12)11-2/h3-6,10H,1-2H3,(H,11,12) CPMVJEOEMKNAOM-UHFFFAOYSA-N 190263 US9175357, 5792 Serine/threonine-protein kinase PLK1 Homo sapiens 31200 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190263&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 18958152 316921849 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340544 CCCc1ccc(cc1)C(=O)NC InChI=1S/C11H15NO/c1-3-4-9-5-7-10(8-6-9)11(13)12-2/h5-8H,3-4H2,1-2H3,(H,12,13) KTQXJXGIKSHDSE-UHFFFAOYSA-N 190264 US9175357, 5826 Serine/threonine-protein kinase PLK1 Homo sapiens 10800 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190264&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 20253152 316921850 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340545 CCCCc1ccc(cc1)C(=O)NC InChI=1S/C12H17NO/c1-3-4-5-10-6-8-11(9-7-10)12(14)13-2/h6-9H,3-5H2,1-2H3,(H,13,14) QTBWAQMGHQABHU-UHFFFAOYSA-N 190265 US9175357, 5827 Serine/threonine-protein kinase PLK1 Homo sapiens 8600 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190265&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 20253177 316921851 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 340546 CCCNc1ccc(cc1)C(=O)NC InChI=1S/C11H16N2O/c1-3-8-13-10-6-4-9(5-7-10)11(14)12-2/h4-7,13H,3,8H2,1-2H3,(H,12,14) GLLDWDBLWRUOGZ-UHFFFAOYSA-N 190266 US9175357, 5830 Serine/threonine-protein kinase PLK1 Homo sapiens 16500 8 25.00 C US Patent 10.7270/Q2V40T14 aid1801831 US9175357 McInnes, C; Farag, DB University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=190266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=190266&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 43683703 316921852 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370211 CN1c2cnc(Nc3ccc(cn3)N3CCC(O)CC3)nc2N(CCC1=O)C1CCCC1 InChI=1S/C23H31N7O2/c1-28-19-15-25-23(27-22(19)30(13-10-21(28)32)16-4-2-3-5-16)26-20-7-6-17(14-24-20)29-11-8-18(31)9-12-29/h6-7,14-16,18,31H,2-5,8-13H2,1H3,(H,24,25,26,27) WUDDKNUPJTYVAB-UHFFFAOYSA-N 209393 US9266890, I-1 Serine/threonine-protein kinase PLK1 Homo sapiens 49 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209393&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46844026 328082482 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370212 COc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C27H37N7O3/c1-32-13-10-19(11-14-32)29-26(36)18-8-9-21(23(16-18)37-3)30-27-28-17-22-25(31-27)34(20-6-4-5-7-20)15-12-24(35)33(22)2/h8-9,16-17,19-20H,4-7,10-15H2,1-3H3,(H,29,36)(H,28,30,31) JFRNFMQDZRWAQB-UHFFFAOYSA-N 50435736 CHEMBL2392552::US9266890, I-3 Serine/threonine-protein kinase PLK1 Homo sapiens 0.57 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435736&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16722190 175448053 CHEMBL2392552 ZINC43172166 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370213 COc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N1CCC(O)CC1 InChI=1S/C25H34N6O3/c1-29-21-16-26-25(28-24(21)31(14-11-23(29)33)17-5-3-4-6-17)27-20-8-7-18(15-22(20)34-2)30-12-9-19(32)10-13-30/h7-8,15-17,19,32H,3-6,9-14H2,1-2H3,(H,26,27,28) KBILTEUAXWLXKP-UHFFFAOYSA-N 209397 US9266890, I-6 Serine/threonine-protein kinase PLK1 Homo sapiens 19 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209397&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 92M 3H9F 25271586 328082483 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370214 COc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N(C)CCO InChI=1S/C23H32N6O3/c1-27(12-13-30)17-8-9-18(20(14-17)32-3)25-23-24-15-19-22(26-23)29(16-6-4-5-7-16)11-10-21(31)28(19)2/h8-9,14-16,30H,4-7,10-13H2,1-3H3,(H,24,25,26) RSYDNACOROMVHV-UHFFFAOYSA-N 209398 US9266890, I-7 Serine/threonine-protein kinase PLK1 Homo sapiens 36 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209398&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46844027 328082484 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370215 COc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N(C)CCCO InChI=1S/C24H34N6O3/c1-28(12-6-14-31)18-9-10-19(21(15-18)33-3)26-24-25-16-20-23(27-24)30(17-7-4-5-8-17)13-11-22(32)29(20)2/h9-10,15-17,31H,4-8,11-14H2,1-3H3,(H,25,26,27) PPPDATIUXAGJGR-UHFFFAOYSA-N 209399 US9266890, I-8 Serine/threonine-protein kinase PLK1 Homo sapiens 35 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209399&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46844084 328082485 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370216 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N1CCC(O)CC1 InChI=1S/C26H36N6O3/c1-3-35-23-16-19(31-13-10-20(33)11-14-31)8-9-21(23)28-26-27-17-22-25(29-26)32(18-6-4-5-7-18)15-12-24(34)30(22)2/h8-9,16-18,20,33H,3-7,10-15H2,1-2H3,(H,27,28,29) WELBJLUKWAJOQV-UHFFFAOYSA-N 36486 9-Cyclopentyl-2-(2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenylamino)-5-methyl-8,9-dihydro-5H-pyrimido[5,4-b][1,4]diazepin-6(7H)-one::Mps1-IN-2::Scaffold, B13::US9266890, I-10 Serine/threonine-protein kinase PLK1 Homo sapiens 47 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36486&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44968267 117644072 ZINC62260347 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370217 CC(C)Oc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N1CCC(O)CC1 InChI=1S/C27H38N6O3/c1-18(2)36-24-16-20(32-13-10-21(34)11-14-32)8-9-22(24)29-27-28-17-23-26(30-27)33(19-6-4-5-7-19)15-12-25(35)31(23)3/h8-9,16-19,21,34H,4-7,10-15H2,1-3H3,(H,28,29,30) LTQRUCOWRVPXHK-UHFFFAOYSA-N 209401 US9266890, I-11 Serine/threonine-protein kinase PLK1 Homo sapiens 200 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209401&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46844086 328082487 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370218 COc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N1CCN(CCO)CC1 InChI=1S/C26H37N7O3/c1-30-22-18-27-26(29-25(22)33(10-9-24(30)35)19-5-3-4-6-19)28-21-8-7-20(17-23(21)36-2)32-13-11-31(12-14-32)15-16-34/h7-8,17-19,34H,3-6,9-16H2,1-2H3,(H,27,28,29) POBSLBATAWVCHO-UHFFFAOYSA-N 209402 US9266890, I-12 Serine/threonine-protein kinase PLK1 Homo sapiens 8 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209402&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46844087 328082488 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 370219 CN1c2cnc(Nc3ccc(cc3)C(N)=O)nc2N(C2CCCC2)[C@@H]2CCC[C@@H]2C1=O InChI=1S/C23H28N6O2/c1-28-19-13-25-23(26-15-11-9-14(10-12-15)20(24)30)27-21(19)29(16-5-2-3-6-16)18-8-4-7-17(18)22(28)31/h9-13,16-18H,2-8H2,1H3,(H2,24,30)(H,25,26,27)/t17-,18+/m0/s1 VJDBYVPTQWPRPA-ZWKOTPCHSA-N 209414 US9266890, I-24 Serine/threonine-protein kinase PLK1 Homo sapiens 18 US Patent 10.7270/Q27M06RB aid1802308 US9266890 Gray, NS; Deng, X; Kwiatkowski, NP Dana-Farber Cancer Institute Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209414&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B7B 6EIP 68034378 328082493 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452966 NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+ BRZWHXQQGAAXPX-VZUCSPMQSA-N 259810 US9505766, 10 Serine/threonine-protein kinase PLK1 Homo sapiens 30000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259810&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52938775 350084504 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452967 NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+ AENKGHPUTMOKKU-MDWZMJQESA-N 259811 US9505766, 11 Serine/threonine-protein kinase PLK1 Homo sapiens 1000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259811&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 67206349 350084505 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452968 NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+ FYPQUUUPVSAJTG-NTEUORMPSA-N 259821 US9505766, 22 Serine/threonine-protein kinase PLK1 Homo sapiens 100000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259821&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 68347790 350084515 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452969 NC(=O)C(=C\c1ccc(cc1)-c1cn[nH]c1)\C#N InChI=1S/C13H10N4O/c14-6-11(13(15)18)5-9-1-3-10(4-2-9)12-7-16-17-8-12/h1-5,7-8H,(H2,15,18)(H,16,17)/b11-5+ BNRLLVUNYCBXNJ-VZUCSPMQSA-N 259823 US9505766, 24 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259823&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52938890 350084517 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452970 N#C\C=C\c1ccc(cc1)-c1ccncc1 InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+ PCFKTRCTTGIQLS-OWOJBTEDSA-N 259826 US9505766, 30 Serine/threonine-protein kinase PLK1 Homo sapiens >300000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 89403409 350084520 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452971 CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+ FJKJKXLQLWSSGR-QGOAFFKASA-N 259827 US9505766, 31 Serine/threonine-protein kinase PLK1 Homo sapiens 300000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259827&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52938894 350084521 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452972 NC(=O)C(=C\c1nc2c(N)ncnc2n1CCCO)\C#N InChI=1S/C12H13N7O2/c13-5-7(11(15)21)4-8-18-9-10(14)16-6-17-12(9)19(8)2-1-3-20/h4,6,20H,1-3H2,(H2,15,21)(H2,14,16,17)/b7-4+ YADAJQRYASQJMB-QPJJXVBHSA-N 259829 US9505766, 33 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259829&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52938896 350084523 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452973 COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(N)=O)cc12 InChI=1S/C20H18N4O4/c1-26-16-8-12(9-17(27-2)19(16)28-3)18-14-7-11(4-5-15(14)23-24-18)6-13(10-21)20(22)25/h4-9H,1-3H3,(H2,22,25)(H,23,24)/b13-6+ IBUMAHMUIWPTCV-AWNIVKPZSA-N 259836 US9505766, 40 Serine/threonine-protein kinase PLK1 Homo sapiens 650 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259836&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 131954194 350084530 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452974 CNC(=O)C(=C\c1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1)\C#N InChI=1S/C21H20N4O4/c1-23-21(26)14(11-22)7-12-5-6-16-15(8-12)19(25-24-16)13-9-17(27-2)20(29-4)18(10-13)28-3/h5-10H,1-4H3,(H,23,26)(H,24,25)/b14-7+ JGIBKTCCYJBOMS-VGOFMYFVSA-N 259837 US9505766, 41 Serine/threonine-protein kinase PLK1 Homo sapiens 650 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 131954195 350084531 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 452975 COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)N(C)C)cc12 InChI=1S/C22H22N4O4/c1-26(2)22(27)15(12-23)8-13-6-7-17-16(9-13)20(25-24-17)14-10-18(28-3)21(30-5)19(11-14)29-4/h6-11H,1-5H3,(H,24,25)/b15-8+ VLDMPVNRZYIDHU-OVCLIPMQSA-N 259838 US9505766, 42 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803663 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 131954196 350084532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50073711 CN1CCC(CC1)Oc1ccc2ncn(-c3cc(OCc4ccccc4C(F)(F)F)c(s3)C(N)=O)c2c1 InChI=1S/C26H25F3N4O3S/c1-32-10-8-17(9-11-32)36-18-6-7-20-21(12-18)33(15-31-20)23-13-22(24(37-23)25(30)34)35-14-16-4-2-3-5-19(16)26(27,28)29/h2-7,12-13,15,17H,8-11,14H2,1H3,(H2,30,34) FNHUNERGHGEZMB-UHFFFAOYSA-N 50339795 5-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-benzimidazol-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide::CHEMBL1614933 Serine/threonine-protein kinase PLK1 Homo sapiens <9 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339795&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search ED8 2XNO 50990893 125089897 CHEMBL1614933 ZINC64746655 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50073716 CC(Oc1cc(sc1C(N)=O)-n1cnc2ccccc12)c1ccccc1C(F)(F)F InChI=1S/C21H16F3N3O2S/c1-12(13-6-2-3-7-14(13)21(22,23)24)29-17-10-18(30-19(17)20(25)28)27-11-26-15-8-4-5-9-16(15)27/h2-12H,1H3,(H2,25,28) SQYKBXHMNBHADB-UHFFFAOYSA-N 50339798 (+/-)-5-(1H-Benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1689163 Serine/threonine-protein kinase PLK1 Homo sapiens <9 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339798&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 430 2XNN 51355436 125089900 CHEMBL1689163 ZINC66113200 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50073719 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H27F3N4O3S/c1-16(19-5-3-4-6-20(19)27(28,29)30)36-23-14-24(38-25(23)26(31)35)34-15-32-21-8-7-18(13-22(21)34)37-17-9-11-33(2)12-10-17/h3-8,13-17H,9-12H2,1-2H3,(H2,31,35)/t16-/m1/s1 SWIVJTVGOIXUKC-MRXNPFEDSA-N 28216 5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-1,3-benzodiazol-1-yl}-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide::benzimidazole thiophene carboxamide, 24 Serine/threonine-protein kinase PLK1 Homo sapiens <9 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28216&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search WGZ 2XNM 16050925 58097405 ZINC59716256 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50075835 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 129000 ChEMBL 10.1016/j.bmc.2012.11.054 10.7270/Q2QZ2C94 23276450 Mita, Y; Noguchi-Yachide, T; Ishikawa, M; Hashimoto, Y The University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50075836 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 22400 ChEMBL 10.1016/j.bmc.2012.11.054 10.7270/Q2QZ2C94 23276450 Mita, Y; Noguchi-Yachide, T; Ishikawa, M; Hashimoto, Y The University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50075837 Cc1cc(-c2ccc(cc2)C#N)c(OCCO)c(c1)-c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C23H19N5O2/c1-15-12-20(17-4-2-16(14-24)3-5-17)22(30-11-10-29)21(13-15)18-6-8-19(9-7-18)23-25-27-28-26-23/h2-9,12-13,29H,10-11H2,1H3,(H,25,26,27,28) FXFITXFZTUYDTA-UHFFFAOYSA-N 50426930 CHEMBL2324036 Serine/threonine-protein kinase PLK1 Homo sapiens 139000 ChEMBL 10.1016/j.bmc.2012.11.054 10.7270/Q2QZ2C94 23276450 Mita, Y; Noguchi-Yachide, T; Ishikawa, M; Hashimoto, Y The University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71524012 164155805 CHEMBL2324036 ZINC95581534 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50075838 Cc1cc(-c2ccc(cc2)C#N)c(OCCO)c(c1)-c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C23H19N5O2/c1-15-12-20(17-4-2-16(14-24)3-5-17)22(30-11-10-29)21(13-15)18-6-8-19(9-7-18)23-25-27-28-26-23/h2-9,12-13,29H,10-11H2,1H3,(H,25,26,27,28) FXFITXFZTUYDTA-UHFFFAOYSA-N 50426930 CHEMBL2324036 Serine/threonine-protein kinase PLK1 Homo sapiens 146000 ChEMBL 10.1016/j.bmc.2012.11.054 10.7270/Q2QZ2C94 23276450 Mita, Y; Noguchi-Yachide, T; Ishikawa, M; Hashimoto, Y The University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71524012 164155805 CHEMBL2324036 ZINC95581534 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098726 [O-][N+](=O)c1ccccc1\C=C\C(=O)NNC(=O)c1ccc2OCCOc2c1 InChI=1S/C18H15N3O6/c22-17(8-6-12-3-1-2-4-14(12)21(24)25)19-20-18(23)13-5-7-15-16(11-13)27-10-9-26-15/h1-8,11H,9-10H2,(H,19,22)(H,20,23)/b8-6+ YGPQMFXMKKHCNZ-SOFGYWHQSA-N 50016495 CHEMBL3260236 Serine/threonine-protein kinase PLK1 Homo sapiens 190 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016495&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643718 103927893 CHEMBL3260236 ZINC04040206 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098746 COc1cccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)c1 InChI=1S/C19H18N2O5/c1-24-15-4-2-3-13(11-15)5-8-18(22)20-21-19(23)14-6-7-16-17(12-14)26-10-9-25-16/h2-8,11-12H,9-10H2,1H3,(H,20,22)(H,21,23)/b8-5+ UWCNNPLPNWIHHP-VMPITWQZSA-N 50016496 CHEMBL3260241 Serine/threonine-protein kinase PLK1 Homo sapiens 30 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016496&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643719 103927894 CHEMBL3260241 ZINC03783083 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098747 [O-][N+](=O)c1cccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)c1 InChI=1S/C18H15N3O6/c22-17(7-4-12-2-1-3-14(10-12)21(24)25)19-20-18(23)13-5-6-15-16(11-13)27-9-8-26-15/h1-7,10-11H,8-9H2,(H,19,22)(H,20,23)/b7-4+ DGVGLURAKIWTCE-QPJJXVBHSA-N 50016497 CHEMBL3260242 Serine/threonine-protein kinase PLK1 Homo sapiens 1550 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016497&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643720 103927895 CHEMBL3260242 ZINC29466990 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098748 Fc1ccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)cc1 InChI=1S/C18H15FN2O4/c19-14-5-1-12(2-6-14)3-8-17(22)20-21-18(23)13-4-7-15-16(11-13)25-10-9-24-15/h1-8,11H,9-10H2,(H,20,22)(H,21,23)/b8-3+ AAMGHFYBPZUVNQ-FPYGCLRLSA-N 50016498 CHEMBL3260243 Serine/threonine-protein kinase PLK1 Homo sapiens 590 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016498&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643721 103927896 CHEMBL3260243 ZINC27554549 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098749 Clc1ccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)cc1 InChI=1S/C18H15ClN2O4/c19-14-5-1-12(2-6-14)3-8-17(22)20-21-18(23)13-4-7-15-16(11-13)25-10-9-24-15/h1-8,11H,9-10H2,(H,20,22)(H,21,23)/b8-3+ XTYDCDUVSAESPJ-FPYGCLRLSA-N 50016499 CHEMBL3260244 Serine/threonine-protein kinase PLK1 Homo sapiens 1550 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016499&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 55461102 103927897 CHEMBL3260244 ZINC29466995 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098750 Cc1ccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)cc1 InChI=1S/C19H18N2O4/c1-13-2-4-14(5-3-13)6-9-18(22)20-21-19(23)15-7-8-16-17(12-15)25-11-10-24-16/h2-9,12H,10-11H2,1H3,(H,20,22)(H,21,23)/b9-6+ FAXITRGBEHCSIB-RMKNXTFCSA-N 50016500 CHEMBL3260246 Serine/threonine-protein kinase PLK1 Homo sapiens 1050 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643722 103927898 CHEMBL3260246 ZINC29465197 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098751 COc1ccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)cc1 InChI=1S/C19H18N2O5/c1-24-15-6-2-13(3-7-15)4-9-18(22)20-21-19(23)14-5-8-16-17(12-14)26-11-10-25-16/h2-9,12H,10-11H2,1H3,(H,20,22)(H,21,23)/b9-4+ HRESQKRNIZIAQQ-RUDMXATFSA-N 50016501 CHEMBL3260247 Serine/threonine-protein kinase PLK1 Homo sapiens 190 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016501&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643723 103927899 CHEMBL3260247 ZINC29465191 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098752 [O-][N+](=O)c1ccc(\C=C\C(=O)NNC(=O)c2ccc3OCCOc3c2)cc1 InChI=1S/C18H15N3O6/c22-17(8-3-12-1-5-14(6-2-12)21(24)25)19-20-18(23)13-4-7-15-16(11-13)27-10-9-26-15/h1-8,11H,9-10H2,(H,19,22)(H,20,23)/b8-3+ MJJUKTUICBQNBI-FPYGCLRLSA-N 50016502 CHEMBL3260248 Serine/threonine-protein kinase PLK1 Homo sapiens 120 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016502&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643724 103927900 CHEMBL3260248 ZINC05647672 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098753 O=C(NNC(=O)c1ccc2OCCOc2c1)\C=C\c1ccccc1 InChI=1S/C18H16N2O4/c21-17(9-6-13-4-2-1-3-5-13)19-20-18(22)14-7-8-15-16(12-14)24-11-10-23-15/h1-9,12H,10-11H2,(H,19,21)(H,20,22)/b9-6+ KOGRIKJYGMBXFL-RMKNXTFCSA-N 50016508 CHEMBL3260249 Serine/threonine-protein kinase PLK1 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016508&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643725 242041648 CHEMBL3260249 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50098754 CC(C)C1=CC(=O)C(\C=N\OC(=O)c2ccccc2C)=CC1=O InChI=1S/C18H17NO4/c1-11(2)15-9-16(20)13(8-17(15)21)10-19-23-18(22)14-7-5-4-6-12(14)3/h4-11H,1-3H3/b19-10+ KRHMAJOTJVOLBI-VXLYETTFSA-N 50016509 CHEMBL3260250 Serine/threonine-protein kinase PLK1 Homo sapiens 2310 ChEMBL 10.1016/j.ejmech.2014.05.026 10.7270/Q2ZP47PK 24859762 Sun, J; Lv, PC; Guo, FJ; Wang, XY; Xiao-Han, na; Zhang, Y; Sheng, GH; Qian, SS; Zhu, HL Nanjing University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50016509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50016509&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 90643726 242041649 CHEMBL3260250 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50109591 CC(C)(C)CNC(=O)CC1CNC(=O)c2cc(cn12)-c1ccsc1 InChI=1S/C18H23N3O2S/c1-18(2,3)11-20-16(22)7-14-8-19-17(23)15-6-13(9-21(14)15)12-4-5-24-10-12/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,19,23)(H,20,22) PNMQDIXULZYDDT-UHFFFAOYSA-N 50021626 CHEMBL3298400 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2013.09.054 10.7270/Q23F4R7S 24139169 Casuscelli, F; Ardini, E; Avanzi, N; Casale, E; Cervi, G; D'Anello, M; Donati, D; Faiardi, D; Ferguson, RD; Fogliatto, G; Galvani, A; Marsiglio, A; Mirizzi, DG; Montemartini, M; Orrenius, C; Papeo, G; Piutti, C; Salom, B; Felder, ER Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021626&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search UGX 4BZN 90645194 103932324 CHEMBL3298400 ZINC26498864 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50109592 CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 InChI=1S/C28H38ClN5O2/c1-32-10-12-33(13-11-32)19-25(20-6-3-2-4-7-20)31-27(35)16-24-17-30-28(36)26-15-22(18-34(24)26)21-8-5-9-23(29)14-21/h5,8-9,14-15,18,20,24-25H,2-4,6-7,10-13,16-17,19H2,1H3,(H,30,36)(H,31,35)/t24-,25+/m0/s1 UKZRGBUTBINTPD-LOSJGSFVSA-N 50021618 CHEMBL3297762::US9145418, 2 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2013.09.054 10.7270/Q23F4R7S 24139169 Casuscelli, F; Ardini, E; Avanzi, N; Casale, E; Cervi, G; D'Anello, M; Donati, D; Faiardi, D; Ferguson, RD; Fogliatto, G; Galvani, A; Marsiglio, A; Mirizzi, DG; Montemartini, M; Orrenius, C; Papeo, G; Piutti, C; Salom, B; Felder, ER Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021618&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71547862 103932316 CHEMBL3297762 ZINC26501564 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50165529 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50166129 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Serine/threonine-protein kinase PLK1 Homo sapiens 220 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50187155 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Serine/threonine-protein kinase PLK1 Homo sapiens 220 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50183362 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50192376 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50196287 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 190 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50197605 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 318 ChEMBL 10.1016/j.bmc.2011.09.042 10.7270/Q2G44QPH 22014755 Kim, H; Kim, M; Lee, J; Yu, H; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50216547 C[C@@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)c1ccccc1C(F)(F)F InChI=1S/C28H27F3N4O2S/c1-16(20-6-4-5-7-23(20)28(29,30)31)37-24-12-18(8-9-21(24)27(33)36)22-11-19(13-34-26(22)32)25-10-17(15-38-25)14-35(2)3/h4-13,15-16H,14H2,1-3H3,(H2,32,34)(H2,33,36)/t16-/m1/s1 DNZGEPPZYMAFLN-MRXNPFEDSA-N 50385916 CHEMBL2042136 Serine/threonine-protein kinase PLK1 Homo sapiens 1320 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385916&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search JUP 4A4X 56947168 160864999 CHEMBL2042136 ZINC84655195 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50216552 C[C@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)\C=C/C(F)(F)F InChI=1S/C24H25F3N4O2S/c1-14(6-7-24(25,26)27)33-20-10-16(4-5-18(20)23(29)32)19-9-17(11-30-22(19)28)21-8-15(13-34-21)12-31(2)3/h4-11,13-14H,12H2,1-3H3,(H2,28,30)(H2,29,32)/b7-6-/t14-/m0/s1 LLEOOSLUHRQCHZ-AFNCTOJWSA-N 50385914 CHEMBL2042042 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57387301 160864997 CHEMBL2042042 ZINC84711742 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221614 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O InChI=1S/C24H23N5O2/c1-24(2,3)29-20-19(21(30)22(20)31)27-18-13-14-25-23(28-18)26-17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-14,29H,1-3H3,(H2,25,26,27,28) NFYCWRMARFWDOP-UHFFFAOYSA-N 50402026 CHEMBL2205457 Serine/threonine-protein kinase PLK1 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402026&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450503 163351050 CHEMBL2205457 ZINC95558196 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221615 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc-4c(Cc5ccccc-45)c3)n2)c(=O)c1=O InChI=1S/C25H23N5O2/c1-25(2,3)30-21-20(22(31)23(21)32)28-19-10-11-26-24(29-19)27-16-8-9-18-15(13-16)12-14-6-4-5-7-17(14)18/h4-11,13,30H,12H2,1-3H3,(H2,26,27,28,29) DZSCOPNYGJCJSL-UHFFFAOYSA-N 50402021 CHEMBL2205458 Serine/threonine-protein kinase PLK1 Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402021&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461303 163351045 CHEMBL2205458 ZINC95560279 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221616 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28) NDIUYMHNCUTVGE-UHFFFAOYSA-N 50402020 CHEMBL2205426 Serine/threonine-protein kinase PLK1 Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402020&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71455860 163351044 CHEMBL2205426 ZINC95563476 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221617 CC(Nc1c(Nc2ccncc2)c(=O)c1=O)C(C)(C)C InChI=1S/C15H19N3O2/c1-9(15(2,3)4)17-11-12(14(20)13(11)19)18-10-5-7-16-8-6-10/h5-9,17H,1-4H3,(H,16,18) IQNOGQGSOHNMCL-UHFFFAOYSA-N 50402022 CHEMBL549730 Serine/threonine-protein kinase PLK1 Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402022&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9881974 163351046 CHEMBL549730 ZINC49627076 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221618 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4ncsc4c3)n2)c(=O)c1=O InChI=1S/C19H18N6O2S/c1-19(2,3)25-15-14(16(26)17(15)27)23-13-6-7-20-18(24-13)22-10-4-5-11-12(8-10)28-9-21-11/h4-9,25H,1-3H3,(H2,20,22,23,24) VDGBGQVBOFMCSF-UHFFFAOYSA-N 50402041 CHEMBL2205464 Serine/threonine-protein kinase PLK1 Homo sapiens 43 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402041&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450505 163351065 CHEMBL2205464 ZINC95559846 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221619 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4OCCc4c3)n2)c(=O)c1=O InChI=1S/C20H21N5O3/c1-20(2,3)25-16-15(17(26)18(16)27)23-14-6-8-21-19(24-14)22-12-4-5-13-11(10-12)7-9-28-13/h4-6,8,10,25H,7,9H2,1-3H3,(H2,21,22,23,24) YXKNRJOHAQUYHN-UHFFFAOYSA-N 50402040 CHEMBL2205465 Serine/threonine-protein kinase PLK1 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402040&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459561 163351064 CHEMBL2205465 ZINC95560580 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221620 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3csnn3)n2)c(=O)c1=O InChI=1S/C20H19N7O2S/c1-20(2,3)25-16-15(17(28)18(16)29)23-14-8-9-21-19(24-14)22-12-6-4-11(5-7-12)13-10-30-27-26-13/h4-10,25H,1-3H3,(H2,21,22,23,24) CAJJNCAGEREFPG-UHFFFAOYSA-N 50402036 CHEMBL2205461 Serine/threonine-protein kinase PLK1 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402036&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461304 163351060 CHEMBL2205461 ZINC95559399 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221621 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4c(c3)[nH]c3ccccc43)n2)c(=O)c1=O InChI=1S/C24H22N6O2/c1-24(2,3)30-20-19(21(31)22(20)32)28-18-10-11-25-23(29-18)26-13-8-9-15-14-6-4-5-7-16(14)27-17(15)12-13/h4-12,27,30H,1-3H3,(H2,25,26,28,29) FVABLEGORONDAP-UHFFFAOYSA-N 50402039 CHEMBL2205462 Serine/threonine-protein kinase PLK1 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402039&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459560 163351063 CHEMBL2205462 ZINC95562564 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221622 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)N3CCOCC3)n2)c(=O)c1=O InChI=1S/C22H26N6O3/c1-22(2,3)27-18-17(19(29)20(18)30)25-16-8-9-23-21(26-16)24-14-4-6-15(7-5-14)28-10-12-31-13-11-28/h4-9,27H,10-13H2,1-3H3,(H2,23,24,25,26) FWSYSJUGLNYDIH-UHFFFAOYSA-N 50402034 CHEMBL2205463 Serine/threonine-protein kinase PLK1 Homo sapiens 175 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402034&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71452347 163351058 CHEMBL2205463 ZINC95563449 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221623 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cn[nH]c3)n2)c(=O)c1=O InChI=1S/C21H21N7O2/c1-21(2,3)28-17-16(18(29)19(17)30)26-15-8-9-22-20(27-15)25-14-6-4-12(5-7-14)13-10-23-24-11-13/h4-11,28H,1-3H3,(H,23,24)(H2,22,25,26,27) FRNPTMFJLAHUDE-UHFFFAOYSA-N 50402044 CHEMBL2205423 Serine/threonine-protein kinase PLK1 Homo sapiens 1610 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402044&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71452343 163351068 CHEMBL2205423 ZINC95561477 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221624 CC(=O)N1CCc2cc(Nc3nccc(Nc4c(NC(C)(C)C)c(=O)c4=O)n3)ccc12 InChI=1S/C22H24N6O3/c1-12(29)28-10-8-13-11-14(5-6-15(13)28)24-21-23-9-7-16(26-21)25-17-18(20(31)19(17)30)27-22(2,3)4/h5-7,9,11,27H,8,10H2,1-4H3,(H2,23,24,25,26) MJCBPVVQRZZEGT-UHFFFAOYSA-N 50402045 CHEMBL2205422 Serine/threonine-protein kinase PLK1 Homo sapiens 1470 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402045&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463025 163351069 CHEMBL2205422 ZINC95563830 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221625 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccn3)n2)c(=O)c1=O InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-11-13-25-22(28-17)26-15-9-7-14(8-10-15)16-6-4-5-12-24-16/h4-13,29H,1-3H3,(H2,25,26,27,28) RKTITQZFTQXTSL-UHFFFAOYSA-N 50402037 CHEMBL2205424 Serine/threonine-protein kinase PLK1 Homo sapiens 82 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402037&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463026 163351061 CHEMBL2205424 ZINC68087746 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221626 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cccnc3)n2)c(=O)c1=O InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-12-25-22(28-17)26-16-8-6-14(7-9-16)15-5-4-11-24-13-15/h4-13,29H,1-3H3,(H2,25,26,27,28) KKOLAOXXRFMPDD-UHFFFAOYSA-N 50402042 CHEMBL2205425 Serine/threonine-protein kinase PLK1 Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402042&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457661 163351066 CHEMBL2205425 ZINC95564201 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221627 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50221628 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4[nH]ncc4c3)n2)c(=O)c1=O InChI=1S/C19H19N7O2/c1-19(2,3)25-15-14(16(27)17(15)28)23-13-6-7-20-18(24-13)22-11-4-5-12-10(8-11)9-21-26-12/h4-9,25H,1-3H3,(H,21,26)(H2,20,22,23,24) GEWGELYHGXTZQJ-UHFFFAOYSA-N 50402046 CHEMBL2205466 Serine/threonine-protein kinase PLK1 Homo sapiens 1470 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402046&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463030 163351070 CHEMBL2205466 ZINC95562272 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50230917 NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1 InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20) VOQXQYXTZZHYBF-UHFFFAOYSA-N 50329427 5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamide::CHEMBL1270230::US9670191, U1 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm100504d 10.7270/Q24T6JM3 20873740 Menichincheri, M; Albanese, C; Alli, C; Ballinari, D; Bargiotti, A; Caldarelli, M; Ciavolella, A; Cirla, A; Colombo, M; Colotta, F; Croci, V; D'Alessio, R; D'Anello, M; Ermoli, A; Fiorentini, F; Forte, B; Galvani, A; Giordano, P; Isacchi, A; Martina, K; Molinari, A; Moll, JK; Montagnoli, A; Orsini, P; Orzi, F; Pesenti, E; Pillan, A; Roletto, F; Scolaro, A; Tato, M; Tibolla, M; Valsasina, B; Varasi, M; Vianello, P; Volpi, D; Santocanale, C; Vanotti, E Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329427&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24809764 123108542 CHEMBL1270230 ZINC64528488 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50230168 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 190 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50227341 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50257919 Oc1ccc(\C=C2\Oc3ccccc3C2=O)cc1O InChI=1S/C15H10O4/c16-11-6-5-9(7-12(11)17)8-14-15(18)10-3-1-2-4-13(10)19-14/h1-8,16-17H/b14-8+ HCBULGQMULJTCM-RIYZIHGNSA-N 50038423 CHEMBL3361128 Serine/threonine-protein kinase PLK1 Homo sapiens 100000 ChEMBL 10.1016/j.ejmech.2014.10.044 10.7270/Q2JQ12NJ 25462247 Xie, F; Zhu, H; Zhang, H; Lang, Q; Tang, L; Huang, Q; Yu, L Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038423&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 21100709 103945796 CHEMBL3361128 ZINC29466236 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50275113 Nc1nc2c3c(F)cccc3nc(Cc3ccc4OCOc4c3)n2n1 InChI=1S/C17H12FN5O2/c18-10-2-1-3-11-15(10)16-21-17(19)22-23(16)14(20-11)7-9-4-5-12-13(6-9)25-8-24-12/h1-6H,7-8H2,(H2,19,22) OWLAKERMHYDWTB-UHFFFAOYSA-N 50048357 CHEMBL3309990 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2014.05.056 10.7270/Q2S46TMD 24980703 Casale, E; Amboldi, N; Brasca, MG; Caronni, D; Colombo, N; Dalvit, C; Felder, ER; Fogliatto, G; Galvani, A; Isacchi, A; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Casuscelli, F Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048357&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search HAJ 4CWR 51037112 313068942 CHEMBL3309990 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50275119 Nc1nc2c3ccc(N)cc3nc(Cc3ccc4OCOc4c3)n2n1 InChI=1S/C17H14N6O2/c18-10-2-3-11-12(7-10)20-15(23-16(11)21-17(19)22-23)6-9-1-4-13-14(5-9)25-8-24-13/h1-5,7H,6,8,18H2,(H2,19,22) FGNQVZZMORDWIZ-UHFFFAOYSA-N 50048362 CHEMBL3309995 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2014.05.056 10.7270/Q2S46TMD 24980703 Casale, E; Amboldi, N; Brasca, MG; Caronni, D; Colombo, N; Dalvit, C; Felder, ER; Fogliatto, G; Galvani, A; Isacchi, A; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Casuscelli, F Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048362&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51036677 313068947 CHEMBL3309995 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50275133 OCCCNc1ccc2c3ncnn3c(nc2c1)-c1ccc2OCOc2c1 InChI=1S/C19H17N5O3/c25-7-1-6-20-13-3-4-14-15(9-13)23-18(24-19(14)21-10-22-24)12-2-5-16-17(8-12)27-11-26-16/h2-5,8-10,20,25H,1,6-7,11H2 GIAVVFIPFBOBRR-UHFFFAOYSA-N 50048364 CHEMBL3309997 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2014.05.056 10.7270/Q2S46TMD 24980703 Casale, E; Amboldi, N; Brasca, MG; Caronni, D; Colombo, N; Dalvit, C; Felder, ER; Fogliatto, G; Galvani, A; Isacchi, A; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Casuscelli, F Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048364&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118706214 313068949 CHEMBL3309997 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50275161 Nc1nc2c3ccc(NCCO)cc3nc(Cc3ccc4OCOc4c3)n2n1 InChI=1S/C19H18N6O3/c20-19-23-18-13-3-2-12(21-5-6-26)9-14(13)22-17(25(18)24-19)8-11-1-4-15-16(7-11)28-10-27-15/h1-4,7,9,21,26H,5-6,8,10H2,(H2,20,24) QPVNTDBWWRFMIC-UHFFFAOYSA-N 50048365 CHEMBL3309998 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2014.05.056 10.7270/Q2S46TMD 24980703 Casale, E; Amboldi, N; Brasca, MG; Caronni, D; Colombo, N; Dalvit, C; Felder, ER; Fogliatto, G; Galvani, A; Isacchi, A; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Casuscelli, F Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048365&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search G3R 4CWS 50938552 313068950 CHEMBL3309998 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50275162 CN1CCN(CC1)c1cc(F)c2c3nc(N)nn3c(Cc3ccc4OCOc4c3)nc2c1 InChI=1S/C22H22FN7O2/c1-28-4-6-29(7-5-28)14-10-15(23)20-16(11-14)25-19(30-21(20)26-22(24)27-30)9-13-2-3-17-18(8-13)32-12-31-17/h2-3,8,10-11H,4-7,9,12H2,1H3,(H2,24,27) QUYGYUVUHYMMRW-UHFFFAOYSA-N 50048374 CHEMBL3310151 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2014.05.056 10.7270/Q2S46TMD 24980703 Casale, E; Amboldi, N; Brasca, MG; Caronni, D; Colombo, N; Dalvit, C; Felder, ER; Fogliatto, G; Galvani, A; Isacchi, A; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Casuscelli, F Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048374&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51037948 313068959 CHEMBL3310151 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50266762 O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccncc3)n[nH]c2c1 InChI=1S/C23H16N4O/c28-23-19(17-3-1-2-4-20(17)25-23)13-16-5-7-18-21(26-27-22(18)14-16)8-6-15-9-11-24-12-10-15/h1-14H,(H,25,28)(H,26,27)/b8-6+,19-13+ CZFUYZPXZGGWKC-SRQUHQSVSA-N 50437838 CHEMBL2407749 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm500537u 10.7270/Q2125V9W 24867403 Sampson, PB; Liu, Y; Patel, NK; Feher, M; Forrest, B; Li, SW; Edwards, L; Laufer, R; Lang, Y; Ban, F; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Mason, JM; Wei, X; Kiarash, R; Green, E; Qiu, W; Chirgadze, NY; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189810 175450155 CHEMBL2407749 ZINC96273691 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50266763 O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccncc3)n[nH]c2c1 50044666 CHEMBL3353340::US10358436, Example A22 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm500537u 10.7270/Q2125V9W 24867403 Sampson, PB; Liu, Y; Patel, NK; Feher, M; Forrest, B; Li, SW; Edwards, L; Laufer, R; Lang, Y; Ban, F; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Mason, JM; Wei, X; Kiarash, R; Green, E; Qiu, W; Chirgadze, NY; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044666&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118987723 313068285 CHEMBL3353340 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50266764 CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1 50044657 CHEMBL3353347::US10358436, Example A24::US9907800, Example A24 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm500537u 10.7270/Q2125V9W 24867403 Sampson, PB; Liu, Y; Patel, NK; Feher, M; Forrest, B; Li, SW; Edwards, L; Laufer, R; Lang, Y; Ban, F; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Mason, JM; Wei, X; Kiarash, R; Green, E; Qiu, W; Chirgadze, NY; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044657&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118987716 313068276 CHEMBL3353347 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50282319 NS(=O)(=O)c1cccc(c1)-c1n[nH]c2ccc(NC(=O)C(N3CCCC3)c3ccsc3)cc12 InChI=1S/C23H23N5O3S2/c24-33(30,31)18-5-3-4-15(12-18)21-19-13-17(6-7-20(19)26-27-21)25-23(29)22(16-8-11-32-14-16)28-9-1-2-10-28/h3-8,11-14,22H,1-2,9-10H2,(H,25,29)(H,26,27)(H2,24,30,31) JBZRAEUHDPMQSF-UHFFFAOYSA-N 50053304 CHEMBL3330410 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1016/j.bmc.2014.06.027 10.7270/Q2K35WB2 25043312 Laufer, R; Ng, G; Liu, Y; Patel, NK; Edwards, LG; Lang, Y; Li, SW; Feher, M; Awrey, DE; Leung, G; Beletskaya, I; Plotnikova, O; Mason, JM; Hodgson, R; Wei, X; Mao, G; Luo, X; Huang, P; Green, E; Kiarash, R; Lin, DC; Harris-Brandts, M; Ban, F; Nadeem, V; Mak, TW; Pan, GJ; Qiu, W; Chirgadze, NY; Pauls, HW University Health Network http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053304&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 101902999 103950016 CHEMBL3330410 ZINC00005831 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50282320 CCc1ccccc1C(N(C)C)C(=O)Nc1ccc2[nH]nc(-c3cccc(c3)S(N)(=O)=O)c2c1 InChI=1S/C25H27N5O3S/c1-4-16-8-5-6-11-20(16)24(30(2)3)25(31)27-18-12-13-22-21(15-18)23(29-28-22)17-9-7-10-19(14-17)34(26,32)33/h5-15,24H,4H2,1-3H3,(H,27,31)(H,28,29)(H2,26,32,33) JAHXQCZCZURPTI-UHFFFAOYSA-N 50053305 CHEMBL3330409 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1016/j.bmc.2014.06.027 10.7270/Q2K35WB2 25043312 Laufer, R; Ng, G; Liu, Y; Patel, NK; Edwards, LG; Lang, Y; Li, SW; Feher, M; Awrey, DE; Leung, G; Beletskaya, I; Plotnikova, O; Mason, JM; Hodgson, R; Wei, X; Mao, G; Luo, X; Huang, P; Green, E; Kiarash, R; Lin, DC; Harris-Brandts, M; Ban, F; Nadeem, V; Mak, TW; Pan, GJ; Qiu, W; Chirgadze, NY; Pauls, HW University Health Network http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50053305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50053305&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 101903000 103950017 CHEMBL3330409 ZINC13758956 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293601 CCN(CC)CC(O)Cn1cc(C(O)=O)c2ccccc12 InChI=1S/C16H22N2O3/c1-3-17(4-2)9-12(19)10-18-11-14(16(20)21)13-7-5-6-8-15(13)18/h5-8,11-12,19H,3-4,9-10H2,1-2H3,(H,20,21) JZGUHPFQSABXEO-UHFFFAOYSA-N 50060905 CHEMBL3394758 Serine/threonine-protein kinase PLK1 Homo sapiens 1910 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060905&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726275 103956517 CHEMBL3394758 ZINC13766603 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293602 OC(CN1CCCCC1)Cn1cc(C(O)=O)c2ccccc12 InChI=1S/C17H22N2O3/c20-13(10-18-8-4-1-5-9-18)11-19-12-15(17(21)22)14-6-2-3-7-16(14)19/h2-3,6-7,12-13,20H,1,4-5,8-11H2,(H,21,22) FJZAHNJWHBXOJX-UHFFFAOYSA-N 50060906 CHEMBL3394759 Serine/threonine-protein kinase PLK1 Homo sapiens 2100 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060906&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726276 103956518 CHEMBL3394759 ZINC27213997 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293603 OC(CN1CCCC1)Cn1cc(C(O)=O)c2ccccc12 InChI=1S/C16H20N2O3/c19-12(9-17-7-3-4-8-17)10-18-11-14(16(20)21)13-5-1-2-6-15(13)18/h1-2,5-6,11-12,19H,3-4,7-10H2,(H,20,21) ZIVMVDLFRZESTI-UHFFFAOYSA-N 50060907 CHEMBL3394760 Serine/threonine-protein kinase PLK1 Homo sapiens 4840 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060907&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726277 103956519 CHEMBL3394760 ZINC13766615 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293604 CN1CCN(CC(O)Cn2cc(C(O)=O)c3ccccc23)CC1 InChI=1S/C17H23N3O3/c1-18-6-8-19(9-7-18)10-13(21)11-20-12-15(17(22)23)14-4-2-3-5-16(14)20/h2-5,12-13,21H,6-11H2,1H3,(H,22,23) FZBGHMKUJJAGBT-UHFFFAOYSA-N 50060908 CHEMBL3394761 Serine/threonine-protein kinase PLK1 Homo sapiens 3470 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060908&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726278 103956520 CHEMBL3394761 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293605 CCN(CC)CC(O)Cn1cc(CC(O)=O)c2ccccc12 InChI=1S/C17H24N2O3/c1-3-18(4-2)11-14(20)12-19-10-13(9-17(21)22)15-7-5-6-8-16(15)19/h5-8,10,14,20H,3-4,9,11-12H2,1-2H3,(H,21,22) XATBCOLGACXQQM-UHFFFAOYSA-N 50060909 CHEMBL3394762 Serine/threonine-protein kinase PLK1 Homo sapiens 2640 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060909&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726279 103956521 CHEMBL3394762 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293606 OC(CN1CCCCC1)Cn1cc(CC(O)=O)c2ccccc12 InChI=1S/C18H24N2O3/c21-15(12-19-8-4-1-5-9-19)13-20-11-14(10-18(22)23)16-6-2-3-7-17(16)20/h2-3,6-7,11,15,21H,1,4-5,8-10,12-13H2,(H,22,23) HNOLYVYDGDGIDD-UHFFFAOYSA-N 50060910 CHEMBL3394763 Serine/threonine-protein kinase PLK1 Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060910&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726280 103956522 CHEMBL3394763 ZINC13766598 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293607 OC(CN1CCCC1)Cn1cc(CC(O)=O)c2ccccc12 InChI=1S/C17H22N2O3/c20-14(11-18-7-3-4-8-18)12-19-10-13(9-17(21)22)15-5-1-2-6-16(15)19/h1-2,5-6,10,14,20H,3-4,7-9,11-12H2,(H,21,22) VFXXPAORMIDACS-UHFFFAOYSA-N 50060911 CHEMBL3394764 Serine/threonine-protein kinase PLK1 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060911&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91938009 103956523 CHEMBL3394764 ZINC13766661 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293608 CN1CCN(CC(O)Cn2cc(CC(O)=O)c3ccccc23)CC1 InChI=1S/C18H25N3O3/c1-19-6-8-20(9-7-19)12-15(22)13-21-11-14(10-18(23)24)16-4-2-3-5-17(16)21/h2-5,11,15,22H,6-10,12-13H2,1H3,(H,23,24) IUESHCGRXYXZSP-UHFFFAOYSA-N 50060912 CHEMBL3394765 Serine/threonine-protein kinase PLK1 Homo sapiens 1880 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060912&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726281 103956524 CHEMBL3394765 ZINC13766633 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293609 OC(CN1CCOCC1)Cn1cc(CC(O)=O)c2ccccc12 InChI=1S/C17H22N2O4/c20-14(11-18-5-7-23-8-6-18)12-19-10-13(9-17(21)22)15-3-1-2-4-16(15)19/h1-4,10,14,20H,5-9,11-12H2,(H,21,22) JHYRCHZGDMGSLM-UHFFFAOYSA-N 50060913 CHEMBL3394766 Serine/threonine-protein kinase PLK1 Homo sapiens 960 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060913&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726282 103956525 CHEMBL3394766 ZINC13766643 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293610 OC(CN1CCCCC1)Cn1cc(CCC(O)=O)c2ccccc12 InChI=1S/C19H26N2O3/c22-16(13-20-10-4-1-5-11-20)14-21-12-15(8-9-19(23)24)17-6-2-3-7-18(17)21/h2-3,6-7,12,16,22H,1,4-5,8-11,13-14H2,(H,23,24) OIKYUBXQDWHHJC-UHFFFAOYSA-N 50060914 CHEMBL3394767 Serine/threonine-protein kinase PLK1 Homo sapiens 5710 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726283 103956526 CHEMBL3394767 ZINC13766635 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293611 OC(CN1CCCC1)Cn1cc(CCC(O)=O)c2ccccc12 InChI=1S/C18H24N2O3/c21-15(12-19-9-3-4-10-19)13-20-11-14(7-8-18(22)23)16-5-1-2-6-17(16)20/h1-2,5-6,11,15,21H,3-4,7-10,12-13H2,(H,22,23) OQQFXVWSINWEED-UHFFFAOYSA-N 50060915 CHEMBL3394768 Serine/threonine-protein kinase PLK1 Homo sapiens 2900 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726284 103956527 CHEMBL3394768 ZINC13766617 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293612 CC(C)C1=CC(=O)C(C)=CC1=O InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3 KEQHJBNSCLWCAE-UHFFFAOYSA-N 166686 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione (F8) Serine/threonine-protein kinase PLK1 Homo sapiens 2180 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=166686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=166686&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IMW 4HCO 10281 312320576 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293617 OC(CN1CCCCC1)Cn1cc(CCC(=O)c2ccccc2)c2ccccc12 InChI=1S/C25H30N2O2/c28-22(18-26-15-7-2-8-16-26)19-27-17-21(23-11-5-6-12-24(23)27)13-14-25(29)20-9-3-1-4-10-20/h1,3-6,9-12,17,22,28H,2,7-8,13-16,18-19H2 MHSBQWAPDZNAST-UHFFFAOYSA-N 50060916 CHEMBL3394757 Serine/threonine-protein kinase PLK1 Homo sapiens 1820 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060916&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118726274 103956528 CHEMBL3394757 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50293618 COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC(O)=O)c2)c(OC)c1 InChI=1S/C21H25NO8S/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24/h5-11,22H,12-13H2,1-4H3,(H,23,24)/b8-7+ OWBFCJROIKNMGD-BQYQJAHWSA-N 50060917 ON-01910::Rigosertib Serine/threonine-protein kinase PLK1 Homo sapiens 9.0 ChEMBL 10.1016/j.bmcl.2014.12.060 10.7270/Q2ZK5JB5 25556101 Liu, M; Huang, J; Chen, DX; Jiang, C China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060917&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6FS 5J18,5OV7,5J2R 6918736 103956529 ZINC13766623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304918 NS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C19H20F2N6O2S/c20-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(21)19(27-18)26-15-9-1-3-10(4-2-9)16(15)30(22,28)29/h5-10,15-16H,1-4H2,(H,23,24)(H2,22,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1 BZIKSZZVJAQWMC-SBBZOCNPSA-N 50067531 CHEMBL3401983 Serine/threonine-protein kinase PLK1 Homo sapiens 2100 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067531&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728819 103961970 CHEMBL3401983 ZINC03791117 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304919 Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4c4nc(=O)o[nH]4)n3)c2c1 InChI=1S/C21H19F2N7O2/c22-11-5-12-13(7-25-17(12)24-6-11)18-26-8-14(23)19(28-18)27-16-10-3-1-9(2-4-10)15(16)20-29-21(31)32-30-20/h5-10,15-16H,1-4H2,(H,24,25)(H,26,27,28)(H,29,30,31)/t9?,10?,15-,16-/m0/s1 YQHXFSMWBWXLGR-SBBZOCNPSA-N 50067520 CHEMBL3401982 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067520&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728818 103961959 CHEMBL3401982 ZINC01996441 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304920 Oc1cc(on1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H20F2N6O2/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(31)30-32-16/h5-11,18-19H,1-4H2,(H,25,26)(H,30,31)(H,27,28,29)/t10?,11?,18-,19+/m1/s1 JYDWJFDOWRSYSW-DJZCKWSOSA-N 50067518 CHEMBL3401981 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067518&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728817 103961957 CHEMBL3401981 ZINC00583793 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304921 CC(=O)NS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H22F2N6O3S/c1-10(30)29-33(31,32)18-12-4-2-11(3-5-12)17(18)27-21-16(23)9-26-20(28-21)15-8-25-19-14(15)6-13(22)7-24-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,24,25)(H,29,30)(H,26,27,28)/t11?,12?,17-,18-/m0/s1 ACXVCLUGFVYVMQ-DFYNNNJYSA-N 50067517 CHEMBL3401980 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067517&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728816 103961956 CHEMBL3401980 ZINC27417770 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304922 Oc1cc(no1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H20F2N6O2/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(31)32-30-16/h5-11,18-19,31H,1-4H2,(H,25,26)(H,27,28,29)/t10?,11?,18-,19+/m1/s1 DFYXXJJSVFEUQI-DJZCKWSOSA-N 50067515 CHEMBL3401979 Serine/threonine-protein kinase PLK1 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067515&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728815 103961954 CHEMBL3401979 ZINC01903043 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304923 Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4Cn4oc(=O)[nH]c4=O)n3)c2c1 InChI=1S/C22H21F2N7O3/c23-12-5-13-14(7-26-18(13)25-6-12)19-27-8-16(24)20(29-19)28-17-11-3-1-10(2-4-11)15(17)9-31-21(32)30-22(33)34-31/h5-8,10-11,15,17H,1-4,9H2,(H,25,26)(H,27,28,29)(H,30,32,33)/t10?,11?,15-,17-/m0/s1 DMGXNXJIKAWOHP-JJIXEQETSA-N 50067514 CHEMBL3401978 Serine/threonine-protein kinase PLK1 Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067514&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728814 103961953 CHEMBL3401978 ZINC13781567 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304924 OP(O)(=O)CC[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H24F2N5O3P/c22-13-7-15-16(9-25-19(15)24-8-13)20-26-10-17(23)21(28-20)27-18-12-3-1-11(2-4-12)14(18)5-6-32(29,30)31/h7-12,14,18H,1-6H2,(H,24,25)(H,26,27,28)(H2,29,30,31)/t11?,12?,14-,18-/m0/s1 YQXSREGMIKNZEU-TZQPCPOVSA-N 50067513 CHEMBL3401977 Serine/threonine-protein kinase PLK1 Homo sapiens 320 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067513&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728813 103961952 CHEMBL3401977 ZINC00580262 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304925 OP(O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C19H20F2N5O3P/c20-11-5-12-13(7-23-17(12)22-6-11)18-24-8-14(21)19(26-18)25-15-9-1-3-10(4-2-9)16(15)30(27,28)29/h5-10,15-16H,1-4H2,(H,22,23)(H,24,25,26)(H2,27,28,29)/t9?,10?,15-,16-/m0/s1 UXVRWSBRRRIFQG-SBBZOCNPSA-N 50067542 CHEMBL3401976 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067542&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728812 103961981 CHEMBL3401976 ZINC27427032 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304926 Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4c4nnn[nH]4)n3)c2c1 InChI=1S/C20H19F2N9/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20-28-30-31-29-20/h5-10,15-16H,1-4H2,(H,23,24)(H,25,26,27)(H,28,29,30,31)/t9?,10?,15-,16-/m0/s1 GUZDKGKFDUYPQP-SBBZOCNPSA-N 50067541 CHEMBL3401975 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067541&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728811 103961980 CHEMBL3401975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304927 OCC(O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H23F2N5O2/c22-12-5-13-14(7-25-19(13)24-6-12)20-26-8-15(23)21(28-20)27-18-11-3-1-10(2-4-11)17(18)16(30)9-29/h5-8,10-11,16-18,29-30H,1-4,9H2,(H,24,25)(H,26,27,28)/t10?,11?,16?,17-,18+/m1/s1 VAPOMSIOLKMAIW-DBPFDUESSA-N 50067533 CHEMBL3401984 Serine/threonine-protein kinase PLK1 Homo sapiens 510 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728820 103961972 CHEMBL3401984 ZINC13781582 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304930 CS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C20H21F2N5O2S/c1-30(28,29)17-11-4-2-10(3-5-11)16(17)26-20-15(22)9-25-19(27-20)14-8-24-18-13(14)6-12(21)7-23-18/h6-11,16-17H,2-5H2,1H3,(H,23,24)(H,25,26,27)/t10?,11?,16-,17-/m0/s1 PMGPBZHUTBKGCZ-VOGSPBGVSA-N 50067540 CHEMBL3401990 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067540&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728826 103961979 CHEMBL3401990 ZINC27432272 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304932 Cc1nnc(o1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H21F2N7O/c1-10-30-31-22(32-10)17-11-2-4-12(5-3-11)18(17)28-21-16(24)9-27-20(29-21)15-8-26-19-14(15)6-13(23)7-25-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,25,26)(H,27,28,29)/t11?,12?,17-,18-/m0/s1 WIMOLDAKNKMBFB-DFYNNNJYSA-N 50067539 CHEMBL3401989 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067539&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728825 103961978 CHEMBL3401989 ZINC27427996 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304934 Cc1noc(n1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H21F2N7O/c1-10-28-22(32-31-10)17-11-2-4-12(5-3-11)18(17)29-21-16(24)9-27-20(30-21)15-8-26-19-14(15)6-13(23)7-25-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,25,26)(H,27,29,30)/t11?,12?,17-,18-/m0/s1 IYFIEJRWVMLGOG-DFYNNNJYSA-N 50067538 CHEMBL3401988 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067538&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728824 103961977 CHEMBL3401988 ZINC27430272 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304942 CC(O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H23F2N5O/c1-10(29)17-11-2-4-12(5-3-11)18(17)27-21-16(23)9-26-20(28-21)15-8-25-19-14(15)6-13(22)7-24-19/h6-12,17-18,29H,2-5H2,1H3,(H,24,25)(H,26,27,28)/t10?,11?,12?,17-,18-/m0/s1 UVHNIMCYDWMRAE-LOTSEXGMSA-N 50067537 CHEMBL3401987 Serine/threonine-protein kinase PLK1 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067537&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728823 103961976 CHEMBL3401987 ZINC27424532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304944 CNC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H22F2N6O/c1-24-21(30)16-10-2-4-11(5-3-10)17(16)28-20-15(23)9-27-19(29-20)14-8-26-18-13(14)6-12(22)7-25-18/h6-11,16-17H,2-5H2,1H3,(H,24,30)(H,25,26)(H,27,28,29)/t10?,11?,16-,17-/m0/s1 FQAOJJZIGINGIO-VOGSPBGVSA-N 50067535 CHEMBL3401986 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067535&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728822 103961974 CHEMBL3401986 ZINC03781115 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50304946 Oc1cc([nH]n1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H21F2N7O/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(32)31-30-16/h5-11,18-19H,1-4H2,(H,25,26)(H,27,28,29)(H2,30,31,32)/t10?,11?,18-,19+/m1/s1 NHGXNIGDTNEHGJ-DJZCKWSOSA-N 50067534 CHEMBL3401985 Serine/threonine-protein kinase PLK1 Homo sapiens 1700 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118728821 103961973 CHEMBL3401985 ZINC13781583 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50325396 COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 50073587 CHEMBL3408947::US10358436, Example A185::US9907800, Example A185 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1016/j.ejmech.2015.03.020 10.7270/Q2NG4SBV 25791677 Yu, B; Yu, Z; Qi, PP; Yu, DQ; Liu, HM Zhengzhou University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073587&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118987958 313072907 CHEMBL3408947 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323869 COC(=O)c1cc2c(CN3CCCCC3)n[nH]c2s1 InChI=1S/C13H17N3O2S/c1-18-13(17)11-7-9-10(14-15-12(9)19-11)8-16-5-3-2-4-6-16/h7H,2-6,8H2,1H3,(H,14,15) KMIHVDIUSIWJBR-UHFFFAOYSA-N 50175233 CHEMBL200348::methyl 3-(piperidin-1-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175233&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405987 104060972 CHEMBL200348 ZINC28564902 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323884 Cc1[nH]nc2sc(C(N)=O)c(NC(=O)c3ccc(Cl)cc3)c12 InChI=1S/C14H11ClN4O2S/c1-6-9-10(11(12(16)20)22-14(9)19-18-6)17-13(21)7-2-4-8(15)5-3-7/h2-5H,1H3,(H2,16,20)(H,17,21)(H,18,19) ZCJZGTHJIXYVGG-UHFFFAOYSA-N 50175244 4-(4-chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide::CHEMBL199658 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175244&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405946 104060983 CHEMBL199658 ZINC28564947 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323892 CC(=O)Nc1c(sc2n[nH]c(C)c12)C(N)=O InChI=1S/C9H10N4O2S/c1-3-5-6(11-4(2)14)7(8(10)15)16-9(5)13-12-3/h1-2H3,(H2,10,15)(H,11,14)(H,12,13) ALIXTVBPMHJTAF-UHFFFAOYSA-N 50175236 4-acetamido-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide::CHEMBL199737 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175236&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406019 104060975 CHEMBL199737 ZINC28565111 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323908 CCCCN(C)C(=O)c1cc2c(n[nH]c2s1)-c1ccccc1 InChI=1S/C17H19N3OS/c1-3-4-10-20(2)17(21)14-11-13-15(18-19-16(13)22-14)12-8-6-5-7-9-12/h5-9,11H,3-4,10H2,1-2H3,(H,18,19) DCRJMZNHTPDFNQ-UHFFFAOYSA-N 50175237 CHEMBL199528::N-butyl-N-methyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175237&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11645322 104060976 CHEMBL199528 ZINC28564943 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323921 COC(=O)c1cc2c(Nc3ccccc3)[nH]nc2s1 InChI=1S/C13H11N3O2S/c1-18-13(17)10-7-9-11(15-16-12(9)19-10)14-8-5-3-2-4-6-8/h2-7H,1H3,(H2,14,15,16) WIVJBVXMFDYZEO-UHFFFAOYSA-N 50175251 CHEMBL200796::methyl 3-(phenylamino)-1H-thieno[2,3-c]pyrazole-5-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens 21000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175251&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405983 104060990 CHEMBL200796 ZINC28564888 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323923 Cc1[nH]nc2sc(C(N)=O)c(NC(=O)Nc3ccccc3)c12 InChI=1S/C14H13N5O2S/c1-7-9-10(11(12(15)20)22-13(9)19-18-7)17-14(21)16-8-5-3-2-4-6-8/h2-6H,1H3,(H2,15,20)(H,18,19)(H2,16,17,21) GSCAIAFNYPEEIT-UHFFFAOYSA-N 50175245 1-(5-carbamoyl-3-methyl-1H-thieno[2,3-c]pyrazol-4-yl)-3-phenylurea::CHEMBL199996 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175245&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405949 104060984 CHEMBL199996 ZINC28564954 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323924 Cc1[nH]nc2sc(C(N)=O)c(NC(=O)COc3ccccc3)c12 InChI=1S/C15H14N4O3S/c1-8-11-12(13(14(16)21)23-15(11)19-18-8)17-10(20)7-22-9-5-3-2-4-6-9/h2-6H,7H2,1H3,(H2,16,21)(H,17,20)(H,18,19) CAVFEAKOYPWCSA-UHFFFAOYSA-N 50175252 3-methyl-4-(2-phenoxyacetamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide::CHEMBL199759 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175252&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406048 104060991 CHEMBL199759 ZINC28565173 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323925 O=C(NC1CCCCC1)c1cc2c(n[nH]c2s1)-c1ccccc1 InChI=1S/C18H19N3OS/c22-17(19-13-9-5-2-6-10-13)15-11-14-16(20-21-18(14)23-15)12-7-3-1-4-8-12/h1,3-4,7-8,11,13H,2,5-6,9-10H2,(H,19,22)(H,20,21) MLSDGZDBIVDXEE-UHFFFAOYSA-N 50175239 CHEMBL199755::N-cyclohexyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens 12000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175239&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406074 104060978 CHEMBL199755 ZINC28565132 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323928 Cc1n[nH]c2sc(cc12)C(N)=O InChI=1S/C7H7N3OS/c1-3-4-2-5(6(8)11)12-7(4)10-9-3/h2H,1H3,(H2,8,11)(H,9,10) MELHJKUYOBXOER-UHFFFAOYSA-N 50175238 3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide::CHEMBL198022 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175238&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405988 104060977 CHEMBL198022 ZINC28565047 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323932 CN1CCN(CC1)C(=O)c1cc2c(n[nH]c2s1)-c1ccccc1 InChI=1S/C17H18N4OS/c1-20-7-9-21(10-8-20)17(22)14-11-13-15(18-19-16(13)23-14)12-5-3-2-4-6-12/h2-6,11H,7-10H2,1H3,(H,18,19) UJXSEZDSHGPMOE-UHFFFAOYSA-N 50175232 (4-methylpiperazin-1-yl)(3-phenyl-1H-thieno[2,3-c]pyrazol-5-yl)methanone::CHEMBL371239 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175232&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406018 104060971 CHEMBL371239 ZINC28565109 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323935 COC(=O)c1cc2c(C)n[nH]c2s1 InChI=1S/C8H8N2O2S/c1-4-5-3-6(8(11)12-2)13-7(5)10-9-4/h3H,1-2H3,(H,9,10) MWEIZALZQKSIDX-UHFFFAOYSA-N 50175248 CHEMBL200586::methyl 3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175248&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405982 104060987 CHEMBL200586 ZINC28564886 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323936 O=C(NCCc1ccccc1)c1cc2c(n[nH]c2s1)-c1ccccc1 InChI=1S/C20H17N3OS/c24-19(21-12-11-14-7-3-1-4-8-14)17-13-16-18(22-23-20(16)25-17)15-9-5-2-6-10-15/h1-10,13H,11-12H2,(H,21,24)(H,22,23) COQMBZDAQWGIGH-UHFFFAOYSA-N 50175234 CHEMBL197923::N-phenethyl-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens 17000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175234&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406013 104060973 CHEMBL197923 ZINC28565097 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323951 CCCCNC(=O)c1cc2c(C)n[nH]c2s1 InChI=1S/C11H15N3OS/c1-3-4-5-12-10(15)9-6-8-7(2)13-14-11(8)16-9/h6H,3-5H2,1-2H3,(H,12,15)(H,13,14) MNXLTLCOWQQAKN-UHFFFAOYSA-N 50175249 CHEMBL371242::N-butyl-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175249&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405938 104060988 CHEMBL371242 ZINC28564782 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323955 Cc1n[nH]c2sc(cc12)C(=O)NCc1ccccc1 InChI=1S/C14H13N3OS/c1-9-11-7-12(19-14(11)17-16-9)13(18)15-8-10-5-3-2-4-6-10/h2-7H,8H2,1H3,(H,15,18)(H,16,17) KASGWSVWRRHWBU-UHFFFAOYSA-N 50175243 CHEMBL373001::N-benzyl-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens 16000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175243&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405941 104060982 CHEMBL373001 ZINC28564935 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323962 Cc1[nH]nc2sc(C(N)=O)c(NC(=O)c3cccs3)c12 InChI=1S/C12H10N4O2S2/c1-5-7-8(14-11(18)6-3-2-4-19-6)9(10(13)17)20-12(7)16-15-5/h2-4H,1H3,(H2,13,17)(H,14,18)(H,15,16) CFCOQYROFLFNOU-UHFFFAOYSA-N 50175246 3-methyl-4-(thiophene-2-carboxamido)-1H-thieno[2,3-c]pyrazole-5-carboxamide::CHEMBL382070 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175246&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406055 104060985 CHEMBL382070 ZINC28565074 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323963 COc1ccc(CNC(=O)c2cc3c(n[nH]c3s2)-c2ccccc2)cc1 InChI=1S/C20H17N3O2S/c1-25-15-9-7-13(8-10-15)12-21-19(24)17-11-16-18(22-23-20(16)26-17)14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,21,24)(H,22,23) OJLPXQRQXJPIKO-UHFFFAOYSA-N 50175241 CHEMBL199383::N-(4-methoxybenzyl)-3-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175241&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406014 104060980 CHEMBL199383 ZINC28564987 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323968 Cc1[nH]nc2sc(C(N)=O)c(NC(=O)c3ccccc3Cl)c12 InChI=1S/C14H11ClN4O2S/c1-6-9-10(11(12(16)20)22-14(9)19-18-6)17-13(21)7-4-2-3-5-8(7)15/h2-5H,1H3,(H2,16,20)(H,17,21)(H,18,19) UPGDJDYZVVFRFD-UHFFFAOYSA-N 50175235 4-(2-chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide::CHEMBL371695 Serine/threonine-protein kinase PLK1 Homo sapiens 23000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175235&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405999 104060974 CHEMBL371695 ZINC28564927 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323969 COC(=O)C(=O)Nc1c(sc2n[nH]c(C)c12)C(N)=O InChI=1S/C10H10N4O4S/c1-3-4-5(12-8(16)10(17)18-2)6(7(11)15)19-9(4)14-13-3/h1-2H3,(H2,11,15)(H,12,16)(H,13,14) LKKGYKDFEPORRK-UHFFFAOYSA-N 50175250 CHEMBL370199::methyl 2-(5-carbamoyl-3-methyl-1H-thieno[2,3-c]pyrazol-4-ylamino)-2-oxoacetate Serine/threonine-protein kinase PLK1 Homo sapiens 8000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175250&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44406047 104060989 CHEMBL370199 ZINC28565171 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323984 Cc1n[nH]c2sc(cc12)C(=O)NC1CCCCC1 InChI=1S/C13H17N3OS/c1-8-10-7-11(18-13(10)16-15-8)12(17)14-9-5-3-2-4-6-9/h7,9H,2-6H2,1H3,(H,14,17)(H,15,16) SGCQJCPNXKHNPH-UHFFFAOYSA-N 50175240 CHEMBL199951::N-cyclohexyl-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175240&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405940 104060979 CHEMBL199951 ZINC28564933 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323989 CCCCN(C)C(=O)c1cc2c(C)n[nH]c2s1 InChI=1S/C12H17N3OS/c1-4-5-6-15(3)12(16)10-7-9-8(2)13-14-11(9)17-10/h7H,4-6H2,1-3H3,(H,13,14) ORWCFWCLFTZXTR-UHFFFAOYSA-N 50175242 CHEMBL200657::N-butyl-N,3-dimethyl-1H-thieno[2,3-c]pyrazole-5-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175242&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405939 104060981 CHEMBL200657 ZINC28564931 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50323996 Cc1[nH]nc2sc(C(N)=O)c(NC(=O)c3cccc(Cl)c3)c12 InChI=1S/C14H11ClN4O2S/c1-6-9-10(11(12(16)20)22-14(9)19-18-6)17-13(21)7-3-2-4-8(15)5-7/h2-5H,1H3,(H2,16,20)(H,17,21)(H,18,19) QEWMJARXNKOXMM-UHFFFAOYSA-N 50175253 4-(3-chlorobenzamido)-3-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide::CHEMBL199657 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2005.09.042 10.7270/Q2JH3KRS 16216502 Akritopoulou-Zanze, I; Darczak, D; Sarris, K; Phelan, KM; Huth, JR; Song, D; Johnson, EF; Jia, Y; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50175253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50175253&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44405945 104060992 CHEMBL199657 ZINC28564945 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50361571 Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2occ(-c3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)c12 InChI=1S/C27H19F4N5O4S/c28-21-9-6-16(27(29,30)31)11-22(21)36-26(37)35-17-7-4-14(5-8-17)20-13-40-24-19(12-34-25(32)23(20)24)15-2-1-3-18(10-15)41(33,38)39/h1-13H,(H2,32,34)(H2,33,38,39)(H2,35,36,37) CASSAPBDIVDPCC-UHFFFAOYSA-N 50195876 3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenyl}-furo[3,2-c]pyridin-7-yl)-benzenesulfonamide::CHEMBL241682 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.050 10.7270/Q2SB45D5 17027260 Miyazaki, Y; Nakano, M; Sato, H; Truesdale, AT; Stuart, JD; Nartey, EN; Hightower, KE; Kane-Carson, L GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195876&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9938299 104077823 CHEMBL241682 ZINC28884886 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50361586 Nc1ncc(-c2cccc(c2)S(N)(=O)=O)c2scc(-c3ccc(F)c(Cl)c3)c12 InChI=1S/C19H13ClFN3O2S2/c20-15-7-11(4-5-16(15)21)14-9-27-18-13(8-24-19(22)17(14)18)10-2-1-3-12(6-10)28(23,25)26/h1-9H,(H2,22,24)(H2,23,25,26) PILHXMMEJPSZLL-UHFFFAOYSA-N 50195879 3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c]pyridin-7-yl)benzenesulfonamide::CHEMBL241517 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.050 10.7270/Q2SB45D5 17027260 Miyazaki, Y; Nakano, M; Sato, H; Truesdale, AT; Stuart, JD; Nartey, EN; Hightower, KE; Kane-Carson, L GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195879&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11281930 104077826 CHEMBL241517 ZINC28884841 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50366815 O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 CZQHHVNHHHRRDU-UHFFFAOYSA-N 12915 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one::2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one::CHEMBL98350::LY294002::US10308662, Compound LY294002::US9505780, LY294002 Serine/threonine-protein kinase PLK1 Homo sapiens 2100 ChEMBL 10.1074/jbc.M609603200 10.7270/Q2QV3M8X 17135248 Liu, Y; Jiang, N; Wu, J; Dai, W; Rosenblum, JS ActivX Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search LY2 1E7V,1YI3,4AZT,4CFK,6G0D 3973 46509407 65329 CHEMBL98350 DB02656 6004 C15195 ZINC37858693 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50366816 COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 QDLHCMPXEPAAMD-QAIWCSMKSA-N 15234 (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate::CHEMBL428496::NSC221019::Wortmannin::Wortmannin, Wm::cid_312145 Serine/threonine-protein kinase PLK1 Homo sapiens 5.8 ChEMBL 10.1074/jbc.M609603200 10.7270/Q2QV3M8X 17135248 Liu, Y; Jiang, N; Wu, J; Dai, W; Rosenblum, JS ActivX Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15234&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search KWT 3HHM,1E7U,7OTV,3D5X 312145 46515542 52289 CHEMBL428496 DB08059 6060 C15181 ZINC01619592 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50367489 COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25) CZGMEOAMQWAJOY-UHFFFAOYSA-N 47167 CHEMBL201511::US8957103, Z1::US9364459, A Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm0609871 10.7270/Q2NZ8794 17149885 Peifer, C; Krasowski, A; Hammerle, N; Kohlbacher, O; Dannhardt, G; Totzke, F; Schachtele, C; Laufer, S Eberhard-Karls University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=47167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=47167&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11530963 252148178 CHEMBL201511 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50396286 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)c(OC)c3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-19-10-11-21(24(16-19)38-4)26(36)30-18-12-14-33(2)15-13-18/h10-11,16-18,20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 PTCKKLKSUNCGCE-JOCHJYFZSA-N 50112340 CHEMBL3609310 Serine/threonine-protein kinase PLK1 Homo sapiens 0.520000 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112340&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 122187523 319493555 CHEMBL3609310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50396287 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC3CCCC3)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C32H45N7O3/c1-4-26-31(41)38(3)27-20-33-32(36-29(27)39(26)23-9-5-6-10-23)35-25-14-13-21(19-28(25)42-24-11-7-8-12-24)30(40)34-22-15-17-37(2)18-16-22/h13-14,19-20,22-24,26H,4-12,15-18H2,1-3H3,(H,34,40)(H,33,35,36)/t26-/m1/s1 OTKIKJDBYKBEOE-AREMUKBSSA-N 50112344 CHEMBL3609314 Serine/threonine-protein kinase PLK1 Homo sapiens 0.840000 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112344&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118277818 319493559 CHEMBL3609314 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50396288 CC[C@H]1N(C2CCCC2)c2nc(Oc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H38N6O4/c1-5-21-27(36)33(3)22-17-29-28(31-25(22)34(21)20-8-6-7-9-20)38-23-11-10-18(16-24(23)37-4)26(35)30-19-12-14-32(2)15-13-19/h10-11,16-17,19-21H,5-9,12-15H2,1-4H3,(H,30,35)/t21-/m1/s1 MLSIWMLVUIWYLH-OAQYLSRUSA-N 50112345 CHEMBL3609315 Serine/threonine-protein kinase PLK1 Homo sapiens 240 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112345&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118288047 319493560 CHEMBL3609315 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50394704 COc1cc(ccc1N)-c1ccc2c(Nc3ccc(cc3NC2=O)C(C)(C)C(=O)Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C34H35N5O4/c1-34(2,33(41)36-24-7-9-25(10-8-24)39-14-16-43-17-15-39)23-6-13-28-30(20-23)38-32(40)26-11-4-21(18-29(26)37-28)22-5-12-27(35)31(19-22)42-3/h4-13,18-20,37H,14-17,35H2,1-3H3,(H,36,41)(H,38,40) UWHWQUTVFLDMPJ-UHFFFAOYSA-N 50218709 2-[3-(3-methoxy-4-nitrophenyl)-11-oxo-10,11-dihydro-5Hdibenzo[b,e][1,4]diazepin-8-yl]-2-methyl-N-(4-morpholin-4-ylphenyl)propanamide::CHEMBL389745 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm070105d 10.7270/Q22J6BKS 17658776 Wang, L; Sullivan, GM; Hexamer, LA; Hasvold, LA; Thalji, R; Przytulinska, M; Tao, ZF; Li, G; Chen, Z; Xiao, Z; Gu, WZ; Xue, J; Bui, MH; Merta, P; Kovar, P; Bouska, JJ; Zhang, H; Park, C; Stewart, KD; Sham, HL; Sowin, TJ; Rosenberg, SH; Lin, NH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50218709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50218709&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44427519 104092268 CHEMBL389745 ZINC28710755 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50395945 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.220000 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50395946 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(CC)C1=O InChI=1S/C29H41N7O3/c1-5-23-28(38)35(6-2)24-18-30-29(33-26(24)36(23)21-9-7-8-10-21)32-22-12-11-19(17-25(22)39-4)27(37)31-20-13-15-34(3)16-14-20/h11-12,17-18,20-21,23H,5-10,13-16H2,1-4H3,(H,31,37)(H,30,32,33)/t23-/m1/s1 KHVSTZSCKUIMFH-HSZRJFAPSA-N 50112331 CHEMBL3609300 Serine/threonine-protein kinase PLK1 Homo sapiens 0.910000 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112331&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118288049 319493546 CHEMBL3609300 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50395947 CC[C@@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m0/s1 XQVVPGYIWAGRNI-QFIPXVFZSA-N 50112336 CHEMBL3609305 Serine/threonine-protein kinase PLK1 Homo sapiens 0.420000 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112336&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 86295201 319493551 CHEMBL3609305 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50396010 COc1cc(ccc1Nc1ncc2N(Cc3ccccc3)C(=O)[C@@H](Cc3ccccc3)N(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C39H45N7O3/c1-44-21-19-30(20-22-44)41-37(47)29-17-18-32(35(24-29)49-2)42-39-40-25-34-36(43-39)46(31-15-9-10-16-31)33(23-27-11-5-3-6-12-27)38(48)45(34)26-28-13-7-4-8-14-28/h3-8,11-14,17-18,24-25,30-31,33H,9-10,15-16,19-23,26H2,1-2H3,(H,41,47)(H,40,42,43)/t33-/m1/s1 PHDAIHPODSWMSQ-MGBGTMOVSA-N 50112337 CHEMBL3609306 Serine/threonine-protein kinase PLK1 Homo sapiens 4.2 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112337&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 122187520 319493552 CHEMBL3609306 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50396134 CC[C@H]1N(CC(C)C)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C27H39N7O3/c1-7-21-26(36)33(5)22-15-28-27(31-24(22)34(21)16-17(2)3)30-20-9-8-18(14-23(20)37-6)25(35)29-19-10-12-32(4)13-11-19/h8-9,14-15,17,19,21H,7,10-13,16H2,1-6H3,(H,29,35)(H,28,30,31)/t21-/m1/s1 RZFGZSWFNYQBMG-OAQYLSRUSA-N 50112338 CHEMBL3609307 Serine/threonine-protein kinase PLK1 Homo sapiens 7.0 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112338&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 122187521 319493553 CHEMBL3609307 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50396146 CC[C@H]1N(Cc2cccc(Br)c2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C30H36BrN7O3/c1-5-24-29(40)37(3)25-17-32-30(35-27(25)38(24)18-19-7-6-8-21(31)15-19)34-23-10-9-20(16-26(23)41-4)28(39)33-22-11-13-36(2)14-12-22/h6-10,15-17,22,24H,5,11-14,18H2,1-4H3,(H,33,39)(H,32,34,35)/t24-/m1/s1 RCDQFASKGQECOZ-XMMPIXPASA-N 50112339 CHEMBL3609308 Serine/threonine-protein kinase PLK1 Homo sapiens 5.8 ChEMBL 10.1021/acsmedchemlett.5b00084 10.7270/Q2FF3V4D 26191363 Chen, L; Yap, JL; Yoshioka, M; Lanning, ME; Fountain, RN; Raje, M; Scheenstra, JA; Strovel, JW; Fletcher, S University of Maryland http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112339&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 122187522 319493554 CHEMBL3609308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50399137 NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12 InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27) ARYVAQSYRLZVQD-UHFFFAOYSA-N 138348 US8877944, 99 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00680 10.7270/Q2JD4ZKF 26222319 Papeo, G; Posteri, H; Borghi, D; Busel, AA; Caprera, F; Casale, E; Ciomei, M; Cirla, A; Corti, E; D'Anello, M; Fasolini, M; Forte, B; Galvani, A; Isacchi, A; Khvat, A; Krasavin, MY; Lupi, R; Orsini, P; Perego, R; Pesenti, E; Pezzetta, D; Rainoldi, S; Riccardi-Sirtori, F; Scolaro, A; Sola, F; Zuccotto, F; Felder, ER; Donati, D; Montagnoli, A Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=138348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=138348&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search D7N 4ZZY,5A00 49843531 249815573 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50414720 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 192 ChEMBL 10.1016/j.ejmech.2015.08.031 10.7270/Q2XG9SXV 26318067 Im, D; Jung, K; Yang, S; Aman, W; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430238 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.8 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430239 CCN1C(=O)[C@H](CNc2ccc(NC(=O)NCCN3CCCC3)cc2)S\C1=C(\C#N)C(=O)OCC=C InChI=1S/C25H32N6O4S/c1-3-15-35-24(33)20(16-26)23-31(4-2)22(32)21(36-23)17-28-18-7-9-19(10-8-18)29-25(34)27-11-14-30-12-5-6-13-30/h3,7-10,21,28H,1,4-6,11-15,17H2,2H3,(H2,27,29,34)/b23-20-/t21-/m0/s1 PZEVZIABHWNVMI-HWNIBJRTSA-N 50263317 (S)-allyl 2-cyano-2-(3-ethyl-4-oxo-5-((4-(3-(2-(pyrrolidin-1-yl)ethyl)ureido)phenylamino)methyl)thiazolidin-2-ylidene)acetate::CHEMBL477407 Serine/threonine-protein kinase PLK1 Homo sapiens 23 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263317&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44578858 104111713 CHEMBL477407 ZINC40918335 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430240 CCN1C(=O)C(CNc2ccc(cc2)C(C)=O)S\C1=C(\C#N)C(=O)OCC=C InChI=1S/C20H21N3O4S/c1-4-10-27-20(26)16(11-21)19-23(5-2)18(25)17(28-19)12-22-15-8-6-14(7-9-15)13(3)24/h4,6-9,17,22H,1,5,10,12H2,2-3H3/b19-16- YIDXKEGWLMTUBI-MNDPQUGUSA-N 50263318 CHEMBL477408::allyl 2-(5-((4-acetylphenylamino)methyl)-3-ethyl-4-oxothiazolidin-2-ylidene)-2-cyanoacetate Serine/threonine-protein kinase PLK1 Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263318&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44578859 104111714 CHEMBL477408 ZINC40403708 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430241 CCN(CC)CCNC(=O)c1c[nH]c2ccc(N\C=c3\s\c(=C(\C#N)C(=O)NCC(F)(F)F)n(CC)c3=O)cc12 InChI=1S/C26H30F3N7O3S/c1-4-35(5-2)10-9-31-23(38)19-13-33-20-8-7-16(11-17(19)20)32-14-21-24(39)36(6-3)25(40-21)18(12-30)22(37)34-15-26(27,28)29/h7-8,11,13-14,32-33H,4-6,9-10,15H2,1-3H3,(H,31,38)(H,34,37)/b21-14+,25-18- FPPKKTYWKBNCQJ-HSVWJNBRSA-N 50263356 5-((2-(1-cyano-2-oxo-2-(2,2,2-trifluoroethylamino)ethylidene)-3-ethyl-4-oxothiazolidin-5-ylidene)methylamino)-N-(2-(diethylamino)ethyl)-1H-indole-3-carboxamide::CHEMBL475881 Serine/threonine-protein kinase PLK1 Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263356&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44578906 104111744 CHEMBL475881 ZINC14210202 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430242 CCn1c(=O)\c(=C/Nc2ccc(OCCN(C)C)cc2)s\c1=C(\C#N)C(=O)NC#C InChI=1S/C21H23N5O3S/c1-5-23-19(27)17(13-22)21-26(6-2)20(28)18(30-21)14-24-15-7-9-16(10-8-15)29-12-11-25(3)4/h1,7-10,14,24H,6,11-12H2,2-4H3,(H,23,27)/b18-14+,21-17- KCJLPAPNPPTIHO-XBJGNNPPSA-N 50263442 2-cyano-2-(5-((4-(2-(dimethylamino)ethoxy)phenylamino)methylene)-3-ethyl-4-oxothiazolidin-2-ylidene)-N-ethynylacetamide::CHEMBL514371 Serine/threonine-protein kinase PLK1 Homo sapiens 71 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263442&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579005 104111794 CHEMBL514371 ZINC40918316 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430243 CCn1c(=O)\c(=C/Nc2ccc(OCCN(C)C)cc2)s\c1=C(\C#N)C(=O)NCC(F)F InChI=1S/C21H25F2N5O3S/c1-4-28-20(30)17(32-21(28)16(11-24)19(29)26-13-18(22)23)12-25-14-5-7-15(8-6-14)31-10-9-27(2)3/h5-8,12,18,25H,4,9-10,13H2,1-3H3,(H,26,29)/b17-12+,21-16- YPPNNZHHZBVSQS-LRAWPCGGSA-N 50263443 2-cyano-N-(2,2-difluoroethyl)-2-(5-((4-(2-(dimethylamino)ethoxy)phenylamino)methylene)-3-ethyl-4-oxothiazolidin-2-ylidene)acetamide::CHEMBL515457 Serine/threonine-protein kinase PLK1 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263443&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579006 104111795 CHEMBL515457 ZINC14024313 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430244 CCn1c(=O)\c(=C/Nc2ccc(CCN3CCCC3)cc2)s\c1=C(\C#N)C(=O)NCC(F)(F)F InChI=1S/C23H26F3N5O2S/c1-2-31-21(33)19(34-22(31)18(13-27)20(32)29-15-23(24,25)26)14-28-17-7-5-16(6-8-17)9-12-30-10-3-4-11-30/h5-8,14,28H,2-4,9-12,15H2,1H3,(H,29,32)/b19-14+,22-18- PSZRHKVUKTZGRB-DWKLJOBNSA-N 50263444 2-cyano-2-(3-ethyl-4-oxo-5-((4-(2-(pyrrolidin-1-yl)ethyl)phenylamino)methylene)thiazolidin-2-ylidene)-N-(2,2,2-trifluoroethyl)acetamide::CHEMBL476136 Serine/threonine-protein kinase PLK1 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263444&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579007 104111796 CHEMBL476136 ZINC13981947 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430245 CCOC(=O)C(\C#N)=c1/s\c(=C\Nc2ccccc2F)c(=O)n1CC InChI=1S/C17H16FN3O3S/c1-3-21-15(22)14(10-20-13-8-6-5-7-12(13)18)25-16(21)11(9-19)17(23)24-4-2/h5-8,10,20H,3-4H2,1-2H3/b14-10+,16-11- IAQKTFXXNGYFFJ-DECHVDIESA-N 50263445 CHEMBL476137::ethyl 2-cyano-2-(3-ethyl-5-((2-fluorophenylamino)methylene)-4-oxothiazolidin-2-ylidene)acetate Serine/threonine-protein kinase PLK1 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263445&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579008 104111797 CHEMBL476137 ZINC38358020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430246 CCn1c(=O)\c(=C/Nc2ccccc2)s\c1=C(\C#N)C(=O)N1CCCC1 InChI=1S/C19H20N4O2S/c1-2-23-18(25)16(13-21-14-8-4-3-5-9-14)26-19(23)15(12-20)17(24)22-10-6-7-11-22/h3-5,8-9,13,21H,2,6-7,10-11H2,1H3/b16-13+,19-15- SUQKLEASBBZJQK-MDANOKLJSA-N 50263446 2-(3-ethyl-4-oxo-5-((phenylamino)methylene)thiazolidin-2-ylidene)-3-oxo-3-(pyrrolidin-1-yl)propanenitrile::CHEMBL476138 Serine/threonine-protein kinase PLK1 Homo sapiens 270 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263446&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579009 104111798 CHEMBL476138 ZINC13981956 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430247 CN(C(C)=O)c1cccc(Nc2nc(NCCc3cccs3)ncc2-c2nnn[nH]2)c1 InChI=1S/C20H21N9OS/c1-13(30)29(2)15-6-3-5-14(11-15)23-18-17(19-25-27-28-26-19)12-22-20(24-18)21-9-8-16-7-4-10-31-16/h3-7,10-12H,8-9H2,1-2H3,(H2,21,22,23,24)(H,25,26,27,28) GZIRZWYLRVDXGD-UHFFFAOYSA-N 50263489 CHEMBL478654::N-(3-(5-(2H-tetrazol-5-yl)-2-(2-(thiophen-2-yl)ethylamino)pyrimidin-4-ylamino)phenyl)-N-methylacetamide Serine/threonine-protein kinase PLK1 Homo sapiens 330 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263489&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579061 104111818 CHEMBL478654 ZINC40918841 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430248 CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1cccs1 InChI=1S/C23H26N6O2S/c1-27-8-10-28(11-9-27)17-6-4-16(5-7-17)23(31)24-22-19-14-29(15-20(19)25-26-22)21(30)13-18-3-2-12-32-18/h2-7,12H,8-11,13-15H2,1H3,(H2,24,25,26,31) BMCKWRUTJXVUFF-UHFFFAOYSA-N 12107 1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 15::4-(4-Methyl-piperazin-1-yl)-N-[5-(2-thiophen-2-yl-acetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-benzamide::4-(4-methylpiperazin-1-yl)-N-{5-[2-(thiophen-2-yl)acetyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}benzamide::5-Amido-pyrrolopyrazole 3::CHEMBL516110 Serine/threonine-protein kinase PLK1 Homo sapiens 530 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12107&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11751305 46512611 CHEMBL516110 ZINC13643145 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430249 CCCN(CC1CC1)c1nc(NC(C)c2ccccc2)ncc1C#N InChI=1S/C20H25N5/c1-3-11-25(14-16-9-10-16)19-18(12-21)13-22-20(24-19)23-15(2)17-7-5-4-6-8-17/h4-8,13,15-16H,3,9-11,14H2,1-2H3,(H,22,23,24) MQCGWEBGUUSVOF-UHFFFAOYSA-N 50263490 4-((cyclopropylmethyl)(propyl)amino)-2-(1-phenylethylamino)pyrimidine-5-carbonitrile::CHEMBL477393 Serine/threonine-protein kinase PLK1 Homo sapiens 550 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263490&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579062 104111819 CHEMBL477393 ZINC40917750 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430250 COc1cccc(Nc2nc(NC(C)c3ccccc3)ncc2C#N)c1 InChI=1S/C20H19N5O/c1-14(15-7-4-3-5-8-15)23-20-22-13-16(12-21)19(25-20)24-17-9-6-10-18(11-17)26-2/h3-11,13-14H,1-2H3,(H2,22,23,24,25) AWFBHHWLICFNAK-UHFFFAOYSA-N 50263491 4-(3-methoxyphenylamino)-2-(1-phenylethylamino)pyrimidine-5-carbonitrile::CHEMBL477604 Serine/threonine-protein kinase PLK1 Homo sapiens 580 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263491&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9906179 104111820 CHEMBL477604 ZINC40916399 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430251 CC(Nc1ncc(C#N)c(n1)N1CCc2ccccc2C1)c1ccccc1 InChI=1S/C22H21N5/c1-16(17-7-3-2-4-8-17)25-22-24-14-20(13-23)21(26-22)27-12-11-18-9-5-6-10-19(18)15-27/h2-10,14,16H,11-12,15H2,1H3,(H,24,25,26) UJKARJPMQQXALD-UHFFFAOYSA-N 50263492 4-(3,4-dihydroisoquinolin-2(1H)-yl)-2-(1-phenylethylamino)pyrimidine-5-carbonitrile::CHEMBL477605 Serine/threonine-protein kinase PLK1 Homo sapiens 750 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263492&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579063 104111821 CHEMBL477605 ZINC40404443 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430252 CC(C)(C)c1ccc(Nc2nc(NCc3cccnc3)ncc2-c2nnn[nH]2)cc1 InChI=1S/C21H23N9/c1-21(2,3)15-6-8-16(9-7-15)25-18-17(19-27-29-30-28-19)13-24-20(26-18)23-12-14-5-4-10-22-11-14/h4-11,13H,12H2,1-3H3,(H2,23,24,25,26)(H,27,28,29,30) SDLDBOWHHGVIPE-UHFFFAOYSA-N 50263530 CHEMBL476145::N4-(4-tert-butylphenyl)-N2-(pyridin-3-ylmethyl)-5-(2H-tetrazol-5-yl)pyrimidine-2,4-diamine Serine/threonine-protein kinase PLK1 Homo sapiens 960 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263530&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579103 104111839 CHEMBL476145 ZINC40918434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430253 C(Cc1cccs1)Nc1ncc(-c2nnn[nH]2)c(Nc2ccc3OCCOc3c2)n1 InChI=1S/C19H18N8O2S/c1-2-13(30-9-1)5-6-20-19-21-11-14(18-24-26-27-25-18)17(23-19)22-12-3-4-15-16(10-12)29-8-7-28-15/h1-4,9-11H,5-8H2,(H2,20,21,22,23)(H,24,25,26,27) BBTKUDMPZSPCOV-UHFFFAOYSA-N 50263531 CHEMBL476146::N4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2H-tetrazol-5-yl)-N2-(2-(thiophen-2-yl)ethyl)pyrimidine-2,4-diamine Serine/threonine-protein kinase PLK1 Homo sapiens 1040 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263531&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579104 104111840 CHEMBL476146 ZINC40405449 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430254 [O-][N+](=O)c1ccc(Nc2nccc(n2)-c2cccc(c2)[N+]([O-])=O)cc1 InChI=1S/C16H11N5O4/c22-20(23)13-6-4-12(5-7-13)18-16-17-9-8-15(19-16)11-2-1-3-14(10-11)21(24)25/h1-10H,(H,17,18,19) FDVRZMRAZJTLEK-UHFFFAOYSA-N 50263532 4-(3-nitrophenyl)-N-(4-nitrophenyl)pyrimidin-2-amine::CHEMBL518265 Serine/threonine-protein kinase PLK1 Homo sapiens 6500 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263532&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11522898 104111841 CHEMBL518265 ZINC40918435 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430255 CC(=O)Nc1cccc(c1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C18H16N4O2/c1-12(23)20-15-4-2-3-13(11-15)17-9-10-19-18(22-17)21-14-5-7-16(24)8-6-14/h2-11,24H,1H3,(H,20,23)(H,19,21,22) VQMXEYMHISITRF-UHFFFAOYSA-N 50263533 CHEMBL455343::N-(3-(2-(4-hydroxyphenylamino)pyrimidin-4-yl)phenyl)acetamide Serine/threonine-protein kinase PLK1 Homo sapiens 6900 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11587793 104111842 CHEMBL455343 ZINC35875815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430256 Clc1ccc(Nc2nccc(n2)-c2cccc(Cl)c2)cc1 InChI=1S/C16H11Cl2N3/c17-12-4-6-14(7-5-12)20-16-19-9-8-15(21-16)11-2-1-3-13(18)10-11/h1-10H,(H,19,20,21) DMPLZTRKPZGODD-UHFFFAOYSA-N 50263534 4-(3-chlorophenyl)-N-(4-chlorophenyl)pyrimidin-2-amine::CHEMBL504667 Serine/threonine-protein kinase PLK1 Homo sapiens 8700 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11580497 104111843 CHEMBL504667 ZINC35857162 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430257 N[C@H](COc1cncc(c1)-c1cc2ccncc2s1)Cc1c[nH]c2ccccc12 InChI=1S/C23H20N4OS/c24-18(7-16-11-27-21-4-2-1-3-20(16)21)14-28-19-8-17(10-26-12-19)22-9-15-5-6-25-13-23(15)29-22/h1-6,8-13,18,27H,7,14,24H2/t18-/m0/s1 GWJHMRBQEUHFOC-SFHVURJKSA-N 16919 3-[(2S)-2-amino-3-[(5-{thieno[2,3-c]pyridin-2-yl}pyridin-3-yl)oxy]propyl]-1H-indole::Biochemistry 469551 Compound 12::CHEMBL516429::thieno[2,3-c]pyridine, 9a Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10216158 46517151 CHEMBL516429 ZINC14962351 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430258 Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H YXOLAZRVSSWPPT-UHFFFAOYSA-N 26658 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one::2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one::CHEMBL28626::MLS000069618::Morin (19)::Morin (5)::Morin (Mor)::SMR000058259::cid_5281670::morin Serine/threonine-protein kinase PLK1 Homo sapiens 12600 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26658&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search MRI 5AUY,8A0P,7E4B,6AE3,6TT8 5281670 57298370 75092 CHEMBL28626 411 C10105 ZINC03881558 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430259 CCCOC(=O)C(\C#N)=c1/s\c(=C\Nc2ccc(O)cc2)c(=O)n1CC InChI=1S/C18H19N3O4S/c1-3-9-25-18(24)14(10-19)17-21(4-2)16(23)15(26-17)11-20-12-5-7-13(22)8-6-12/h5-8,11,20,22H,3-4,9H2,1-2H3/b15-11+,17-14- CBSGBZLWOKWSDJ-IQOWBAITSA-N 50263587 CHEMBL477615::propyl 2-cyano-2-(3-ethyl-5-((4-hydroxyphenylamino)methylene)-4-oxothiazolidin-2-ylidene)acetate Serine/threonine-protein kinase PLK1 Homo sapiens 36 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263587&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579148 104111869 CHEMBL477615 ZINC40917531 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430260 CCOC(=O)C(\C#N)=c1/s\c(=C\Nc2ccc(NC(=O)NCCN3CCCC3)cc2)c(=O)n1CC InChI=1S/C24H30N6O4S/c1-3-30-21(31)20(35-22(30)19(15-25)23(32)34-4-2)16-27-17-7-9-18(10-8-17)28-24(33)26-11-14-29-12-5-6-13-29/h7-10,16,27H,3-6,11-14H2,1-2H3,(H2,26,28,33)/b20-16+,22-19- BIHLOOSBOOUCJL-VHDRYYFZSA-N 50263588 CHEMBL477616::ethyl 2-cyano-2-(3-ethyl-4-oxo-5-((4-(3-(2-(pyrrolidin-1-yl)ethyl)ureido)phenylamino)methylene)thiazolidin-2-ylidene)acetate Serine/threonine-protein kinase PLK1 Homo sapiens 37 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263588&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579149 104111870 CHEMBL477616 ZINC13981951 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430261 CCOC(=O)C(\C#N)=c1/s\c(=C\Nc2cccc(C)c2)c(=O)n1CC InChI=1S/C18H19N3O3S/c1-4-21-16(22)15(11-20-13-8-6-7-12(3)9-13)25-17(21)14(10-19)18(23)24-5-2/h6-9,11,20H,4-5H2,1-3H3/b15-11+,17-14- IDYLTQUWXPGKQC-IQOWBAITSA-N 50263589 CHEMBL503480::ethyl 2-(5-((m-toluidino)methylene)-3-ethyl-4-oxothiazolidin-2-ylidene)-2-cyanoacetate Serine/threonine-protein kinase PLK1 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263589&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579150 104111871 CHEMBL503480 ZINC36423698 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50422608 CN(C)CCCNC(=O)c1csc2nc(cn12)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1 InChI=1S/C25H31N7O3S/c1-25(2,3)20-13-21(30-35-20)29-23(34)27-17-9-7-16(8-10-17)18-14-32-19(15-36-24(32)28-18)22(33)26-11-6-12-31(4)5/h7-10,13-15H,6,11-12H2,1-5H3,(H,26,33)(H2,27,29,30,34) VBYMFAOTZHNONG-UHFFFAOYSA-N 50123803 CHEMBL3623375 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2015.08.068 10.7270/Q24X59MV 26342867 Lin, XD; Yang, HW; Ma, S; Li, WW; Zhang, CH; Wang, WJ; Xiang, R; Li, LL; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50123803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50123803&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 122192466 104016215 CHEMBL3623375 ZINC13589966 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430262 CCOC(=O)C(C#N)=c1sc(=CNc2ccc(cc2)C(C)=O)c(=O)n1CC InChI=1S/C19H19N3O4S/c1-4-22-17(24)16(27-18(22)15(10-20)19(25)26-5-2)11-21-14-8-6-13(7-9-14)12(3)23/h6-9,11,21H,4-5H2,1-3H3 RMIKFPYOGZIARZ-UHFFFAOYSA-N 50263643 CHEMBL476575::ethyl 2-(5-((4-acetylphenylamino)methylene)-3-ethyl-4-oxothiazolidin-2-ylidene)-2-cyanoacetate Serine/threonine-protein kinase PLK1 Homo sapiens 81 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263643&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579203 104111900 CHEMBL476575 ZINC13981949 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430263 CCn1c(=O)\c(=C/Nc2cccc(NC(=O)C(C)(C)C)c2)s\c1=C(\C#N)C(=O)NC1(CO)CCCC1 InChI=1S/C26H33N5O4S/c1-5-31-22(34)20(15-28-17-9-8-10-18(13-17)29-24(35)25(2,3)4)36-23(31)19(14-27)21(33)30-26(16-32)11-6-7-12-26/h8-10,13,15,28,32H,5-7,11-12,16H2,1-4H3,(H,29,35)(H,30,33)/b20-15+,23-19- KHDHLGCXXGSPFS-DXPSTKMYSA-N 50263644 CHEMBL476782::N-(3-((2-(1-cyano-2-(1-(hydroxymethyl)cyclopentylamino)-2-oxoethylidene)-3-ethyl-4-oxothiazolidin-5-ylidene)methylamino)phenyl)pivalamide Serine/threonine-protein kinase PLK1 Homo sapiens 190 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263644&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579204 104111901 CHEMBL476782 ZINC13981958 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430264 CCNC(=O)C(\C#N)=c1/s\c(=C\Nc2cccc(c2)C(=O)NCCCN2CCCC2)c(=O)n1CC InChI=1S/C25H32N6O3S/c1-3-27-23(33)20(16-26)25-31(4-2)24(34)21(35-25)17-29-19-10-7-9-18(15-19)22(32)28-11-8-14-30-12-5-6-13-30/h7,9-10,15,17,29H,3-6,8,11-14H2,1-2H3,(H,27,33)(H,28,32)/b21-17+,25-20- DYCWWYFWOMGIRJ-UGFCBVJVSA-N 50263645 3-((2-(1-cyano-2-(ethylamino)-2-oxoethylidene)-3-ethyl-4-oxothiazolidin-5-ylidene)methylamino)-N-(3-(pyrrolidin-1-yl)propyl)benzamide::CHEMBL475946 Serine/threonine-protein kinase PLK1 Homo sapiens 345 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263645&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579205 104111902 CHEMBL475946 ZINC40916591 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430265 FC(F)(F)c1ccc(Nc2nc(NCc3cccnc3)ncc2-c2nnn[nH]2)cc1 InChI=1S/C18H14F3N9/c19-18(20,21)12-3-5-13(6-4-12)25-15-14(16-27-29-30-28-16)10-24-17(26-15)23-9-11-2-1-7-22-8-11/h1-8,10H,9H2,(H2,23,24,25,26)(H,27,28,29,30) REBNCEBGAGULRY-UHFFFAOYSA-N 50263646 CHEMBL475947::N2-(pyridin-3-ylmethyl)-5-(2H-tetrazol-5-yl)-N4-(4-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine Serine/threonine-protein kinase PLK1 Homo sapiens 490 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263646&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579206 104111903 CHEMBL475947 ZINC40405328 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430266 CCOC(=O)C(\C#N)=c1/s\c(=C\Nc2ccc(NC(=O)COC)cc2)c(=O)n1CC InChI=1S/C20H22N4O5S/c1-4-24-18(26)16(30-19(24)15(10-21)20(27)29-5-2)11-22-13-6-8-14(9-7-13)23-17(25)12-28-3/h6-9,11,22H,4-5,12H2,1-3H3,(H,23,25)/b16-11+,19-15- NIYMJRDDNSYXBD-SRDSUALGSA-N 50263693 CHEMBL516582::ethyl 2-cyano-2-(3-ethyl-5-((4-(2-methoxyacetamido)phenylamino)methylene)-4-oxothiazolidin-2-ylidene)acetate Serine/threonine-protein kinase PLK1 Homo sapiens 500 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263693&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579245 104111936 CHEMBL516582 ZINC40918845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430267 CC(Nc1ncc(C#N)c(OCC2CCCCO2)n1)c1ccccc1 InChI=1S/C19H22N4O2/c1-14(15-7-3-2-4-8-15)22-19-21-12-16(11-20)18(23-19)25-13-17-9-5-6-10-24-17/h2-4,7-8,12,14,17H,5-6,9-10,13H2,1H3,(H,21,22,23) LUTZKGPIPXGJOV-UHFFFAOYSA-N 50263694 2-(1-phenylethylamino)-4-((tetrahydro-2H-pyran-2-yl)methoxy)pyrimidine-5-carbonitrile::CHEMBL478892 Serine/threonine-protein kinase PLK1 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263694&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579246 104111937 CHEMBL478892 ZINC40410804 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430268 CCCN(CC1CC1)c1nc(NCc2ccc3OCOc3c2)ncc1C#N InChI=1S/C20H23N5O2/c1-2-7-25(12-14-3-4-14)19-16(9-21)11-23-20(24-19)22-10-15-5-6-17-18(8-15)27-13-26-17/h5-6,8,11,14H,2-4,7,10,12-13H2,1H3,(H,22,23,24) YKKZIVOCUDNMCA-UHFFFAOYSA-N 50263695 2-(benzo[d][1,3]dioxol-5-ylmethylamino)-4-((cyclopropylmethyl)(propyl)amino)pyrimidine-5-carbonitrile::CHEMBL476123 Serine/threonine-protein kinase PLK1 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263695&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44579247 104111938 CHEMBL476123 ZINC40917398 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430269 Oc1ccc(\C=C2\C(=O)C(C3=C4C(=Nc5ccccc45)\C(=C/c4ccc(O)cc4)C3=O)=C3C2=Nc2ccccc32)cc1 InChI=1S/C36H20N2O4/c39-21-13-9-19(10-14-21)17-25-33-29(23-5-1-3-7-27(23)37-33)31(35(25)41)32-30-24-6-2-4-8-28(24)38-34(30)26(36(32)42)18-20-11-15-22(40)16-12-20/h1-18,39-40H/b25-17+,26-18+ CGZKSPLDUIRCIO-RPCRKUJJSA-N 50263696 3-(4-hydroxybenzylidene)-1-(3-(4-hydroxybenzylidene)-2-oxo-2,3-dihydrocyclopenta[b]indol-1-yl)cyclopenta[b]indol-2(3H)-one::CHEMBL507146 Serine/threonine-protein kinase PLK1 Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263696&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5486761 104111939 CHEMBL507146 ZINC35212830 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430270 NC(=O)c1sc2c(cc(cc2[n+]1[O-])C(F)(F)F)[N+]([O-])=O InChI=1S/C9H4F3N3O4S/c10-9(11,12)3-1-4-6(5(2-3)15(18)19)20-8(7(13)16)14(4)17/h1-2H,(H2,13,16) FHFLXKUKCSDMLD-UHFFFAOYSA-N 50263697 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide::CHEMBL476124::cyclapolin 9 Serine/threonine-protein kinase PLK1 Homo sapiens 2400 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263697&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2779952 104111940 CHEMBL476124 ZINC02577648 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430271 Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C15H14N4OS/c1-9-14(21-10(2)17-9)13-7-8-16-15(19-13)18-11-3-5-12(20)6-4-11/h3-8,20H,1-2H3,(H,16,18,19) GDZTURHUKDAJGD-UHFFFAOYSA-N 8053 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24::4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol::4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]phenol, 5::4-{[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]amino}phenol::CHEMBL442957 Serine/threonine-protein kinase PLK1 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6539291 11108807 CHEMBL442957 ZINC13559869 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430272 Nc1cccc(c1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C16H14N4O/c17-12-3-1-2-11(10-12)15-8-9-18-16(20-15)19-13-4-6-14(21)7-5-13/h1-10,21H,17H2,(H,18,19,20) XSOKAUVTVVRPLR-UHFFFAOYSA-N 50263698 4-[4-(3-Amino-phenyl)-pyrimidin-2-ylamino]-phenol::CHEMBL476125 Serine/threonine-protein kinase PLK1 Homo sapiens 7800 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263698&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11572678 104111941 CHEMBL476125 ZINC35838054 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430273 CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C15H15N5OS/c1-9-13(22-15(16-2)18-9)12-7-8-17-14(20-12)19-10-3-5-11(21)6-4-10/h3-8,21H,1-2H3,(H,16,18)(H,17,19,20) OTMLAWRVLMYMDF-UHFFFAOYSA-N 8054 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 25::4-({4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl}amino)phenol::4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2-ylamino]phenol::4-[4-(4-Methyl-2-methylaminothiazol-5-yl)pyrimidin-2-ylamino]phenol, 6::CHEMBL47590 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8054&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search CK6 1PXN 447960 11108808 CHEMBL47590 DB04407 ZINC02047390 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430274 NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O InChI=1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14) FKRBAXZAJBBIAJ-UHFFFAOYSA-N 50263741 5-Cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide::CHEMBL492008 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263741&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9548007 104111966 CHEMBL492008 ZINC35212821 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430275 CNc1cccc(c1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C17H16N4O/c1-18-14-4-2-3-12(11-14)16-9-10-19-17(21-16)20-13-5-7-15(22)8-6-13/h2-11,18,22H,1H3,(H,19,20,21) VWJOTIHLTSPRPF-UHFFFAOYSA-N 50263742 4-(4-(3-(methylamino)phenyl)pyrimidin-2-ylamino)phenol::CHEMBL526709 Serine/threonine-protein kinase PLK1 Homo sapiens 13700 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263742&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11500264 104111967 CHEMBL526709 ZINC40979363 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430276 [O-][N+](=O)c1cc(cc2[n+]([O-])c(sc12)C#N)C(F)(F)F InChI=1S/C9H2F3N3O3S/c10-9(11,12)4-1-5-8(6(2-4)15(17)18)19-7(3-13)14(5)16/h1-2H QEADTFDNZKZTBX-UHFFFAOYSA-N 50263743 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carbonitrile::CHEMBL450653 Serine/threonine-protein kinase PLK1 Homo sapiens 21000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263743&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10085550 104111968 CHEMBL450653 ZINC40835975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430277 [O-]n1c2cc(cc([N+]([O-])=O)c2sc1=[OH+])C(F)(F)F InChI=1S/C8H2F3N2O4S/c9-8(10,11)3-1-4-6(5(2-3)13(16)17)18-7(14)12(4)15/h1-2H/q-1/p+1 PZLPXLJLNMBFLO-UHFFFAOYSA-O 50263744 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazol-2-ol::CHEMBL492009 Serine/threonine-protein kinase PLK1 Homo sapiens 39000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263744&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10401406 104111969 CHEMBL492009 ZINC38779095 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430278 [O-][N+](=O)c1cc(cc2[n+]([O-])c(sc12)C(=O)N1CCCC1)C(F)(F)F InChI=1S/C13H10F3N3O4S/c14-13(15,16)7-5-8-10(9(6-7)19(22)23)24-12(18(8)21)11(20)17-3-1-2-4-17/h5-6H,1-4H2 RYVNGNMKKJXKQG-UHFFFAOYSA-N 50263745 (7-Nitro-3-oxy-5-trifluoromethyl-benzothiazol-2-yl)-pyrrolidin-1-yl-methanone::CHEMBL523487 Serine/threonine-protein kinase PLK1 Homo sapiens 56000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263745&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2779943 104111970 CHEMBL523487 ZINC02557781 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50430279 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Serine/threonine-protein kinase PLK1 Homo sapiens 64000 ChEMBL 10.1016/j.bmcl.2008.08.033 10.7270/Q26973DV 18762425 Wang, HY; Cao, ZX; Li, LL; Jiang, PD; Zhao, YL; Luo, SD; Yang, L; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search QUE 3BPT,2HCK,3LJ0,4LMU,5FLI,5FLJ,3CF8,4DFU,4MRA,4WNJ,2O3P,2MS6,5AUW,3BXX,6M89,3LM5,1GP6,6AWS,6QCN,6QCD,7VUM,6B1D,2N6C,1E8W,2C9Z,5XG4,5A4V,2UXH,1H1I,2JJ2,6TTA,6IJD,3NVY 5280343 11108251 16243 CHEMBL50 DB04216 5346 C00389 ZINC03869685 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436325 Cc1nc(-c2ccccc2)n2nc(NCc3ccccc3)ncc12 InChI=1S/C19H17N5/c1-14-17-13-21-19(20-12-15-8-4-2-5-9-15)23-24(17)18(22-14)16-10-6-3-7-11-16/h2-11,13H,12H2,1H3,(H,20,23) PJMNNEYQWXCLAY-UHFFFAOYSA-N 50275589 CHEMBL519225::N-benzyl-5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine Serine/threonine-protein kinase PLK1 Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275589&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44589693 104119015 CHEMBL519225 ZINC40423673 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436326 Cc1nc(-c2ccccc2)n2nc(N)ncc12 InChI=1S/C12H11N5/c1-8-10-7-14-12(13)16-17(10)11(15-8)9-5-3-2-4-6-9/h2-7H,1H3,(H2,13,16) FDTKEAYRLULHPR-UHFFFAOYSA-N 50275590 5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL519224 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275590&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44589694 104119016 CHEMBL519224 ZINC40423672 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436327 Cc1nc(-c2ccccc2)n2nc(NCCc3ccncc3)ncc12 InChI=1S/C19H18N6/c1-14-17-13-22-19(21-12-9-15-7-10-20-11-8-15)24-25(17)18(23-14)16-5-3-2-4-6-16/h2-8,10-11,13H,9,12H2,1H3,(H,21,24) HWPQPWKOTZIMLC-UHFFFAOYSA-N 50275591 5-methyl-7-phenyl-N-(2-(pyridin-4-yl)ethyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL486123 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275591&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44589695 104119017 CHEMBL486123 ZINC45484940 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436328 Cc1nc(-c2ccccc2)n2nc(NCCCN3CCOCC3)ncc12 InChI=1S/C19H24N6O/c1-15-17-14-21-19(20-8-5-9-24-10-12-26-13-11-24)23-25(17)18(22-15)16-6-3-2-4-7-16/h2-4,6-7,14H,5,8-13H2,1H3,(H,20,23) IFOFHKDVJCOAMH-UHFFFAOYSA-N 50275592 5-methyl-N-(3-morpholinopropyl)-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL486124 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275592&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44589696 104119018 CHEMBL486124 ZINC45484943 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436329 Cc1nc(-c2ccccc2)n2nc(NC3CCCCC3)ncc12 InChI=1S/C18H21N5/c1-13-16-12-19-18(21-15-10-6-3-7-11-15)22-23(16)17(20-13)14-8-4-2-5-9-14/h2,4-5,8-9,12,15H,3,6-7,10-11H2,1H3,(H,21,22) MGRDVSFDVBSTNK-UHFFFAOYSA-N 50275624 CHEMBL487776::N-cyclohexyl-5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275624&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11185889 104119041 CHEMBL487776 ZINC38341805 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436330 Cc1nc(-c2ccccc2)n2nc(Nc3ccccc3)ncc12 InChI=1S/C18H15N5/c1-13-16-12-19-18(21-15-10-6-3-7-11-15)22-23(16)17(20-13)14-8-4-2-5-9-14/h2-12H,1H3,(H,21,22) VMVVGNPEKKNKGG-UHFFFAOYSA-N 50275625 5-methyl-N,7-diphenylimidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL487976 Serine/threonine-protein kinase PLK1 Homo sapiens 1200 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275625&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11438062 104119042 CHEMBL487976 ZINC45497622 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436331 COc1cccc(Nc2ncc3c(C)nc(-c4ccccc4)n3n2)c1 InChI=1S/C19H17N5O/c1-13-17-12-20-19(22-15-9-6-10-16(11-15)25-2)23-24(17)18(21-13)14-7-4-3-5-8-14/h3-12H,1-2H3,(H,22,23) JDTGPBOAWBXCCA-UHFFFAOYSA-N 50275626 CHEMBL487977::N-(3-methoxyphenyl)-5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine Serine/threonine-protein kinase PLK1 Homo sapiens 300 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275626&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11174936 104119043 CHEMBL487977 ZINC38329941 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436332 COc1ccc(Nc2ncc3c(C)nc(-c4ccccc4)n3n2)cc1 InChI=1S/C19H17N5O/c1-13-17-12-20-19(22-15-8-10-16(25-2)11-9-15)23-24(17)18(21-13)14-6-4-3-5-7-14/h3-12H,1-2H3,(H,22,23) OOAGGWFWEDEIEG-UHFFFAOYSA-N 50275627 CHEMBL519257::N-(4-methoxyphenyl)-5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine Serine/threonine-protein kinase PLK1 Homo sapiens 680 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275627&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44589729 104119044 CHEMBL519257 ZINC40423647 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436333 CN(C)CCOc1ccc(Nc2ncc3c(C)nc(-c4ccccc4)n3n2)cc1 InChI=1S/C22H24N6O/c1-16-20-15-23-22(26-28(20)21(24-16)17-7-5-4-6-8-17)25-18-9-11-19(12-10-18)29-14-13-27(2)3/h4-12,15H,13-14H2,1-3H3,(H,25,26) NJYSBNVFMMHDGP-UHFFFAOYSA-N 50275628 CHEMBL520692::N-(4-(2-(dimethylamino)ethoxy)phenyl)-5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine Serine/threonine-protein kinase PLK1 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275628&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11372661 104119045 CHEMBL520692 ZINC42887894 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436334 Cc1nc(-c2ccccc2)n2nc(Nc3cccc(c3)C(F)(F)F)ncc12 InChI=1S/C19H14F3N5/c1-12-16-11-23-18(25-15-9-5-8-14(10-15)19(20,21)22)26-27(16)17(24-12)13-6-3-2-4-7-13/h2-11H,1H3,(H,25,26) IDFIYKSUKKYWOX-UHFFFAOYSA-N 50275661 5-methyl-7-phenyl-N-(3-(trifluoromethyl)phenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL486346 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275661&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11187801 104119068 CHEMBL486346 ZINC38345507 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436335 Cc1nc(-c2ccccc2)n2nc(Nc3ccc(cc3)[N+]([O-])=O)ncc12 InChI=1S/C18H14N6O2/c1-12-16-11-19-18(21-14-7-9-15(10-8-14)24(25)26)22-23(16)17(20-12)13-5-3-2-4-6-13/h2-11H,1H3,(H,21,22) SHGIFHQYGDEMJX-UHFFFAOYSA-N 50275662 5-methyl-N-(4-nitrophenyl)-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL486550 Serine/threonine-protein kinase PLK1 Homo sapiens 2810 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275662&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11244902 104119069 CHEMBL486550 ZINC45484460 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436336 Cc1nc(-c2ccccc2)n2nc(Nc3ccc(cc3)S(N)(=O)=O)ncc12 InChI=1S/C18H16N6O2S/c1-12-16-11-20-18(22-14-7-9-15(10-8-14)27(19,25)26)23-24(16)17(21-12)13-5-3-2-4-6-13/h2-11H,1H3,(H,22,23)(H2,19,25,26) OSGIHOCRIKNRJD-UHFFFAOYSA-N 50275663 4-(5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-ylamino)benzenesulfonamide::CHEMBL486551 Serine/threonine-protein kinase PLK1 Homo sapiens 2740 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275663&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11211191 104119070 CHEMBL486551 ZINC45484792 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436337 COc1ccc(Nc2ncc3c(C)nc(-c4ccccc4)n3n2)cc1OC InChI=1S/C20H19N5O2/c1-13-16-12-21-20(23-15-9-10-17(26-2)18(11-15)27-3)24-25(16)19(22-13)14-7-5-4-6-8-14/h4-12H,1-3H3,(H,23,24) NIAPOVDFZNARJZ-UHFFFAOYSA-N 50275664 CHEMBL521204::N-(3,4-dimethoxyphenyl)-5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-amine Serine/threonine-protein kinase PLK1 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275664&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11405758 104119071 CHEMBL521204 ZINC42878485 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436338 COc1cc(Nc2ncc3c(C)nc(-c4ccccc4)n3n2)cc(OC)c1OC InChI=1S/C21H21N5O3/c1-13-16-12-22-21(25-26(16)20(23-13)14-8-6-5-7-9-14)24-15-10-17(27-2)19(29-4)18(11-15)28-3/h5-12H,1-4H3,(H,24,25) HOOQLZPFGONGJY-UHFFFAOYSA-N 50275665 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine::CHEMBL519715 Serine/threonine-protein kinase PLK1 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275665&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search T2A 3EOC 9886746 104119072 CHEMBL519715 ZINC06716390 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436339 COc1ccccc1-c1nc(C)c2cnc(Nc3cc(OC)c(OC)c(OC)c3)nn12 InChI=1S/C22H23N5O4/c1-13-16-12-23-22(25-14-10-18(29-3)20(31-5)19(11-14)30-4)26-27(16)21(24-13)15-8-6-7-9-17(15)28-2/h6-12H,1-5H3,(H,25,26) ZHKBCNKXWIHWMO-UHFFFAOYSA-N 50275699 7-(2-methoxyphenyl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL486966 Serine/threonine-protein kinase PLK1 Homo sapiens 5660 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275699&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11304724 104119097 CHEMBL486966 ZINC45497553 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436340 COc1cc(Nc2ncc3c(C)nc(-c4ccccc4[N+]([O-])=O)n3n2)cc(OC)c1OC InChI=1S/C21H20N6O5/c1-12-16-11-22-21(24-13-9-17(30-2)19(32-4)18(10-13)31-3)25-26(16)20(23-12)14-7-5-6-8-15(14)27(28)29/h5-11H,1-4H3,(H,24,25) AHLIMUMCWAPZNP-UHFFFAOYSA-N 50275700 5-methyl-7-(2-nitrophenyl)-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL487574 Serine/threonine-protein kinase PLK1 Homo sapiens 1980 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275700&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11293491 104119098 CHEMBL487574 ZINC45497966 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436341 COc1cc(Nc2ncc3c(C)nc(-c4ccccc4Br)n3n2)cc(OC)c1OC InChI=1S/C21H20BrN5O3/c1-12-16-11-23-21(25-13-9-17(28-2)19(30-4)18(10-13)29-3)26-27(16)20(24-12)14-7-5-6-8-15(14)22/h5-11H,1-4H3,(H,25,26) UNCFEUIRUGJPNL-UHFFFAOYSA-N 50275701 7-(2-bromophenyl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL518916 Serine/threonine-protein kinase PLK1 Homo sapiens 2670 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275701&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11294348 104119099 CHEMBL518916 ZINC40423068 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436342 COc1cc(Nc2ncc3c(C)nc(-c4cccc(Br)c4)n3n2)cc(OC)c1OC InChI=1S/C21H20BrN5O3/c1-12-16-11-23-21(25-15-9-17(28-2)19(30-4)18(10-15)29-3)26-27(16)20(24-12)13-6-5-7-14(22)8-13/h5-11H,1-4H3,(H,25,26) OPHVXMFZPABPCU-UHFFFAOYSA-N 50275702 7-(3-bromophenyl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL519375 Serine/threonine-protein kinase PLK1 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275702&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11213555 104119100 CHEMBL519375 ZINC06716392 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436343 COc1cc(Nc2ncc3c(C)nc(-c4cccc(c4)C(F)(F)F)n3n2)cc(OC)c1OC InChI=1S/C22H20F3N5O3/c1-12-16-11-26-21(28-15-9-17(31-2)19(33-4)18(10-15)32-3)29-30(16)20(27-12)13-6-5-7-14(8-13)22(23,24)25/h5-11H,1-4H3,(H,28,29) FGUYNCHKIOFPMS-UHFFFAOYSA-N 50275752 5-methyl-7-(3-(trifluoromethyl)phenyl)-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL520037 Serine/threonine-protein kinase PLK1 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275752&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11328632 104119145 CHEMBL520037 ZINC06716391 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436344 COc1cc(Nc2ncc3c(C)nc(-c4ccc(cc4)C(F)(F)F)n3n2)cc(OC)c1OC InChI=1S/C22H20F3N5O3/c1-12-16-11-26-21(28-15-9-17(31-2)19(33-4)18(10-15)32-3)29-30(16)20(27-12)13-5-7-14(8-6-13)22(23,24)25/h5-11H,1-4H3,(H,28,29) QHXLBAFASGNOGD-UHFFFAOYSA-N 50275753 5-methyl-7-(4-(trifluoromethyl)phenyl)-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL486367 Serine/threonine-protein kinase PLK1 Homo sapiens 1060 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275753&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11465304 104119146 CHEMBL486367 ZINC45484139 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436345 COc1cc(Nc2ncc3c(C)nc(-c4cccc(c4)C(=O)c4ccccc4)n3n2)cc(OC)c1OC InChI=1S/C28H25N5O4/c1-17-22-16-29-28(31-21-14-23(35-2)26(37-4)24(15-21)36-3)32-33(22)27(30-17)20-12-8-11-19(13-20)25(34)18-9-6-5-7-10-18/h5-16H,1-4H3,(H,31,32) WCWSPMSEMFFBKI-UHFFFAOYSA-N 50275754 (3-(5-methyl-2-(3,4,5-trimethoxyphenylamino)imidazo[1,5-f][1,2,4]triazin-7-yl)phenyl)(phenyl)methanone::CHEMBL519880 Serine/threonine-protein kinase PLK1 Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275754&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11466081 104119147 CHEMBL519880 ZINC40423622 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436346 COc1cc(Nc2ncc3c(C)nc(-c4cccc(Oc5ccccc5)c4)n3n2)cc(OC)c1OC InChI=1S/C27H25N5O4/c1-17-22-16-28-27(30-19-14-23(33-2)25(35-4)24(15-19)34-3)31-32(22)26(29-17)18-9-8-12-21(13-18)36-20-10-6-5-7-11-20/h5-16H,1-4H3,(H,30,31) UYDANWBUSABCEA-UHFFFAOYSA-N 50275755 5-methyl-7-(3-phenoxyphenyl)-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL519881 Serine/threonine-protein kinase PLK1 Homo sapiens 500 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275755&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11155941 104119148 CHEMBL519881 ZINC38310618 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50436347 COc1cc(Nc2ncc3c(C)nc(-c4ccc(F)cc4)n3n2)cc(OC)c1OC InChI=1S/C21H20FN5O3/c1-12-16-11-23-21(25-15-9-17(28-2)19(30-4)18(10-15)29-3)26-27(16)20(24-12)13-5-7-14(22)8-6-13/h5-11H,1-4H3,(H,25,26) IVWUBHFTLDRTBB-UHFFFAOYSA-N 50275806 7-(4-fluorophenyl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL471816 Serine/threonine-protein kinase PLK1 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2008.09.100 10.7270/Q22Z15DQ 18929484 Cheung, M; Kuntz, KW; Pobanz, M; Salovich, JM; Wilson, BJ; Andrews, CW; Shewchuk, LM; Epperly, AH; Hassler, DF; Leesnitzer, MA; Smith, JL; Smith, GK; Lansing, TJ; Mook, RA GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50275806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50275806&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11189040 104119191 CHEMBL471816 ZINC38346622 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50447151 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) ZEHBZHZMQSHZFI-UHFFFAOYSA-N 50135286 CHEMBL3745885 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.045 10.7270/Q24Q7WT8 26762835 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135286&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 67240318 336951802 CHEMBL3745885 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50443096 NC(=N)SCCCn1c(=O)c2c(n3c(cc4ccccc34)c3cccc4ccn2c34)c1=O InChI=1S/C24H19N5O2S/c25-24(26)32-12-4-10-28-22(30)20-21(23(28)31)29-17-8-2-1-5-15(17)13-18(29)16-7-3-6-14-9-11-27(20)19(14)16/h1-3,5-9,11,13H,4,10,12H2,(H3,25,26) RUTCIZOQGCWURK-UHFFFAOYSA-N 50246774 3-(1,3-Dioxo-1,3-dihydro-2H-indolo[1',7':4,5,6]pyrrolo[3',4':2,3][1,4]diazepino[1,7-a]indol-2-yl)propyl Imidothiocarbamate::CHEMBL489083 Serine/threonine-protein kinase PLK1 Homo sapiens 9900 ChEMBL 10.1021/jm800758s 10.7270/Q2HD7VH4 19053831 Danilenko, VN; Simonov, AY; Lakatosh, SA; Kubbutat, MH; Totzke, F; Schachtele, C; Elizarov, SM; Bekker, OB; Printsevskaya, SS; Luzikov, YN; Reznikova, MI; Shtil, AA; Preobrazhenskaya, MN Institute of General Genetics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246774&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25178539 104102124 CHEMBL489083 ZINC40422218 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50447599 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) ZEHBZHZMQSHZFI-UHFFFAOYSA-N 50135286 CHEMBL3745885 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.045 10.7270/Q24Q7WT8 26762835 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135286&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 67240318 336951802 CHEMBL3745885 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50445509 Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1Cl InChI=1S/C20H13Cl2F3N4O2/c21-15-5-4-12(28-18(30)10-2-1-3-11(6-10)20(23,24)25)7-14(15)19(31)29-13-8-16(22)17(26)27-9-13/h1-9H,(H2,26,27)(H,28,30)(H,29,31) CJXUHPRULWSPBE-UHFFFAOYSA-N 50256750 CHEMBL475817::N-(6-amino-5-chloropyridin-3-yl)-2-chloro-5-(3-(trifluoromethyl)benzamido)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2008.10.053 10.7270/Q2222TMP 19097792 Lyne, PD; Aquila, B; Cook, DJ; Dakin, LA; Ezhuthachan, J; Ioannidis, S; Pontz, T; Su, M; Ye, Q; Zheng, X; Block, MH; Cowen, S; Deegan, TL; Lee, JW; Scott, DA; Custeau, D; Drew, L; Poondru, S; Shen, M; Wu, A AstraZeneca R&D Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256750&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11626920 104108115 CHEMBL475817 ZINC35952679 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50459422 O[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C18H18F3N5O/c19-18(20,21)12-3-1-2-11(10-12)17-24-23-16-9-8-15(25-26(16)17)22-13-4-6-14(27)7-5-13/h1-3,8-10,13-14,27H,4-7H2,(H,22,25)/t13-,14- DJIOCMRPQBSLOC-HDJSIYSDSA-N 50258424 CHEMBL494221::trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-ylamino)cyclohexanol Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2009.04.061 10.7270/Q21J99PJ 19414255 Grey, R; Pierce, AC; Bemis, GW; Jacobs, MD; Moody, CS; Jajoo, R; Mohal, N; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258424&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44219633 104109107 CHEMBL494221 ZINC40953870 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50459423 FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCNCC3)nn12 InChI=1S/C17H17F3N6/c18-17(19,20)12-3-1-2-11(10-12)16-24-23-15-5-4-14(25-26(15)16)22-13-6-8-21-9-7-13/h1-5,10,13,21H,6-9H2,(H,22,25) SENFEQVLOFSJFU-UHFFFAOYSA-N 50258287 CHEMBL493169::N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2009.04.061 10.7270/Q21J99PJ 19414255 Grey, R; Pierce, AC; Bemis, GW; Jacobs, MD; Moody, CS; Jajoo, R; Mohal, N; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258287&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44219632 104109030 CHEMBL493169 ZINC40430676 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50499910 COc1ccc(Br)cc1\C=c1/sc2nc(=O)c(C)nn2c1=O InChI=1S/C14H10BrN3O3S/c1-7-12(19)16-14-18(17-7)13(20)11(22-14)6-8-5-9(15)3-4-10(8)21-2/h3-6H,1-2H3/b11-6- UEMYVTYHECWXSR-WDZFZDKYSA-N 50177029 CHEMBL3814269 Serine/threonine-protein kinase PLK1 Homo sapiens 3200 ChEMBL 10.1016/j.bmc.2016.03.023 10.7270/Q2JD4ZQ7 27017542 Watanabe, N; Osada, H RIKEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50177029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50177029&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2190510 346549225 CHEMBL3814269 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50484241 CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2cc(OC[C@@H]3CCCO3)ccc2F)c2c(N)ncnc12 InChI=1S/C27H33FN6O3/c1-17(35)32-6-8-33(9-7-32)18-11-19(12-18)34-14-23(25-26(29)30-16-31-27(25)34)22-13-20(4-5-24(22)28)37-15-21-3-2-10-36-21/h4-5,13-14,16,18-19,21H,2-3,6-12,15H2,1H3,(H2,29,30,31)/t18-,19+,21-/m0/s1 YXLQJZQRBVGUCM-ZVDOUQERSA-N 50156383 CHEMBL3785951 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.02.075 10.7270/Q29K4D4J 26951753 Fairhurst, RA; Marsilje, TH; Stutz, S; Boos, A; Niklaus, M; Chen, B; Jiang, S; Lu, W; Furet, P; McCarthy, C; Stauffer, F; Guagnano, V; Vaupel, A; Michellys, PY; Schnell, C; Jeay, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156383&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 68293638 340133906 CHEMBL3785951 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50493758 C[C@@H](N1c2cc(ccc2C(=O)NC1(C)C)-n1c2cccnc2[nH]c1=O)c1ccccc1 InChI=1S/C24H23N5O2/c1-15(16-8-5-4-6-9-16)29-20-14-17(11-12-18(20)22(30)27-24(29,2)3)28-19-10-7-13-25-21(19)26-23(28)31/h4-15H,1-3H3,(H,27,30)(H,25,26,31)/t15-/m1/s1 WNYKGJHEQVIFGL-OAHLLOKOSA-N 50166588 CHEMBL3798011 Serine/threonine-protein kinase PLK1 Homo sapiens >1000 ChEMBL 10.1016/j.bmc.2016.04.008 10.7270/Q27W6F29 27117263 Katoh, T; Takai, T; Yukawa, T; Tsukamoto, T; Watanabe, E; Mototani, H; Arita, T; Hayashi, H; Nakagawa, H; Klein, MG; Zou, H; Sang, BC; Snell, G; Nakada, Y Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166588&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91933875 341097853 CHEMBL3798011 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50498397 COc1cc(ccc1Nc1ncc2ccnc(N[C@@H](C)C(C)(C)C)c2n1)-c1cnn(C)c1 InChI=1S/C24H29N7O/c1-15(24(2,3)4)28-22-21-17(9-10-25-22)12-26-23(30-21)29-19-8-7-16(11-20(19)32-6)18-13-27-31(5)14-18/h7-15H,1-6H3,(H,25,28)(H,26,29,30)/t15-/m0/s1 XTJZKALDRPVFSN-HNNXBMFYSA-N 241235 US10479788, Example 77::US11046688, Example 77::US9409907, 77 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/acs.jmedchem.5b01811 10.7270/Q2DZ0B6T 27055065 Innocenti, P; Woodward, HL; Solanki, S; Naud, S; Westwood, IM; Cronin, N; Hayes, A; Roberts, J; Henley, AT; Baker, R; Faisal, A; Mak, GW; Box, G; Valenti, M; De Haven Brandon, A; O'Fee, L; Saville, H; Schmitt, J; Matijssen, B; Burke, R; van Montfort, RL; Raynaud, FI; Eccles, SA; Linardopoulos, S; Blagg, J; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=241235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=241235&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 73386882 341093552 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50486827 Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCC2)C1 InChI=1S/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)/t20-,22+ AECDBHGVIIRMOI-GRGXKFILSA-N 50157879 CHEMBL1614712 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.02.075 10.7270/Q29K4D4J 26951753 Fairhurst, RA; Marsilje, TH; Stutz, S; Boos, A; Niklaus, M; Chen, B; Jiang, S; Lu, W; Furet, P; McCarthy, C; Stauffer, F; Guagnano, V; Vaupel, A; Michellys, PY; Schnell, C; Jeay, S Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50157879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50157879&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 66A 5HZN 11476171 340134182 CHEMBL1614712 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50496467 CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCOCC2)c1 InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40) HAYYBYPASCDWEQ-UHFFFAOYSA-N 158154 US10081622, Compound 11::US10370379, Entrectinib::US11059827, Compound Entrectinib::US11267806, Compound T-12::US9029356, 11::US9255087, 11::US9616059, 11 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.6b00064 10.7270/Q27M09TG 27003761 Menichincheri, M; Ardini, E; Magnaghi, P; Avanzi, N; Banfi, P; Bossi, R; Buffa, L; Canevari, G; Ceriani, L; Colombo, M; Corti, L; Donati, D; Fasolini, M; Felder, E; Fiorelli, C; Fiorentini, F; Galvani, A; Isacchi, A; Borgia, AL; Marchionni, C; Nesi, M; Orrenius, C; Panzeri, A; Pesenti, E; Rusconi, L; Saccardo, MB; Vanotti, E; Perrone, E; Orsini, P Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=158154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=158154&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search YMX 5KVT,5FTO 74394320 254815348 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50499749 FC(F)(F)c1ccc(OC(CCNCc2ccccn2)c2ccccc2)cc1 InChI=1S/C22H21F3N2O/c23-22(24,25)18-9-11-20(12-10-18)28-21(17-6-2-1-3-7-17)13-15-26-16-19-8-4-5-14-27-19/h1-12,14,21,26H,13,15-16H2 GQULUVWAOIVUQB-UHFFFAOYSA-N 50176973 CHEMBL3814827 Serine/threonine-protein kinase PLK1 Homo sapiens 50 ChEMBL 10.1021/acs.jmedchem.5b01849 10.7270/Q2FN184P 26881908 Schneider, P; Schneider, G Swiss Federal Institute of Technology (ETH) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50176973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50176973&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71664025 346549187 CHEMBL3814827 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517182 NC(=O)c1sc(cc1OCc1ccccc1Cl)-c1cnc2ccccn12 InChI=1S/C19H14ClN3O2S/c20-13-6-2-1-5-12(13)11-25-15-9-16(26-18(15)19(21)24)14-10-22-17-7-3-4-8-23(14)17/h1-10H,11H2,(H2,21,24) CXKUHYCMRFFSSE-UHFFFAOYSA-N 50297961 3-(2-chlorobenzyloxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL562764 Serine/threonine-protein kinase PLK1 Homo sapiens 1150 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297961&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273808 104139492 CHEMBL562764 ZINC42989565 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517183 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccccc1Cl InChI=1S/C20H16ClN3O2S/c1-12(13-6-2-3-7-14(13)21)26-16-10-17(27-19(16)20(22)25)15-11-23-18-8-4-5-9-24(15)18/h2-12H,1H3,(H2,22,25)/t12-/m1/s1 TXLCIUHAUUABEX-GFCCVEGCSA-N 50297962 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560014 Serine/threonine-protein kinase PLK1 Homo sapiens 310 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297962&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269486 104139493 CHEMBL560014 ZINC43016114 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517184 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccccc1CO InChI=1S/C21H19N3O3S/c1-13(15-7-3-2-6-14(15)12-25)27-17-10-18(28-20(17)21(22)26)16-11-23-19-8-4-5-9-24(16)19/h2-11,13,25H,12H2,1H3,(H2,22,26)/t13-/m1/s1 RRIZJMOVTRNGOB-CYBMUJFWSA-N 50297963 (R)-3-(1-(2-(hydroxymethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560206 Serine/threonine-protein kinase PLK1 Homo sapiens 3750 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297963&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269487 104139494 CHEMBL560206 ZINC43123192 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517185 CC(Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1cc(CO)ccc1Cl InChI=1S/C21H18ClN3O3S/c1-12(14-8-13(11-26)5-6-15(14)22)28-17-9-18(29-20(17)21(23)27)16-10-24-19-4-2-3-7-25(16)19/h2-10,12,26H,11H2,1H3,(H2,23,27) MKCSHXFWWQHKCX-UHFFFAOYSA-N 50297964 3-(1-(2-chloro-5-(hydroxymethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL557945 Serine/threonine-protein kinase PLK1 Homo sapiens 1160 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297964&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273817 104139495 CHEMBL557945 ZINC43011092 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517186 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CO)cc1Cl InChI=1S/C21H18ClN3O3S/c1-12(14-6-5-13(11-26)8-15(14)22)28-17-9-18(29-20(17)21(23)27)16-10-24-19-4-2-3-7-25(16)19/h2-10,12,26H,11H2,1H3,(H2,23,27)/t12-/m1/s1 IJPYPJLGUTXXRY-GFCCVEGCSA-N 50297965 (R)-3-(1-(2-chloro-4-(hydroxymethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560488 Serine/threonine-protein kinase PLK1 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297965&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11661872 104139496 CHEMBL560488 ZINC38210204 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517187 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccc(CO)cn12)c1ccccc1Cl InChI=1S/C21H18ClN3O3S/c1-12(14-4-2-3-5-15(14)22)28-17-8-18(29-20(17)21(23)27)16-9-24-19-7-6-13(11-26)10-25(16)19/h2-10,12,26H,11H2,1H3,(H2,23,27)/t12-/m1/s1 BMJXYGYKLFZMCK-GFCCVEGCSA-N 50297966 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(hydroxymethyl)imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563447 Serine/threonine-protein kinase PLK1 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297966&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11495629 104139497 CHEMBL563447 ZINC43011768 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517188 CNCc1ccc([C@@H](C)Oc2cc(sc2C(N)=O)-c2cnc3ccccn23)c(Cl)c1 InChI=1S/C22H21ClN4O2S/c1-13(15-7-6-14(11-25-2)9-16(15)23)29-18-10-19(30-21(18)22(24)28)17-12-26-20-5-3-4-8-27(17)20/h3-10,12-13,25H,11H2,1-2H3,(H2,24,28)/t13-/m1/s1 UWXBLHZCFUXXQV-CYBMUJFWSA-N 50297967 (R)-3-(1-(2-chloro-4-((methylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL555970 Serine/threonine-protein kinase PLK1 Homo sapiens 36000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297967&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271158 104139498 CHEMBL555970 ZINC43120119 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517189 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN(C)C)cc1Cl InChI=1S/C23H23ClN4O2S/c1-14(16-8-7-15(10-17(16)24)13-27(2)3)30-19-11-20(31-22(19)23(25)29)18-12-26-21-6-4-5-9-28(18)21/h4-12,14H,13H2,1-3H3,(H2,25,29)/t14-/m1/s1 HJHRRHSCQOCGQG-CQSZACIVSA-N 50297968 (R)-3-(1-(2-chloro-4-((dimethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563387 Serine/threonine-protein kinase PLK1 Homo sapiens 48000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297968&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45272066 104139499 CHEMBL563387 ZINC43022271 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517190 CCNCc1ccc([C@@H](C)Oc2cc(sc2C(N)=O)-c2cnc3ccccn23)c(Cl)c1 InChI=1S/C23H23ClN4O2S/c1-3-26-12-15-7-8-16(17(24)10-15)14(2)30-19-11-20(31-22(19)23(25)29)18-13-27-21-6-4-5-9-28(18)21/h4-11,13-14,26H,3,12H2,1-2H3,(H2,25,29)/t14-/m1/s1 ZDIQYDZTCNQUCJ-CQSZACIVSA-N 50297969 (R)-3-(1-(2-chloro-4-((ethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551483 Serine/threonine-protein kinase PLK1 Homo sapiens 37000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297969&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271161 104139500 CHEMBL551483 ZINC43061232 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517191 CC(C)NCc1ccc([C@@H](C)Oc2cc(sc2C(N)=O)-c2cnc3ccccn23)c(Cl)c1 InChI=1S/C24H25ClN4O2S/c1-14(2)27-12-16-7-8-17(18(25)10-16)15(3)31-20-11-21(32-23(20)24(26)30)19-13-28-22-6-4-5-9-29(19)22/h4-11,13-15,27H,12H2,1-3H3,(H2,26,30)/t15-/m1/s1 YUSMYIBQBYVARC-OAHLLOKOSA-N 50297970 (R)-3-(1-(2-chloro-4-((isopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560808 Serine/threonine-protein kinase PLK1 Homo sapiens 68000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297970&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269500 104139501 CHEMBL560808 ZINC43015576 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517192 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC2CC2)cc1Cl InChI=1S/C24H23ClN4O2S/c1-14(17-8-5-15(10-18(17)25)12-27-16-6-7-16)31-20-11-21(32-23(20)24(26)30)19-13-28-22-4-2-3-9-29(19)22/h2-5,8-11,13-14,16,27H,6-7,12H2,1H3,(H2,26,30)/t14-/m1/s1 AQPXGMDXSUVRHV-CQSZACIVSA-N 50297971 (R)-3-(1-(2-chloro-4-((cyclopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL561286 Serine/threonine-protein kinase PLK1 Homo sapiens 220000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297971&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45267772 104139502 CHEMBL561286 ZINC43074451 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517193 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC2CCCC2)cc1Cl InChI=1S/C26H27ClN4O2S/c1-16(19-10-9-17(12-20(19)27)14-29-18-6-2-3-7-18)33-22-13-23(34-25(22)26(28)32)21-15-30-24-8-4-5-11-31(21)24/h4-5,8-13,15-16,18,29H,2-3,6-7,14H2,1H3,(H2,28,32)/t16-/m1/s1 KTMDWHADYAAKOJ-MRXNPFEDSA-N 50297972 (R)-3-(1-(2-chloro-4-((cyclopentylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL564529 Serine/threonine-protein kinase PLK1 Homo sapiens 121000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297972&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269501 104139503 CHEMBL564529 ZINC43072459 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517194 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1Cl InChI=1S/C25H27ClN4O2S/c1-15(17-9-8-16(11-18(17)26)13-29-25(2,3)4)32-20-12-21(33-23(20)24(27)31)19-14-28-22-7-5-6-10-30(19)22/h5-12,14-15,29H,13H2,1-4H3,(H2,27,31)/t15-/m1/s1 ULCNSCGRRQQMIS-OAHLLOKOSA-N 50297973 (R)-3-(1-(4-((tert-butylamino)methyl)-2-chlorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551545 Serine/threonine-protein kinase PLK1 Homo sapiens 48000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297973&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11698712 104139504 CHEMBL551545 ZINC38270151 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517195 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNCCO)cc1Cl InChI=1S/C23H23ClN4O3S/c1-14(16-6-5-15(10-17(16)24)12-26-7-9-29)31-19-11-20(32-22(19)23(25)30)18-13-27-21-4-2-3-8-28(18)21/h2-6,8,10-11,13-14,26,29H,7,9,12H2,1H3,(H2,25,30)/t14-/m1/s1 PPPSOHXHWPYJTF-CQSZACIVSA-N 50297974 (R)-3-(1-(2-chloro-4-((2-hydroxyethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563363 Serine/threonine-protein kinase PLK1 Homo sapiens 184000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297974&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269507 104139505 CHEMBL563363 ZINC43066825 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517196 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNCCCO)cc1Cl InChI=1S/C24H25ClN4O3S/c1-15(17-7-6-16(11-18(17)25)13-27-8-4-10-30)32-20-12-21(33-23(20)24(26)31)19-14-28-22-5-2-3-9-29(19)22/h2-3,5-7,9,11-12,14-15,27,30H,4,8,10,13H2,1H3,(H2,26,31)/t15-/m1/s1 NNKVMZWWDDPOFU-OAHLLOKOSA-N 50297975 (R)-3-(1-(2-chloro-4-((3-hydroxypropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL552084 Serine/threonine-protein kinase PLK1 Homo sapiens 219000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297975&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271168 104139506 CHEMBL552084 ZINC43066554 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517197 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)CO)cc1Cl InChI=1S/C25H27ClN4O3S/c1-15(17-8-7-16(10-18(17)26)12-29-25(2,3)14-31)33-20-11-21(34-23(20)24(27)32)19-13-28-22-6-4-5-9-30(19)22/h4-11,13,15,29,31H,12,14H2,1-3H3,(H2,27,32)/t15-/m1/s1 RQZOGSGNDJUFMB-OAHLLOKOSA-N 50297976 (R)-3-(1-(2-chloro-4-((1-hydroxy-2-methylpropan-2-ylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563411 Serine/threonine-protein kinase PLK1 Homo sapiens 120000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297976&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45270344 104139507 CHEMBL563411 ZINC43024064 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517198 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(F)CC2)cc1Cl InChI=1S/C26H26ClFN4O2S/c1-16(19-6-5-17(12-20(19)27)15-31-10-7-18(28)8-11-31)34-22-13-23(35-25(22)26(29)33)21-14-30-24-4-2-3-9-32(21)24/h2-6,9,12-14,16,18H,7-8,10-11,15H2,1H3,(H2,29,33)/t16-/m1/s1 JVKDICNPGGXTEU-MRXNPFEDSA-N 50297977 (R)-3-(1-(2-chloro-4-((4-fluoropiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563469 Serine/threonine-protein kinase PLK1 Homo sapiens 400000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297977&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269431 104139508 CHEMBL563469 ZINC43121203 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517199 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCN(C)CC2)cc1Cl InChI=1S/C26H28ClN5O2S/c1-17(19-7-6-18(13-20(19)27)16-31-11-9-30(2)10-12-31)34-22-14-23(35-25(22)26(28)33)21-15-29-24-5-3-4-8-32(21)24/h3-8,13-15,17H,9-12,16H2,1-2H3,(H2,28,33)/t17-/m1/s1 YJNSRGNCDWZLPN-QGZVFWFLSA-N 50297978 (R)-3-(1-(2-chloro-4-((4-methylpiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL557126 Serine/threonine-protein kinase PLK1 Homo sapiens 120000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297978&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273759 104139509 CHEMBL557126 ZINC43015824 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517200 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(O)CC2)cc1Cl InChI=1S/C26H27ClN4O3S/c1-16(19-6-5-17(12-20(19)27)15-30-10-7-18(32)8-11-30)34-22-13-23(35-25(22)26(28)33)21-14-29-24-4-2-3-9-31(21)24/h2-6,9,12-14,16,18,32H,7-8,10-11,15H2,1H3,(H2,28,33)/t16-/m1/s1 YONUTDIKUWIJBU-MRXNPFEDSA-N 50297979 (R)-3-(1-(2-chloro-4-((4-hydroxypiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL564067 Serine/threonine-protein kinase PLK1 Homo sapiens 390000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297979&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271969 104139510 CHEMBL564067 ZINC43018163 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517201 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(O)C2)cc1Cl InChI=1S/C25H25ClN4O3S/c1-15(18-6-5-16(10-19(18)26)13-29-9-7-17(31)14-29)33-21-11-22(34-24(21)25(27)32)20-12-28-23-4-2-3-8-30(20)23/h2-6,8,10-12,15,17,31H,7,9,13-14H2,1H3,(H2,27,32)/t15-,17?/m1/s1 KSZQDCYDVPKHGA-LDCVWXEPSA-N 50297980 3-((1R)-1-(2-chloro-4-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL562735 Serine/threonine-protein kinase PLK1 Homo sapiens 227000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297980&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271970 104139511 CHEMBL562735 ZINC52566038 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517202 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCNC(=O)C2)cc1Cl InChI=1S/C25H24ClN5O3S/c1-15(17-6-5-16(10-18(17)26)13-30-9-7-28-23(32)14-30)34-20-11-21(35-24(20)25(27)33)19-12-29-22-4-2-3-8-31(19)22/h2-6,8,10-12,15H,7,9,13-14H2,1H3,(H2,27,33)(H,28,32)/t15-/m1/s1 KDBHWYQEQOHRMN-OAHLLOKOSA-N 50297981 (R)-3-(1-(2-chloro-4-((3-oxopiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL550475 Serine/threonine-protein kinase PLK1 Homo sapiens 1700000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297981&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271090 104139512 CHEMBL550475 ZINC43018472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517203 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCS(=O)(=O)CC2)cc1Cl InChI=1S/C25H25ClN4O4S2/c1-16(18-6-5-17(12-19(18)26)15-29-8-10-36(32,33)11-9-29)34-21-13-22(35-24(21)25(27)31)20-14-28-23-4-2-3-7-30(20)23/h2-7,12-14,16H,8-11,15H2,1H3,(H2,27,31)/t16-/m1/s1 WXFSRZIOBUJEBP-MRXNPFEDSA-N 50297982 3-{(R)-1-[2-Chloro-4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenyl]-ethoxy}-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxylic acid amide::CHEMBL552348 Serine/threonine-protein kinase PLK1 Homo sapiens 400000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297982&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271975 104139513 CHEMBL552348 ZINC43064221 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517204 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1F InChI=1S/C25H27FN4O2S/c1-15(17-9-8-16(11-18(17)26)13-29-25(2,3)4)32-20-12-21(33-23(20)24(27)31)19-14-28-22-7-5-6-10-30(19)22/h5-12,14-15,29H,13H2,1-4H3,(H2,27,31)/t15-/m1/s1 KDLFHICIJUKVAM-OAHLLOKOSA-N 50297983 (R)-3-(1-(4-((tert-butylamino)methyl)-2-fluorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL559888 Serine/threonine-protein kinase PLK1 Homo sapiens 290000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297983&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45267711 104139514 CHEMBL559888 ZINC43078720 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517205 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1C(F)F InChI=1S/C26H28F2N4O2S/c1-15(17-9-8-16(11-18(17)24(27)28)13-31-26(2,3)4)34-20-12-21(35-23(20)25(29)33)19-14-30-22-7-5-6-10-32(19)22/h5-12,14-15,24,31H,13H2,1-4H3,(H2,29,33)/t15-/m1/s1 TXQWUULCESCGAP-OAHLLOKOSA-N 50297984 (R)-3-(1-(4-((tert-butylamino)methyl)-2-(difluoromethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551078 Serine/threonine-protein kinase PLK1 Homo sapiens 82000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297984&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271099 104139515 CHEMBL551078 ZINC43066185 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517206 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1OC(F)F InChI=1S/C26H28F2N4O3S/c1-15(17-9-8-16(13-31-26(2,3)4)11-19(17)35-25(27)28)34-20-12-21(36-23(20)24(29)33)18-14-30-22-7-5-6-10-32(18)22/h5-12,14-15,25,31H,13H2,1-4H3,(H2,29,33)/t15-/m1/s1 JPWPZFYYVIFSAZ-OAHLLOKOSA-N 50297985 (R)-3-(1-(4-((tert-butylamino)methyl)-2-(difluoromethoxy)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551079 Serine/threonine-protein kinase PLK1 Homo sapiens 19000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297985&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11656480 104139516 CHEMBL551079 ZINC43066194 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517207 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2ccccc12 InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-6-2-1-5-12(13)10-28-16-9-17(29-18(16)19(24)27)26-11-25-14-7-3-4-8-15(14)26/h1-9,11H,10H2,(H2,24,27) ITAJXWHXKVYGCF-UHFFFAOYSA-N 28165 5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 16 Serine/threonine-protein kinase PLK1 Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28165&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10409707 58097354 ZINC38798231 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517210 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-n1cnc2ccccc12 InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-6-2-1-5-12(13)10-28-16-9-17(29-18(16)19(24)27)26-11-25-14-7-3-4-8-15(14)26/h1-9,11H,10H2,(H2,24,27) ITAJXWHXKVYGCF-UHFFFAOYSA-N 28165 5-(1H-1,3-benzodiazol-1-yl)-3-{[2-(trifluoromethyl)phenyl]methoxy}thiophene-2-carboxamide::benzimidazole thiophene analogue, 16 Serine/threonine-protein kinase PLK1 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28165&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10409707 58097354 ZINC38798231 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517211 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-c1cnn2ccccc12 InChI=1S/C20H14F3N3O2S/c21-20(22,23)14-6-2-1-5-12(14)11-28-16-9-17(29-18(16)19(24)27)13-10-25-26-8-4-3-7-15(13)26/h1-10H,11H2,(H2,24,27) PAUHHPAGKWCLHG-UHFFFAOYSA-N 50297986 5-(pyrazolo[1,5-a]pyridin-3-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::CHEMBL559891 Serine/threonine-protein kinase PLK1 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297986&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45267745 104139517 CHEMBL559891 ZINC43123518 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517212 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-c1cnc2ccccn12 InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-6-2-1-5-12(13)11-28-15-9-16(29-18(15)19(24)27)14-10-25-17-7-3-4-8-26(14)17/h1-10H,11H2,(H2,24,27) PXZAVZVJLWBDCB-UHFFFAOYSA-N 50297960 5-(imidazo[1,2-a]pyridin-3-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::CHEMBL564431 Serine/threonine-protein kinase PLK1 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297960&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273806 104139491 CHEMBL564431 ZINC43016207 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517213 Cn1cncc1-c1cc(OCc2ccccc2C(F)(F)F)c(s1)C(N)=O InChI=1S/C17H14F3N3O2S/c1-23-9-22-7-12(23)14-6-13(15(26-14)16(21)24)25-8-10-4-2-3-5-11(10)17(18,19)20/h2-7,9H,8H2,1H3,(H2,21,24) YAAQLVDLWFOXTP-UHFFFAOYSA-N 50297987 5-(1-methyl-1H-imidazol-5-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::CHEMBL557878 Serine/threonine-protein kinase PLK1 Homo sapiens 430 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297987&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45272865 104139518 CHEMBL557878 ZINC43020868 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517214 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-c1cnc(N)s1 InChI=1S/C16H12F3N3O2S2/c17-16(18,19)9-4-2-1-3-8(9)7-24-10-5-11(25-13(10)14(20)23)12-6-22-15(21)26-12/h1-6H,7H2,(H2,20,23)(H2,21,22) YJIXSEDXRIXAFX-UHFFFAOYSA-N 50297988 5-(2-aminothiazol-5-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::CHEMBL564877 Serine/threonine-protein kinase PLK1 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297988&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45272047 104139519 CHEMBL564877 ZINC43011417 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517215 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-c1cnc(Nc2ccccc2)s1 InChI=1S/C22H16F3N3O2S2/c23-22(24,25)15-9-5-4-6-13(15)12-30-16-10-17(31-19(16)20(26)29)18-11-27-21(32-18)28-14-7-2-1-3-8-14/h1-11H,12H2,(H2,26,29)(H,27,28) UQTYFWCHJSMTHP-UHFFFAOYSA-N 50297989 5-(2-(phenylamino)thiazol-5-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::CHEMBL550338 Serine/threonine-protein kinase PLK1 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297989&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45272048 104139520 CHEMBL550338 ZINC43018719 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517216 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-c1cnc(NC(=O)c2ccccc2)s1 InChI=1S/C23H16F3N3O3S2/c24-23(25,26)15-9-5-4-8-14(15)12-32-16-10-17(33-19(16)20(27)30)18-11-28-22(34-18)29-21(31)13-6-2-1-3-7-13/h1-11H,12H2,(H2,27,30)(H,28,29,31) IUHBQAJATBWOCT-UHFFFAOYSA-N 50297990 5-(2-benzamidothiazol-5-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::CHEMBL558074 Serine/threonine-protein kinase PLK1 Homo sapiens 2100 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297990&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45272866 104139521 CHEMBL558074 ZINC43060918 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517217 NC(=O)c1sc(cc1OCc1ccccc1Cl)-c1cnc2ccccn12 InChI=1S/C19H14ClN3O2S/c20-13-6-2-1-5-12(13)11-25-15-9-16(26-18(15)19(21)24)14-10-22-17-7-3-4-8-23(14)17/h1-10H,11H2,(H2,21,24) CXKUHYCMRFFSSE-UHFFFAOYSA-N 50297961 3-(2-chlorobenzyloxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL562764 Serine/threonine-protein kinase PLK1 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297961&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273808 104139492 CHEMBL562764 ZINC42989565 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517218 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccccc1Cl InChI=1S/C20H16ClN3O2S/c1-12(13-6-2-3-7-14(13)21)26-16-10-17(27-19(16)20(22)25)15-11-23-18-8-4-5-9-24(15)18/h2-12H,1H3,(H2,22,25)/t12-/m1/s1 TXLCIUHAUUABEX-GFCCVEGCSA-N 50297962 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560014 Serine/threonine-protein kinase PLK1 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297962&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269486 104139493 CHEMBL560014 ZINC43016114 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517219 C[C@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccccc1Cl InChI=1S/C20H16ClN3O2S/c1-12(13-6-2-3-7-14(13)21)26-16-10-17(27-19(16)20(22)25)15-11-23-18-8-4-5-9-24(15)18/h2-12H,1H3,(H2,22,25)/t12-/m0/s1 TXLCIUHAUUABEX-LBPRGKRZSA-N 50297991 (S)-3-(1-(2-chlorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL550741 Serine/threonine-protein kinase PLK1 Homo sapiens 300 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297991&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45272052 104139522 CHEMBL550741 ZINC43016111 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517220 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccccc1CO InChI=1S/C21H19N3O3S/c1-13(15-7-3-2-6-14(15)12-25)27-17-10-18(28-20(17)21(22)26)16-11-23-19-8-4-5-9-24(16)19/h2-11,13,25H,12H2,1H3,(H2,22,26)/t13-/m1/s1 RRIZJMOVTRNGOB-CYBMUJFWSA-N 50297963 (R)-3-(1-(2-(hydroxymethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560206 Serine/threonine-protein kinase PLK1 Homo sapiens 88 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297963&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269487 104139494 CHEMBL560206 ZINC43123192 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517221 CC(Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1cc(CO)ccc1Cl InChI=1S/C21H18ClN3O3S/c1-12(14-8-13(11-26)5-6-15(14)22)28-17-9-18(29-20(17)21(23)27)16-10-24-19-4-2-3-7-25(16)19/h2-10,12,26H,11H2,1H3,(H2,23,27) MKCSHXFWWQHKCX-UHFFFAOYSA-N 50297964 3-(1-(2-chloro-5-(hydroxymethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL557945 Serine/threonine-protein kinase PLK1 Homo sapiens 39 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297964&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273817 104139495 CHEMBL557945 ZINC43011092 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517222 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CO)cc1Cl InChI=1S/C21H18ClN3O3S/c1-12(14-6-5-13(11-26)8-15(14)22)28-17-9-18(29-20(17)21(23)27)16-10-24-19-4-2-3-7-25(16)19/h2-10,12,26H,11H2,1H3,(H2,23,27)/t12-/m1/s1 IJPYPJLGUTXXRY-GFCCVEGCSA-N 50297965 (R)-3-(1-(2-chloro-4-(hydroxymethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560488 Serine/threonine-protein kinase PLK1 Homo sapiens 4.9 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297965&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11661872 104139496 CHEMBL560488 ZINC38210204 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517223 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccc(CO)cn12)c1ccccc1Cl InChI=1S/C21H18ClN3O3S/c1-12(14-4-2-3-5-15(14)22)28-17-8-18(29-20(17)21(23)27)16-9-24-19-7-6-13(11-26)10-25(16)19/h2-10,12,26H,11H2,1H3,(H2,23,27)/t12-/m1/s1 BMJXYGYKLFZMCK-GFCCVEGCSA-N 50297966 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(hydroxymethyl)imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563447 Serine/threonine-protein kinase PLK1 Homo sapiens 7.3 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297966&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11495629 104139497 CHEMBL563447 ZINC43011768 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517224 CC(Oc1cc(sc1C(N)=O)-c1cnc2cc(CO)ccn12)c1ccccc1Cl InChI=1S/C21H18ClN3O3S/c1-12(14-4-2-3-5-15(14)22)28-17-9-18(29-20(17)21(23)27)16-10-24-19-8-13(11-26)6-7-25(16)19/h2-10,12,26H,11H2,1H3,(H2,23,27) KVKSYIHBOFOTSG-UHFFFAOYSA-N 50297992 3-(1-(2-chlorophenyl)ethoxy)-5-(7-(hydroxymethyl)imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551422 Serine/threonine-protein kinase PLK1 Homo sapiens 92 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297992&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45270331 104139523 CHEMBL551422 ZINC43025519 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517225 CNCc1ccc([C@@H](C)Oc2cc(sc2C(N)=O)-c2cnc3ccccn23)c(Cl)c1 InChI=1S/C22H21ClN4O2S/c1-13(15-7-6-14(11-25-2)9-16(15)23)29-18-10-19(30-21(18)22(24)28)17-12-26-20-5-3-4-8-27(17)20/h3-10,12-13,25H,11H2,1-2H3,(H2,24,28)/t13-/m1/s1 UWXBLHZCFUXXQV-CYBMUJFWSA-N 50297967 (R)-3-(1-(2-chloro-4-((methylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL555970 Serine/threonine-protein kinase PLK1 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297967&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271158 104139498 CHEMBL555970 ZINC43120119 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517226 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN(C)C)cc1Cl InChI=1S/C23H23ClN4O2S/c1-14(16-8-7-15(10-17(16)24)13-27(2)3)30-19-11-20(31-22(19)23(25)29)18-12-26-21-6-4-5-9-28(18)21/h4-12,14H,13H2,1-3H3,(H2,25,29)/t14-/m1/s1 HJHRRHSCQOCGQG-CQSZACIVSA-N 50297968 (R)-3-(1-(2-chloro-4-((dimethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563387 Serine/threonine-protein kinase PLK1 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297968&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45272066 104139499 CHEMBL563387 ZINC43022271 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517227 CCNCc1ccc([C@@H](C)Oc2cc(sc2C(N)=O)-c2cnc3ccccn23)c(Cl)c1 InChI=1S/C23H23ClN4O2S/c1-3-26-12-15-7-8-16(17(24)10-15)14(2)30-19-11-20(31-22(19)23(25)29)18-13-27-21-6-4-5-9-28(18)21/h4-11,13-14,26H,3,12H2,1-2H3,(H2,25,29)/t14-/m1/s1 ZDIQYDZTCNQUCJ-CQSZACIVSA-N 50297969 (R)-3-(1-(2-chloro-4-((ethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551483 Serine/threonine-protein kinase PLK1 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297969&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271161 104139500 CHEMBL551483 ZINC43061232 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517228 CC(C)NCc1ccc([C@@H](C)Oc2cc(sc2C(N)=O)-c2cnc3ccccn23)c(Cl)c1 InChI=1S/C24H25ClN4O2S/c1-14(2)27-12-16-7-8-17(18(25)10-16)15(3)31-20-11-21(32-23(20)24(26)30)19-13-28-22-6-4-5-9-29(19)22/h4-11,13-15,27H,12H2,1-3H3,(H2,26,30)/t15-/m1/s1 YUSMYIBQBYVARC-OAHLLOKOSA-N 50297970 (R)-3-(1-(2-chloro-4-((isopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL560808 Serine/threonine-protein kinase PLK1 Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297970&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269500 104139501 CHEMBL560808 ZINC43015576 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517229 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC2CC2)cc1Cl InChI=1S/C24H23ClN4O2S/c1-14(17-8-5-15(10-18(17)25)12-27-16-6-7-16)31-20-11-21(32-23(20)24(26)30)19-13-28-22-4-2-3-9-29(19)22/h2-5,8-11,13-14,16,27H,6-7,12H2,1H3,(H2,26,30)/t14-/m1/s1 AQPXGMDXSUVRHV-CQSZACIVSA-N 50297971 (R)-3-(1-(2-chloro-4-((cyclopropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL561286 Serine/threonine-protein kinase PLK1 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297971&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45267772 104139502 CHEMBL561286 ZINC43074451 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517230 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC2CCCC2)cc1Cl InChI=1S/C26H27ClN4O2S/c1-16(19-10-9-17(12-20(19)27)14-29-18-6-2-3-7-18)33-22-13-23(34-25(22)26(28)32)21-15-30-24-8-4-5-11-31(21)24/h4-5,8-13,15-16,18,29H,2-3,6-7,14H2,1H3,(H2,28,32)/t16-/m1/s1 KTMDWHADYAAKOJ-MRXNPFEDSA-N 50297972 (R)-3-(1-(2-chloro-4-((cyclopentylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL564529 Serine/threonine-protein kinase PLK1 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297972&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269501 104139503 CHEMBL564529 ZINC43072459 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517231 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1Cl InChI=1S/C25H27ClN4O2S/c1-15(17-9-8-16(11-18(17)26)13-29-25(2,3)4)32-20-12-21(33-23(20)24(27)31)19-14-28-22-7-5-6-10-30(19)22/h5-12,14-15,29H,13H2,1-4H3,(H2,27,31)/t15-/m1/s1 ULCNSCGRRQQMIS-OAHLLOKOSA-N 50297973 (R)-3-(1-(4-((tert-butylamino)methyl)-2-chlorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551545 Serine/threonine-protein kinase PLK1 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297973&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11698712 104139504 CHEMBL551545 ZINC38270151 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517232 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNCCO)cc1Cl InChI=1S/C23H23ClN4O3S/c1-14(16-6-5-15(10-17(16)24)12-26-7-9-29)31-19-11-20(32-22(19)23(25)30)18-13-27-21-4-2-3-8-28(18)21/h2-6,8,10-11,13-14,26,29H,7,9,12H2,1H3,(H2,25,30)/t14-/m1/s1 PPPSOHXHWPYJTF-CQSZACIVSA-N 50297974 (R)-3-(1-(2-chloro-4-((2-hydroxyethylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563363 Serine/threonine-protein kinase PLK1 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297974&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269507 104139505 CHEMBL563363 ZINC43066825 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517233 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNCCCO)cc1Cl InChI=1S/C24H25ClN4O3S/c1-15(17-7-6-16(11-18(17)25)13-27-8-4-10-30)32-20-12-21(33-23(20)24(26)31)19-14-28-22-5-2-3-9-29(19)22/h2-3,5-7,9,11-12,14-15,27,30H,4,8,10,13H2,1H3,(H2,26,31)/t15-/m1/s1 NNKVMZWWDDPOFU-OAHLLOKOSA-N 50297975 (R)-3-(1-(2-chloro-4-((3-hydroxypropylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL552084 Serine/threonine-protein kinase PLK1 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297975&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271168 104139506 CHEMBL552084 ZINC43066554 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517234 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)CO)cc1Cl InChI=1S/C25H27ClN4O3S/c1-15(17-8-7-16(10-18(17)26)12-29-25(2,3)14-31)33-20-11-21(34-23(20)24(27)32)19-13-28-22-6-4-5-9-30(19)22/h4-11,13,15,29,31H,12,14H2,1-3H3,(H2,27,32)/t15-/m1/s1 RQZOGSGNDJUFMB-OAHLLOKOSA-N 50297976 (R)-3-(1-(2-chloro-4-((1-hydroxy-2-methylpropan-2-ylamino)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563411 Serine/threonine-protein kinase PLK1 Homo sapiens 23 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297976&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45270344 104139507 CHEMBL563411 ZINC43024064 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517235 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(F)CC2)cc1Cl InChI=1S/C26H26ClFN4O2S/c1-16(19-6-5-17(12-20(19)27)15-31-10-7-18(28)8-11-31)34-22-13-23(35-25(22)26(29)33)21-14-30-24-4-2-3-9-32(21)24/h2-6,9,12-14,16,18H,7-8,10-11,15H2,1H3,(H2,29,33)/t16-/m1/s1 JVKDICNPGGXTEU-MRXNPFEDSA-N 50297977 (R)-3-(1-(2-chloro-4-((4-fluoropiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563469 Serine/threonine-protein kinase PLK1 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297977&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269431 104139508 CHEMBL563469 ZINC43121203 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517236 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCN(C)CC2)cc1Cl InChI=1S/C26H28ClN5O2S/c1-17(19-7-6-18(13-20(19)27)16-31-11-9-30(2)10-12-31)34-22-14-23(35-25(22)26(28)33)21-15-29-24-5-3-4-8-32(21)24/h3-8,13-15,17H,9-12,16H2,1-2H3,(H2,28,33)/t17-/m1/s1 YJNSRGNCDWZLPN-QGZVFWFLSA-N 50297978 (R)-3-(1-(2-chloro-4-((4-methylpiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL557126 Serine/threonine-protein kinase PLK1 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297978&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273759 104139509 CHEMBL557126 ZINC43015824 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517237 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(O)CC2)cc1Cl InChI=1S/C26H27ClN4O3S/c1-16(19-6-5-17(12-20(19)27)15-30-10-7-18(32)8-11-30)34-22-13-23(35-25(22)26(28)33)21-14-29-24-4-2-3-9-31(21)24/h2-6,9,12-14,16,18,32H,7-8,10-11,15H2,1H3,(H2,28,33)/t16-/m1/s1 YONUTDIKUWIJBU-MRXNPFEDSA-N 50297979 (R)-3-(1-(2-chloro-4-((4-hydroxypiperidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL564067 Serine/threonine-protein kinase PLK1 Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297979&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271969 104139510 CHEMBL564067 ZINC43018163 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517238 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCC(O)C2)cc1Cl InChI=1S/C25H25ClN4O3S/c1-15(18-6-5-16(10-19(18)26)13-29-9-7-17(31)14-29)33-21-11-22(34-24(21)25(27)32)20-12-28-23-4-2-3-8-30(20)23/h2-6,8,10-12,15,17,31H,7,9,13-14H2,1H3,(H2,27,32)/t15-,17?/m1/s1 KSZQDCYDVPKHGA-LDCVWXEPSA-N 50297980 3-((1R)-1-(2-chloro-4-((3-hydroxypyrrolidin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL562735 Serine/threonine-protein kinase PLK1 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297980&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271970 104139511 CHEMBL562735 ZINC52566038 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517239 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCNC(=O)C2)cc1Cl InChI=1S/C25H24ClN5O3S/c1-15(17-6-5-16(10-18(17)26)13-30-9-7-28-23(32)14-30)34-20-11-21(35-24(20)25(27)33)19-12-29-22-4-2-3-8-31(19)22/h2-6,8,10-12,15H,7,9,13-14H2,1H3,(H2,27,33)(H,28,32)/t15-/m1/s1 KDBHWYQEQOHRMN-OAHLLOKOSA-N 50297981 (R)-3-(1-(2-chloro-4-((3-oxopiperazin-1-yl)methyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL550475 Serine/threonine-protein kinase PLK1 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297981&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271090 104139512 CHEMBL550475 ZINC43018472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517240 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CN2CCS(=O)(=O)CC2)cc1Cl InChI=1S/C25H25ClN4O4S2/c1-16(18-6-5-17(12-19(18)26)15-29-8-10-36(32,33)11-9-29)34-21-13-22(35-24(21)25(27)31)20-14-28-23-4-2-3-7-30(20)23/h2-7,12-14,16H,8-11,15H2,1H3,(H2,27,31)/t16-/m1/s1 WXFSRZIOBUJEBP-MRXNPFEDSA-N 50297982 3-{(R)-1-[2-Chloro-4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl)-phenyl]-ethoxy}-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxylic acid amide::CHEMBL552348 Serine/threonine-protein kinase PLK1 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297982&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271975 104139513 CHEMBL552348 ZINC43064221 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517241 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1F InChI=1S/C25H27FN4O2S/c1-15(17-9-8-16(11-18(17)26)13-29-25(2,3)4)32-20-12-21(33-23(20)24(27)31)19-14-28-22-7-5-6-10-30(19)22/h5-12,14-15,29H,13H2,1-4H3,(H2,27,31)/t15-/m1/s1 KDLFHICIJUKVAM-OAHLLOKOSA-N 50297983 (R)-3-(1-(4-((tert-butylamino)methyl)-2-fluorophenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL559888 Serine/threonine-protein kinase PLK1 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297983&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45267711 104139514 CHEMBL559888 ZINC43078720 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517242 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1C InChI=1S/C26H30N4O2S/c1-16-12-18(14-29-26(3,4)5)9-10-19(16)17(2)32-21-13-22(33-24(21)25(27)31)20-15-28-23-8-6-7-11-30(20)23/h6-13,15,17,29H,14H2,1-5H3,(H2,27,31)/t17-/m1/s1 JUIWNZRHTWSHBL-QGZVFWFLSA-N 50297993 (R)-3-(1-(4-((tert-butylamino)methyl)-2-methylphenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL557735 Serine/threonine-protein kinase PLK1 Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297993&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273767 104139524 CHEMBL557735 ZINC43022152 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517243 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1C1CC1 InChI=1S/C28H32N4O2S/c1-17(20-11-8-18(15-31-28(2,3)4)13-21(20)19-9-10-19)34-23-14-24(35-26(23)27(29)33)22-16-30-25-7-5-6-12-32(22)25/h5-8,11-14,16-17,19,31H,9-10,15H2,1-4H3,(H2,29,33)/t17-/m1/s1 SIBOXTPPQFRWMZ-QGZVFWFLSA-N 50297994 (R)-3-(1-(4-((tert-butylamino)methyl)-2-cyclopropylphenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL563989 Serine/threonine-protein kinase PLK1 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297994&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45268586 104139525 CHEMBL563989 ZINC43068074 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517244 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1C(F)F InChI=1S/C26H28F2N4O2S/c1-15(17-9-8-16(11-18(17)24(27)28)13-31-26(2,3)4)34-20-12-21(35-23(20)25(29)33)19-14-30-22-7-5-6-10-32(19)22/h5-12,14-15,24,31H,13H2,1-4H3,(H2,29,33)/t15-/m1/s1 TXQWUULCESCGAP-OAHLLOKOSA-N 50297984 (R)-3-(1-(4-((tert-butylamino)methyl)-2-(difluoromethyl)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551078 Serine/threonine-protein kinase PLK1 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297984&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45271099 104139515 CHEMBL551078 ZINC43066185 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517181 NC(=O)c1sc(cc1OCc1ccccc1C(F)(F)F)-c1cnc2ccccn12 InChI=1S/C20H14F3N3O2S/c21-20(22,23)13-6-2-1-5-12(13)11-28-15-9-16(29-18(15)19(24)27)14-10-25-17-7-3-4-8-26(14)17/h1-10H,11H2,(H2,24,27) PXZAVZVJLWBDCB-UHFFFAOYSA-N 50297960 5-(imidazo[1,2-a]pyridin-3-yl)-3-(2-(trifluoromethyl)benzyloxy)thiophene-2-carboxamide::CHEMBL564431 Serine/threonine-protein kinase PLK1 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297960&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45273806 104139491 CHEMBL564431 ZINC43016207 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517245 C[C@@H](Oc1cc(sc1C(N)=O)-c1cnc2ccccn12)c1ccc(CNC(C)(C)C)cc1OC(F)F InChI=1S/C26H28F2N4O3S/c1-15(17-9-8-16(13-31-26(2,3)4)11-19(17)35-25(27)28)34-20-12-21(36-23(20)24(29)33)18-14-30-22-7-5-6-10-32(18)22/h5-12,14-15,25,31H,13H2,1-4H3,(H2,29,33)/t15-/m1/s1 JPWPZFYYVIFSAZ-OAHLLOKOSA-N 50297985 (R)-3-(1-(4-((tert-butylamino)methyl)-2-(difluoromethoxy)phenyl)ethoxy)-5-(imidazo[1,2-a]pyridin-3-yl)thiophene-2-carboxamide::CHEMBL551079 Serine/threonine-protein kinase PLK1 Homo sapiens 9.8 ChEMBL 10.1016/j.bmcl.2009.06.084 10.7270/Q22R3RQG 19589677 Sato, Y; Onozaki, Y; Sugimoto, T; Kurihara, H; Kamijo, K; Kadowaki, C; Tsujino, T; Watanabe, A; Otsuki, S; Mitsuya, M; Iida, M; Haze, K; Machida, T; Nakatsuru, Y; Komatani, H; Kotani, H; Iwasawa, Y Banyu Tsukuba Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297985&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11656480 104139516 CHEMBL551079 ZINC43066194 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50517887 COc1cc(cc(OC)c1OC)-c1nc(c[nH]c1=O)-c1c[nH]c2ccccc12 InChI=1S/C21H19N3O4/c1-26-17-8-12(9-18(27-2)20(17)28-3)19-21(25)23-11-16(24-19)14-10-22-15-7-5-4-6-13(14)15/h4-11,22H,1-3H3,(H,23,25) CGXHFSJDSWAEMT-UHFFFAOYSA-N 50192858 CHEMBL3358966 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm500373x 10.7270/Q2ZG6V0R 25007344 Horbert, R; Pinchuk, B; Johannes, E; Schlosser, J; Schmidt, D; Cappel, D; Totzke, F; Schächtele, C; Peifer, C Christian-Albrechts-University of Kiel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192858&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 118723185 350085761 CHEMBL3358966 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50546369 NCCn1cc(-c2cc(-c3cc4ccccc4s3)c3[nH]ncc3c2)c2nc(N)ncc12 InChI=1S/C23H19N7S/c24-5-6-30-12-17(22-18(30)11-26-23(25)28-22)14-7-15-10-27-29-21(15)16(8-14)20-9-13-3-1-2-4-19(13)31-20/h1-4,7-12H,5-6,24H2,(H,27,29)(H2,25,26,28) JPOSFPUHBHRUAX-UHFFFAOYSA-N 50305006 5-(2-aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amine::CHEMBL590109 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.10.103 10.7270/Q2VD6ZJJ 19926477 Harris, CM; Ericsson, AM; Argiriadi, MA; Barberis, C; Borhani, DW; Burchat, A; Calderwood, DJ; Cunha, GA; Dixon, RW; Frank, KE; Johnson, EF; Kamens, J; Kwak, S; Li, B; Mullen, KD; Perron, DC; Wang, L; Wishart, N; Wu, X; Zhang, X; Zmetra, TR; Talanian, RV Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305006&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46224684 104159367 CHEMBL590109 ZINC45335993 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50551784 CC(=O)N1CCC(CC1)Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H23N7O2/c1-10(26)25-7-5-12(6-8-25)21-18-20-9-11-3-4-13-15(17(19)27)23-24(2)16(13)14(11)22-18/h9,12H,3-8H2,1-2H3,(H2,19,27)(H,20,21,22) CQWBHMMWZICZRH-UHFFFAOYSA-N 50307535 8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL599224 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901710h 10.7270/Q2N879W9 20141146 Traquandi, G; Ciomei, M; Ballinari, D; Casale, E; Colombo, N; Croci, V; Fiorentini, F; Isacchi, A; Longo, A; Mercurio, C; Panzeri, A; Pastori, W; Pevarello, P; Volpi, D; Roussel, P; Vulpetti, A; Brasca, MG Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307535&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45139989 104161896 CHEMBL599224 ZINC45356657 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50551649 Cn1nc(C(N)=O)c2CCc3cnc(NC4CCN(CC4)C(=O)c4ccccc4)nc3-c12 InChI=1S/C23H25N7O2/c1-29-20-17(19(28-29)21(24)31)8-7-15-13-25-23(27-18(15)20)26-16-9-11-30(12-10-16)22(32)14-5-3-2-4-6-14/h2-6,13,16H,7-12H2,1H3,(H2,24,31)(H,25,26,27) DIASEXMEBNQQHZ-UHFFFAOYSA-N 50307506 1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL599428 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901710h 10.7270/Q2N879W9 20141146 Traquandi, G; Ciomei, M; Ballinari, D; Casale, E; Colombo, N; Croci, V; Fiorentini, F; Isacchi, A; Longo, A; Mercurio, C; Panzeri, A; Pastori, W; Pevarello, P; Volpi, D; Roussel, P; Vulpetti, A; Brasca, MG Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307506&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45139991 104161867 CHEMBL599428 ZINC45373710 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50551689 CNC(=O)c1nn(C)c-2c1CCc1cnc(NC3CCN(CC3)C(=O)C3CCN(CC3)S(C)(=O)=O)nc-21 InChI=1S/C24H34N8O4S/c1-25-22(33)20-18-5-4-16-14-26-24(28-19(16)21(18)30(2)29-20)27-17-8-10-31(11-9-17)23(34)15-6-12-32(13-7-15)37(3,35)36/h14-15,17H,4-13H2,1-3H3,(H,25,33)(H,26,27,28) KOLSEKSFVMGHDV-UHFFFAOYSA-N 50307507 CHEMBL597754::N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901710h 10.7270/Q2N879W9 20141146 Traquandi, G; Ciomei, M; Ballinari, D; Casale, E; Colombo, N; Croci, V; Fiorentini, F; Isacchi, A; Longo, A; Mercurio, C; Panzeri, A; Pastori, W; Pevarello, P; Volpi, D; Roussel, P; Vulpetti, A; Brasca, MG Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307507&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46233287 104161868 CHEMBL597754 ZINC45356449 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50571340 O=C(Cc1ccccc1)Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2cccc(c2)N2CCOCC2)n1 InChI=1S/C33H29N7O2S/c41-29(20-23-6-2-1-3-7-23)35-25-9-4-8-24(21-25)30-31(40-16-19-43-33(40)38-30)28-12-13-34-32(37-28)36-26-10-5-11-27(22-26)39-14-17-42-18-15-39/h1-13,16,19,21-22H,14-15,17-18,20H2,(H,35,41)(H,34,36,37) XKZQZMSAWVDRSP-UHFFFAOYSA-N 50315888 CHEMBL1090360::N-(3-(5-(2-(3-morpholinophenylamino)pyrimidin-4-yl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-phenylacetamide Serine/threonine-protein kinase PLK1 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2010.03.015 10.7270/Q2M908VT 20346655 Fidanze, SD; Erickson, SA; Wang, GT; Mantei, R; Clark, RF; Sorensen, BK; Bamaung, NY; Kovar, P; Johnson, EF; Swinger, KK; Stewart, KD; Zhang, Q; Tucker, LA; Pappano, WN; Wilsbacher, JL; Wang, J; Sheppard, GS; Bell, RL; Davidsen, SK; Hubbard, RD Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50315888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50315888&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886323 104150249 CHEMBL1090360 ZINC49793657 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576272 COc1cc(ccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O)N1CCN(C)CC1 InChI=1S/C23H28N8O2/c1-29-8-10-31(11-9-29)15-5-7-17(18(12-15)33-3)26-23-25-13-14-4-6-16-20(22(24)32)28-30(2)21(16)19(14)27-23/h5,7,12-13H,4,6,8-11H2,1-3H3,(H2,24,32)(H,25,26,27) JETXRGKNZYUPEF-UHFFFAOYSA-N 50318063 8-{[2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1095717 Serine/threonine-protein kinase PLK1 Homo sapiens 40 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318063&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887222 104152424 CHEMBL1095717 ZINC53276122 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576278 COC(=O)c1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C19H18N6O3/c1-25-16-12(15(24-25)17(20)26)8-7-10-9-21-19(23-14(10)16)22-13-6-4-3-5-11(13)18(27)28-2/h3-6,9H,7-8H2,1-2H3,(H2,20,26)(H,21,22,23) IUMSYMLFJDPWFR-UHFFFAOYSA-N 50318066 CHEMBL1094484::Methyl 2-[(3-Carbamoyl-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazolin-8-yl)amino]benzoate Serine/threonine-protein kinase PLK1 Homo sapiens 1117 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318066&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887101 104152427 CHEMBL1094484 ZINC49113126 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576284 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4-c4ccccc4)nc3-c12 InChI=1S/C23H20N6O/c1-29-21-17(20(28-29)22(24)30)12-11-15-13-25-23(27-19(15)21)26-18-10-6-5-9-16(18)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H2,24,30)(H,25,26,27) HHVNOYWPFOOKTR-UHFFFAOYSA-N 50318069 8-(Biphenyl-2-ylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide::CHEMBL1094817 Serine/threonine-protein kinase PLK1 Homo sapiens 1565 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318069&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887104 104152430 CHEMBL1094817 ZINC49072542 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576286 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4C(=O)c4ccccc4)nc3-c12 InChI=1S/C24H20N6O2/c1-30-21-17(20(29-30)23(25)32)12-11-15-13-26-24(28-19(15)21)27-18-10-6-5-9-16(18)22(31)14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H2,25,32)(H,26,27,28) NFRDZRLJAHUABL-UHFFFAOYSA-N 50318070 1-Methyl-8-{[2-(phenylcarbonyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1094821 Serine/threonine-protein kinase PLK1 Homo sapiens 1969 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318070&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887139 104152431 CHEMBL1094821 ZINC49072546 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576287 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4Sc4ccccc4)nc3-c12 InChI=1S/C23H20N6OS/c1-29-21-16(20(28-29)22(24)30)12-11-14-13-25-23(27-19(14)21)26-17-9-5-6-10-18(17)31-15-7-3-2-4-8-15/h2-10,13H,11-12H2,1H3,(H2,24,30)(H,25,26,27) CAYPPMFQINCSKS-UHFFFAOYSA-N 50318071 1-Methyl-8-{[2-(phenylsulfanyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1094822 Serine/threonine-protein kinase PLK1 Homo sapiens 2033 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318071&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887140 104152432 CHEMBL1094822 ZINC49072917 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576288 CN1CCN(CC1)c1cccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1C(C)=O InChI=1S/C24H28N8O2/c1-14(33)19-17(5-4-6-18(19)32-11-9-30(2)10-12-32)27-24-26-13-15-7-8-16-21(23(25)34)29-31(3)22(16)20(15)28-24/h4-6,13H,7-12H2,1-3H3,(H2,25,34)(H,26,27,28) AWRGMQGBSTVGKQ-UHFFFAOYSA-N 50318068 8-{[2-Acetyl-3-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1097374 Serine/threonine-protein kinase PLK1 Homo sapiens 2051 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318068&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887189 104152429 CHEMBL1097374 ZINC49088985 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576289 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4C(N)=O)nc3-c12 InChI=1S/C18H17N7O2/c1-25-15-11(14(24-25)17(20)27)7-6-9-8-21-18(23-13(9)15)22-12-5-3-2-4-10(12)16(19)26/h2-5,8H,6-7H2,1H3,(H2,19,26)(H2,20,27)(H,21,22,23) AMVGWQXCPUQNTI-UHFFFAOYSA-N 50318072 8-[(2-Carbamoylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1094815 Serine/threonine-protein kinase PLK1 Homo sapiens 2076 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318072&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887102 104152433 CHEMBL1094815 ZINC49113258 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576293 CC(=O)Nc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C19H19N7O2/c1-10(27)22-13-5-3-4-6-14(13)23-19-21-9-11-7-8-12-16(18(20)28)25-26(2)17(12)15(11)24-19/h3-6,9H,7-8H2,1-2H3,(H2,20,28)(H,22,27)(H,21,23,24) KNXOPPMRMUDBIP-UHFFFAOYSA-N 50318064 8-{[2-(Acetylamino)phenyl]amino}-1-methyl-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1097373 Serine/threonine-protein kinase PLK1 Homo sapiens 2523 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318064&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887188 104152425 CHEMBL1097373 ZINC49784253 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576297 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4S(N)(=O)=O)nc3-c12 InChI=1S/C17H17N7O3S/c1-24-15-10(14(23-24)16(18)25)7-6-9-8-20-17(22-13(9)15)21-11-4-2-3-5-12(11)28(19,26)27/h2-5,8H,6-7H2,1H3,(H2,18,25)(H2,19,26,27)(H,20,21,22) YLYRUFVSUXSETO-UHFFFAOYSA-N 50318067 1-Methyl-8-[(2-sulfamoylphenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1094816 Serine/threonine-protein kinase PLK1 Homo sapiens 3733 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318067&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887103 104152428 CHEMBL1094816 ZINC49072211 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576299 CNC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C18H18N6O/c1-19-17(25)15-13-9-8-11-10-20-18(21-12-6-4-3-5-7-12)22-14(11)16(13)24(2)23-15/h3-7,10H,8-9H2,1-2H3,(H,19,25)(H,20,21,22) UOZGSFYRTXKQQR-UHFFFAOYSA-N 31533 pyrazolo[4,3-h]quinazoline-3-carboxamide, 16 Serine/threonine-protein kinase PLK1 Homo sapiens 4215 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44236353 172097434 ZINC42201316 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576300 CCOC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C19H19N5O2/c1-3-26-18(25)16-14-10-9-12-11-20-19(21-13-7-5-4-6-8-13)22-15(12)17(14)24(2)23-16/h4-8,11H,3,9-10H2,1-2H3,(H,20,21,22) XCLOVJZYWDYYRT-UHFFFAOYSA-N 50318075 CHEMBL1098059::ethyl 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318075&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44232942 104152436 CHEMBL1098059 ZINC49785017 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576302 Cn1nc(C(=O)NC2CC2)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C20H20N6O/c1-26-18-15(17(25-26)19(27)22-14-8-9-14)10-7-12-11-21-20(24-16(12)18)23-13-5-3-2-4-6-13/h2-6,11,14H,7-10H2,1H3,(H,22,27)(H,21,23,24) DXZFQTAPRSQZBA-UHFFFAOYSA-N 31534 pyrazolo[4,3-h]quinazoline-3-carboxamide, 17 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45269647 172097435 ZINC42201310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576303 Cn1nc(C(=O)NC2CCCC2)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C22H24N6O/c1-28-20-17(19(27-28)21(29)24-15-9-5-6-10-15)12-11-14-13-23-22(26-18(14)20)25-16-7-3-2-4-8-16/h2-4,7-8,13,15H,5-6,9-12H2,1H3,(H,24,29)(H,23,25,26) JBZSHFMYVGCDBI-UHFFFAOYSA-N 31536 pyrazolo[4,3-h]quinazoline-3-carboxamide, 19 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31536&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44235884 172097437 ZINC43075886 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576305 Cn1nc(C(=O)Nc2ccccc2)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C23H20N6O/c1-29-21-18(20(28-29)22(30)25-16-8-4-2-5-9-16)13-12-15-14-24-23(27-19(15)21)26-17-10-6-3-7-11-17/h2-11,14H,12-13H2,1H3,(H,25,30)(H,24,26,27) VRZQAXBLQMWLAF-UHFFFAOYSA-N 31537 pyrazolo[4,3-h]quinazoline-3-carboxamide, 20 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31537&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11486283 172097438 ZINC42201308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576325 CSc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H18N6OS/c1-24-16-11(15(23-24)17(19)25)8-7-10-9-20-18(22-14(10)16)21-12-5-3-4-6-13(12)26-2/h3-6,9H,7-8H2,1-2H3,(H2,19,25)(H,20,21,22) UNZVQIJLQQYQLN-UHFFFAOYSA-N 50318076 1-Methyl-8-{[2-(methylsulfanyl)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1094478 Serine/threonine-protein kinase PLK1 Homo sapiens 97 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318076&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887069 104152437 CHEMBL1094478 ZINC49113125 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576326 CN1CCN(CC1)c1ccc(C(C)=O)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H28N8O2/c1-14(33)17-7-5-16(32-10-8-30(2)9-11-32)12-19(17)27-24-26-13-15-4-6-18-21(23(25)34)29-31(3)22(18)20(15)28-24/h5,7,12-13H,4,6,8-11H2,1-3H3,(H2,25,34)(H,26,27,28) ZVEYLHVRYMGPSI-UHFFFAOYSA-N 50318079 8-{[2-Acetyl-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1095716 Serine/threonine-protein kinase PLK1 Homo sapiens 109 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318079&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24992864 104152440 CHEMBL1095716 ZINC49089030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576327 Cn1nc(C(O)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C17H15N5O2/c1-22-15-12(14(21-22)16(23)24)8-7-10-9-18-17(20-13(10)15)19-11-5-3-2-4-6-11/h2-6,9H,7-8H2,1H3,(H,23,24)(H,18,19,20) ZOBRPBVIEUWYJR-UHFFFAOYSA-N 50318080 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid::CHEMBL1098060 Serine/threonine-protein kinase PLK1 Homo sapiens 110 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318080&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search P49 2WIP 44129603 104152441 CHEMBL1098060 DB08355 ZINC39001795 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576328 CNc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H19N7O/c1-20-12-5-3-4-6-13(12)22-18-21-9-10-7-8-11-15(17(19)26)24-25(2)16(11)14(10)23-18/h3-6,9,20H,7-8H2,1-2H3,(H2,19,26)(H,21,22,23) QXAKKDDDYAESLJ-UHFFFAOYSA-N 50318061 1-Methyl-8-{[2-(methylamino)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1095457 Serine/threonine-protein kinase PLK1 Homo sapiens 110 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318061&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24992862 104152422 CHEMBL1095457 ZINC49073264 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576331 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4F)nc3-c12 InChI=1S/C17H15FN6O/c1-24-15-10(14(23-24)16(19)25)7-6-9-8-20-17(22-13(9)15)21-12-5-3-2-4-11(12)18/h2-5,8H,6-7H2,1H3,(H2,19,25)(H,20,21,22) OYDGHJTZNAFKAQ-UHFFFAOYSA-N 50318062 8-[(2-Fluorophenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1095771 Serine/threonine-protein kinase PLK1 Homo sapiens 125 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318062&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887070 104152423 CHEMBL1095771 ZINC49784613 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576334 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4N)nc3-c12 InChI=1S/C17H17N7O/c1-24-15-10(14(23-24)16(19)25)7-6-9-8-20-17(22-13(9)15)21-12-5-3-2-4-11(12)18/h2-5,8H,6-7,18H2,1H3,(H2,19,25)(H,20,21,22) DPROZSHCTFNYSW-UHFFFAOYSA-N 50318074 8-[(2-Aminophenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1097022 Serine/threonine-protein kinase PLK1 Homo sapiens 150 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318074&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887187 104152435 CHEMBL1097022 ZINC49125762 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576337 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4Oc4ccccc4)nc3-c12 InChI=1S/C23H20N6O2/c1-29-21-16(20(28-29)22(24)30)12-11-14-13-25-23(27-19(14)21)26-17-9-5-6-10-18(17)31-15-7-3-2-4-8-15/h2-10,13H,11-12H2,1H3,(H2,24,30)(H,25,26,27) GYDZFEKAOMUPJL-UHFFFAOYSA-N 50318065 1-Methyl-8-[(2-phenoxyphenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1096095 Serine/threonine-protein kinase PLK1 Homo sapiens 278 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318065&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887105 104152426 CHEMBL1096095 ZINC49112762 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576340 CC(C)c1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C20H22N6O/c1-11(2)13-6-4-5-7-15(13)23-20-22-10-12-8-9-14-17(19(21)27)25-26(3)18(14)16(12)24-20/h4-7,10-11H,8-9H2,1-3H3,(H2,21,27)(H,22,23,24) ANAAVHLLZPPWCU-UHFFFAOYSA-N 50318082 1-Methyl-8-{[2-(propan-2-yl)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1095772 Serine/threonine-protein kinase PLK1 Homo sapiens 365 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318082&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887071 104152443 CHEMBL1095772 ZINC49112289 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576342 CN1CCN(CC1)c1ccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c(c1)C(C)=O InChI=1S/C24H28N8O2/c1-14(33)18-12-16(32-10-8-30(2)9-11-32)5-7-19(18)27-24-26-13-15-4-6-17-21(23(25)34)29-31(3)22(17)20(15)28-24/h5,7,12-13H,4,6,8-11H2,1-3H3,(H2,25,34)(H,26,27,28) BNGFMEOSJHFCLA-UHFFFAOYSA-N 50318073 8-{[2-Acetyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1096028 Serine/threonine-protein kinase PLK1 Homo sapiens 464 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318073&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887190 104152434 CHEMBL1096028 ZINC49112504 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576347 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4Cc4ccccc4)nc3-c12 InChI=1S/C24H22N6O/c1-30-22-18(21(29-30)23(25)31)12-11-17-14-26-24(28-20(17)22)27-19-10-6-5-9-16(19)13-15-7-3-2-4-8-15/h2-10,14H,11-13H2,1H3,(H2,25,31)(H,26,27,28) HHYUCVASUIGARF-UHFFFAOYSA-N 50318084 8-[(2-Benzylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094488 Serine/threonine-protein kinase PLK1 Homo sapiens 943 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318084&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887137 104152445 CHEMBL1094488 ZINC49073517 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576348 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4Nc4ccccc4)nc3-c12 InChI=1S/C23H21N7O/c1-30-21-16(20(29-30)22(24)31)12-11-14-13-25-23(28-19(14)21)27-18-10-6-5-9-17(18)26-15-7-3-2-4-8-15/h2-10,13,26H,11-12H2,1H3,(H2,24,31)(H,25,27,28) JXRYPFSBKNWJBW-UHFFFAOYSA-N 50318083 1-Methyl-8-{[2-(phenylamino)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1094820 Serine/threonine-protein kinase PLK1 Homo sapiens 949 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318083&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887138 104152444 CHEMBL1094820 ZINC49113260 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576378 COc1ccc(cc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O)N1CCN(C)CC1 InChI=1S/C22H19F3N4O4/c1-12-16(13(2)33-28-12)10-29-17-5-4-15(7-18(17)32-11-20(29)30)21(31)27-9-14-3-6-19(26-8-14)22(23,24)25/h3-8H,9-11H2,1-2H3,(H,27,31) IZHDJXVLMSZONH-UHFFFAOYSA-N 41575 CHEMBL1094408::US8614220, A85B1C1Z Serine/threonine-protein kinase PLK1 Homo sapiens 7 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=41575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=41575&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 071 3KB7 24993189 251974447 CHEMBL1094408 ZINC70725351 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576390 NC(=O)c1nn(CC(F)(F)F)c-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C18H15F3N6O/c19-18(20,21)9-27-15-12(14(26-27)16(22)28)7-6-10-8-23-17(25-13(10)15)24-11-4-2-1-3-5-11/h1-5,8H,6-7,9H2,(H2,22,28)(H,23,24,25) HWASNOYCCGHVQF-UHFFFAOYSA-N 50318092 8-(Phenylamino)-1-(2,2,2-trifluoroethyl)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1095709 Serine/threonine-protein kinase PLK1 Homo sapiens 6 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318092&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46223562 104152453 CHEMBL1095709 ZINC49784612 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576398 COc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H18N6O2/c1-24-16-11(15(23-24)17(19)25)8-7-10-9-20-18(22-14(10)16)21-12-5-3-4-6-13(12)26-2/h3-6,9H,7-8H2,1-2H3,(H2,19,25)(H,20,21,22) XEMJTISGDXHELX-UHFFFAOYSA-N 50318081 8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094135 Serine/threonine-protein kinase PLK1 Homo sapiens 42 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318081&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886960 104152442 CHEMBL1094135 ZINC49070510 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576401 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cccc(c4)C(F)(F)F)nc3-c12 InChI=1S/C18H15F3N6O/c1-27-15-12(14(26-27)16(22)28)6-5-9-8-23-17(25-13(9)15)24-11-4-2-3-10(7-11)18(19,20)21/h2-4,7-8H,5-6H2,1H3,(H2,22,28)(H,23,24,25) AHUQZOZSCWOMOS-UHFFFAOYSA-N 50318095 1-Methyl-8-{[3-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1097424 Serine/threonine-protein kinase PLK1 Homo sapiens 51 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886878 104152456 CHEMBL1097424 ZINC49088598 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576402 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C17H16N6O/c1-23-15-12(14(22-23)16(18)24)8-7-10-9-19-17(21-13(10)15)20-11-5-3-2-4-6-11/h2-6,9H,7-8H2,1H3,(H2,18,24)(H,19,20,21) UTHWBIPHRYUJSU-UHFFFAOYSA-N 31532 pyrazolo[4,3-h]quinazoline-3-carboxamide, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 68 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31532&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44236351 172097433 ZINC42201314 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576404 CC(=O)c1cccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C19H18N6O2/c1-10(26)11-4-3-5-13(8-11)22-19-21-9-12-6-7-14-16(18(20)27)24-25(2)17(14)15(12)23-19/h3-5,8-9H,6-7H2,1-2H3,(H2,20,27)(H,21,22,23) OMOOZNJIAYMBSP-UHFFFAOYSA-N 50318088 8-[(3-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1099105 Serine/threonine-protein kinase PLK1 Homo sapiens 100 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318088&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886958 104152449 CHEMBL1099105 ZINC49792571 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576408 COc1cccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C18H18N6O2/c1-24-16-13(15(23-24)17(19)25)7-6-10-9-20-18(22-14(10)16)21-11-4-3-5-12(8-11)26-2/h3-5,8-9H,6-7H2,1-2H3,(H2,19,25)(H,20,21,22) WPIFRGDKXSWKPX-UHFFFAOYSA-N 50318093 8-[(3-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1095448 Serine/threonine-protein kinase PLK1 Homo sapiens 135 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887029 104152454 CHEMBL1095448 ZINC49110265 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576409 NC(=O)c1nn(C2CCCCC2)c-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C22H24N6O/c23-21(29)19-17-12-11-14-13-24-22(25-15-7-3-1-4-8-15)26-18(14)20(17)28(27-19)16-9-5-2-6-10-16/h1,3-4,7-8,13,16H,2,5-6,9-12H2,(H2,23,29)(H,24,25,26) UUINGAOFFFDPBY-UHFFFAOYSA-N 50318096 1-Cyclohexyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide::CHEMBL1094402 Serine/threonine-protein kinase PLK1 Homo sapiens 143 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46223565 104152457 CHEMBL1094402 ZINC49072195 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576413 CC(=O)c1ccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)cc1 InChI=1S/C19H18N6O2/c1-10(26)11-3-6-13(7-4-11)22-19-21-9-12-5-8-14-16(18(20)27)24-25(2)17(14)15(12)23-19/h3-4,6-7,9H,5,8H2,1-2H3,(H2,20,27)(H,21,22,23) XWQNZYCWLMEIBB-UHFFFAOYSA-N 50318089 8-[(4-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1099106 Serine/threonine-protein kinase PLK1 Homo sapiens 197 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318089&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886959 104152450 CHEMBL1099106 ZINC49792572 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576415 NC(=O)c1[nH]nc-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C16H14N6O/c17-15(23)14-11-7-6-9-8-18-16(19-10-4-2-1-3-5-10)20-12(9)13(11)21-22-14/h1-5,8H,6-7H2,(H2,17,23)(H,21,22)(H,18,19,20) ZYQXOZKYXADECC-UHFFFAOYSA-N 50318087 8-(Phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1094401 Serine/threonine-protein kinase PLK1 Homo sapiens 248 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318087&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46223564 104152448 CHEMBL1094401 ZINC49112755 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576416 COc1ccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)cc1 InChI=1S/C18H18N6O2/c1-24-16-13(15(23-24)17(19)25)8-3-10-9-20-18(22-14(10)16)21-11-4-6-12(26-2)7-5-11/h4-7,9H,3,8H2,1-2H3,(H2,19,25)(H,20,21,22) XCYGTFKOOGNUMR-UHFFFAOYSA-N 50318091 8-[(4-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094322 Serine/threonine-protein kinase PLK1 Homo sapiens 256 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318091&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887030 104152452 CHEMBL1094322 ZINC49112141 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576419 CC(=O)c1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C19H18N6O2/c1-10(26)12-5-3-4-6-14(12)22-19-21-9-11-7-8-13-16(18(20)27)24-25(2)17(13)15(11)23-19/h3-6,9H,7-8H2,1-2H3,(H2,20,27)(H,21,22,23) NUQUWKXNHFMEAJ-UHFFFAOYSA-N 50318078 8-[(2-Acetylphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1099104 Serine/threonine-protein kinase PLK1 Homo sapiens 346 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318078&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886957 104152439 CHEMBL1099104 ZINC49112872 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576420 CC(C)n1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C19H20N6O/c1-11(2)25-17-14(16(24-25)18(20)26)9-8-12-10-21-19(23-15(12)17)22-13-6-4-3-5-7-13/h3-7,10-11H,8-9H2,1-2H3,(H2,20,26)(H,21,22,23) OQCYIOKKFGCDSR-UHFFFAOYSA-N 50318100 8-(Phenylamino)-1-(propan-2-yl)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide::CHEMBL1094735 Serine/threonine-protein kinase PLK1 Homo sapiens 430 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318100&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46223566 104152461 CHEMBL1094735 ZINC49115144 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576421 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4C(F)(F)F)nc3-c12 InChI=1S/C18H15F3N6O/c1-27-15-10(14(26-27)16(22)28)7-6-9-8-23-17(25-13(9)15)24-12-5-3-2-4-11(12)18(19,20)21/h2-5,8H,6-7H2,1H3,(H2,22,28)(H,23,24,25) URBLFMVEDFWKGZ-UHFFFAOYSA-N 50318077 1-Methyl-8-{[2-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1097071 Serine/threonine-protein kinase PLK1 Homo sapiens 432 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318077&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886877 104152438 CHEMBL1097071 ZINC49783714 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576422 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4[N+]([O-])=O)nc3-c12 InChI=1S/C17H15N7O3/c1-23-15-10(14(22-23)16(18)25)7-6-9-8-19-17(21-13(9)15)20-11-4-2-3-5-12(11)24(26)27/h2-5,8H,6-7H2,1H3,(H2,18,25)(H,19,20,21) GXNUDSNBBQOPIA-UHFFFAOYSA-N 50318102 1-Methyl-8-[(2-nitrophenyl)amino]-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094810 Serine/threonine-protein kinase PLK1 Homo sapiens 488 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318102&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887031 104152463 CHEMBL1094810 ZINC49071901 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576424 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccc(cc4)C(F)(F)F)nc3-c12 InChI=1S/C18H15F3N6O/c1-27-15-12(14(26-27)16(22)28)7-2-9-8-23-17(25-13(9)15)24-11-5-3-10(4-6-11)18(19,20)21/h3-6,8H,2,7H2,1H3,(H2,22,28)(H,23,24,25) HJKBVLZABNNRFO-UHFFFAOYSA-N 50318090 1-Methyl-8-{[4-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1097429 Serine/threonine-protein kinase PLK1 Homo sapiens 872 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318090&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886956 104152451 CHEMBL1097429 ZINC49784152 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576429 NC(=O)c1nn(c-2c1CCc1cnc(Nc3ccccc3)nc-21)-c1ccccc1 InChI=1S/C22H18N6O/c23-21(29)19-17-12-11-14-13-24-22(25-15-7-3-1-4-8-15)26-18(14)20(17)28(27-19)16-9-5-2-6-10-16/h1-10,13H,11-12H2,(H2,23,29)(H,24,25,26) KGLRLXMTNCPNET-UHFFFAOYSA-N 50318098 1-Phenyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]-quinazoline-3-carboxamide::CHEMBL1094400 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318098&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46223563 104152459 CHEMBL1094400 ZINC49072193 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576430 CN1CCC(CC1)n1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C22H25N7O/c1-28-11-9-16(10-12-28)29-20-17(19(27-29)21(23)30)8-7-14-13-24-22(26-18(14)20)25-15-5-3-2-4-6-15/h2-6,13,16H,7-12H2,1H3,(H2,23,30)(H,24,25,26) ZDEIBVDDZHUQLD-UHFFFAOYSA-N 50318101 1-(1-Methylpiperidin-4-yl)-8-(phenylamino)-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1098057 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318101&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46223796 104152462 CHEMBL1098057 ZINC49125408 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576432 NC(=O)c1nn(CCN2CCCCC2)c-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C23H27N7O/c24-22(31)20-18-10-9-16-15-25-23(26-17-7-3-1-4-8-17)27-19(16)21(18)30(28-20)14-13-29-11-5-2-6-12-29/h1,3-4,7-8,15H,2,5-6,9-14H2,(H2,24,31)(H,25,26,27) ABDGGOBNHQMXIJ-UHFFFAOYSA-N 50318099 8-(Phenylamino)-1-[2-(piperidin-1-yl)ethyl]-4,5-dihydro-1Hpyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1098058 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318099&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46223797 104152460 CHEMBL1098058 ZINC49089537 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576437 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cccc(c4)[N+]([O-])=O)nc3-c12 InChI=1S/C17H15N7O3/c1-23-15-12(14(22-23)16(18)25)6-5-9-8-19-17(21-13(9)15)20-10-3-2-4-11(7-10)24(26)27/h2-4,7-8H,5-6H2,1H3,(H2,18,25)(H,19,20,21) PWURWOZBUAQZAZ-UHFFFAOYSA-N 50318094 1-Methyl-8-[(3-nitrophenyl)amino]-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094811 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318094&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887032 104152455 CHEMBL1094811 ZINC49071903 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576439 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccc(cc4)[N+]([O-])=O)nc3-c12 InChI=1S/C17H15N7O3/c1-23-15-12(14(22-23)16(18)25)7-2-9-8-19-17(21-13(9)15)20-10-3-5-11(6-4-10)24(26)27/h3-6,8H,2,7H2,1H3,(H2,18,25)(H,19,20,21) RNNCVRNBQXSBEN-UHFFFAOYSA-N 50318097 1-Methyl-8-[(4-nitrophenyl)amino]-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1095132 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318097&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46887033 104152458 CHEMBL1095132 ZINC49112094 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50576453 Cc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H18N6O/c1-10-5-3-4-6-13(10)21-18-20-9-11-7-8-12-15(17(19)25)23-24(2)16(12)14(11)22-18/h3-6,9H,7-8H2,1-2H3,(H2,19,25)(H,20,21,22) OXPLZKSKLWBEIM-UHFFFAOYSA-N 50318085 1-Methyl-8-[(2-methylphenyl)amino]-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094477 Serine/threonine-protein kinase PLK1 Homo sapiens 15 ChEMBL 10.1021/jm901713n 10.7270/Q2RF5V5D 20397705 Beria, I; Ballinari, D; Bertrand, JA; Borghi, D; Bossi, RT; Brasca, MG; Cappella, P; Caruso, M; Ceccarelli, W; Ciavolella, A; Cristiani, C; Croci, V; De Ponti, A; Fachin, G; Ferguson, RD; Lansen, J; Moll, JK; Pesenti, E; Posteri, H; Perego, R; Rocchetti, M; Storici, P; Volpi, D; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24992861 104152446 CHEMBL1094477 ZINC49072889 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50561823 CN(C)Cc1ccc(cc1)-c1cnn2c(ccnc12)-c1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C29H24F3N5O/c1-36(2)18-19-9-11-20(12-10-19)25-17-34-37-26(13-14-33-27(25)37)21-5-4-8-24(16-21)35-28(38)22-6-3-7-23(15-22)29(30,31)32/h3-17H,18H2,1-2H3,(H,35,38) AIWJVLQNYNCDSL-UHFFFAOYSA-N 50312057 CHEMBL1087397::N-(3-(3-(4-((dimethylamino)methyl)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide::N-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >2000 ChEMBL 10.1016/j.bmcl.2009.10.049 10.7270/Q2SX6DC7 19864136 Berger, DM; Torres, N; Dutia, M; Powell, D; Ciszewski, G; Gopalsamy, A; Levin, JI; Kim, KH; Xu, W; Wilhelm, J; Hu, Y; Collins, K; Feldberg, L; Kim, S; Frommer, E; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312057&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 831 3II5 24884503 104146418 CHEMBL1087397 ZINC44669088 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50566497 FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1 InChI=1S/C25H16F3N5O/c26-25(27,28)19-5-1-4-18(13-19)24(34)31-20-6-2-3-17(14-20)22-9-12-30-23-15-21(32-33(22)23)16-7-10-29-11-8-16/h1-15H,(H,31,34) LCMNWMABPDVIPG-UHFFFAOYSA-N 50314051 CHEMBL1089082::N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2009.10.074 10.7270/Q2C829F3 19884006 Gopalsamy, A; Ciszewski, G; Shi, M; Berger, D; Hu, Y; Lee, F; Feldberg, L; Frommer, E; Kim, S; Collins, K; Wojciechowicz, D; Mallon, R Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314051&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24822704 104148412 CHEMBL1089082 ZINC49068339 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587391 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccccc1)c1ccccc1C(F)(F)F InChI=1S/C27H20F3N3O2S/c1-16(19-9-5-6-10-20(19)27(28,29)30)35-23-14-24(36-25(23)26(31)34)33-15-32-21-13-18(11-12-22(21)33)17-7-3-2-4-8-17/h2-16H,1H3,(H2,31,34)/t16-/m1/s1 SOPUTTUZNMFVAK-MRXNPFEDSA-N 50323111 (R)-5-(5-phenyl-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209603 Serine/threonine-protein kinase PLK1 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323111&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862588 117644432 CHEMBL1209603 ZINC58487459 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587392 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1ccccc1)c1ccccc1C(F)(F)F InChI=1S/C27H20F3N3O2S/c1-16(19-9-5-6-10-20(19)27(28,29)30)35-23-14-24(36-25(23)26(31)34)33-15-32-21-12-11-18(13-22(21)33)17-7-3-2-4-8-17/h2-16H,1H3,(H2,31,34)/t16-/m1/s1 BFKGTKWTGDQINW-MRXNPFEDSA-N 50323112 (R)-5-(6-phenyl-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209604 Serine/threonine-protein kinase PLK1 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323112&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862589 117644433 CHEMBL1209604 ZINC58487864 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587393 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1C(F)(F)F InChI=1S/C26H19F3N4O2S/c1-15(18-4-2-3-5-19(18)26(27,28)29)35-22-13-23(36-24(22)25(30)34)33-14-32-20-12-17(6-7-21(20)33)16-8-10-31-11-9-16/h2-15H,1H3,(H2,30,34)/t15-/m1/s1 DNFIELFWKQLTEZ-OAHLLOKOSA-N 50323113 (R)-5-(5-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209605 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323113&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862590 117644434 CHEMBL1209605 ZINC58493996 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587394 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1ccncc1)c1ccccc1C(F)(F)F InChI=1S/C26H19F3N4O2S/c1-15(18-4-2-3-5-19(18)26(27,28)29)35-22-13-23(36-24(22)25(30)34)33-14-32-20-7-6-17(12-21(20)33)16-8-10-31-11-9-16/h2-15H,1H3,(H2,30,34)/t15-/m1/s1 CVPAFJFHWHMNPA-OAHLLOKOSA-N 50323114 (R)-5-(6-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209606 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323114&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862591 117644435 CHEMBL1209606 ZINC58498958 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587395 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1Cl InChI=1S/C25H19ClN4O2S/c1-15(18-4-2-3-5-19(18)26)32-22-13-23(33-24(22)25(27)31)30-14-29-20-12-17(6-7-21(20)30)16-8-10-28-11-9-16/h2-15H,1H3,(H2,27,31)/t15-/m1/s1 RTDGHNXXZKSIDE-OAHLLOKOSA-N 50323107 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209674 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323107&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862643 117644428 CHEMBL1209674 ZINC58493964 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587396 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1ccncc1)c1ccccc1Cl InChI=1S/C25H19ClN4O2S/c1-15(18-4-2-3-5-19(18)26)32-22-13-23(33-24(22)25(27)31)30-14-29-20-7-6-17(12-21(20)30)16-8-10-28-11-9-16/h2-15H,1H3,(H2,27,31)/t15-/m1/s1 IBAYIPZJRQHHLX-OAHLLOKOSA-N 50323115 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209675 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323115&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862644 117644436 CHEMBL1209675 ZINC58499128 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587397 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cccnc1)c1ccccc1C(F)(F)F InChI=1S/C26H19F3N4O2S/c1-15(18-6-2-3-7-19(18)26(27,28)29)35-22-12-23(36-24(22)25(30)34)33-14-32-20-11-16(8-9-21(20)33)17-5-4-10-31-13-17/h2-15H,1H3,(H2,30,34)/t15-/m1/s1 OQIVVQXVRCAEIO-OAHLLOKOSA-N 50323116 (R)-5-(5-(pyridin-3-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209676 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323116&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862645 117644437 CHEMBL1209676 ZINC58581427 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587398 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1cccnc1)c1ccccc1C(F)(F)F InChI=1S/C26H19F3N4O2S/c1-15(18-6-2-3-7-19(18)26(27,28)29)35-22-12-23(36-24(22)25(30)34)33-14-32-20-9-8-16(11-21(20)33)17-5-4-10-31-13-17/h2-15H,1H3,(H2,30,34)/t15-/m1/s1 YIJGUCDNKKHCPF-OAHLLOKOSA-N 50323117 (R)-5-(6-(pyridin-3-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209677 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323117&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862646 117644438 CHEMBL1209677 ZINC58502053 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587399 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccccn1)c1ccccc1C(F)(F)F InChI=1S/C26H19F3N4O2S/c1-15(17-6-2-3-7-18(17)26(27,28)29)35-22-13-23(36-24(22)25(30)34)33-14-32-20-12-16(9-10-21(20)33)19-8-4-5-11-31-19/h2-15H,1H3,(H2,30,34)/t15-/m1/s1 GDMBPOYBSJXINX-OAHLLOKOSA-N 50323118 (R)-5-(5-(pyridin-2-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209756 Serine/threonine-protein kinase PLK1 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323118&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862708 117644439 CHEMBL1209756 ZINC58506171 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587400 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cccs1)c1ccccc1C(F)(F)F InChI=1S/C25H18F3N3O2S2/c1-14(16-5-2-3-6-17(16)25(26,27)28)33-20-12-22(35-23(20)24(29)32)31-13-30-18-11-15(8-9-19(18)31)21-7-4-10-34-21/h2-14H,1H3,(H2,29,32)/t14-/m1/s1 ZRGJZUSQJGUWJC-CQSZACIVSA-N 50323119 (R)-5-(5-(thiophen-2-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209757 Serine/threonine-protein kinase PLK1 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323119&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862709 117644440 CHEMBL1209757 ZINC58506290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587401 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccc[nH]1)c1ccccc1C(F)(F)F InChI=1S/C25H19F3N4O2S/c1-14(16-5-2-3-6-17(16)25(26,27)28)34-21-12-22(35-23(21)24(29)33)32-13-31-19-11-15(8-9-20(19)32)18-7-4-10-30-18/h2-14,30H,1H3,(H2,29,33)/t14-/m1/s1 HWIAWKKIXLIVDB-CQSZACIVSA-N 50323120 (R)-5-(5-(1H-pyrrol-2-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209758 Serine/threonine-protein kinase PLK1 Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323120&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862710 117644441 CHEMBL1209758 ZINC58511545 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587402 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cn[nH]c1)c1ccccc1C(F)(F)F InChI=1S/C24H18F3N5O2S/c1-13(16-4-2-3-5-17(16)24(25,26)27)34-20-9-21(35-22(20)23(28)33)32-12-29-18-8-14(6-7-19(18)32)15-10-30-31-11-15/h2-13H,1H3,(H2,28,33)(H,30,31)/t13-/m1/s1 OXHLQUMTZGXDNQ-CYBMUJFWSA-N 50323121 (R)-5-(5-(1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209759 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862711 117644442 CHEMBL1209759 ZINC34948438 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587403 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(C)c1)c1ccccc1C(F)(F)F InChI=1S/C25H20F3N5O2S/c1-14(17-5-3-4-6-18(17)25(26,27)28)35-21-10-22(36-23(21)24(29)34)33-13-30-19-9-15(7-8-20(19)33)16-11-31-32(2)12-16/h3-14H,1-2H3,(H2,29,34)/t14-/m1/s1 PWEVQXOSGNAHIQ-CQSZACIVSA-N 50323122 (R)-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209841 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323122&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46911118 117644443 CHEMBL1209841 ZINC58506559 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587404 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(C)c1)c1ccccc1Cl InChI=1S/C24H20ClN5O2S/c1-14(17-5-3-4-6-18(17)25)32-21-10-22(33-23(21)24(26)31)30-13-27-19-9-15(7-8-20(19)30)16-11-28-29(2)12-16/h3-14H,1-2H3,(H2,26,31)/t14-/m1/s1 OVNJVYZXVSMONK-CQSZACIVSA-N 50323109 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209842 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323109&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862783 117644430 CHEMBL1209842 ZINC34948442 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587405 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1cnn(C)c1)c1ccccc1Cl InChI=1S/C24H20ClN5O2S/c1-14(17-5-3-4-6-18(17)25)32-21-10-22(33-23(21)24(26)31)30-13-27-19-8-7-15(9-20(19)30)16-11-28-29(2)12-16/h3-14H,1-2H3,(H2,26,31)/t14-/m1/s1 AOYIAMTYZLMCGR-CQSZACIVSA-N 50323123 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209843 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323123&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862784 117644444 CHEMBL1209843 ZINC58502157 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587406 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(C)c1)c1ccccc1C(F)(F)F InChI=1S/C27H21F3N4O2S/c1-15-11-18(9-10-32-15)17-7-8-22-21(12-17)33-14-34(22)24-13-23(25(37-24)26(31)35)36-16(2)19-5-3-4-6-20(19)27(28,29)30/h3-14,16H,1-2H3,(H2,31,35)/t16-/m1/s1 VBZGTXLWIIYNTA-MRXNPFEDSA-N 50323124 (R)-5-(5-(2-methylpyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1209844 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323124&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862785 117644445 CHEMBL1209844 ZINC58580894 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587407 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(Cl)c1)c1ccccc1C(F)(F)F InChI=1S/C26H18ClF3N4O2S/c1-14(17-4-2-3-5-18(17)26(28,29)30)36-21-12-23(37-24(21)25(31)35)34-13-33-19-10-15(6-7-20(19)34)16-8-9-32-22(27)11-16/h2-14H,1H3,(H2,31,35)/t14-/m1/s1 KQVLCYKGZVIILC-CQSZACIVSA-N 50323125 (R)-5-(5-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208833 Serine/threonine-protein kinase PLK1 Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323125&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862008 117644446 CHEMBL1208833 ZINC58523719 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587408 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1ccnc(Cl)c1)c1ccccc1C(F)(F)F InChI=1S/C26H18ClF3N4O2S/c1-14(17-4-2-3-5-18(17)26(28,29)30)36-21-12-23(37-24(21)25(31)35)34-13-33-19-7-6-15(10-20(19)34)16-8-9-32-22(27)11-16/h2-14H,1H3,(H2,31,35)/t14-/m1/s1 USVLPTCCOLDCMP-CQSZACIVSA-N 50323126 (R)-5-(6-(2-chloropyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208834 Serine/threonine-protein kinase PLK1 Homo sapiens 53 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323126&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862009 117644447 CHEMBL1208834 ZINC58534338 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587409 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(N)c1)c1ccccc1C(F)(F)F InChI=1S/C26H20F3N5O2S/c1-14(17-4-2-3-5-18(17)26(27,28)29)36-21-12-23(37-24(21)25(31)35)34-13-33-19-10-15(6-7-20(19)34)16-8-9-32-22(30)11-16/h2-14H,1H3,(H2,30,32)(H2,31,35)/t14-/m1/s1 RXHOSXWWMGMFAO-CQSZACIVSA-N 50323108 (R)-5-(5-(2-aminopyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208835 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323108&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862010 117644429 CHEMBL1208835 ZINC43152532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587410 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(N)n1)c1ccccc1C(F)(F)F InChI=1S/C25H19F3N6O2S/c1-13(15-4-2-3-5-16(15)25(26,27)28)36-20-11-21(37-22(20)23(29)35)34-12-32-18-10-14(6-7-19(18)34)17-8-9-31-24(30)33-17/h2-13H,1H3,(H2,29,35)(H2,30,31,33)/t13-/m1/s1 CXJOVIBONXRCNI-CYBMUJFWSA-N 50323110 (R)-5-(5-(2-aminopyrimidin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208892 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323110&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862053 117644431 CHEMBL1208892 ZINC58534691 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587415 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnc(N)nc1)c1ccccc1C(F)(F)F InChI=1S/C25H19F3N6O2S/c1-13(16-4-2-3-5-17(16)25(26,27)28)36-20-9-21(37-22(20)23(29)35)34-12-33-18-8-14(6-7-19(18)34)15-10-31-24(30)32-11-15/h2-13H,1H3,(H2,29,35)(H2,30,31,32)/t13-/m1/s1 LIKSPUHPDSNOHY-CYBMUJFWSA-N 50323127 (R)-5-(5-(2-aminopyrimidin-5-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208893 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323127&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862054 117644448 CHEMBL1208893 ZINC58541354 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587416 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCNCC1)c1ccccc1Cl InChI=1S/C29H27ClN6O2S/c1-18(21-4-2-3-5-22(21)30)38-25-16-27(39-28(25)29(31)37)36-17-34-23-14-19(6-7-24(23)36)20-8-9-33-26(15-20)35-12-10-32-11-13-35/h2-9,14-18,32H,10-13H2,1H3,(H2,31,37)/t18-/m1/s1 VVYUVUVFTYVYIG-GOSISDBHSA-N 50323103 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(piperazin-1-yl)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208894 Serine/threonine-protein kinase PLK1 Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323103&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862055 117644424 CHEMBL1208894 ZINC58555025 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587417 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1Cl InChI=1S/C30H29ClN6O2S/c1-19(22-5-3-4-6-23(22)31)39-26-17-28(40-29(26)30(32)38)37-18-34-24-15-20(7-8-25(24)37)21-9-10-33-27(16-21)36-13-11-35(2)12-14-36/h3-10,15-19H,11-14H2,1-2H3,(H2,32,38)/t19-/m1/s1 ORZOCBRCPCCQDN-LJQANCHMSA-N 50323104 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208958 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323104&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862090 117644425 CHEMBL1208958 ZINC58563791 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587418 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1C(F)(F)F InChI=1S/C31H29F3N6O2S/c1-19(22-5-3-4-6-23(22)31(32,33)34)42-26-17-28(43-29(26)30(35)41)40-18-37-24-15-20(7-8-25(24)40)21-9-10-36-27(16-21)39-13-11-38(2)12-14-39/h3-10,15-19H,11-14H2,1-2H3,(H2,35,41)/t19-/m1/s1 OWRZQDDNDUUITK-LJQANCHMSA-N 50323093 (R)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208959 Serine/threonine-protein kinase PLK1 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862091 117644414 CHEMBL1208959 ZINC58598799 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587419 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCOCC1)c1ccccc1C(F)(F)F InChI=1S/C30H26F3N5O3S/c1-18(21-4-2-3-5-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)39)38-17-36-23-14-19(6-7-24(23)38)20-8-9-35-26(15-20)37-10-12-40-13-11-37/h2-9,14-18H,10-13H2,1H3,(H2,34,39)/t18-/m1/s1 XAEATFZFGRMBDN-GOSISDBHSA-N 50323094 (R)-5-(5-(2-morpholinopyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208960 Serine/threonine-protein kinase PLK1 Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323094&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862092 117644415 CHEMBL1208960 ZINC58591330 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587420 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCN(C)C)c1)c1ccccc1C(F)(F)F InChI=1S/C30H29F3N6O2S/c1-18(21-6-4-5-7-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)40)39-17-37-23-14-19(8-9-24(23)39)20-10-11-35-26(15-20)36-12-13-38(2)3/h4-11,14-18H,12-13H2,1-3H3,(H2,34,40)(H,35,36)/t18-/m1/s1 RTYHQIZCRYJKBV-GOSISDBHSA-N 50323095 (R)-5-(5-(2-(2-(dimethylamino)ethylamino)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide::CHEMBL1208961 Serine/threonine-protein kinase PLK1 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24812745 117644416 CHEMBL1208961 ZINC43196281 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50597321 OC(=O)c1ccc(cc1)C(=O)C(\SCc1ccc(Br)cc1)=C/c1ccc(F)c(c1)[N+]([O-])=O InChI=1S/C23H15BrFNO5S/c24-18-8-1-14(2-9-18)13-32-21(12-15-3-10-19(25)20(11-15)26(30)31)22(27)16-4-6-17(7-5-16)23(28)29/h1-12H,13H2,(H,28,29)/b21-12+ VTLBOGLRMDPIDX-CIAFOILYSA-N 50326061 (E)-4-(2-(4-Bromobenzylthio)-3-(4-fluoro-3-nitrophenyl)acryloyl)benzoic acid::CHEMBL1242482 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1016/j.bmc.2010.01.051 10.7270/Q21Z44N8 20188579 Reddy, MV; Pallela, VR; Cosenza, SC; Mallireddigari, MR; Patti, R; Bonagura, M; Truongcao, M; Akula, B; Jatiani, SS; Reddy, EP Temple University School of Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326061&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24960018 123105176 CHEMBL1242482 ZINC64521352 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50601895 O=C(N[C@H](CN1CCCC1)c1ccccc1)c1cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCOCC3)c2s1 InChI=1S/C29H32N6O3S/c36-28(21-8-10-22(11-9-21)35-14-16-38-17-15-35)31-27-26-23(32-33-27)18-25(39-26)29(37)30-24(19-34-12-4-5-13-34)20-6-2-1-3-7-20/h1-3,6-11,18,24H,4-5,12-17,19H2,(H,30,37)(H2,31,32,33,36)/t24-/m1/s1 ORWIYCURPDKSBI-XMMPIXPASA-N 50327912 3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[3,2-c]pyrazole-5-carboxylic acid((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl)-amide::CHEMBL1258913 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2010.07.048 10.7270/Q2Q240GM 20817473 Bindi, S; Fancelli, D; Alli, C; Berta, D; Bertrand, JA; Cameron, AD; Cappella, P; Carpinelli, P; Cervi, G; Croci, V; D'Anello, M; Forte, B; Giorgini, ML; Marsiglio, A; Moll, J; Pesenti, E; Pittala, V; Pulici, M; Riccardi-Sirtori, F; Roletto, F; Soncini, C; Storici, P; Varasi, M; Volpi, D; Zugnoni, P; Vianello, P Nerviano Medical Sciences Oncology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50327912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50327912&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11847343 123107027 CHEMBL1258913 ZINC43132736 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587421 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCS(C)(=O)=O)c1)c1ccccc1Cl InChI=1S/C28H26ClN5O4S2/c1-17(20-5-3-4-6-21(20)29)38-24-15-26(39-27(24)28(30)35)34-16-33-22-13-18(7-8-23(22)34)19-9-10-31-25(14-19)32-11-12-40(2,36)37/h3-10,13-17H,11-12H2,1-2H3,(H2,30,35)(H,31,32)/t17-/m1/s1 GALNGZPXDPAWDR-QGZVFWFLSA-N 50323096 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-(methylsulfonyl)ethylamino)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208962 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862093 117644417 CHEMBL1208962 ZINC58563884 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587422 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCO)c1)c1ccccc1Cl InChI=1S/C27H24ClN5O3S/c1-16(19-4-2-3-5-20(19)28)36-23-14-25(37-26(23)27(29)35)33-15-32-21-12-17(6-7-22(21)33)18-8-9-30-24(13-18)31-10-11-34/h2-9,12-16,34H,10-11H2,1H3,(H2,29,35)(H,30,31)/t16-/m1/s1 ASTXNDZZOAPTNR-MRXNPFEDSA-N 50323097 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-hydroxyethylamino)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208963 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323097&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24954671 117644418 CHEMBL1208963 ZINC58538121 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587423 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)c1)c1ccccc1Cl InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-17-29(41-30(27)31(33)39)38-18-35-25-15-20(7-8-26(25)38)21-9-12-34-28(16-21)36-22-10-13-37(2)14-11-22/h3-9,12,15-19,22H,10-11,13-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1 VZQLEKQMCOAWNB-LJQANCHMSA-N 50323098 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methylpiperidin-4-ylamino)pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208964 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323098&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46911119 117644419 CHEMBL1208964 ZINC58591331 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587424 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccc(NC2CCN(C)CC2)nc1)c1ccccc1Cl InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-16-29(41-30(27)31(33)39)38-18-35-25-15-20(7-9-26(25)38)21-8-10-28(34-17-21)36-22-11-13-37(2)14-12-22/h3-10,15-19,22H,11-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1 VPGSHWKKZVAVBK-LJQANCHMSA-N 50323099 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(6-(1-methylpiperidin-4-ylamino)pyridin-3-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208965 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323099&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862094 117644420 CHEMBL1208965 ZINC43152533 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587425 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)n1)c1ccccc1Cl InChI=1S/C30H30ClN7O2S/c1-18(21-5-3-4-6-22(21)31)40-26-16-27(41-28(26)29(32)39)38-17-34-24-15-19(7-8-25(24)38)23-9-12-33-30(36-23)35-20-10-13-37(2)14-11-20/h3-9,12,15-18,20H,10-11,13-14H2,1-2H3,(H2,32,39)(H,33,35,36)/t18-/m1/s1 TYQDNFSUWCTPOC-GOSISDBHSA-N 50323105 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methylpiperidin-4-ylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1208966 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323105&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862095 117644426 CHEMBL1208966 ZINC58598800 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587426 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCN2CCOCC2)c1)c1ccccc1Cl InChI=1S/C29H29ClN6O3S/c1-19(22-4-2-3-5-23(22)30)39-26-15-27(40-28(26)29(31)37)36-18-32-24-14-20(6-7-25(24)36)21-16-33-35(17-21)9-8-34-10-12-38-13-11-34/h2-7,14-19H,8-13H2,1H3,(H2,31,37)/t19-/m1/s1 OENQIJZSDDCZNC-LJQANCHMSA-N 50323106 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(2-morpholinoethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209015 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323106&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862126 117644427 CHEMBL1209015 ZINC58564059 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587427 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCN2CCN(C)CC2)c1)c1ccccc1Cl InChI=1S/C30H32ClN7O2S/c1-20(23-5-3-4-6-24(23)31)40-27-16-28(41-29(27)30(32)39)38-19-33-25-15-21(7-8-26(25)38)22-17-34-37(18-22)14-13-36-11-9-35(2)10-12-36/h3-8,15-20H,9-14H2,1-2H3,(H2,32,39)/t20-/m1/s1 NXOJBDCDDRAJDO-HXUWFJFHSA-N 50323100 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(2-(4-methylpiperazin-1-yl)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209016 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323100&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862127 117644421 CHEMBL1209016 ZINC58594410 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587428 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCCN(C)C)c1)c1ccccc1Cl InChI=1S/C28H29ClN6O2S/c1-18(21-7-4-5-8-22(21)29)37-25-14-26(38-27(25)28(30)36)35-17-31-23-13-19(9-10-24(23)35)20-15-32-34(16-20)12-6-11-33(2)3/h4-5,7-10,13-18H,6,11-12H2,1-3H3,(H2,30,36)/t18-/m1/s1 WAMWLVAINQIUBS-GOSISDBHSA-N 50323101 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimethylamino)propyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209017 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323101&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49862128 117644422 CHEMBL1209017 ZINC58538030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50587429 CCN1CCN(CCCn2cc(cn2)-c2ccc3n(cnc3c2)-c2cc(O[C@H](C)c3ccccc3Cl)c(s2)C(N)=O)CC1 InChI=1S/C32H36ClN7O2S/c1-3-37-13-15-38(16-14-37)11-6-12-39-20-24(19-36-39)23-9-10-28-27(17-23)35-21-40(28)30-18-29(31(43-30)32(34)41)42-22(2)25-7-4-5-8-26(25)33/h4-5,7-10,17-22H,3,6,11-16H2,1-2H3,(H2,34,41)/t22-/m1/s1 XWUCTSMJFVUKTR-JOCHJYFZSA-N 50323102 (R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(4-ethylpiperazin-1-yl)propyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1209018 Serine/threonine-protein kinase PLK1 Homo sapiens 1 ChEMBL 10.1016/j.bmcl.2010.06.009 10.7270/Q2MS3SZB 20594842 Rheault, TR; Donaldson, KH; Badiang-Alberti, JG; Davis-Ward, RG; Andrews, CW; Bambal, R; Jackson, JR; Cheung, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323102&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46911173 117644423 CHEMBL1209018 ZINC43152535 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50595692 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50595960 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50597758 CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C InChI=1S/C25H20F3N5O2/c1-15-13-18(32-22(34)16-5-3-6-17(14-16)25(26,27)28)8-9-21(15)35-23-19(7-4-11-30-23)20-10-12-31-24(29-2)33-20/h3-14H,1-2H3,(H,32,34)(H,29,31,33) FFNIWOOLZGAOAB-UHFFFAOYSA-N 50326198 CHEMBL1242977::N-(3-Methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethyl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >8000 ChEMBL 10.1021/jm100394y 10.7270/Q2C829H0 20684549 Cee, VJ; Schenkel, LB; Hodous, BL; Deak, HL; Nguyen, HN; Olivieri, PR; Romero, K; Bak, A; Be, X; Bellon, S; Bush, TL; Cheng, AC; Chung, G; Coats, S; Eden, PM; Hanestad, K; Gallant, PL; Gu, Y; Huang, X; Kendall, RL; Lin, MH; Morrison, MJ; Patel, VF; Radinsky, R; Rose, PE; Ross, S; Sun, JR; Tang, J; Zhao, H; Payton, M; Geuns-Meyer, SD Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326198&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46929544 123105313 CHEMBL1242977 ZINC64553652 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50597788 CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)c2ccccc2Nc2ccccc2)cc1 InChI=1S/C29H24N6O2/c1-30-29-32-19-17-26(35-29)24-11-7-18-31-28(24)37-22-15-13-21(14-16-22)34-27(36)23-10-5-6-12-25(23)33-20-8-3-2-4-9-20/h2-19,33H,1H3,(H,34,36)(H,30,32,35) YRIZEPGWRQGUBO-UHFFFAOYSA-N 50326206 CHEMBL1243200::N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-2-(phenylamino)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >1000 ChEMBL 10.1021/jm100394y 10.7270/Q2C829H0 20684549 Cee, VJ; Schenkel, LB; Hodous, BL; Deak, HL; Nguyen, HN; Olivieri, PR; Romero, K; Bak, A; Be, X; Bellon, S; Bush, TL; Cheng, AC; Chung, G; Coats, S; Eden, PM; Hanestad, K; Gallant, PL; Gu, Y; Huang, X; Kendall, RL; Lin, MH; Morrison, MJ; Patel, VF; Radinsky, R; Rose, PE; Ross, S; Sun, JR; Tang, J; Zhao, H; Payton, M; Geuns-Meyer, SD Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326206&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46929748 123105321 CHEMBL1243200 ZINC64574006 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50597800 CNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nnc(-c3ccc(F)cc3)c3ccccc23)cc1 InChI=1S/C30H22FN7O/c1-32-30-34-18-16-26(36-30)25-7-4-17-33-29(25)39-22-14-12-21(13-15-22)35-28-24-6-3-2-5-23(24)27(37-38-28)19-8-10-20(31)11-9-19/h2-18H,1H3,(H,35,38)(H,32,34,36) DZICJKNDYKNBTO-UHFFFAOYSA-N 50326208 4-(4-Fluorophenyl)-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)-pyridin-2-yloxy)phenyl)phthalazin-1-amine::CHEMBL1243326 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1021/jm100394y 10.7270/Q2C829H0 20684549 Cee, VJ; Schenkel, LB; Hodous, BL; Deak, HL; Nguyen, HN; Olivieri, PR; Romero, K; Bak, A; Be, X; Bellon, S; Bush, TL; Cheng, AC; Chung, G; Coats, S; Eden, PM; Hanestad, K; Gallant, PL; Gu, Y; Huang, X; Kendall, RL; Lin, MH; Morrison, MJ; Patel, VF; Radinsky, R; Rose, PE; Ross, S; Sun, JR; Tang, J; Zhao, H; Payton, M; Geuns-Meyer, SD Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326208&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46929857 123105323 CHEMBL1243326 ZINC64553580 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50594546 CC(=O)Nc1ccc(Nc2ncc(c(Nc3ccccc3C(=O)c3ccccc3)n2)[N+]([O-])=O)cc1 InChI=1S/C25H20N6O4/c1-16(32)27-18-11-13-19(14-12-18)28-25-26-15-22(31(34)35)24(30-25)29-21-10-6-5-9-20(21)23(33)17-7-3-2-4-8-17/h2-15H,1H3,(H,27,32)(H2,26,28,29,30) LOMJSEHTDFISSP-UHFFFAOYSA-N 50326002 2-[4-acetamidyl phenylamino]-4-[2-benzoyl phenylamino]-5-nitropyrimidine::CHEMBL1242101::DAP-81 Serine/threonine-protein kinase PLK1 Homo sapiens 900 ChEMBL 10.1038/nchembio826 10.7270/Q27M0843 17028580 Peters, U; Cherian, J; Kim, JH; Kwok, BH; Kapoor, TM Rockefeller University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326002&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9548005 123105117 CHEMBL1242101 ZINC03986640 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50594547 NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O InChI=1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14) FKRBAXZAJBBIAJ-UHFFFAOYSA-N 50263741 5-Cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide::CHEMBL492008 Serine/threonine-protein kinase PLK1 Homo sapiens 8000 ChEMBL 10.1038/nchembio826 10.7270/Q27M0843 17028580 Peters, U; Cherian, J; Kim, JH; Kwok, BH; Kapoor, TM Rockefeller University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263741&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9548007 104111966 CHEMBL492008 ZINC35212821 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50579905 Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23) GPSZYOIFQZPWEJ-UHFFFAOYSA-N 50277583 2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, 5::4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine::Aminopyrimidine, 9::CHEMBL482967::CYC-116 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277583&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6420138 104120139 CHEMBL482967 ZINC03950132 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50594817 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50596665 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1 ZZSBPGIGIUFJRA-AKIDMACVSA-N 50326054 CHEMBL1240703 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52945601 123105169 CHEMBL1240703 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50596727 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50610513 COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1 InChI=1S/C19H16N2O2/c1-22-14-8-6-13(7-9-14)12-21-16-10-11-20-19-18(16)15-4-2-3-5-17(15)23-19/h2-11H,12H2,1H3,(H,20,21) MNMQBQOLMHVBJT-UHFFFAOYSA-N 50331612 CHEMBL1290072::N-(4-methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine Serine/threonine-protein kinase PLK1 Homo sapiens 271000 ChEMBL 10.1016/j.bmcl.2010.10.004 10.7270/Q2GF0TQS 21035334 Krug, M; Erlenkamp, G; Sippl, W; Schachtele, C; Totzke, F; Hilgeroth, A Martin-Luther-University Halle-Wittenberg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331612&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50908681 123110727 CHEMBL1290072 ZINC64559365 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50610598 Cc1ccc(cc1NC(=O)c1cnn(c1N)-c1ccccc1F)C(=O)Nc1ccon1 InChI=1S/C21H17FN6O3/c1-12-6-7-13(20(29)26-18-8-9-31-27-18)10-16(12)25-21(30)14-11-24-28(19(14)23)17-5-3-2-4-15(17)22/h2-11H,23H2,1H3,(H,25,30)(H,26,27,29) HFTDLOVSQHYBFJ-UHFFFAOYSA-N 50331629 5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphenyl)-1H-pyrazole-4-carboxamide::CHEMBL1290746 Serine/threonine-protein kinase PLK1 Homo sapiens >15000 ChEMBL 10.1016/j.bmcl.2010.10.034 10.7270/Q2BP0319 21035336 Das, J; Moquin, RV; Dyckman, AJ; Li, T; Pitt, S; Zhang, R; Shen, DR; McIntyre, KW; Gillooly, K; Doweyko, AM; Newitt, JA; Sack, JS; Zhang, H; Kiefer, SE; Kish, K; McKinnon, M; Barrish, JC; Dodd, JH; Schieven, GL; Leftheris, K Bristol-Myers Squibb Research and Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331629&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49838879 123110744 CHEMBL1290746 ZINC64560262 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612391 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50608442 CCc1ccsc1-c1cnc(N)c(n1)N1CCC(CC1)C(O)=O InChI=1S/C16H20N4O2S/c1-2-10-5-8-23-13(10)12-9-18-14(17)15(19-12)20-6-3-11(4-7-20)16(21)22/h5,8-9,11H,2-4,6-7H2,1H3,(H2,17,18)(H,21,22) SXVAXEOOBRDRSC-UHFFFAOYSA-N 50330574 1-(3-amino-6-(3-ethylthiophen-2-yl)pyrazin-2-yl)piperidine-4-carboxylic acid::CHEMBL1277019 Serine/threonine-protein kinase PLK1 Homo sapiens 8500 25.00 C ChEMBL 10.1021/jm1008727 10.7270/Q23J3D79 20936789 Whelligan, DK; Solanki, S; Taylor, D; Thomson, DW; Cheung, KM; Boxall, K; Mas-Droux, C; Barillari, C; Burns, S; Grummitt, CG; Collins, I; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330574&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49837568 123109689 CHEMBL1277019 ZINC64447482 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50608443 COc1cc(cc(OC)c1OC)-c1cnc(N)c(n1)N1CC[C@H]([C@@H](C)[C@H]1C)C(O)=O InChI=1S/C21H28N4O5/c1-11-12(2)25(7-6-14(11)21(26)27)20-19(22)23-10-15(24-20)13-8-16(28-3)18(30-5)17(9-13)29-4/h8-12,14H,6-7H2,1-5H3,(H2,22,23)(H,26,27)/t11-,12+,14+/m0/s1 YPKLAWUGDWZBMV-OUCADQQQSA-N 50330575 (-)-(2R,3R,4R)-1-(3-Amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)-2,3-dimethylpiperidine-4-carboxylic Acid::CHEMBL1276848 Serine/threonine-protein kinase PLK1 Homo sapiens 19400 25.00 C ChEMBL 10.1021/jm1008727 10.7270/Q23J3D79 20936789 Whelligan, DK; Solanki, S; Taylor, D; Thomson, DW; Cheung, KM; Boxall, K; Mas-Droux, C; Barillari, C; Burns, S; Grummitt, CG; Collins, I; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330575&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49837564 123109690 CHEMBL1276848 ZINC64453957 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50608470 COc1cc(cc(OC)c1OC)-c1cnc(N)c(n1)N1CCC(CC1)C(O)=O InChI=1S/C19H24N4O5/c1-26-14-8-12(9-15(27-2)16(14)28-3)13-10-21-17(20)18(22-13)23-6-4-11(5-7-23)19(24)25/h8-11H,4-7H2,1-3H3,(H2,20,21)(H,24,25) FFHSQDAETWTILU-UHFFFAOYSA-N 50330578 1-(3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl)piperidine-4-carboxylic acid::1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid::CHEMBL1231522 Serine/threonine-protein kinase PLK1 Homo sapiens 22600 25.00 C ChEMBL 10.1021/jm1008727 10.7270/Q23J3D79 20936789 Whelligan, DK; Solanki, S; Taylor, D; Thomson, DW; Cheung, KM; Boxall, K; Mas-Droux, C; Barillari, C; Burns, S; Grummitt, CG; Collins, I; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50330578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50330578&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BX1 2XKF 46926535 123109693 CHEMBL1231522 ZINC58660889 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612495 ONC(=O)\C=C\c1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C28H20ClFN4O4/c29-23-14-20(5-9-26(23)37-15-17-2-1-3-19(30)12-17)33-28-22-13-18(4-8-24(22)31-16-32-28)25-10-6-21(38-25)7-11-27(35)34-36/h1-14,16,36H,15H2,(H,34,35)(H,31,32,33)/b11-7+ QIGGJMQSVPHSJB-YRNVUSSQSA-N 50332483 3-{5-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino]quinazolin-6-yl}furan-2-yl)-N-hydroxy-acrylamideHydrochlorideMonohydrate::CHEMBL1630107 Serine/threonine-protein kinase PLK1 Homo sapiens 12000 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332483&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855568 125082585 CHEMBL1630107 ZINC66261904 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612496 ONC(=O)\C=C\c1ccc(s1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C28H20ClFN4O3S/c29-23-14-20(5-9-25(23)37-15-17-2-1-3-19(30)12-17)33-28-22-13-18(4-8-24(22)31-16-32-28)26-10-6-21(38-26)7-11-27(35)34-36/h1-14,16,36H,15H2,(H,34,35)(H,31,32,33)/b11-7+ SUBNLERWESOYMX-YRNVUSSQSA-N 50332491 (E)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)thiophen-2-yl)-N-hydroxyacrylamide::CHEMBL1630108 Serine/threonine-protein kinase PLK1 Homo sapiens 2700 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332491&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855569 125082593 CHEMBL1630108 ZINC66262636 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612497 ONC(=O)\C=C\c1cccc(c1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C30H22ClFN4O3/c31-26-16-24(9-11-28(26)39-17-20-4-2-6-23(32)14-20)35-30-25-15-22(8-10-27(25)33-18-34-30)21-5-1-3-19(13-21)7-12-29(37)36-38/h1-16,18,38H,17H2,(H,36,37)(H,33,34,35)/b12-7+ HRIQVCCRXNQUAH-KPKJPENVSA-N 50332494 (E)-3-{3-[4-(3-Chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)-N-hydroxyacrylamide::CHEMBL1630109 Serine/threonine-protein kinase PLK1 Homo sapiens 6800 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332494&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42596953 125082596 CHEMBL1630109 ZINC66262639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612498 ONC(=O)\C=C\c1ccc(cc1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C30H22ClFN4O3/c31-26-16-24(10-12-28(26)39-17-20-2-1-3-23(32)14-20)35-30-25-15-22(9-11-27(25)33-18-34-30)21-7-4-19(5-8-21)6-13-29(37)36-38/h1-16,18,38H,17H2,(H,36,37)(H,33,34,35)/b13-6+ QAQXTNHOYJTPGB-AWNIVKPZSA-N 50332492 (E)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)-N-hydroxyacrylamide::CHEMBL1630110 Serine/threonine-protein kinase PLK1 Homo sapiens 9100 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332492&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855758 125082594 CHEMBL1630110 ZINC66262642 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612499 Nc1ccccc1NC(=O)c1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C32H23ClFN5O3/c33-24-16-22(9-11-29(24)41-17-19-4-3-5-21(34)14-19)38-31-23-15-20(8-10-26(23)36-18-37-31)28-12-13-30(42-28)32(40)39-27-7-2-1-6-25(27)35/h1-16,18H,17,35H2,(H,39,40)(H,36,37,38) DWLVUAOJOFAURW-UHFFFAOYSA-N 50332484 CHEMBL1630111::N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens 3900 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332484&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855759 125082586 CHEMBL1630111 ZINC66262869 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612500 Nc1ccccc1NC(=O)c1ccc(s1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C32H23ClFN5O2S/c33-24-16-22(9-11-28(24)41-17-19-4-3-5-21(34)14-19)38-31-23-15-20(8-10-26(23)36-18-37-31)29-12-13-30(42-29)32(40)39-27-7-2-1-6-25(27)35/h1-16,18H,17,35H2,(H,39,40)(H,36,37,38) NVVASLWKXTZLJN-UHFFFAOYSA-N 50332485 CHEMBL1630112::N-(2-aminophenyl)-5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)thiophene-2-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens 5600 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332485&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855760 125082587 CHEMBL1630112 ZINC66262065 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612501 Nc1ccccc1NC(=O)\C=C\c1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C34H25ClFN5O3/c35-27-18-24(9-13-32(27)43-19-21-4-3-5-23(36)16-21)40-34-26-17-22(8-12-29(26)38-20-39-34)31-14-10-25(44-31)11-15-33(42)41-30-7-2-1-6-28(30)37/h1-18,20H,19,37H2,(H,41,42)(H,38,39,40)/b15-11+ IBUAKKIEDFKTKJ-RVDMUPIBSA-N 50332486 CHEMBL1630113::N-(2-aminophenyl)-3-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)furan-2-yl)acrylamide Serine/threonine-protein kinase PLK1 Homo sapiens 8500 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332486&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855761 125082588 CHEMBL1630113 ZINC66251391 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612502 Nc1ccccc1NC(=O)\C=C\c1cccc(c1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C36H27ClFN5O2/c37-30-20-28(13-15-34(30)45-21-24-6-4-8-27(38)18-24)42-36-29-19-26(12-14-32(29)40-22-41-36)25-7-3-5-23(17-25)11-16-35(44)43-33-10-2-1-9-31(33)39/h1-20,22H,21,39H2,(H,43,44)(H,40,41,42)/b16-11+ OZWPBBYNOKRDFB-LFIBNONCSA-N 50332487 (E)-N-(2-aminophenyl)-3-(3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide::CHEMBL1630114 Serine/threonine-protein kinase PLK1 Homo sapiens 5500 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332487&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855949 125082589 CHEMBL1630114 ZINC66251586 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612503 Nc1ccccc1NC(=O)\C=C\c1ccc(cc1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C36H27ClFN5O2/c37-30-20-28(14-16-34(30)45-21-24-4-3-5-27(38)18-24)42-36-29-19-26(13-15-32(29)40-22-41-36)25-11-8-23(9-12-25)10-17-35(44)43-33-7-2-1-6-31(33)39/h1-20,22H,21,39H2,(H,43,44)(H,40,41,42)/b17-10+ NREXZVOJRVRMAI-LICLKQGHSA-N 50332488 (E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide::CHEMBL1630115 Serine/threonine-protein kinase PLK1 Homo sapiens 6200 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332488&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855950 125082590 CHEMBL1630115 ZINC66251587 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612504 Nc1ccccc1NC(=O)CCc1ccc(cc1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C36H29ClFN5O2/c37-30-20-28(14-16-34(30)45-21-24-4-3-5-27(38)18-24)42-36-29-19-26(13-15-32(29)40-22-41-36)25-11-8-23(9-12-25)10-17-35(44)43-33-7-2-1-6-31(33)39/h1-9,11-16,18-20,22H,10,17,21,39H2,(H,43,44)(H,40,41,42) WYZOMYWEQQWFAG-UHFFFAOYSA-N 50332489 CHEMBL1630116::N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide Serine/threonine-protein kinase PLK1 Homo sapiens 27000 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332489&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855951 125082591 CHEMBL1630116 ZINC66251222 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612505 ONC(=O)c1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C26H18ClFN4O4/c27-20-12-18(5-7-23(20)35-13-15-2-1-3-17(28)10-15)31-25-19-11-16(4-6-21(19)29-14-30-25)22-8-9-24(36-22)26(33)32-34/h1-12,14,34H,13H2,(H,32,33)(H,29,30,31) ZMYUKKKHJVNBAM-UHFFFAOYSA-N 50332490 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)-N-hydroxyfuran-2-carboxamide::CHEMBL1630117 Serine/threonine-protein kinase PLK1 Homo sapiens 2000 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332490&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855952 125082592 CHEMBL1630117 ZINC66251223 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50612506 ONC(=O)c1ccc(s1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C26H18ClFN4O3S/c27-20-12-18(5-7-22(20)35-13-15-2-1-3-17(28)10-15)31-25-19-11-16(4-6-21(19)29-14-30-25)23-8-9-24(36-23)26(33)32-34/h1-12,14,34H,13H2,(H,32,33)(H,29,30,31) DNZYOZKYEXTOPJ-UHFFFAOYSA-N 50332493 5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)-N-hydroxythiophene-2-carboxamide::CHEMBL1630118 Serine/threonine-protein kinase PLK1 Homo sapiens 2900 ChEMBL 10.1021/jm100665z 10.7270/Q2J38STX 21080629 Mahboobi, S; Sellmer, A; Winkler, M; Eichhorn, E; Pongratz, H; Ciossek, T; Baer, T; Maier, T; Beckers, T University of Regensburg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332493&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49855953 125082595 CHEMBL1630118 ZINC66262289 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50609890 COc1ccc2cc([nH]c2c1)-c1n[nH]c2cccnc12 InChI=1S/C15H12N4O/c1-20-10-5-4-9-7-13(17-12(9)8-10)15-14-11(18-19-15)3-2-6-16-14/h2-8,17H,1H3,(H,18,19) PRASIGARSOSUQT-UHFFFAOYSA-N 50331277 3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyridine::CHEMBL1288582 Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2010.09.119 10.7270/Q2JD4X29 20965724 Herdemann, M; Heit, I; Bosch, FU; Quintini, G; Scheipers, C; Weber, A Nycomed GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331277&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49839480 123110392 CHEMBL1288582 ZINC64548888 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639204 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31) QHLVBNKYJGBCQJ-UHFFFAOYSA-N 50343559 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE::1-(2-hydroxyethyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1738758 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343559&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 937 2YAC 49792852 131346495 CHEMBL1738758 ZINC43196885 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639205 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCN)c4-c3n2)C(N)=O)c1 InChI=1S/C24H28F3N9O2/c1-34-8-10-35(11-9-34)15-3-5-18(38-24(25,26)27)17(12-15)31-23-30-13-14-2-4-16-20(22(29)37)33-36(7-6-28)21(16)19(14)32-23/h3,5,12-13H,2,4,6-11,28H2,1H3,(H2,29,37)(H,30,31,32) FNVWTCCOPVJPNB-UHFFFAOYSA-N 50343560 1-(2-aminoethyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774337 Serine/threonine-protein kinase PLK1 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343560&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54587248 131346496 CHEMBL1774337 ZINC71317900 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639206 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCOC5CCOCC5)c4-c3n2)C(N)=O)c1 InChI=1S/C29H35F3N8O4/c1-38-8-10-39(11-9-38)19-3-5-23(44-29(30,31)32)22(16-19)35-28-34-17-18-2-4-21-25(27(33)41)37-40(26(21)24(18)36-28)12-15-43-20-6-13-42-14-7-20/h3,5,16-17,20H,2,4,6-15H2,1H3,(H2,33,41)(H,34,35,36) UPPBHPLFAHWJFR-UHFFFAOYSA-N 50343561 8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-(2-(tetrahydro-2H-pyran-4-yloxy)ethyl)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774338 Serine/threonine-protein kinase PLK1 Homo sapiens 43 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343561&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54586220 131346497 CHEMBL1774338 ZINC71329793 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639207 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCCN)c4-c3n2)C(N)=O)c1 InChI=1S/C25H30F3N9O2/c1-35-9-11-36(12-10-35)16-4-6-19(39-25(26,27)28)18(13-16)32-24-31-14-15-3-5-17-21(23(30)38)34-37(8-2-7-29)22(17)20(15)33-24/h4,6,13-14H,2-3,5,7-12,29H2,1H3,(H2,30,38)(H,31,32,33) YALDCBLTYPJUTR-UHFFFAOYSA-N 50343562 1-(3-aminopropyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774339 Serine/threonine-protein kinase PLK1 Homo sapiens 52 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343562&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54580351 131346498 CHEMBL1774339 ZINC71317885 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639208 CN(C)CCCn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 InChI=1S/C27H34F3N9O2/c1-36(2)9-4-10-39-24-19(23(35-39)25(31)40)7-5-17-16-32-26(34-22(17)24)33-20-15-18(38-13-11-37(3)12-14-38)6-8-21(20)41-27(28,29)30/h6,8,15-16H,4-5,7,9-14H2,1-3H3,(H2,31,40)(H,32,33,34) JFSOUEUFOCRRAX-UHFFFAOYSA-N 50343563 1-(3-(dimethylamino)propyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774340 Serine/threonine-protein kinase PLK1 Homo sapiens 279 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343563&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54582374 131346499 CHEMBL1774340 ZINC71319424 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639294 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C23H25F3N8O2/c1-32-7-9-34(10-8-32)14-4-6-17(36-23(24,25)26)16(11-14)29-22-28-12-13-3-5-15-19(21(27)35)31-33(2)20(15)18(13)30-22/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,27,35)(H,28,29,30) VEFDUZNTHFBSFU-UHFFFAOYSA-N 50329914 1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272140 Serine/threonine-protein kinase PLK1 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24825755 123109029 CHEMBL1272140 ZINC43196882 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639295 CN1CCC(=CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H24F3N7O2/c1-33-9-7-13(8-10-33)14-4-6-18(36-24(25,26)27)17(11-14)30-23-29-12-15-3-5-16-20(22(28)35)32-34(2)21(16)19(15)31-23/h4,6-7,11-12H,3,5,8-10H2,1-2H3,(H2,28,35)(H,29,30,31) DFKJNGVBNCASDM-UHFFFAOYSA-N 50343568 1-methyl-8-(5-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774327 Serine/threonine-protein kinase PLK1 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343568&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54585267 131346504 CHEMBL1774327 ZINC71296607 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639296 CN1CCC(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(cn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C25H27F3N6O2/c1-33-9-7-14(8-10-33)15-4-6-20(36-25(26,27)28)19(11-15)31-24-30-12-16-3-5-17-18(23(29)35)13-34(2)22(17)21(16)32-24/h4,6,11-14H,3,5,7-10H2,1-2H3,(H2,29,35)(H,30,31,32) UPGSUYGNMGTTGT-UHFFFAOYSA-N 50343569 9-methyl-2-(5-(1-methylpiperidin-4-yl)-2-(trifluoromethoxy)phenylamino)-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline-7-carboxamide::CHEMBL1774328 Serine/threonine-protein kinase PLK1 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343569&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54582373 131346505 CHEMBL1774328 ZINC71297068 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639297 CN(C)CCCN1CCC(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C28H35F3N8O2/c1-37(2)11-4-12-39-13-9-17(10-14-39)18-6-8-22(41-28(29,30)31)21(15-18)34-27-33-16-19-5-7-20-24(26(32)40)36-38(3)25(20)23(19)35-27/h6,8,15-17H,4-5,7,9-14H2,1-3H3,(H2,32,40)(H,33,34,35) HNIOCCUDARXKTR-UHFFFAOYSA-N 50343570 8-(5-(1-(3-(dimethylamino)propyl)piperidin-4-yl)-2-(trifluoromethoxy)phenylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774329 Serine/threonine-protein kinase PLK1 Homo sapiens 42 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343570&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54583357 131346506 CHEMBL1774329 ZINC71317162 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639298 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(NC(=O)[C@@H]5CCCN5)ccc4OC(F)(F)F)nc3-c12 InChI=1S/C23H23F3N8O3/c1-34-19-13(18(33-34)20(27)35)6-4-11-10-29-22(32-17(11)19)31-15-9-12(5-7-16(15)37-23(24,25)26)30-21(36)14-3-2-8-28-14/h5,7,9-10,14,28H,2-4,6,8H2,1H3,(H2,27,35)(H,30,36)(H,29,31,32)/t14-/m0/s1 YRUKXDLUMKDTLG-AWEZNQCLSA-N 50343571 (S)-1-methyl-8-(5-(pyrrolidine-2-carboxamido)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774330 Serine/threonine-protein kinase PLK1 Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343571&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54584304 131346507 CHEMBL1774330 ZINC71316469 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639299 CCN(CC)CCN(C)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C25H31F3N8O2/c1-5-36(6-2)12-11-34(3)16-8-10-19(38-25(26,27)28)18(13-16)31-24-30-14-15-7-9-17-21(23(29)37)33-35(4)22(17)20(15)32-24/h8,10,13-14H,5-7,9,11-12H2,1-4H3,(H2,29,37)(H,30,31,32) PCGFAESANBCIRP-UHFFFAOYSA-N 50343564 8-(5-((2-(diethylamino)ethyl)(methyl)amino)-2-(trifluoromethoxy)phenylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774331 Serine/threonine-protein kinase PLK1 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343564&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54585268 131346500 CHEMBL1774331 ZINC71319068 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639300 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(NC5CCCN5)ccc4OC(F)(F)F)nc3-c12 InChI=1S/C22H23F3N8O2/c1-33-19-13(18(32-33)20(26)34)6-4-11-10-28-21(31-17(11)19)30-14-9-12(29-16-3-2-8-27-16)5-7-15(14)35-22(23,24)25/h5,7,9-10,16,27,29H,2-4,6,8H2,1H3,(H2,26,34)(H,28,30,31) SPFHEVHMQYYTHW-UHFFFAOYSA-N 50343565 1-methyl-8-(5-(pyrrolidin-2-ylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774332 Serine/threonine-protein kinase PLK1 Homo sapiens 83 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343565&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54584305 131346501 CHEMBL1774332 ZINC71317846 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639301 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(N)ccc4OC(F)(F)F)nc3-c12 InChI=1S/C18H16F3N7O2/c1-28-15-10(14(27-28)16(23)29)4-2-8-7-24-17(26-13(8)15)25-11-6-9(22)3-5-12(11)30-18(19,20)21/h3,5-7H,2,4,22H2,1H3,(H2,23,29)(H,24,25,26) NCDFJOWBEBTLBV-UHFFFAOYSA-N 50329931 8-(5-amino-2-(trifluoromethoxy)phenylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1269042 Serine/threonine-protein kinase PLK1 Homo sapiens 87 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52943186 123109046 CHEMBL1269042 ZINC64526467 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639302 CN1CCN(CCCNc2ccc(OC(F)(F)F)c(Nc3ncc4CCc5c(nn(C)c5-c4n3)C(N)=O)c2)CC1 InChI=1S/C26H32F3N9O2/c1-36-10-12-38(13-11-36)9-3-8-31-17-5-7-20(40-26(27,28)29)19(14-17)33-25-32-15-16-4-6-18-22(24(30)39)35-37(2)23(18)21(16)34-25/h5,7,14-15,31H,3-4,6,8-13H2,1-2H3,(H2,30,39)(H,32,33,34) YMKBQPSSBXLIRY-UHFFFAOYSA-N 50343566 1-methyl-8-(5-(3-(4-methylpiperazin-1-yl)propylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774333 Serine/threonine-protein kinase PLK1 Homo sapiens 106 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343566&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54585269 131346502 CHEMBL1774333 ZINC71318348 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639303 CN1CCCC1CCNc1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C25H29F3N8O2/c1-35-11-3-4-16(35)9-10-30-15-6-8-19(38-25(26,27)28)18(12-15)32-24-31-13-14-5-7-17-21(23(29)37)34-36(2)22(17)20(14)33-24/h6,8,12-13,16,30H,3-5,7,9-11H2,1-2H3,(H2,29,37)(H,31,32,33) JVZPJOJXJIONKU-UHFFFAOYSA-N 50329935 1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271535 Serine/threonine-protein kinase PLK1 Homo sapiens 149 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329935&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52946971 123109050 CHEMBL1271535 ZINC64526301 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639304 CN1CCN([C@@H](CO)C1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O3/c1-33-7-8-35(15(11-33)12-36)14-4-6-18(38-24(25,26)27)17(9-14)30-23-29-10-13-3-5-16-20(22(28)37)32-34(2)21(16)19(13)31-23/h4,6,9-10,15,36H,3,5,7-8,11-12H2,1-2H3,(H2,28,37)(H,29,30,31)/t15-/m1/s1 VCZOROQVTTWAJY-OAHLLOKOSA-N 50343567 (R)-8-(5-(2-(hydroxymethyl)-4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774334 Serine/threonine-protein kinase PLK1 Homo sapiens 154 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343567&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54581348 131346503 CHEMBL1774334 ZINC71318312 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639305 CN1CCN([C@H](CO)C1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O3/c1-33-7-8-35(15(11-33)12-36)14-4-6-18(38-24(25,26)27)17(9-14)30-23-29-10-13-3-5-16-20(22(28)37)32-34(2)21(16)19(13)31-23/h4,6,9-10,15,36H,3,5,7-8,11-12H2,1-2H3,(H2,28,37)(H,29,30,31)/t15-/m0/s1 VCZOROQVTTWAJY-HNNXBMFYSA-N 50343557 (S)-8-(5-(2-(hydroxymethyl)-4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774335 Serine/threonine-protein kinase PLK1 Homo sapiens 201 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343557&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54583358 131346493 CHEMBL1774335 ZINC71329387 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50639306 CN1CCC(CC1)C(=O)Nc1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C25H27F3N8O3/c1-35-9-7-13(8-10-35)23(38)31-15-4-6-18(39-25(26,27)28)17(11-15)32-24-30-12-14-3-5-16-20(22(29)37)34-36(2)21(16)19(14)33-24/h4,6,11-13H,3,5,7-10H2,1-2H3,(H2,29,37)(H,31,38)(H,30,32,33) KMZDOKNRRSNTSW-UHFFFAOYSA-N 50343558 1-methyl-8-(5-(1-methylpiperidine-4-carboxamido)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1774336 Serine/threonine-protein kinase PLK1 Homo sapiens 224 ChEMBL 10.1016/j.bmcl.2011.03.054 10.7270/Q27M088W 21470862 Beria, I; Bossi, RT; Brasca, MG; Caruso, M; Ceccarelli, W; Fachin, G; Fasolini, M; Forte, B; Fiorentini, F; Pesenti, E; Pezzetta, D; Posteri, H; Scolaro, A; Re Depaolini, S; Valsasina, B Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343558&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54583359 131346494 CHEMBL1774336 ZINC71296682 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50648403 CCc1nc(C)c(C=C2C(=O)Nc3ccc(NC(=O)C#C)cc23)[nH]1 InChI=1S/C18H16N4O2/c1-4-16-19-10(3)15(21-16)9-13-12-8-11(20-17(23)5-2)6-7-14(12)22-18(13)24/h2,6-9H,4H2,1,3H3,(H,19,21)(H,20,23)(H,22,24) ORKOHXAJFGRZCL-UHFFFAOYSA-N 50347863 CHEMBL1802870 Serine/threonine-protein kinase PLK1 Homo sapiens >20000 ChEMBL 10.1021/jm200222m 10.7270/Q2QC03TX 21627121 Henise, JC; Taunton, J University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347863&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53262909 136354549 CHEMBL1802870 ZINC72108869 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629708 CN1CCC(CC1)Oc1ccc2ncn(-c3cc(OCc4ccccc4)c(s3)C(N)=O)c2c1 InChI=1S/C25H26N4O3S/c1-28-11-9-18(10-12-28)32-19-7-8-20-21(13-19)29(16-27-20)23-14-22(24(33-23)25(26)30)31-15-17-5-3-2-4-6-17/h2-8,13-14,16,18H,9-12,15H2,1H3,(H2,26,30) GVKBBYXGXQFMBY-UHFFFAOYSA-N 50339793 3-(benzyloxy)-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1689159 Serine/threonine-protein kinase PLK1 Homo sapiens 69 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339793&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51355153 125089895 CHEMBL1689159 ZINC66124022 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629709 CC(Oc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12)c1ccccc1 InChI=1S/C26H28N4O3S/c1-17(18-6-4-3-5-7-18)32-23-15-24(34-25(23)26(27)31)30-16-28-21-9-8-20(14-22(21)30)33-19-10-12-29(2)13-11-19/h3-9,14-17,19H,10-13H2,1-2H3,(H2,27,31) YNOAKGVICFPGBG-UHFFFAOYSA-N 50339794 (+/-)-5-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-3-(1-phenylethoxy)thiophene-2-carboxamide::CHEMBL1689160 Serine/threonine-protein kinase PLK1 Homo sapiens 66 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339794&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51355154 125089896 CHEMBL1689160 ZINC66124025 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629710 COc1cc(sc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12 InChI=1S/C19H22N4O3S/c1-22-7-5-12(6-8-22)26-13-3-4-14-15(9-13)23(11-21-14)17-10-16(25-2)18(27-17)19(20)24/h3-4,9-12H,5-8H2,1-2H3,(H2,20,24) VHRWFKCDPVKNGE-UHFFFAOYSA-N 50339796 3-Methoxy-5-(6-(1-methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide::CHEMBL1689161 Serine/threonine-protein kinase PLK1 Homo sapiens 1330 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339796&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51355155 125089898 CHEMBL1689161 ZINC66104964 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629711 COc1cc(sc1C(N)=O)-n1cnc2ccccc12 InChI=1S/C13H11N3O2S/c1-18-10-6-11(19-12(10)13(14)17)16-7-15-8-4-2-3-5-9(8)16/h2-7H,1H3,(H2,14,17) KEUXAQBCBLZTJR-UHFFFAOYSA-N 50339797 5-(1H-Benzo[d]imidazol-1-yl)-3-methoxythiophene-2-carboxamide::CHEMBL1689162 Serine/threonine-protein kinase PLK1 Homo sapiens 5310 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339797&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51355435 125089899 CHEMBL1689162 ZINC66114299 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629712 CC(Oc1cc(ccc1C(N)=O)-n1cnc2ccc(OC3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C29H29F3N4O3/c1-18(22-5-3-4-6-24(22)29(30,31)32)38-27-15-19(7-9-23(27)28(33)37)36-17-34-25-10-8-21(16-26(25)36)39-20-11-13-35(2)14-12-20/h3-10,15-18,20H,11-14H2,1-2H3,(H2,33,37) BNJAETMQKIKKSN-UHFFFAOYSA-N 50339799 (+/-)-4-(6-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide::CHEMBL1689164 Serine/threonine-protein kinase PLK1 Homo sapiens 190 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339799&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51357926 125089901 CHEMBL1689164 ZINC66104969 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629713 CC(Oc1cc(ccc1C(N)=O)-n1cnc2cc(OC3CCN(C)CC3)ccc12)c1ccccc1C(F)(F)F InChI=1S/C29H29F3N4O3/c1-18(22-5-3-4-6-24(22)29(30,31)32)38-27-15-19(7-9-23(27)28(33)37)36-17-34-25-16-21(8-10-26(25)36)39-20-11-13-35(2)14-12-20/h3-10,15-18,20H,11-14H2,1-2H3,(H2,33,37) FASALJZFFLCNKM-UHFFFAOYSA-N 50339800 (+/-)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide::CHEMBL1689165 Serine/threonine-protein kinase PLK1 Homo sapiens 87900 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339800&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search WCX 2XNP 51355713 125089902 CHEMBL1689165 ZINC66112154 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629714 C[C@@H](Oc1cc(ccc1C(N)=O)-n1cnc2cc(OC3CCN(C)CC3)ccc12)c1ccccc1C(F)(F)F InChI=1S/C29H29F3N4O3/c1-18(22-5-3-4-6-24(22)29(30,31)32)38-27-15-19(7-9-23(27)28(33)37)36-17-34-25-16-21(8-10-26(25)36)39-20-11-13-35(2)14-12-20/h3-10,15-18,20H,11-14H2,1-2H3,(H2,33,37)/t18-/m1/s1 FASALJZFFLCNKM-GOSISDBHSA-N 50339801 (R)-4-(5-(1-Methylpiperidin-4-yloxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide::4-{5-[(1-METHYLPIPERIDIN-4-YL)OXY]-1H-BENZIMIDAZOL-1-YL}-2-{(1R)-1-[2-(TRIFLUOROMETHYL)PHENYL]ETHOXY}BENZAMIDE::CHEMBL1615277 Serine/threonine-protein kinase PLK1 Homo sapiens 51300 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339801&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search WCX 2XNP 50990894 125089903 CHEMBL1615277 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50629715 CC(Oc1cc(ccc1C(N)=O)-n1cnc2cc(OCCCN(C)C)ccc12)c1ccccc1C(F)(F)F InChI=1S/C28H29F3N4O3/c1-18(21-7-4-5-8-23(21)28(29,30)31)38-26-15-19(9-11-22(26)27(32)36)35-17-33-24-16-20(10-12-25(24)35)37-14-6-13-34(2)3/h4-5,7-12,15-18H,6,13-14H2,1-3H3,(H2,32,36) OEVZUXKNDLGAKU-UHFFFAOYSA-N 50339803 (+/-)-4-(5-(3-(Dimethylamino)propoxy)-1H-benzo[d]imidazol-1-yl)-2-(1-(2-(trifluoromethyl)phenyl)ethoxy)benzamide::CHEMBL1689168 Serine/threonine-protein kinase PLK1 Homo sapiens 15200 ChEMBL 10.1021/jm1011726 10.7270/Q2057G7X 21366329 Solanki, S; Innocenti, P; Mas-Droux, C; Boxall, K; Barillari, C; van Montfort, RL; Aherne, GW; Bayliss, R; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339803&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 51355977 125089905 CHEMBL1689168 ZINC66114308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50668086 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50665591 CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) QADPYRIHXKWUSV-UHFFFAOYSA-N 50355393 BGJ398::CHEMBL1834657::US9434697, BGJ398::US9730931, BGJ398 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm2006222 10.7270/Q22N52N1 21936542 Guagnano, V; Furet, P; Spanka, C; Bordas, V; Le Douget, M; Stamm, C; Brueggen, J; Jensen, MR; Schnell, C; Schmid, H; Wartmann, M; Berghausen, J; Drueckes, P; Zimmerlin, A; Bussiere, D; Murray, J; Graus Porta, D Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355393&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 07J 3TT0 53235510 136362079 CHEMBL1834657 ZINC72105034 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50652584 CSCC[C@H](NC(=O)c1ccc2C(=O)OC3(c2c1)c1ccc(O)cc1Oc1cc(O)ccc31)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(O)=O InChI=1S/C49H60N7O19PS/c1-23(2)18-34(47(67)68)53-45(65)36-6-5-16-56(36)46(66)40(24(3)75-76(70,71)72)55-44(64)35(22-57)54-42(62)32(13-14-39(50)60)52-43(63)33(15-17-77-4)51-41(61)25-7-10-28-31(19-25)49(74-48(28)69)29-11-8-26(58)20-37(29)73-38-21-27(59)9-12-30(38)49/h7-12,19-21,23-24,32-36,40,57-59H,5-6,13-18,22H2,1-4H3,(H2,50,60)(H,51,61)(H,52,63)(H,53,65)(H,54,62)(H,55,64)(H,67,68)(H2,70,71,72)/t24-,32+,33+,34+,35+,36+,40+/m1/s1 CSNLLTCSCRKMKI-SEVDSDJXSA-N 50349791 CHEMBL1809230 Serine/threonine-protein kinase PLK1 Homo sapiens 93 ChEMBL 10.1016/j.bmcl.2011.06.103 10.7270/Q2BP034N 21778054 Richter, S; Neundorf, I; Loebner, K; Graber, M; Berg, T; Bergmann, R; Steinbach, J; Pietzsch, J; Wuest, F Helmholtz Center Dresden-Rossendorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349791&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56659846 136356477 CHEMBL1809230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50652585 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)c1ccc2C(=O)OC3(c2c1)c1ccc(O)cc1Oc1cc(O)ccc31)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(N)=O InChI=1S/C141H227N42O37PS/c1-11-77(8)112(134(212)175-90(35-18-23-56-145)118(196)174-97(49-51-111(190)191)124(202)164-87(114(149)192)32-15-20-53-142)181-127(205)91(36-19-24-57-146)169-131(209)103(71-109(148)188)178-123(201)95(40-28-61-161-140(156)157)172-130(208)102(67-79-30-13-12-14-31-79)177-121(199)89(34-17-22-55-144)167-120(198)93(38-26-59-159-138(152)153)171-129(207)101(66-76(6)7)176-122(200)94(39-27-60-160-139(154)155)168-117(195)88(33-16-21-54-143)166-119(197)92(37-25-58-158-137(150)151)170-128(206)100(65-75(4)5)163-110(189)72-162-116(194)99(64-74(2)3)179-133(211)105-41-29-62-183(105)135(213)113(78(9)220-221(215,216)217)182-132(210)104(73-184)180-125(203)96(48-50-108(147)187)173-126(204)98(52-63-222-10)165-115(193)80-42-45-83-86(68-80)141(219-136(83)214)84-46-43-81(185)69-106(84)218-107-70-82(186)44-47-85(107)141/h12-14,30-31,42-47,68-70,74-78,87-105,112-113,184-186H,11,15-29,32-41,48-67,71-73,142-146H2,1-10H3,(H2,147,187)(H2,148,188)(H2,149,192)(H,162,194)(H,163,189)(H,164,202)(H,165,193)(H,166,197)(H,167,198)(H,168,195)(H,169,209)(H,170,206)(H,171,207)(H,172,208)(H,173,204)(H,174,196)(H,175,212)(H,176,200)(H,177,199)(H,178,201)(H,179,211)(H,180,203)(H,181,205)(H,182,210)(H,190,191)(H4,150,151,158)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)(H2,215,216,217)/t77-,78+,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,112-,113-/m0/s1 FUGMSFVJNSDLQF-HFUUFOHKSA-N 50349792 CHEMBL1809231 Serine/threonine-protein kinase PLK1 Homo sapiens 256 ChEMBL 10.1016/j.bmcl.2011.06.103 10.7270/Q2BP034N 21778054 Richter, S; Neundorf, I; Loebner, K; Graber, M; Berg, T; Bergmann, R; Steinbach, J; Pietzsch, J; Wuest, F Helmholtz Center Dresden-Rossendorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349792&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91930694 136356478 CHEMBL1809231 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50652586 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)c1ccc2C(=O)OC3(c2c1)c1ccc(O)cc1Oc1cc(O)ccc31)[C@@H](C)OP(O)(O)=O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(N)=O InChI=1S/C197H304N53O49PS/c1-15-108(6)157(187(286)218-103-155(259)242-156(107(4)5)186(285)217-102-154(258)220-111(9)190(289)247-88-43-63-146(247)161(208)260)243-163(262)110(8)222-188(287)158(113(11)252)244-177(276)138(74-76-153(207)257)235-184(283)148-65-45-90-249(148)192(291)144(96-118-51-23-18-24-52-118)240-189(288)159(114(12)253)245-181(280)143(98-120-101-213-105-219-120)238-180(279)142(95-117-49-21-17-22-50-117)237-174(273)133(232-179(278)140(93-106(2)3)239-185(284)149-66-46-91-250(149)193(292)160(115(13)299-300(294,295)296)246-182(281)145(104-251)241-175(274)137(73-75-152(206)256)233-176(275)139(77-92-301-14)224-164(263)119-67-70-123-126(97-119)197(298-194(123)293)124-71-68-121(254)99-150(124)297-151-100-122(255)69-72-125(151)197)60-32-40-85-214-162(261)109(7)221-178(277)141(94-116-47-19-16-20-48-116)236-173(272)132(58-30-38-83-203)229-172(271)136(62-42-87-216-196(211)212)231-169(268)131(57-29-37-82-202)227-168(267)130(56-28-36-81-201)228-170(269)134(59-31-39-84-204)234-183(282)147-64-44-89-248(147)191(290)112(10)223-166(265)128(54-26-34-79-199)226-171(270)135(61-41-86-215-195(209)210)230-167(266)129(55-27-35-80-200)225-165(264)127(205)53-25-33-78-198/h16-24,47-52,67-72,97,99-101,105-115,127-149,156-160,251-255H,15,25-46,53-66,73-96,98,102-104,198-205H2,1-14H3,(H2,206,256)(H2,207,257)(H2,208,260)(H,213,219)(H,214,261)(H,217,285)(H,218,286)(H,220,258)(H,221,277)(H,222,287)(H,223,265)(H,224,263)(H,225,264)(H,226,270)(H,227,267)(H,228,269)(H,229,271)(H,230,266)(H,231,268)(H,232,278)(H,233,275)(H,234,282)(H,235,283)(H,236,272)(H,237,273)(H,238,279)(H,239,284)(H,240,288)(H,241,274)(H,242,259)(H,243,262)(H,244,276)(H,245,280)(H,246,281)(H4,209,210,215)(H4,211,212,216)(H2,294,295,296)/t108-,109-,110-,111-,112-,113+,114+,115+,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,156-,157-,158-,159-,160-/m0/s1 ABVRDLWLESUJPR-NMOXAQNZSA-N 50349793 CHEMBL1809232 Serine/threonine-protein kinase PLK1 Homo sapiens 326 ChEMBL 10.1016/j.bmcl.2011.06.103 10.7270/Q2BP034N 21778054 Richter, S; Neundorf, I; Loebner, K; Graber, M; Berg, T; Bergmann, R; Steinbach, J; Pietzsch, J; Wuest, F Helmholtz Center Dresden-Rossendorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349793&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91930695 136356479 CHEMBL1809232 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50668394 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Serine/threonine-protein kinase PLK1 Homo sapiens 830 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50668664 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50654317 Cc1cc(O)cc2oc3cc(O)cc(O)c3c(=O)c12 InChI=1S/C14H10O5/c1-6-2-7(15)4-10-12(6)14(18)13-9(17)3-8(16)5-11(13)19-10/h2-5,15-17H,1H3 AQZHBCDRWFMXIN-UHFFFAOYSA-N 50350423 CHEMBL466154 Serine/threonine-protein kinase PLK1 Homo sapiens 75700 ChEMBL 10.1016/j.bmc.2011.06.013 10.7270/Q2X92BNH 21741249 Ebada, SS; Schulz, B; Wray, V; Totzke, F; Kubbutat, MH; Muller, WE; Hamacher, A; Kassack, MU; Lin, W; Proksch, P Heinrich Heine Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350423&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5281657 136357109 CHEMBL466154 C10087 ZINC05765089 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50654318 Cc1c(O)c(O)cc2oc3cc(O)cc(O)c3c(=O)c12 InChI=1S/C14H10O6/c1-5-11-10(4-8(17)13(5)18)20-9-3-6(15)2-7(16)12(9)14(11)19/h2-4,15-18H,1H3 YPBXGIBBOZOVPM-UHFFFAOYSA-N 50350424 CHEMBL454440 Serine/threonine-protein kinase PLK1 Homo sapiens 8800 ChEMBL 10.1016/j.bmc.2011.06.013 10.7270/Q2X92BNH 21741249 Ebada, SS; Schulz, B; Wray, V; Totzke, F; Kubbutat, MH; Muller, WE; Hamacher, A; Kassack, MU; Lin, W; Proksch, P Heinrich Heine Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50350424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50350424&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10423452 136357110 CHEMBL454440 ZINC14761282 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50667404 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50667541 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50667722 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651169 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(=O)N3CCC[C@H]3CN3CCCC3)nc-21 InChI=1S/C38H46N8O3/c1-5-24-11-9-12-25(6-2)32(24)41-36(47)34-29-16-14-27-22-39-38(42-33(27)35(29)44(3)43-34)40-30-17-15-26(21-31(30)49-4)37(48)46-20-10-13-28(46)23-45-18-7-8-19-45/h9,11-12,15,17,21-22,28H,5-8,10,13-14,16,18-20,23H2,1-4H3,(H,41,47)(H,39,40,42)/t28-/m0/s1 LTKUHPWNVCRTSA-NDEPHWFRSA-N 50349090 CHEMBL1807301 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349090&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44555518 136355776 CHEMBL1807301 ZINC72176312 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651170 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)N3CCC[C@H]3CN3CCCC3)nc-21 InChI=1S/C38H43F3N8O3/c1-4-23-10-8-11-24(5-2)31(23)44-35(50)33-28-15-13-26-21-42-37(45-32(26)34(28)47(3)46-33)43-29-16-14-25(20-30(29)52-38(39,40)41)36(51)49-19-9-12-27(49)22-48-17-6-7-18-48/h8,10-11,14,16,20-21,27H,4-7,9,12-13,15,17-19,22H2,1-3H3,(H,44,50)(H,42,43,45)/t27-/m0/s1 WZZWJWWPQJVGAJ-MHZLTWQESA-N 50349091 CHEMBL1807302 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349091&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56676891 136355777 CHEMBL1807302 ZINC72176394 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651171 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(=O)N3CCC(CC3)N(C)C)nc-21 InChI=1S/C36H44N8O3/c1-7-22-10-9-11-23(8-2)30(22)39-34(45)32-27-14-12-25-21-37-36(40-31(25)33(27)43(5)41-32)38-28-15-13-24(20-29(28)47-6)35(46)44-18-16-26(17-19-44)42(3)4/h9-11,13,15,20-21,26H,7-8,12,14,16-19H2,1-6H3,(H,39,45)(H,37,38,40) COJCXGYVLBGQIH-UHFFFAOYSA-N 50349092 CHEMBL1807303 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349092&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44555517 136355778 CHEMBL1807303 ZINC72178757 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651172 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)N3CCC(CC3)N(C)C)nc-21 InChI=1S/C36H41F3N8O3/c1-6-21-9-8-10-22(7-2)29(21)42-33(48)31-26-13-11-24-20-40-35(43-30(24)32(26)46(5)44-31)41-27-14-12-23(19-28(27)50-36(37,38)39)34(49)47-17-15-25(16-18-47)45(3)4/h8-10,12,14,19-20,25H,6-7,11,13,15-18H2,1-5H3,(H,42,48)(H,40,41,43) MWTWLPODPMOIIN-UHFFFAOYSA-N 50349093 CHEMBL1807304 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56663194 136355779 CHEMBL1807304 ZINC72139821 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651173 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(=O)N3CCCN(C)CC3)nc-21 InChI=1S/C35H42N8O3/c1-6-22-10-8-11-23(7-2)29(22)38-33(44)31-26-14-12-25-21-36-35(39-30(25)32(26)42(4)40-31)37-27-15-13-24(20-28(27)46-5)34(45)43-17-9-16-41(3)18-19-43/h8,10-11,13,15,20-21H,6-7,9,12,14,16-19H2,1-5H3,(H,38,44)(H,36,37,39) JRZGFHZNTXYGPL-UHFFFAOYSA-N 50349094 CHEMBL1807305 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349094&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44555820 136355780 CHEMBL1807305 ZINC72178666 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651174 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)N3CCCN(C)CC3)nc-21 InChI=1S/C35H39F3N8O3/c1-5-21-9-7-10-22(6-2)28(21)41-32(47)30-25-13-11-24-20-39-34(42-29(24)31(25)45(4)43-30)40-26-14-12-23(19-27(26)49-35(36,37)38)33(48)46-16-8-15-44(3)17-18-46/h7,9-10,12,14,19-20H,5-6,8,11,13,15-18H2,1-4H3,(H,41,47)(H,39,40,42) LTJCDVIZSPUSDR-UHFFFAOYSA-N 50349095 CHEMBL1807306 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53363389 136355781 CHEMBL1807306 ZINC72179724 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651222 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C17H16N6O/c1-23-15-12(14(22-23)16(18)24)8-7-10-9-19-17(21-13(10)15)20-11-5-3-2-4-6-11/h2-6,9H,7-8H2,1H3,(H2,18,24)(H,19,20,21) UTHWBIPHRYUJSU-UHFFFAOYSA-N 31532 pyrazolo[4,3-h]quinazoline-3-carboxamide, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 68 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31532&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44236351 172097433 ZINC42201314 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651223 Cc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H18N6O/c1-10-5-3-4-6-13(10)21-18-20-9-11-7-8-12-15(17(19)25)23-24(2)16(12)14(11)22-18/h3-6,9H,7-8H2,1-2H3,(H2,19,25)(H,20,21,22) OXPLZKSKLWBEIM-UHFFFAOYSA-N 50318085 1-Methyl-8-[(2-methylphenyl)amino]-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094477 Serine/threonine-protein kinase PLK1 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24992861 104152446 CHEMBL1094477 ZINC49072889 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651224 COc1ccccc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O InChI=1S/C18H18N6O2/c1-24-16-11(15(23-24)17(19)25)8-7-10-9-20-18(22-14(10)16)21-12-5-3-4-6-13(12)26-2/h3-6,9H,7-8H2,1-2H3,(H2,19,25)(H,20,21,22) XEMJTISGDXHELX-UHFFFAOYSA-N 50318081 8-[(2-Methoxyphenyl)amino]-1-methyl-4,5-dihydro-1H-pyrazolo-[4,3-h]quinazoline-3-carboxamide::CHEMBL1094135 Serine/threonine-protein kinase PLK1 Homo sapiens 42 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318081&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46886960 104152442 CHEMBL1094135 ZINC49070510 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651225 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4OC(F)(F)F)nc3-c12 InChI=1S/C18H15F3N6O2/c1-27-15-10(14(26-27)16(22)28)7-6-9-8-23-17(25-13(9)15)24-11-4-2-3-5-12(11)29-18(19,20)21/h2-5,8H,6-7H2,1H3,(H2,22,28)(H,23,24,25) GCFCQBCBKXQUCD-UHFFFAOYSA-N 50329932 1-methyl-8-(2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272089 Serine/threonine-protein kinase PLK1 Homo sapiens 117 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52947958 123109047 CHEMBL1272089 ZINC64512419 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651226 CNC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C18H18N6O/c1-19-17(25)15-13-9-8-11-10-20-18(21-12-6-4-3-5-7-12)22-14(11)16(13)24(2)23-15/h3-7,10H,8-9H2,1-2H3,(H,19,25)(H,20,21,22) UOZGSFYRTXKQQR-UHFFFAOYSA-N 31533 pyrazolo[4,3-h]quinazoline-3-carboxamide, 16 Serine/threonine-protein kinase PLK1 Homo sapiens 4215 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44236353 172097434 ZINC42201316 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651227 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(N)=O)nc-21 InChI=1S/C29H31N7O3/c1-5-16-8-7-9-17(6-2)23(16)33-28(38)25-20-12-10-19-15-31-29(34-24(19)26(20)36(3)35-25)32-21-13-11-18(27(30)37)14-22(21)39-4/h7-9,11,13-15H,5-6,10,12H2,1-4H3,(H2,30,37)(H,33,38)(H,31,32,34) ZWRLLBAFCKACAL-UHFFFAOYSA-N 50349099 CHEMBL1808338 Serine/threonine-protein kinase PLK1 Homo sapiens 3034 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349099&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44556214 136355785 CHEMBL1808338 ZINC72175782 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651228 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)nc-21 InChI=1S/C35H42N8O3/c1-6-21-9-8-10-22(7-2)29(21)39-34(45)31-26-13-11-24-20-36-35(40-30(24)32(26)43(4)41-31)38-27-14-12-23(19-28(27)46-5)33(44)37-25-15-17-42(3)18-16-25/h8-10,12,14,19-20,25H,6-7,11,13,15-18H2,1-5H3,(H,37,44)(H,39,45)(H,36,38,40) WGZYFFJOGZFXBF-UHFFFAOYSA-N 50349101 CHEMBL1808340 Serine/threonine-protein kinase PLK1 Homo sapiens 237 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349101&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44556163 136355787 CHEMBL1808340 ZINC72176004 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651229 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(=O)NCCN(C)C)nc-21 InChI=1S/C33H40N8O3/c1-7-20-10-9-11-21(8-2)27(20)37-32(43)29-24-14-12-23-19-35-33(38-28(23)30(24)41(5)39-29)36-25-15-13-22(18-26(25)44-6)31(42)34-16-17-40(3)4/h9-11,13,15,18-19H,7-8,12,14,16-17H2,1-6H3,(H,34,42)(H,37,43)(H,35,36,38) ATKPMPVOTNGCIB-UHFFFAOYSA-N 50349103 CHEMBL1808341 Serine/threonine-protein kinase PLK1 Homo sapiens 1652 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349103&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44556329 136355789 CHEMBL1808341 ZINC72177292 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651257 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21 InChI=1S/C27H28N6O/c1-4-17-10-9-11-18(5-2)22(17)30-26(34)24-21-15-14-19-16-28-27(29-20-12-7-6-8-13-20)31-23(19)25(21)33(3)32-24/h6-13,16H,4-5,14-15H2,1-3H3,(H,30,34)(H,28,29,31) LHQIHZSYSNEJIN-UHFFFAOYSA-N 50349096 CHEMBL1808334 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56666592 136355782 CHEMBL1808334 ZINC72177007 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651258 Cn1nc(C(=O)Nc2ccccc2)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C23H20N6O/c1-29-21-18(20(28-29)22(30)25-16-8-4-2-5-9-16)13-12-15-14-24-23(27-19(15)21)26-17-10-6-3-7-11-17/h2-11,14H,12-13H2,1H3,(H,25,30)(H,24,26,27) VRZQAXBLQMWLAF-UHFFFAOYSA-N 31537 pyrazolo[4,3-h]quinazoline-3-carboxamide, 20 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31537&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11486283 172097438 ZINC42201308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651259 Cn1nc(C(=O)NCc2ccccc2)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C24H22N6O/c1-30-22-19(21(29-30)23(31)25-14-16-8-4-2-5-9-16)13-12-17-15-26-24(28-20(17)22)27-18-10-6-3-7-11-18/h2-11,15H,12-14H2,1H3,(H,25,31)(H,26,27,28) KPUBBCGAMBGWSV-UHFFFAOYSA-N 31538 pyrazolo[4,3-h]quinazoline-3-carboxamide, 21 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31538&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44232693 172097439 ZINC43078492 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651260 Cn1nc(C(=O)NCCc2ccccc2)c2CCc3cnc(Nc4ccccc4)nc3-c12 InChI=1S/C25H24N6O/c1-31-23-20(22(30-31)24(32)26-15-14-17-8-4-2-5-9-17)13-12-18-16-27-25(29-21(18)23)28-19-10-6-3-7-11-19/h2-11,16H,12-15H2,1H3,(H,26,32)(H,27,28,29) AOWRNBGAGSLHKJ-UHFFFAOYSA-N 50349107 CHEMBL1808335 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349107&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56676833 136355793 CHEMBL1808335 ZINC72175979 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651261 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3OC)nc-21 InChI=1S/C28H30N6O2/c1-5-17-10-9-11-18(6-2)23(17)31-27(35)25-20-15-14-19-16-29-28(32-24(19)26(20)34(3)33-25)30-21-12-7-8-13-22(21)36-4/h7-13,16H,5-6,14-15H2,1-4H3,(H,31,35)(H,29,30,32) FRHNISWTMRBFQX-UHFFFAOYSA-N 50349097 CHEMBL1808336 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349097&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44555761 136355783 CHEMBL1808336 ZINC72175896 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651262 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3OC(F)(F)F)nc-21 InChI=1S/C28H27F3N6O2/c1-4-16-9-8-10-17(5-2)22(16)34-26(38)24-19-14-13-18-15-32-27(35-23(18)25(19)37(3)36-24)33-20-11-6-7-12-21(20)39-28(29,30)31/h6-12,15H,4-5,13-14H2,1-3H3,(H,34,38)(H,32,33,35) ONVBPMGFFPXAMJ-UHFFFAOYSA-N 50349098 CHEMBL1808337 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349098&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53363307 136355784 CHEMBL1808337 ZINC72175707 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651263 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(N)=O)nc-21 InChI=1S/C29H28F3N7O3/c1-4-15-7-6-8-16(5-2)22(15)36-27(41)24-19-11-9-18-14-34-28(37-23(18)25(19)39(3)38-24)35-20-12-10-17(26(33)40)13-21(20)42-29(30,31)32/h6-8,10,12-14H,4-5,9,11H2,1-3H3,(H2,33,40)(H,36,41)(H,34,35,37) BJCDONGBHGLZHP-UHFFFAOYSA-N 50349100 CHEMBL1808339 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349100&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56676834 136355786 CHEMBL1808339 ZINC72177017 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651264 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NC3CCN(C)CC3)nc-21 InChI=1S/C35H39F3N8O3/c1-5-20-8-7-9-21(6-2)28(20)42-33(48)30-25-12-10-23-19-39-34(43-29(23)31(25)46(4)44-30)41-26-13-11-22(18-27(26)49-35(36,37)38)32(47)40-24-14-16-45(3)17-15-24/h7-9,11,13,18-19,24H,5-6,10,12,14-17H2,1-4H3,(H,40,47)(H,42,48)(H,39,41,43) JFOAJUGFHDCBJJ-UHFFFAOYSA-N 50349102 CHEMBL1236095::US11208696, Example 3 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349102&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search SVE 5NTT,5AP7,2X9E 44556162 136355788 CHEMBL1236095 ZINC58649424 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651265 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NCCN(C)C)nc-21 InChI=1S/C33H37F3N8O3/c1-6-19-9-8-10-20(7-2)26(19)40-31(46)28-23-13-11-22-18-38-32(41-27(22)29(23)44(5)42-28)39-24-14-12-21(17-25(24)47-33(34,35)36)30(45)37-15-16-43(3)4/h8-10,12,14,17-18H,6-7,11,13,15-16H2,1-5H3,(H,37,45)(H,40,46)(H,38,39,41) MJJRBRKTAAJGIY-UHFFFAOYSA-N 50349104 CHEMBL1808342 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349104&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56676835 136355790 CHEMBL1808342 ZINC72177126 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651266 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)C(=O)N3CCC[C@@H]3CN3CCCC3)nc-21 InChI=1S/C38H46N8O3/c1-5-24-11-9-12-25(6-2)32(24)41-36(47)34-29-16-14-27-22-39-38(42-33(27)35(29)44(3)43-34)40-30-17-15-26(21-31(30)49-4)37(48)46-20-10-13-28(46)23-45-18-7-8-19-45/h9,11-12,15,17,21-22,28H,5-8,10,13-14,16,18-20,23H2,1-4H3,(H,41,47)(H,39,40,42)/t28-/m1/s1 LTKUHPWNVCRTSA-MUUNZHRXSA-N 50349105 CHEMBL1808343 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349105&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44555519 136355791 CHEMBL1808343 ZINC72178494 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50651267 CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)N3CCC[C@@H]3CN3CCCC3)nc-21 InChI=1S/C38H43F3N8O3/c1-4-23-10-8-11-24(5-2)31(23)44-35(50)33-28-15-13-26-21-42-37(45-32(26)34(28)47(3)46-33)43-29-16-14-25(20-30(29)52-38(39,40)41)36(51)49-19-9-12-27(49)22-48-17-6-7-18-48/h8,10-11,14,16,20-21,27H,4-7,9,12-13,15,17-19,22H2,1-3H3,(H,44,50)(H,42,43,45)/t27-/m1/s1 WZZWJWWPQJVGAJ-HHHXNRCGSA-N 50349106 CHEMBL1807300 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.122 10.7270/Q2R211RS 21723120 Caldarelli, M; Angiolini, M; Disingrini, T; Donati, D; Guanci, M; Nuvoloni, S; Posteri, H; Quartieri, F; Silvagni, M; Colombo, R Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50349106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50349106&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56659726 136355792 CHEMBL1807300 ZINC72176257 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50682481 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.190000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50682510 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50689746 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50689781 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50669654 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50676959 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50678337 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50674156 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50675507 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50678433 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50686823 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50669811 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Serine/threonine-protein kinase PLK1 Homo sapiens 47 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50671158 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50672798 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50675660 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50677116 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50688538 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50672901 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50679986 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Serine/threonine-protein kinase PLK1 Homo sapiens 20 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50678699 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50681554 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50681618 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50681645 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50685747 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50670127 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50681710 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50684554 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50670252 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50674599 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50676076 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50685990 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50686045 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50684742 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50673443 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50674865 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50674877 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Serine/threonine-protein kinase PLK1 Homo sapiens 130 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50680565 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687728 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50692047 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50677878 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50679292 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase PLK1 Homo sapiens 0.094000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50689383 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50690911 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50692153 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50675060 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50675105 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50682280 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50678018 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50686455 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50675275 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704136 CC(C)C\C=C\[C@@H](C)[C@H]1CC[C@H]2[C@H](CCc3cc(O)ccc3C)[C@@H](O)CC[C@]12C InChI=1S/C27H42O2/c1-18(2)7-6-8-20(4)24-13-14-25-23(26(29)15-16-27(24,25)5)12-10-21-17-22(28)11-9-19(21)3/h6,8-9,11,17-18,20,23-26,28-29H,7,10,12-16H2,1-5H3/b8-6+/t20-,23+,24-,25+,26+,27-/m1/s1 ZXFBTQCKAZQQFA-CNIJLMKKSA-N 50358243 CHEMBL1922224 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358243&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54764923 136962267 CHEMBL1922224 ZINC73196212 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704137 CC(C)C\C=C\[C@@H](C)[C@H]1CC[C@H]2[C@H](CCc3cc(O)ccc3C)C(=O)CC[C@]12C InChI=1S/C27H40O2/c1-18(2)7-6-8-20(4)24-13-14-25-23(26(29)15-16-27(24,25)5)12-10-21-17-22(28)11-9-19(21)3/h6,8-9,11,17-18,20,23-25,28H,7,10,12-16H2,1-5H3/b8-6+/t20-,23+,24-,25+,27-/m1/s1 MDPPOIXSNMVHOD-FBPKMIEBSA-N 50358244 CALICOFEROL A Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358244&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9547698 136962268 ZINC38791899 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704138 CC(C)C(=C)CC[C@@H](C)[C@H]1CC[C@H]2[C@H](CCc3cc(O)ccc3C)C(=O)CC[C@]12C InChI=1S/C28H42O2/c1-18(2)19(3)7-8-21(5)25-13-14-26-24(27(30)15-16-28(25,26)6)12-10-22-17-23(29)11-9-20(22)4/h9,11,17-18,21,24-26,29H,3,7-8,10,12-16H2,1-2,4-6H3/t21-,24+,25-,26+,28-/m1/s1 HEUHMWCGNUTYFR-SOVKOMHZSA-N 50358245 CHEMBL1922225 Serine/threonine-protein kinase PLK1 Homo sapiens 100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358245&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10047202 136962269 CHEMBL1922225 ZINC73196506 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50693820 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50695304 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704139 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H](CCc3cc(O)ccc3C)C(=O)CC[C@]12C InChI=1S/C27H42O2/c1-18(2)7-6-8-20(4)24-13-14-25-23(26(29)15-16-27(24,25)5)12-10-21-17-22(28)11-9-19(21)3/h9,11,17-18,20,23-25,28H,6-8,10,12-16H2,1-5H3/t20-,23+,24-,25+,27-/m1/s1 OZROZYIBIZOAQQ-DLBXBJKMSA-N 50358246 CHEMBL456936 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358246&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5283685 136962270 CHEMBL456936 ZINC33820639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704140 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@H](CCc3cc(O)ccc3C)[C@H](O)CC[C@]12C InChI=1S/C27H44O2/c1-18(2)7-6-8-20(4)24-13-14-25-23(26(29)15-16-27(24,25)5)12-10-21-17-22(28)11-9-19(21)3/h9,11,17-18,20,23-26,28-29H,6-8,10,12-16H2,1-5H3/t20-,23+,24-,25+,26-,27-/m1/s1 RAIDHOLJIAWOMY-DKQGWWAXSA-N 50358247 ASTROGORGIADIOL Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358247&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5283727 136962271 ZINC33820668 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704141 CC(C)CCC[C@@H](C)[C@H]1[C@@H](O)C[C@H]2[C@H](CCc3cc(O)ccc3C)C(=O)CC[C@]12C InChI=1S/C27H42O3/c1-17(2)7-6-8-19(4)26-25(30)16-23-22(24(29)13-14-27(23,26)5)12-10-20-15-21(28)11-9-18(20)3/h9,11,15,17,19,22-23,25-26,28,30H,6-8,10,12-14,16H2,1-5H3/t19-,22+,23+,25+,26+,27+/m1/s1 USFQLAVWHQCNDG-AYEIPMSGSA-N 50358248 CHEMBL456294 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358248&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9547398 136962272 CHEMBL456294 ZINC38791692 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704142 CC(C)C(=C)CC[C@@H](C)[C@H]1CC[C@H]2[C@H](CCc3cc(O)ccc3C)[C@H](O)CC[C@]12C InChI=1S/C28H44O2/c1-18(2)19(3)7-8-21(5)25-13-14-26-24(27(30)15-16-28(25,26)6)12-10-22-17-23(29)11-9-20(22)4/h9,11,17-18,21,24-27,29-30H,3,7-8,10,12-16H2,1-2,4-6H3/t21-,24+,25-,26+,27-,28-/m1/s1 GKFHBWBDOADOEV-HFOUWSASSA-N 50358249 CHEMBL515982 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358249&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10024683 136962273 CHEMBL515982 ZINC34105357 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704143 CC(C)CCC[C@@H](C)[C@H]1[C@@H](O)C[C@H]2[C@H](CCc3cc(O)ccc3C)[C@H](O)CC[C@]12C InChI=1S/C27H44O3/c1-17(2)7-6-8-19(4)26-25(30)16-23-22(24(29)13-14-27(23,26)5)12-10-20-15-21(28)11-9-18(20)3/h9,11,15,17,19,22-26,28-30H,6-8,10,12-14,16H2,1-5H3/t19-,22+,23+,24-,25+,26+,27+/m1/s1 XXLLTYLTCDARFZ-OHSNSYSLSA-N 50358250 CALICOFEROL B Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2011.09.028 10.7270/Q2HX1D38 21982797 Lai, D; Yu, S; van Ofwegen, L; Totzke, F; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358250&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10047545 136962274 ZINC40873362 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50692607 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Serine/threonine-protein kinase PLK1 Homo sapiens 280 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50694032 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710549 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc3c(CCNC3=O)n2C)c1 InChI=1S/C24H26F3N7O2/c1-32-9-11-34(12-10-32)15-3-4-21(36-24(25,26)27)18(13-15)31-23-29-7-5-17(30-23)20-14-16-19(33(20)2)6-8-28-22(16)35/h3-5,7,13-14H,6,8-12H2,1-2H3,(H,28,35)(H,29,30,31) CYXABCVHENZAID-UHFFFAOYSA-N 50361088 CHEMBL1933582 Serine/threonine-protein kinase PLK1 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361088&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 664 4A4O 25210579 136965150 CHEMBL1933582 ZINC43205093 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710550 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc(cn2C)C(N)=O)c1 InChI=1S/C22H24F3N7O2/c1-30-7-9-32(10-8-30)15-3-4-19(34-22(23,24)25)17(12-15)29-21-27-6-5-16(28-21)18-11-14(20(26)33)13-31(18)2/h3-6,11-13H,7-10H2,1-2H3,(H2,26,33)(H,27,28,29) HGBZKLOZYQAERY-UHFFFAOYSA-N 50361089 CHEMBL1933576 Serine/threonine-protein kinase PLK1 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361089&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 939 4A4L 54759168 136965151 CHEMBL1933576 ZINC73219127 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710551 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc(cn2CC(F)(F)F)C(N)=O)c1 InChI=1S/C23H23F6N7O2/c1-34-6-8-35(9-7-34)15-2-3-19(38-23(27,28)29)17(11-15)33-21-31-5-4-16(32-21)18-10-14(20(30)37)12-36(18)13-22(24,25)26/h2-5,10-12H,6-9,13H2,1H3,(H2,30,37)(H,31,32,33) KZKAHLUAYFSINX-UHFFFAOYSA-N 50361090 CHEMBL1933577 Serine/threonine-protein kinase PLK1 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361090&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57403865 136965152 CHEMBL1933577 ZINC73239901 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710552 Cn1cc(cc1-c1ccnc(Nc2cc(ccc2OC(F)(F)F)N2CCNCC2)n1)C(N)=O InChI=1S/C21H22F3N7O2/c1-30-12-13(19(25)32)10-17(30)15-4-5-27-20(28-15)29-16-11-14(31-8-6-26-7-9-31)2-3-18(16)33-21(22,23)24/h2-5,10-12,26H,6-9H2,1H3,(H2,25,32)(H,27,28,29) NWYFEBANPAQUIZ-UHFFFAOYSA-N 50361091 CHEMBL1933578 Serine/threonine-protein kinase PLK1 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361091&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57400314 136965153 CHEMBL1933578 ZINC73239904 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710553 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc3c(CCNC3=O)n2CC(F)(F)F)c1 InChI=1S/C25H25F6N7O2/c1-36-8-10-37(11-9-36)15-2-3-21(40-25(29,30)31)18(12-15)35-23-33-6-4-17(34-23)20-13-16-19(5-7-32-22(16)39)38(20)14-24(26,27)28/h2-4,6,12-13H,5,7-11,14H2,1H3,(H,32,39)(H,33,34,35) WAQLLQUEYANORM-UHFFFAOYSA-N 50361092 CHEMBL1933583 Serine/threonine-protein kinase PLK1 Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361092&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57398639 136965154 CHEMBL1933583 ZINC73390741 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710554 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc3c(CCNC3=O)n2CCO)c1 InChI=1S/C25H28F3N7O3/c1-33-8-10-34(11-9-33)16-2-3-22(38-25(26,27)28)19(14-16)32-24-30-6-4-18(31-24)21-15-17-20(35(21)12-13-36)5-7-29-23(17)37/h2-4,6,14-15,36H,5,7-13H2,1H3,(H,29,37)(H,30,31,32) IOLZTNBOBLBSNG-UHFFFAOYSA-N 50361093 CHEMBL1933584 Serine/threonine-protein kinase PLK1 Homo sapiens 102 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57396885 136965155 CHEMBL1933584 ZINC73219119 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710555 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc(cn2CCO)C(N)=O)c1 InChI=1S/C23H26F3N7O3/c1-31-6-8-32(9-7-31)16-2-3-20(36-23(24,25)26)18(13-16)30-22-28-5-4-17(29-22)19-12-15(21(27)35)14-33(19)10-11-34/h2-5,12-14,34H,6-11H2,1H3,(H2,27,35)(H,28,29,30) QQIWAVQDVGCCQI-UHFFFAOYSA-N 50361094 CHEMBL1933579 Serine/threonine-protein kinase PLK1 Homo sapiens 151 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361094&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57391650 136965156 CHEMBL1933579 ZINC82158054 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710557 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc(cn2CCOC2CCCCO2)C(N)=O)c1 InChI=1S/C28H34F3N7O4/c1-36-9-11-37(12-10-36)20-5-6-24(42-28(29,30)31)22(17-20)35-27-33-8-7-21(34-27)23-16-19(26(32)39)18-38(23)13-15-41-25-4-2-3-14-40-25/h5-8,16-18,25H,2-4,9-15H2,1H3,(H2,32,39)(H,33,34,35) QSICZEGMHLTDAG-UHFFFAOYSA-N 50361095 CHEMBL1933580 Serine/threonine-protein kinase PLK1 Homo sapiens 272 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57395119 136965157 CHEMBL1933580 ZINC82157737 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710559 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2nccc(n2)-c2cc3c(CCN(C(=O)OC(C)(C)C)C3=O)n2C)c1 InChI=1S/C29H34F3N7O4/c1-28(2,3)43-27(41)39-11-9-22-19(25(39)40)17-23(37(22)5)20-8-10-33-26(34-20)35-21-16-18(38-14-12-36(4)13-15-38)6-7-24(21)42-29(30,31)32/h6-8,10,16-17H,9,11-15H2,1-5H3,(H,33,34,35) XZIWPAQTNPWRMB-UHFFFAOYSA-N 50361096 CHEMBL1933585 Serine/threonine-protein kinase PLK1 Homo sapiens 817 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57391651 136965158 CHEMBL1933585 ZINC73219123 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710560 Nc1nccc(n1)-c1cc2c(CCNC2=O)[nH]1 InChI=1S/C11H11N5O/c12-11-14-4-2-8(16-11)9-5-6-7(15-9)1-3-13-10(6)17/h2,4-5,15H,1,3H2,(H,13,17)(H2,12,14,16) FMVMPEYKBFJPAD-UHFFFAOYSA-N 27351 2-(2-aminopyrimidin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::Pyrrolopyridinone, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 1131 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27351&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11300082 57299060 ZINC28970242 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50694309 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50704512 CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12 InChI=1S/C26H25ClF3N5O3/c1-25(2,37)14-22(36)31-9-11-35-10-8-20-23(35)24(33-15-32-20)34-17-6-7-21(19(27)13-17)38-18-5-3-4-16(12-18)26(28,29)30/h3-8,10,12-13,15,37H,9,11,14H2,1-2H3,(H,31,36)(H,32,33,34) ZYQXEVJIFYIBHZ-UHFFFAOYSA-N 50358430 CHEMBL1614725 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm2008634 10.7270/Q23R0T93 22003817 Ishikawa, T; Seto, M; Banno, H; Kawakita, Y; Oorui, M; Taniguchi, T; Ohta, Y; Tamura, T; Nakayama, A; Miki, H; Kamiguchi, H; Tanaka, T; Habuka, N; Sogabe, S; Yano, J; Aertgeerts, K; Kamiyama, K Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358430&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 03P 3RCD,3W2O,3POZ 11620908 136962454 CHEMBL1614725 ZINC64746555 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710595 NC(=O)c1c[nH]c(c1)-c1ccnc(N)n1 InChI=1S/C9H9N5O/c10-8(15)5-3-7(13-4-5)6-1-2-12-9(11)14-6/h1-4,13H,(H2,10,15)(H2,11,12,14) LZHRODNGEZPNSC-UHFFFAOYSA-N 50361097 CHEMBL1933575 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361097&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57402115 136965159 CHEMBL1933575 ZINC73224899 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50710596 Cn1cc(cc1-c1ccnc(Nc2cc(ccc2OC(F)(F)F)N2CCN(CC2)C(=O)OC(C)(C)C)n1)C(N)=O InChI=1S/C26H30F3N7O4/c1-25(2,3)40-24(38)36-11-9-35(10-12-36)17-5-6-21(39-26(27,28)29)19(14-17)33-23-31-8-7-18(32-23)20-13-16(22(30)37)15-34(20)4/h5-8,13-15H,9-12H2,1-4H3,(H2,30,37)(H,31,32,33) ZZEICTZAIFYWLM-UHFFFAOYSA-N 50361098 CHEMBL1933581 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.11.065 10.7270/Q2W959NX 22154349 Caruso, M; Valsasina, B; Ballinari, D; Bertrand, J; Brasca, MG; Caldarelli, M; Cappella, P; Fiorentini, F; Gianellini, LM; Scolaro, A; Beria, I Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361098&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57403866 136965160 CHEMBL1933581 ZINC73223481 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50694379 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50695896 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50695954 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Serine/threonine-protein kinase PLK1 Homo sapiens 1800 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50693398 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50706489 CN(C)CCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C InChI=1S/C25H33Cl2N5O3S/c1-25(2,3)19-15-16(22(36-19)29-24(35)28-18-8-6-7-17(26)21(18)27)23(34)32-10-9-20(33)31(13-14-32)12-11-30(4)5/h6-8,15H,9-14H2,1-5H3,(H2,28,29,35) SIUIQMQVKUUQQF-UHFFFAOYSA-N 50359359 CHEMBL1929238 Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50359359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50359359&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search P7C 3P7C 53384644 136963383 CHEMBL1929238 ZINC72318122 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50706490 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50696402 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50696454 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50696562 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50715239 Cn1c2c(C(C#N)C3(CCNCC3)NC2=O)c2ccc(Cl)c(Cl)c12 InChI=1S/C17H16Cl2N4O/c1-23-14-9(2-3-11(18)13(14)19)12-10(8-20)17(4-6-21-7-5-17)22-16(24)15(12)23/h2-3,10,21H,4-7H2,1H3,(H,22,24) OWAWOKKHZNRHGV-UHFFFAOYSA-N 50363167 CHEMBL1945559 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm201286z 10.7270/Q20G3KK7 22136433 Huber, K; Brault, L; Fedorov, O; Gasser, C; Filippakopoulos, P; Bullock, AN; Fabbro, D; Trappe, J; Schwaller, J; Knapp, S; Bracher, F Ludwig-Maximilians University of Munich http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363167&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search KHC 6YTG,6Z2V,6YU1 54613583 136967229 CHEMBL1945559 ZINC73197039 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50720095 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase PLK1 Homo sapiens >24000 ChEMBL 10.1073/pnas.0502000102 10.7270/Q2PC32TB 16249345 Conway, JG; McDonald, B; Parham, J; Keith, B; Rusnak, DW; Shaw, E; Jansen, M; Lin, P; Payne, A; Crosby, RM; Johnson, JH; Frick, L; Lin, MH; Depee, S; Tadepalli, S; Votta, B; James, I; Fuller, K; Chambers, TJ; Kull, FC; Chamberlain, SD; Hutchins, JT GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50720133 CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc12)-c1nonc1N InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38) YOVNFNXUCOWYSG-UHFFFAOYSA-N 14047 Aminofurazanyl-azabenzimidazole 6n::N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1124/jpet.106.110635 10.7270/Q2DV1KBV 17018693 Doe, C; Bentley, R; Behm, DJ; Lafferty, R; Stavenger, R; Jung, D; Bamford, M; Panchal, T; Grygielko, E; Wright, LL; Smith, GK; Chen, Z; Webb, C; Khandekar, S; Yi, T; Kirkpatrick, R; Dul, E; Jolivette, L; Marino, JP; Willette, R; Lee, D; Hu, E GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14047&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16095342 46514412 ZINC14954335 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50720134 CCn1c(nc2cncc(C(=O)N3CC[C@H](N)C3)c12)-c1nonc1N InChI=1S/C15H18N8O2/c1-2-23-12-9(15(24)22-4-3-8(16)7-22)5-18-6-10(12)19-14(23)11-13(17)21-25-20-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,21)/t8-/m0/s1 PHWHNHYZZNJPLB-QMMMGPOBSA-N 50365218 CHEMBL1956071::GSK screening, 29 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1124/jpet.106.110635 10.7270/Q2DV1KBV 17018693 Doe, C; Bentley, R; Behm, DJ; Lafferty, R; Stavenger, R; Jung, D; Bamford, M; Panchal, T; Grygielko, E; Wright, LL; Smith, GK; Chen, Z; Webb, C; Khandekar, S; Yi, T; Kirkpatrick, R; Dul, E; Jolivette, L; Marino, JP; Willette, R; Lee, D; Hu, E GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50365218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50365218&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16095343 136969280 CHEMBL1956071 ZINC35076001 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50722420 CC(C)n1c2CCCC(=O)c2c2C(=O)c3ccccc3-c12 InChI=1S/C18H17NO2/c1-10(2)19-13-8-5-9-14(20)15(13)16-17(19)11-6-3-4-7-12(11)18(16)21/h3-4,6-7,10H,5,8-9H2,1-2H3 DGOKKNPUISUUGY-UHFFFAOYSA-N 50366114 CHEMBL1957190 Serine/threonine-protein kinase PLK1 Homo sapiens >35000 ChEMBL 10.1016/j.bmc.2012.02.017 10.7270/Q2J966T6 22377675 Hundsdorfer, C; Hemmerling, HJ; Gotz, C; Totzke, F; Bednarski, P; Le Borgne, M; Jose, J Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366114&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24764502 136970176 CHEMBL1957190 ZINC73297163 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50722421 Oc1cc2c3c(oc(=O)c4cc(O)c(O)c(oc2=O)c34)c1O InChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H AFSDNFLWKVMVRB-UHFFFAOYSA-N 4078 6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(14),4(16),5,7,11(15),12-hexaene-3,10-dione::CHEMBL6246::ELLAGIC ACID::Elagic Acid::Ellagic acid (18)::Ellagic acid dihydrate::MLS000069632::SMR000058244::cid_5281855 Serine/threonine-protein kinase PLK1 Homo sapiens 3340 ChEMBL 10.1016/j.bmc.2012.02.017 10.7270/Q2J966T6 22377675 Hundsdorfer, C; Hemmerling, HJ; Gotz, C; Totzke, F; Bednarski, P; Le Borgne, M; Jose, J Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4078&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search REF 4YUA,2ZJW,6RWD 5281855 8033769 4775 CHEMBL6246 DB08468 C10788 ZINC03872446 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50836009 COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1 InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32) OGNYUTNQZVRGMN-UHFFFAOYSA-N 14210 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)-quinazoline::CHEMBL202721::N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide::ZM447439 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm050786h 10.7270/Q24J0FXV 16451062 Jung, FH; Pasquet, G; Lambert-van der Brempt, C; Lohmann, JJ; Warin, N; Renaud, F; Germain, H; De Savi, C; Roberts, N; Johnson, T; Dousson, C; Hill, GB; Mortlock, AA; Heron, N; Wilkinson, RW; Wedge, SR; Heaton, SP; Odedra, R; Keen, NJ; Green, S; Brown, E; Thompson, K; Brightwell, S AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14210&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 447 2VRX 9914412 46514557 CHEMBL202721 ZINC22067501 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50851788 Clc1cc2NC(=O)Nc3cnc(C#N)c(OCCCCOc2cc1NCc1cncs1)n3 InChI=1S/C20H18ClN7O3S/c21-13-5-15-17(6-14(13)24-9-12-8-23-11-32-12)30-3-1-2-4-31-19-16(7-22)25-10-18(27-19)28-20(29)26-15/h5-6,8,10-11,24H,1-4,9H2,(H2,26,27,28,29) AZTMYWWWILJAKW-UHFFFAOYSA-N 50224883 7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,16-dioxa-2,4,19,21-tetraaza-tricyclo[15.3.1.0*5,10*]henicosa-1(21),5,7,9,17,19-hexaene-18-crbonitrile::CHEMBL248757 Serine/threonine-protein kinase PLK1 Homo sapiens 6560 ChEMBL 10.1016/j.bmcl.2007.09.063 10.7270/Q2X067WT 17935989 Tao, ZF; Chen, Z; Bui, MH; Kovar, P; Johnson, E; Bouska, J; Zhang, H; Rosenberg, S; Sowin, T; Lin, NH Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224883&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44444843 104096404 CHEMBL248757 ZINC28963230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50867790 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Serine/threonine-protein kinase PLK1 Homo sapiens 53000 ChEMBL 10.1073/pnas.0608798104 10.7270/Q25B03CS 17360485 Manfredi, MG; Ecsedy, JA; Meetze, KA; Balani, SK; Burenkova, O; Chen, W; Galvin, KM; Hoar, KM; Huck, JJ; LeRoy, PJ; Ray, ET; Sells, TB; Stringer, B; Stroud, SG; Vos, TJ; Weatherhead, GS; Wysong, DR; Zhang, M; Bolen, JB; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866769 Nc1nc(N)c2N=C(CCNc2n1)c1ccc(Cl)cc1 InChI=1S/C13H13ClN6/c14-8-3-1-7(2-4-8)9-5-6-17-12-10(18-9)11(15)19-13(16)20-12/h1-4H,5-6H2,(H5,15,16,17,19,20) FYFMYJAVNOJPGZ-UHFFFAOYSA-N 50376345 CHEMBL260620 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376345&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10732141 160855435 CHEMBL260620 ZINC29049565 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866770 Nc1nc(N)c2N=C(CCNc2n1)c1cccc(Cl)c1 InChI=1S/C13H13ClN6/c14-8-3-1-2-7(6-8)9-4-5-17-12-10(18-9)11(15)19-13(16)20-12/h1-3,6H,4-5H2,(H5,15,16,17,19,20) BXYMXPKMWSCVJG-UHFFFAOYSA-N 50376346 CHEMBL259381 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376346&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44450033 160855436 CHEMBL259381 ZINC29049580 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866771 Nc1ncnc2NCCC(=Nc12)c1ccc(Cl)cc1 InChI=1S/C13H12ClN5/c14-9-3-1-8(2-4-9)10-5-6-16-13-11(19-10)12(15)17-7-18-13/h1-4,7H,5-6H2,(H3,15,16,17,18) QPRJVVDEDTZBFD-UHFFFAOYSA-N 50376347 CHEMBL407265 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376347&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10588346 160855437 CHEMBL407265 ZINC29049570 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866772 Nc1ncnc2NCCC(=Nc12)c1cccc(Cl)c1 InChI=1S/C13H12ClN5/c14-9-3-1-2-8(6-9)10-4-5-16-13-11(19-10)12(15)17-7-18-13/h1-3,6-7H,4-5H2,(H3,15,16,17,18) AYMFCWIRJCXDQO-UHFFFAOYSA-N 50376348 CHEMBL407532 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376348&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44450035 160855438 CHEMBL407532 ZINC29049588 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866773 Cc1ccc(cc1)C1=Nc2c(N)ncnc2NCC1 InChI=1S/C14H15N5/c1-9-2-4-10(5-3-9)11-6-7-16-14-12(19-11)13(15)17-8-18-14/h2-5,8H,6-7H2,1H3,(H3,15,16,17,18) ZTBBOGGNXOHIED-UHFFFAOYSA-N 50376349 CHEMBL405233 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376349&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44450060 160855439 CHEMBL405233 ZINC29049748 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866823 Nc1ncnc2NCCC(=Nc12)c1ccccc1 InChI=1S/C13H13N5/c14-12-11-13(17-8-16-12)15-7-6-10(18-11)9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H3,14,15,16,17) WNTAZUFBXXQBAO-UHFFFAOYSA-N 50376344 CHEMBL262623 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376344&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10705154 160855434 CHEMBL262623 ZINC29049756 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866827 Nc1nc(N)c2N=C(CCNc2n1)c1ccccc1 InChI=1S/C13H14N6/c14-11-10-12(19-13(15)18-11)16-7-6-9(17-10)8-4-2-1-3-5-8/h1-5H,6-7H2,(H5,14,15,16,18,19) ZPTFXYLUWCTNBG-UHFFFAOYSA-N 50376351 CHEMBL259380 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376351&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10538870 160855441 CHEMBL259380 ZINC29049575 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50866828 Cc1cccc(c1)C1=Nc2c(N)ncnc2NCC1 InChI=1S/C14H15N5/c1-9-3-2-4-10(7-9)11-5-6-16-14-12(19-11)13(15)17-8-18-14/h2-4,7-8H,5-6H2,1H3,(H3,15,16,17,18) KZTOUMBNPVCTLR-UHFFFAOYSA-N 50376350 CHEMBL263902 Serine/threonine-protein kinase PLK1 Homo sapiens 50000 ChEMBL 10.1016/j.bmcl.2008.03.021 10.7270/Q2KP831H 18362070 Gracias, V; Ji, Z; Akritopoulou-Zanze, I; Abad-Zapatero, C; Huth, JR; Song, D; Hajduk, PJ; Johnson, EF; Glaser, KB; Marcotte, PA; Pease, L; Soni, NB; Stewart, KD; Davidsen, SK; Michaelides, MR; Djuric, SW Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50376350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50376350&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44450059 160855440 CHEMBL263902 ZINC29049744 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50878964 Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(NC(=O)c2ccnc(c2)N2CCCC2)ccc1C InChI=1S/C27H27N5O2/c1-17-6-8-22(29-26(33)20-10-11-28-25(15-20)32-12-4-5-13-32)16-24(17)23-9-7-21(14-18(23)2)27-31-30-19(3)34-27/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,29,33) OBHNTFJGFUEQCQ-UHFFFAOYSA-N 50265035 CHEMBL495729::N-(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-yl)-2-(pyrrolidin-1-yl)isonicotinamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265035&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10479082 104112853 CHEMBL495729 ZINC38941486 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50878974 Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)NC1CC1 InChI=1S/C23H25N3O2/c1-14-2-3-17(23(27)25-18-5-6-18)12-20(14)16-4-7-19-21(13-16)28-26-22(19)15-8-10-24-11-9-15/h2-4,7,12-13,15,18,24H,5-6,8-11H2,1H3,(H,25,27) UEWLDVUSFNQXKA-UHFFFAOYSA-N 50265371 CHEMBL497563::N-cyclopropyl-4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265371&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9864418 104113148 CHEMBL497563 ZINC03938228 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50878984 Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)NC1CC1 InChI=1S/C21H21N3O2/c1-12-4-5-15(20(25)22-17-7-8-17)11-19(12)18-9-6-16(10-13(18)2)21-24-23-14(3)26-21/h4-6,9-11,17H,7-8H2,1-3H3,(H,22,25) UBVTVSINEVHYSY-UHFFFAOYSA-N 50265033 CHEMBL522579::N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265033&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search G6A 3E92 10089048 104112851 CHEMBL522579 DB07811 ZINC33969098 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50878993 Cc1ccc(cc1-c1ccc2c(c1)nnn(CC1CC1)c2=O)C(=O)NC1CC1 InChI=1S/C22H22N4O2/c1-13-2-5-16(21(27)23-17-7-8-17)10-19(13)15-6-9-18-20(11-15)24-25-26(22(18)28)12-14-3-4-14/h2,5-6,9-11,14,17H,3-4,7-8,12H2,1H3,(H,23,27) GURGQFBRXVKIQG-UHFFFAOYSA-N 50265154 CHEMBL521734::N-cyclopropyl-3-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-7-yl)-4-methylbenzamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265154&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580532 104112950 CHEMBL521734 ZINC40974802 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50879002 Cc1ccc(cc1-c1ccc2ccncc2c1)C(=O)NC1CC1 InChI=1S/C20H18N2O/c1-13-2-3-16(20(23)22-18-6-7-18)11-19(13)15-5-4-14-8-9-21-12-17(14)10-15/h2-5,8-12,18H,6-7H2,1H3,(H,22,23) VAGUQCZJQQNYIR-UHFFFAOYSA-N 50265259 CHEMBL526639::N-cyclopropyl-3-(isoquinolin-7-yl)-4-methylbenzamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265259&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580649 104113048 CHEMBL526639 ZINC40973029 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50879012 Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1 InChI=1S/C22H24N2O2/c1-14-2-5-18(22(26)24-19-10-11-19)12-20(14)16-6-8-17(9-7-16)21(25)23-13-15-3-4-15/h2,5-9,12,15,19H,3-4,10-11,13H2,1H3,(H,23,25)(H,24,26) BOPSUAHGQHFKGG-UHFFFAOYSA-N 50263093 6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopropylamide 4'-cyclopropylmethyl-amide::CHEMBL478649::N3-cyclopropyl-N4'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide::N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search GK5 3D7Z 24856363 104111567 CHEMBL478649 DB07835 ZINC03961852 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50879021 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc(cc2C)-c2nnc(C)o2)CC1 InChI=1S/C30H33N5O2/c1-20-5-11-26(18-28(20)27-12-10-25(17-21(27)2)30-33-32-22(3)37-30)31-29(36)24-8-6-23(7-9-24)19-35-15-13-34(4)14-16-35/h5-12,17-18H,13-16,19H2,1-4H3,(H,31,36) HSCYIVKNKNXHIF-UHFFFAOYSA-N 50265069 CHEMBL497350::N-(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265069&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580449 104112882 CHEMBL497350 ZINC40975401 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50879030 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc3ccncc3c2)CC1 InChI=1S/C29H30N4O/c1-21-3-10-27(18-28(21)25-9-8-23-11-12-30-19-26(23)17-25)31-29(34)24-6-4-22(5-7-24)20-33-15-13-32(2)14-16-33/h3-12,17-19H,13-16,20H2,1-2H3,(H,31,34) IYCITBYBDPSBBJ-UHFFFAOYSA-N 50265287 CHEMBL521887::N-(3-(isoquinolin-7-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265287&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580689 104113075 CHEMBL521887 ZINC40428835 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50879039 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc3c(N)noc3c2)CC1 InChI=1S/C27H29N5O2/c1-18-3-9-22(16-24(18)21-8-10-23-25(15-21)34-30-26(23)28)29-27(33)20-6-4-19(5-7-20)17-32-13-11-31(2)12-14-32/h3-10,15-16H,11-14,17H2,1-2H3,(H2,28,30)(H,29,33) BGLPZSPBYFJHQQ-UHFFFAOYSA-N 50265370 CHEMBL497353::N-(3-(3-aminobenzo[d]isoxazol-6-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265370&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580778 104113147 CHEMBL497353 ZINC40975685 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50879048 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc(cc2)-c2csc(N)n2)CC1 InChI=1S/C29H31N5OS/c1-20-3-12-25(17-26(20)22-8-10-23(11-9-22)27-19-36-29(30)32-27)31-28(35)24-6-4-21(5-7-24)18-34-15-13-33(2)14-16-34/h3-12,17,19H,13-16,18H2,1-2H3,(H2,30,32)(H,31,35) BGOWMSRXCRUANU-UHFFFAOYSA-N 50264990 CHEMBL496129::N-(4'-(2-aminothiazol-4-yl)-6-methylbiphenyl-3-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264990&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580358 104112819 CHEMBL496129 ZINC40952530 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50885206 COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 QDLHCMPXEPAAMD-QAIWCSMKSA-N 15234 (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate::CHEMBL428496::NSC221019::Wortmannin::Wortmannin, Wm::cid_312145 Serine/threonine-protein kinase PLK1 Homo sapiens 1300 ChEMBL 10.1042/BJ20070797 10.7270/Q27082B4 17850214 Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15234&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search KWT 3HHM,1E7U,7OTV,3D5X 312145 46515542 52289 CHEMBL428496 DB08059 6060 C15181 ZINC01619592 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50885207 O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1 InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 CZQHHVNHHHRRDU-UHFFFAOYSA-N 12915 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one::2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one::CHEMBL98350::LY294002::US10308662, Compound LY294002::US9505780, LY294002 Serine/threonine-protein kinase PLK1 Homo sapiens 2000 ChEMBL 10.1042/BJ20070797 10.7270/Q27082B4 17850214 Bain, J; Plater, L; Elliott, M; Shpiro, N; Hastie, CJ; McLauchlan, H; Klevernic, I; Arthur, JS; Alessi, DR; Cohen, P University of Dundee http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search LY2 1E7V,1YI3,4AZT,4CFK,6G0D 3973 46509407 65329 CHEMBL98350 DB02656 6004 C15195 ZINC37858693 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892360 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900304 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900305 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900306 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900307 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900308 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900309 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900310 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900311 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900312 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900313 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900314 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50900315 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892363 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892364 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892365 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892366 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892367 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Serine/threonine-protein kinase PLK1 Homo sapiens 5000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892368 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892369 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892370 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892371 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892372 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892374 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892375 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892376 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892377 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892378 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892379 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892381 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892382 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892383 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892384 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892385 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892361 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50892362 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50882523 NC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C28H28N4O2/c29-27(33)21-11-14-23-24(17-21)31-28(34)25(23)26(20-7-3-1-4-8-20)30-22-12-9-19(10-13-22)18-32-15-5-2-6-16-32/h1,3-4,7-14,17,25H,2,5-6,15-16,18H2,(H2,29,33)(H,31,34) QMPQJWQHTDPWNU-UHFFFAOYSA-N 50279044 (Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenylamino)-methylene]-2,3-dihydro-1H-indole-6-carboxylic Acid Amide::CHEMBL497949 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm900431g 10.7270/Q2RB75JS 19522465 Roth, GJ; Heckel, A; Colbatzky, F; Handschuh, S; Kley, J; Lehmann-Lintz, T; Lotz, R; Tontsch-Grunt, U; Walter, R; Hilberg, F Boehringer Ingelheim Pharma GmbH & Co. KG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279044&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91493928 104121116 CHEMBL497949 ZINC00591101 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50882536 COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38) SWDINMTYJOBJBL-UHFFFAOYSA-N 50279080 (Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylicAcid Methyl Ester::CHEMBL502835::methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm900431g 10.7270/Q2RB75JS 19522465 Roth, GJ; Heckel, A; Colbatzky, F; Handschuh, S; Kley, J; Lehmann-Lintz, T; Lotz, R; Tontsch-Grunt, U; Walter, R; Hilberg, F Boehringer Ingelheim Pharma GmbH & Co. KG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279080&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 90914794 104121142 CHEMBL502835 ZINC22449469 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50882537 COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33) BQUCMYBIGNGMFC-UHFFFAOYSA-N 50279045 (Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-phenylamino}-phenyl-methylene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylicAcid Methyl Ester::CHEMBL525203 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm900431g 10.7270/Q2RB75JS 19522465 Roth, GJ; Heckel, A; Colbatzky, F; Handschuh, S; Kley, J; Lehmann-Lintz, T; Lotz, R; Tontsch-Grunt, U; Walter, R; Hilberg, F Boehringer Ingelheim Pharma GmbH & Co. KG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50279045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50279045&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91279111 104121117 CHEMBL525203 ZINC40430476 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50878934 Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1 InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35) UVUGBBNUQBSROH-UHFFFAOYSA-N 50264755 4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin-4-yl-1,2-benzisoxazol-6-yl)benzamide::4-methyl-N-(3-morpholinophenyl)-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)benzamide::CHEMBL485285 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264755&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 19B 3E93 9983303 104112664 CHEMBL485285 ZINC03938229 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50878944 Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1 InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33) NCEXHVFUAONAAE-UHFFFAOYSA-N 50265034 2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-morpholinophenyl)biphenyl-3-carboxamide::CHEMBL523559 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265034&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580420 104112852 CHEMBL523559 ZINC40429518 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50878954 Cc1ccc(NC(=O)c2ccnc(c2)N2CCCC2)cc1-c1ccc2c(noc2c1)C1CCNCC1 InChI=1S/C29H31N5O2/c1-19-4-6-23(32-29(35)22-10-13-31-27(17-22)34-14-2-3-15-34)18-25(19)21-5-7-24-26(16-21)36-33-28(24)20-8-11-30-12-9-20/h4-7,10,13,16-18,20,30H,2-3,8-9,11-12,14-15H2,1H3,(H,32,35) DMTJDVSGJMJVRQ-UHFFFAOYSA-N 50264756 CHEMBL485286::N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)phenyl)-2-(pyrrolidin-1-yl)isonicotinamide Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264756&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44580077 104112665 CHEMBL485286 ZINC40937453 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908001 CC(C)CC(=O)Nc1[nH]nc2c1CN(C(=O)C1CCN(C)CC1)C2(C)C InChI=1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25) HUXYBQXJVXOMKX-UHFFFAOYSA-N 50378657 CHEMBL1230607 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2010.01.042 10.7270/Q21R6RG5 20153204 Brasca, MG; Albanese, C; Alzani, R; Amici, R; Avanzi, N; Ballinari, D; Bischoff, J; Borghi, D; Casale, E; Croci, V; Fiorentini, F; Isacchi, A; Mercurio, C; Nesi, M; Orsini, P; Pastori, W; Pesenti, E; Pevarello, P; Roussel, P; Varasi, M; Volpi, D; Vulpetti, A; Ciomei, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378657&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46191454 160857740 CHEMBL1230607 ZINC52509437 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918886 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(c4-c3n2)C(c2ccccc2)(c2ccccc2)c2ccccc2)C(N)=O)c1 InChI=1S/C41H37F3N8O2/c1-50-21-23-51(24-22-50)31-18-20-34(54-41(42,43)44)33(25-31)47-39-46-26-27-17-19-32-36(38(45)53)49-52(37(32)35(27)48-39)40(28-11-5-2-6-12-28,29-13-7-3-8-14-29)30-15-9-4-10-16-30/h2-16,18,20,25-26H,17,19,21-24H2,1H3,(H2,45,53)(H,46,47,48) ASPGNMNPVXBVLZ-UHFFFAOYSA-N 50329925 8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-trityl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1269489 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329925&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52945276 123109040 CHEMBL1269489 ZINC72147857 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918917 COc1ccc(Cn2nc(C(N)=O)c3CCc4cnc(Nc5cc(ccc5OC(F)(F)F)N5CCNCC5)nc4-c23)cc1 InChI=1S/C29H29F3N8O3/c1-42-20-6-2-17(3-7-20)16-40-26-21(25(38-40)27(33)41)8-4-18-15-35-28(37-24(18)26)36-22-14-19(39-12-10-34-11-13-39)5-9-23(22)43-29(30,31)32/h2-3,5-7,9,14-15,34H,4,8,10-13,16H2,1H3,(H2,33,41)(H,35,36,37) TXYKZQNORAPDGI-UHFFFAOYSA-N 50329918 1-(4-methoxybenzyl)-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1269490 Serine/threonine-protein kinase PLK1 Homo sapiens 2650 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329918&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52944273 123109033 CHEMBL1269490 ZINC64513932 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918918 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)[N+]4([O-])CC[N+](C)([O-])CC4)nc3-c12 InChI=1S/C23H25F3N8O4/c1-32-20-15(19(31-32)21(27)35)5-3-13-12-28-22(30-18(13)20)29-16-11-14(4-6-17(16)38-23(24,25)26)34(37)9-7-33(2,36)8-10-34/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,27,35)(H,28,29,30) NVYUAAKYNALZJZ-UHFFFAOYSA-N 50329919 1-(3-(3-carbamoyl-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-ylamino)-4-(trifluoromethoxy)phenyl)-4-methylpiperazine 1,4-dioxide::CHEMBL1271694 Serine/threonine-protein kinase PLK1 Homo sapiens 2682 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52947965 123109034 CHEMBL1271694 ZINC64539075 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918924 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C23H25F3N8O2/c1-32-7-9-34(10-8-32)14-4-6-17(36-23(24,25)26)16(11-14)29-22-28-12-13-3-5-15-19(21(27)35)31-33(2)20(15)18(13)30-22/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,27,35)(H,28,29,30) VEFDUZNTHFBSFU-UHFFFAOYSA-N 50329914 1-methyl-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272140 Serine/threonine-protein kinase PLK1 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24825755 123109029 CHEMBL1272140 ZINC43196882 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918925 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(n[nH]c4C(N)=O)-c3n2)c1 InChI=1S/C22H23F3N8O2/c1-32-6-8-33(9-7-32)13-3-5-16(35-22(23,24)25)15(10-13)28-21-27-11-12-2-4-14-18(17(12)29-21)30-31-19(14)20(26)34/h3,5,10-11H,2,4,6-9H2,1H3,(H2,26,34)(H,30,31)(H,27,28,29) LEBAFGAECYWBLA-UHFFFAOYSA-N 50329926 8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271695 Serine/threonine-protein kinase PLK1 Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329926&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56668250 123109041 CHEMBL1271695 ZINC70690074 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918926 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCNCC4)nc3-c12 InChI=1S/C22H23F3N8O2/c1-32-19-14(18(31-32)20(26)34)4-2-12-11-28-21(30-17(12)19)29-15-10-13(33-8-6-27-7-9-33)3-5-16(15)35-22(23,24)25/h3,5,10-11,27H,2,4,6-9H2,1H3,(H2,26,34)(H,28,29,30) TUWAYASUNDRSML-UHFFFAOYSA-N 50329915 1-methyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271644 Serine/threonine-protein kinase PLK1 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50899254 123109030 CHEMBL1271644 ZINC43196884 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918935 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCF)c4-c3n2)C(N)=O)c1 InChI=1S/C24H26F4N8O2/c1-34-8-10-35(11-9-34)15-3-5-18(38-24(26,27)28)17(12-15)31-23-30-13-14-2-4-16-20(22(29)37)33-36(7-6-25)21(16)19(14)32-23/h3,5,12-13H,2,4,6-11H2,1H3,(H2,29,37)(H,30,31,32) VPWDLLHGBJTELF-UHFFFAOYSA-N 50329913 1-(2-fluoroethyl)-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271751 Serine/threonine-protein kinase PLK1 Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329913&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56675140 123109028 CHEMBL1271751 ZINC43196886 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918936 CCn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 InChI=1S/C24H27F3N8O2/c1-3-35-21-16(20(32-35)22(28)36)6-4-14-13-29-23(31-19(14)21)30-17-12-15(34-10-8-33(2)9-11-34)5-7-18(17)37-24(25,26)27/h5,7,12-13H,3-4,6,8-11H2,1-2H3,(H2,28,36)(H,29,30,31) GQHQUZYTXNFEHP-UHFFFAOYSA-N 50329927 1-ethyl-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271752 Serine/threonine-protein kinase PLK1 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329927&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56664839 123109042 CHEMBL1271752 ZINC70690079 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918937 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C=C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H25F3N8O2/c1-3-35-21-16(20(32-35)22(28)36)6-4-14-13-29-23(31-19(14)21)30-17-12-15(34-10-8-33(2)9-11-34)5-7-18(17)37-24(25,26)27/h3,5,7,12-13H,1,4,6,8-11H2,2H3,(H2,28,36)(H,29,30,31) IWNBRVJHAXKTLL-UHFFFAOYSA-N 50329929 8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-vinyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271870 Serine/threonine-protein kinase PLK1 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329929&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56657856 123109044 CHEMBL1271870 ZINC43196883 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918938 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCCl)c4-c3n2)C(N)=O)c1 InChI=1S/C24H26ClF3N8O2/c1-34-8-10-35(11-9-34)15-3-5-18(38-24(26,27)28)17(12-15)31-23-30-13-14-2-4-16-20(22(29)37)33-36(7-6-25)21(16)19(14)32-23/h3,5,12-13H,2,4,6-11H2,1H3,(H2,29,37)(H,30,31,32) OCPMRHZHACWECI-UHFFFAOYSA-N 50329916 1-(2-chloroethyl)-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271869 Serine/threonine-protein kinase PLK1 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329916&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56681780 123109031 CHEMBL1271869 ZINC70690070 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908036 CC(C)(C)C(=O)N1Cc2c(NC(=O)c3cc(F)cc(F)c3)[nH]nc2C1(C)C InChI=1S/C19H22F2N4O2/c1-18(2,3)17(27)25-9-13-14(19(25,4)5)23-24-15(13)22-16(26)10-6-11(20)8-12(21)7-10/h6-8H,9H2,1-5H3,(H2,22,23,24,26) QXBKFUBBGBWPCJ-UHFFFAOYSA-N 50307987 CHEMBL604712::N-[5-(2,2-Dimethylpropanoyl)-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-3,5-difluorobenzamide Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2010.01.042 10.7270/Q21R6RG5 20153204 Brasca, MG; Albanese, C; Alzani, R; Amici, R; Avanzi, N; Ballinari, D; Bischoff, J; Borghi, D; Casale, E; Croci, V; Fiorentini, F; Isacchi, A; Mercurio, C; Nesi, M; Orsini, P; Pastori, W; Pesenti, E; Pevarello, P; Roussel, P; Varasi, M; Volpi, D; Vulpetti, A; Ciomei, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50307987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50307987&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10429593 104162348 CHEMBL604712 ZINC38827189 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50910556 Cc1cc(NC(=O)Nc2ncc(CCNc3cc(Nc4nnc[nH]4)ncn3)s2)c(o1)C(F)(F)F InChI=1S/C18H17F3N10O2S/c1-9-4-11(14(33-9)18(19,20)21)28-16(32)30-17-23-6-10(34-17)2-3-22-12-5-13(25-7-24-12)29-15-26-8-27-31-15/h4-8H,2-3H2,1H3,(H2,23,28,30,32)(H3,22,24,25,26,27,29,31) KNTGXMNWVXZIMW-UHFFFAOYSA-N 50314075 1-(5-(2-(6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-ylamino)ethyl)thiazol-2-yl)-3-(5-methyl-2-(trifluoromethyl)furan-3-yl)urea::1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea::CHEMBL1092830 Serine/threonine-protein kinase PLK1 Homo sapiens 720 ChEMBL 10.1021/jm901443h 10.7270/Q2XP75W8 20000735 Zuccotto, F; Ardini, E; Casale, E; Angiolini, M Nerviano Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314075&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24875313 104148436 CHEMBL1092830 ZINC34285233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918939 CCN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O2/c1-3-34-8-10-35(11-9-34)15-5-7-18(37-24(25,26)27)17(12-15)30-23-29-13-14-4-6-16-20(22(28)36)32-33(2)21(16)19(14)31-23/h5,7,12-13H,3-4,6,8-11H2,1-2H3,(H2,28,36)(H,29,30,31) JKMYPJAZMANXBX-UHFFFAOYSA-N 50329921 8-(5-(4-ethylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271590 Serine/threonine-protein kinase PLK1 Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329921&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52943310 123109036 CHEMBL1271590 ZINC64513639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918940 COCCn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 InChI=1S/C25H29F3N8O3/c1-34-7-9-35(10-8-34)16-4-6-19(39-25(26,27)28)18(13-16)31-24-30-14-15-3-5-17-21(23(29)37)33-36(11-12-38-2)22(17)20(15)32-24/h4,6,13-14H,3,5,7-12H2,1-2H3,(H2,29,37)(H,30,31,32) ALDLYIYZAMAOJM-UHFFFAOYSA-N 50329928 1-(2-methoxyethyl)-8-(5-(piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271812 Serine/threonine-protein kinase PLK1 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329928&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56657855 123109043 CHEMBL1271812 ZINC72135031 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918941 CN1CCCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O2/c1-33-8-3-9-35(11-10-33)15-5-7-18(37-24(25,26)27)17(12-15)30-23-29-13-14-4-6-16-20(22(28)36)32-34(2)21(16)19(14)31-23/h5,7,12-13H,3-4,6,8-11H2,1-2H3,(H2,28,36)(H,29,30,31) UYAHRXNGFXMMIC-UHFFFAOYSA-N 50329923 1-methyl-8-(5-(4-methyl-1,4-diazepan-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272195 Serine/threonine-protein kinase PLK1 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329923&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52945523 123109038 CHEMBL1272195 ZINC64526796 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918943 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCC(CC4)N4CCCC4)nc3-c12 InChI=1S/C27H31F3N8O2/c1-36-24-19(23(35-36)25(31)39)6-4-16-15-32-26(34-22(16)24)33-20-14-18(5-7-21(20)40-27(28,29)30)38-12-8-17(9-13-38)37-10-2-3-11-37/h5,7,14-15,17H,2-4,6,8-13H2,1H3,(H2,31,39)(H,32,33,34) WTGYPEXVSDUQOV-UHFFFAOYSA-N 50329924 1-methyl-8-(5-(4-(pyrrolidin-1-yl)piperidin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272250 Serine/threonine-protein kinase PLK1 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329924&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52945929 123109039 CHEMBL1272250 ZINC64527480 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918944 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(CC4)C(=O)N4CCNCC4)nc3-c12 InChI=1S/C27H31F3N10O3/c1-37-23-18(22(36-37)24(31)41)4-2-16-15-33-25(35-21(16)23)34-19-14-17(3-5-20(19)43-27(28,29)30)38-10-12-40(13-11-38)26(42)39-8-6-32-7-9-39/h3,5,14-15,32H,2,4,6-13H2,1H3,(H2,31,41)(H,33,34,35) IBSIAJWPXJVSHB-UHFFFAOYSA-N 50329933 1-methyl-8-(5-(4-(piperazine-1-carbonyl)piperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1269488 Serine/threonine-protein kinase PLK1 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329933&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52940661 123109048 CHEMBL1269488 ZINC64528326 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918945 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(N)ccc4OC(F)(F)F)nc3-c12 InChI=1S/C18H16F3N7O2/c1-28-15-10(14(27-28)16(23)29)4-2-8-7-24-17(26-13(8)15)25-11-6-9(22)3-5-12(11)30-18(19,20)21/h3,5-7H,2,4,22H2,1H3,(H2,23,29)(H,24,25,26) NCDFJOWBEBTLBV-UHFFFAOYSA-N 50329931 8-(5-amino-2-(trifluoromethoxy)phenylamino)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1269042 Serine/threonine-protein kinase PLK1 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52943186 123109046 CHEMBL1269042 ZINC64526467 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918946 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(NC5CCNC5)ccc4OC(F)(F)F)nc3-c12 InChI=1S/C22H23F3N8O2/c1-33-19-14(18(32-33)20(26)34)4-2-11-9-28-21(31-17(11)19)30-15-8-12(29-13-6-7-27-10-13)3-5-16(15)35-22(23,24)25/h3,5,8-9,13,27,29H,2,4,6-7,10H2,1H3,(H2,26,34)(H,28,30,31) VDGKVVOABLGJEI-UHFFFAOYSA-N 50329934 1-methyl-8-(5-(pyrrolidin-3-ylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271591 Serine/threonine-protein kinase PLK1 Homo sapiens 77 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329934&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52946976 123109049 CHEMBL1271591 ZINC64513652 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918948 Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4OC(F)(F)F)nc3-c12 InChI=1S/C18H15F3N6O2/c1-27-15-10(14(26-27)16(22)28)7-6-9-8-23-17(25-13(9)15)24-11-4-2-3-5-12(11)29-18(19,20)21/h2-5,8H,6-7H2,1H3,(H2,22,28)(H,23,24,25) GCFCQBCBKXQUCD-UHFFFAOYSA-N 50329932 1-methyl-8-(2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272089 Serine/threonine-protein kinase PLK1 Homo sapiens 117 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52947958 123109047 CHEMBL1272089 ZINC64512419 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918949 CN1CCCC1CCNc1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C25H29F3N8O2/c1-35-11-3-4-16(35)9-10-30-15-6-8-19(38-25(26,27)28)18(12-15)32-24-31-13-14-5-7-17-21(23(29)37)34-36(2)22(17)20(14)33-24/h6,8,12-13,16,30H,3-5,7,9-11H2,1-2H3,(H2,29,37)(H,31,32,33) JVZPJOJXJIONKU-UHFFFAOYSA-N 50329935 1-methyl-8-(5-(2-(1-methylpyrrolidin-2-yl)ethylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271535 Serine/threonine-protein kinase PLK1 Homo sapiens 123 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329935&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52946971 123109050 CHEMBL1271535 ZINC64526301 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918950 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CC[N+](C)([O-])CC4)nc3-c12 InChI=1S/C23H25F3N8O3/c1-32-20-15(19(31-32)21(27)35)5-3-13-12-28-22(30-18(13)20)29-16-11-14(4-6-17(16)37-23(24,25)26)33-7-9-34(2,36)10-8-33/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,27,35)(H,28,29,30) WDYNAWBNNIUDEQ-UHFFFAOYSA-N 50329917 4-(3-(3-carbamoyl-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-ylamino)-4-(trifluoromethoxy)phenyl)-1-methylpiperazine 1-oxide::CHEMBL1271645 Serine/threonine-protein kinase PLK1 Homo sapiens 127 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329917&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52946706 123109032 CHEMBL1271645 ZINC64528260 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918954 CN1CCC(CC1)Nc1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O2/c1-34-9-7-14(8-10-34)30-15-4-6-18(37-24(25,26)27)17(11-15)31-23-29-12-13-3-5-16-20(22(28)36)33-35(2)21(16)19(13)32-23/h4,6,11-12,14,30H,3,5,7-10H2,1-2H3,(H2,28,36)(H,29,31,32) WNSIYZQLZXMELB-UHFFFAOYSA-N 50329922 1-methyl-8-(5-(1-methylpiperidin-4-ylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1272300 Serine/threonine-protein kinase PLK1 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329922&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52942317 123109037 CHEMBL1272300 ZINC64513819 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918965 Cn1nc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(CC4)C(=O)OC(C)(C)C)nc3-c12 InChI=1S/C27H31F3N8O4/c1-26(2,3)42-25(40)38-11-9-37(10-12-38)16-6-8-19(41-27(28,29)30)18(13-16)33-24-32-14-15-5-7-17-21(23(31)39)35-36(4)22(17)20(15)34-24/h6,8,13-14H,5,7,9-12H2,1-4H3,(H2,31,39)(H,32,33,34) QANJTFCNOSLQBM-UHFFFAOYSA-N 50329930 CHEMBL1269487::tert-butyl 4-(3-(3-carbamoyl-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazolin-8-ylamino)-4-(trifluoromethoxy)phenyl)piperazine-1-carboxylate Serine/threonine-protein kinase PLK1 Homo sapiens 859 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52944272 123109045 CHEMBL1269487 ZINC64528325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50918966 CN1C(C)(C)CC(CC1(C)C)Nc1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1 InChI=1S/C28H35F3N8O2/c1-26(2)12-17(13-27(3,4)39(26)6)34-16-8-10-20(41-28(29,30)31)19(11-16)35-25-33-14-15-7-9-18-22(24(32)40)37-38(5)23(18)21(15)36-25/h8,10-11,14,17,34H,7,9,12-13H2,1-6H3,(H2,32,40)(H,33,35,36) FRMVCJCLNSUJSR-UHFFFAOYSA-N 50329920 1-methyl-8-(5-(1,2,2,6,6-pentamethylpiperidin-4-ylamino)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1271482 Serine/threonine-protein kinase PLK1 Homo sapiens 964 ChEMBL 10.1016/j.bmcl.2010.09.060 10.7270/Q2VT1T39 20932759 Beria, I; Valsasina, B; Brasca, MG; Ceccarelli, W; Colombo, M; Cribioli, S; Fachin, G; Ferguson, RD; Fiorentini, F; Gianellini, LM; Giorgini, ML; Moll, JK; Posteri, H; Pezzetta, D; Roletto, F; Sola, F; Tesei, D; Caruso, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329920&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52943243 123109035 CHEMBL1271482 ZINC64513209 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908336 O=C1Cc2cnc(Nc3ccccc3)nc2-c2ccccc2N1 InChI=1S/C18H14N4O/c23-16-10-12-11-19-18(20-13-6-2-1-3-7-13)22-17(12)14-8-4-5-9-15(14)21-16/h1-9,11H,10H2,(H,21,23)(H,19,20,22) IAKSXYZIQGVUIF-UHFFFAOYSA-N 50308225 2-Anilino-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL603255 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308225&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379344 104162586 CHEMBL603255 ZINC45385115 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908337 Ic1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C18H13IN4O/c19-12-5-7-13(8-6-12)21-18-20-10-11-9-16(24)22-15-4-2-1-3-14(15)17(11)23-18/h1-8,10H,9H2,(H,22,24)(H,20,21,23) WTINBRGDWRUTBK-UHFFFAOYSA-N 50308226 2-(4-Iodoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL598024 Serine/threonine-protein kinase PLK1 Homo sapiens 15000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308226&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379345 104162587 CHEMBL598024 ZINC45365644 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908338 COc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C19H16N4O2/c1-25-14-8-6-13(7-9-14)21-19-20-11-12-10-17(24)22-16-5-3-2-4-15(16)18(12)23-19/h2-9,11H,10H2,1H3,(H,22,24)(H,20,21,23) NNGKQEUOVPXDNB-UHFFFAOYSA-N 50308227 2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL598025 Serine/threonine-protein kinase PLK1 Homo sapiens 47000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308227&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379346 104162588 CHEMBL598025 ZINC45366152 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908339 Clc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C18H13ClN4O/c19-12-5-7-13(8-6-12)21-18-20-10-11-9-16(24)22-15-4-2-1-3-14(15)17(11)23-18/h1-8,10H,9H2,(H,22,24)(H,20,21,23) OROJQWVRCGJACT-UHFFFAOYSA-N 50308228 2-(4-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL596807 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308228&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379347 104162589 CHEMBL596807 ZINC45357749 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908340 [O-][N+](=O)c1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C18H13N5O3/c24-16-9-11-10-19-18(20-12-5-7-13(8-6-12)23(25)26)22-17(11)14-3-1-2-4-15(14)21-16/h1-8,10H,9H2,(H,21,24)(H,19,20,22) FGDNDXCDDSSOBV-UHFFFAOYSA-N 50308229 2-(4-Nitroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL596808 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308229&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379490 104162590 CHEMBL596808 ZINC45357752 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908341 Cc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C19H16N4O/c1-12-6-8-14(9-7-12)21-19-20-11-13-10-17(24)22-16-5-3-2-4-15(16)18(13)23-19/h2-9,11H,10H2,1H3,(H,22,24)(H,20,21,23) OLCKDNOSPFOVAT-UHFFFAOYSA-N 50308230 2-(4-Methylanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL605324 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308230&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379491 104162591 CHEMBL605324 ZINC45391671 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908342 Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C18H14N4O2/c23-13-7-5-12(6-8-13)20-18-19-10-11-9-16(24)21-15-4-2-1-3-14(15)17(11)22-18/h1-8,10,23H,9H2,(H,21,24)(H,19,20,22) UJPRBQDQQHDOGH-UHFFFAOYSA-N 50308231 2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL605841 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308231&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379492 104162592 CHEMBL605841 ZINC45390552 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908343 Brc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C18H13BrN4O/c19-12-5-7-13(8-6-12)21-18-20-10-11-9-16(24)22-15-4-2-1-3-14(15)17(11)23-18/h1-8,10H,9H2,(H,22,24)(H,20,21,23) DALMTQZETHVZCO-UHFFFAOYSA-N 50308232 2-(4-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL597586 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308232&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379493 104162593 CHEMBL597586 ZINC45364464 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908344 CCOc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1 InChI=1S/C20H18N4O2/c1-2-26-15-9-7-14(8-10-15)22-20-21-12-13-11-18(25)23-17-6-4-3-5-16(17)19(13)24-20/h3-10,12H,2,11H2,1H3,(H,23,25)(H,21,22,24) SWJLVNUYMOUHRA-UHFFFAOYSA-N 50308224 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL606410 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308224&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379494 104162585 CHEMBL606410 ZINC45384908 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908345 Oc1cccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)c1 InChI=1S/C18H14N4O2/c23-13-5-3-4-12(9-13)20-18-19-10-11-8-16(24)21-15-7-2-1-6-14(15)17(11)22-18/h1-7,9-10,23H,8H2,(H,21,24)(H,19,20,22) CCNSBMQGGRYSOB-UHFFFAOYSA-N 50308184 2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL604545 Serine/threonine-protein kinase PLK1 Homo sapiens 19000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308184&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379495 104162545 CHEMBL604545 ZINC45385893 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908346 Clc1ccccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1 InChI=1S/C18H13ClN4O/c19-13-6-2-4-8-15(13)22-18-20-10-11-9-16(24)21-14-7-3-1-5-12(14)17(11)23-18/h1-8,10H,9H2,(H,21,24)(H,20,22,23) UOPUPFLUHAWAOV-UHFFFAOYSA-N 50308185 2-(2-Chloroanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL599844 Serine/threonine-protein kinase PLK1 Homo sapiens 73000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308185&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379496 104162546 CHEMBL599844 ZINC45367821 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908347 Brc1ccccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1 InChI=1S/C18H13BrN4O/c19-13-6-2-4-8-15(13)22-18-20-10-11-9-16(24)21-14-7-3-1-5-12(14)17(11)23-18/h1-8,10H,9H2,(H,21,24)(H,20,22,23) SPGJVHVPLQMJKD-UHFFFAOYSA-N 50308186 2-(2-Bromoanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL599027 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308186&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379605 104162547 CHEMBL599027 ZINC45358379 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908348 Oc1ccccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1 InChI=1S/C18H14N4O2/c23-15-8-4-3-7-14(15)21-18-19-10-11-9-16(24)20-13-6-2-1-5-12(13)17(11)22-18/h1-8,10,23H,9H2,(H,20,24)(H,19,21,22) GUFPGPJITLCTNE-UHFFFAOYSA-N 50308187 2-(2-Hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL603545 Serine/threonine-protein kinase PLK1 Homo sapiens 14000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308187&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379606 104162548 CHEMBL603545 ZINC45392539 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908349 COc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1O InChI=1S/C19H16N4O3/c1-26-16-7-6-12(9-15(16)24)21-19-20-10-11-8-17(25)22-14-5-3-2-4-13(14)18(11)23-19/h2-7,9-10,24H,8H2,1H3,(H,22,25)(H,20,21,23) SRLAWDYDLHMAMZ-UHFFFAOYSA-N 50308188 2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d]-[1]benzazepin-6-one::CHEMBL603463 Serine/threonine-protein kinase PLK1 Homo sapiens 5700 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308188&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16730105 104162549 CHEMBL603463 ZINC45389131 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908350 Oc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1Cl InChI=1S/C18H13ClN4O2/c19-13-8-11(5-6-15(13)24)21-18-20-9-10-7-16(25)22-14-4-2-1-3-12(14)17(10)23-18/h1-6,8-9,24H,7H2,(H,22,25)(H,20,21,23) NKTDDFFCFNHRMA-UHFFFAOYSA-N 50308189 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benz-azepin-6-one::CHEMBL598000 Serine/threonine-protein kinase PLK1 Homo sapiens 9300 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308189&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379607 104162550 CHEMBL598000 ZINC45356921 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908351 Cc1cc(O)ccc1Nc1ncc2CC(=O)Nc3ccccc3-c2n1 InChI=1S/C19H16N4O2/c1-11-8-13(24)6-7-15(11)22-19-20-10-12-9-17(25)21-16-5-3-2-4-14(16)18(12)23-19/h2-8,10,24H,9H2,1H3,(H,21,25)(H,20,22,23) CDACNIVVKYXGBO-UHFFFAOYSA-N 50308190 2-(4-Hydroxy-2-methylanilino)-5,7-dihydro-6H-pyrimido[5,4-d]-[1]benzazepin-6-one::CHEMBL598201 Serine/threonine-protein kinase PLK1 Homo sapiens 20000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308190&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379608 104162551 CHEMBL598201 ZINC45357460 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908352 COc1ccc-2c(NC(=O)Cc3cnc(Nc4ccc(O)cc4)nc-23)c1 InChI=1S/C19H16N4O3/c1-26-14-6-7-15-16(9-14)22-17(25)8-11-10-20-19(23-18(11)15)21-12-2-4-13(24)5-3-12/h2-7,9-10,24H,8H2,1H3,(H,22,25)(H,20,21,23) IRDQZYNDOWVJIZ-UHFFFAOYSA-N 50308191 2-(4-Hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL598418 Serine/threonine-protein kinase PLK1 Homo sapiens 750 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308191&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379610 104162552 CHEMBL598418 ZINC45355380 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908353 COc1ccc(Nc2ncc3CC(=O)Nc4cc(OC)ccc4-c3n2)cc1 InChI=1S/C20H18N4O3/c1-26-14-5-3-13(4-6-14)22-20-21-11-12-9-18(25)23-17-10-15(27-2)7-8-16(17)19(12)24-20/h3-8,10-11H,9H2,1-2H3,(H,23,25)(H,21,22,24) SKCATAJFICHYLV-UHFFFAOYSA-N 50308192 2-(4-Methoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL606395 Serine/threonine-protein kinase PLK1 Homo sapiens 350 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308192&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379609 104162553 CHEMBL606395 ZINC45386128 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908354 CCOc1ccc(Nc2ncc3CC(=O)Nc4cc(OC)ccc4-c3n2)cc1 InChI=1S/C21H20N4O3/c1-3-28-15-6-4-14(5-7-15)23-21-22-12-13-10-19(26)24-18-11-16(27-2)8-9-17(18)20(13)25-21/h4-9,11-12H,3,10H2,1-2H3,(H,24,26)(H,22,23,25) YOYKFXWWRVKLLS-UHFFFAOYSA-N 50308193 2-(4-Ethoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL597191 Serine/threonine-protein kinase PLK1 Homo sapiens 7300 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308193&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379611 104162554 CHEMBL597191 ZINC45366013 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908355 COc1ccc-2c(NC(=O)Cc3cnc(Nc4cccc(O)c4)nc-23)c1 InChI=1S/C19H16N4O3/c1-26-14-5-6-15-16(9-14)22-17(25)7-11-10-20-19(23-18(11)15)21-12-3-2-4-13(24)8-12/h2-6,8-10,24H,7H2,1H3,(H,22,25)(H,20,21,23) RCMAMGZVMIYCFL-UHFFFAOYSA-N 50308194 2-(3-Hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL604912 Serine/threonine-protein kinase PLK1 Homo sapiens 840 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308194&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379711 104162555 CHEMBL604912 ZINC45389311 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908356 COc1ccc-2c(NC(=O)Cc3cnc(Nc4ccc(OC)c(O)c4)nc-23)c1 InChI=1S/C20H18N4O4/c1-27-13-4-5-14-15(9-13)23-18(26)7-11-10-21-20(24-19(11)14)22-12-3-6-17(28-2)16(25)8-12/h3-6,8-10,25H,7H2,1-2H3,(H,23,26)(H,21,22,24) YTJXTZVLUBWOAJ-UHFFFAOYSA-N 50308195 2-(3-Hydroxy-4-methoxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL597393 Serine/threonine-protein kinase PLK1 Homo sapiens 140 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308195&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379712 104162556 CHEMBL597393 ZINC45365541 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908357 COc1ccc-2c(NC(=O)Cc3cnc(Nc4ccc(O)c(Cl)c4)nc-23)c1 InChI=1S/C19H15ClN4O3/c1-27-12-3-4-13-15(8-12)23-17(26)6-10-9-21-19(24-18(10)13)22-11-2-5-16(25)14(20)7-11/h2-5,7-9,25H,6H2,1H3,(H,23,26)(H,21,22,24) RHNQIPARHTZKOF-UHFFFAOYSA-N 50308196 2-(3-Chloro-4-hydroxyanilino)-9-methoxy-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one::CHEMBL597596 Serine/threonine-protein kinase PLK1 Homo sapiens 360 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308196&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379713 104162557 CHEMBL597596 ZINC45366067 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908358 Oc1ccc(Nc2ncc3CC(=O)Nc4ccncc4-c3n2)cc1 InChI=1S/C17H13N5O2/c23-12-3-1-11(2-4-12)20-17-19-8-10-7-15(24)21-14-5-6-18-9-13(14)16(10)22-17/h1-6,8-9,23H,7H2,(H,21,24)(H,19,20,22) ZXRAHJQYKWJFOQ-UHFFFAOYSA-N 50308197 2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one::CHEMBL597597 Serine/threonine-protein kinase PLK1 Homo sapiens 2600 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308197&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379715 104162558 CHEMBL597597 ZINC45366599 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908359 COc1ccc(Nc2ncc3CC(=O)Nc4ccncc4-c3n2)cc1 InChI=1S/C18H15N5O2/c1-25-13-4-2-12(3-5-13)21-18-20-9-11-8-16(24)22-15-6-7-19-10-14(15)17(11)23-18/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23) VFARZUBCMCBSIY-UHFFFAOYSA-N 50308198 2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one::CHEMBL596988 Serine/threonine-protein kinase PLK1 Homo sapiens 2500 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308198&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379714 104162559 CHEMBL596988 ZINC45366516 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908360 CCOc1ccc(Nc2ncc3CC(=O)Nc4ccncc4-c3n2)cc1 InChI=1S/C19H17N5O2/c1-2-26-14-5-3-13(4-6-14)22-19-21-10-12-9-17(25)23-16-7-8-20-11-15(16)18(12)24-19/h3-8,10-11H,2,9H2,1H3,(H,23,25)(H,21,22,24) CMNMWXJPOUQMBC-UHFFFAOYSA-N 50308199 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one::CHEMBL605118 Serine/threonine-protein kinase PLK1 Homo sapiens 1700 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308199&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379716 104162560 CHEMBL605118 ZINC45385961 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908361 Oc1cccc(Nc2ncc3CC(=O)Nc4ccncc4-c3n2)c1 InChI=1S/C17H13N5O2/c23-12-3-1-2-11(7-12)20-17-19-8-10-6-15(24)21-14-4-5-18-9-13(14)16(10)22-17/h1-5,7-9,23H,6H2,(H,21,24)(H,19,20,22) NFBRGEFBURVIHX-UHFFFAOYSA-N 50308200 2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one::CHEMBL602043 Serine/threonine-protein kinase PLK1 Homo sapiens 2300 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308200&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379717 104162561 CHEMBL602043 ZINC45368689 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908362 Oc1ccc(Nc2ncc3CC(=O)Nc4ccncc4-c3n2)cc1Cl InChI=1S/C17H12ClN5O2/c18-12-6-10(1-2-14(12)24)21-17-20-7-9-5-15(25)22-13-3-4-19-8-11(13)16(9)23-17/h1-4,6-8,24H,5H2,(H,22,25)(H,20,21,23) VCKGXGZVFOOGNC-UHFFFAOYSA-N 50308201 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrido[4,3-b]pyrimido[4,5-d]azepin-6-one::CHEMBL599446 Serine/threonine-protein kinase PLK1 Homo sapiens 1400 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308201&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379811 104162562 CHEMBL599446 ZINC45368437 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908363 Oc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1 InChI=1S/C17H13N5O2/c23-12-5-3-11(4-6-12)20-17-19-9-10-8-14(24)21-13-2-1-7-18-16(13)15(10)22-17/h1-7,9,23H,8H2,(H,21,24)(H,19,20,22) FZJNFTXYFQWNGH-UHFFFAOYSA-N 50308202 2-(4-Hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one::CHEMBL598633 Serine/threonine-protein kinase PLK1 Homo sapiens 55000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308202&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379813 104162563 CHEMBL598633 ZINC45354956 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908364 COc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1 InChI=1S/C18H15N5O2/c1-25-13-6-4-12(5-7-13)21-18-20-10-11-9-15(24)22-14-3-2-8-19-17(14)16(11)23-18/h2-8,10H,9H2,1H3,(H,22,24)(H,20,21,23) ZHHMMZHUDGUJKT-UHFFFAOYSA-N 50308203 2-(4-Methoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one::CHEMBL606255 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308203&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379812 104162564 CHEMBL606255 ZINC45375008 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908365 CCOc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1 InChI=1S/C19H17N5O2/c1-2-26-14-7-5-13(6-8-14)22-19-21-11-12-10-16(25)23-15-4-3-9-20-18(15)17(12)24-19/h3-9,11H,2,10H2,1H3,(H,23,25)(H,21,22,24) LXRFOXKXUGKQGV-UHFFFAOYSA-N 50308204 2-(4-Ethoxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one::CHEMBL598837 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308204&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379814 104162565 CHEMBL598837 ZINC45364114 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908366 Oc1cccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)c1 InChI=1S/C17H13N5O2/c23-12-4-1-3-11(8-12)20-17-19-9-10-7-14(24)21-13-5-2-6-18-16(13)15(10)22-17/h1-6,8-9,23H,7H2,(H,21,24)(H,19,20,22) DKMQQYBCJVFNRW-UHFFFAOYSA-N 50308205 2-(3-Hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one::CHEMBL606185 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308205&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379815 104162566 CHEMBL606185 ZINC45384829 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908367 Oc1ccc(Nc2ncc3CC(=O)Nc4cccnc4-c3n2)cc1Cl InChI=1S/C17H12ClN5O2/c18-11-7-10(3-4-13(11)24)21-17-20-8-9-6-14(25)22-12-2-1-5-19-16(12)15(9)23-17/h1-5,7-8,24H,6H2,(H,22,25)(H,20,21,23) PHOCQCHTHJNVPB-UHFFFAOYSA-N 50308206 2-(3-Chloro-4-hydroxyanilino)-5,7-dihydro-6H-pyrido[3,2-b]pyrimido[4,5-d]azepin-6-one::CHEMBL598431 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308206&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379816 104162567 CHEMBL598431 ZINC45357481 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908447 O=C1Cc2cnc3ccnn3c2-c2ccccc2N1 InChI=1S/C14H10N4O/c19-13-7-9-8-15-12-5-6-16-18(12)14(9)10-3-1-2-4-11(10)17-13/h1-6,8H,7H2,(H,17,19) GHQLQRRRVXWIFQ-UHFFFAOYSA-N 50308207 6,8-Dihydro-7H-pyrazolo[5',1':2,3]pyrimido[5,4-d][1]benzazepin-7-one::CHEMBL590769 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308207&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379062 104162568 CHEMBL590769 ZINC45338759 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908448 O=C1Cc2cnc3cc(nn3c2-c2ccccc2N1)-c1ccccc1 InChI=1S/C20H14N4O/c25-19-10-14-12-21-18-11-17(13-6-2-1-3-7-13)23-24(18)20(14)15-8-4-5-9-16(15)22-19/h1-9,11-12H,10H2,(H,22,25) ZTJVEYJKWKUOKL-UHFFFAOYSA-N 50308208 2-Phenyl-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimido[5,4-d][1]benzazepin-7-one::CHEMBL599247 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308208&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379063 104162569 CHEMBL599247 ZINC45358020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908449 COc1ccc-2c(NC(=O)Cc3cnc4ccnn4c-23)c1 InChI=1S/C15H12N4O2/c1-21-10-2-3-11-12(7-10)18-14(20)6-9-8-16-13-4-5-17-19(13)15(9)11/h2-5,7-8H,6H2,1H3,(H,18,20) JQVJMUZVMIBEMK-UHFFFAOYSA-N 50308209 10-Methoxy-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimido[5,4-d][1]benzazepin-7-one::CHEMBL599248 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308209&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379064 104162570 CHEMBL599248 ZINC45358022 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908450 COc1ccc-2c(NC(=O)Cc3cnc4cc(nn4c-23)-c2ccccc2)c1 InChI=1S/C21H16N4O2/c1-27-15-7-8-16-18(10-15)23-20(26)9-14-12-22-19-11-17(24-25(19)21(14)16)13-5-3-2-4-6-13/h2-8,10-12H,9H2,1H3,(H,23,26) JCVZSDHNGQFOMA-UHFFFAOYSA-N 50308210 10-Methoxy-2-phenyl-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimido[5,4-d][1]benzazepin-7-one::CHEMBL603259 Serine/threonine-protein kinase PLK1 Homo sapiens 17000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308210&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379199 104162571 CHEMBL603259 ZINC45385762 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908451 O=C1Cc2cnc3cc(nn3c2-c2cnccc2N1)-c1ccccc1 InChI=1S/C19H13N5O/c25-18-8-13-10-21-17-9-16(12-4-2-1-3-5-12)23-24(17)19(13)14-11-20-7-6-15(14)22-18/h1-7,9-11H,8H2,(H,22,25) ITUGUNWECVJZLD-UHFFFAOYSA-N 50308211 2-Phenyl-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimido[4,5-d]pyrido[4,3-b]azepin-7-one::CHEMBL598434 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308211&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379058 104162572 CHEMBL598434 ZINC45357945 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908452 O=C1Cc2cnc3ccnn3c2-c2ncccc2N1 InChI=1S/C13H9N5O/c19-11-6-8-7-15-10-3-5-16-18(10)13(8)12-9(17-11)2-1-4-14-12/h1-5,7H,6H2,(H,17,19) DORLTQBZDRMSDJ-UHFFFAOYSA-N 50308212 6,8-Dihydro-7H-pyrazolo[5',1':2,3]pyrimido[4,5-d]pyrido[3,2-b]azepin-7-one::CHEMBL591896 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308212&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379200 104162573 CHEMBL591896 ZINC45338812 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908453 O=C1Cc2cnc3cc(nn3c2-c2ncccc2N1)-c1ccccc1 InChI=1S/C19H13N5O/c25-17-9-13-11-21-16-10-15(12-5-2-1-3-6-12)23-24(16)19(13)18-14(22-17)7-4-8-20-18/h1-8,10-11H,9H2,(H,22,25) ILPCHNKRSJQFMS-UHFFFAOYSA-N 50308213 2-Phenyl-6,8-dihydro-7H-pyrazolo[5',1':2,3]pyrimido[4,5-d]pyrido[3,2-b]azepin-7-one::CHEMBL598435 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308213&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379201 104162574 CHEMBL598435 ZINC45357949 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908454 COc1ccc-2c(NC(=O)Cc3cnc4ncnn4c-23)c1 InChI=1S/C14H11N5O2/c1-21-9-2-3-10-11(5-9)18-12(20)4-8-6-15-14-16-7-17-19(14)13(8)10/h2-3,5-7H,4H2,1H3,(H,18,20) RQBYJKUVCSEATB-UHFFFAOYSA-N 50308214 10-Methoxy-6,8-dihydro-7H-[1,2,4]triazolo[5',1':2,3]pyrimido[5,4-d][1]benzazepin-7-one::CHEMBL597005 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308214&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379060 104162575 CHEMBL597005 ZINC45356768 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908455 O=C1Cc2cnc3ncnn3c2-c2ncccc2N1 InChI=1S/C12H8N6O/c19-9-4-7-5-14-12-15-6-16-18(12)11(7)10-8(17-9)2-1-3-13-10/h1-3,5-6H,4H2,(H,17,19) RKYGSKBRBRXTNU-UHFFFAOYSA-N 50308215 6,8-Dihydro-7H-pyrido[3,2-b][1,2,4]triazolo[5',1':2,3]pyrimido[4,5-d]azepin-7-one::CHEMBL608427 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308215&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379061 104162576 CHEMBL608427 ZINC45391789 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908456 O=C1Cc2cc3c(nc2-c2ccccc2N1)[nH]c(=O)[nH]c3=O InChI=1S/C15H10N4O3/c20-11-6-7-5-9-13(18-15(22)19-14(9)21)17-12(7)8-3-1-2-4-10(8)16-11/h1-5H,6H2,(H,16,20)(H2,17,18,19,21,22) YYPQQBSQLJLDHR-UHFFFAOYSA-N 50308216 7,12-Dihydro-5H-pyrimido[5',4':5,6]pyrido[3,2-d][1]benzazepine-6,9,11(10H)-trione::CHEMBL597207 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308216&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379202 104162577 CHEMBL597207 ZINC45356359 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908457 Cn1c2nc-3c(CC(=O)Nc4ccccc-34)cc2c(=O)n(C)c1=O InChI=1S/C17H14N4O3/c1-20-15-11(16(23)21(2)17(20)24)7-9-8-13(22)18-12-6-4-3-5-10(12)14(9)19-15/h3-7H,8H2,1-2H3,(H,18,22) DCTSRNCETNCNSR-UHFFFAOYSA-N 50308217 10,12-Dimethyl-7,12-dihydro-5H-pyrimido[5',4':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione::CHEMBL603481 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308217&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379203 104162578 CHEMBL603481 ZINC45392535 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908458 COc1ccc-2c(NC(=O)Cc3cc4c(nc-23)[nH]c(=O)[nH]c4=O)c1 InChI=1S/C16H12N4O4/c1-24-8-2-3-9-11(6-8)17-12(21)5-7-4-10-14(18-13(7)9)19-16(23)20-15(10)22/h2-4,6H,5H2,1H3,(H,17,21)(H2,18,19,20,22,23) MABGUQGQPIYNNB-UHFFFAOYSA-N 50308218 3-Methoxy-7,12-dihydro-5H-pyrimido[5',4':5,6]pyrido[3,2-d][1]benzazepine-6,9,11-(10H)-trione::CHEMBL599666 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308218&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379204 104162579 CHEMBL599666 ZINC45371936 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908459 COc1ccc-2c(NC(=O)Cc3cc4c(nc-23)n(C)c(=O)n(C)c4=O)c1 InChI=1S/C18H16N4O4/c1-21-16-12(17(24)22(2)18(21)25)6-9-7-14(23)19-13-8-10(26-3)4-5-11(13)15(9)20-16/h4-6,8H,7H2,1-3H3,(H,19,23) FTIKXKPOYVUJHY-UHFFFAOYSA-N 50308219 3-Methoxy-10,12-dimethyl-7,12-dihydro-5H-pyrimido[5',4':5,6]pyrido[3,2-d][1]benzazepine-6,9,11(10H)-trione::CHEMBL596598 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308219&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379205 104162580 CHEMBL596598 ZINC45356255 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908460 O=C1Cc2cc3c(nc2-c2cnccc2N1)[nH]c(=O)[nH]c3=O InChI=1S/C14H9N5O3/c20-10-4-6-3-7-12(18-14(22)19-13(7)21)17-11(6)8-5-15-2-1-9(8)16-10/h1-3,5H,4H2,(H,16,20)(H2,17,18,19,21,22) RFPRGIADDZBQOK-UHFFFAOYSA-N 50308220 7,12-Dihydro-5H-pyrido[4,3-b]pyrimido[5',4':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione::CHEMBL606119 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308220&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379340 104162581 CHEMBL606119 ZINC45390572 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908461 Cn1c2nc-3c(CC(=O)Nc4ccncc-34)cc2c(=O)n(C)c1=O InChI=1S/C16H13N5O3/c1-20-14-9(15(23)21(2)16(20)24)5-8-6-12(22)18-11-3-4-17-7-10(11)13(8)19-14/h3-5,7H,6H2,1-2H3,(H,18,22) PQTGBRHHAQAHFT-UHFFFAOYSA-N 50308221 10,12-Dimethyl-7,12-dihydro-5H-pyrido[4,3-b]pyrimido[5',4':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione::CHEMBL599055 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308221&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379341 104162582 CHEMBL599055 ZINC45365838 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908462 O=C1Cc2cc3c(nc2-c2ncccc2N1)[nH]c(=O)[nH]c3=O InChI=1S/C14H9N5O3/c20-9-5-6-4-7-12(18-14(22)19-13(7)21)17-10(6)11-8(16-9)2-1-3-15-11/h1-4H,5H2,(H,16,20)(H2,17,18,19,21,22) CKCJYQIHWMMOMR-UHFFFAOYSA-N 50308222 7,12-Dihydro-5H-pyrido[3,2-b]pyrimido[5',4':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione::CHEMBL610512 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308222&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379342 104162583 CHEMBL610512 ZINC45393293 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908463 Cn1c2nc-3c(CC(=O)Nc4cccnc-34)cc2c(=O)n(C)c1=O InChI=1S/C16H13N5O3/c1-20-14-9(15(23)21(2)16(20)24)6-8-7-11(22)18-10-4-3-5-17-13(10)12(8)19-14/h3-6H,7H2,1-2H3,(H,18,22) LETMVVXGKMZTGX-UHFFFAOYSA-N 50308223 10,12-Dimethyl-7,12-dihydro-5H-pyrido[3,2-b]pyrimido[5',4':5,6]pyrido[2,3-d]azepine-6,9,11(10H)-trione::CHEMBL599056 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308223&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 45379343 104162584 CHEMBL599056 ZINC45366301 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50908465 Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1 InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) QQUXFYAWXPMDOE-UHFFFAOYSA-N 7266 14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,17}]octadeca-1(11),2,4,6,12(17),13,15-heptaen-9-one::9-bromopaullone::CHEMBL296586::Kenpaullone::NSC 664704::Paullone Analog 5::cid_3820 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm901388c 10.7270/Q24J0G22 20170163 Egert-Schmidt, AM; Dreher, J; Dunkel, U; Kohfeld, S; Preu, L; Weber, H; Ehlert, JE; Mutschler, B; Totzke, F; Schachtele, C; Kubbutat, MH; Baumann, K; Kunick, C Technische Universitat Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7266&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3820 8036822 CHEMBL296586 6000 ZINC01639355 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50917062 O=C1NCCc2[nH]c(cc12)-c1ccncc1 InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) DKXHSOUZPMHNIZ-UHFFFAOYSA-N 27344 2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyridin-4-one::JMC502647 Compound 8::Pyrrolopyridinone, 1 Serine/threonine-protein kinase PLK1 Homo sapiens 980 ChEMBL 10.1038/nchembio.90 10.7270/Q2DV1KVK 18469809 Montagnoli, A; Valsasina, B; Croci, V; Menichincheri, M; Rainoldi, S; Marchesi, V; Tibolla, M; Tenca, P; Brotherton, D; Albanese, C; Patton, V; Alzani, R; Ciavolella, A; Sola, F; Molinari, A; Volpi, D; Avanzi, N; Fiorentini, F; Cattoni, M; Healy, S; Ballinari, D; Pesenti, E; Isacchi, A; Moll, J; Bensimon, A; Vanotti, E; Santocanale, C Nerviano Medical Sciences Oncology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27344&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 0SY 4F9B 11715767 57299053 ZINC16052718 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50910062 Cn1cc(C2=C(C(=O)NC2=O)c2cccc(NCC(O)CO)c2)c2cc(F)ccc12 InChI=1S/C22H20FN3O4/c1-26-10-17(16-8-13(23)5-6-18(16)26)20-19(21(29)25-22(20)30)12-3-2-4-14(7-12)24-9-15(28)11-27/h2-8,10,15,24,27-28H,9,11H2,1H3,(H,25,29,30) RPGZQOOZHIEPJW-UHFFFAOYSA-N 50312990 (R,S)-3-(3-(2,3-dihydroxypropylamino)phenyl)-4-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione::CHEMBL1082152 Serine/threonine-protein kinase PLK1 Homo sapiens 23000 ChEMBL 10.1016/j.bmcl.2010.01.038 10.7270/Q2ZK5HNS 20138512 Gong, L; Hirschfeld, D; Tan, YC; Heather Hogg, J; Peltz, G; Avnur, Z; Dunten, P Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312990&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search DFN 1R0E 11560568 104147351 CHEMBL1082152 3502 ZINC12501080 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50910153 COc1ccc(cc1)-c1[nH][nH]c(=O)c1N=Nc1cccc(OC)c1 InChI=1S/C17H16N4O3/c1-23-13-8-6-11(7-9-13)15-16(17(22)21-19-15)20-18-12-4-3-5-14(10-12)24-2/h3-10H,1-2H3,(H2,19,21,22) AXEQDNRVEUBEKN-UHFFFAOYSA-N 50313050 (Z)-3-(4-methoxyphenyl)-4-(2-(3-methoxyphenyl)hydrazono)-1H-pyrazol-5(4H)-one::CHEMBL1080902 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2010.01.072 10.7270/Q2TX3G9B 20138514 Arnost, M; Pierce, A; ter Haar, E; Lauffer, D; Madden, J; Tanner, K; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313050&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46865325 104147411 CHEMBL1080902 ZINC49033769 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50910165 COc1ccc(cc1)-c1[nH][nH]c(=O)c1N=Nc1cccnc1 InChI=1S/C15H13N5O2/c1-22-12-6-4-10(5-7-12)13-14(15(21)20-18-13)19-17-11-3-2-8-16-9-11/h2-9H,1H3,(H2,18,20,21) KRHWSBXYWJHICK-UHFFFAOYSA-N 50313051 (Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazono)-1H-pyrazol-5(4H)-one::CHEMBL1076721 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2010.01.072 10.7270/Q2TX3G9B 20138514 Arnost, M; Pierce, A; ter Haar, E; Lauffer, D; Madden, J; Tanner, K; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313051&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 22353185 104147412 CHEMBL1076721 ZINC49525584 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50909019 COc1ccc(cc1OC)C(=O)NCc1cccc(c1)C(=O)Nc1ccc2CCNCc2c1 InChI=1S/C26H27N3O4/c1-32-23-9-7-20(14-24(23)33-2)25(30)28-15-17-4-3-5-19(12-17)26(31)29-22-8-6-18-10-11-27-16-21(18)13-22/h3-9,12-14,27H,10-11,15-16H2,1-2H3,(H,28,30)(H,29,31) AOTJVGQNGQYEAY-UHFFFAOYSA-N 50308876 3,4-Dimethoxy-N-[3-(1,2,3,4-tetrahydro-isoquinolin-7-ylcarbamoyl)-benzyl]-benzamide::CHEMBL604087 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm9014263 10.7270/Q2V125RD 20000469 Morwick, T; Buttner, FH; Cywin, CL; Dahmann, G; Hickey, E; Jakes, S; Kaplita, P; Kashem, MA; Kerr, S; Kugler, S; Mao, W; Marshall, D; Paw, Z; Shih, CK; Wu, F; Young, E Boehringer Ingelheim Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308876&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25057409 104163237 CHEMBL604087 ZINC45390920 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50910196 COc1ccncc1-c1[nH][nH]c(=O)c1N=Nc1ccccc1 InChI=1S/C15H13N5O2/c1-22-12-7-8-16-9-11(12)13-14(15(21)20-18-13)19-17-10-5-3-2-4-6-10/h2-9H,1H3,(H2,18,20,21) NPLOHUPMKKUYFK-UHFFFAOYSA-N 50313061 (Z)-3-(4-methoxypyridin-3-yl)-4-(2-phenylhydrazono)-1H-pyrazol-5(4H)-one::CHEMBL1086736 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2010.01.072 10.7270/Q2TX3G9B 20138514 Arnost, M; Pierce, A; ter Haar, E; Lauffer, D; Madden, J; Tanner, K; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313061&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46880951 104147422 CHEMBL1086736 ZINC49049758 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50921817 COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)ccc3C)c2N)cc1 InChI=1S/C27H24ClF3N6O3/c1-15-3-6-17(34-26(39)35-18-7-10-22(28)21(12-18)27(29,30)31)11-20(15)25(38)36-23-13-33-37(24(23)32)14-16-4-8-19(40-2)9-5-16/h3-13H,14,32H2,1-2H3,(H,36,38)(H2,34,35,39) ZJDFSKSBQBPOSK-UHFFFAOYSA-N 50338873 CHEMBL1684800::N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-2-methylbenzamide Serine/threonine-protein kinase PLK1 Homo sapiens 167.4 ChEMBL 10.1016/j.bmc.2011.01.067 10.7270/Q2D79CD3 21353571 Kim, MH; Kim, M; Yu, H; Kim, H; Yoo, KH; Sim, T; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338873&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 52938983 125088975 CHEMBL1684800 ZINC66147781 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50933451 COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(on4)C(C)(C)C(F)(F)F)c3)c2cc1OC InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33) DKNUPRMJNUQNHR-UHFFFAOYSA-N 50382959 CEP-32496::CHEMBL2029988::US9730937, Example 261 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm2009925 10.7270/Q2571D2T 22168626 Rowbottom, MW; Faraoni, R; Chao, Q; Campbell, BT; Lai, AG; Setti, E; Ezawa, M; Sprankle, KG; Abraham, S; Tran, L; Struss, B; Gibney, M; Armstrong, RC; Gunawardane, RN; Nepomuceno, RR; Valenta, I; Hua, H; Gardner, MF; Cramer, MD; Gitnick, D; Insko, DE; Apuy, JL; Jones-Bolin, S; Ghose, AK; Herbertz, T; Ator, MA; Dorsey, BD; Ruggeri, B; Williams, M; Bhagwat, S; James, J; Holladay, MW Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382959&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 56846693 160862042 CHEMBL2029988 ZINC43207440 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941273 C[C@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)\C=C/C(F)(F)F InChI=1S/C24H25F3N4O2S/c1-14(6-7-24(25,26)27)33-20-10-16(4-5-18(20)23(29)32)19-9-17(11-30-22(19)28)21-8-15(13-34-21)12-31(2)3/h4-11,13-14H,12H2,1-3H3,(H2,28,30)(H2,29,32)/b7-6-/t14-/m0/s1 LLEOOSLUHRQCHZ-AFNCTOJWSA-N 50385914 CHEMBL2042042 Serine/threonine-protein kinase PLK1 Homo sapiens 8410 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57387301 160864997 CHEMBL2042042 ZINC84711742 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941275 C[C@@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)\C=C/C(F)(F)F InChI=1S/C24H25F3N4O2S/c1-14(6-7-24(25,26)27)33-20-10-16(4-5-18(20)23(29)32)19-9-17(11-30-22(19)28)21-8-15(13-34-21)12-31(2)3/h4-11,13-14H,12H2,1-3H3,(H2,28,30)(H2,29,32)/b7-6-/t14-/m1/s1 LLEOOSLUHRQCHZ-LMVHVUTASA-N 50385915 CHEMBL2042135 Serine/threonine-protein kinase PLK1 Homo sapiens 5820 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search GGY 4AFE 56947170 160864998 CHEMBL2042135 ZINC84655247 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941287 C[C@@H](Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cc(CN(C)C)cs1)c1ccccc1C(F)(F)F InChI=1S/C28H27F3N4O2S/c1-16(20-6-4-5-7-23(20)28(29,30)31)37-24-12-18(8-9-21(24)27(33)36)22-11-19(13-34-26(22)32)25-10-17(15-38-25)14-35(2)3/h4-13,15-16H,14H2,1-3H3,(H2,32,34)(H2,33,36)/t16-/m1/s1 DNZGEPPZYMAFLN-MRXNPFEDSA-N 50385916 CHEMBL2042136 Serine/threonine-protein kinase PLK1 Homo sapiens 820 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385916&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search JUP 4A4X 56947168 160864999 CHEMBL2042136 ZINC84655195 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941292 CC(Oc1cc(ccc1C(N)=O)-c1nc(cnc1N)-c1ccc(CN(C)C)cc1)c1ccccc1C(F)(F)F InChI=1S/C29H28F3N5O2/c1-17(21-6-4-5-7-23(21)29(30,31)32)39-25-14-20(12-13-22(25)28(34)38)26-27(33)35-15-24(36-26)19-10-8-18(9-11-19)16-37(2)3/h4-15,17H,16H2,1-3H3,(H2,33,35)(H2,34,38) GWVVKACJTNKJAO-UHFFFAOYSA-N 50385917 CHEMBL2042029 Serine/threonine-protein kinase PLK1 Homo sapiens 3900 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385917&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57386289 160865000 CHEMBL2042029 ZINC84712425 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941293 CC(Oc1cc(ccc1C(N)=O)-c1nc(cnc1N)-c1cccc(CN(C)C)c1)c1ccccc1C(F)(F)F InChI=1S/C29H28F3N5O2/c1-17(21-9-4-5-10-23(21)29(30,31)32)39-25-14-20(11-12-22(25)28(34)38)26-27(33)35-15-24(36-26)19-8-6-7-18(13-19)16-37(2)3/h4-15,17H,16H2,1-3H3,(H2,33,35)(H2,34,38) QJRLRIHVMQQFHO-UHFFFAOYSA-N 50385918 CHEMBL2042030 Serine/threonine-protein kinase PLK1 Homo sapiens 12100 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385918&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57386290 160865001 CHEMBL2042030 ZINC84712429 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941294 CC(Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1ccc(CN(C)C)cc1)c1ccccc1C(F)(F)F InChI=1S/C30H29F3N4O2/c1-18(23-6-4-5-7-26(23)30(31,32)33)39-27-15-21(12-13-24(27)29(35)38)25-14-22(16-36-28(25)34)20-10-8-19(9-11-20)17-37(2)3/h4-16,18H,17H2,1-3H3,(H2,34,36)(H2,35,38) KPYFHKXGOZSVEX-UHFFFAOYSA-N 50385919 CHEMBL2042031 Serine/threonine-protein kinase PLK1 Homo sapiens 1560 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57386803 160865002 CHEMBL2042031 ZINC84654622 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941295 CC(Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1cccc(CN(C)C)c1)c1ccccc1C(F)(F)F InChI=1S/C30H29F3N4O2/c1-18(23-9-4-5-10-26(23)30(31,32)33)39-27-15-21(11-12-24(27)29(35)38)25-14-22(16-36-28(25)34)20-8-6-7-19(13-20)17-37(2)3/h4-16,18H,17H2,1-3H3,(H2,34,36)(H2,35,38) SJDSHZKOFYRALI-UHFFFAOYSA-N 50385913 CHEMBL2042032 Serine/threonine-protein kinase PLK1 Homo sapiens 3290 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385913&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57386804 160864996 CHEMBL2042032 ZINC84654627 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50941296 CC(Oc1cc(ccc1C(N)=O)-c1cc(cnc1N)-c1ccc(CN(C)C)s1)c1ccccc1C(F)(F)F InChI=1S/C28H27F3N4O2S/c1-16(20-6-4-5-7-23(20)28(29,30)31)37-24-13-17(8-10-21(24)27(33)36)22-12-18(14-34-26(22)32)25-11-9-19(38-25)15-35(2)3/h4-14,16H,15H2,1-3H3,(H2,32,34)(H2,33,36) AKWNDIGQZONPHP-UHFFFAOYSA-N 50385922 CHEMBL2042035 Serine/threonine-protein kinase PLK1 Homo sapiens 500 ChEMBL 10.1021/jm201683b 10.7270/Q2Q81F4F 22404346 Innocenti, P; Cheung, KM; Solanki, S; Mas-Droux, C; Rowan, F; Yeoh, S; Boxall, K; Westlake, M; Pickard, L; Hardy, T; Baxter, JE; Aherne, GW; Bayliss, R; Fry, AM; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385922&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57386805 160865005 CHEMBL2042035 ZINC84655416 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50943011 CC(C)(N)C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc5sncc45)c(Cl)c3)c12 InChI=1S/C25H24ClN7O2S/c1-25(2,27)24(34)28-9-11-33-10-8-18-22(33)23(30-14-29-18)32-15-6-7-20(17(26)12-15)35-19-4-3-5-21-16(19)13-31-36-21/h3-8,10,12-14H,9,11,27H2,1-2H3,(H,28,34)(H,29,30,32) AVHNHPHSQMBYAJ-UHFFFAOYSA-N 50386693 CHEMBL2048912 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm300185p 10.7270/Q2474BX1 22439974 Kawakita, Y; Banno, H; Ohashi, T; Tamura, T; Yusa, T; Nakayama, A; Miki, H; Iwata, H; Kamiguchi, H; Tanaka, T; Habuka, N; Sogabe, S; Ohta, Y; Ishikawa, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386693&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44229839 160865776 CHEMBL2048912 ZINC43208438 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50943190 Cc1ccc(NC(=O)Nc2nnc(Sc3ncnc4cc(OCCCN5CCOCC5)ccc34)s2)cc1 InChI=1S/C25H27N7O3S2/c1-17-3-5-18(6-4-17)28-23(33)29-24-30-31-25(37-24)36-22-20-8-7-19(15-21(20)26-16-27-22)35-12-2-9-32-10-13-34-14-11-32/h3-8,15-16H,2,9-14H2,1H3,(H2,28,29,30,33) LKXFSTAQMOENSC-UHFFFAOYSA-N 50386749 CHEMBL2046883 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm300042x 10.7270/Q2M61M94 22452518 Li, WW; Wang, XY; Zheng, RL; Yan, HX; Cao, ZX; Zhong, L; Wang, ZR; Ji, P; Yang, LL; Wang, LJ; Xu, Y; Liu, JJ; Yang, J; Zhang, CH; Ma, S; Feng, S; Sun, QZ; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386749&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57412684 160865832 CHEMBL2046883 ZINC84757130 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938783 Cn1c(nc2ccccc12)-c1ccnc(Nc2ccccc2)n1 InChI=1S/C18H15N5/c1-23-16-10-6-5-9-14(16)21-17(23)15-11-12-19-18(22-15)20-13-7-3-2-4-8-13/h2-12H,1H3,(H,19,20,22) XZWBCWGUXRTCRD-UHFFFAOYSA-N 50385171 CHEMBL2036725 Serine/threonine-protein kinase PLK1 Homo sapiens 60000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385171&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60165993 160864254 CHEMBL2036725 ZINC84726030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938788 Cc1ccc(Nc2nccc(n2)-c2nc3ccccc3n2C)cc1 InChI=1S/C19H17N5/c1-13-7-9-14(10-8-13)21-19-20-12-11-16(23-19)18-22-15-5-3-4-6-17(15)24(18)2/h3-12H,1-2H3,(H,20,21,23) AYDBKOFFSNZNIW-UHFFFAOYSA-N 50385172 CHEMBL2036726 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385172&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60165994 160864255 CHEMBL2036726 ZINC84726033 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938792 Cn1c(nc2ccccc12)-c1ccnc(Nc2ccc(Cl)cc2)n1 InChI=1S/C18H14ClN5/c1-24-16-5-3-2-4-14(16)22-17(24)15-10-11-20-18(23-15)21-13-8-6-12(19)7-9-13/h2-11H,1H3,(H,20,21,23) MLYOBUVJVMVCCI-UHFFFAOYSA-N 50385173 CHEMBL2036727 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385173&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60165995 160864256 CHEMBL2036727 ZINC84726036 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938794 COc1ccc(Nc2nccc(n2)-c2nc3ccccc3n2C)cc1O InChI=1S/C19H17N5O2/c1-24-15-6-4-3-5-13(15)22-18(24)14-9-10-20-19(23-14)21-12-7-8-17(26-2)16(25)11-12/h3-11,25H,1-2H3,(H,20,21,23) YVQWJUWRPUTYMY-UHFFFAOYSA-N 50385175 CHEMBL2036866 Serine/threonine-protein kinase PLK1 Homo sapiens 1200 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385175&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60166141 160864258 CHEMBL2036866 ZINC84711113 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938796 Cn1c(nc2ccccc12)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C22H22N6O/c1-27-20-5-3-2-4-18(20)25-21(27)19-10-11-23-22(26-19)24-16-6-8-17(9-7-16)28-12-14-29-15-13-28/h2-11H,12-15H2,1H3,(H,23,24,26) JHACYRDRFCKQIN-UHFFFAOYSA-N 50385170 CHEMBL2036728 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385170&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60166135 160864253 CHEMBL2036728 ZINC84709511 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938801 CCOc1ccc(Nc2nccc(n2)-c2nc3ccccc3n2C)cc1 InChI=1S/C20H19N5O/c1-3-26-15-10-8-14(9-11-15)22-20-21-13-12-17(24-20)19-23-16-6-4-5-7-18(16)25(19)2/h4-13H,3H2,1-2H3,(H,21,22,24) INVYTVJSPDWQAX-UHFFFAOYSA-N 50385176 CHEMBL2036867 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385176&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60166136 160864259 CHEMBL2036867 ZINC84652352 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938806 COc1ccc(Nc2nccc(n2)-c2nc3ccccc3n2C)cc1 InChI=1S/C19H17N5O/c1-24-17-6-4-3-5-15(17)22-18(24)16-11-12-20-19(23-16)21-13-7-9-14(25-2)10-8-13/h3-12H,1-2H3,(H,20,21,23) QYUAAGZZXLCOSX-UHFFFAOYSA-N 50385177 CHEMBL2036868 Serine/threonine-protein kinase PLK1 Homo sapiens 15000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385177&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60166137 160864260 CHEMBL2036868 ZINC84708005 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938810 Cn1c(nc2ccccc12)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C18H15N5O/c1-23-16-5-3-2-4-14(16)21-17(23)15-10-11-19-18(22-15)20-12-6-8-13(24)9-7-12/h2-11,24H,1H3,(H,19,20,22) AIOUPIKZGJLTGH-UHFFFAOYSA-N 50385174 CHEMBL2036869 Serine/threonine-protein kinase PLK1 Homo sapiens 12000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385174&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60166138 160864257 CHEMBL2036869 ZINC84708008 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938815 Cn1c(nc2ccccc12)-c1ccnc(Nc2cccc(O)c2)n1 InChI=1S/C18H15N5O/c1-23-16-8-3-2-7-14(16)21-17(23)15-9-10-19-18(22-15)20-12-5-4-6-13(24)11-12/h2-11,24H,1H3,(H,19,20,22) UCVQLBSVUSGATC-UHFFFAOYSA-N 50385178 CHEMBL2036870 Serine/threonine-protein kinase PLK1 Homo sapiens 3700 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385178&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60166139 160864261 CHEMBL2036870 ZINC84708012 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938820 Cn1c(nc2ccccc12)-c1ccnc(Nc2ccc(O)c(Cl)c2)n1 InChI=1S/C18H14ClN5O/c1-24-15-5-3-2-4-13(15)22-17(24)14-8-9-20-18(23-14)21-11-6-7-16(25)12(19)10-11/h2-10,25H,1H3,(H,20,21,23) MQKRJXAMWDNEQQ-UHFFFAOYSA-N 50385179 CHEMBL2036865 Serine/threonine-protein kinase PLK1 Homo sapiens 6000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385179&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60166140 160864262 CHEMBL2036865 ZINC84710310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938829 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938834 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938840 Cn1c(nc2ccccc12)-c1ccc2c(n1)n(C)c(=O)n(C)c2=O InChI=1S/C17H15N5O2/c1-20-13-7-5-4-6-11(13)18-15(20)12-9-8-10-14(19-12)21(2)17(24)22(3)16(10)23/h4-9H,1-3H3 JQGGHSNULNGIAQ-UHFFFAOYSA-N 50385180 CHEMBL2036871 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385180&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60165992 160864263 CHEMBL2036871 ZINC84708015 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50938844 COc1ccc(Nc2ncc3CC(=O)Nc4ccccc4-c3n2)cc1O InChI=1S/C19H16N4O3/c1-26-16-7-6-12(9-15(16)24)21-19-20-10-11-8-17(25)22-14-5-3-2-4-13(14)18(11)23-19/h2-7,9-10,24H,8H2,1H3,(H,22,25)(H,20,21,23) SRLAWDYDLHMAMZ-UHFFFAOYSA-N 50308188 2-(3-Hydroxy-4-methoxyanilino)-5,7-dihydro-6H-pyrimido[5,4-d]-[1]benzazepin-6-one::CHEMBL603463 Serine/threonine-protein kinase PLK1 Homo sapiens 5700 ChEMBL 10.1016/j.ejmech.2012.04.007 10.7270/Q2W66MT7 22560627 Determann, R; Dreher, J; Baumann, K; Preu, L; Jones, PG; Totzke, F; Schachtele, C; Kubbutat, MH; Kunick, C Technische Universit£t Braunschweig http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308188&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16730105 104162549 CHEMBL603463 ZINC45389131 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50943388 Cc1cc(ccc1Nc1nc(NC2CCCCC2)c2[nH]cnc2n1)N1CCOCC1 InChI=1S/C22H29N7O/c1-15-13-17(29-9-11-30-12-10-29)7-8-18(15)26-22-27-20-19(23-14-24-20)21(28-22)25-16-5-3-2-4-6-16/h7-8,13-14,16H,2-6,9-12H2,1H3,(H3,23,24,25,26,27,28) OVJBNYKNHXJGSA-UHFFFAOYSA-N 50386816 CHEMBL2047943 Serine/threonine-protein kinase PLK1 Homo sapiens >5000 ChEMBL 10.1016/j.bmcl.2012.04.131 10.7270/Q2PZ59V9 22632936 Vijay Kumar, D; Hoarau, C; Bursavich, M; Slattum, P; Gerrish, D; Yager, K; Saunders, M; Shenderovich, M; Roth, BL; McKinnon, R; Chan, A; Cimbora, DM; Bradford, C; Reeves, L; Patton, S; Papac, DI; Williams, BL; Carlson, RO Myrexis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386816&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 8PT 5N7V 46909588 160865899 CHEMBL2047943 ZINC68246140 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50943389 C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2nc[nH]c12 InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27) ZFLJHSQHILSNCM-UHFFFAOYSA-N 50170831 CHEMBL188343::N*6*-Cyclohexyl-N*2*-(4-morpholin-4-yl-phenyl)-9H-purine-2,6-diamine::N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine::N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine Serine/threonine-protein kinase PLK1 Homo sapiens >5000 ChEMBL 10.1016/j.bmcl.2012.04.131 10.7270/Q2PZ59V9 22632936 Vijay Kumar, D; Hoarau, C; Bursavich, M; Slattum, P; Gerrish, D; Yager, K; Saunders, M; Shenderovich, M; Roth, BL; McKinnon, R; Chan, A; Cimbora, DM; Bradford, C; Reeves, L; Patton, S; Papac, DI; Williams, BL; Carlson, RO Myrexis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50170831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50170831&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 210332 104057211 70723 CHEMBL188343 ZINC03620786 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50944564 CC(C)C[C@H]1CN(CCN1)c1ccc(c(n1)C(=O)c1cccnc1N)C(F)(F)F InChI=1S/C20H24F3N5O/c1-12(2)10-13-11-28(9-8-25-13)16-6-5-15(20(21,22)23)17(27-16)18(29)14-4-3-7-26-19(14)24/h3-7,12-13,25H,8-11H2,1-2H3,(H2,24,26)/t13-/m0/s1 XWKJUHBICAMYNW-ZDUSSCGKSA-N 50387330 CHEMBL2046643 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2012.05.114 10.7270/Q2TM7C65 22738630 Jimenez, JM; Davis, C; Boyall, D; Fraysse, D; Knegtel, R; Settimo, L; Young, S; Bolton, C; Chiu, P; Curnock, A; Rasmussen, R; Tanner, A; Ager, I Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387330&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24995659 160866413 CHEMBL2046643 ZINC84758312 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50954396 CC(C)(C(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(Cl)c4)c(Cl)c3)c12)S(C)(=O)=O InChI=1S/C25H25Cl2N5O4S/c1-25(2,37(3,34)35)24(33)28-10-12-32-11-9-20-22(32)23(30-15-29-20)31-17-7-8-21(19(27)14-17)36-18-6-4-5-16(26)13-18/h4-9,11,13-15H,10,12H2,1-3H3,(H,28,33)(H,29,30,31) UVBKNBPCVRBUTF-UHFFFAOYSA-N 50391643 CHEMBL2148052::CHEMBL2148053 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2012.08.002 10.7270/Q21R6RMZ 22980219 Kawakita, Y; Miwa, K; Seto, M; Banno, H; Ohta, Y; Tamura, T; Yusa, T; Miki, H; Kamiguchi, H; Ikeda, Y; Tanaka, T; Kamiyama, K; Ishikawa, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391643&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57496699 163340667 CHEMBL2148052CHEMBL2148053 ZINC43153603 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51088150 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Serine/threonine-protein kinase PLK1 Homo sapiens 5750 ChEMBL 10.1021/np4005745 10.7270/Q2X63PDV 24328302 El Amrani, M; Lai, D; Debbab, A; Aly, AH; Siems, K; Seidel, C; Schnekenburger, M; Gaigneaux, A; Diederich, M; Feger, D; Lin, W; Proksch, P Heinrich-Heine-Universit£t D£sseldorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search QUE 3BPT,2HCK,3LJ0,4LMU,5FLI,5FLJ,3CF8,4DFU,4MRA,4WNJ,2O3P,2MS6,5AUW,3BXX,6M89,3LM5,1GP6,6AWS,6QCN,6QCD,7VUM,6B1D,2N6C,1E8W,2C9Z,5XG4,5A4V,2UXH,1H1I,2JJ2,6TTA,6IJD,3NVY 5280343 11108251 16243 CHEMBL50 DB04216 5346 C00389 ZINC03869685 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51088151 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 540 ChEMBL 10.1021/np4005745 10.7270/Q2X63PDV 24328302 El Amrani, M; Lai, D; Debbab, A; Aly, AH; Siems, K; Seidel, C; Schnekenburger, M; Gaigneaux, A; Diederich, M; Feger, D; Lin, W; Proksch, P Heinrich-Heine-Universit£t D£sseldorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51088152 Cc1c(O)c(O)c2oc(cc2c1C=O)-c1c(C)c(O)c(O)c(O)c1C=O InChI=1S/C18H14O8/c1-6-9(4-19)8-3-11(26-18(8)17(25)13(6)21)12-7(2)14(22)16(24)15(23)10(12)5-20/h3-5,21-25H,1-2H3 HTCVSLIHSFBUEL-UHFFFAOYSA-N 50445474 CHEMBL3104855 Serine/threonine-protein kinase PLK1 Homo sapiens 6310 ChEMBL 10.1021/np4005745 10.7270/Q2X63PDV 24328302 El Amrani, M; Lai, D; Debbab, A; Aly, AH; Siems, K; Seidel, C; Schnekenburger, M; Gaigneaux, A; Diederich, M; Feger, D; Lin, W; Proksch, P Heinrich-Heine-Universit£t D£sseldorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445474&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11210533 194943370 CHEMBL3104855 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51088153 Cc1c2COC(=O)c2c(O)c(O)c1O InChI=1S/C9H8O5/c1-3-4-2-14-9(13)5(4)7(11)8(12)6(3)10/h10-12H,2H2,1H3 IREYRQPUBOQACQ-UHFFFAOYSA-N 50445475 CHEMBL3104854 Serine/threonine-protein kinase PLK1 Homo sapiens 11800 ChEMBL 10.1021/np4005745 10.7270/Q2X63PDV 24328302 El Amrani, M; Lai, D; Debbab, A; Aly, AH; Siems, K; Seidel, C; Schnekenburger, M; Gaigneaux, A; Diederich, M; Feger, D; Lin, W; Proksch, P Heinrich-Heine-Universit£t D£sseldorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445475&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 76328313 194943371 CHEMBL3104854 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51088154 COCc1c(C)c(O)c(O)c(O)c1C=O InChI=1S/C10H12O5/c1-5-7(4-15-2)6(3-11)9(13)10(14)8(5)12/h3,12-14H,4H2,1-2H3 WTFXMLVITCJWNE-UHFFFAOYSA-N 50445471 CHEMBL3104853 Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1021/np4005745 10.7270/Q2X63PDV 24328302 El Amrani, M; Lai, D; Debbab, A; Aly, AH; Siems, K; Seidel, C; Schnekenburger, M; Gaigneaux, A; Diederich, M; Feger, D; Lin, W; Proksch, P Heinrich-Heine-Universit£t D£sseldorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445471&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 76324771 194943367 CHEMBL3104853 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51088155 COC1OC(=O)c2c1c(C)c(O)c(O)c2O InChI=1S/C10H10O6/c1-3-4-5(7(12)8(13)6(3)11)9(14)16-10(4)15-2/h10-13H,1-2H3 PZBSSTRXBNWBNX-UHFFFAOYSA-N 50445472 CHEMBL3104852 Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1021/np4005745 10.7270/Q2X63PDV 24328302 El Amrani, M; Lai, D; Debbab, A; Aly, AH; Siems, K; Seidel, C; Schnekenburger, M; Gaigneaux, A; Diederich, M; Feger, D; Lin, W; Proksch, P Heinrich-Heine-Universit£t D£sseldorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445472&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 76310169 194943368 CHEMBL3104852 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51088156 Cc1c(O)c(O)c2O[C@H]3O[C@H](C(=O)c4c(O)c(O)c(O)c(C)c34)c2c1C=O InChI=1S/C18H14O9/c1-4-6(3-19)8-16-13(23)9-7(5(2)11(21)14(24)12(9)22)18(26-16)27-17(8)15(25)10(4)20/h3,16,18,20-22,24-25H,1-2H3/t16-,18+/m0/s1 AHNFXMBOWJVAPB-FUHWJXTLSA-N 50445473 CHEMBL3104851 Serine/threonine-protein kinase PLK1 Homo sapiens 3180 ChEMBL 10.1021/np4005745 10.7270/Q2X63PDV 24328302 El Amrani, M; Lai, D; Debbab, A; Aly, AH; Siems, K; Seidel, C; Schnekenburger, M; Gaigneaux, A; Diederich, M; Feger, D; Lin, W; Proksch, P Heinrich-Heine-Universit£t D£sseldorf http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445473&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 73891099 194943369 CHEMBL3104851 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51090304 COC(=O)c1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1 InChI=1S/C23H32O4/c1-14-7-6-8-19-22(14,3)10-9-15(2)23(19,4)13-17-11-16(21(26)27-5)12-18(24)20(17)25/h7,11-12,15,19,24-25H,6,8-10,13H2,1-5H3/t15-,19+,22-,23+/m0/s1 VXQUGYOYJDITTO-KNSMUJDWSA-N 50446564 CHEMBL3109404 Serine/threonine-protein kinase PLK1 Homo sapiens 21700 ChEMBL 10.1021/np400633m 10.7270/Q24F1S7C 24479418 Daletos, G; de Voogd, NJ; Muller, WE; Wray, V; Lin, W; Feger, D; Kubbutat, M; Aly, AH; Proksch, P Heinrich Heine Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446564&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10714343 194944460 CHEMBL3109404 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51090305 COc1cc2nc(C)oc2c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O InChI=1S/C24H33NO3/c1-14-8-7-9-20-23(14,4)11-10-15(2)24(20,5)13-17-21(26)19(27-6)12-18-22(17)28-16(3)25-18/h8,12,15,20,26H,7,9-11,13H2,1-6H3/t15-,20+,23-,24+/m0/s1 ATQVAIUSAHRLDF-KSVBPBMVSA-N 50446565 CHEMBL3109402 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/np400633m 10.7270/Q24F1S7C 24479418 Daletos, G; de Voogd, NJ; Muller, WE; Wray, V; Lin, W; Feger, D; Kubbutat, M; Aly, AH; Proksch, P Heinrich Heine Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446565&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 76335685 194944461 CHEMBL3109402 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51090306 CC(C)CC=Nc1cc(O)c(O)c(C[C@]2(C)[C@@H](C)CC[C@]3(C)[C@H]2CCC=C3C)c1O InChI=1S/C26H39NO3/c1-16(2)11-13-27-20-14-21(28)24(30)19(23(20)29)15-26(6)18(4)10-12-25(5)17(3)8-7-9-22(25)26/h8,13-14,16,18,22,28-30H,7,9-12,15H2,1-6H3/t18-,22+,25-,26+/m0/s1 RBPGWOOSHFMNKR-NZZVAQPWSA-N 50446566 CHEMBL3109401 Serine/threonine-protein kinase PLK1 Homo sapiens 100000 ChEMBL 10.1021/np400633m 10.7270/Q24F1S7C 24479418 Daletos, G; de Voogd, NJ; Muller, WE; Wray, V; Lin, W; Feger, D; Kubbutat, M; Aly, AH; Proksch, P Heinrich Heine Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446566&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91898676 194944462 CHEMBL3109401 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51082268 CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(CC2)C2CCC3(CC2)OCCO3)cc1 InChI=1S/C31H38N4O7/c1-34(2)21-3-5-24(6-4-21)41-27-18-23(36)17-26(37)29(27)28-19-25(33-42-28)30(38)32-20-9-13-35(14-10-20)22-7-11-31(12-8-22)39-15-16-40-31/h3-6,17-20,22,36-37H,7-16H2,1-2H3,(H,32,38) DPZWKZQIGWCTDT-UHFFFAOYSA-N 50442757 CHEMBL2443026 Serine/threonine-protein kinase PLK1 Homo sapiens >10.0 ChEMBL 10.1016/j.bmc.2013.09.018 10.7270/Q2V989HZ 24100158 Brasca, MG; Mantegani, S; Amboldi, N; Bindi, S; Caronni, D; Casale, E; Ceccarelli, W; Colombo, N; De Ponti, A; Donati, D; Ermoli, A; Fachin, G; Felder, ER; Ferguson, RD; Fiorelli, C; Guanci, M; Isacchi, A; Pesenti, E; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Fogliatto, G Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442757&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 72696079 175455074 CHEMBL2443026 ZINC68247155 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51082269 CC(C)Nc1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1 InChI=1S/C25H30N4O5/c1-15(2)26-16-4-6-19(7-5-16)33-22-13-18(30)12-21(31)24(22)23-14-20(28-34-23)25(32)27-17-8-10-29(3)11-9-17/h4-7,12-15,17,26,30-31H,8-11H2,1-3H3,(H,27,32) PFINYWQVHGQFKS-UHFFFAOYSA-N 50442758 CHEMBL2443139 Serine/threonine-protein kinase PLK1 Homo sapiens >10.0 ChEMBL 10.1016/j.bmc.2013.09.018 10.7270/Q2V989HZ 24100158 Brasca, MG; Mantegani, S; Amboldi, N; Bindi, S; Caronni, D; Casale, E; Ceccarelli, W; Colombo, N; De Ponti, A; Donati, D; Ermoli, A; Fachin, G; Felder, ER; Ferguson, RD; Fiorelli, C; Guanci, M; Isacchi, A; Pesenti, E; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Fogliatto, G Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442758&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 73346589 175455075 CHEMBL2443139 ZINC96286428 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51082270 CN(C)c1ccc(Oc2cc(O)cc(O)c2-c2cc(no2)C(=O)NC2CCN(C)CC2)cc1 InChI=1S/C24H28N4O5/c1-27(2)16-4-6-18(7-5-16)32-21-13-17(29)12-20(30)23(21)22-14-19(26-33-22)24(31)25-15-8-10-28(3)11-9-15/h4-7,12-15,29-30H,8-11H2,1-3H3,(H,25,31) VUOFPKJWKCCHBI-UHFFFAOYSA-N 50442759 CHEMBL2443138 Serine/threonine-protein kinase PLK1 Homo sapiens >10.0 ChEMBL 10.1016/j.bmc.2013.09.018 10.7270/Q2V989HZ 24100158 Brasca, MG; Mantegani, S; Amboldi, N; Bindi, S; Caronni, D; Casale, E; Ceccarelli, W; Colombo, N; De Ponti, A; Donati, D; Ermoli, A; Fachin, G; Felder, ER; Ferguson, RD; Fiorelli, C; Guanci, M; Isacchi, A; Pesenti, E; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Fogliatto, G Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442759&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49782469 175455076 CHEMBL2443138 ZINC68247151 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51082271 CN1CCC(CC1)NC(=O)c1cc(on1)-c1c(O)cc(O)cc1Oc1ccc(cc1)[N+]([O-])=O InChI=1S/C22H22N4O7/c1-25-8-6-13(7-9-25)23-22(29)17-12-20(33-24-17)21-18(28)10-15(27)11-19(21)32-16-4-2-14(3-5-16)26(30)31/h2-5,10-13,27-28H,6-9H2,1H3,(H,23,29) YLQODGGPIHWTHR-UHFFFAOYSA-N 50442760 CHEMBL2443044 Serine/threonine-protein kinase PLK1 Homo sapiens >10.0 ChEMBL 10.1016/j.bmc.2013.09.018 10.7270/Q2V989HZ 24100158 Brasca, MG; Mantegani, S; Amboldi, N; Bindi, S; Caronni, D; Casale, E; Ceccarelli, W; Colombo, N; De Ponti, A; Donati, D; Ermoli, A; Fachin, G; Felder, ER; Ferguson, RD; Fiorelli, C; Guanci, M; Isacchi, A; Pesenti, E; Polucci, P; Riceputi, L; Sola, F; Visco, C; Zuccotto, F; Fogliatto, G Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442760&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9UN 4B7P 49782688 175455077 CHEMBL2443044 ZINC95921417 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51090036 CN(C)C(=O)c1ccc(Nc2cc3n(C(=O)OC(C)(C)C)c(cc3cn2)-c2cnn(C)c2)c(Cl)c1 InChI=1S/C25H27ClN6O3/c1-25(2,3)35-24(34)32-20(17-13-28-31(6)14-17)10-16-12-27-22(11-21(16)32)29-19-8-7-15(9-18(19)26)23(33)30(4)5/h7-14H,1-6H3,(H,27,29) KYBALIQJYSWGLI-UHFFFAOYSA-N 50446431 CHEMBL3109933 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1021/jm401395s 10.7270/Q2JM2C4W 24256217 Naud, S; Westwood, IM; Faisal, A; Sheldrake, P; Bavetsias, V; Atrash, B; Cheung, KM; Liu, M; Hayes, A; Schmitt, J; Wood, A; Choi, V; Boxall, K; Mak, G; Gurden, M; Valenti, M; de Haven Brandon, A; Henley, A; Baker, R; McAndrew, C; Matijssen, B; Burke, R; Hoelder, S; Eccles, SA; Raynaud, FI; Linardopoulos, S; van Montfort, RL; Blagg, J The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446431&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7RO 4C4H,4C4G,5AP5 68310278 194944327 CHEMBL3109933 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982991 COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 QDLHCMPXEPAAMD-QAIWCSMKSA-N 15234 (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate::CHEMBL428496::NSC221019::Wortmannin::Wortmannin, Wm::cid_312145 Serine/threonine-protein kinase PLK1 Homo sapiens 24 ChEMBL 10.1021/jm3003203 10.7270/Q2X92CGP 22621397 Barf, T; Kaptein, A Covalution Pharma BV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15234&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search KWT 3HHM,1E7U,7OTV,3D5X 312145 46515542 52289 CHEMBL428496 DB08059 6060 C15181 ZINC01619592 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980722 CC(Nc1c(Nc2ccncc2)c(=O)c1=O)C(C)(C)C InChI=1S/C15H19N3O2/c1-9(15(2,3)4)17-11-12(14(20)13(11)19)18-10-5-7-16-8-6-10/h5-9,17H,1-4H3,(H,16,18) IQNOGQGSOHNMCL-UHFFFAOYSA-N 50402022 CHEMBL549730 Serine/threonine-protein kinase PLK1 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402022&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9881974 163351046 CHEMBL549730 ZINC49627076 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980725 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 0.870000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980726 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980739 C[C@@H](Nc1c(Nc2ccnc(Nc3cccnc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C19H22N6O2/c1-11(19(2,3)4)22-14-15(17(27)16(14)26)24-13-7-9-21-18(25-13)23-12-6-5-8-20-10-12/h5-11,22H,1-4H3,(H2,21,23,24,25)/t11-/m1/s1 JYFUPVGUBMFMLF-LLVKDONJSA-N 50402024 CHEMBL2205439 Serine/threonine-protein kinase PLK1 Homo sapiens >44000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402024&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71452345 163351048 CHEMBL2205439 ZINC95558392 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980740 C[C@@H](Nc1c(Nc2ccnc(Nc3ccncc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C19H22N6O2/c1-11(19(2,3)4)22-14-15(17(27)16(14)26)24-13-7-10-21-18(25-13)23-12-5-8-20-9-6-12/h5-11,22H,1-4H3,(H2,20,21,23,24,25)/t11-/m1/s1 GZKFPWYJXLPJBT-LLVKDONJSA-N 50402025 CHEMBL2205438 Serine/threonine-protein kinase PLK1 Homo sapiens >44000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402025&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71452344 163351049 CHEMBL2205438 ZINC95562197 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980743 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc-4c(Cc5ccccc-45)c3)n2)c(=O)c1=O InChI=1S/C25H23N5O2/c1-25(2,3)30-21-20(22(31)23(21)32)28-19-10-11-26-24(29-19)27-16-8-9-18-15(13-16)12-14-6-4-5-7-17(14)18/h4-11,13,30H,12H2,1-3H3,(H2,26,27,28,29) DZSCOPNYGJCJSL-UHFFFAOYSA-N 50402021 CHEMBL2205458 Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402021&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461303 163351045 CHEMBL2205458 ZINC95560279 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980744 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O InChI=1S/C24H23N5O2/c1-24(2,3)29-20-19(21(30)22(20)31)27-18-13-14-25-23(28-18)26-17-11-9-16(10-12-17)15-7-5-4-6-8-15/h4-14,29H,1-3H3,(H2,25,26,27,28) NFYCWRMARFWDOP-UHFFFAOYSA-N 50402026 CHEMBL2205457 Serine/threonine-protein kinase PLK1 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402026&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450503 163351050 CHEMBL2205457 ZINC95558196 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980758 CC(C)(C)Nc1c(Nc2nc(Nc3ccc-4c(Cc5ccccc-45)c3)ncc2F)c(=O)c1=O InChI=1S/C25H22FN5O2/c1-25(2,3)31-20-19(21(32)22(20)33)29-23-18(26)12-27-24(30-23)28-15-8-9-17-14(11-15)10-13-6-4-5-7-16(13)17/h4-9,11-12,31H,10H2,1-3H3,(H2,27,28,29,30) VLAKQXHUHYLOOJ-UHFFFAOYSA-N 50402027 CHEMBL2205460 Serine/threonine-protein kinase PLK1 Homo sapiens >8800 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402027&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457666 163351051 CHEMBL2205460 ZINC95562935 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980759 C[C@@H](Nc1c(Nc2cccnc2)c(=O)c1=O)C(C)(C)C InChI=1S/C15H19N3O2/c1-9(15(2,3)4)17-11-12(14(20)13(11)19)18-10-6-5-7-16-8-10/h5-9,17-18H,1-4H3/t9-/m1/s1 PZOAMGLKNVWVPY-SECBINFHSA-N 50402028 CHEMBL2205468 Serine/threonine-protein kinase PLK1 Homo sapiens >44000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402028&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10635986 163351052 CHEMBL2205468 ZINC67854473 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980760 C[C@@H](Nc1c(Nc2ccnc(Nc3ccccn3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C19H22N6O2/c1-11(19(2,3)4)22-14-15(17(27)16(14)26)23-13-8-10-21-18(25-13)24-12-7-5-6-9-20-12/h5-11,22H,1-4H3,(H2,20,21,23,24,25)/t11-/m1/s1 MNIFVAIKMJGHIG-LLVKDONJSA-N 50402029 CHEMBL2205440 Serine/threonine-protein kinase PLK1 Homo sapiens 40800 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402029&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459558 163351053 CHEMBL2205440 ZINC95564209 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980761 CC(Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O)c1ccccc1 InChI=1S/C28H23N5O2/c1-18(19-8-4-2-5-9-19)30-24-25(27(35)26(24)34)32-23-16-17-29-28(33-23)31-22-14-12-21(13-15-22)20-10-6-3-7-11-20/h2-18,30H,1H3,(H2,29,31,32,33) AIKGUTQNYAWOOA-UHFFFAOYSA-N 50402030 CHEMBL2205454 Serine/threonine-protein kinase PLK1 Homo sapiens 24900 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402030&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457665 163351054 CHEMBL2205454 ZINC95562633 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980762 FC(F)(F)Oc1ccc(Nc2c(Nc3ccnc(Nc4ccc(cc4)-c4ccccc4)n3)c(=O)c2=O)cc1 InChI=1S/C27H18F3N5O3/c28-27(29,30)38-20-12-10-18(11-13-20)32-22-23(25(37)24(22)36)34-21-14-15-31-26(35-21)33-19-8-6-17(7-9-19)16-4-2-1-3-5-16/h1-15,32H,(H2,31,33,34,35) SSWUPFAVGNSTID-UHFFFAOYSA-N 50402031 CHEMBL2205453 Serine/threonine-protein kinase PLK1 Homo sapiens 17600 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402031&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450502 163351055 CHEMBL2205453 ZINC95561523 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980763 O=c1c(NCC2CC2)c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c1=O InChI=1S/C24H21N5O2/c30-22-20(26-14-15-6-7-15)21(23(22)31)28-19-12-13-25-24(29-19)27-18-10-8-17(9-11-18)16-4-2-1-3-5-16/h1-5,8-13,15,26H,6-7,14H2,(H2,25,27,28,29) WAXRHCHSJASMPS-UHFFFAOYSA-N 50402032 CHEMBL2205452 Serine/threonine-protein kinase PLK1 Homo sapiens 14000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402032&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450501 163351056 CHEMBL2205452 ZINC95559152 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980764 C[C@@H](Nc1nccc(Nc2c(N[C@H](C)C(C)(C)C)c(=O)c2=O)n1)c1ccccc1 InChI=1S/C22H27N5O2/c1-13(15-9-7-6-8-10-15)24-21-23-12-11-16(27-21)26-18-17(19(28)20(18)29)25-14(2)22(3,4)5/h6-14,25H,1-5H3,(H2,23,24,26,27)/t13-,14-/m1/s1 OFLBXEBHKITSOC-ZIAGYGMSSA-N 50402033 CHEMBL2205441 Serine/threonine-protein kinase PLK1 Homo sapiens 9930 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402033&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24864676 163351057 CHEMBL2205441 ZINC95560165 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980765 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)N3CCOCC3)n2)c(=O)c1=O InChI=1S/C22H26N6O3/c1-22(2,3)27-18-17(19(29)20(18)30)25-16-8-9-23-21(26-16)24-14-4-6-15(7-5-14)28-10-12-31-13-11-28/h4-9,27H,10-13H2,1-3H3,(H2,23,24,25,26) FWSYSJUGLNYDIH-UHFFFAOYSA-N 50402034 CHEMBL2205463 Serine/threonine-protein kinase PLK1 Homo sapiens 8890 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402034&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71452347 163351058 CHEMBL2205463 ZINC95563449 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980766 O=c1c(NCCN2CCOCC2)c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c1=O InChI=1S/C26H26N6O3/c33-24-22(27-12-13-32-14-16-35-17-15-32)23(25(24)34)30-21-10-11-28-26(31-21)29-20-8-6-19(7-9-20)18-4-2-1-3-5-18/h1-11,27H,12-17H2,(H2,28,29,30,31) FIYDTPHDBZNCHZ-UHFFFAOYSA-N 50402035 CHEMBL2205455 Serine/threonine-protein kinase PLK1 Homo sapiens 8530 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402035&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454130 163351059 CHEMBL2205455 ZINC95560338 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980767 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3csnn3)n2)c(=O)c1=O InChI=1S/C20H19N7O2S/c1-20(2,3)25-16-15(17(28)18(16)29)23-14-8-9-21-19(24-14)22-12-6-4-11(5-7-12)13-10-30-27-26-13/h4-10,25H,1-3H3,(H2,21,22,23,24) CAJJNCAGEREFPG-UHFFFAOYSA-N 50402036 CHEMBL2205461 Serine/threonine-protein kinase PLK1 Homo sapiens 8320 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402036&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461304 163351060 CHEMBL2205461 ZINC95559399 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980768 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccn3)n2)c(=O)c1=O InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-11-13-25-22(28-17)26-15-9-7-14(8-10-15)16-6-4-5-12-24-16/h4-13,29H,1-3H3,(H2,25,26,27,28) RKTITQZFTQXTSL-UHFFFAOYSA-N 50402037 CHEMBL2205424 Serine/threonine-protein kinase PLK1 Homo sapiens 8280 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402037&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463026 163351061 CHEMBL2205424 ZINC68087746 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980769 COc1cc(Nc2ncc(C#N)c(Nc3c(N[C@H](C)C(C)(C)C)c(=O)c3=O)n2)cc(OC)c1OC InChI=1S/C24H28N6O5/c1-12(24(2,3)4)27-17-18(20(32)19(17)31)29-22-13(10-25)11-26-23(30-22)28-14-8-15(33-5)21(35-7)16(9-14)34-6/h8-9,11-12,27H,1-7H3,(H2,26,28,29,30)/t12-/m1/s1 JFKYVVBOEQNVTQ-GFCCVEGCSA-N 50402038 CHEMBL2205459 Serine/threonine-protein kinase PLK1 Homo sapiens 7720 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402038&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450504 163351062 CHEMBL2205459 ZINC95562647 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980772 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4c(c3)[nH]c3ccccc43)n2)c(=O)c1=O InChI=1S/C24H22N6O2/c1-24(2,3)30-20-19(21(31)22(20)32)28-18-10-11-25-23(29-18)26-13-8-9-15-14-6-4-5-7-16(14)27-17(15)12-13/h4-12,27,30H,1-3H3,(H2,25,26,28,29) FVABLEGORONDAP-UHFFFAOYSA-N 50402039 CHEMBL2205462 Serine/threonine-protein kinase PLK1 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402039&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459560 163351063 CHEMBL2205462 ZINC95562564 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980776 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4OCCc4c3)n2)c(=O)c1=O InChI=1S/C20H21N5O3/c1-20(2,3)25-16-15(17(26)18(16)27)23-14-6-8-21-19(24-14)22-12-4-5-13-11(10-12)7-9-28-13/h4-6,8,10,25H,7,9H2,1-3H3,(H2,21,22,23,24) YXKNRJOHAQUYHN-UHFFFAOYSA-N 50402040 CHEMBL2205465 Serine/threonine-protein kinase PLK1 Homo sapiens 2860 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402040&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459561 163351064 CHEMBL2205465 ZINC95560580 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980777 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4ncsc4c3)n2)c(=O)c1=O InChI=1S/C19H18N6O2S/c1-19(2,3)25-15-14(16(26)17(15)27)23-13-6-7-20-18(24-13)22-10-4-5-11-12(8-10)28-9-21-11/h4-9,25H,1-3H3,(H2,20,22,23,24) VDGBGQVBOFMCSF-UHFFFAOYSA-N 50402041 CHEMBL2205464 Serine/threonine-protein kinase PLK1 Homo sapiens 2860 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402041&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450505 163351065 CHEMBL2205464 ZINC95559846 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980781 CC(C)(C)CNc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O InChI=1S/C25H25N5O2/c1-25(2,3)15-27-20-21(23(32)22(20)31)29-19-13-14-26-24(30-19)28-18-11-9-17(10-12-18)16-7-5-4-6-8-16/h4-14,27H,15H2,1-3H3,(H2,26,28,29,30) NCBMAIPCPSCCLT-UHFFFAOYSA-N 50402043 CHEMBL2205449 Serine/threonine-protein kinase PLK1 Homo sapiens 1800 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402043&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71455861 163351067 CHEMBL2205449 ZINC95561926 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980788 CC(C)CC(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O InChI=1S/C26H27N5O2/c1-16(2)15-17(3)28-22-23(25(33)24(22)32)30-21-13-14-27-26(31-21)29-20-11-9-19(10-12-20)18-7-5-4-6-8-18/h4-14,16-17,28H,15H2,1-3H3,(H2,27,29,30,31) WTKIRFQEEITPQK-UHFFFAOYSA-N 50402047 CHEMBL2205451 Serine/threonine-protein kinase PLK1 Homo sapiens 1180 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402047&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454129 163351071 CHEMBL2205451 ZINC95559837 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980789 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-13-25-22(28-17)26-16-6-4-14(5-7-16)15-8-11-24-12-9-15/h4-13,29H,1-3H3,(H2,25,26,27,28) NDIUYMHNCUTVGE-UHFFFAOYSA-N 50402020 CHEMBL2205426 Serine/threonine-protein kinase PLK1 Homo sapiens 1050 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402020&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71455860 163351044 CHEMBL2205426 ZINC95563476 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980790 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(C)cc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C21H25N5O2/c1-12-6-8-14(9-7-12)24-20-22-11-10-15(26-20)25-17-16(18(27)19(17)28)23-13(2)21(3,4)5/h6-11,13,23H,1-5H3,(H2,22,24,25,26)/t13-/m1/s1 GVZWLEOXAKEWHB-CYBMUJFWSA-N 50402048 CHEMBL2205429 Serine/threonine-protein kinase PLK1 Homo sapiens 1010 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402048&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457662 163351072 CHEMBL2205429 ZINC95561276 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980792 COc1ccc(Nc2nccc(Nc3c(N[C@H](C)C(C)(C)C)c(=O)c3=O)n2)c(OC)c1 InChI=1S/C22H27N5O4/c1-12(22(2,3)4)24-17-18(20(29)19(17)28)26-16-9-10-23-21(27-16)25-14-8-7-13(30-5)11-15(14)31-6/h7-12,24H,1-6H3,(H2,23,25,26,27)/t12-/m1/s1 ZDQVQXYWGRWPHB-GFCCVEGCSA-N 50402049 CHEMBL2205435 Serine/threonine-protein kinase PLK1 Homo sapiens 771 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402049&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24864855 163351073 CHEMBL2205435 ZINC95561039 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980794 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(OC(F)(F)F)cc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C21H22F3N5O3/c1-11(20(2,3)4)26-15-16(18(31)17(15)30)28-14-9-10-25-19(29-14)27-12-5-7-13(8-6-12)32-21(22,23)24/h5-11,26H,1-4H3,(H2,25,27,28,29)/t11-/m1/s1 DYNAFCVVACBSAO-LLVKDONJSA-N 50402050 CHEMBL2205433 Serine/threonine-protein kinase PLK1 Homo sapiens 610 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402050&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24865034 163351074 CHEMBL2205433 ZINC95560242 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980796 C[C@@H](Nc1c(Nc2ccnc(Nc3ccccc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C20H23N5O2/c1-12(20(2,3)4)22-15-16(18(27)17(15)26)24-14-10-11-21-19(25-14)23-13-8-6-5-7-9-13/h5-12,22H,1-4H3,(H2,21,23,24,25)/t12-/m1/s1 XEPATAODVVYZFR-GFCCVEGCSA-N 50402051 CHEMBL2205428 Serine/threonine-protein kinase PLK1 Homo sapiens 465 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402051&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24864678 163351075 CHEMBL2205428 ZINC95558923 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980799 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(Br)cc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C20H22BrN5O2/c1-11(20(2,3)4)23-15-16(18(28)17(15)27)25-14-9-10-22-19(26-14)24-13-7-5-12(21)6-8-13/h5-11,23H,1-4H3,(H2,22,24,25,26)/t11-/m1/s1 SZCZWWAYTCJULU-LLVKDONJSA-N 50402052 CHEMBL2205432 Serine/threonine-protein kinase PLK1 Homo sapiens 354 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402052&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24864675 163351076 CHEMBL2205432 ZINC95561076 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980801 C[C@@H](Nc1c(Nc2ccnc(Nc3cccc(c3)-c3ccccc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C26H27N5O2/c1-16(26(2,3)4)28-21-22(24(33)23(21)32)30-20-13-14-27-25(31-20)29-19-12-8-11-18(15-19)17-9-6-5-7-10-17/h5-16,28H,1-4H3,(H2,27,29,30,31)/t16-/m1/s1 BHRSRFFFURQFRF-MRXNPFEDSA-N 50402053 CHEMBL2205446 Serine/threonine-protein kinase PLK1 Homo sapiens 333 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463028 163351077 CHEMBL2205446 ZINC95561329 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980803 C[C@@H](Nc1c(Nc2ccnc(Nc3cccc4ccccc34)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C24H25N5O2/c1-14(24(2,3)4)26-19-20(22(31)21(19)30)28-18-12-13-25-23(29-18)27-17-11-7-9-15-8-5-6-10-16(15)17/h5-14,26H,1-4H3,(H2,25,27,28,29)/t14-/m1/s1 AFAFROPKFQYWSF-CQSZACIVSA-N 50402054 CHEMBL2205442 Serine/threonine-protein kinase PLK1 Homo sapiens 315 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402054&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71452346 163351078 CHEMBL2205442 ZINC95562187 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980804 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(Oc4ccccc4)cc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C26H27N5O3/c1-16(26(2,3)4)28-21-22(24(33)23(21)32)30-20-14-15-27-25(31-20)29-17-10-12-19(13-11-17)34-18-8-6-5-7-9-18/h5-16,28H,1-4H3,(H2,27,29,30,31)/t16-/m1/s1 YOXBNEGMQSOWJD-MRXNPFEDSA-N 50402055 CHEMBL2205447 Serine/threonine-protein kinase PLK1 Homo sapiens 276 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402055&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463029 163351079 CHEMBL2205447 ZINC95561723 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980805 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(Cl)cc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C20H22ClN5O2/c1-11(20(2,3)4)23-15-16(18(28)17(15)27)25-14-9-10-22-19(26-14)24-13-7-5-12(21)6-8-13/h5-11,23H,1-4H3,(H2,22,24,25,26)/t11-/m1/s1 SSAPLLOWEWCVKP-LLVKDONJSA-N 50402056 CHEMBL2205431 Serine/threonine-protein kinase PLK1 Homo sapiens 272 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402056&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24864677 163351080 CHEMBL2205431 ZINC68087743 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980808 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc4OCCOc4c3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C22H25N5O4/c1-12(22(2,3)4)24-17-18(20(29)19(17)28)26-16-7-8-23-21(27-16)25-13-5-6-14-15(11-13)31-10-9-30-14/h5-8,11-12,24H,9-10H2,1-4H3,(H2,23,25,26,27)/t12-/m1/s1 XQRLMQBTZIUURY-GFCCVEGCSA-N 50402057 CHEMBL2205437 Serine/threonine-protein kinase PLK1 Homo sapiens 255 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402057&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454128 163351081 CHEMBL2205437 ZINC95562871 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980809 COc1cc(Nc2nccc(Nc3c(N[C@H](C)C(C)(C)C)c(=O)c3=O)n2)cc(OC)c1OC InChI=1S/C23H29N5O5/c1-12(23(2,3)4)25-17-18(20(30)19(17)29)27-16-8-9-24-22(28-16)26-13-10-14(31-5)21(33-7)15(11-13)32-6/h8-12,25H,1-7H3,(H2,24,26,27,28)/t12-/m1/s1 MVZRHVDFODTTPE-GFCCVEGCSA-N 50402058 CHEMBL2205427 Serine/threonine-protein kinase PLK1 Homo sapiens 234 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402058&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 23624256 163351082 CHEMBL2205427 ZINC95559852 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980810 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(F)cc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C20H22FN5O2/c1-11(20(2,3)4)23-15-16(18(28)17(15)27)25-14-9-10-22-19(26-14)24-13-7-5-12(21)6-8-13/h5-11,23H,1-4H3,(H2,22,24,25,26)/t11-/m1/s1 QYCGFWZASFGLTC-LLVKDONJSA-N 50402059 CHEMBL2205430 Serine/threonine-protein kinase PLK1 Homo sapiens 232 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402059&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461301 163351083 CHEMBL2205430 ZINC95563886 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980816 CC(C)C(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O InChI=1S/C25H25N5O2/c1-15(2)16(3)27-21-22(24(32)23(21)31)29-20-13-14-26-25(30-20)28-19-11-9-18(10-12-19)17-7-5-4-6-8-17/h4-16,27H,1-3H3,(H2,26,28,29,30) BJNKDKLJGNNUHU-UHFFFAOYSA-N 50402060 CHEMBL2205450 Serine/threonine-protein kinase PLK1 Homo sapiens 166 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402060&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71455862 163351084 CHEMBL2205450 ZINC95560896 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980817 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc4OCOc4c3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C21H23N5O4/c1-11(21(2,3)4)23-16-17(19(28)18(16)27)25-15-7-8-22-20(26-15)24-12-5-6-13-14(9-12)30-10-29-13/h5-9,11,23H,10H2,1-4H3,(H2,22,24,25,26)/t11-/m1/s1 SYIDJVCIQZEKSO-LLVKDONJSA-N 50402061 CHEMBL2205436 Serine/threonine-protein kinase PLK1 Homo sapiens 165 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402061&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457663 163351085 CHEMBL2205436 ZINC95563441 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980818 COc1ccc(Nc2nccc(Nc3c(N[C@H](C)C(C)(C)C)c(=O)c3=O)n2)cc1 InChI=1S/C21H25N5O3/c1-12(21(2,3)4)23-16-17(19(28)18(16)27)25-15-10-11-22-20(26-15)24-13-6-8-14(29-5)9-7-13/h6-12,23H,1-5H3,(H2,22,24,25,26)/t12-/m1/s1 JFKLAOWZZRXMHI-GFCCVEGCSA-N 50402062 CHEMBL2205434 Serine/threonine-protein kinase PLK1 Homo sapiens 141 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402062&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24865032 163351086 CHEMBL2205434 ZINC95558941 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980822 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc4ccccc4c3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C24H25N5O2/c1-14(24(2,3)4)26-19-20(22(31)21(19)30)28-18-11-12-25-23(29-18)27-17-10-9-15-7-5-6-8-16(15)13-17/h5-14,26H,1-4H3,(H2,25,27,28,29)/t14-/m1/s1 SKIQDRWTRDIVMT-CQSZACIVSA-N 50402063 CHEMBL2205443 Serine/threonine-protein kinase PLK1 Homo sapiens 85 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402063&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463027 163351087 CHEMBL2205443 ZINC95564244 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980824 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C26H27N5O2/c1-16(26(2,3)4)28-21-22(24(33)23(21)32)30-20-14-15-27-25(31-20)29-19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-16,28H,1-4H3,(H2,27,29,30,31)/t16-/m1/s1 HPJJYTDVYAAQIR-MRXNPFEDSA-N 50402064 CHEMBL2205444 Serine/threonine-protein kinase PLK1 Homo sapiens 75 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402064&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459559 163351088 CHEMBL2205444 ZINC95561912 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980826 C[C@H](Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C26H27N5O2/c1-16(26(2,3)4)28-21-22(24(33)23(21)32)30-20-14-15-27-25(31-20)29-19-12-10-18(11-13-19)17-8-6-5-7-9-17/h5-16,28H,1-4H3,(H2,27,29,30,31)/t16-/m0/s1 HPJJYTDVYAAQIR-INIZCTEOSA-N 50402065 CHEMBL2205448 Serine/threonine-protein kinase PLK1 Homo sapiens 47 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402065&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461302 163351089 CHEMBL2205448 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980828 C[C@@H](Nc1c(Nc2ccnc(Nc3ccc-4c(Cc5ccccc-45)c3)n2)c(=O)c1=O)C(C)(C)C InChI=1S/C27H27N5O2/c1-15(27(2,3)4)29-22-23(25(34)24(22)33)31-21-11-12-28-26(32-21)30-18-9-10-20-17(14-18)13-16-7-5-6-8-19(16)20/h5-12,14-15,29H,13H2,1-4H3,(H2,28,30,31,32)/t15-/m1/s1 MGBVVXGXAHXCJD-OAHLLOKOSA-N 50402066 CHEMBL2205445 Serine/threonine-protein kinase PLK1 Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402066&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457664 163351090 CHEMBL2205445 ZINC95564055 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980829 C[C@@H](Nc1c(Nc2ccccc2)c(=O)c1=O)C(C)(C)C InChI=1S/C16H20N2O2/c1-10(16(2,3)4)17-12-13(15(20)14(12)19)18-11-8-6-5-7-9-11/h5-10,17-18H,1-4H3/t10-/m1/s1 PBZCGYPOKVOUJC-SNVBAGLBSA-N 50402067 CHEMBL2205467 Serine/threonine-protein kinase PLK1 Homo sapiens 32000 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402067&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10849808 163351091 CHEMBL2205467 ZINC95563656 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980833 CC(=O)N1CCc2cc(Nc3nccc(Nc4c(NC(C)(C)C)c(=O)c4=O)n3)ccc12 InChI=1S/C22H24N6O3/c1-12(29)28-10-8-13-11-14(5-6-15(13)28)24-21-23-9-7-16(26-21)25-17-18(20(31)19(17)30)27-22(2,3)4/h5-7,9,11,27H,8,10H2,1-4H3,(H2,23,24,25,26) MJCBPVVQRZZEGT-UHFFFAOYSA-N 50402045 CHEMBL2205422 Serine/threonine-protein kinase PLK1 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402045&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463025 163351069 CHEMBL2205422 ZINC95563830 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980834 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc4[nH]ncc4c3)n2)c(=O)c1=O InChI=1S/C19H19N7O2/c1-19(2,3)25-15-14(16(27)17(15)28)23-13-6-7-20-18(24-13)22-11-4-5-12-10(8-11)9-21-26-12/h4-9,25H,1-3H3,(H,21,26)(H2,20,22,23,24) GEWGELYHGXTZQJ-UHFFFAOYSA-N 50402046 CHEMBL2205466 Serine/threonine-protein kinase PLK1 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402046&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71463030 163351070 CHEMBL2205466 ZINC95562272 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980838 CCC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccccc3)n2)c(=O)c1=O InChI=1S/C25H25N5O2/c1-4-25(2,3)30-21-20(22(31)23(21)32)28-19-14-15-26-24(29-19)27-18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,30H,4H2,1-3H3,(H2,26,27,28,29) QRVHCAPXFAIDOD-UHFFFAOYSA-N 50402068 CHEMBL2205456 Serine/threonine-protein kinase PLK1 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402068&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454131 163351092 CHEMBL2205456 ZINC95561105 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980839 COc1cc(Nc2ncc(c(Nc3ccccc3C(N)=O)n2)[N+]([O-])=O)cc(OC)c1OC InChI=1S/C20H20N6O6/c1-30-15-8-11(9-16(31-2)17(15)32-3)23-20-22-10-14(26(28)29)19(25-20)24-13-7-5-4-6-12(13)18(21)27/h4-10H,1-3H3,(H2,21,27)(H2,22,23,24,25) FLEAYYMORDPWAJ-UHFFFAOYSA-N 50402069 CHEMBL1241473 Serine/threonine-protein kinase PLK1 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402069&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9891182 163351093 CHEMBL1241473 ZINC03986637 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980840 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cn[nH]c3)n2)c(=O)c1=O InChI=1S/C21H21N7O2/c1-21(2,3)28-17-16(18(29)19(17)30)26-15-8-9-22-20(27-15)25-14-6-4-12(5-7-14)13-10-23-24-11-13/h4-11,28H,1-3H3,(H,23,24)(H2,22,25,26,27) FRNPTMFJLAHUDE-UHFFFAOYSA-N 50402044 CHEMBL2205423 Serine/threonine-protein kinase PLK1 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402044&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71452343 163351068 CHEMBL2205423 ZINC95561477 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50980778 CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3cccnc3)n2)c(=O)c1=O InChI=1S/C23H22N6O2/c1-23(2,3)29-19-18(20(30)21(19)31)27-17-10-12-25-22(28-17)26-16-8-6-14(7-9-16)15-5-4-11-24-13-15/h4-13,29H,1-3H3,(H2,25,26,27,28) KKOLAOXXRFMPDD-UHFFFAOYSA-N 50402042 CHEMBL2205425 Serine/threonine-protein kinase PLK1 Homo sapiens 2550 ChEMBL 10.1016/j.bmcl.2012.10.009 10.7270/Q2XK8GQ3 23103095 Zhang, Q; Xia, Z; Mitten, MJ; Lasko, LM; Klinghofer, V; Bouska, J; Johnson, EF; Penning, TD; Luo, Y; Giranda, VL; Shoemaker, AR; Stewart, KD; Djuric, SW; Vasudevan, A Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402042&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457661 163351066 CHEMBL2205425 ZINC95564201 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50974778 CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1 InChI=1S/C27H32N8/c1-33-15-17-34(18-16-33)22-13-11-21(12-14-22)29-26-28-19-24-25(32-26)35(23-9-5-6-10-23)27(31-24)30-20-7-3-2-4-8-20/h2-4,7-8,11-14,19,23H,5-6,9-10,15-18H2,1H3,(H,30,31)(H,28,29,32) QPOURHROVVCOHC-UHFFFAOYSA-N 50399676 CHEMBL2178352::US9096601, 8-26 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm301365e 10.7270/Q2251KBV 23116168 Yang, J; Wang, LJ; Liu, JJ; Zhong, L; Zheng, RL; Xu, Y; Ji, P; Zhang, CH; Wang, WJ; Lin, XD; Li, LL; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399676&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7XR 5X2C,5X27 54760383 163348700 CHEMBL2178352 ZINC95580356 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982813 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCCCNC(=O)CCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C38H62N7O12P/c1-24(2)22-29(42-38(53)31-18-13-21-45(31)26(4)47)36(51)41-28(17-11-12-20-40-32(48)19-10-6-9-16-27-14-7-5-8-15-27)35(50)43-30(23-46)37(52)44-33(34(39)49)25(3)57-58(54,55)56/h5,7-8,14-15,24-25,28-31,33,46H,6,9-13,16-23H2,1-4H3,(H2,39,49)(H,40,48)(H,41,51)(H,42,53)(H,43,50)(H,44,52)(H2,54,55,56)/t25-,28+,29+,30+,31+,33+/m1/s1 VQIOLOBSXRKEAP-KIUCONSDSA-N 50403010 CHEMBL2207839 Serine/threonine-protein kinase PLK1 Homo sapiens 650 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403010&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461491 163352034 CHEMBL2207839 ZINC95557801 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982814 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCCNC(=O)CCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C39H64N7O12P/c1-25(2)23-30(43-39(54)32-19-14-22-46(32)27(4)48)37(52)42-29(18-13-21-41-33(49)20-12-7-5-6-9-15-28-16-10-8-11-17-28)36(51)44-31(24-47)38(53)45-34(35(40)50)26(3)58-59(55,56)57/h8,10-11,16-17,25-26,29-32,34,47H,5-7,9,12-15,18-24H2,1-4H3,(H2,40,50)(H,41,49)(H,42,52)(H,43,54)(H,44,51)(H,45,53)(H2,55,56,57)/t26-,29+,30+,31+,32+,34+/m1/s1 LNHXIPPBAPMRIE-AYTHIJHQSA-N 50403011 CHEMBL2207840 Serine/threonine-protein kinase PLK1 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403011&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454309 163352035 CHEMBL2207840 ZINC95563715 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982815 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCC(=O)NCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C38H62N7O12P/c1-24(2)22-29(42-38(53)31-17-13-21-45(31)26(4)47)36(51)41-28(18-19-32(48)40-20-12-7-5-6-9-14-27-15-10-8-11-16-27)35(50)43-30(23-46)37(52)44-33(34(39)49)25(3)57-58(54,55)56/h8,10-11,15-16,24-25,28-31,33,46H,5-7,9,12-14,17-23H2,1-4H3,(H2,39,49)(H,40,48)(H,41,51)(H,42,53)(H,43,50)(H,44,52)(H2,54,55,56)/t25-,28+,29+,30+,31+,33+/m1/s1 UQVVKCSRCFXOOS-KIUCONSDSA-N 50403012 CHEMBL2207841 Serine/threonine-protein kinase PLK1 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403012&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459769 163352036 CHEMBL2207841 C03636 ZINC95561488 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982816 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CC(=O)NCCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C38H62N7O12P/c1-24(2)21-28(42-38(53)31-18-14-20-45(31)26(4)47)35(50)41-29(22-32(48)40-19-13-8-6-5-7-10-15-27-16-11-9-12-17-27)36(51)43-30(23-46)37(52)44-33(34(39)49)25(3)57-58(54,55)56/h9,11-12,16-17,24-25,28-31,33,46H,5-8,10,13-15,18-23H2,1-4H3,(H2,39,49)(H,40,48)(H,41,50)(H,42,53)(H,43,51)(H,44,52)(H2,54,55,56)/t25-,28+,29+,30+,31+,33+/m1/s1 WGXULIDEUYMONG-KIUCONSDSA-N 50403013 CHEMBL2207842 Serine/threonine-protein kinase PLK1 Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403013&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450724 163352037 CHEMBL2207842 ZINC95559426 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982817 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cn(CCCCCCCCc2ccccc2)c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C45H66N7O11P/c1-29(2)25-35(48-45(59)39-22-16-24-52(39)31(4)54)42(56)47-36(43(57)49-37(28-53)44(58)50-40(41(46)55)30(3)63-64(60,61)62)26-33-27-51(38-21-14-13-20-34(33)38)23-15-8-6-5-7-10-17-32-18-11-9-12-19-32/h9,11-14,18-21,27,29-30,35-37,39-40,53H,5-8,10,15-17,22-26,28H2,1-4H3,(H2,46,55)(H,47,56)(H,48,59)(H,49,57)(H,50,58)(H2,60,61,62)/t30-,35+,36+,37+,39+,40+/m1/s1 OYUCIHXKLQGOKP-WYEJJTDISA-N 50403014 CHEMBL2207843 Serine/threonine-protein kinase PLK1 Homo sapiens 9300 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403014&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461492 163352038 CHEMBL2207843 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982818 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cn(CCCCCCCCc2ccccc2)cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-47(25-42-30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 CZPWZRXIYDNNLI-BKXCAEITSA-N 50403015 CHEMBL2207844 Serine/threonine-protein kinase PLK1 Homo sapiens 320 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403015&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71457857 163352039 CHEMBL2207844 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982819 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 5.6 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50982820 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 UIYQCJDQBRUFEV-FALOATQWSA-N 50403017 CHEMBL2207846 Serine/threonine-protein kinase PLK1 Homo sapiens 16000 ChEMBL 10.1016/j.bmcl.2012.10.093 10.7270/Q2Z89DK2 23159568 Qian, WJ; Park, JE; Lee, KS; Burke, TR Frederick National Laboratory for Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49873221 163352041 CHEMBL2207846 ZINC95564030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51046207 Cc1cc(-c2ccc(cc2)C#N)c(OCCO)c(c1)-c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C23H19N5O2/c1-15-12-20(17-4-2-16(14-24)3-5-17)22(30-11-10-29)21(13-15)18-6-8-19(9-7-18)23-25-27-28-26-23/h2-9,12-13,29H,10-11H2,1H3,(H,25,26,27,28) FXFITXFZTUYDTA-UHFFFAOYSA-N 50426930 CHEMBL2324036 Serine/threonine-protein kinase PLK1 Homo sapiens 151000 ChEMBL 10.1016/j.bmc.2012.11.054 10.7270/Q2QZ2C94 23276450 Mita, Y; Noguchi-Yachide, T; Ishikawa, M; Hashimoto, Y The University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71524012 164155805 CHEMBL2324036 ZINC95581534 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51046208 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 IYLBMSHZRRWSRM-FALOATQWSA-N 50426931 CHEMBL2323729 Serine/threonine-protein kinase PLK1 Homo sapiens 5270 ChEMBL 10.1016/j.bmc.2012.11.054 10.7270/Q2QZ2C94 23276450 Mita, Y; Noguchi-Yachide, T; Ishikawa, M; Hashimoto, Y The University of Tokyo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42608451 164155806 CHEMBL2323729 ZINC95584623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51052983 FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ncnc4n[nH]cc34)cc2)ccc1Cl InChI=1S/C19H12ClF3N6O2/c20-15-6-3-11(7-14(15)19(21,22)23)28-18(30)27-10-1-4-12(5-2-10)31-17-13-8-26-29-16(13)24-9-25-17/h1-9H,(H2,27,28,30)(H,24,25,26,29) NZCHGHMPHKCWLR-UHFFFAOYSA-N 50429477 CHEMBL2332840 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm301537p 10.7270/Q29S1SC5 23362959 Yang, LL; Li, GB; Ma, S; Zou, C; Zhou, S; Sun, QZ; Cheng, C; Chen, X; Wang, LJ; Feng, S; Li, LL; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429477&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71575642 164158352 CHEMBL2332840 ZINC95589656 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51054171 Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) LNFBAYSBVQBKFR-UHFFFAOYSA-N 50429867 CHEMBL2333365 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm3007933 10.7270/Q2ZC847X 23394126 Takeuchi, CS; Kim, BG; Blazey, CM; Ma, S; Johnson, HW; Anand, NK; Arcalas, A; Baik, TG; Buhr, CA; Cannoy, J; Epshteyn, S; Joshi, A; Lara, K; Lee, MS; Wang, L; Leahy, JW; Nuss, JM; Aay, N; Aoyama, R; Foster, P; Lee, J; Lehoux, I; Munagala, N; Plonowski, A; Rajan, S; Woolfrey, J; Yamaguchi, K; Lamb, P; Miller, N Exelixis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429867&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 59604787 164158742 CHEMBL2333365 ZINC95550928 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51051126 Oc1ccc(CCNC(=O)C(Cc2cc(Br)c(O)c(Oc3ccc(CCNC(=O)C(Cc4cc(Br)c(O)c(c4)-c4cc(CC(N=O)C(=O)NCCc5ccc(O)c(Br)c5)cc(Br)c4O)N=O)cc3Br)c2)N=O)cc1Br InChI=1S/C51H44Br6N6O12/c52-33-15-25(1-4-42(33)64)7-10-58-49(69)39(61-72)21-28-13-31(46(66)36(55)18-28)32-14-29(19-37(56)47(32)67)22-40(62-73)50(70)60-12-9-27-3-6-44(35(54)17-27)75-45-24-30(20-38(57)48(45)68)23-41(63-74)51(71)59-11-8-26-2-5-43(65)34(53)16-26/h1-6,13-20,24,39-41,64-68H,7-12,21-23H2,(H,58,69)(H,59,71)(H,60,70) HJVFTUSVRMGBLM-UHFFFAOYSA-N 50428738 CHEMBL2333163::Sesquibastadin 1 Serine/threonine-protein kinase PLK1 Homo sapiens 6400 ChEMBL 10.1021/np300764u 10.7270/Q21N82F5 23249297 Niemann, H; Lin, W; Muller, WE; Kubbutat, M; Lai, D; Proksch, P Heinrich-Heine University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428738&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91900035 164157613 CHEMBL2333163 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51051127 Oc1ccc(CCNC(=O)C(Cc2cc(Br)c(O)c(c2)-c2cc(CC(N=O)C(=O)NCCc3ccc(O)c(Br)c3)cc(Br)c2O)N=O)cc1Br InChI=1S/C34H30Br4N4O8/c35-23-11-17(1-3-29(23)43)5-7-39-33(47)27(41-49)15-19-9-21(31(45)25(37)13-19)22-10-20(14-26(38)32(22)46)16-28(42-50)34(48)40-8-6-18-2-4-30(44)24(36)12-18/h1-4,9-14,27-28,43-46H,5-8,15-16H2,(H,39,47)(H,40,48) KSBCGWKXTJXPLL-UHFFFAOYSA-N 50428737 BASTADIN 3 Serine/threonine-protein kinase PLK1 Homo sapiens 3900 ChEMBL 10.1021/np300764u 10.7270/Q21N82F5 23249297 Niemann, H; Lin, W; Muller, WE; Kubbutat, M; Lai, D; Proksch, P Heinrich-Heine University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50428737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50428737&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91900034 164157612 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51004192 O=C(Nc1sc2N(CCCc2c1C#N)C(=O)C1CC1)c1cccc2ccccc12 InChI=1S/C23H19N3O2S/c24-13-19-18-9-4-12-26(22(28)15-10-11-15)23(18)29-21(19)25-20(27)17-8-3-6-14-5-1-2-7-16(14)17/h1-3,5-8,15H,4,9-12H2,(H,25,27) KTBZRPANEUUZDW-UHFFFAOYSA-N 50411406 CHEMBL232601 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411406&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16664858 163360430 CHEMBL232601 ZINC28821925 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51004247 O=C(Nc1sc2CCCCc2c1C#N)c1cccc2ccccc12 InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23) WQGDQGAFSDMBLA-UHFFFAOYSA-N 86638 Name not given Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86638&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 766949 136352687 ZINC00244029 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521340 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C\c1csc(n1)N(C(C)=O)c1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C44H64N11O13PS/c1-27(2)20-34(50-43(63)37-16-13-18-54(37)29(4)57)40(60)49-35(41(61)51-36(24-56)42(62)52-38(39(45)59)28(3)68-69(64,65)66)21-33-23-46-26-53(33)17-11-6-7-12-19-67-47-22-31-25-70-44(48-31)55(30(5)58)32-14-9-8-10-15-32/h8-10,14-15,22-23,25-28,34-38,56H,6-7,11-13,16-21,24H2,1-5H3,(H2,45,59)(H,49,60)(H,50,63)(H,51,61)(H,52,62)(H2,64,65,66)/b47-22+/t28-,34+,35+,36+,37+,38+/m1/s1 FSCIFRALUGPNIF-VUIPXDDYSA-N 50194928 CHEMBL3909741 Serine/threonine-protein kinase PLK1 Homo sapiens 164 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194928&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134132792 375977035 CHEMBL3909741 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521341 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C\c1cccn1-c1nccc(n1)-c1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C45H63N12O12PS/c1-28(2)22-34(51-44(64)37-13-10-18-56(37)30(4)59)41(61)50-35(42(62)52-36(26-58)43(63)54-39(40(46)60)29(3)69-70(65,66)67)23-32-24-47-27-55(32)17-7-5-6-8-20-68-49-25-31-12-9-19-57(31)45-48-16-15-33(53-45)38-14-11-21-71-38/h9,11-12,14-16,19,21,24-25,27-29,34-37,39,58H,5-8,10,13,17-18,20,22-23,26H2,1-4H3,(H2,46,60)(H,50,61)(H,51,64)(H,52,62)(H,54,63)(H2,65,66,67)/b49-25+/t29-,34+,35+,36+,37+,39+/m1/s1 RZLIRASVOYQCEI-VPGGRGEMSA-N 50194929 CHEMBL3953093 Serine/threonine-protein kinase PLK1 Homo sapiens 94 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194929&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134143807 375977036 CHEMBL3953093 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521342 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C\c1ccccc1-c1ccc(F)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C45H63FN9O12P/c1-28(2)22-36(51-45(62)39-14-11-20-55(39)30(4)57)42(59)50-37(43(60)52-38(26-56)44(61)53-40(41(47)58)29(3)67-68(63,64)65)23-34-25-48-27-54(34)19-9-5-6-10-21-66-49-24-32-12-7-8-13-35(32)31-15-17-33(46)18-16-31/h7-8,12-13,15-18,24-25,27-29,36-40,56H,5-6,9-11,14,19-23,26H2,1-4H3,(H2,47,58)(H,50,59)(H,51,62)(H,52,60)(H,53,61)(H2,63,64,65)/b49-24+/t29-,36+,37+,38+,39+,40+/m1/s1 YDADPNOVOQSBSB-LPQCQSQESA-N 50194930 CHEMBL3979907 Serine/threonine-protein kinase PLK1 Homo sapiens 186 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134152223 375977037 CHEMBL3979907 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521343 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCO\N=C\c1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C44H61FN9O13P/c1-27(2)21-34(50-44(61)37-16-12-19-54(37)29(4)56)41(58)49-35(42(59)51-36(25-55)43(60)52-39(40(46)57)28(3)67-68(62,63)64)22-30-23-47-26-53(30)18-9-6-10-20-65-48-24-32-33(45)15-11-17-38(32)66-31-13-7-5-8-14-31/h5,7-8,11,13-15,17,23-24,26-28,34-37,39,55H,6,9-10,12,16,18-22,25H2,1-4H3,(H2,46,57)(H,49,58)(H,50,61)(H,51,59)(H,52,60)(H2,62,63,64)/b48-24+/t28-,34+,35+,36+,37+,39+/m1/s1 QINOMHBLNDVOTP-GXQKTUKWSA-N 50194931 CHEMBL3944723 Serine/threonine-protein kinase PLK1 Homo sapiens 1550 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134146150 104077103 CHEMBL3944723 ZINC03942872 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521344 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C\c1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C39H60N9O12P/c1-25(2)19-30(44-39(55)33-15-12-17-48(33)27(4)50)36(52)43-31(37(53)45-32(23-49)38(54)46-34(35(40)51)26(3)60-61(56,57)58)20-29-22-41-24-47(29)16-10-5-6-11-18-59-42-21-28-13-8-7-9-14-28/h7-9,13-14,21-22,24-26,30-34,49H,5-6,10-12,15-20,23H2,1-4H3,(H2,40,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/b42-21+/t26-,30+,31+,32+,33+,34+/m1/s1 KJQNIUMZTBTNPM-TYYMDPTCSA-N 50194932 CHEMBL3921057 Serine/threonine-protein kinase PLK1 Homo sapiens 558 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134139987 375977038 CHEMBL3921057 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521345 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C46H66FN8O12P/c1-29(2)24-36(51-46(62)39-20-15-23-55(39)31(4)57)43(59)50-37(44(60)52-38(27-56)45(61)53-41(42(48)58)30(3)67-68(63,64)65)25-32-26-49-28-54(32)22-13-8-6-5-7-12-18-34-35(47)19-14-21-40(34)66-33-16-10-9-11-17-33/h9-11,14,16-17,19,21,26,28-30,36-39,41,56H,5-8,12-13,15,18,20,22-25,27H2,1-4H3,(H2,48,58)(H,50,59)(H,51,62)(H,52,60)(H,53,61)(H2,63,64,65)/t30-,36+,37+,38+,39+,41+/m1/s1 XDRHCUWKZRZSEP-CQKJNDIKSA-N 50194933 CHEMBL3956625 Serine/threonine-protein kinase PLK1 Homo sapiens 66 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194933&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134143682 375977039 CHEMBL3956625 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521346 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C\c1cc(Cl)ccc1OCc1ccccn1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C45H64ClN10O13P/c1-28(2)20-35(52-45(63)38-13-11-18-56(38)30(4)58)42(60)51-36(43(61)53-37(25-57)44(62)54-40(41(47)59)29(3)69-70(64,65)66)22-34-24-48-27-55(34)17-9-5-6-10-19-68-50-23-31-21-32(46)14-15-39(31)67-26-33-12-7-8-16-49-33/h7-8,12,14-16,21,23-24,27-29,35-38,40,57H,5-6,9-11,13,17-20,22,25-26H2,1-4H3,(H2,47,59)(H,51,60)(H,52,63)(H,53,61)(H,54,62)(H2,64,65,66)/b50-23+/t29-,35+,36+,37+,38+,40+/m1/s1 WXWYPJSPBYNUSZ-IRBCDZGCSA-N 50194935 CHEMBL3950880 Serine/threonine-protein kinase PLK1 Homo sapiens 149 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194935&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134147429 375977040 CHEMBL3950880 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521347 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C/c1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C45H63FN9O13P/c1-28(2)22-35(51-45(62)38-17-13-20-55(38)30(4)57)42(59)50-36(43(60)52-37(26-56)44(61)53-40(41(47)58)29(3)68-69(63,64)65)23-31-24-48-27-54(31)19-10-5-6-11-21-66-49-25-33-34(46)16-12-18-39(33)67-32-14-8-7-9-15-32/h7-9,12,14-16,18,24-25,27-29,35-38,40,56H,5-6,10-11,13,17,19-23,26H2,1-4H3,(H2,47,58)(H,50,59)(H,51,62)(H,52,60)(H,53,61)(H2,63,64,65)/b49-25-/t29-,35+,36+,37+,38+,40+/m1/s1 ACUJSWPHFSMCON-KITDGBJQSA-N 50194936 CHEMBL3916818 Serine/threonine-protein kinase PLK1 Homo sapiens 670 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194936&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134143573 375977041 CHEMBL3916818 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521348 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 UIYQCJDQBRUFEV-FALOATQWSA-N 50403017 CHEMBL2207846 Serine/threonine-protein kinase PLK1 Homo sapiens >300000 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49873221 163352041 CHEMBL2207846 ZINC95564030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521349 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C\c1cnc(s1)N(C)Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C44H66N11O12PS/c1-28(2)20-34(50-43(62)37-16-13-18-55(37)30(4)57)40(59)49-35(41(60)51-36(26-56)42(61)52-38(39(45)58)29(3)67-68(63,64)65)21-32-22-46-27-54(32)17-11-6-7-12-19-66-48-24-33-23-47-44(69-33)53(5)25-31-14-9-8-10-15-31/h8-10,14-15,22-24,27-29,34-38,56H,6-7,11-13,16-21,25-26H2,1-5H3,(H2,45,58)(H,49,59)(H,50,62)(H,51,60)(H,52,61)(H2,63,64,65)/b48-24+/t29-,34+,35+,36+,37+,38+/m1/s1 KSYUJQDWOGQQIP-NXWKYJJNSA-N 50194937 CHEMBL3944369 Serine/threonine-protein kinase PLK1 Homo sapiens 133 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194937&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134146143 375977042 CHEMBL3944369 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521350 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C/c1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C45H63FN9O13P/c1-28(2)22-35(51-45(62)38-17-13-20-55(38)30(4)57)42(59)50-36(43(60)52-37(26-56)44(61)53-40(41(47)58)29(3)68-69(63,64)65)23-31-24-48-27-54(31)19-10-5-6-11-21-66-49-25-33-34(46)16-12-18-39(33)67-32-14-8-7-9-15-32/h7-9,12,14-16,18,24-25,27-29,35-38,40,56H,5-6,10-11,13,17,19-23,26H2,1-4H3,(H2,47,58)(H,50,59)(H,51,62)(H,52,60)(H,53,61)(H2,63,64,65)/b49-25-/t29-,35+,36+,37+,38+,40+/m1/s1 ACUJSWPHFSMCON-KITDGBJQSA-N 50194936 CHEMBL3916818 Serine/threonine-protein kinase PLK1 Homo sapiens 91 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194936&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134143573 375977041 CHEMBL3916818 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521351 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCO\N=C\c1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C38H58N9O12P/c1-24(2)18-29(43-38(54)32-14-11-16-47(32)26(4)49)35(51)42-30(36(52)44-31(22-48)37(53)45-33(34(39)50)25(3)59-60(55,56)57)19-28-21-40-23-46(28)15-9-6-10-17-58-41-20-27-12-7-5-8-13-27/h5,7-8,12-13,20-21,23-25,29-33,48H,6,9-11,14-19,22H2,1-4H3,(H2,39,50)(H,42,51)(H,43,54)(H,44,52)(H,45,53)(H2,55,56,57)/b41-20+/t25-,29+,30+,31+,32+,33+/m1/s1 NDZJFAYZPBTTDL-IQJHCYRHSA-N 50194938 CHEMBL3940088 Serine/threonine-protein kinase PLK1 Homo sapiens 2380 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194938&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134148859 375977043 CHEMBL3940088 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521352 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 UIYQCJDQBRUFEV-FALOATQWSA-N 50403017 CHEMBL2207846 Serine/threonine-protein kinase PLK1 Homo sapiens 21500 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49873221 163352041 CHEMBL2207846 ZINC95564030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521353 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCO\N=C\c1csc(n1)N(C(C)=O)c1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C43H62N11O13PS/c1-26(2)19-33(49-42(62)36-15-12-17-53(36)28(4)56)39(59)48-34(40(60)50-35(23-55)41(61)51-37(38(44)58)27(3)67-68(63,64)65)20-32-22-45-25-52(32)16-10-7-11-18-66-46-21-30-24-69-43(47-30)54(29(5)57)31-13-8-6-9-14-31/h6,8-9,13-14,21-22,24-27,33-37,55H,7,10-12,15-20,23H2,1-5H3,(H2,44,58)(H,48,59)(H,49,62)(H,50,60)(H,51,61)(H2,63,64,65)/b46-21+/t27-,33+,34+,35+,36+,37+/m1/s1 SSGQBUPRSFPFIB-GHOWNLRVSA-N 50194939 CHEMBL3916430 Serine/threonine-protein kinase PLK1 Homo sapiens 119 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194939&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134143656 375977044 CHEMBL3916430 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521354 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C46H67N8O12P/c1-30(2)25-36(50-46(61)39-21-16-24-54(39)32(4)56)43(58)49-37(44(59)51-38(28-55)45(60)52-41(42(47)57)31(3)66-67(62,63)64)26-34-27-48-29-53(34)23-15-8-6-5-7-10-17-33-18-13-14-22-40(33)65-35-19-11-9-12-20-35/h9,11-14,18-20,22,27,29-31,36-39,41,55H,5-8,10,15-17,21,23-26,28H2,1-4H3,(H2,47,57)(H,49,58)(H,50,61)(H,51,59)(H,52,60)(H2,62,63,64)/t31-,36+,37+,38+,39+,41+/m1/s1 GXROUISBNDMFKO-WTZADEQLSA-N 50194940 CHEMBL3985321 Serine/threonine-protein kinase PLK1 Homo sapiens 52 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194940&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134157971 375977045 CHEMBL3985321 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521355 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCO\N=C\c1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C39H60N9O12P/c1-25(2)19-30(44-39(55)33-15-12-17-48(33)27(4)50)36(52)43-31(37(53)45-32(23-49)38(54)46-34(35(40)51)26(3)60-61(56,57)58)20-29-22-41-24-47(29)16-10-5-6-11-18-59-42-21-28-13-8-7-9-14-28/h7-9,13-14,21-22,24-26,30-34,49H,5-6,10-12,15-20,23H2,1-4H3,(H2,40,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/b42-21+/t26-,30+,31+,32+,33+,34+/m1/s1 KJQNIUMZTBTNPM-TYYMDPTCSA-N 50194932 CHEMBL3921057 Serine/threonine-protein kinase PLK1 Homo sapiens 5050 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134139987 375977038 CHEMBL3921057 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521356 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCO\N=C\c1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C38H58N9O12P/c1-24(2)18-29(43-38(54)32-14-11-16-47(32)26(4)49)35(51)42-30(36(52)44-31(22-48)37(53)45-33(34(39)50)25(3)59-60(55,56)57)19-28-21-40-23-46(28)15-9-6-10-17-58-41-20-27-12-7-5-8-13-27/h5,7-8,12-13,20-21,23-25,29-33,48H,6,9-11,14-19,22H2,1-4H3,(H2,39,50)(H,42,51)(H,43,54)(H,44,52)(H,45,53)(H2,55,56,57)/b41-20+/t25-,29+,30+,31+,32+,33+/m1/s1 NDZJFAYZPBTTDL-IQJHCYRHSA-N 50194938 CHEMBL3940088 Serine/threonine-protein kinase PLK1 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194938&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134148859 375977043 CHEMBL3940088 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521357 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCCc1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C47H68FN8O12P/c1-30(2)25-37(52-47(63)40-21-16-24-56(40)32(4)58)44(60)51-38(45(61)53-39(28-57)46(62)54-42(43(49)59)31(3)68-69(64,65)66)26-33-27-50-29-55(33)23-14-9-7-5-6-8-13-19-35-36(48)20-15-22-41(35)67-34-17-11-10-12-18-34/h10-12,15,17-18,20,22,27,29-31,37-40,42,57H,5-9,13-14,16,19,21,23-26,28H2,1-4H3,(H2,49,59)(H,51,60)(H,52,63)(H,53,61)(H,54,62)(H2,64,65,66)/t31-,37+,38+,39+,40+,42+/m1/s1 ZPKPKCOLWJOVJV-ZTHSRUGTSA-N 50194941 CHEMBL3977234 Serine/threonine-protein kinase PLK1 Homo sapiens 139 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194941&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134151495 375977046 CHEMBL3977234 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521358 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1-c1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C46H67N8O11P/c1-30(2)25-37(50-46(61)40-22-16-24-54(40)32(4)56)43(58)49-38(44(59)51-39(28-55)45(60)52-41(42(47)57)31(3)65-66(62,63)64)26-35-27-48-29-53(35)23-15-8-6-5-7-10-17-34-20-13-14-21-36(34)33-18-11-9-12-19-33/h9,11-14,18-21,27,29-31,37-41,55H,5-8,10,15-17,22-26,28H2,1-4H3,(H2,47,57)(H,49,58)(H,50,61)(H,51,59)(H,52,60)(H2,62,63,64)/t31-,37+,38+,39+,40+,41+/m1/s1 VWTMBJNORZHGHE-ICMBXEKGSA-N 50194942 CHEMBL3954114 Serine/threonine-protein kinase PLK1 Homo sapiens 43 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194942&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134145100 375977047 CHEMBL3954114 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521359 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 121 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521360 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521361 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCO\N=C\c1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C44H61FN9O13P/c1-27(2)21-34(50-44(61)37-16-12-19-54(37)29(4)56)41(58)49-35(42(59)51-36(25-55)43(60)52-39(40(46)57)28(3)67-68(62,63)64)22-30-23-47-26-53(30)18-9-6-10-20-65-48-24-32-33(45)15-11-17-38(32)66-31-13-7-5-8-14-31/h5,7-8,11,13-15,17,23-24,26-28,34-37,39,55H,6,9-10,12,16,18-22,25H2,1-4H3,(H2,46,57)(H,49,58)(H,50,61)(H,51,59)(H,52,60)(H2,62,63,64)/b48-24+/t28-,34+,35+,36+,37+,39+/m1/s1 QINOMHBLNDVOTP-GXQKTUKWSA-N 50194931 CHEMBL3944723 Serine/threonine-protein kinase PLK1 Homo sapiens 163 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134146150 104077103 CHEMBL3944723 ZINC03942872 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521362 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCO\N=C\c1cnc(s1)N(C)Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C43H64N11O12PS/c1-27(2)19-33(49-42(61)36-15-12-17-54(36)29(4)56)39(58)48-34(40(59)50-35(25-55)41(60)51-37(38(44)57)28(3)66-67(62,63)64)20-31-21-45-26-53(31)16-10-7-11-18-65-47-23-32-22-46-43(68-32)52(5)24-30-13-8-6-9-14-30/h6,8-9,13-14,21-23,26-28,33-37,55H,7,10-12,15-20,24-25H2,1-5H3,(H2,44,57)(H,48,58)(H,49,61)(H,50,59)(H,51,60)(H2,62,63,64)/b47-23+/t28-,33+,34+,35+,36+,37+/m1/s1 UPWFDMAFUHNQNM-XIKJUOIESA-N 50194943 CHEMBL3925420 Serine/threonine-protein kinase PLK1 Homo sapiens 244 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194943&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134140795 375977048 CHEMBL3925420 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521363 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1OCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C47H69N8O12P/c1-31(2)25-37(51-47(62)40-21-16-24-55(40)33(4)57)44(59)50-38(45(60)52-39(28-56)46(61)53-42(43(48)58)32(3)67-68(63,64)65)26-36-27-49-30-54(36)23-15-8-6-5-7-12-19-35-20-13-14-22-41(35)66-29-34-17-10-9-11-18-34/h9-11,13-14,17-18,20,22,27,30-32,37-40,42,56H,5-8,12,15-16,19,21,23-26,28-29H2,1-4H3,(H2,48,58)(H,50,59)(H,51,62)(H,52,60)(H,53,61)(H2,63,64,65)/t32-,37+,38+,39+,40+,42+/m1/s1 LYLANQFTXJWIGY-SWLZGSTDSA-N 50194944 CHEMBL3935387 Serine/threonine-protein kinase PLK1 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194944&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134148478 375977049 CHEMBL3935387 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50521364 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCc1ccccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C44H63N8O12P/c1-28(2)23-34(48-44(59)37-19-14-22-52(37)30(4)54)41(56)47-35(42(57)49-36(26-53)43(58)50-39(40(45)55)29(3)64-65(60,61)62)24-32-25-46-27-51(32)21-13-6-5-8-15-31-16-11-12-20-38(31)63-33-17-9-7-10-18-33/h7,9-12,16-18,20,25,27-29,34-37,39,53H,5-6,8,13-15,19,21-24,26H2,1-4H3,(H2,45,55)(H,47,56)(H,48,59)(H,49,57)(H,50,58)(H2,60,61,62)/t29-,34+,35+,36+,37+,39+/m1/s1 VBUBVQOQXYMYMF-KJHGNAGRSA-N 50194945 CHEMBL3965583 Serine/threonine-protein kinase PLK1 Homo sapiens 139 ChEMBL 10.1016/j.bmcl.2016.08.098 10.7270/Q2G44S7H 27624074 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194945&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134150093 375977050 CHEMBL3965583 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50520208 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 0.870000 ChEMBL 10.1021/acs.jmedchem.6b00472 10.7270/Q29G5PR8 27299736 Talele, TT St. John's University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51014793 COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3 QLDFAHVPALXKAU-UHFFFAOYSA-N 50415616 CHEMBL1087421 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415616&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44138048 163364640 CHEMBL1087421 ZINC49054159 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51014815 COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3 FRZUSJCWOONEQS-UHFFFAOYSA-N 50415620 CHEMBL1088633 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415620&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44138049 163364644 CHEMBL1088633 ZINC49067053 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069228 CC[C@H]1N(C2COC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C21H21FN6O2/c1-3-16-20(29)26(2)17-10-24-21(25-19(17)28(16)15-11-30-12-15)27-9-8-23-18(27)13-4-6-14(22)7-5-13/h4-10,15-16H,3,11-12H2,1-2H3/t16-/m1/s1 UFRMEDNDGZCHLF-MRXNPFEDSA-N 50436722 CHEMBL2401970 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436722&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405741 175449039 CHEMBL2401970 ZINC96272642 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069229 CC(C)N1c2nc(ncc2N(C)C(=O)C1(C)C)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C21H23FN6O/c1-13(2)28-18-16(26(5)19(29)21(28,3)4)12-24-20(25-18)27-11-10-23-17(27)14-6-8-15(22)9-7-14/h6-13H,1-5H3 RCTLMZOWMCIZPV-UHFFFAOYSA-N 50436723 CHEMBL2401961 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436723&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405755 175449040 CHEMBL2401961 ZINC96272643 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069230 CC[C@H]1N(c2ccnn2C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C22H21FN8O/c1-4-16-21(32)28(2)17-13-25-22(27-20(17)31(16)18-9-10-26-29(18)3)30-12-11-24-19(30)14-5-7-15(23)8-6-14/h5-13,16H,4H2,1-3H3/t16-/m1/s1 RJBBMLHRKBGRBY-MRXNPFEDSA-N 50436724 CHEMBL2402082 Serine/threonine-protein kinase PLK1 Homo sapiens 28800 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436724&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602874 175449041 CHEMBL2402082 ZINC96272644 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069231 CC(C)N1c2nc(ncc2N(C)C(=O)C11CCC1)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C22H23FN6O/c1-14(2)29-19-17(27(3)20(30)22(29)9-4-10-22)13-25-21(26-19)28-12-11-24-18(28)15-5-7-16(23)8-6-15/h5-8,11-14H,4,9-10H2,1-3H3 ZQQFEJKKQWPBQA-UHFFFAOYSA-N 50436725 CHEMBL2401960 Serine/threonine-protein kinase PLK1 Homo sapiens 25300 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436725&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405566 175449042 CHEMBL2401960 ZINC96272645 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069232 CC[C@H]1N(C2CC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C22H21F3N6O/c1-3-16-20(32)29(2)17-12-27-21(28-19(17)31(16)15-10-22(24,25)11-15)30-9-8-26-18(30)13-4-6-14(23)7-5-13/h4-9,12,15-16H,3,10-11H2,1-2H3/t16-/m1/s1 WKIWJYRJQNQEGF-MRXNPFEDSA-N 50436726 CHEMBL2401969 Serine/threonine-protein kinase PLK1 Homo sapiens 9390 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436726&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405910 175449043 CHEMBL2401969 ZINC96272646 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069233 CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C21H19FN8O/c1-3-16-20(31)28(2)17-12-24-21(27-19(17)30(16)15-10-25-26-11-15)29-9-8-23-18(29)13-4-6-14(22)7-5-13/h4-12,16H,3H2,1-2H3,(H,25,26)/t16-/m1/s1 DDHRKINLNCDPNG-MRXNPFEDSA-N 50436727 CHEMBL2402078 Serine/threonine-protein kinase PLK1 Homo sapiens 8670 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436727&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405673 175449044 CHEMBL2402078 ZINC96272647 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069234 CC[C@H]1N(c2cncnc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 InChI=1S/C22H20N8O/c1-3-17-21(31)28(2)18-13-26-22(27-20(18)30(17)16-11-23-14-24-12-16)29-10-9-25-19(29)15-7-5-4-6-8-15/h4-14,17H,3H2,1-2H3/t17-/m1/s1 HKSMOPLPIGGMTK-QGZVFWFLSA-N 50436728 CHEMBL2402077 Serine/threonine-protein kinase PLK1 Homo sapiens 7760 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436728&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602829 175449045 CHEMBL2402077 ZINC96272648 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069235 CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C22H23FN6O2/c1-3-17-21(30)27(2)18-12-25-22(26-20(18)29(17)16-8-11-31-13-16)28-10-9-24-19(28)14-4-6-15(23)7-5-14/h4-7,9-10,12,16-17H,3,8,11,13H2,1-2H3/t16-,17+/m0/s1 HXPKCEXQOBXOIS-DLBZAZTESA-N 50436729 CHEMBL2401973 Serine/threonine-protein kinase PLK1 Homo sapiens 7530 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436729&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602780 175449046 CHEMBL2401973 ZINC96272649 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069236 CCC1(C)N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C22H22F4N6O/c1-4-21(2)19(33)30(3)16-13-28-20(29-18(16)32(21)11-9-22(24,25)26)31-12-10-27-17(31)14-5-7-15(23)8-6-14/h5-8,10,12-13H,4,9,11H2,1-3H3 RJCQITTXWSWFFO-UHFFFAOYSA-N 50436730 CHEMBL2401959 Serine/threonine-protein kinase PLK1 Homo sapiens 7160 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436730&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58415665 175449047 CHEMBL2401959 ZINC96272651 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069237 CCC1N(c2ccc(cc2)C#N)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C25H20FN7O/c1-3-20-24(34)31(2)21-15-29-25(30-23(21)33(20)19-10-4-16(14-27)5-11-19)32-13-12-28-22(32)17-6-8-18(26)9-7-17/h4-13,15,20H,3H2,1-2H3 SQHOHRAPERDRPS-UHFFFAOYSA-N 50436731 CHEMBL2402076 Serine/threonine-protein kinase PLK1 Homo sapiens 3760 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436731&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405593 175449048 CHEMBL2402076 ZINC96272653 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069238 CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C21H20F4N6O/c1-3-15-19(32)29(2)16-12-27-20(28-18(16)30(15)10-8-21(23,24)25)31-11-9-26-17(31)13-4-6-14(22)7-5-13/h4-7,9,11-12,15H,3,8,10H2,1-2H3/t15-/m1/s1 XDUIHJCDFMNCIS-OAHLLOKOSA-N 50436732 CHEMBL2401967 Serine/threonine-protein kinase PLK1 Homo sapiens 3550 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436732&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405817 175449049 CHEMBL2401967 ZINC96272654 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069239 CN1C(=O)C(CC(F)(F)F)N(CCC(F)(F)F)c2nc(ncc12)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C21H17F7N6O/c1-32-15-11-30-19(34-9-7-29-16(34)12-2-4-13(22)5-3-12)31-17(15)33(8-6-20(23,24)25)14(18(32)35)10-21(26,27)28/h2-5,7,9,11,14H,6,8,10H2,1H3 YUWWKWVVBFASIG-UHFFFAOYSA-N 50436733 CHEMBL2401958 Serine/threonine-protein kinase PLK1 Homo sapiens 3480 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436733&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602875 175449050 CHEMBL2401958 ZINC96272656 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069240 CCC1N(c2ccn[nH]2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C21H19FN8O/c1-3-15-20(31)28(2)16-12-24-21(26-19(16)30(15)17-8-9-25-27-17)29-11-10-23-18(29)13-4-6-14(22)7-5-13/h4-12,15H,3H2,1-2H3,(H,25,27) QCJIMVKECGDPPA-UHFFFAOYSA-N 50436734 CHEMBL2402079 Serine/threonine-protein kinase PLK1 Homo sapiens 3420 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436734&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405732 175449051 CHEMBL2402079 ZINC96272658 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069241 CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C22H21FN8O/c1-4-17-21(32)29(3)18-12-25-22(27-20(18)31(17)16-11-26-28(2)13-16)30-10-9-24-19(30)14-5-7-15(23)8-6-14/h5-13,17H,4H2,1-3H3/t17-/m1/s1 RVEBOFKFYDCQPT-QGZVFWFLSA-N 50436735 CHEMBL2402080 Serine/threonine-protein kinase PLK1 Homo sapiens 3290 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436735&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53261787 175449052 CHEMBL2402080 ZINC96272659 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069242 CC[C@H]1N(c2cn[nH]c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 InChI=1S/C18H17N9OS/c1-3-12-18(28)26(2)13-9-20-15(24-16(13)27(12)10-6-21-22-7-10)11-8-23-25-14(11)17-19-4-5-29-17/h4-9,12H,3H2,1-2H3,(H,21,22)(H,23,25)/t12-/m1/s1 CPDRDZZZFNTJCE-GFCCVEGCSA-N 50436736 CHEMBL2402085 Serine/threonine-protein kinase PLK1 Homo sapiens 3030 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436736&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405948 175449053 CHEMBL2402085 ZINC96272660 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069243 CCC1N(c2ccccc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 InChI=1S/C24H22N6O/c1-3-19-23(31)28(2)20-16-26-24(27-22(20)30(19)18-12-8-5-9-13-18)29-15-14-25-21(29)17-10-6-4-7-11-17/h4-16,19H,3H2,1-2H3 ZJJBLPXVAOPPAR-UHFFFAOYSA-N 50436737 CHEMBL2401974 Serine/threonine-protein kinase PLK1 Homo sapiens 2830 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436737&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602828 175449054 CHEMBL2401974 ZINC96272662 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069244 CCC1N(c2ccc(F)cc2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C24H20F2N6O/c1-3-19-23(33)30(2)20-14-28-24(29-22(20)32(19)18-10-8-17(26)9-11-18)31-13-12-27-21(31)15-4-6-16(25)7-5-15/h4-14,19H,3H2,1-2H3 QWAKOUIKNVQHES-UHFFFAOYSA-N 50436738 CHEMBL2401975 Serine/threonine-protein kinase PLK1 Homo sapiens 2340 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436738&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405571 175449055 CHEMBL2401975 ZINC96272664 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069245 CCC1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1ccccn1 InChI=1S/C21H21N9O/c1-4-16-21(31)29(3)17-11-23-19(26-20(17)30(16)13-9-25-28(2)12-13)14-10-24-27-18(14)15-7-5-6-8-22-15/h5-12,16H,4H2,1-3H3,(H,24,27) LBJBUWVRDHIUEP-UHFFFAOYSA-N 50436739 CHEMBL2401957 Serine/threonine-protein kinase PLK1 Homo sapiens 1820 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436739&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405634 175449056 CHEMBL2401957 ZINC96272666 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069246 CCC1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 InChI=1S/C19H19N9OS/c1-4-13-19(29)27(3)14-9-21-16(12-8-22-25-15(12)18-20-5-6-30-18)24-17(14)28(13)11-7-23-26(2)10-11/h5-10,13H,4H2,1-3H3,(H,22,25) XNXPWGGHJWESTI-UHFFFAOYSA-N 50436740 CHEMBL2402086 Serine/threonine-protein kinase PLK1 Homo sapiens 1820 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436740&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405504 175449057 CHEMBL2402086 ZINC96272668 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069247 CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 InChI=1S/C19H21N7O2S/c1-3-13-19(27)25(2)14-9-21-16(23-17(14)26(13)11-4-6-28-10-11)12-8-22-24-15(12)18-20-5-7-29-18/h5,7-9,11,13H,3-4,6,10H2,1-2H3,(H,22,24)/t11-,13+/m0/s1 PBCXNVUBDXBJNG-WCQYABFASA-N 50436741 CHEMBL2402084 Serine/threonine-protein kinase PLK1 Homo sapiens 1410 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436741&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 73353563 175449058 CHEMBL2402084 ZINC96272669 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069248 CC[C@H]1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C22H21FN8O/c1-4-16-21(32)29(3)17-13-25-22(26-20(17)31(16)18-9-11-28(2)27-18)30-12-10-24-19(30)14-5-7-15(23)8-6-14/h5-13,16H,4H2,1-3H3/t16-/m1/s1 JMVCDNFYMJCUDW-MRXNPFEDSA-N 50436742 CHEMBL2402081 Serine/threonine-protein kinase PLK1 Homo sapiens 1350 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436742&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53261846 175449059 CHEMBL2402081 ZINC96272670 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069249 CC[C@H]1N(c2cnn(C)c2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1ccc(F)cc1F InChI=1S/C22H20F2N8O/c1-4-17-22(33)31(3)18-10-25-20(28-21(18)32(17)13-8-27-30(2)11-13)15-9-26-29-19(15)14-6-5-12(23)7-16(14)24/h5-11,17H,4H2,1-3H3,(H,26,29)/t17-/m1/s1 WFYIXLNYITUPPQ-QGZVFWFLSA-N 50436743 CHEMBL2401956 Serine/threonine-protein kinase PLK1 Homo sapiens 1260 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436743&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53261848 175449060 CHEMBL2401956 ZINC96272671 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069250 CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 InChI=1S/C21H24N6O/c1-5-16-20(28)25(4)17-13-23-21(24-19(17)27(16)14(2)3)26-12-11-22-18(26)15-9-7-6-8-10-15/h6-14,16H,5H2,1-4H3/t16-/m1/s1 GNFVJCMQLYMYRH-MRXNPFEDSA-N 50436744 CHEMBL2401965 Serine/threonine-protein kinase PLK1 Homo sapiens 870 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436744&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405292 175449061 CHEMBL2401965 ZINC96272672 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069251 CC[C@H]1N(C(C)C)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 InChI=1S/C18H21N7OS/c1-5-12-18(26)24(4)13-9-20-15(22-16(13)25(12)10(2)3)11-8-21-23-14(11)17-19-6-7-27-17/h6-10,12H,5H2,1-4H3,(H,21,23)/t12-/m1/s1 PMMISILPBLQWSZ-GFCCVEGCSA-N 50436721 CHEMBL2401964 Serine/threonine-protein kinase PLK1 Homo sapiens 770 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436721&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405636 175449038 CHEMBL2401964 ZINC96272641 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069252 CC[C@H]1N([C@@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 InChI=1S/C22H24N6O2/c1-3-17-21(29)26(2)18-13-24-22(25-20(18)28(17)16-9-12-30-14-16)27-11-10-23-19(27)15-7-5-4-6-8-15/h4-8,10-11,13,16-17H,3,9,12,14H2,1-2H3/t16-,17-/m1/s1 UMJFDLYATACWKW-IAGOWNOFSA-N 50436745 CHEMBL2401972 Serine/threonine-protein kinase PLK1 Homo sapiens 480 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436745&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602779 175449062 CHEMBL2401972 ZINC96272673 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069253 CC[C@H]1N([C@H]2CCOC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 InChI=1S/C22H24N6O2/c1-3-17-21(29)26(2)18-13-24-22(25-20(18)28(17)16-9-12-30-14-16)27-11-10-23-19(27)15-7-5-4-6-8-15/h4-8,10-11,13,16-17H,3,9,12,14H2,1-2H3/t16-,17+/m0/s1 UMJFDLYATACWKW-DLBZAZTESA-N 50436746 CHEMBL2401971 Serine/threonine-protein kinase PLK1 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436746&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602778 175449063 CHEMBL2401971 ZINC96272674 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069254 CCC1N(C2CCC(F)(F)C2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccc(F)cc1 InChI=1S/C23H23F3N6O/c1-3-17-21(33)30(2)18-13-28-22(29-20(18)32(17)16-8-9-23(25,26)12-16)31-11-10-27-19(31)14-4-6-15(24)7-5-14/h4-7,10-11,13,16-17H,3,8-9,12H2,1-2H3 RHIJMDNVEPLDED-UHFFFAOYSA-N 50436747 CHEMBL2401968 Serine/threonine-protein kinase PLK1 Homo sapiens 320 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436747&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602777 175449064 CHEMBL2401968 ZINC96272676 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069255 CC[C@H]1N(C2CCOCC2)c2nc(ncc2N(C)C1=O)-c1c[nH]nc1-c1nccs1 InChI=1S/C20H23N7O2S/c1-3-14-20(28)26(2)15-11-22-17(13-10-23-25-16(13)19-21-6-9-30-19)24-18(15)27(14)12-4-7-29-8-5-12/h6,9-12,14H,3-5,7-8H2,1-2H3,(H,23,25)/t14-/m1/s1 NILXCNICWMPUMM-CQSZACIVSA-N 50436748 CHEMBL2402083 Serine/threonine-protein kinase PLK1 Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436748&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405467 175449065 CHEMBL2402083 ZINC96272677 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069256 CC[C@H]1N(CCC(F)(F)F)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 InChI=1S/C21H21F3N6O/c1-3-15-19(31)28(2)16-13-26-20(27-18(16)29(15)11-9-21(22,23)24)30-12-10-25-17(30)14-7-5-4-6-8-14/h4-8,10,12-13,15H,3,9,11H2,1-2H3/t15-/m1/s1 KOKNYBBQIVDZCK-OAHLLOKOSA-N 50436749 CHEMBL2401966 Serine/threonine-protein kinase PLK1 Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436749&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405323 175449066 CHEMBL2401966 ZINC96272678 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51069257 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccnc1-c1ccccc1 InChI=1S/C23H26N6O/c1-3-18-22(30)27(2)19-15-25-23(26-21(19)29(18)17-11-7-8-12-17)28-14-13-24-20(28)16-9-5-4-6-10-16/h4-6,9-10,13-15,17-18H,3,7-8,11-12H2,1-2H3/t18-/m1/s1 JMDRAMDTWLAOHD-GOSISDBHSA-N 50436720 CHEMBL2401963 Serine/threonine-protein kinase PLK1 Homo sapiens 8.0 ChEMBL 10.1016/j.bmcl.2013.02.065 10.7270/Q28G8N4M 23522834 Bowers, S; Truong, AP; Ye, M; Aubele, DL; Sealy, JM; Neitz, RJ; Hom, RK; Chan, W; Dappen, MS; Galemmo, RA; Konradi, AW; Sham, HL; Zhu, YL; Beroza, P; Tonn, G; Zhang, H; Hoffman, J; Motter, R; Fauss, D; Tanaka, P; Bova, MP; Ren, Z; Tam, D; Ruslim, L; Baker, J; Pandya, D; Diep, L; Fitzgerald, K; Artis, DR; Anderson, JP; Bergeron, M Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436720&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1C7 4I6F 58405631 175449037 CHEMBL2401963 ZINC95921024 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071474 OC(=O)c1ccc(\C=C\c2n[nH]c3cc(\C=C4\C(=O)Nc5ccccc45)ccc23)cc1 InChI=1S/C25H17N3O3/c29-24-20(18-3-1-2-4-21(18)26-24)13-16-7-11-19-22(27-28-23(19)14-16)12-8-15-5-9-17(10-6-15)25(30)31/h1-14H,(H,26,29)(H,27,28)(H,30,31)/b12-8+,20-13+ FOMWYZMFUGYYLZ-ADFPNGHDSA-N 50437840 CHEMBL2407744 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437840&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189730 175450157 CHEMBL2407744 ZINC96273693 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071475 COc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5ccc(nc5)N5CCN(C)CC5)n[nH]c4c3)c2c1 InChI=1S/C29H28N6O2/c1-34-11-13-35(14-12-34)28-10-5-19(18-30-28)4-8-26-22-7-3-20(16-27(22)33-32-26)15-24-23-17-21(37-2)6-9-25(23)31-29(24)36/h3-10,15-18H,11-14H2,1-2H3,(H,31,36)(H,32,33)/b8-4+,24-15+ GBUDRABUNBYJKG-WWAWLHJKSA-N 50437841 CHEMBL2407900 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437841&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189785 175450158 CHEMBL2407900 ZINC68250882 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071476 CN1CCN(CC1)c1ccc(\C=C\c2n[nH]c3cc(\C=C4\C(=O)Nc5ccccc45)ccc23)cn1 InChI=1S/C28H26N6O/c1-33-12-14-34(15-13-33)27-11-8-19(18-29-27)7-10-25-22-9-6-20(17-26(22)32-31-25)16-23-21-4-2-3-5-24(21)30-28(23)35/h2-11,16-18H,12-15H2,1H3,(H,30,35)(H,31,32)/b10-7+,23-16+ FQWPBCFJZAKNEQ-CBVNATGFSA-N 50437842 CHEMBL2407899 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437842&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189710 175450159 CHEMBL2407899 ZINC96273694 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071477 COc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5ccc(CN(C)C)cc5)n[nH]c4c3)c2c1 InChI=1S/C28H26N4O2/c1-32(2)17-19-6-4-18(5-7-19)9-12-26-22-11-8-20(15-27(22)31-30-26)14-24-23-16-21(34-3)10-13-25(23)29-28(24)33/h4-16H,17H2,1-3H3,(H,29,33)(H,30,31)/b12-9+,24-14+ UPAQROHCJDLJNE-JBFZHCRBSA-N 50437843 CHEMBL2407898 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437843&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189752 175450160 CHEMBL2407898 ZINC96273695 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071478 CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(\C=C4\C(=O)Nc5ccccc45)ccc23)cc1 InChI=1S/C27H24N4O/c1-31(2)17-19-9-7-18(8-10-19)12-14-25-22-13-11-20(16-26(22)30-29-25)15-23-21-5-3-4-6-24(21)28-27(23)32/h3-16H,17H2,1-2H3,(H,28,32)(H,29,30)/b14-12+,23-15+ HCLJFCCORISDCX-NLUXTTPZSA-N 50437837 CHEMBL2407897 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189807 175450154 CHEMBL2407897 ZINC96273690 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071479 O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccccc3)n[nH]c2c1 InChI=1S/C24H17N3O/c28-24-20(18-8-4-5-9-21(18)25-24)14-17-10-12-19-22(26-27-23(19)15-17)13-11-16-6-2-1-3-7-16/h1-15H,(H,25,28)(H,26,27)/b13-11+,20-14+ YJKHNFBXHIHRMJ-WRMRRPGHSA-N 50437844 CHEMBL2407896 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437844&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189825 175450161 CHEMBL2407896 ZINC96273696 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071480 Oc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5ccncc5)n[nH]c4c3)c2c1 InChI=1S/C23H16N4O2/c28-16-3-6-20-18(13-16)19(23(29)25-20)11-15-1-4-17-21(26-27-22(17)12-15)5-2-14-7-9-24-10-8-14/h1-13,28H,(H,25,29)(H,26,27)/b5-2+,19-11+ YKIVNICLNFURQO-NHSDSWEZSA-N 50437845 CHEMBL2407895 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437845&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71819093 175450162 CHEMBL2407895 ZINC96273697 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071481 COc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5ccncc5)n[nH]c4c3)c2c1 InChI=1S/C24H18N4O2/c1-30-17-4-7-21-19(14-17)20(24(29)26-21)12-16-2-5-18-22(27-28-23(18)13-16)6-3-15-8-10-25-11-9-15/h2-14H,1H3,(H,26,29)(H,27,28)/b6-3+,20-12+ DOLNBRDFBGDLQN-VGKQJACHSA-N 50437846 CHEMBL2407894 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437846&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189736 175450163 CHEMBL2407894 ZINC68250887 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071482 Cc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5ccncc5)n[nH]c4c3)c2c1 InChI=1S/C24H18N4O/c1-15-2-6-21-19(12-15)20(24(29)26-21)13-17-3-5-18-22(27-28-23(18)14-17)7-4-16-8-10-25-11-9-16/h2-14H,1H3,(H,26,29)(H,27,28)/b7-4+,20-13+ QDBKDMHYYVPUJY-UJPRRALESA-N 50437847 CHEMBL2407893 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437847&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189680 175450164 CHEMBL2407893 ZINC96273698 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071483 Clc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5ccncc5)n[nH]c4c3)c2c1 InChI=1S/C23H15ClN4O/c24-16-3-6-20-18(13-16)19(23(29)26-20)11-15-1-4-17-21(27-28-22(17)12-15)5-2-14-7-9-25-10-8-14/h1-13H,(H,26,29)(H,27,28)/b5-2+,19-11+ VFYXAFQACZHFRL-NHSDSWEZSA-N 50437848 CHEMBL2407750 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437848&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189748 175450165 CHEMBL2407750 ZINC96273699 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071485 COc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5cccnc5)n[nH]c4c3)c2c1 InChI=1S/C24H18N4O2/c1-30-17-6-9-21-19(13-17)20(24(29)26-21)11-16-4-7-18-22(27-28-23(18)12-16)8-5-15-3-2-10-25-14-15/h2-14H,1H3,(H,26,29)(H,27,28)/b8-5+,20-11+ ZGEQGZFSJZJWAR-JNJFRLMHSA-N 50437849 CHEMBL2407748 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437849&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189773 175450166 CHEMBL2407748 ZINC96273700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071486 CCc1ccc2NC(=O)\C(=C\c3ccc4c(\C=C\c5cccnc5)n[nH]c4c3)c2c1 InChI=1S/C25H20N4O/c1-2-16-6-9-22-20(12-16)21(25(30)27-22)13-18-5-8-19-23(28-29-24(19)14-18)10-7-17-4-3-11-26-15-17/h3-15H,2H2,1H3,(H,27,30)(H,28,29)/b10-7+,21-13+ OLRQMHGOBAYXHZ-FPQBULDBSA-N 50437850 CHEMBL2407747 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437850&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71818953 175450167 CHEMBL2407747 ZINC96273701 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071487 O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3cccnc3)n[nH]c2c1 InChI=1S/C23H16N4O/c28-23-19(17-5-1-2-6-20(17)25-23)12-16-7-9-18-21(26-27-22(18)13-16)10-8-15-4-3-11-24-14-15/h1-14H,(H,25,28)(H,26,27)/b10-8+,19-12+ CPIOXRCBBSICIO-SLUIUKIVSA-N 50437851 CHEMBL2407746 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437851&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189781 175450168 CHEMBL2407746 ZINC96273702 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071488 O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C23H16N4O/c28-23-19(17-6-1-2-7-20(17)25-23)13-15-8-10-18-21(26-27-22(18)14-15)11-9-16-5-3-4-12-24-16/h1-14H,(H,25,28)(H,26,27)/b11-9+,19-13+ BPGUPPRJBLLMOX-JDCCHMEXSA-N 50437852 CHEMBL2407745 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437852&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189743 175450169 CHEMBL2407745 ZINC96273703 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071489 CC(=O)Nc1ccc2\C(=C/c3ccc4cn[nH]c4c3)C(=O)Nc2c1 InChI=1S/C18H14N4O2/c1-10(23)20-13-4-5-14-15(18(24)21-17(14)8-13)6-11-2-3-12-9-19-22-16(12)7-11/h2-9H,1H3,(H,19,22)(H,20,23)(H,21,24)/b15-6+ QFMBWTHKAIYHLD-GIDUJCDVSA-N 50437853 CHEMBL2407919 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437853&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189823 175450170 CHEMBL2407919 ZINC96273704 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071490 CC(=O)Nc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 InChI=1S/C18H14N4O2/c1-10(23)20-13-4-5-16-14(8-13)15(18(24)21-16)6-11-2-3-12-9-19-22-17(12)7-11/h2-9H,1H3,(H,19,22)(H,20,23)(H,21,24)/b15-6+ UXFLFGRXPDAOOG-GIDUJCDVSA-N 50437854 CHEMBL2407918 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437854&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 69812178 175450171 CHEMBL2407918 ZINC96273705 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071491 CNC(=O)c1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 InChI=1S/C18H14N4O2/c1-19-17(23)11-4-5-15-13(8-11)14(18(24)21-15)6-10-2-3-12-9-20-22-16(12)7-10/h2-9H,1H3,(H,19,23)(H,20,22)(H,21,24)/b14-6+ MDYWOSMFBZFSBX-MKMNVTDBSA-N 50437861 CHEMBL2407917 Serine/threonine-protein kinase PLK1 Homo sapiens 49000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437861&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189698 175450178 CHEMBL2407917 ZINC96273712 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071492 COc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 InChI=1S/C17H13N3O2/c1-22-12-4-5-15-13(8-12)14(17(21)19-15)6-10-2-3-11-9-18-20-16(11)7-10/h2-9H,1H3,(H,18,20)(H,19,21)/b14-6+ KFZCNVWXULQFPN-MKMNVTDBSA-N 50437862 CHEMBL2407916 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437862&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 68404163 175450179 CHEMBL2407916 ZINC96273713 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071493 Clc1ccc2\C(=C/c3ccc4cn[nH]c4c3)C(=O)Nc2c1 InChI=1S/C16H10ClN3O/c17-11-3-4-12-13(16(21)19-15(12)7-11)5-9-1-2-10-8-18-20-14(10)6-9/h1-8H,(H,18,20)(H,19,21)/b13-5+ LFKWPZDAYPDIKU-WLRTZDKTSA-N 50437855 CHEMBL2407915 Serine/threonine-protein kinase PLK1 Homo sapiens 26000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437855&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189742 175450172 CHEMBL2407915 ZINC96273706 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071494 Clc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 InChI=1S/C16H10ClN3O/c17-11-3-4-14-12(7-11)13(16(21)19-14)5-9-1-2-10-8-18-20-15(10)6-9/h1-8H,(H,18,20)(H,19,21)/b13-5+ ULXYLHILBRICFA-WLRTZDKTSA-N 50437856 CHEMBL2407914 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437856&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189708 175450173 CHEMBL2407914 ZINC96273707 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071495 Fc1ccc2NC(=O)\C(=C/c3ccc4cn[nH]c4c3)c2c1 InChI=1S/C16H10FN3O/c17-11-3-4-14-12(7-11)13(16(21)19-14)5-9-1-2-10-8-18-20-15(10)6-9/h1-8H,(H,18,20)(H,19,21)/b13-5- HOOFEYTZWSBHNO-ACAGNQJTSA-N 50437857 CHEMBL2407913 Serine/threonine-protein kinase PLK1 Homo sapiens 15000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437857&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 69812475 175450174 CHEMBL2407913 ZINC96273708 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071496 Fc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 InChI=1S/C16H10FN3O/c17-11-3-4-14-12(7-11)13(16(21)19-14)5-9-1-2-10-8-18-20-15(10)6-9/h1-8H,(H,18,20)(H,19,21)/b13-5+ HOOFEYTZWSBHNO-WLRTZDKTSA-N 50437860 CHEMBL2407912 Serine/threonine-protein kinase PLK1 Homo sapiens 15000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437860&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189726 175450177 CHEMBL2407912 ZINC96273711 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071497 O=C1Nc2ccccc2\C1=C/c1ccc2cn[nH]c2c1 InChI=1S/C16H11N3O/c20-16-13(12-3-1-2-4-14(12)18-16)7-10-5-6-11-9-17-19-15(11)8-10/h1-9H,(H,17,19)(H,18,20)/b13-7+ MPFUDUPAOWHBRQ-NTUHNPAUSA-N 50437839 CHEMBL2407911 Serine/threonine-protein kinase PLK1 Homo sapiens 24000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437839&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189801 175450156 CHEMBL2407911 ZINC96273692 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071498 O=C1Nc2ccccc2\C1=C\c1ccc2[nH]ncc2c1 InChI=1S/C16H11N3O/c20-16-13(12-3-1-2-4-15(12)18-16)8-10-5-6-14-11(7-10)9-17-19-14/h1-9H,(H,17,19)(H,18,20)/b13-8- HKGXDXUDOHQKPM-JYRVWZFOSA-N 50437858 CHEMBL2407910 Serine/threonine-protein kinase PLK1 Homo sapiens 20000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437858&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 70961331 175450175 CHEMBL2407910 ZINC96273709 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071499 O=C1Nc2ccccc2C1=Cc1ccc2nn[nH]c2c1 InChI=1S/C15H10N4O/c20-15-11(10-3-1-2-4-12(10)16-15)7-9-5-6-13-14(8-9)18-19-17-13/h1-8H,(H,16,20)(H,17,18,19) PXBQEMZXNXEANC-UHFFFAOYSA-N 50437859 CHEMBL2407909 Serine/threonine-protein kinase PLK1 Homo sapiens 29000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437859&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42636270 175450176 CHEMBL2407909 ZINC96273710 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071500 Oc1ccc(\C=C2/C(=O)Nc3ccc(Br)cc23)cc1O InChI=1S/C15H10BrNO3/c16-9-2-3-12-10(7-9)11(15(20)17-12)5-8-1-4-13(18)14(19)6-8/h1-7,18-19H,(H,17,20)/b11-5- JLCLRTONUBKGKP-WZUFQYTHSA-N 50437863 CHEMBL2407908 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437863&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5735633 175450180 CHEMBL2407908 ZINC00099119 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071501 Oc1ccccc1\C=C1/C(=O)Nc2ccccc12 InChI=1S/C15H11NO2/c17-14-8-4-1-5-10(14)9-12-11-6-2-3-7-13(11)16-15(12)18/h1-9,17H,(H,16,18)/b12-9- QJJAFCLEWYTXRC-XFXZXTDPSA-N 50437864 CHEMBL2407907 Serine/threonine-protein kinase PLK1 Homo sapiens 29000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437864&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6510285 175450181 CHEMBL2407907 ZINC12719949 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071502 Oc1cccc(\C=C2/C(=O)Nc3ccccc23)c1 InChI=1S/C15H11NO2/c17-11-5-3-4-10(8-11)9-13-12-6-1-2-7-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9- VHVCSZNJCUZDOG-LCYFTJDESA-N 50437865 CHEMBL2407906 Serine/threonine-protein kinase PLK1 Homo sapiens 25000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437865&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2077962 175450182 CHEMBL2407906 ZINC02616192 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071503 Oc1ccc(\C=C2/C(=O)Nc3ccccc23)cc1 InChI=1S/C15H11NO2/c17-11-7-5-10(6-8-11)9-13-12-3-1-2-4-14(12)16-15(13)18/h1-9,17H,(H,16,18)/b13-9- PLAOAGFXNCEZMZ-LCYFTJDESA-N 50065304 3-[1-(4-Hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one::CHEMBL313578 Serine/threonine-protein kinase PLK1 Homo sapiens 25000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50065304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50065304&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5874584 103960243 CHEMBL313578 ZINC02939076 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071504 COc1cc(\C=C2/C(=O)Nc3ccc(Br)cc23)cc(Br)c1OC InChI=1S/C17H13Br2NO3/c1-22-15-7-9(6-13(19)16(15)23-2)5-12-11-8-10(18)3-4-14(11)20-17(12)21/h3-8H,1-2H3,(H,20,21)/b12-5- DMFNFAMMDAVMRL-XGICHPGQSA-N 50437866 CHEMBL2407905 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437866&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1020400 175450183 CHEMBL2407905 ZINC00684421 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071505 COc1cc(\C=C2/C(=O)N(C)c3ccc(Br)cc23)cc(Cl)c1O InChI=1S/C17H13BrClNO3/c1-20-14-4-3-10(18)8-11(14)12(17(20)22)5-9-6-13(19)16(21)15(7-9)23-2/h3-8,21H,1-2H3/b12-5- GKBCILCXUSENIW-XGICHPGQSA-N 50437867 CHEMBL2407904 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437867&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53529356 175450184 CHEMBL2407904 ZINC69589497 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071506 COc1cc(\C=C2/C(=O)Nc3ccc(Br)cc23)cc(Cl)c1O InChI=1S/C16H11BrClNO3/c1-22-14-6-8(5-12(18)15(14)20)4-11-10-7-9(17)2-3-13(10)19-16(11)21/h2-7,20H,1H3,(H,19,21)/b11-4- ABRWDZBHBOWGSY-WCIBSUBMSA-N 50437868 CHEMBL2407903 Serine/threonine-protein kinase PLK1 Homo sapiens 3600 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437868&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7769752 175450185 CHEMBL2407903 ZINC05675362 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071507 Oc1c(Br)cc(\C=C2/C(=O)Nc3ccc(I)cc23)cc1Br InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3- LMXYVLFTZRPNRV-KMKOMSMNSA-N 50085415 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one::3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one::3-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene]-5-iodo-1,3-dihydro-indol-2-one::CHEMBL72365::G6416 (GW5074)::GW-5074 Serine/threonine-protein kinase PLK1 Homo sapiens 4600 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50085415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50085415&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search GWD 3ETG 5924208 103984884 CHEMBL72365 ZINC16052818 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071508 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51071484 O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccncc3)n[nH]c2c1 InChI=1S/C23H16N4O/c28-23-19(17-3-1-2-4-20(17)25-23)13-16-5-7-18-21(26-27-22(18)14-16)8-6-15-9-11-24-12-10-15/h1-14H,(H,25,28)(H,26,27)/b8-6+,19-13+ CZFUYZPXZGGWKC-SRQUHQSVSA-N 50437838 CHEMBL2407749 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/jm400380m 10.7270/Q2HM59V9 23829549 Laufer, R; Forrest, B; Li, SW; Liu, Y; Sampson, P; Edwards, L; Lang, Y; Awrey, DE; Mao, G; Plotnikova, O; Leung, G; Hodgson, R; Beletskaya, I; Mason, JM; Luo, X; Wei, X; Yao, Y; Feher, M; Ban, F; Kiarash, R; Green, E; Mak, TW; Pan, G; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50437838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50437838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58189810 175450155 CHEMBL2407749 ZINC96273691 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51059642 OCCNC(=O)C1=Cc2c(Nc3ccc(Oc4cccc5sccc45)c(Cl)c3)ncnc2NCC1 InChI=1S/C25H22ClN5O3S/c26-19-13-16(4-5-21(19)34-20-2-1-3-22-17(20)7-11-35-22)31-24-18-12-15(25(33)28-9-10-32)6-8-27-23(18)29-14-30-24/h1-5,7,11-14,32H,6,8-10H2,(H,28,33)(H2,27,29,30,31) QHUDPFOODLMGQO-UHFFFAOYSA-N 50432373 CHEMBL2348417 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2013.02.014 10.7270/Q2TT4S9D 23490150 Kawakita, Y; Seto, M; Ohashi, T; Tamura, T; Yusa, T; Miki, H; Iwata, H; Kamiguchi, H; Tanaka, T; Sogabe, S; Ohta, Y; Ishikawa, T Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432373&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search W19 3W33 71583657 164161248 CHEMBL2348417 C04080 ZINC95604501 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067347 CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3N(C)C(=O)C(F)(F)CN(C4CCCC4)c3n2)cc1C InChI=1S/C27H35F2N7O2/c1-17-14-19(8-9-21(17)24(37)31-18-10-12-34(2)13-11-18)32-26-30-15-22-23(33-26)36(20-6-4-5-7-20)16-27(28,29)25(38)35(22)3/h8-9,14-15,18,20H,4-7,10-13,16H2,1-3H3,(H,31,37)(H,30,32,33) WQQPBXGJFFKXKX-UHFFFAOYSA-N 50435721 CHEMBL2392551 Serine/threonine-protein kinase PLK1 Homo sapiens 190 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435721&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57955606 175448038 CHEMBL2392551 ZINC96271644 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067348 COc1cc(Nc2ncc3N(C)C(=O)C(F)(F)CN(C4CCCC4)c3n2)ccc1C(=O)NC1CCN(C)CC1 InChI=1S/C27H35F2N7O3/c1-34-12-10-17(11-13-34)31-24(37)20-9-8-18(14-22(20)39-3)32-26-30-15-21-23(33-26)36(19-6-4-5-7-19)16-27(28,29)25(38)35(21)2/h8-9,14-15,17,19H,4-7,10-13,16H2,1-3H3,(H,31,37)(H,30,32,33) JMBATVPHKFZTAF-UHFFFAOYSA-N 50435722 CHEMBL2392550 Serine/threonine-protein kinase PLK1 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435722&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57955660 175448039 CHEMBL2392550 ZINC96271645 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067349 COc1cc(C(=O)NC2CCN(C)CC2)c(Cl)cc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1 InChI=1S/C27H34ClF2N7O3/c1-35-10-8-16(9-11-35)32-24(38)18-12-22(40-3)20(13-19(18)28)33-26-31-14-21-23(34-26)37(17-6-4-5-7-17)15-27(29,30)25(39)36(21)2/h12-14,16-17H,4-11,15H2,1-3H3,(H,32,38)(H,31,33,34) AEWBIFRPDTZPLO-UHFFFAOYSA-N 50435723 CHEMBL2392549 Serine/threonine-protein kinase PLK1 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435723&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71654873 175448040 CHEMBL2392549 ZINC96271646 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067350 CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3N(C)C(=O)C(F)(F)CN(C4CCCC4)c3n2)cc1 InChI=1S/C26H33F2N7O2/c1-33-13-11-19(12-14-33)30-23(36)17-7-9-18(10-8-17)31-25-29-15-21-22(32-25)35(20-5-3-4-6-20)16-26(27,28)24(37)34(21)2/h7-10,15,19-20H,3-6,11-14,16H2,1-2H3,(H,30,36)(H,29,31,32) BAVKHKJJAGWXBX-UHFFFAOYSA-N 50435724 CHEMBL2392548 Serine/threonine-protein kinase PLK1 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435724&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25253525 175448041 CHEMBL2392548 ZINC59223233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067351 COc1c(Nc2ncc3N(C)C(=O)C(F)(F)CN(C4CCCC4)c3n2)ccc(C(=O)NC2CCN(C)CC2)c1F InChI=1S/C27H34F3N7O3/c1-35-12-10-16(11-13-35)32-24(38)18-8-9-19(22(40-3)21(18)28)33-26-31-14-20-23(34-26)37(17-6-4-5-7-17)15-27(29,30)25(39)36(20)2/h8-9,14,16-17H,4-7,10-13,15H2,1-3H3,(H,32,38)(H,31,33,34) RXDSAQWDJRAMCT-UHFFFAOYSA-N 50435725 CHEMBL2392547 Serine/threonine-protein kinase PLK1 Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435725&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57955580 175448042 CHEMBL2392547 ZINC96271647 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067352 COc1cc(cc(F)c1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C27H34F3N7O3/c1-35-10-8-17(9-11-35)32-24(38)16-12-19(28)22(21(13-16)40-3)33-26-31-14-20-23(34-26)37(18-6-4-5-7-18)15-27(29,30)25(39)36(20)2/h12-14,17-18H,4-11,15H2,1-3H3,(H,32,38)(H,31,33,34) WYSOLHCQRQBXQP-UHFFFAOYSA-N 50435726 CHEMBL2392546 Serine/threonine-protein kinase PLK1 Homo sapiens 81 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435726&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57955668 175448043 CHEMBL2392546 ZINC96271648 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067353 COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1 InChI=1S/C27H34F3N7O3/c1-35-10-8-16(9-11-35)32-24(38)18-12-22(40-3)20(13-19(18)28)33-26-31-14-21-23(34-26)37(17-6-4-5-7-17)15-27(29,30)25(39)36(21)2/h12-14,16-17H,4-11,15H2,1-3H3,(H,32,38)(H,31,33,34) GWRSATNRNFYMDI-UHFFFAOYSA-N 50435727 CHEMBL2392545 Serine/threonine-protein kinase PLK1 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435727&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1J4 4J53 53357478 175448044 CHEMBL2392545 ZINC43203898 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067354 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@](F)(CN(C3CCCC3)c2n1)C=C)C(=O)NN1CCN(C)CC1 InChI=1S/C28H37FN8O3/c1-5-28(29)18-37(20-8-6-7-9-20)24-22(35(3)26(28)39)17-30-27(32-24)31-21-11-10-19(16-23(21)40-4)25(38)33-36-14-12-34(2)13-15-36/h5,10-11,16-17,20H,1,6-9,12-15,18H2,2-4H3,(H,33,38)(H,30,31,32)/t28-/m1/s1 IVRPFXYSCCXTAK-MUUNZHRXSA-N 50435728 CHEMBL2392544 Serine/threonine-protein kinase PLK1 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435728&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1J3 4J52 25253376 175448045 CHEMBL2392544 ZINC59222686 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067355 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@](F)(CN(C3CCCC3)c2n1)C=C)C(=O)NC1CCN(C)CC1 InChI=1S/C29H38FN7O3/c1-5-29(30)18-37(21-8-6-7-9-21)25-23(36(3)27(29)39)17-31-28(34-25)33-22-11-10-19(16-24(22)40-4)26(38)32-20-12-14-35(2)15-13-20/h5,10-11,16-17,20-21H,1,6-9,12-15,18H2,2-4H3,(H,32,38)(H,31,33,34)/t29-/m0/s1 RBXLZSWSJTUVKC-LJAQVGFWSA-N 50435729 CHEMBL2392543 Serine/threonine-protein kinase PLK1 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435729&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25253226 175448046 CHEMBL2392543 ZINC59222683 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067356 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@](F)(CN(C3CCCC3)c2n1)C=C)C(=O)NC1CCN(C)CC1 InChI=1S/C29H38FN7O3/c1-5-29(30)18-37(21-8-6-7-9-21)25-23(36(3)27(29)39)17-31-28(34-25)33-22-11-10-19(16-24(22)40-4)26(38)32-20-12-14-35(2)15-13-20/h5,10-11,16-17,20-21H,1,6-9,12-15,18H2,2-4H3,(H,32,38)(H,31,33,34)/t29-/m1/s1 RBXLZSWSJTUVKC-GDLZYMKVSA-N 50435730 CHEMBL2392558 Serine/threonine-protein kinase PLK1 Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435730&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25253225 175448047 CHEMBL2392558 ZINC59222682 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067357 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@H](CC=C)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C30H41N7O3/c1-5-8-21-19-37(23-9-6-7-10-23)27-25(36(3)29(21)39)18-31-30(34-27)33-24-12-11-20(17-26(24)40-4)28(38)32-22-13-15-35(2)16-14-22/h5,11-12,17-18,21-23H,1,6-10,13-16,19H2,2-4H3,(H,32,38)(H,31,33,34)/t21-/m1/s1 DWBXNQKRJAOIHK-OAQYLSRUSA-N 50435731 CHEMBL2392557 Serine/threonine-protein kinase PLK1 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435731&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57969945 175448048 CHEMBL2392557 ZINC96271649 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067358 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC=C)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C30H41N7O3/c1-5-8-21-19-37(23-9-6-7-10-23)27-25(36(3)29(21)39)18-31-30(34-27)33-24-12-11-20(17-26(24)40-4)28(38)32-22-13-15-35(2)16-14-22/h5,11-12,17-18,21-23H,1,6-10,13-16,19H2,2-4H3,(H,32,38)(H,31,33,34)/t21-/m0/s1 DWBXNQKRJAOIHK-NRFANRHFSA-N 50435732 CHEMBL2392556 Serine/threonine-protein kinase PLK1 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435732&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 57970023 175448049 CHEMBL2392556 ZINC96271650 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067359 CC[C@]1(F)CN(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C29H40FN7O3/c1-5-29(30)18-37(21-8-6-7-9-21)25-23(36(3)27(29)39)17-31-28(34-25)33-22-11-10-19(16-24(22)40-4)26(38)32-20-12-14-35(2)15-13-20/h10-11,16-17,20-21H,5-9,12-15,18H2,1-4H3,(H,32,38)(H,31,33,34)/t29-/m0/s1 QEIJYXMTALGXJH-LJAQVGFWSA-N 50435733 CHEMBL2392555 Serine/threonine-protein kinase PLK1 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435733&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25252911 175448050 CHEMBL2392555 ZINC59222517 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067360 CC[C@@]1(F)CN(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C29H40FN7O3/c1-5-29(30)18-37(21-8-6-7-9-21)25-23(36(3)27(29)39)17-31-28(34-25)33-22-11-10-19(16-24(22)40-4)26(38)32-20-12-14-35(2)15-13-20/h10-11,16-17,20-21H,5-9,12-15,18H2,1-4H3,(H,32,38)(H,31,33,34)/t29-/m1/s1 QEIJYXMTALGXJH-GDLZYMKVSA-N 50435734 CHEMBL2392554 Serine/threonine-protein kinase PLK1 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435734&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 25252909 175448051 CHEMBL2392554 ZINC59222516 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067361 COc1cc(ccc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C27H35F2N7O3/c1-34-12-10-18(11-13-34)31-24(37)17-8-9-20(22(14-17)39-3)32-26-30-15-21-23(33-26)36(19-6-4-5-7-19)16-27(28,29)25(38)35(21)2/h8-9,14-15,18-19H,4-7,10-13,16H2,1-3H3,(H,31,37)(H,30,32,33) DJNZZLZKAXGMMC-UHFFFAOYSA-N 50435735 CHEMBL2392553 Serine/threonine-protein kinase PLK1 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435735&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 79C 7BJY,7LAJ,5VBP,7L9J,5TA8,7L72 25015677 175448052 CHEMBL2392553 ZINC96271651 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51067362 COc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C27H37N7O3/c1-32-13-10-19(11-14-32)29-26(36)18-8-9-21(23(16-18)37-3)30-27-28-17-22-25(31-27)34(20-6-4-5-7-20)15-12-24(35)33(22)2/h8-9,16-17,19-20H,4-7,10-15H2,1-3H3,(H,29,36)(H,28,30,31) JFRNFMQDZRWAQB-UHFFFAOYSA-N 50435736 CHEMBL2392552::US9266890, I-3 Serine/threonine-protein kinase PLK1 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2013.02.083 10.7270/Q2ST7R8C 23664874 Nie, Z; Feher, V; Natala, S; McBride, C; Kiryanov, A; Jones, B; Lam, B; Liu, Y; Kaldor, S; Stafford, J; Hikami, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Matsumoto, S; Amano, N; Zhang, L; Hosfield, D; Skene, R; Zou, H; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435736&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16722190 175448053 CHEMBL2392552 ZINC43172166 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51063462 CC(=O)Nc1cccc(c1)-c1n[nH]c2cc(-c3cnn(C)c3)c(NC3CCCCC3)cc12 InChI=1S/C25H28N6O/c1-16(32)27-20-10-6-7-17(11-20)25-22-13-23(28-19-8-4-3-5-9-19)21(12-24(22)29-30-25)18-14-26-31(2)15-18/h6-7,10-15,19,28H,3-5,8-9H2,1-2H3,(H,27,32)(H,29,30) RIOJOTOJNAHBST-UHFFFAOYSA-N 50433902 CHEMBL2380587 Serine/threonine-protein kinase PLK1 Homo sapiens >5000 ChEMBL 10.1021/jm4000215 10.7270/Q2SF2XJB 23634759 Kusakabe, K; Ide, N; Daigo, Y; Tachibana, Y; Itoh, T; Yamamoto, T; Hashizume, H; Hato, Y; Higashino, K; Okano, Y; Sato, Y; Inoue, M; Iguchi, M; Kanazawa, T; Ishioka, Y; Dohi, K; Kido, Y; Sakamoto, S; Yasuo, K; Maeda, M; Higaki, M; Ueda, K; Yoshizawa, H; Baba, Y; Shiota, T; Murai, H; Nakamura, Y Shionogi Pharmaceutical Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433902&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71682457 175446219 CHEMBL2380587 ZINC96270039 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51063463 Cn1cc(cn1)-c1cc2[nH]nc(-c3cccc(c3)S(N)(=O)=O)c2cc1NC1CCCCC1 InChI=1S/C23H26N6O2S/c1-29-14-16(13-25-29)19-11-22-20(12-21(19)26-17-7-3-2-4-8-17)23(28-27-22)15-6-5-9-18(10-15)32(24,30)31/h5-6,9-14,17,26H,2-4,7-8H2,1H3,(H,27,28)(H2,24,30,31) PUJKNBHSGMNWBW-UHFFFAOYSA-N 50433903 CHEMBL2380586 Serine/threonine-protein kinase PLK1 Homo sapiens >5000 ChEMBL 10.1021/jm4000215 10.7270/Q2SF2XJB 23634759 Kusakabe, K; Ide, N; Daigo, Y; Tachibana, Y; Itoh, T; Yamamoto, T; Hashizume, H; Hato, Y; Higashino, K; Okano, Y; Sato, Y; Inoue, M; Iguchi, M; Kanazawa, T; Ishioka, Y; Dohi, K; Kido, Y; Sakamoto, S; Yasuo, K; Maeda, M; Higaki, M; Ueda, K; Yoshizawa, H; Baba, Y; Shiota, T; Murai, H; Nakamura, Y Shionogi Pharmaceutical Research Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433903&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54675539 175446220 CHEMBL2380586 ZINC96270040 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51062447 CC(C)C[C@@H]1NC(=O)CN(CCC(=O)NCCc2c[nH]c3ccccc23)C(=O)CSC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C39H56N11O13PS/c1-21(2)12-27-36(56)46-28(13-24-15-41-20-44-24)37(57)47-29(17-51)38(58)49-34(22(3)63-64(60,61)62)39(59)48-30(35(40)55)18-65-19-33(54)50(16-32(53)45-27)11-9-31(52)42-10-8-23-14-43-26-7-5-4-6-25(23)26/h4-7,14-15,20-22,27-30,34,43,51H,8-13,16-19H2,1-3H3,(H2,40,55)(H,41,44)(H,42,52)(H,45,53)(H,46,56)(H,47,57)(H,48,59)(H,49,58)(H2,60,61,62)/t22-,27+,28+,29+,30-,34+/m1/s1 QECCEBUDDKKVOA-KQFQEUIISA-N 50433413 CHEMBL2380651 Serine/threonine-protein kinase PLK1 Homo sapiens 4750 ChEMBL 10.1016/j.bmc.2013.02.020 10.7270/Q2J38TZ4 23498919 Murugan, RN; Park, JE; Lim, D; Ahn, M; Cheong, C; Kwon, T; Nam, KY; Choi, SH; Kim, BY; Yoon, DY; Yaffe, MB; Yu, DY; Lee, KS; Bang, JK Korea Basic Science Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433413&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71603063 175445730 CHEMBL2380651 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51062448 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O InChI=1S/C71H102N16O22/c1-9-36(4)56(67(105)77-46(59(72)97)28-42-19-21-44(92)22-20-42)83-60(98)37(5)75-68(106)57(38(6)89)85-65(103)51(33-88)82-64(102)49(30-43-32-73-34-74-43)78-62(100)47(27-35(2)3)79-66(104)52-17-13-25-86(52)71(109)53-18-14-26-87(53)70(108)50(31-55(95)96)81-63(101)48(29-41-15-11-10-12-16-41)80-69(107)58(39(7)90)84-61(99)45(76-40(8)91)23-24-54(93)94/h10-12,15-16,19-22,32,34-39,45-53,56-58,88-90,92H,9,13-14,17-18,23-31,33H2,1-8H3,(H2,72,97)(H,73,74)(H,75,106)(H,76,91)(H,77,105)(H,78,100)(H,79,104)(H,80,107)(H,81,101)(H,82,102)(H,83,98)(H,84,99)(H,85,103)(H,93,94)(H,95,96)/t36-,37-,38+,39+,45-,46-,47-,48-,49-,50-,51-,52-,53-,56-,57-,58-/m0/s1 QPBYPJKNTKPWHP-XRSOISPESA-N 50433414 CHEMBL2380650 Serine/threonine-protein kinase PLK1 Homo sapiens 120 ChEMBL 10.1016/j.bmc.2013.02.020 10.7270/Q2J38TZ4 23498919 Murugan, RN; Park, JE; Lim, D; Ahn, M; Cheong, C; Kwon, T; Nam, KY; Choi, SH; Kim, BY; Yoon, DY; Yaffe, MB; Yu, DY; Lee, KS; Bang, JK Korea Basic Science Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433414&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 73351931 175445731 CHEMBL2380650 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51062449 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 IYLBMSHZRRWSRM-FALOATQWSA-N 50426931 CHEMBL2323729 Serine/threonine-protein kinase PLK1 Homo sapiens 32030 ChEMBL 10.1016/j.bmc.2013.02.020 10.7270/Q2J38TZ4 23498919 Murugan, RN; Park, JE; Lim, D; Ahn, M; Cheong, C; Kwon, T; Nam, KY; Choi, SH; Kim, BY; Yoon, DY; Yaffe, MB; Yu, DY; Lee, KS; Bang, JK Korea Basic Science Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42608451 164155806 CHEMBL2323729 ZINC95584623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51062450 CC(C)C[C@@H]1NC(=O)CN(CCCCCC(=O)NCCc2cn(C(C)=O)c3ccccc23)C(=O)CSC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cncn2CCCCCCCCc2ccccc2)NC1=O)[C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C58H84N11O14PS/c1-38(2)29-45-55(76)63-46(30-43-31-60-37-68(43)28-17-8-6-5-7-11-19-41-20-12-9-13-21-41)56(77)64-47(34-70)57(78)66-53(39(3)83-84(80,81)82)58(79)65-48(54(59)75)35-85-36-52(74)67(33-51(73)62-45)27-18-10-14-24-50(72)61-26-25-42-32-69(40(4)71)49-23-16-15-22-44(42)49/h9,12-13,15-16,20-23,31-32,37-39,45-48,53,70H,5-8,10-11,14,17-19,24-30,33-36H2,1-4H3,(H2,59,75)(H,61,72)(H,62,73)(H,63,76)(H,64,77)(H,65,79)(H,66,78)(H2,80,81,82)/t39-,45+,46+,47+,48-,53+/m1/s1 DEHXVDBTGRNEJG-GSESMZNDSA-N 50433415 CHEMBL2380764 Serine/threonine-protein kinase PLK1 Homo sapiens 1080 ChEMBL 10.1016/j.bmc.2013.02.020 10.7270/Q2J38TZ4 23498919 Murugan, RN; Park, JE; Lim, D; Ahn, M; Cheong, C; Kwon, T; Nam, KY; Choi, SH; Kim, BY; Yoon, DY; Yaffe, MB; Yu, DY; Lee, KS; Bang, JK Korea Basic Science Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433415&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71603062 175445732 CHEMBL2380764 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51062451 CC(C)C[C@@H]1NC(=O)CN(CCCCCC(=O)NCCc2cn(C(C)=O)c3ccccc23)C(=O)CSC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C44H64N11O14PS/c1-25(2)16-31-41(62)50-32(17-29-18-46-24-48-29)42(63)51-33(21-56)43(64)53-39(26(3)69-70(66,67)68)44(65)52-34(40(45)61)22-71-23-38(60)54(20-37(59)49-31)15-9-5-6-12-36(58)47-14-13-28-19-55(27(4)57)35-11-8-7-10-30(28)35/h7-8,10-11,18-19,24-26,31-34,39,56H,5-6,9,12-17,20-23H2,1-4H3,(H2,45,61)(H,46,48)(H,47,58)(H,49,59)(H,50,62)(H,51,63)(H,52,65)(H,53,64)(H2,66,67,68)/t26-,31+,32+,33+,34-,39+/m1/s1 OORPAHIABJKOQZ-QMBSKNLRSA-N 50433416 CHEMBL2380660 Serine/threonine-protein kinase PLK1 Homo sapiens 2560 ChEMBL 10.1016/j.bmc.2013.02.020 10.7270/Q2J38TZ4 23498919 Murugan, RN; Park, JE; Lim, D; Ahn, M; Cheong, C; Kwon, T; Nam, KY; Choi, SH; Kim, BY; Yoon, DY; Yaffe, MB; Yu, DY; Lee, KS; Bang, JK Korea Basic Science Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433416&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71603001 175445733 CHEMBL2380660 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51062452 CC(C)C[C@@H]1NC(=O)CN(CCc2c[nH]c3ccccc23)C(=O)CSC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C36H51N10O12PS/c1-19(2)10-25-33(51)42-26(11-22-13-38-18-40-22)34(52)43-27(15-47)35(53)45-31(20(3)58-59(55,56)57)36(54)44-28(32(37)50)16-60-17-30(49)46(14-29(48)41-25)9-8-21-12-39-24-7-5-4-6-23(21)24/h4-7,12-13,18-20,25-28,31,39,47H,8-11,14-17H2,1-3H3,(H2,37,50)(H,38,40)(H,41,48)(H,42,51)(H,43,52)(H,44,54)(H,45,53)(H2,55,56,57)/t20-,25+,26+,27+,28-,31+/m1/s1 DDUIKWXPFWIAGL-OMAZYLPNSA-N 50433417 CHEMBL2380653 Serine/threonine-protein kinase PLK1 Homo sapiens 8500 ChEMBL 10.1016/j.bmc.2013.02.020 10.7270/Q2J38TZ4 23498919 Murugan, RN; Park, JE; Lim, D; Ahn, M; Cheong, C; Kwon, T; Nam, KY; Choi, SH; Kim, BY; Yoon, DY; Yaffe, MB; Yu, DY; Lee, KS; Bang, JK Korea Basic Science Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433417&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71602897 175445734 CHEMBL2380653 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51062453 CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)CSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)[C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C29H45N8O13PS/c1-14(2)7-17-24(40)32-18(8-16-9-30-13-31-16)25(41)34-19(10-38)26(42)36-23(15(3)50-51(47,48)49)28(44)35-20(29(45)46)11-52-12-22(39)37-6-4-5-21(37)27(43)33-17/h9,13-15,17-21,23,38H,4-8,10-12H2,1-3H3,(H,30,31)(H,32,40)(H,33,43)(H,34,41)(H,35,44)(H,36,42)(H,45,46)(H2,47,48,49)/t15-,17+,18+,19+,20+,21+,23+/m1/s1 JLXBABLXNALFOP-IHNFJAPISA-N 50433418 CHEMBL2380765 Serine/threonine-protein kinase PLK1 Homo sapiens 9800 ChEMBL 10.1016/j.bmc.2013.02.020 10.7270/Q2J38TZ4 23498919 Murugan, RN; Park, JE; Lim, D; Ahn, M; Cheong, C; Kwon, T; Nam, KY; Choi, SH; Kim, BY; Yoon, DY; Yaffe, MB; Yu, DY; Lee, KS; Bang, JK Korea Basic Science Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433418&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 73354910 175445735 CHEMBL2380765 ZINC96269577 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538498 CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16- CMOJHDQJJPIVEC-MNDPQUGUSA-N 50206448 CHEMBL3944542 Serine/threonine-protein kinase PLK1 Homo sapiens 29400 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206448&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9613592 375981109 CHEMBL3944542 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538499 NS(=O)(=O)c1cc(Cl)c(NC(=S)NC(=O)c2ccccc2)c(Cl)c1 InChI=1S/C14H11Cl2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) PWQQARVQUOFCKD-UHFFFAOYSA-N 50206449 CHEMBL3944679 Serine/threonine-protein kinase PLK1 Homo sapiens 5100 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206449&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 981550 375981110 CHEMBL3944679 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538500 NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccccc2)c(I)c1 InChI=1S/C14H12IN3O3S2/c15-11-8-10(23(16,20)21)6-7-12(11)17-14(22)18-13(19)9-4-2-1-3-5-9/h1-8H,(H2,16,20,21)(H2,17,18,19,22) OAWQPZYLVMNEQV-UHFFFAOYSA-N 50206450 CHEMBL3921162 Serine/threonine-protein kinase PLK1 Homo sapiens 5600 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206450&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134140264 375981111 CHEMBL3921162 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538501 CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16- CMOJHDQJJPIVEC-MNDPQUGUSA-N 50206448 CHEMBL3944542 Serine/threonine-protein kinase PLK1 Homo sapiens 10500 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206448&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9613592 375981109 CHEMBL3944542 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538502 NS(=O)(=O)c1cc(Br)c(NC(=S)NC(=O)c2ccccc2)c(Br)c1 InChI=1S/C14H11Br2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) NDKOLPRDQQUJPD-UHFFFAOYSA-N 50206451 CHEMBL3894239 Serine/threonine-protein kinase PLK1 Homo sapiens 95000 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206451&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134137232 375981112 CHEMBL3894239 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538503 NS(=O)(=O)c1cc(Br)c(NC(=S)NC(=O)c2ccccc2)c(Br)c1 InChI=1S/C14H11Br2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) NDKOLPRDQQUJPD-UHFFFAOYSA-N 50206451 CHEMBL3894239 Serine/threonine-protein kinase PLK1 Homo sapiens 39800 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206451&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134137232 375981112 CHEMBL3894239 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538504 NS(=O)(=O)c1cc(Br)c(NC(=S)NC(=O)c2ccccc2)c(Br)c1 InChI=1S/C14H11Br2N3O3S2/c15-10-6-9(24(17,21)22)7-11(16)12(10)18-14(23)19-13(20)8-4-2-1-3-5-8/h1-7H,(H2,17,21,22)(H2,18,19,20,23) NDKOLPRDQQUJPD-UHFFFAOYSA-N 50206451 CHEMBL3894239 Serine/threonine-protein kinase PLK1 Homo sapiens 2300 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206451&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134137232 375981112 CHEMBL3894239 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538505 NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccccc2)cc1 InChI=1S/C14H13N3O3S2/c15-22(19,20)12-8-6-11(7-9-12)16-14(21)17-13(18)10-4-2-1-3-5-10/h1-9H,(H2,15,19,20)(H2,16,17,18,21) OFLIERYFTMBNIX-UHFFFAOYSA-N 50005003 CHEMBL2392423 Serine/threonine-protein kinase PLK1 Homo sapiens 68800 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005003&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 780268 103918550 CHEMBL2392423 ZINC13455193 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538506 CC(=O)NC(=S)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C9H11N3O3S2/c1-6(13)11-9(16)12-7-2-4-8(5-3-7)17(10,14)15/h2-5H,1H3,(H2,10,14,15)(H2,11,12,13,16) WLDRMKNHJPYWFK-UHFFFAOYSA-N 50206452 CHEMBL3908343 Serine/threonine-protein kinase PLK1 Homo sapiens 73700 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206452&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 974380 375981113 CHEMBL3908343 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538507 CCC(=O)NC(=S)Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C10H13N3O3S2/c1-2-9(14)13-10(17)12-7-3-5-8(6-4-7)18(11,15)16/h3-6H,2H2,1H3,(H2,11,15,16)(H2,12,13,14,17) MINZOXPPMXZLJA-UHFFFAOYSA-N 50206453 CHEMBL3978761 Serine/threonine-protein kinase PLK1 Homo sapiens 64300 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206453&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 833390 375981114 CHEMBL3978761 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538508 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C31H49N8O13P/c1-16(2)11-20(35-28(44)23-7-5-9-38(23)18(4)41)26(42)34-21(12-19-13-32-15-33-19)27(43)36-22(14-40)30(46)39-10-6-8-24(39)29(45)37-25(31(47)48)17(3)52-53(49,50)51/h13,15-17,20-25,40H,5-12,14H2,1-4H3,(H,32,33)(H,34,42)(H,35,44)(H,36,43)(H,37,45)(H,47,48)(H2,49,50,51)/t17-,20+,21+,22+,23+,24+,25+/m1/s1 SQVSWUYZOTZMOD-AGZZQPQKSA-N 50206454 CHEMBL3928373 Serine/threonine-protein kinase PLK1 Homo sapiens 14000 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206454&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134140931 375981115 CHEMBL3928373 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50538509 NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccccc2)c(Br)c1 InChI=1S/C14H12BrN3O3S2/c15-11-8-10(23(16,20)21)6-7-12(11)17-14(22)18-13(19)9-4-2-1-3-5-9/h1-8H,(H2,16,20,21)(H2,17,18,19,22) FNZRXCZRWNKIDV-UHFFFAOYSA-N 50206455 CHEMBL3922258 Serine/threonine-protein kinase PLK1 Homo sapiens 6900 ChEMBL 10.1016/j.ejmech.2016.08.043 10.7270/Q22F7QFW 27592392 Yun, T; Qin, T; Liu, Y; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206455&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134139823 375981116 CHEMBL3922258 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50546882 CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12 InChI=1S/C23H22N4O2/c1-23(2)17-13-24-22(25-14-7-4-3-5-8-14)26-20(17)27(21(23)29)18-12-11-16-15(18)9-6-10-19(16)28/h3-10,13,18,28H,11-12H2,1-2H3,(H,24,25,26)/t18-/m0/s1 XLFNLJYGUOLEJS-SFHVURJKSA-N 50208911 CHEMBL3884319 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2016.08.068 10.7270/Q2N018JC 27816515 Katz, JD; Haidle, A; Childers, KK; Zabierek, AA; Jewell, JP; Hou, Y; Altman, MD; Szewczak, A; Chen, D; Harsch, A; Hayashi, M; Warren, L; Hutton, M; Nuthall, H; Su, HP; Munshi, S; Stanton, MG; Davies, IW; Munoz, B; Northrup, A Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208911&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 69036886 375982220 CHEMBL3884319 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50552351 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1038/nrd.2016.266 10.7270/Q2125VNC 28280261 Munoz, L The University of Sydney http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50552386 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 0.870000 ChEMBL 10.1038/nrd.2016.266 10.7270/Q2125VNC 28280261 Munoz, L The University of Sydney http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687751 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C#N)c12 InChI=1S/C30H36FN9O2/c1-4-24-27-23(15-32)34-17-39(27)25-16-33-30(37-28(25)40(24)19-7-5-6-8-19)36-22-14-21(31)20(13-26(22)42-3)29(41)35-18-9-11-38(2)12-10-18/h13-14,16-19,24H,4-12H2,1-3H3,(H,35,41)(H,33,36,37)/t24-/m1/s1 XFQQKFNFMHVKGP-XMMPIXPASA-N 50232578 CHEMBL4066163 Serine/threonine-protein kinase PLK1 Homo sapiens 2.2 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232578&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137631881 384226816 CHEMBL4066163 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687752 CC[C@H]1N(C(C)C)c2nc(Nc3cc(F)c(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C#N)c12 InChI=1S/C28H34FN9O2/c1-6-22-25-21(13-30)32-15-37(25)23-14-31-28(35-26(23)38(22)16(2)3)34-20-12-19(29)18(11-24(20)40-5)27(39)33-17-7-9-36(4)10-8-17/h11-12,14-17,22H,6-10H2,1-5H3,(H,33,39)(H,31,34,35)/t22-/m1/s1 UMYZHTXQBNEZNF-JOCHJYFZSA-N 50232579 CHEMBL4103908 Serine/threonine-protein kinase PLK1 Homo sapiens 1.9 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137657338 384226817 CHEMBL4103908 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687753 CC[C@H]1N(C2CCCCC2)c2nc(Nc3cc(F)c(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C#N)c12 InChI=1S/C31H38FN9O2/c1-4-25-28-24(16-33)35-18-40(28)26-17-34-31(38-29(26)41(25)20-8-6-5-7-9-20)37-23-15-22(32)21(14-27(23)43-3)30(42)36-19-10-12-39(2)13-11-19/h14-15,17-20,25H,4-13H2,1-3H3,(H,36,42)(H,34,37,38)/t25-/m1/s1 XKVZTXMZBWFWRQ-RUZDIDTESA-N 50232580 CHEMBL4078098 Serine/threonine-protein kinase PLK1 Homo sapiens 1.3 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232580&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137648903 384226818 CHEMBL4078098 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687754 CC[C@H]1N(C(C)C)c2nc(Nc3cc(F)c(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2-n2cnc(C#N)c12 InChI=1S/C36H47FN10O2/c1-5-30-33-29(18-38)40-21-46(33)31-19-39-36(43-34(31)47(30)22(2)3)42-28-17-27(37)26(16-32(28)49-4)35(48)41-24-8-10-25(11-9-24)45-14-12-44(13-15-45)20-23-6-7-23/h16-17,19,21-25,30H,5-15,20H2,1-4H3,(H,41,48)(H,39,42,43)/t24-,25-,30-/m1/s1 CKAZLPSHMQDEHE-OYPUMOIUSA-N 50232581 CHEMBL4096151 Serine/threonine-protein kinase PLK1 Homo sapiens 3.9 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232581&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44634484 384226819 CHEMBL4096151 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687755 CC[C@H]1N(C(C)C)c2nc(Nc3cc(F)c(cc3OC)C(=O)NC3CCN(CC)CC3)ncc2-n2cnc(C#N)c12 InChI=1S/C29H36FN9O2/c1-6-23-26-22(14-31)33-16-38(26)24-15-32-29(36-27(24)39(23)17(3)4)35-21-13-20(30)19(12-25(21)41-5)28(40)34-18-8-10-37(7-2)11-9-18/h12-13,15-18,23H,6-11H2,1-5H3,(H,34,40)(H,32,35,36)/t23-/m1/s1 NVZUHQUNIGVGBQ-HSZRJFAPSA-N 50232582 CHEMBL4067710 Serine/threonine-protein kinase PLK1 Homo sapiens 0.400000 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232582&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137633635 384226820 CHEMBL4067710 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687760 CCOC(=O)c1ncn-2c1[C@@H](CC)N(C1CCCC1)c1nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc-21 InChI=1S/C32H42N8O4/c1-5-24-28-27(31(42)44-6-2)34-19-39(28)25-18-33-32(37-29(25)40(24)22-9-7-8-10-22)36-23-12-11-20(17-26(23)43-4)30(41)35-21-13-15-38(3)16-14-21/h11-12,17-19,21-22,24H,5-10,13-16H2,1-4H3,(H,35,41)(H,33,36,37)/t24-/m1/s1 KRKASDMDACZHLR-XMMPIXPASA-N 50232584 CHEMBL4074112 Serine/threonine-protein kinase PLK1 Homo sapiens 2.1 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232584&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137640632 384226822 CHEMBL4074112 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687761 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C(N)=O)c12 InChI=1S/C30H39N9O3/c1-4-22-26-25(27(31)40)33-17-38(26)23-16-32-30(36-28(23)39(22)20-7-5-6-8-20)35-21-10-9-18(15-24(21)42-3)29(41)34-19-11-13-37(2)14-12-19/h9-10,15-17,19-20,22H,4-8,11-14H2,1-3H3,(H2,31,40)(H,34,41)(H,32,35,36)/t22-/m1/s1 AWYSFWYRQPHWJL-JOCHJYFZSA-N 50232585 CHEMBL4063398 Serine/threonine-protein kinase PLK1 Homo sapiens 2.0 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232585&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137637120 384226823 CHEMBL4063398 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687781 CCNC(=O)c1ncn-2c1[C@@H](CC)N(C1CCCC1)c1nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc-21 InChI=1S/C32H43N9O3/c1-5-24-28-27(31(43)33-6-2)35-19-40(28)25-18-34-32(38-29(25)41(24)22-9-7-8-10-22)37-23-12-11-20(17-26(23)44-4)30(42)36-21-13-15-39(3)16-14-21/h11-12,17-19,21-22,24H,5-10,13-16H2,1-4H3,(H,33,43)(H,36,42)(H,34,37,38)/t24-/m1/s1 IYWCICTYSWDBDQ-XMMPIXPASA-N 50232586 CHEMBL4085036 Serine/threonine-protein kinase PLK1 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232586&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137648227 384226824 CHEMBL4085036 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687784 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C#N)c12 InChI=1S/C30H37N9O2/c1-4-24-27-23(16-31)33-18-38(27)25-17-32-30(36-28(25)39(24)21-7-5-6-8-21)35-22-10-9-19(15-26(22)41-3)29(40)34-20-11-13-37(2)14-12-20/h9-10,15,17-18,20-21,24H,4-8,11-14H2,1-3H3,(H,34,40)(H,32,35,36)/t24-/m1/s1 UJEXFMKGBVBXPF-XMMPIXPASA-N 50232583 CHEMBL4074778 Serine/threonine-protein kinase PLK1 Homo sapiens 1.5 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232583&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 79D 5TA6 124201651 384226821 CHEMBL4074778 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687798 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C(=O)N(C)O)c12 InChI=1S/C31H41N9O4/c1-5-23-27-26(30(42)38(3)43)33-18-39(27)24-17-32-31(36-28(24)40(23)21-8-6-7-9-21)35-22-11-10-19(16-25(22)44-4)29(41)34-20-12-14-37(2)15-13-20/h10-11,16-18,20-21,23,43H,5-9,12-15H2,1-4H3,(H,34,41)(H,32,35,36)/t23-/m1/s1 RBFXWJWEHFNLDF-HSZRJFAPSA-N 50232587 CHEMBL4093737 Serine/threonine-protein kinase PLK1 Homo sapiens 7.0 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232587&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137653047 384226825 CHEMBL4093737 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687800 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C(O)=O)c12 InChI=1S/C30H38N8O4/c1-4-22-26-25(29(40)41)32-17-37(26)23-16-31-30(35-27(23)38(22)20-7-5-6-8-20)34-21-10-9-18(15-24(21)42-3)28(39)33-19-11-13-36(2)14-12-19/h9-10,15-17,19-20,22H,4-8,11-14H2,1-3H3,(H,33,39)(H,40,41)(H,31,34,35)/t22-/m1/s1 CBNBACZYZVMFBW-JOCHJYFZSA-N 50232588 CHEMBL4094634 Serine/threonine-protein kinase PLK1 Homo sapiens 1.4 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232588&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137653084 384226826 CHEMBL4094634 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687801 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(CO)c12 InChI=1S/C30H40N8O3/c1-4-24-27-23(17-39)32-18-37(27)25-16-31-30(35-28(25)38(24)21-7-5-6-8-21)34-22-10-9-19(15-26(22)41-3)29(40)33-20-11-13-36(2)14-12-20/h9-10,15-16,18,20-21,24,39H,4-8,11-14,17H2,1-3H3,(H,33,40)(H,31,34,35)/t24-/m1/s1 TYJHZOFBUGXDFG-XMMPIXPASA-N 50232590 CHEMBL4101459 Serine/threonine-protein kinase PLK1 Homo sapiens 2.2 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232590&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137659622 384226827 CHEMBL4101459 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687802 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnc(C#N)c12 InChI=1S/C28H35N9O2/c1-6-22-25-21(14-29)31-16-36(25)23-15-30-28(34-26(23)37(22)17(2)3)33-20-8-7-18(13-24(20)39-5)27(38)32-19-9-11-35(4)12-10-19/h7-8,13,15-17,19,22H,6,9-12H2,1-5H3,(H,32,38)(H,30,33,34)/t22-/m1/s1 GHMBRNIPQXNYFY-JOCHJYFZSA-N 50232591 CHEMBL4085987 Serine/threonine-protein kinase PLK1 Homo sapiens 8.6 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232591&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137642203 384226828 CHEMBL4085987 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50687803 CC[C@H]1N(C(C)C)c2nc(Nc3cc(F)c(cc3OC)C(=O)NC3CN(C)C3)ncc2-n2cnc(C#N)c12 InChI=1S/C26H30FN9O2/c1-6-20-23-19(9-28)30-13-35(23)21-10-29-26(33-24(21)36(20)14(2)3)32-18-8-17(27)16(7-22(18)38-5)25(37)31-15-11-34(4)12-15/h7-8,10,13-15,20H,6,11-12H2,1-5H3,(H,31,37)(H,29,32,33)/t20-/m1/s1 LZDAATYWWSHULX-HXUWFJFHSA-N 50232592 CHEMBL4088932 Serine/threonine-protein kinase PLK1 Homo sapiens 1.7 ChEMBL 10.1016/j.bmcl.2016.10.009 10.7270/Q2K939RQ 28169164 Kiryanov, A; Natala, S; Jones, B; McBride, C; Feher, V; Lam, B; Liu, Y; Honda, K; Uchiyama, N; Kawamoto, T; Hikichi, Y; Zhang, L; Hosfield, D; Skene, R; Zou, H; Stafford, J; Cao, X; Ichikawa, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232592&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137642104 384226829 CHEMBL4088932 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50756932 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1021/acs.jmedchem.7b00996 10.7270/Q26112G9 28792760 Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Moffitt Cancer Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50756933 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase PLK1 Homo sapiens 2.2 ChEMBL 10.1021/acs.jmedchem.7b00996 10.7270/Q26112G9 28792760 Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Moffitt Cancer Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50756934 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens <100 ChEMBL 10.1021/acs.jmedchem.7b00996 10.7270/Q26112G9 28792760 Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Moffitt Cancer Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50756935 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase PLK1 Homo sapiens <100 ChEMBL 10.1021/acs.jmedchem.7b00996 10.7270/Q26112G9 28792760 Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Moffitt Cancer Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50756955 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1 InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31) BKWJAKQVGHWELA-UHFFFAOYSA-N 50240826 AZD-1775::MK-1775::US11124518, Example AZD1775::US11248006, Compound AZD1775::US11479555, Example AZD1775 Serine/threonine-protein kinase PLK1 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.7b00996 10.7270/Q26112G9 28792760 Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Moffitt Cancer Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 8X7 5VDK,5VD0,5V5Y,8BJT 24856436 386401532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50756963 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase PLK1 Homo sapiens <100 ChEMBL 10.1021/acs.jmedchem.7b00996 10.7270/Q26112G9 28792760 Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Moffitt Cancer Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50756964 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens <100 ChEMBL 10.1021/acs.jmedchem.7b00996 10.7270/Q26112G9 28792760 Zhu, JY; Cuellar, RA; Berndt, N; Lee, HE; Olesen, SH; Martin, MP; Jensen, JT; Georg, GI; Schönbrunn, E Moffitt Cancer Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 705916 Clc1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1 InChI=1S/C20H15ClN4/c21-20-24-17-11-6-10-16(14-7-2-1-3-8-14)18(17)19(25-20)23-13-15-9-4-5-12-22-15/h1-12H,13H2,(H,23,24,25) JSYVMXAHYRRFOQ-UHFFFAOYSA-N 357015 US10214511, Example 19::US10676460, Example 19 Serine/threonine-protein kinase PLK1 Homo sapiens 50000 US Patent 10.7270/Q29Z975M aid1797663 US10214511 Lloyd, J; Finlay, H; Gunaga, P; Banerjee, A; Adisechan, A Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=357015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=357015&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 86670613 386396597 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50893713 Nc1ncnc2n(C[C@H]3CCCN3S(=O)(=O)C=C)cc(-c3ccc4OCOc4c3)c12 InChI=1S/C20H21N5O4S/c1-2-30(26,27)25-7-3-4-14(25)9-24-10-15(18-19(21)22-11-23-20(18)24)13-5-6-16-17(8-13)29-12-28-16/h2,5-6,8,10-11,14H,1,3-4,7,9,12H2,(H2,21,22,23)/t14-/m1/s1 OSAWFUCUZJNEID-CQSZACIVSA-N 50269615 CHEMBL4095253 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2017.07.009 10.7270/Q2WW7M50 28734581 He, L; Li, D; Zhang, C; Bai, P; Chen, L Sichuan University and Collaborative Innovation Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50269615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50269615&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137652864 404961580 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50830843 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1021/acs.jmedchem.6b01761 10.7270/Q27P91VQ 28195723 Liu, Z; Wang, P; Chen, H; Wold, EA; Tian, B; Brasier, AR; Zhou, J University of Texas Medical Branch http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831152 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C46H66FN8O12P/c1-29(2)24-36(51-46(62)39-20-15-23-55(39)31(4)57)43(59)50-37(44(60)52-38(27-56)45(61)53-41(42(48)58)30(3)67-68(63,64)65)25-32-26-49-28-54(32)22-13-8-6-5-7-12-18-34-35(47)19-14-21-40(34)66-33-16-10-9-11-17-33/h9-11,14,16-17,19,21,26,28-30,36-39,41,56H,5-8,12-13,15,18,20,22-25,27H2,1-4H3,(H2,48,58)(H,50,59)(H,51,62)(H,52,60)(H,53,61)(H2,63,64,65)/t30-,36+,37+,38+,39+,41+/m1/s1 XDRHCUWKZRZSEP-CQKJNDIKSA-N 50194933 CHEMBL3956625 Serine/threonine-protein kinase PLK1 Homo sapiens 6.6 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194933&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134143682 375977039 CHEMBL3956625 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831154 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 5.0 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831155 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 UIYQCJDQBRUFEV-FALOATQWSA-N 50403017 CHEMBL2207846 Serine/threonine-protein kinase PLK1 Homo sapiens >300 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49873221 163352041 CHEMBL2207846 ZINC95564030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831156 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1cccc(O)c1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C46H66FN8O13P/c1-28(2)22-36(51-46(63)39-18-13-21-55(39)30(4)57)43(60)50-37(44(61)52-38(26-56)45(62)53-41(42(48)59)29(3)68-69(64,65)66)23-31-25-49-27-54(31)20-10-8-6-5-7-9-16-34-35(47)17-12-19-40(34)67-33-15-11-14-32(58)24-33/h11-12,14-15,17,19,24-25,27-29,36-39,41,56,58H,5-10,13,16,18,20-23,26H2,1-4H3,(H2,48,59)(H,50,60)(H,51,63)(H,52,61)(H,53,62)(H2,64,65,66)/t29-,36+,37+,38+,39+,41+/m1/s1 SHZJITZSGHNGAS-USJNNXEMSA-N 50260121 CHEMBL4068949 Serine/threonine-protein kinase PLK1 Homo sapiens 188 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137632541 404340006 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831179 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccc(CCO)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C42H67N8O12P/c1-27(2)22-33(46-42(58)36-13-11-20-50(36)29(4)53)39(55)45-34(40(56)47-35(25-52)41(57)48-37(38(43)54)28(3)62-63(59,60)61)23-32-24-44-26-49(32)19-10-8-6-5-7-9-12-30-14-16-31(17-15-30)18-21-51/h14-17,24,26-28,33-37,51-52H,5-13,18-23,25H2,1-4H3,(H2,43,54)(H,45,55)(H,46,58)(H,47,56)(H,48,57)(H2,59,60,61)/t28-,33+,34+,35+,36+,37+/m1/s1 KSMYGTHXVJXRTI-UONILZFISA-N 50260122 CHEMBL4092848 Serine/threonine-protein kinase PLK1 Homo sapiens 218 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260122&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137652774 404340007 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831292 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1cccc(OCc2ccccc2)c1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C53H72FN8O13P/c1-34(2)27-43(58-53(69)46-23-16-26-62(46)36(4)64)50(66)57-44(51(67)59-45(31-63)52(68)60-48(49(55)65)35(3)75-76(70,71)72)28-38-30-56-33-61(38)25-13-8-6-5-7-12-21-41-42(54)22-15-24-47(41)74-40-20-14-19-39(29-40)73-32-37-17-10-9-11-18-37/h9-11,14-15,17-20,22,24,29-30,33-35,43-46,48,63H,5-8,12-13,16,21,23,25-28,31-32H2,1-4H3,(H2,55,65)(H,57,66)(H,58,69)(H,59,67)(H,60,68)(H2,70,71,72)/t35-,43+,44+,45+,46+,48+/m1/s1 STDVQZAYBMZKHW-SMKGIDQESA-N 50260123 CHEMBL4080819 Serine/threonine-protein kinase PLK1 Homo sapiens 862 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260123&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137648535 404340008 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831293 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccc(CCOCc2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C49H73N8O12P/c1-33(2)27-40(53-49(64)43-18-14-25-57(43)35(4)59)46(61)52-41(47(62)54-42(30-58)48(63)55-44(45(50)60)34(3)69-70(65,66)67)28-39-29-51-32-56(39)24-13-8-6-5-7-10-15-36-19-21-37(22-20-36)23-26-68-31-38-16-11-9-12-17-38/h9,11-12,16-17,19-22,29,32-34,40-44,58H,5-8,10,13-15,18,23-28,30-31H2,1-4H3,(H2,50,60)(H,52,61)(H,53,64)(H,54,62)(H,55,63)(H2,65,66,67)/t34-,40+,41+,42+,43+,44+/m1/s1 WQQABBZFVHSXMU-FWZUBCPGSA-N 50260124 CHEMBL4065187 Serine/threonine-protein kinase PLK1 Homo sapiens 152 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260124&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137632392 404340009 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50952767 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C78H114N21O29P/c1-10-37(4)61(74(118)90-51(29-44-17-21-47(103)22-18-44)68(112)84-38(5)65(109)87-49(64(81)108)31-59(80)105)94-66(110)39(6)85-76(120)63(41(8)128-129(125,126)127)96-72(116)55(34-100)93-71(115)53(30-45-33-82-35-83-45)88-69(113)50(27-36(2)3)89-73(117)56-13-11-25-97(56)78(122)57-14-12-26-98(57)77(121)54(32-60(106)107)92-70(114)52(28-43-15-19-46(20-16-43)99(123)124)91-75(119)62(40(7)101)95-67(111)48(86-42(9)102)23-24-58(79)104/h15-22,33,35-41,48-57,61-63,100-101,103H,10-14,23-32,34H2,1-9H3,(H2,79,104)(H2,80,105)(H2,81,108)(H,82,83)(H,84,112)(H,85,120)(H,86,102)(H,87,109)(H,88,113)(H,89,117)(H,90,118)(H,91,119)(H,92,114)(H,93,115)(H,94,110)(H,95,111)(H,96,116)(H,106,107)(H2,125,126,127)/t37-,38-,39-,40+,41+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,61-,62-,63-/m0/s1 CVQUPYTWQBPRPT-LUNNINKWSA-N 50274494 CHEMBL4128878 Serine/threonine-protein kinase PLK1 Homo sapiens 70 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274494&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145962002 405256924 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50952775 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C74H105Cl2N19O22/c1-9-35(4)59(71(114)89-49(26-40-14-17-43(99)18-15-40)65(108)82-36(5)62(105)85-47(61(79)104)29-57(78)101)92-63(106)37(6)83-72(115)60(38(7)97)93-69(112)53(32-96)91-68(111)51(28-42-31-80-33-81-42)87-66(109)48(24-34(2)3)88-70(113)54-12-10-22-94(54)74(117)55-13-11-23-95(55)73(116)52(30-58(102)103)90-67(110)50(27-41-16-19-44(75)45(76)25-41)86-64(107)46(84-39(8)98)20-21-56(77)100/h14-19,25,31,33-38,46-55,59-60,96-97,99H,9-13,20-24,26-30,32H2,1-8H3,(H2,77,100)(H2,78,101)(H2,79,104)(H,80,81)(H,82,108)(H,83,115)(H,84,98)(H,85,105)(H,86,107)(H,87,109)(H,88,113)(H,89,114)(H,90,110)(H,91,111)(H,92,106)(H,93,112)(H,102,103)/t35-,36-,37-,38+,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-,60-/m0/s1 MTBQLZXPNQZSFF-PVSBNZRSSA-N 50274495 CHEMBL4126401 Serine/threonine-protein kinase PLK1 Homo sapiens 66 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274495&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145961681 405256925 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50953132 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C69H100N17O23P/c1-9-35(4)55(66(102)80-47(27-41-19-21-43(89)22-20-41)60(96)74-36(5)58(94)77-44(57(71)93)29-53(70)90)83-59(95)37(6)75-67(103)56(38(7)109-110(106,107)108)84-64(100)50(32-87)82-63(99)48(28-42-31-72-33-73-42)78-61(97)45(25-34(2)3)79-65(101)51-17-13-23-85(51)69(105)52-18-14-24-86(52)68(104)49(30-54(91)92)81-62(98)46(76-39(8)88)26-40-15-11-10-12-16-40/h10-12,15-16,19-22,31,33-38,44-52,55-56,87,89H,9,13-14,17-18,23-30,32H2,1-8H3,(H2,70,90)(H2,71,93)(H,72,73)(H,74,96)(H,75,103)(H,76,88)(H,77,94)(H,78,97)(H,79,101)(H,80,102)(H,81,98)(H,82,99)(H,83,95)(H,84,100)(H,91,92)(H2,106,107,108)/t35-,36-,37-,38+,44-,45-,46-,47-,48-,49-,50-,51-,52-,55-,56-/m0/s1 ZEYJNZQOPNCYCS-ZVQFBMPOSA-N 50274498 CHEMBL4127365 Serine/threonine-protein kinase PLK1 Homo sapiens 283 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274498&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145961079 405256928 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50953188 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C78H114ClN20O27P/c1-10-37(4)61(74(118)91-51(29-44-17-21-47(103)22-18-44)68(112)85-38(5)65(109)88-49(64(82)108)31-59(81)105)95-66(110)39(6)86-76(120)63(41(8)126-127(123,124)125)97-72(116)55(34-100)94-71(115)53(30-46-33-83-35-84-46)89-69(113)50(27-36(2)3)90-73(117)56-13-11-25-98(56)78(122)57-14-12-26-99(57)77(121)54(32-60(106)107)93-70(114)52(28-43-15-19-45(79)20-16-43)92-75(119)62(40(7)101)96-67(111)48(87-42(9)102)23-24-58(80)104/h15-22,33,35-41,48-57,61-63,100-101,103H,10-14,23-32,34H2,1-9H3,(H2,80,104)(H2,81,105)(H2,82,108)(H,83,84)(H,85,112)(H,86,120)(H,87,102)(H,88,109)(H,89,113)(H,90,117)(H,91,118)(H,92,119)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,116)(H,106,107)(H2,123,124,125)/t37-,38-,39-,40+,41+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,61-,62-,63-/m0/s1 VNGDFHCHTLGXAT-LUNNINKWSA-N 50274499 CHEMBL4130094 Serine/threonine-protein kinase PLK1 Homo sapiens 90 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274499&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145960768 405256929 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50953189 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C78H114FN20O27P/c1-10-37(4)61(74(118)91-51(29-44-17-21-47(103)22-18-44)68(112)85-38(5)65(109)88-49(64(82)108)31-59(81)105)95-66(110)39(6)86-76(120)63(41(8)126-127(123,124)125)97-72(116)55(34-100)94-71(115)53(30-46-33-83-35-84-46)89-69(113)50(27-36(2)3)90-73(117)56-13-11-25-98(56)78(122)57-14-12-26-99(57)77(121)54(32-60(106)107)93-70(114)52(28-43-15-19-45(79)20-16-43)92-75(119)62(40(7)101)96-67(111)48(87-42(9)102)23-24-58(80)104/h15-22,33,35-41,48-57,61-63,100-101,103H,10-14,23-32,34H2,1-9H3,(H2,80,104)(H2,81,105)(H2,82,108)(H,83,84)(H,85,112)(H,86,120)(H,87,102)(H,88,109)(H,89,113)(H,90,117)(H,91,118)(H,92,119)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,116)(H,106,107)(H2,123,124,125)/t37-,38-,39-,40+,41+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,61-,62-,63-/m0/s1 ATLCUJLPLLGZMV-LUNNINKWSA-N 50274500 CHEMBL4126831 Serine/threonine-protein kinase PLK1 Homo sapiens 74 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145961248 405256930 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50953190 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C79H117N20O28P/c1-11-38(4)62(75(118)91-52(29-44-16-20-47(103)21-17-44)69(112)85-39(5)66(109)88-50(65(82)108)32-60(81)105)95-67(110)40(6)86-77(120)64(42(8)127-128(123,124)125)97-73(116)56(35-100)94-72(115)54(31-46-34-83-36-84-46)89-70(113)51(28-37(2)3)90-74(117)57-14-12-26-98(57)79(122)58-15-13-27-99(58)78(121)55(33-61(106)107)93-71(114)53(30-45-18-22-48(126-10)23-19-45)92-76(119)63(41(7)101)96-68(111)49(87-43(9)102)24-25-59(80)104/h16-23,34,36-42,49-58,62-64,100-101,103H,11-15,24-33,35H2,1-10H3,(H2,80,104)(H2,81,105)(H2,82,108)(H,83,84)(H,85,112)(H,86,120)(H,87,102)(H,88,109)(H,89,113)(H,90,117)(H,91,118)(H,92,119)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,116)(H,106,107)(H2,123,124,125)/t38-,39-,40-,41+,42+,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,62-,63-,64-/m0/s1 PUNYDJZGIIMRPF-WPUQGRPTSA-N 50274516 CHEMBL4130239 Serine/threonine-protein kinase PLK1 Homo sapiens 2109 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274516&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145962909 405256931 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50953191 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(C)=O)[C@@H](C)O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C78H113Cl2N20O27P/c1-10-36(4)61(74(119)92-51(27-42-15-18-45(104)19-16-42)68(113)86-37(5)65(110)89-49(64(83)109)30-59(82)106)96-66(111)38(6)87-76(121)63(40(8)127-128(124,125)126)98-72(117)55(33-101)95-71(116)53(29-44-32-84-34-85-44)90-69(114)50(25-35(2)3)91-73(118)56-13-11-23-99(56)78(123)57-14-12-24-100(57)77(122)54(31-60(107)108)94-70(115)52(28-43-17-20-46(79)47(80)26-43)93-75(120)62(39(7)102)97-67(112)48(88-41(9)103)21-22-58(81)105/h15-20,26,32,34-40,48-57,61-63,101-102,104H,10-14,21-25,27-31,33H2,1-9H3,(H2,81,105)(H2,82,106)(H2,83,109)(H,84,85)(H,86,113)(H,87,121)(H,88,103)(H,89,110)(H,90,114)(H,91,118)(H,92,119)(H,93,120)(H,94,115)(H,95,116)(H,96,111)(H,97,112)(H,98,117)(H,107,108)(H2,124,125,126)/t36-,37-,38-,39+,40+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,61-,62-,63-/m0/s1 FDOIWTRDHIVKQM-LSAAGVNISA-N 50274497 CHEMBL4127627 Serine/threonine-protein kinase PLK1 Homo sapiens 39 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274497&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145960661 405256927 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50953192 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C73H105Cl2N18O25P/c1-10-34(4)57(69(110)86-48(25-40-15-18-43(97)19-16-40)63(104)80-35(5)61(102)83-46(60(77)101)28-55(76)98)90-62(103)36(6)81-71(112)59(38(8)118-119(115,116)117)91-67(108)52(31-94)89-66(107)50(27-42-30-78-32-79-42)84-64(105)47(23-33(2)3)85-68(109)53-13-11-21-92(53)73(114)54-14-12-22-93(54)72(113)51(29-56(99)100)88-65(106)49(26-41-17-20-44(74)45(75)24-41)87-70(111)58(37(7)95)82-39(9)96/h15-20,24,30,32-38,46-54,57-59,94-95,97H,10-14,21-23,25-29,31H2,1-9H3,(H2,76,98)(H2,77,101)(H,78,79)(H,80,104)(H,81,112)(H,82,96)(H,83,102)(H,84,105)(H,85,109)(H,86,110)(H,87,111)(H,88,106)(H,89,107)(H,90,103)(H,91,108)(H,99,100)(H2,115,116,117)/t34-,35-,36-,37+,38+,46-,47-,48-,49-,50-,51-,52-,53-,54-,57-,58-,59-/m0/s1 JVXYASQZZSNBNY-AFDDGZHISA-N 50274517 CHEMBL4129028 Serine/threonine-protein kinase PLK1 Homo sapiens 75 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274517&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145961137 405256932 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50953193 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(C)=O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(N)=O InChI=1S/C69H98Cl2N17O23P/c1-9-33(4)55(66(104)82-47(24-38-14-17-41(91)18-15-38)60(98)76-34(5)58(96)79-44(57(73)95)27-53(72)92)85-59(97)35(6)77-67(105)56(36(7)111-112(108,109)110)86-64(102)50(30-89)84-63(101)48(26-40-29-74-31-75-40)80-61(99)45(22-32(2)3)81-65(103)51-12-10-20-87(51)69(107)52-13-11-21-88(52)68(106)49(28-54(93)94)83-62(100)46(78-37(8)90)25-39-16-19-42(70)43(71)23-39/h14-19,23,29,31-36,44-52,55-56,89,91H,9-13,20-22,24-28,30H2,1-8H3,(H2,72,92)(H2,73,95)(H,74,75)(H,76,98)(H,77,105)(H,78,90)(H,79,96)(H,80,99)(H,81,103)(H,82,104)(H,83,100)(H,84,101)(H,85,97)(H,86,102)(H,93,94)(H2,108,109,110)/t33-,34-,35-,36+,44-,45-,46-,47-,48-,49-,50-,51-,52-,55-,56-/m0/s1 DYAVJUMLONUWEK-LJVLLLNMSA-N 50274496 CHEMBL4127785 Serine/threonine-protein kinase PLK1 Homo sapiens 78 ChEMBL 10.1016/j.bmc.2018.05.014 10.7270/Q2CC1364 29807699 Lin, TY; Min, HP; Jiang, C; Niu, MM; Yan, F; Xu, LL; Di, B China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274496&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145963032 405256926 C03874 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096595 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C(C)C)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C25H35N7O3/c1-15(2)32-16(3)24(34)31(5)20-14-26-25(29-22(20)32)28-19-8-7-17(13-21(19)35-6)23(33)27-18-9-11-30(4)12-10-18/h7-8,13-16,18H,9-12H2,1-6H3,(H,27,33)(H,26,28,29)/t16-/m1/s1 XWNHXTVCPNRSTM-MRXNPFEDSA-N 50458964 CHEMBL4206052 Serine/threonine-protein kinase PLK1 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458964&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145967512 433926229 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096596 CC[C@@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m0/s1 XQVVPGYIWAGRNI-QFIPXVFZSA-N 50112336 CHEMBL3609305 Serine/threonine-protein kinase PLK1 Homo sapiens 33 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112336&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 86295201 319493551 CHEMBL3609305 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096523 CCC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C29H41N7O3/c1-5-8-23-28(38)35(3)24-18-30-29(33-26(24)36(23)21-9-6-7-10-21)32-22-12-11-19(17-25(22)39-4)27(37)31-20-13-15-34(2)16-14-20/h11-12,17-18,20-21,23H,5-10,13-16H2,1-4H3,(H,31,37)(H,30,32,33)/t23-/m1/s1 ZUJOXCIHOKDDRE-HSZRJFAPSA-N 50458951 CHEMBL4206171 Serine/threonine-protein kinase PLK1 Homo sapiens 9.9 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458951&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975649 433926216 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096528 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)NCCc1ccccc1 InChI=1S/C29H34N6O3/c1-19-28(37)34(2)24-18-31-29(33-26(24)35(19)22-11-7-8-12-22)32-23-14-13-21(17-25(23)38-3)27(36)30-16-15-20-9-5-4-6-10-20/h4-6,9-10,13-14,17-19,22H,7-8,11-12,15-16H2,1-3H3,(H,30,36)(H,31,32,33)/t19-/m1/s1 ITDUQSWFIDASGI-LJQANCHMSA-N 50458952 CHEMBL4203571 Serine/threonine-protein kinase PLK1 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458952&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145978238 433926217 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096530 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2NC1=O InChI=1S/C25H35N7O3/c1-6-20-24(34)28-19-14-26-25(30-22(19)32(20)15(2)3)29-18-8-7-16(13-21(18)35-5)23(33)27-17-9-11-31(4)12-10-17/h7-8,13-15,17,20H,6,9-12H2,1-5H3,(H,27,33)(H,28,34)(H,26,29,30)/t20-/m1/s1 ORNXQDLRPQLTAL-HXUWFJFHSA-N 50458953 CHEMBL4218106 Serine/threonine-protein kinase PLK1 Homo sapiens 2620 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458953&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145970287 433926218 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096536 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@H](C)N(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C27H37N7O3/c1-17-26(36)33(3)22-16-28-27(31-24(22)34(17)20-7-5-6-8-20)30-21-10-9-18(15-23(21)37-4)25(35)29-19-11-13-32(2)14-12-19/h9-10,15-17,19-20H,5-8,11-14H2,1-4H3,(H,29,35)(H,28,30,31)/t17-/m0/s1 DYQPKOGFUIEBMS-KRWDZBQOSA-N 50458960 CHEMBL4216875 Serine/threonine-protein kinase PLK1 Homo sapiens 8.7 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458960&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145972845 433926225 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096537 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)NC1CCCCC1 InChI=1S/C27H36N6O3/c1-17-26(35)32(2)22-16-28-27(31-24(22)33(17)20-11-7-8-12-20)30-21-14-13-18(15-23(21)36-3)25(34)29-19-9-5-4-6-10-19/h13-17,19-20H,4-12H2,1-3H3,(H,29,34)(H,28,30,31)/t17-/m1/s1 IRCDNPBWELYZBD-QGZVFWFLSA-N 50458961 CHEMBL4210414 Serine/threonine-protein kinase PLK1 Homo sapiens 160 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458961&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145965219 433926226 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096538 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)NC1CCNCC1 InChI=1S/C26H35N7O3/c1-16-25(35)32(2)21-15-28-26(31-23(21)33(16)19-6-4-5-7-19)30-20-9-8-17(14-22(20)36-3)24(34)29-18-10-12-27-13-11-18/h8-9,14-16,18-19,27H,4-7,10-13H2,1-3H3,(H,29,34)(H,28,30,31)/t16-/m1/s1 YGQSAYAQCWLSAL-MRXNPFEDSA-N 50458962 CHEMBL4213276 Serine/threonine-protein kinase PLK1 Homo sapiens 9.0 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458962&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11283298 433926227 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096545 CC[C@H]1N(C2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2NC1=O InChI=1S/C28H39N7O3/c1-4-23-27(37)31-22-17-29-28(33-25(22)35(23)20-8-6-5-7-9-20)32-21-11-10-18(16-24(21)38-3)26(36)30-19-12-14-34(2)15-13-19/h10-11,16-17,19-20,23H,4-9,12-15H2,1-3H3,(H,30,36)(H,31,37)(H,29,32,33)/t23-/m1/s1 ZHKZODVLISQHOS-HSZRJFAPSA-N 50458959 CHEMBL4214823 Serine/threonine-protein kinase PLK1 Homo sapiens 37 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458959&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145972286 433926224 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096549 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)N1CCCCC1 InChI=1S/C26H34N6O3/c1-17-24(33)30(2)21-16-27-26(29-23(21)32(17)19-9-5-6-10-19)28-20-12-11-18(15-22(20)35-3)25(34)31-13-7-4-8-14-31/h11-12,15-17,19H,4-10,13-14H2,1-3H3,(H,27,28,29)/t17-/m1/s1 CFTIJALKSHXVNU-QGZVFWFLSA-N 50458956 CHEMBL4202678 Serine/threonine-protein kinase PLK1 Homo sapiens 95 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458956&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145977980 433926221 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096552 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C26H37N7O3/c1-7-20-25(35)32(5)21-15-27-26(30-23(21)33(20)16(2)3)29-19-9-8-17(14-22(19)36-6)24(34)28-18-10-12-31(4)13-11-18/h8-9,14-16,18,20H,7,10-13H2,1-6H3,(H,28,34)(H,27,29,30)/t20-/m1/s1 UMRCTLFOWLGNGP-HXUWFJFHSA-N 50458969 CHEMBL4207165 Serine/threonine-protein kinase PLK1 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458969&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975937 433926234 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096555 C[C@@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC3CCCC3)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C31H43N7O3/c1-20-30(40)37(3)26-19-32-31(35-28(26)38(20)23-8-4-5-9-23)34-25-13-12-21(18-27(25)41-24-10-6-7-11-24)29(39)33-22-14-16-36(2)17-15-22/h12-13,18-20,22-24H,4-11,14-17H2,1-3H3,(H,33,39)(H,32,34,35)/t20-/m0/s1 HTPNGOWITIWAHM-FQEVSTJZSA-N 50458970 CHEMBL4206381 Serine/threonine-protein kinase PLK1 Homo sapiens 127 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458970&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145976646 433926235 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096558 COc1cc(ccc1Nc1ncc2N(C)C(=O)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C26H35N7O3/c1-31-12-10-18(11-13-31)28-25(35)17-8-9-20(22(14-17)36-3)29-26-27-15-21-24(30-26)33(16-23(34)32(21)2)19-6-4-5-7-19/h8-9,14-15,18-19H,4-7,10-13,16H2,1-3H3,(H,28,35)(H,27,29,30) BWKCRAURLKJCJQ-UHFFFAOYSA-N 50112335 CHEMBL3609304 Serine/threonine-protein kinase PLK1 Homo sapiens 54 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112335&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 122187519 319493550 CHEMBL3609304 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096559 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C27H37N7O3/c1-17-26(36)33(3)22-16-28-27(31-24(22)34(17)20-7-5-6-8-20)30-21-10-9-18(15-23(21)37-4)25(35)29-19-11-13-32(2)14-12-19/h9-10,15-17,19-20H,5-8,11-14H2,1-4H3,(H,29,35)(H,28,30,31)/t17-/m1/s1 DYQPKOGFUIEBMS-QGZVFWFLSA-N 50458963 CHEMBL4209902 Serine/threonine-protein kinase PLK1 Homo sapiens 1.1 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458963&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11260691 433926228 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096560 CC[C@H]1N(C2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C29H41N7O3/c1-5-23-28(38)35(3)24-18-30-29(33-26(24)36(23)21-9-7-6-8-10-21)32-22-12-11-19(17-25(22)39-4)27(37)31-20-13-15-34(2)16-14-20/h11-12,17-18,20-21,23H,5-10,13-16H2,1-4H3,(H,31,37)(H,30,32,33)/t23-/m1/s1 LCZUOXPDOGJHTF-HSZRJFAPSA-N 50458971 CHEMBL4215729 Serine/threonine-protein kinase PLK1 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458971&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145972096 433926236 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096561 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096575 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC(C)C)N(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C30H43N7O3/c1-19(2)16-24-29(39)36(4)25-18-31-30(34-27(25)37(24)22-8-6-7-9-22)33-23-11-10-20(17-26(23)40-5)28(38)32-21-12-14-35(3)15-13-21/h10-11,17-19,21-22,24H,6-9,12-16H2,1-5H3,(H,32,38)(H,31,33,34)/t24-/m1/s1 YMVZNORRCJILSK-XMMPIXPASA-N 50458958 CHEMBL4215910 Serine/threonine-protein kinase PLK1 Homo sapiens 78 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458958&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 124098192 433926223 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096576 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C28H39N7O3/c1-18-27(37)34(3)23-17-29-28(32-25(23)35(18)21-8-6-5-7-9-21)31-22-11-10-19(16-24(22)38-4)26(36)30-20-12-14-33(2)15-13-20/h10-11,16-18,20-21H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t18-/m1/s1 IRXGEPQYGSUCML-GOSISDBHSA-N 50458967 CHEMBL4202820 Serine/threonine-protein kinase PLK1 Homo sapiens 8.6 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458967&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145976012 433926232 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096577 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC(C)C)N(C3CCOCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C30H43N7O4/c1-19(2)16-24-29(39)36(4)25-18-31-30(34-27(25)37(24)22-10-14-41-15-11-22)33-23-7-6-20(17-26(23)40-5)28(38)32-21-8-12-35(3)13-9-21/h6-7,17-19,21-22,24H,8-16H2,1-5H3,(H,32,38)(H,31,33,34)/t24-/m1/s1 SDTDGTQRZUJKKU-XMMPIXPASA-N 50458954 CHEMBL4207347 Serine/threonine-protein kinase PLK1 Homo sapiens 322 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458954&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975701 433926219 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096578 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC(C)C)N(C(C)C)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C28H41N7O3/c1-17(2)14-22-27(37)34(6)23-16-29-28(32-25(23)35(22)18(3)4)31-21-9-8-19(15-24(21)38-7)26(36)30-20-10-12-33(5)13-11-20/h8-9,15-18,20,22H,10-14H2,1-7H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 ZQUZSYJDRGJSED-JOCHJYFZSA-N 50458957 CHEMBL4212237 Serine/threonine-protein kinase PLK1 Homo sapiens 218 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458957&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145963915 433926222 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096579 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)NC1=CCN(C)C=C1 InChI=1S/C27H33N7O3/c1-17-26(36)33(3)22-16-28-27(31-24(22)34(17)20-7-5-6-8-20)30-21-10-9-18(15-23(21)37-4)25(35)29-19-11-13-32(2)14-12-19/h9-13,15-17,20H,5-8,14H2,1-4H3,(H,29,35)(H,28,30,31)/t17-/m1/s1 LBXYVUXGPFEVSI-QGZVFWFLSA-N 50458968 CHEMBL4216442 Serine/threonine-protein kinase PLK1 Homo sapiens 8.4 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458968&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145972360 433926233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096580 COc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](C)N(C3CCCC3)c2n1)C(=O)NCCN(C)C InChI=1S/C25H35N7O3/c1-16-24(34)31(4)20-15-27-25(29-22(20)32(16)18-8-6-7-9-18)28-19-11-10-17(14-21(19)35-5)23(33)26-12-13-30(2)3/h10-11,14-16,18H,6-9,12-13H2,1-5H3,(H,26,33)(H,27,28,29)/t16-/m1/s1 VBDIOKSSYUZONA-MRXNPFEDSA-N 50458965 CHEMBL4210571 Serine/threonine-protein kinase PLK1 Homo sapiens 21 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458965&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145964543 433926230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096581 COC(=O)c1ccc(Nc2ncc3N(C)C(=O)[C@@H](C)N(C4CCCC4)c3n2)c(OC2CCCC2)c1 InChI=1S/C26H33N5O4/c1-16-24(32)30(2)21-15-27-26(29-23(21)31(16)18-8-4-5-9-18)28-20-13-12-17(25(33)34-3)14-22(20)35-19-10-6-7-11-19/h12-16,18-19H,4-11H2,1-3H3,(H,27,28,29)/t16-/m1/s1 QAXOLKUTJAQVHO-MRXNPFEDSA-N 50458973 CHEMBL4212346 Serine/threonine-protein kinase PLK1 Homo sapiens 457 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458973&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145964393 433926238 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096582 C[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC3CCCC3)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C31H43N7O3/c1-20-30(40)37(3)26-19-32-31(35-28(26)38(20)23-8-4-5-9-23)34-25-13-12-21(18-27(25)41-24-10-6-7-11-24)29(39)33-22-14-16-36(2)17-15-22/h12-13,18-20,22-24H,4-11,14-17H2,1-3H3,(H,33,39)(H,32,34,35)/t20-/m1/s1 HTPNGOWITIWAHM-HXUWFJFHSA-N 50458966 CHEMBL4207437 Serine/threonine-protein kinase PLK1 Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458966&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975703 433926231 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51096583 CCC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC3CCCC3)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C33H47N7O3/c1-4-9-27-32(42)39(3)28-21-34-33(37-30(28)40(27)24-10-5-6-11-24)36-26-15-14-22(20-29(26)43-25-12-7-8-13-25)31(41)35-23-16-18-38(2)19-17-23/h14-15,20-21,23-25,27H,4-13,16-19H2,1-3H3,(H,35,41)(H,34,36,37)/t27-/m1/s1 QIWKCZYPLMKZJX-HHHXNRCGSA-N 50458955 CHEMBL4209192 Serine/threonine-protein kinase PLK1 Homo sapiens 47 ChEMBL 10.1021/acs.jmedchem.8b00765 10.7270/Q2MP55WQ 30125504 Liu, S; Yosief, HO; Dai, L; Huang, H; Dhawan, G; Zhang, X; Muthengi, AM; Roberts, J; Buckley, DL; Perry, JA; Wu, L; Bradner, JE; Qi, J; Zhang, W University of Massachusetts-Boston http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50458955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50458955&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145966579 433926220 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112889 COc1ccccc1-c1ccnc(Nc2cccc(Cn3cnc4ccccc34)c2)n1 InChI=1S/C25H21N5O/c1-31-24-12-5-2-9-20(24)21-13-14-26-25(29-21)28-19-8-6-7-18(15-19)16-30-17-27-22-10-3-4-11-23(22)30/h2-15,17H,16H2,1H3,(H,26,28,29) ZNYWIWXWOHYBON-UHFFFAOYSA-N 50454384 CHEMBL4205779 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454384&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975632 433922741 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112916 COc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20FN5O4S/c1-13-14(2)27-32-21(13)28-33(29,30)16-9-7-15(8-10-16)25-22-24-12-11-18(26-22)20-17(23)5-4-6-19(20)31-3/h4-12,28H,1-3H3,(H,24,25,26) CIKHZDKMTDPCLM-UHFFFAOYSA-N 50454411 CHEMBL4209151 Serine/threonine-protein kinase PLK1 Homo sapiens 12350 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454411&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145964931 433922768 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112917 COc1ccc(F)c(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H19F2N5O4S/c1-12-13(2)28-33-21(12)29-34(30,31)15-6-4-14(5-7-15)26-22-25-11-10-17(27-22)19-18(32-3)9-8-16(23)20(19)24/h4-11,29H,1-3H3,(H,25,26,27) FPPDWTSDSZADQO-UHFFFAOYSA-N 50454379 CHEMBL4205123 Serine/threonine-protein kinase PLK1 Homo sapiens 5910 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454379&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975607 433922736 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112918 CCOc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C23H22FN5O4S/c1-4-32-20-7-5-6-18(24)21(20)19-12-13-25-23(27-19)26-16-8-10-17(11-9-16)34(30,31)29-22-14(2)15(3)28-33-22/h5-13,29H,4H2,1-3H3,(H,25,26,27) BFSKFHZFACZLER-UHFFFAOYSA-N 50454392 CHEMBL4204526 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454392&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145977821 433922749 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112919 COc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H17FN6O3S2/c1-12-25-26-20(31-12)27-32(28,29)14-8-6-13(7-9-14)23-19-22-11-10-16(24-19)18-15(21)4-3-5-17(18)30-2/h3-11H,1-2H3,(H,26,27)(H,22,23,24) LRXZVWVFJCSXSV-UHFFFAOYSA-N 50454402 CHEMBL4209357 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454402&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145965423 433922759 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112920 COc1cccc(F)c1-c1ccnc(Nc2cccc(Cn3cnc4ccccc34)c2)n1 InChI=1S/C25H20FN5O/c1-32-23-11-5-8-19(26)24(23)21-12-13-27-25(30-21)29-18-7-4-6-17(14-18)15-31-16-28-20-9-2-3-10-22(20)31/h2-14,16H,15H2,1H3,(H,27,29,30) MDOPSPOMDXUNGM-UHFFFAOYSA-N 50454410 CHEMBL4212641 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454410&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145965313 433922767 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112926 COc1cccc(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)n1 InChI=1S/C20H16FN5O3S2/c1-29-17-4-2-3-15(21)18(17)16-9-10-22-19(25-16)24-13-5-7-14(8-6-13)31(27,28)26-20-23-11-12-30-20/h2-12H,1H3,(H,23,26)(H,22,24,25) BQRWVMGYVBRTGW-UHFFFAOYSA-N 50454399 CHEMBL4215419 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454399&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145973930 433922756 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112938 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2onc(C)c2C)n1 InChI=1S/C22H20FN5O4S/c1-13-14(2)27-32-21(13)28-33(29,30)17-7-5-16(6-8-17)25-22-24-11-10-19(26-22)18-9-4-15(23)12-20(18)31-3/h4-12,28H,1-3H3,(H,24,25,26) AJXDBLPSUPQKBJ-UHFFFAOYSA-N 50454396 CHEMBL4207754 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454396&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145976701 433922753 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112939 COc1cc(F)ccc1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2noc(C)c2C)n1 InChI=1S/C22H20FN5O4S/c1-13-14(2)32-27-21(13)28-33(29,30)17-7-5-16(6-8-17)25-22-24-11-10-19(26-22)18-9-4-15(23)12-20(18)31-3/h4-12H,1-3H3,(H,27,28)(H,24,25,26) PEFQLFPPRNGLJD-UHFFFAOYSA-N 50454453 CHEMBL4211020 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454453&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145964106 433922782 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51112946 COc1ccc(F)c(F)c1-c1ccnc(Nc2ccc(cc2)S(=O)(=O)Nc2nnc(C)s2)n1 InChI=1S/C20H16F2N6O3S2/c1-11-26-27-20(32-11)28-33(29,30)13-5-3-12(4-6-13)24-19-23-10-9-15(25-19)17-16(31-2)8-7-14(21)18(17)22/h3-10H,1-2H3,(H,27,28)(H,23,24,25) XWXGKRQCUJICNZ-UHFFFAOYSA-N 50454441 CHEMBL4217448 Serine/threonine-protein kinase PLK1 Homo sapiens >12500 ChEMBL 10.1016/j.bmcl.2018.01.002 10.7270/Q20867XN 29329658 Czudor, Z; Balogh, M; Bánhegyi, P; Boros, S; Breza, N; Dobos, J; Fábián, M; Horváth, Z; Illyés, E; Markó, P; Sipos, A; Szántai-Kis, C; Szokol, B; Őrfi, L Semmelweis University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50454441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50454441&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145972872 433922772 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001080 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NCC(C)C InChI=1S/C27H34N6O2/c1-5-21-26(35)31(4)23-16-29-27(30-24(23)33(21)20-8-6-7-9-20)32-13-12-18-14-19(10-11-22(18)32)25(34)28-15-17(2)3/h10-14,16-17,20-21H,5-9,15H2,1-4H3,(H,28,34)/t21-/m1/s1 MCJYLZXJWVLMLI-OAQYLSRUSA-N 50285588 CHEMBL4171224 Serine/threonine-protein kinase PLK1 Homo sapiens 122 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285588&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145950482 104127159 ZINC26494149 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001081 CCC1N(c2ccn(C)n2)c2nc(Nc3ccc(cc3)S(=O)(=O)NC)ncc2N(C)C1=O InChI=1S/C20H24N8O3S/c1-5-15-19(29)27(4)16-12-22-20(24-18(16)28(15)17-10-11-26(3)25-17)23-13-6-8-14(9-7-13)32(30,31)21-2/h6-12,15,21H,5H2,1-4H3,(H,22,23,24) XFHCCTMTQFFLCT-UHFFFAOYSA-N 50285548 CHEMBL4172511 Serine/threonine-protein kinase PLK1 Homo sapiens 742 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285548&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145951598 104127119 ZINC26480619 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001082 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)S(=O)(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C25H34N6O3S/c1-3-21-24(32)30(2)22-16-26-25(28-23(22)31(21)19-10-6-7-11-19)27-17-12-14-20(15-13-17)35(33,34)29-18-8-4-5-9-18/h12-16,18-19,21,29H,3-11H2,1-2H3,(H,26,27,28)/t21-/m1/s1 UZVJWQPORUUHRW-OAQYLSRUSA-N 50285581 CHEMBL4173620 Serine/threonine-protein kinase PLK1 Homo sapiens 52 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285581&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451381 104127152 ZINC26500233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001153 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 5.3 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001174 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NC InChI=1S/C24H28N6O2/c1-4-18-23(32)28(3)20-14-26-24(27-21(20)30(18)17-7-5-6-8-17)29-12-11-15-13-16(22(31)25-2)9-10-19(15)29/h9-14,17-18H,4-8H2,1-3H3,(H,25,31)/t18-/m1/s1 TWYRQXNMQMYEGC-GOSISDBHSA-N 50285580 CHEMBL4163892 Serine/threonine-protein kinase PLK1 Homo sapiens 94 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285580&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145958286 104127151 ZINC26495626 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001434 CCCCNS(=O)(=O)c1ccc(Nc2ncc3N(C)C(=O)C(CC)N(c4ccn(C)n4)c3n2)cc1 InChI=1S/C23H30N8O3S/c1-5-7-13-25-35(33,34)17-10-8-16(9-11-17)26-23-24-15-19-21(27-23)31(20-12-14-29(3)28-20)18(6-2)22(32)30(19)4/h8-12,14-15,18,25H,5-7,13H2,1-4H3,(H,24,26,27) HEVBIDCNQYUCRF-UHFFFAOYSA-N 50285578 CHEMBL4176689 Serine/threonine-protein kinase PLK1 Homo sapiens 462 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285578&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975479 104127149 ZINC26503008 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001854 CCC1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(F)ccc12 InChI=1S/C21H20FN7O/c1-4-15-20(30)27(3)17-12-23-21(24-19(17)29(15)18-8-9-26(2)25-18)28-10-7-13-11-14(22)5-6-16(13)28/h5-12,15H,4H2,1-3H3 PBCQZHURJOYTKB-UHFFFAOYSA-N 50285543 CHEMBL4167865 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285543&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145954798 104127114 ZINC26400975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51130122 CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) HIUHVDROHDSKTC-UHFFFAOYSA-N 50463479 CHEMBL4249925 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463479&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6U1 5KKS 11690457 433930744 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51130204 CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(cs3)-c3c[nH]c4ncccc34)c2)CC1 InChI=1S/C26H30N6O2S/c1-31-10-12-32(13-11-31)9-4-14-34-20-6-2-5-19(15-20)16-24(33)30-26-29-23(18-35-26)22-17-28-25-21(22)7-3-8-27-25/h2-3,5-8,15,17-18H,4,9-14,16H2,1H3,(H,27,28)(H,29,30,33) KWQRIWDMNAKJAF-UHFFFAOYSA-N 50463484 CHEMBL4248525 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463484&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6U2 5KKT 11705863 433930749 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51128171 O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 InChI=1S/C23H27N5O2S/c29-22(27-23-26-21(17-31-23)19-5-7-24-8-6-19)16-18-3-1-4-20(15-18)30-14-2-11-28-12-9-25-10-13-28/h1,3-8,15,17,25H,2,9-14,16H2,(H,26,27,29) XLMFBNMLEHYJGT-UHFFFAOYSA-N 50462709 CHEMBL4245507 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.06.043 10.7270/Q2XP77MH 29945794 Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J Vertex Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462709&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 60097495 433929974 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51128298 O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 InChI=1S/C24H28N4O2S/c29-23(28-24-27-22(17-31-24)20-8-12-26-13-9-20)16-19-3-1-5-21(15-19)30-14-2-4-18-6-10-25-11-7-18/h1,3,5,8-9,12-13,15,17-18,25H,2,4,6-7,10-11,14,16H2,(H,27,28,29) IMDMAPNWXDTADU-UHFFFAOYSA-N 50462710 CHEMBL4251324 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.06.043 10.7270/Q2XP77MH 29945794 Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J Vertex Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462710&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 65R 5HVU 60097413 433929975 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51133551 CCNc1cc(ccn1)-c1ccc(NC(=O)Nc2cccc(Cl)c2)cc1C(F)(F)F InChI=1S/C21H18ClF3N4O/c1-2-26-19-10-13(8-9-27-19)17-7-6-16(12-18(17)21(23,24)25)29-20(30)28-15-5-3-4-14(22)11-15/h3-12H,2H2,1H3,(H,26,27)(H2,28,29,30) BIIPWGFUTBPTNQ-UHFFFAOYSA-N 50464814 CHEMBL4281348 Serine/threonine-protein kinase PLK1 Homo sapiens 85 ChEMBL 10.1016/j.ejmech.2017.12.046 10.7270/Q2QF8WJK 29288948 Pan, Z; Chen, Y; Liu, J; Jiang, Q; Yang, S; Guo, L; He, G Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50464814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50464814&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145981755 433932079 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50999781 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(N)=O InChI=1S/C23H26N6O2/c1-3-17-22(31)27(2)19-13-25-23(26-21(19)29(17)16-6-4-5-7-16)28-11-10-14-12-15(20(24)30)8-9-18(14)28/h8-13,16-17H,3-7H2,1-2H3,(H2,24,30)/t17-/m1/s1 ZSYVDZWVCFZJLJ-QGZVFWFLSA-N 50285525 CHEMBL4161572 Serine/threonine-protein kinase PLK1 Homo sapiens 284 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285525&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145958192 104127096 ZINC26468200 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50999782 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)S(=O)(=O)NCCCO)ncc2N(C)C1=O InChI=1S/C23H32N6O4S/c1-3-19-22(31)28(2)20-15-24-23(27-21(20)29(19)17-7-4-5-8-17)26-16-9-11-18(12-10-16)34(32,33)25-13-6-14-30/h9-12,15,17,19,25,30H,3-8,13-14H2,1-2H3,(H,24,26,27)/t19-/m1/s1 GSXMJWLLQORXFR-LJQANCHMSA-N 50285526 CHEMBL4169129 Serine/threonine-protein kinase PLK1 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285526&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451364 104127097 ZINC00020407 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000156 CCNC(=O)c1ccc2n(ccc2c1)-c1ncc2N(C)C(=O)C(CC)N(c3ccn(C)n3)c2n1 InChI=1S/C24H26N8O2/c1-5-17-23(34)30(4)19-14-26-24(27-21(19)32(17)20-10-11-29(3)28-20)31-12-9-15-13-16(7-8-18(15)31)22(33)25-6-2/h7-14,17H,5-6H2,1-4H3,(H,25,33) CPIIAGDTJAFNTI-UHFFFAOYSA-N 50285533 CHEMBL4168951 Serine/threonine-protein kinase PLK1 Homo sapiens 4217 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145953240 104127104 ZINC26405043 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000284 CCC1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NC InChI=1S/C23H24N8O2/c1-5-16-22(33)29(4)18-13-25-23(26-20(18)31(16)19-9-10-28(3)27-19)30-11-8-14-12-15(21(32)24-2)6-7-17(14)30/h6-13,16H,5H2,1-4H3,(H,24,32) IHGSFRGRMMGZRN-UHFFFAOYSA-N 50285538 CHEMBL4164433 Serine/threonine-protein kinase PLK1 Homo sapiens 3175 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285538&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145958071 104127109 ZINC00020408 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000285 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NC(C)C InChI=1S/C26H32N6O2/c1-5-20-25(34)30(4)22-15-27-26(29-23(22)32(20)19-8-6-7-9-19)31-13-12-17-14-18(10-11-21(17)31)24(33)28-16(2)3/h10-16,19-20H,5-9H2,1-4H3,(H,28,33)/t20-/m1/s1 NMVMZFAZMNUQMX-HXUWFJFHSA-N 50285539 CHEMBL4174667 Serine/threonine-protein kinase PLK1 Homo sapiens 98 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285539&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145951269 104127110 ZINC26400973 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000286 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccc2ccccc12 InChI=1S/C22H25N5O/c1-3-17-21(28)25(2)19-14-23-22(24-20(19)27(17)16-9-5-6-10-16)26-13-12-15-8-4-7-11-18(15)26/h4,7-8,11-14,16-17H,3,5-6,9-10H2,1-2H3/t17-/m1/s1 CRUHGKWTRGGZNA-QGZVFWFLSA-N 50285540 CHEMBL4164991 Serine/threonine-protein kinase PLK1 Homo sapiens 1230 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285540&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58405790 104127111 ZINC00006466 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000287 CCC1N(c2ccn(C)n2)c2nc(Nc3ccc(cc3)S(=O)(=O)NCC(C)C)ncc2N(C)C1=O InChI=1S/C23H30N8O3S/c1-6-18-22(32)30(5)19-14-24-23(27-21(19)31(18)20-11-12-29(4)28-20)26-16-7-9-17(10-8-16)35(33,34)25-13-15(2)3/h7-12,14-15,18,25H,6,13H2,1-5H3,(H,24,26,27) KRFAHCVCYDZSOI-UHFFFAOYSA-N 50285541 CHEMBL4165409 Serine/threonine-protein kinase PLK1 Homo sapiens 883 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285541&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145955626 104127112 ZINC26467825 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000288 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)S(=O)(=O)Nc3ccccc3)ncc2N(C)C1=O InChI=1S/C26H30N6O3S/c1-3-22-25(33)31(2)23-17-27-26(29-24(23)32(22)20-11-7-8-12-20)28-18-13-15-21(16-14-18)36(34,35)30-19-9-5-4-6-10-19/h4-6,9-10,13-17,20,22,30H,3,7-8,11-12H2,1-2H3,(H,27,28,29)/t22-/m1/s1 YOMURATVIWHSOR-JOCHJYFZSA-N 50285536 CHEMBL4165706 Serine/threonine-protein kinase PLK1 Homo sapiens 109 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285536&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451386 104127107 ZINC26480627 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000289 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)S(=O)(=O)NC)ncc2N(C)C1=O InChI=1S/C21H28N6O3S/c1-4-17-20(28)26(3)18-13-23-21(25-19(18)27(17)15-7-5-6-8-15)24-14-9-11-16(12-10-14)31(29,30)22-2/h9-13,15,17,22H,4-8H2,1-3H3,(H,23,24,25)/t17-/m1/s1 PRMNYSLMFFRETJ-QGZVFWFLSA-N 50285537 CHEMBL4166771 Serine/threonine-protein kinase PLK1 Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285537&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451372 104127108 ZINC04618027 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000387 CCC1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NC(C)C InChI=1S/C25H28N8O2/c1-6-18-24(35)31(5)20-14-26-25(28-22(20)33(18)21-10-11-30(4)29-21)32-12-9-16-13-17(7-8-19(16)32)23(34)27-15(2)3/h7-15,18H,6H2,1-5H3,(H,27,34) ZNEZVBBGPCNEQS-UHFFFAOYSA-N 50285544 CHEMBL4171281 Serine/threonine-protein kinase PLK1 Homo sapiens 1517 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285544&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145949395 104127115 ZINC26470698 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000389 CCC1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NC1CCCC1 InChI=1S/C27H30N8O2/c1-4-20-26(37)33(3)22-16-28-27(30-24(22)35(20)23-12-13-32(2)31-23)34-14-11-17-15-18(9-10-21(17)34)25(36)29-19-7-5-6-8-19/h9-16,19-20H,4-8H2,1-3H3,(H,29,36) BTDUDLNWZXNLKL-UHFFFAOYSA-N 50285534 CHEMBL4164082 Serine/threonine-protein kinase PLK1 Homo sapiens 1213 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145958548 104127105 ZINC26470725 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000954 CCCNC(=O)c1ccc2n(ccc2c1)-c1ncc2N(C)C(=O)C(CC)N(c3ccn(C)n3)c2n1 InChI=1S/C25H28N8O2/c1-5-11-26-23(34)17-7-8-19-16(14-17)9-13-32(19)25-27-15-20-22(28-25)33(21-10-12-30(3)29-21)18(6-2)24(35)31(20)4/h7-10,12-15,18H,5-6,11H2,1-4H3,(H,26,34) IFQFOKVMLCZSRF-UHFFFAOYSA-N 50285584 CHEMBL4161027 Serine/threonine-protein kinase PLK1 Homo sapiens 2472 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285584&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145963541 104127155 ZINC00599038 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000956 CCC1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(N)=O InChI=1S/C22H22N8O2/c1-4-15-21(32)28(3)17-12-24-22(25-20(17)30(15)18-8-9-27(2)26-18)29-10-7-13-11-14(19(23)31)5-6-16(13)29/h5-12,15H,4H2,1-3H3,(H2,23,31) VJEHJUWRIDMKNR-UHFFFAOYSA-N 50285585 CHEMBL4172312 Serine/threonine-protein kinase PLK1 Homo sapiens 4991 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285585&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145950319 104127156 ZINC26495642 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000960 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NC1CCCC1 InChI=1S/C28H34N6O2/c1-3-22-27(36)32(2)24-17-29-28(31-25(24)34(22)21-10-6-7-11-21)33-15-14-18-16-19(12-13-23(18)33)26(35)30-20-8-4-5-9-20/h12-17,20-22H,3-11H2,1-2H3,(H,30,35)/t22-/m1/s1 VMFNGGJHVCGNJO-JOCHJYFZSA-N 50285531 CHEMBL4175722 Serine/threonine-protein kinase PLK1 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285531&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145973809 104127102 ZINC26405051 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000961 CCCCNC(=O)c1ccc2n(ccc2c1)-c1ncc2N(C)C(=O)[C@@H](CC)N(C3CCCC3)c2n1 InChI=1S/C27H34N6O2/c1-4-6-14-28-25(34)19-11-12-22-18(16-19)13-15-32(22)27-29-17-23-24(30-27)33(20-9-7-8-10-20)21(5-2)26(35)31(23)3/h11-13,15-17,20-21H,4-10,14H2,1-3H3,(H,28,34)/t21-/m1/s1 CIGSBKXHEYMHAF-OAQYLSRUSA-N 50285528 CHEMBL4160611 Serine/threonine-protein kinase PLK1 Homo sapiens 162 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285528&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145957415 104127099 ZINC03805716 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000962 CCCNC(=O)c1ccc2n(ccc2c1)-c1ncc2N(C)C(=O)[C@@H](CC)N(C3CCCC3)c2n1 InChI=1S/C26H32N6O2/c1-4-13-27-24(33)18-10-11-21-17(15-18)12-14-31(21)26-28-16-22-23(29-26)32(19-8-6-7-9-19)20(5-2)25(34)30(22)3/h10-12,14-16,19-20H,4-9,13H2,1-3H3,(H,27,33)/t20-/m1/s1 QBQNTNGYPHAFJA-HXUWFJFHSA-N 50285586 CHEMBL4164012 Serine/threonine-protein kinase PLK1 Homo sapiens 80 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285586&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145960780 104127157 ZINC26499457 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000963 CCNC(=O)c1ccc2n(ccc2c1)-c1ncc2N(C)C(=O)[C@@H](CC)N(C3CCCC3)c2n1 InChI=1S/C25H30N6O2/c1-4-19-24(33)29(3)21-15-27-25(28-22(21)31(19)18-8-6-7-9-18)30-13-12-16-14-17(10-11-20(16)30)23(32)26-5-2/h10-15,18-19H,4-9H2,1-3H3,(H,26,32)/t19-/m1/s1 HKERRRNEVQHIRB-LJQANCHMSA-N 50285547 CHEMBL4171770 Serine/threonine-protein kinase PLK1 Homo sapiens 62 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285547&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145951146 104127118 ZINC26474980 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000965 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(F)ccc12 InChI=1S/C22H24FN5O/c1-3-17-21(29)26(2)19-13-24-22(25-20(19)28(17)16-6-4-5-7-16)27-11-10-14-12-15(23)8-9-18(14)27/h8-13,16-17H,3-7H2,1-2H3/t17-/m1/s1 IXXVOBKEHRSFMP-QGZVFWFLSA-N 50285546 CHEMBL4172185 Serine/threonine-protein kinase PLK1 Homo sapiens 5611 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285546&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145952451 104127117 ZINC26480611 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000967 CCC1N(c2ccn(C)n2)c2nc(Nc3ccc(cc3)S(=O)(=O)NCCCO)ncc2N(C)C1=O InChI=1S/C22H28N8O4S/c1-4-17-21(32)29(3)18-14-23-22(26-20(18)30(17)19-10-12-28(2)27-19)25-15-6-8-16(9-7-15)35(33,34)24-11-5-13-31/h6-10,12,14,17,24,31H,4-5,11,13H2,1-3H3,(H,23,25,26) KHBSTEQSSXYFCY-UHFFFAOYSA-N 50285530 CHEMBL4175615 Serine/threonine-protein kinase PLK1 Homo sapiens 674 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285530&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145975475 104127101 ZINC03805714 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000971 CCC1N(c2ccn(C)n2)c2nc(Nc3ccc(cc3)S(=O)(=O)NCCO)ncc2N(C)C1=O InChI=1S/C21H26N8O4S/c1-4-16-20(31)28(3)17-13-22-21(25-19(17)29(16)18-9-11-27(2)26-18)24-14-5-7-15(8-6-14)34(32,33)23-10-12-30/h5-9,11,13,16,23,30H,4,10,12H2,1-3H3,(H,22,24,25) KSNXWDGHPBZSBU-UHFFFAOYSA-N 50285579 CHEMBL4173322 Serine/threonine-protein kinase PLK1 Homo sapiens 2411 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145949301 104127150 ZINC26498169 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000974 CCCNS(=O)(=O)c1ccc(Nc2ncc3N(C)C(=O)C(CC)N(c4ccn(C)n4)c3n2)cc1 InChI=1S/C22H28N8O3S/c1-5-12-24-34(32,33)16-9-7-15(8-10-16)25-22-23-14-18-20(26-22)30(19-11-13-28(3)27-19)17(6-2)21(31)29(18)4/h7-11,13-14,17,24H,5-6,12H2,1-4H3,(H,23,25,26) FMCBJKDUHHIOQB-UHFFFAOYSA-N 50285535 CHEMBL4168834 Serine/threonine-protein kinase PLK1 Homo sapiens 460 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285535&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145955296 104127106 ZINC03805705 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000976 CCC1N(c2ccn(C)n2)c2nc(Nc3ccc(cc3)S(N)(=O)=O)ncc2N(C)C1=O InChI=1S/C19H22N8O3S/c1-4-14-18(28)26(3)15-11-21-19(22-12-5-7-13(8-6-12)31(20,29)30)23-17(15)27(14)16-9-10-25(2)24-16/h5-11,14H,4H2,1-3H3,(H2,20,29,30)(H,21,22,23) WJBPINNYICOLHT-UHFFFAOYSA-N 50285532 CHEMBL4161861 Serine/threonine-protein kinase PLK1 Homo sapiens 1048 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285532&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145958954 104127103 ZINC26479768 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000979 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)S(=O)(=O)NCCO)ncc2N(C)C1=O InChI=1S/C22H30N6O4S/c1-3-18-21(30)27(2)19-14-23-22(26-20(19)28(18)16-6-4-5-7-16)25-15-8-10-17(11-9-15)33(31,32)24-12-13-29/h8-11,14,16,18,24,29H,3-7,12-13H2,1-2H3,(H,23,25,26)/t18-/m1/s1 UEILKDPTXUZCFH-GOSISDBHSA-N 50285587 CHEMBL4176983 Serine/threonine-protein kinase PLK1 Homo sapiens 25 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285587&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145971255 104127158 ZINC26499276 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000980 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)S(=O)(=O)NCC(C)C)ncc2N(C)C1=O InChI=1S/C24H34N6O3S/c1-5-20-23(31)29(4)21-15-25-24(28-22(21)30(20)18-8-6-7-9-18)27-17-10-12-19(13-11-17)34(32,33)26-14-16(2)3/h10-13,15-16,18,20,26H,5-9,14H2,1-4H3,(H,25,27,28)/t20-/m1/s1 UXNCNPVLRQGOMH-HXUWFJFHSA-N 50285545 CHEMBL4162262 Serine/threonine-protein kinase PLK1 Homo sapiens 47 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285545&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145961654 104127116 ZINC26474859 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000984 CCCCNS(=O)(=O)c1ccc(Nc2ncc3N(C)C(=O)[C@@H](CC)N(C4CCCC4)c3n2)cc1 InChI=1S/C24H34N6O3S/c1-4-6-15-26-34(32,33)19-13-11-17(12-14-19)27-24-25-16-21-22(28-24)30(18-9-7-8-10-18)20(5-2)23(31)29(21)3/h11-14,16,18,20,26H,4-10,15H2,1-3H3,(H,25,27,28)/t20-/m1/s1 XEXSGNRGTBSSOU-HXUWFJFHSA-N 50285582 CHEMBL4170176 Serine/threonine-protein kinase PLK1 Homo sapiens 41 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285582&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451382 104127153 ZINC26495645 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000985 CCCNS(=O)(=O)c1ccc(Nc2ncc3N(C)C(=O)[C@@H](CC)N(C4CCCC4)c3n2)cc1 InChI=1S/C23H32N6O3S/c1-4-14-25-33(31,32)18-12-10-16(11-13-18)26-23-24-15-20-21(27-23)29(17-8-6-7-9-17)19(5-2)22(30)28(20)3/h10-13,15,17,19,25H,4-9,14H2,1-3H3,(H,24,26,27)/t19-/m1/s1 SFNMDOXBLCGZMQ-LJQANCHMSA-N 50285529 CHEMBL4177399 Serine/threonine-protein kinase PLK1 Homo sapiens 35 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285529&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145973188 104127100 ZINC26482789 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000986 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3)S(N)(=O)=O)ncc2N(C)C1=O InChI=1S/C20H26N6O3S/c1-3-16-19(27)25(2)17-12-22-20(24-18(17)26(16)14-6-4-5-7-14)23-13-8-10-15(11-9-13)30(21,28)29/h8-12,14,16H,3-7H2,1-2H3,(H2,21,28,29)(H,22,23,24)/t16-/m1/s1 ZBJWJVGFIIULBV-MRXNPFEDSA-N 50285583 CHEMBL4168155 Serine/threonine-protein kinase PLK1 Homo sapiens 65 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285583&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145955731 104127154 ZINC26501189 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001006 CCCCNC(=O)c1ccc2n(ccc2c1)-c1ncc2N(C)C(=O)C(CC)N(c3ccn(C)n3)c2n1 InChI=1S/C26H30N8O2/c1-5-7-12-27-24(35)18-8-9-20-17(15-18)10-14-33(20)26-28-16-21-23(29-26)34(22-11-13-31(3)30-22)19(6-2)25(36)32(21)4/h8-11,13-16,19H,5-7,12H2,1-4H3,(H,27,35) PRJVGJUTDILMSU-UHFFFAOYSA-N 50285542 CHEMBL4160679 Serine/threonine-protein kinase PLK1 Homo sapiens 1147 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285542&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145957656 104127113 ZINC26480689 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001008 CCC1N(c2ccn(C)n2)c2nc(ncc2N(C)C1=O)-n1ccc2cc(ccc12)C(=O)NCC(C)C InChI=1S/C26H30N8O2/c1-6-19-25(36)32(5)21-15-28-26(29-23(21)34(19)22-10-11-31(4)30-22)33-12-9-17-13-18(7-8-20(17)33)24(35)27-14-16(2)3/h7-13,15-16,19H,6,14H2,1-5H3,(H,27,35) HCRPMWPXCKHVTF-UHFFFAOYSA-N 50285527 CHEMBL4174735 Serine/threonine-protein kinase PLK1 Homo sapiens 2556 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50285527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50285527&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145950845 104127098 ZINC26469304 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51001010 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 865 ChEMBL 10.1016/j.ejmech.2017.11.058 10.7270/Q27D2XPT 29220793 Zhan, MM; Yang, Y; Luo, J; Zhang, XX; Xiao, X; Li, S; Cheng, K; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831151 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 181 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831153 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccc(CCOCc2ccccc2)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C49H73N8O12P/c1-33(2)27-40(53-49(64)43-18-14-25-57(43)35(4)59)46(61)52-41(47(62)54-42(30-58)48(63)55-44(45(50)60)34(3)69-70(65,66)67)28-39-29-51-32-56(39)24-13-8-6-5-7-10-15-36-19-21-37(22-20-36)23-26-68-31-38-16-11-9-12-17-38/h9,11-12,16-17,19-22,29,32-34,40-44,58H,5-8,10,13-15,18,23-28,30-31H2,1-4H3,(H2,50,60)(H,52,61)(H,53,64)(H,54,62)(H,55,63)(H2,65,66,67)/t34-,40+,41+,42+,43+,44+/m1/s1 WQQABBZFVHSXMU-FWZUBCPGSA-N 50260124 CHEMBL4065187 Serine/threonine-protein kinase PLK1 Homo sapiens 9.7 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260124&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137632392 404340009 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831159 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1cccc(O)c1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C46H66FN8O13P/c1-28(2)22-36(51-46(63)39-18-13-21-55(39)30(4)57)43(60)50-37(44(61)52-38(26-56)45(62)53-41(42(48)59)29(3)68-69(64,65)66)23-31-25-49-27-54(31)20-10-8-6-5-7-9-16-34-35(47)17-12-19-40(34)67-33-15-11-14-32(58)24-33/h11-12,14-15,17,19,24-25,27-29,36-39,41,56,58H,5-10,13,16,18,20-23,26H2,1-4H3,(H2,48,59)(H,50,60)(H,51,63)(H,52,61)(H,53,62)(H2,64,65,66)/t29-,36+,37+,38+,39+,41+/m1/s1 SHZJITZSGHNGAS-USJNNXEMSA-N 50260121 CHEMBL4068949 Serine/threonine-protein kinase PLK1 Homo sapiens 5.5 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137632541 404340006 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831251 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C46H66FN8O12P/c1-29(2)24-36(51-46(62)39-20-15-23-55(39)31(4)57)43(59)50-37(44(60)52-38(27-56)45(61)53-41(42(48)58)30(3)67-68(63,64)65)25-32-26-49-28-54(32)22-13-8-6-5-7-12-18-34-35(47)19-14-21-40(34)66-33-16-10-9-11-17-33/h9-11,14,16-17,19,21,26,28-30,36-39,41,56H,5-8,12-13,15,18,20,22-25,27H2,1-4H3,(H2,48,58)(H,50,59)(H,51,62)(H,52,60)(H,53,61)(H2,63,64,65)/t30-,36+,37+,38+,39+,41+/m1/s1 XDRHCUWKZRZSEP-CQKJNDIKSA-N 50194933 CHEMBL3956625 Serine/threonine-protein kinase PLK1 Homo sapiens 127 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194933&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 134143682 375977039 CHEMBL3956625 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831277 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccc(CCO)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C42H67N8O12P/c1-27(2)22-33(46-42(58)36-13-11-20-50(36)29(4)53)39(55)45-34(40(56)47-35(25-52)41(57)48-37(38(43)54)28(3)62-63(59,60)61)23-32-24-44-26-49(32)19-10-8-6-5-7-9-12-30-14-16-31(17-15-30)18-21-51/h14-17,24,26-28,33-37,51-52H,5-13,18-23,25H2,1-4H3,(H2,43,54)(H,45,55)(H,46,58)(H,47,56)(H,48,57)(H2,59,60,61)/t28-,33+,34+,35+,36+,37+/m1/s1 KSMYGTHXVJXRTI-UONILZFISA-N 50260122 CHEMBL4092848 Serine/threonine-protein kinase PLK1 Homo sapiens 5.5 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260122&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137652774 404340007 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 50831301 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1c(F)cccc1Oc1cccc(OCc2ccccc2)c1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C53H72FN8O13P/c1-34(2)27-43(58-53(69)46-23-16-26-62(46)36(4)64)50(66)57-44(51(67)59-45(31-63)52(68)60-48(49(55)65)35(3)75-76(70,71)72)28-38-30-56-33-61(38)25-13-8-6-5-7-12-21-41-42(54)22-15-24-47(41)74-40-20-14-19-39(29-40)73-32-37-17-10-9-11-18-37/h9-11,14-15,17-20,22,24,29-30,33-35,43-46,48,63H,5-8,12-13,16,21,23,25-28,31-32H2,1-4H3,(H2,55,65)(H,57,66)(H,58,69)(H,59,67)(H,60,68)(H2,70,71,72)/t35-,43+,44+,45+,46+,48+/m1/s1 STDVQZAYBMZKHW-SMKGIDQESA-N 50260123 CHEMBL4080819 Serine/threonine-protein kinase PLK1 Homo sapiens 11 ChEMBL 10.1016/j.bmc.2017.02.063 10.7270/Q2QR50MP 28285924 Zhao, XZ; Hymel, D; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260123&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137648535 404340008 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139646 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@H]1Cc2c[n+](CCCCNC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)cn2CCCCCCCCc1ccccc1 InChI=1S/C44H69N8O11P/c1-30(2)25-35(47-43(58)38-20-16-24-52(38)32(4)54)40(55)46-36-26-34-27-50(29-51(34)23-14-8-6-5-7-10-17-33-18-11-9-12-19-33)22-15-13-21-45-44(59)39(31(3)63-64(60,61)62)49-42(57)37(28-53)48-41(36)56/h9,11-12,18-19,27,29-31,35-39,53H,5-8,10,13-17,20-26,28H2,1-4H3,(H6-,45,46,47,48,49,55,56,57,58,59,60,61,62)/p+1/t31-,35+,36+,37+,38+,39+/m1/s1 CXPHUBRUHJPONW-OUTQVYPCSA-O 50467109 CHEMBL4292295 Serine/threonine-protein kinase PLK1 Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467109&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145987182 433934374 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139647 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@H]1Cc2c[n+](CCCCCCNC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)cn2CCCCCCCCc1ccccc1 InChI=1S/C46H73N8O11P/c1-32(2)27-37(49-45(60)40-22-18-26-54(40)34(4)56)42(57)48-38-28-36-29-52(31-53(36)25-17-9-6-5-7-12-19-35-20-13-11-14-21-35)24-16-10-8-15-23-47-46(61)41(33(3)65-66(62,63)64)51-44(59)39(30-55)50-43(38)58/h11,13-14,20-21,29,31-33,37-41,55H,5-10,12,15-19,22-28,30H2,1-4H3,(H6-,47,48,49,50,51,57,58,59,60,61,62,63,64)/p+1/t33-,37+,38+,39+,40+,41+/m1/s1 KPDOBADQSPMGFP-OELJMHDBSA-O 50467110 CHEMBL4278200 Serine/threonine-protein kinase PLK1 Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467110&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145980261 433934375 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139651 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@H]1Cc2c[n+](CCCCCCNC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)cn2CCCCCCCCc1ccccc1 InChI=1S/C46H73N8O11P/c1-32(2)27-37(49-45(60)40-22-18-26-54(40)34(4)56)42(57)48-38-28-36-29-52(31-53(36)25-17-9-6-5-7-12-19-35-20-13-11-14-21-35)24-16-10-8-15-23-47-46(61)41(33(3)65-66(62,63)64)51-44(59)39(30-55)50-43(38)58/h11,13-14,20-21,29,31-33,37-41,55H,5-10,12,15-19,22-28,30H2,1-4H3,(H6-,47,48,49,50,51,57,58,59,60,61,62,63,64)/p+1/t33-,37+,38+,39+,40+,41+/m1/s1 KPDOBADQSPMGFP-OELJMHDBSA-O 50467110 CHEMBL4278200 Serine/threonine-protein kinase PLK1 Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467110&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145980261 433934375 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139652 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@H]1Cc2c[n+](CCCCCNC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)cn2CCCCCCCCc1ccccc1 InChI=1S/C45H71N8O11P/c1-31(2)26-36(48-44(59)39-21-17-25-53(39)33(4)55)41(56)47-37-27-35-28-51(30-52(35)24-16-8-6-5-7-11-18-34-19-12-9-13-20-34)23-15-10-14-22-46-45(60)40(32(3)64-65(61,62)63)50-43(58)38(29-54)49-42(37)57/h9,12-13,19-20,28,30-32,36-40,54H,5-8,10-11,14-18,21-27,29H2,1-4H3,(H6-,46,47,48,49,50,56,57,58,59,60,61,62,63)/p+1/t32-,36+,37+,38+,39+,40+/m1/s1 PVVRSMIEEGPASF-UTBDKNNCSA-O 50467111 CHEMBL4281659 Serine/threonine-protein kinase PLK1 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467111&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145979724 433934376 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139654 C[C@@H](OP(O)(O)=O)[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[n+](CCCCCNC1=O)cn2CCCCCCCCc1ccccc1)NC(C)=O InChI=1S/C34H53N6O9P/c1-25(49-50(46,47)48)31-34(45)35-18-12-8-13-19-39-22-28(21-29(36-26(2)42)32(43)37-30(23-41)33(44)38-31)40(24-39)20-14-6-4-3-5-9-15-27-16-10-7-11-17-27/h7,10-11,16-17,22,24-25,29-31,41H,3-6,8-9,12-15,18-21,23H2,1-2H3,(H5-,35,36,37,38,42,43,44,45,46,47,48)/p+1/t25-,29+,30+,31+/m1/s1 BXUVUZFLIDJEID-CNKGAEGWSA-O 50467112 CHEMBL4287557 Serine/threonine-protein kinase PLK1 Homo sapiens 8.0 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467112&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145990069 433934377 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139656 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@H]1Cc2c[n+](CCCCNC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)cn2CCCCCCCCc1ccccc1 InChI=1S/C44H69N8O11P/c1-30(2)25-35(47-43(58)38-20-16-24-52(38)32(4)54)40(55)46-36-26-34-27-50(29-51(34)23-14-8-6-5-7-10-17-33-18-11-9-12-19-33)22-15-13-21-45-44(59)39(31(3)63-64(60,61)62)49-42(57)37(28-53)48-41(36)56/h9,11-12,18-19,27,29-31,35-39,53H,5-8,10,13-17,20-26,28H2,1-4H3,(H6-,45,46,47,48,49,55,56,57,58,59,60,61,62)/p+1/t31-,35+,36+,37+,38+,39+/m1/s1 CXPHUBRUHJPONW-OUTQVYPCSA-O 50467109 CHEMBL4292295 Serine/threonine-protein kinase PLK1 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467109&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145987182 433934374 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139659 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@H]1Cc2c[n+](CCCCCNC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)cn2CCCCCCCCc1ccccc1 InChI=1S/C45H71N8O11P/c1-31(2)26-36(48-44(59)39-21-17-25-53(39)33(4)55)41(56)47-37-27-35-28-51(30-52(35)24-16-8-6-5-7-11-18-34-19-12-9-13-20-34)23-15-10-14-22-46-45(60)40(32(3)64-65(61,62)63)50-43(58)38(29-54)49-42(37)57/h9,12-13,19-20,28,30-32,36-40,54H,5-8,10-11,14-18,21-27,29H2,1-4H3,(H6-,46,47,48,49,50,56,57,58,59,60,61,62,63)/p+1/t32-,36+,37+,38+,39+,40+/m1/s1 PVVRSMIEEGPASF-UTBDKNNCSA-O 50467111 CHEMBL4281659 Serine/threonine-protein kinase PLK1 Homo sapiens 6.0 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467111&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145979724 433934376 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139660 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 4.0 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139661 C[C@@H](OP(O)(O)=O)[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[n+](CCCCCNC1=O)cn2CCCCCCCCc1ccccc1)NC(C)=O InChI=1S/C34H53N6O9P/c1-25(49-50(46,47)48)31-34(45)35-18-12-8-13-19-39-22-28(21-29(36-26(2)42)32(43)37-30(23-41)33(44)38-31)40(24-39)20-14-6-4-3-5-9-15-27-16-10-7-11-17-27/h7,10-11,16-17,22,24-25,29-31,41H,3-6,8-9,12-15,18-21,23H2,1-2H3,(H5-,35,36,37,38,42,43,44,45,46,47,48)/p+1/t25-,29+,30+,31+/m1/s1 BXUVUZFLIDJEID-CNKGAEGWSA-O 50467112 CHEMBL4287557 Serine/threonine-protein kinase PLK1 Homo sapiens 370 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467112&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 145990069 433934377 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139662 C[C@@H](OP(O)(O)=O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cncn1CCCCCCCCc1ccccc1)NC(C)=O)C(N)=O InChI=1S/C29H45N6O9P/c1-20(44-45(41,42)43)26(27(30)38)34-29(40)25(18-36)33-28(39)24(32-21(2)37)16-23-17-31-19-35(23)15-11-6-4-3-5-8-12-22-13-9-7-10-14-22/h7,9-10,13-14,17,19-20,24-26,36H,3-6,8,11-12,15-16,18H2,1-2H3,(H2,30,38)(H,32,37)(H,33,39)(H,34,40)(H2,41,42,43)/t20-,24+,25+,26+/m1/s1 RLKOZTUQTILVBD-CHQQOIJLSA-N 50467113 CHEMBL4285090 Serine/threonine-protein kinase PLK1 Homo sapiens 13000 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50467113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50467113&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71468090 433934378 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51139663 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2018.08.018 10.7270/Q25Q4ZST 30174151 Hymel, D; Grant, RA; Tsuji, K; Yaffe, MB; Burke, TR National Cancer Institute-Frederick http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168674 Cc1cc(O)cc2oc(=O)c3c(O)cc(O)cc3c12 InChI=1S/C14H10O5/c1-6-2-7(15)5-11-12(6)9-3-8(16)4-10(17)13(9)14(18)19-11/h2-5,15-17H,1H3 CEBXXEKPIIDJHL-UHFFFAOYSA-N 50479267 Alternariol::CHEBI:64983 Serine/threonine-protein kinase PLK1 Homo sapiens 26700 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50479267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50479267&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5359485 433946532 C16838 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168743 O[C@H]1CC(=O)c2c(O)ccc3-c4ccc(O)c5C(=O)CC[C@@](O)([C@H]1c23)c45 InChI=1S/C20H16O6/c21-10-3-1-8-9-2-4-11(22)17-12(23)5-6-20(26,18(9)17)19-14(25)7-13(24)16(10)15(8)19/h1-4,14,19,21-22,25-26H,5-7H2/t14-,19+,20-/m0/s1 GJIALGLHOBXNAT-KPOBHBOGSA-N 50479261 Altertoxin I Serine/threonine-protein kinase PLK1 Homo sapiens >28300 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50479261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50479261&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 104860 433946526 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168744 COc1cc(O)c2c(c1)-c1cc(O)c(O)cc1COC2=O InChI=1S/C15H12O6/c1-20-8-3-10-9-5-12(17)11(16)2-7(9)6-21-15(19)14(10)13(18)4-8/h2-5,16-18H,6H2,1H3 JAAWVSLYMPCCOD-UHFFFAOYSA-N 50479262 Alterlactone Serine/threonine-protein kinase PLK1 Homo sapiens >34600 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50479262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50479262&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24899917 433946527 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168745 Cc1cc(O)c(O)cc1-c1cc(O)cc(O)c1C(O)=O InChI=1S/C14H12O6/c1-6-2-10(16)11(17)5-8(6)9-3-7(15)4-12(18)13(9)14(19)20/h2-5,15-18H,1H3,(H,19,20) LACFACJZTLCIGY-UHFFFAOYSA-N 50479263 Desmethylaltenusin Serine/threonine-protein kinase PLK1 Homo sapiens >36200 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50479263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50479263&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24900160 433946528 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168746 COc1cc(O)c2c(c1)c1c(C)cc(O)c(O)c1oc2=O InChI=1S/C15H12O6/c1-6-3-10(17)13(18)14-11(6)8-4-7(20-2)5-9(16)12(8)15(19)21-14/h3-5,16-18H,1-2H3 BVYAURIYXKOUPX-UHFFFAOYSA-N 50479266 CHEMBL520144 Serine/threonine-protein kinase PLK1 Homo sapiens 19700 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50479266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50479266&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24899916 433946531 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168747 Cc1cc(O)cc2oc(=O)c3c(O)cc(OS(O)(=O)=O)cc3c12 InChI=1S/C14H10O8S/c1-6-2-7(15)3-11-12(6)9-4-8(22-23(18,19)20)5-10(16)13(9)14(17)21-11/h2-5,15-16H,1H3,(H,18,19,20) IOBDCMVQCAWFQQ-UHFFFAOYSA-N 50479264 Alternariol 5-O-Sulfate::CHEMBL483525 Serine/threonine-protein kinase PLK1 Homo sapiens 13000 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50479264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50479264&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24899915 433946529 C02000 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168785 COc1cc(O)c2c(c1)c1c(C)cc(O)cc1oc2=O InChI=1S/C15H12O5/c1-7-3-8(16)4-12-13(7)10-5-9(19-2)6-11(17)14(10)15(18)20-12/h3-6,16-17H,1-2H3 LCSDQFNUYFTXMT-UHFFFAOYSA-N 50276157 Alternariol 5-O-Methyl Ether::CHEMBL483526 Serine/threonine-protein kinase PLK1 Homo sapiens 30100 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50276157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50276157&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5360741 405257408 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168809 COc1cc(O)c(C(O)=O)c(c1)C1=C(C)C[C@@H](O)C1=O InChI=1S/C14H14O6/c1-6-3-10(16)13(17)11(6)8-4-7(20-2)5-9(15)12(8)14(18)19/h4-5,10,15-16H,3H2,1-2H3,(H,18,19)/t10-/m1/s1 KZPGRZQYEBJXQJ-SNVBAGLBSA-N 50479265 Alternarienonic Acid Serine/threonine-protein kinase PLK1 Homo sapiens >35900 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50479265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50479265&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24900161 433946530 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168810 COc1cc(O)c(C(O)=O)c(c1)-c1cc(O)c(O)cc1C InChI=1S/C15H14O6/c1-7-3-11(16)12(17)6-9(7)10-4-8(21-2)5-13(18)14(10)15(19)20/h3-6,16-18H,1-2H3,(H,19,20) ADPBTBPPIIKLEH-UHFFFAOYSA-N 50576 2-(4,5-dihydroxy-2-methyl-phenyl)-6-hydroxy-4-methoxy-benzoic acid::2-(4,5-dihydroxy-2-methylphenyl)-6-hydroxy-4-methoxybenzoic acid::4-methoxy-2-[2-methyl-4,5-bis(oxidanyl)phenyl]-6-oxidanyl-benzoic acid::MLS000877038::SMR000440664::cid_6918469 Serine/threonine-protein kinase PLK1 Homo sapiens 24400 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6918469 252630835 ZINC13150834 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51168871 COc1cc2c(C(=O)OC22C(C)CC(=O)C2=O)c(O)c1 InChI=1S/C14H12O6/c1-6-3-10(16)12(17)14(6)8-4-7(19-2)5-9(15)11(8)13(18)20-14/h4-6,15H,3H2,1-2H3 RHTVEOLOMRDENY-UHFFFAOYSA-N 50375300 TALAROFLAVONE Serine/threonine-protein kinase PLK1 Homo sapiens >36200 ChEMBL 10.1021/np070447m 10.7270/Q2GB26VV 18494522 Aly, AH; Edrada-Ebel, R; Indriani, ID; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Proksch, P; Ebel, R Heinrich-Heine-Universit£t http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50375300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50375300&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 91930144 160854390 ZINC14719711 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181703 C[N+](C)(C)[C@H](Cc1cc(I)c(O)c(I)c1)C([O-])=O InChI=1S/C12H15I2NO3/c1-15(2,3)10(12(17)18)6-7-4-8(13)11(16)9(14)5-7/h4-5,10H,6H2,1-3H3,(H-,16,17,18)/t10-/m1/s1 UNHBUPMPUJBNCA-SNVBAGLBSA-N 50486136 Purpuroine G Serine/threonine-protein kinase PLK1 Homo sapiens 21000 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486136&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71462929 433953401 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181706 C[N+](C)(C)[C@H](CCOc1c(Cl)cc(Br)cc1Cl)C([O-])=O InChI=1S/C13H16BrCl2NO3/c1-17(2,3)11(13(18)19)4-5-20-12-9(15)6-8(14)7-10(12)16/h6-7,11H,4-5H2,1-3H3/t11-/m1/s1 FNZSBVCUBBTGET-LLVKDONJSA-N 50486138 Purpuroine C Serine/threonine-protein kinase PLK1 Homo sapiens 17900 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486138&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71462927 433953403 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181707 COc1c(I)cc(C[C@H](C([O-])=O)[N+](C)(C)C)cc1I InChI=1S/C13H17I2NO3/c1-16(2,3)11(13(17)18)7-8-5-9(14)12(19-4)10(15)6-8/h5-6,11H,7H2,1-4H3/t11-/m1/s1 KUAOAGSKKMAQQJ-LLVKDONJSA-N 50486139 Purpuroine F Serine/threonine-protein kinase PLK1 Homo sapiens 9200 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486139&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71461186 433953404 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181709 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 1970 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181710 C[N+](C)(C)[C@H](Cc1cc(Br)c(O)c(I)c1)C([O-])=O InChI=1S/C12H15BrINO3/c1-15(2,3)10(12(17)18)6-7-4-8(13)11(16)9(14)5-7/h4-5,10H,6H2,1-3H3,(H-,16,17,18)/t10-/m1/s1 JRMILWBTUZMVEQ-SNVBAGLBSA-N 50486140 Purpuroine I Serine/threonine-protein kinase PLK1 Homo sapiens >116000 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486140&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454037 433953405 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181711 C[N+](C)(C)[C@H](CCOc1ccc(Br)cc1Br)C([O-])=O InChI=1S/C13H17Br2NO3/c1-16(2,3)11(13(17)18)6-7-19-12-5-4-9(14)8-10(12)15/h4-5,8,11H,6-7H2,1-3H3/t11-/m1/s1 WSYAJSUDDFHTBT-LLVKDONJSA-N 50486141 Purpuroine B Serine/threonine-protein kinase PLK1 Homo sapiens >126000 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486141&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454033 433953406 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181717 COc1c(Br)cc(C[C@H](C([O-])=O)[N+](C)(C)C)cc1I InChI=1S/C13H17BrINO3/c1-16(2,3)11(13(17)18)7-8-5-9(14)12(19-4)10(15)6-8/h5-6,11H,7H2,1-4H3/t11-/m1/s1 YVFRPWMJWCFFSL-LLVKDONJSA-N 50486137 Purpuroine H Serine/threonine-protein kinase PLK1 Homo sapiens 16900 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486137&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459442 433953402 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181722 C[N+](C)(C)[C@H](CCOc1c(Br)cc(Br)cc1I)C([O-])=O InChI=1S/C13H16Br2INO3/c1-17(2,3)11(13(18)19)4-5-20-12-9(15)6-8(14)7-10(12)16/h6-7,11H,4-5H2,1-3H3/t11-/m1/s1 RVCDCTOZQNXIPD-LLVKDONJSA-N 50486144 Purpuroine D Serine/threonine-protein kinase PLK1 Homo sapiens 2870 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486144&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71454035 433953409 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181731 C[N+](C)(C)[C@H](CCOc1c(Br)cc(Br)cc1Br)C([O-])=O InChI=1S/C13H16Br3NO3/c1-17(2,3)11(13(18)19)4-5-20-12-9(15)6-8(14)7-10(12)16/h6-7,11H,4-5H2,1-3H3/t11-/m1/s1 PKQKGGKFHVXXND-LLVKDONJSA-N 50486143 Purpuroine A Serine/threonine-protein kinase PLK1 Homo sapiens >105000 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486143&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71450398 433953408 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51181732 COc1cc(Br)c(C[C@H](C([O-])=O)[N+](C)(C)C)c(Br)c1 InChI=1S/C13H17Br2NO3/c1-16(2,3)12(13(17)18)7-9-10(14)5-8(19-4)6-11(9)15/h5-6,12H,7H2,1-4H3/t12-/m1/s1 HPWZPBRHLVYCSN-GFCCVEGCSA-N 50486142 CHEMBL2204075 Serine/threonine-protein kinase PLK1 Homo sapiens >126000 ChEMBL 10.1016/j.bmc.2012.10.014 10.7270/Q2MP565Q 23131412 Shen, S; Liu, D; Wei, C; Proksch, P; Lin, W Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50486142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50486142&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71459445 433953407 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51171026 COc1cc(O)c2C(=O)C3=C([C@@H](O)[C@](C)(O)[C@H](O)[C@H]3O)C(=O)c2c1-c1c(O)c2C(=O)c3cc(O)c(C)cc3C(=O)c2cc1OC InChI=1S/C32H26O13/c1-9-5-10-11(6-13(9)33)25(36)17-12(24(10)35)7-15(44-3)20(26(17)37)19-16(45-4)8-14(34)18-21(19)28(39)23-22(27(18)38)29(40)31(42)32(2,43)30(23)41/h5-8,29-31,33-34,37,40-43H,1-4H3/t29-,30+,31+,32-/m0/s1 WNKYPOGUIDZODB-BVEPWEIPSA-N 50480482 Alterporriol G/H::CHEBI:65389 Serine/threonine-protein kinase PLK1 Homo sapiens >16100 ChEMBL 10.1021/np8004997 10.7270/Q2ZS30C9 19271717 Debbab, A; Aly, AH; Edrada-Ebel, R; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Mosaddak, M; Hakiki, A; Proksch, P; Ebel, R Heinrich-Heine-Universitat http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50480482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50480482&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42639664 433947747 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51171048 COc1cc(O)c2C(=O)c3cc(O)c(C)cc3C(=O)c2c1 InChI=1S/C16H12O5/c1-7-3-9-10(6-12(7)17)16(20)14-11(15(9)19)4-8(21-2)5-13(14)18/h3-6,17-18H,1-2H3 FKTPLNFTYJEAAB-UHFFFAOYSA-N 50480484 Macrosporin Serine/threonine-protein kinase PLK1 Homo sapiens >35100 ChEMBL 10.1021/np8004997 10.7270/Q2ZS30C9 19271717 Debbab, A; Aly, AH; Edrada-Ebel, R; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Mosaddak, M; Hakiki, A; Proksch, P; Ebel, R Heinrich-Heine-Universitat http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50480484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50480484&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 159926 433947749 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51171069 COc1cc(O)c2C(=O)C3=C([C@@H](O)[C@](C)(O)[C@H](O)[C@H]3O)C(=O)c2c1 InChI=1S/C16H16O8/c1-16(23)14(21)10-9(13(20)15(16)22)12(19)8-6(11(10)18)3-5(24-2)4-7(8)17/h3-4,13-15,17,20-23H,1-2H3/t13-,14+,15+,16-/m0/s1 VSMBLBOUQJNJIL-JJXSEGSLSA-N 50480485 Altersolanol A::CHEBI:2615 Serine/threonine-protein kinase PLK1 Homo sapiens 14200 ChEMBL 10.1021/np8004997 10.7270/Q2ZS30C9 19271717 Debbab, A; Aly, AH; Edrada-Ebel, R; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Mosaddak, M; Hakiki, A; Proksch, P; Ebel, R Heinrich-Heine-Universitat http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50480485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50480485&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 89644 433947750 C10296 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51171100 COc1cc(O)c2C(=O)c3c(O)c(O)c(C)cc3C(=O)c2c1 InChI=1S/C16H12O6/c1-6-3-8-12(16(21)13(6)18)15(20)11-9(14(8)19)4-7(22-2)5-10(11)17/h3-5,17-18,21H,1-2H3 IOPGGNYCFGEWPF-UHFFFAOYSA-N 50480483 6-O-Methylalaternin::CHEMBL556684 Serine/threonine-protein kinase PLK1 Homo sapiens >33300 ChEMBL 10.1021/np8004997 10.7270/Q2ZS30C9 19271717 Debbab, A; Aly, AH; Edrada-Ebel, R; Wray, V; Müller, WE; Totzke, F; Zirrgiebel, U; Schächtele, C; Kubbutat, MH; Lin, WH; Mosaddak, M; Hakiki, A; Proksch, P; Ebel, R Heinrich-Heine-Universitat http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50480483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50480483&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 177458 433947748 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51210745 COc1cc(CNCc2ccncc2)ccc1OCc1ccc(Cl)cc1 InChI=1S/C21H21ClN2O2/c1-25-21-12-18(14-24-13-16-8-10-23-11-9-16)4-7-20(21)26-15-17-2-5-19(22)6-3-17/h2-12,24H,13-15H2,1H3 WQKKJLNOWMZBOW-UHFFFAOYSA-N 50497566 CHEMBL3344193 Serine/threonine-protein kinase PLK1 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2014.09.015 10.7270/Q26Q2171 25304894 Carrasco-Gomez, R; Keppner-Witter, S; Hieke, M; Lange, L; Schneider, G; Schubert-Zsilavecz, M; Proschak, E; Spänkuch, B Johann-Wolfgang-Goethe University of Frankfurt http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50497566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50497566&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3162171 433964831 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51215992 OC(=O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2)C1 InChI=1S/C18H17Cl2NO3/c19-16-6-3-13(7-17(16)20)11-24-15-4-1-12(2-5-15)8-21-9-14(10-21)18(22)23/h1-7,14H,8-11H2,(H,22,23) WAAWETUDFSIYSD-UHFFFAOYSA-N 50499634 CHEMBL3741589 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00928 10.7270/Q2PZ5CV4 26509640 Hobson, AD; Harris, CM; van der Kam, EL; Turner, SC; Abibi, A; Aguirre, AL; Bousquet, P; Kebede, T; Konopacki, DB; Gintant, G; Kim, Y; Larson, K; Maull, JW; Moore, NS; Shi, D; Shrestha, A; Tang, X; Zhang, P; Sarris, KK AbbVie Bioresearch Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499634&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46872626 433911535 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51217237 C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1 VRQXRVAKPDCRCI-ZNMIVQPWSA-N 106870 US8592455, 70 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01275 10.7270/Q2H41VGN 26505898 Burger, MT; Nishiguchi, G; Han, W; Lan, J; Simmons, R; Atallah, G; Ding, Y; Tamez, V; Zhang, Y; Mathur, M; Muller, K; Bellamacina, C; Lindvall, MK; Zang, R; Huh, K; Feucht, P; Zavorotinskaya, T; Dai, Y; Basham, S; Chan, J; Ginn, E; Aycinena, A; Holash, J; Castillo, J; Langowski, JL; Wang, Y; Chen, MY; Lambert, A; Fritsch, C; Kauffmann, A; Pfister, E; Vanasse, KG; Garcia, PD Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106870&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5H7 5DWR 44814409 174009181 ZINC96177711 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51254177 N[C@@H](CSC1c2c(sc(C(N)=O)[n+]2[O-])C(C=C1SC(F)(F)F)[N+]([O-])=O)C(O)=O InChI=1S/C12H11F3N4O6S3/c13-12(14,15)28-5-1-4(19(24)25)7-6(18(23)10(27-7)9(17)20)8(5)26-2-3(16)11(21)22/h1,3-4,8H,2,16H2,(H2,17,20)(H,21,22)/t3-,4?,8?/m0/s1 AVDXSVRSADUAPX-MTHKCKAPSA-N 50512859 CHEMBL4531713 Serine/threonine-protein kinase PLK1 Homo sapiens 400 ChEMBL 10.1021/acs.jmedchem.8b01153 10.7270/Q2959MWN 30565923 Gehringer, M; Laufer, SA Eberhard Karls University T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50512859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50512859&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155546408 440721441 C05726 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51254179 N[C@@H](CSC1c2c(sc(C(N)=O)[n+]2[O-])C(C=C1C(F)(F)F)[N+]([O-])=O)C(O)=O InChI=1S/C12H11F3N4O6S2/c13-12(14,15)3-1-5(19(24)25)8-6(18(23)10(27-8)9(17)20)7(3)26-2-4(16)11(21)22/h1,4-5,7H,2,16H2,(H2,17,20)(H,21,22)/t4-,5?,7?/m0/s1 BYQNDYOTPWGHJF-JZMYEYFNSA-N 50512860 CHEMBL4583439 Serine/threonine-protein kinase PLK1 Homo sapiens 2500 ChEMBL 10.1021/acs.jmedchem.8b01153 10.7270/Q2959MWN 30565923 Gehringer, M; Laufer, SA Eberhard Karls University T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50512860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50512860&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155562100 440721442 C05726 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51256944 Cc1ccc2n(c(CCN3C(=O)c4cccc5cccc(C3=O)c45)nc2c1)-c1ccncc1 InChI=1S/C27H20N4O2/c1-17-8-9-23-22(16-17)29-24(31(23)19-10-13-28-14-11-19)12-15-30-26(32)20-6-2-4-18-5-3-7-21(25(18)20)27(30)33/h2-11,13-14,16H,12,15H2,1H3 VFDVYUMIEWOVJX-UHFFFAOYSA-N 50513788 CHEMBL4558162 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b00224 10.7270/Q22B92CV 30888810 Huang, YY; Yu, YF; Zhang, C; Chen, Y; Zhou, Q; Li, Z; Zhou, S; Li, Z; Guo, L; Wu, D; Wu, Y; Luo, HB Sun Yat-sen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50513788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50513788&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search AEL 6IJI 137700779 440722370 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51237788 CN(c1cccc2CN(Cc12)c1nc(Nc2ccc(cc2)N2CCN(CC2)C(C)=O)ncc1C(F)(F)F)S(C)(=O)=O InChI=1S/C27H30F3N7O3S/c1-18(38)35-11-13-36(14-12-35)21-9-7-20(8-10-21)32-26-31-15-23(27(28,29)30)25(33-26)37-16-19-5-4-6-24(22(19)17-37)34(2)41(3,39)40/h4-10,15H,11-14,16-17H2,1-3H3,(H,31,32,33) OIXHMSMLJCOUJT-UHFFFAOYSA-N 50506637 CHEMBL4476226 Serine/threonine-protein kinase PLK1 Homo sapiens 8.8 ChEMBL 10.1016/j.bmcl.2018.10.013 10.7270/Q23T9MHD 30340900 Choi, MJ; Roh, EJ; Hur, W; Lee, SH; Sim, T; Oh, CH; Lee, SH; Kim, JS; Yoo, KH Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506637&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155538441 440715222 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51240127 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1021/acsmedchemlett.8b00364 10.7270/Q2GQ7214 30613326 Meyers, J; Chessum, NEA; Ali, S; Mok, NY; Wilding, B; Pasqua, AE; Rowlands, M; Tucker, MJ; Evans, LE; Rye, CS; O'Fee, L; Le Bihan, YV; Burke, R; Carter, M; Workman, P; Blagg, J; Brown, N; van Montfort, RLM; Jones, K; Cheeseman, MD The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51238687 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 222 ChEMBL 10.1016/j.ejmech.2018.10.052 10.7270/Q2W380MT 30384048 Narayan, S; Ramisetti, S; Jaiswal, AS; Law, BK; Singh-Pillay, A; Singh, P; Amin, S; Sharma, AK University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51271248 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 830 ChEMBL 10.1021/acs.jmedchem.9b00353 10.7270/Q2X06BF7 31381325 Qi, B; Zhong, L; He, J; Zhang, H; Li, F; Wang, T; Zou, J; Lin, YX; Zhang, C; Guo, X; Li, R; Shi, J Chengdu University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51271255 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1 InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31) BKWJAKQVGHWELA-UHFFFAOYSA-N 50240826 AZD-1775::MK-1775::US11124518, Example AZD1775::US11248006, Compound AZD1775::US11479555, Example AZD1775 Serine/threonine-protein kinase PLK1 Homo sapiens 350 ChEMBL 10.1021/acs.jmedchem.9b00353 10.7270/Q2X06BF7 31381325 Qi, B; Zhong, L; He, J; Zhang, H; Li, F; Wang, T; Zou, J; Lin, YX; Zhang, C; Guo, X; Li, R; Shi, J Chengdu University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 8X7 5VDK,5VD0,5V5Y,8BJT 24856436 386401532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51271258 Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1 InChI=1S/C21H13Cl2N3O2S/c22-17-6-4-15(11-18(17)23)19(27)25-16-5-3-12-9-14(2-1-13(12)10-16)20(28)26-21-24-7-8-29-21/h1-11H,(H,25,27)(H,24,26,28) MRITYVDXXFOOAU-UHFFFAOYSA-N 50519158 CHEMBL4445812 Serine/threonine-protein kinase PLK1 Homo sapiens 55 ChEMBL 10.1021/acs.jmedchem.9b00353 10.7270/Q2X06BF7 31381325 Qi, B; Zhong, L; He, J; Zhang, H; Li, F; Wang, T; Zou, J; Lin, YX; Zhang, C; Guo, X; Li, R; Shi, J Chengdu University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519158&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 138911334 440727740 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51273053 CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) WVGDUQVQWLHVEA-UHFFFAOYSA-N 50519662 CHEMBL4438748 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01143 10.7270/Q2MC93FG 31693351 Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519662&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155513187 440728244 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51326394 Cc1sc(cc1-c1cnn2cc(Cl)cnc12)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F InChI=1S/C18H18ClF2N5OS/c1-9-11(12-7-24-26-8-10(19)6-23-16(12)26)5-14(28-9)17(27)25-15-13(22)3-2-4-18(15,20)21/h5-8,13,15H,2-4,22H2,1H3,(H,25,27)/t13-,15-/m1/s1 NGFGTMFVWSDFPS-UKRRQHHQSA-N 50536681 CHEMBL4552628 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536681&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 89735655 440827505 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51326519 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)NCC(F)(F)F InChI=1S/C17H13F3N6OS/c1-25-6-12(4-23-25)11-3-21-15-13(5-24-26(15)7-11)10-2-14(28-8-10)16(27)22-9-17(18,19)20/h2-8H,9H2,1H3,(H,22,27) UEFCSGDOOJJXTN-UHFFFAOYSA-N 50536678 CHEMBL4550702 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536678&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 59603829 440827502 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51278889 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 UIYQCJDQBRUFEV-FALOATQWSA-N 50403017 CHEMBL2207846 Serine/threonine-protein kinase PLK1 Homo sapiens 620 ChEMBL 10.1016/j.bmc.2019.07.005 10.7270/Q2RB7819 31300317 Bozorov, K; Zhao, J; Aisa, HA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49873221 163352041 CHEMBL2207846 ZINC95564030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51278901 OCc1ccc(cc1)C(=O)NCCC(=O)N[C@@H](Cc1cnnn1CCCCCCCCc1ccccc1)C(=O)NCc1cnnn1CCP(O)(O)=O InChI=1S/C35H48N9O7P/c45-26-28-13-15-29(16-14-28)34(47)36-18-17-33(46)40-32(35(48)37-23-31-25-39-42-44(31)20-21-52(49,50)51)22-30-24-38-41-43(30)19-9-4-2-1-3-6-10-27-11-7-5-8-12-27/h5,7-8,11-16,24-25,32,45H,1-4,6,9-10,17-23,26H2,(H,36,47)(H,37,48)(H,40,46)(H2,49,50,51)/t32-/m0/s1 CXBGPTRHNUQBFI-YTTGMZPUSA-N 50521865 CHEMBL4445650 Serine/threonine-protein kinase PLK1 Homo sapiens 3370 ChEMBL 10.1016/j.bmc.2019.07.005 10.7270/Q2RB7819 31300317 Bozorov, K; Zhao, J; Aisa, HA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521865&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155518015 440730447 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51326243 FC(F)(F)CNC(=O)c1cc(cs1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCCCC2)cc1 InChI=1S/C26H26F3N5O2S/c27-26(28,29)17-31-25(35)23-12-19(16-37-23)22-14-32-34-15-20(13-30-24(22)34)18-4-6-21(7-5-18)36-11-10-33-8-2-1-3-9-33/h4-7,12-16H,1-3,8-11,17H2,(H,31,35) QNABDSWBQJKBHK-UHFFFAOYSA-N 50536675 CHEMBL4569508 Serine/threonine-protein kinase PLK1 Homo sapiens 55000 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536675&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24759534 440827499 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51326343 Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1 LYADGAGFYYXXIO-ZWKOTPCHSA-N 50536679 CHEMBL4568087 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2016.02.003 10.7270/Q2NP27X5 27491711 Sloman, DL; Noucti, N; Altman, MD; Chen, D; Mislak, AC; Szewczak, A; Hayashi, M; Warren, L; Dellovade, T; Wu, Z; Marcus, J; Walker, D; Su, HP; Edavettal, SC; Munshi, S; Hutton, M; Nuthall, H; Stanton, MG Merck and Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50536679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50536679&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 59603842 440827503 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51311445 COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1 InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m0/s1 LTTJGQBDGMNWHJ-SANMLTNESA-N 50532181 CHEMBL4474690 Serine/threonine-protein kinase PLK1 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2019.02.006 10.7270/Q22F7RXK 30755337 Ikegashira, K; Ikenogami, T; Yamasaki, T; Oka, T; Hase, Y; Miyagawa, N; Inagaki, K; Kawahara, I; Koga, Y; Hashimoto, H Japan Tobacco Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532181&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search A7O 6IG8 49806372 440740763 C02773 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 924002 Clc1nc(NCc2ccccn2)c2c(cccc2n1)-c1ccccc1 InChI=1S/C20H15ClN4/c21-20-24-17-11-6-10-16(14-7-2-1-3-8-14)18(17)19(25-20)23-13-15-9-4-5-12-22-15/h1-12H,13H2,(H,23,24,25) JSYVMXAHYRRFOQ-UHFFFAOYSA-N 357015 US10214511, Example 19::US10676460, Example 19 Serine/threonine-protein kinase PLK1 Homo sapiens 50000 US Patent 10.7270/Q2QZ2F1C aid1804571 US10676460 Johnson, JA; Lloyd, J; Finlay, H; Neels, J; Dhondi, NK; Gunaga, P; Banerjee, A; Adisechan, A Bristol-Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=357015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=357015&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 86670613 386396597 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317990 CCn1c2ccccc2c2cc(\C=N\NC(=O)c3ccccc3[N+]([O-])=O)ccc12 InChI=1S/C22H18N4O3/c1-2-25-19-9-5-3-7-16(19)18-13-15(11-12-20(18)25)14-23-24-22(27)17-8-4-6-10-21(17)26(28)29/h3-14H,2H2,1H3,(H,24,27)/b23-14+ MHYREVAJCRVGII-OEAKJJBVSA-N 50533476 CHEMBL4560457 Serine/threonine-protein kinase PLK1 Homo sapiens 66100 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533476&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6865595 440742058 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317991 CCn1c2ccccc2c2cc(\C=N\NC(=O)c3ccccc3[N+]([O-])=O)ccc12 InChI=1S/C22H18N4O3/c1-2-25-19-9-5-3-7-16(19)18-13-15(11-12-20(18)25)14-23-24-22(27)17-8-4-6-10-21(17)26(28)29/h3-14H,2H2,1H3,(H,24,27)/b23-14+ MHYREVAJCRVGII-OEAKJJBVSA-N 50533476 CHEMBL4560457 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533476&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6865595 440742058 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317992 CCc1ccc(\C=N\NC(=O)C2=C(Cl)c3ccc(Cl)cc3C2)s1 InChI=1S/C17H14Cl2N2OS/c1-2-12-4-5-13(23-12)9-20-21-17(22)15-8-10-7-11(18)3-6-14(10)16(15)19/h3-7,9H,2,8H2,1H3,(H,21,22)/b20-9+ AOQXJGFKAZTXFC-AWQFTUOYSA-N 50533477 CHEMBL4439895 Serine/threonine-protein kinase PLK1 Homo sapiens 83900 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533477&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155514091 440742059 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317993 Cc1ccccc1OCC(=O)N\N=C\c1ccc2OCCOc2c1 InChI=1S/C18H18N2O4/c1-13-4-2-3-5-15(13)24-12-18(21)20-19-11-14-6-7-16-17(10-14)23-9-8-22-16/h2-7,10-11H,8-9,12H2,1H3,(H,20,21)/b19-11+ LUYKDALVAGNUCX-YBFXNURJSA-N 50533478 CHEMBL1965126 Serine/threonine-protein kinase PLK1 Homo sapiens 44200 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533478&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6871427 440742060 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317994 Clc1cc(Cl)cc(\C=N\NC(=O)CCn2c3ccccc3c3ccccc23)c1 InChI=1S/C22H17Cl2N3O/c23-16-11-15(12-17(24)13-16)14-25-26-22(28)9-10-27-20-7-3-1-5-18(20)19-6-2-4-8-21(19)27/h1-8,11-14H,9-10H2,(H,26,28)/b25-14+ HRVYHSZOVIIJMZ-AFUMVMLFSA-N 50533479 CHEMBL4460805 Serine/threonine-protein kinase PLK1 Homo sapiens 68100 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533479&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155527682 440742061 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317995 CCn1c2ccccc2c2cc(\C=N\NC(=O)c3cccc(Cl)c3)ccc12 InChI=1S/C22H18ClN3O/c1-2-26-20-9-4-3-8-18(20)19-12-15(10-11-21(19)26)14-24-25-22(27)16-6-5-7-17(23)13-16/h3-14H,2H2,1H3,(H,25,27)/b24-14+ KLUVBVFLFHBDOC-ZVHZXABRSA-N 50533480 CHEMBL4451672 Serine/threonine-protein kinase PLK1 Homo sapiens 46700 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533480&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5332523 440742062 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317996 CCN(CC)c1ccc(NC(=O)\C=C\c2cccc3ccccc23)cc1 InChI=1S/C23H24N2O/c1-3-25(4-2)21-15-13-20(14-16-21)24-23(26)17-12-19-10-7-9-18-8-5-6-11-22(18)19/h5-17H,3-4H2,1-2H3,(H,24,26)/b17-12+ NXMRRUDVWMQHRN-SFQUDFHCSA-N 50533481 CHEMBL4553008 Serine/threonine-protein kinase PLK1 Homo sapiens 26800 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533481&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 681379 440742063 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317997 CCCc1oc2ccc(NS(=O)(=O)c3cccs3)cc2c1C(=O)OCC InChI=1S/C18H19NO5S2/c1-3-6-15-17(18(20)23-4-2)13-11-12(8-9-14(13)24-15)19-26(21,22)16-7-5-10-25-16/h5,7-11,19H,3-4,6H2,1-2H3 BVWLTIOOEFITMA-UHFFFAOYSA-N 50533482 CHEMBL4441252 Serine/threonine-protein kinase PLK1 Homo sapiens 63800 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533482&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7113480 440742064 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51317998 CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16- CMOJHDQJJPIVEC-MNDPQUGUSA-N 50206448 CHEMBL3944542 Serine/threonine-protein kinase PLK1 Homo sapiens 35700 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206448&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9613592 375981109 CHEMBL3944542 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318001 Clc1cc(Cl)cc(\C=N\NC(=O)CCn2c3ccccc3c3ccccc23)c1 InChI=1S/C22H17Cl2N3O/c23-16-11-15(12-17(24)13-16)14-25-26-22(28)9-10-27-20-7-3-1-5-18(20)19-6-2-4-8-21(19)27/h1-8,11-14H,9-10H2,(H,26,28)/b25-14+ HRVYHSZOVIIJMZ-AFUMVMLFSA-N 50533479 CHEMBL4460805 Serine/threonine-protein kinase PLK1 Homo sapiens 339000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533479&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155527682 440742061 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318002 CCc1ccc(\C=N\NC(=O)C2=C(Cl)c3ccc(Cl)cc3C2)s1 InChI=1S/C17H14Cl2N2OS/c1-2-12-4-5-13(23-12)9-20-21-17(22)15-8-10-7-11(18)3-6-14(10)16(15)19/h3-7,9H,2,8H2,1H3,(H,21,22)/b20-9+ AOQXJGFKAZTXFC-AWQFTUOYSA-N 50533477 CHEMBL4439895 Serine/threonine-protein kinase PLK1 Homo sapiens 251000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533477&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155514091 440742059 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318003 CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16- CMOJHDQJJPIVEC-MNDPQUGUSA-N 50206448 CHEMBL3944542 Serine/threonine-protein kinase PLK1 Homo sapiens 408000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206448&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9613592 375981109 CHEMBL3944542 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318004 CCn1c2ccccc2c2cc(\C=N\NC(=O)c3cccc(Cl)c3)ccc12 InChI=1S/C22H18ClN3O/c1-2-26-20-9-4-3-8-18(20)19-12-15(10-11-21(19)26)14-24-25-22(27)16-6-5-7-17(23)13-16/h3-14H,2H2,1H3,(H,25,27)/b24-14+ KLUVBVFLFHBDOC-ZVHZXABRSA-N 50533480 CHEMBL4451672 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533480&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5332523 440742062 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318005 Cc1ccc2nc(C)cc(SCC(=O)N\N=C\c3ccc(Cl)cc3)c2c1 InChI=1S/C20H18ClN3OS/c1-13-3-8-18-17(9-13)19(10-14(2)23-18)26-12-20(25)24-22-11-15-4-6-16(21)7-5-15/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+ LDEMEIWAQMLELB-SSDVNMTOSA-N 50533483 CHEMBL4468878 Serine/threonine-protein kinase PLK1 Homo sapiens 418000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533483&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6875838 440742065 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318006 Cc1ccc(cc1)C(\NC(=S)Nc1ccc(cc1)[N+]([O-])=O)=N\CS(=O)(=O)c1ccccc1 InChI=1S/C22H20N4O4S2/c1-16-7-9-17(10-8-16)21(23-15-32(29,30)20-5-3-2-4-6-20)25-22(31)24-18-11-13-19(14-12-18)26(27)28/h2-14H,15H2,1H3,(H2,23,24,25,31) KKVDMCHUTIDAMV-UHFFFAOYSA-N 50533484 CHEMBL4553039 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533484&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5717789 440742066 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318008 Cc1ccccc1OCC(=O)N\N=C\c1ccc2OCCOc2c1 InChI=1S/C18H18N2O4/c1-13-4-2-3-5-15(13)24-12-18(21)20-19-11-14-6-7-16-17(10-14)23-9-8-22-16/h2-7,10-11H,8-9,12H2,1H3,(H,20,21)/b19-11+ LUYKDALVAGNUCX-YBFXNURJSA-N 50533478 CHEMBL1965126 Serine/threonine-protein kinase PLK1 Homo sapiens 412000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533478&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6871427 440742060 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318009 Cc1ccc(cc1)C(\NC(=S)Nc1ccc(cc1)[N+]([O-])=O)=N\CS(=O)(=O)c1ccccc1 InChI=1S/C22H20N4O4S2/c1-16-7-9-17(10-8-16)21(23-15-32(29,30)20-5-3-2-4-6-20)25-22(31)24-18-11-13-19(14-12-18)26(27)28/h2-14H,15H2,1H3,(H2,23,24,25,31) KKVDMCHUTIDAMV-UHFFFAOYSA-N 50533484 CHEMBL4553039 Serine/threonine-protein kinase PLK1 Homo sapiens 57800 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533484&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5717789 440742066 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318011 Brc1ccc(\C=N\NC(=O)c2n[nH]c3CCCCc23)cc1 InChI=1S/C15H15BrN4O/c16-11-7-5-10(6-8-11)9-17-20-15(21)14-12-3-1-2-4-13(12)18-19-14/h5-9H,1-4H2,(H,18,19)(H,20,21)/b17-9+ SLFDXBVSQBPXOA-RQZCQDPDSA-N 50533485 CHEMBL4587212 Serine/threonine-protein kinase PLK1 Homo sapiens 34700 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533485&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6862977 440742067 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318012 Cc1ccc2nc(C)cc(SCC(=O)N\N=C\c3ccc(Cl)cc3)c2c1 InChI=1S/C20H18ClN3OS/c1-13-3-8-18-17(9-13)19(10-14(2)23-18)26-12-20(25)24-22-11-15-4-6-16(21)7-5-15/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+ LDEMEIWAQMLELB-SSDVNMTOSA-N 50533483 CHEMBL4468878 Serine/threonine-protein kinase PLK1 Homo sapiens 65900 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533483&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 6875838 440742065 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51318013 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C24H40N7O11P/c1-4-12(2)18(30-20(33)15-6-5-7-26-15)23(36)28-16(8-14-9-25-11-27-14)21(34)29-17(10-32)22(35)31-19(24(37)38)13(3)42-43(39,40)41/h9,11-13,15-19,26,32H,4-8,10H2,1-3H3,(H,25,27)(H,28,36)(H,29,34)(H,30,33)(H,31,35)(H,37,38)(H2,39,40,41)/t12-,13+,15-,16-,17-,18-,19-/m0/s1 HZSHQOFHLAXPOK-JTIJSBBYSA-N 50533486 CHEMBL4447981 Serine/threonine-protein kinase PLK1 Homo sapiens 23000 ChEMBL 10.1021/acs.jmedchem.6b00261 10.7270/Q2PR80GQ 27425654 Qin, T; Chen, F; Zhuo, X; Guo, X; Yun, T; Liu, Y; Zhang, C; Lai, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50533486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50533486&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155519894 440742068 C00615 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291098 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3cccc(Cl)c3)c2n1)C1CCN(C)CC1 InChI=1S/C30H37ClN6O2/c1-5-25-29(38)36(4)26-18-32-30(34-28(26)37(25)19-20-8-7-9-23(31)16-20)33-24-11-10-22(17-27(24)39-6-2)21-12-14-35(3)15-13-21/h7-11,16-18,21,25H,5-6,12-15,19H2,1-4H3,(H,32,33,34)/t25-/m1/s1 DTKNQMRYSGVPEX-RUZDIDTESA-N 50526297 CHEMBL4448214 Serine/threonine-protein kinase PLK1 Homo sapiens 540 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526297&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155519748 440734879 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298060 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C28H37FN6O4/c1-3-22-27(38)34(2)23-16-30-28(33-25(23)35(22)18-10-6-7-11-18)32-21-15-20(29)19(14-24(21)39-13-12-36)26(37)31-17-8-4-5-9-17/h14-18,22,36H,3-13H2,1-2H3,(H,31,37)(H,30,32,33)/t22-/m1/s1 OSCRFGZIFNWYIZ-JOCHJYFZSA-N 50529084 CHEMBL4458460 Serine/threonine-protein kinase PLK1 Homo sapiens 3.9 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529084&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155526889 440737666 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298062 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCCC3)ncc2N(COC)C1=O InChI=1S/C28H38N6O4/c1-4-22-27(36)33(17-37-2)23-16-29-28(32-25(23)34(22)20-11-7-8-12-20)31-21-14-13-18(15-24(21)38-3)26(35)30-19-9-5-6-10-19/h13-16,19-20,22H,4-12,17H2,1-3H3,(H,30,35)(H,29,31,32)/t22-/m1/s1 CPKXJSCSFMHODF-JOCHJYFZSA-N 50529085 CHEMBL4524869 Serine/threonine-protein kinase PLK1 Homo sapiens 1200 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155538752 440737667 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298063 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(C)=O)ncc2N(C)C1=O InChI=1S/C24H31N5O4/c1-4-19-23(32)28(3)20-14-25-24(27-22(20)29(19)17-7-5-6-8-17)26-18-10-9-16(15(2)31)13-21(18)33-12-11-30/h9-10,13-14,17,19,30H,4-8,11-12H2,1-3H3,(H,25,26,27)/t19-/m1/s1 MAULBJVKJOGNGD-LJQANCHMSA-N 50529082 CHEMBL4447251 Serine/threonine-protein kinase PLK1 Homo sapiens 5.8 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529082&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155519091 440737664 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298064 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NCCN(C)C)ncc2N(C)C1=O InChI=1S/C27H39N7O4/c1-5-21-26(37)33(4)22-17-29-27(31-24(22)34(21)19-8-6-7-9-19)30-20-11-10-18(16-23(20)38-15-14-35)25(36)28-12-13-32(2)3/h10-11,16-17,19,21,35H,5-9,12-15H2,1-4H3,(H,28,36)(H,29,30,31)/t21-/m1/s1 LDFXILCAFQHTNH-OAQYLSRUSA-N 50529086 CHEMBL4449123 Serine/threonine-protein kinase PLK1 Homo sapiens 38 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529086&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451370 440737668 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298080 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C27H36N6O3/c1-4-21-26(35)32(2)22-16-28-27(31-24(22)33(21)19-11-7-8-12-19)30-20-14-13-17(15-23(20)36-3)25(34)29-18-9-5-6-10-18/h13-16,18-19,21H,4-12H2,1-3H3,(H,29,34)(H,28,30,31)/t21-/m1/s1 XANXBCMPWPUNSZ-OAQYLSRUSA-N 50529099 CHEMBL4592698 Serine/threonine-protein kinase PLK1 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529099&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155568979 440737681 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298081 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCCC3)ncc2NC1=O InChI=1S/C26H34N6O3/c1-3-21-25(34)29-20-15-27-26(31-23(20)32(21)18-10-6-7-11-18)30-19-13-12-16(14-22(19)35-2)24(33)28-17-8-4-5-9-17/h12-15,17-18,21H,3-11H2,1-2H3,(H,28,33)(H,29,34)(H,27,30,31)/t21-/m1/s1 JTYDPPQNZSHIQR-OAQYLSRUSA-N 50529081 CHEMBL4450564 Serine/threonine-protein kinase PLK1 Homo sapiens 52 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529081&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155520963 440737663 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298082 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3O)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C26H34N6O3/c1-3-20-25(35)31(2)21-15-27-26(30-23(21)32(20)18-10-6-7-11-18)29-19-13-12-16(14-22(19)33)24(34)28-17-8-4-5-9-17/h12-15,17-18,20,33H,3-11H2,1-2H3,(H,28,34)(H,27,29,30)/t20-/m1/s1 JYYQJHRWOKIHGC-HXUWFJFHSA-N 50529100 CHEMBL4548940 Serine/threonine-protein kinase PLK1 Homo sapiens 5.9 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529100&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155549112 440737682 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298083 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCOC)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C29H40N6O4/c1-4-23-28(37)34(2)24-18-30-29(33-26(24)35(23)21-11-7-8-12-21)32-22-14-13-19(17-25(22)39-16-15-38-3)27(36)31-20-9-5-6-10-20/h13-14,17-18,20-21,23H,4-12,15-16H2,1-3H3,(H,31,36)(H,30,32,33)/t23-/m1/s1 MKMWADKTKCUOBJ-HSZRJFAPSA-N 50529101 CHEMBL4587599 Serine/threonine-protein kinase PLK1 Homo sapiens 345 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529101&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155566593 440737683 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298084 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C28H38N6O4/c1-3-22-27(37)33(2)23-17-29-28(32-25(23)34(22)20-10-6-7-11-20)31-21-13-12-18(16-24(21)38-15-14-35)26(36)30-19-8-4-5-9-19/h12-13,16-17,19-20,22,35H,3-11,14-15H2,1-2H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 JKZKKHVTLCFCGS-JOCHJYFZSA-N 50529102 CHEMBL4531932 Serine/threonine-protein kinase PLK1 Homo sapiens 9.3 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529102&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155546554 440737684 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298085 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C29H41N7O4/c1-4-23-28(39)35(3)24-18-30-29(33-26(24)36(23)21-7-5-6-8-21)32-22-10-9-19(17-25(22)40-16-15-37)27(38)31-20-11-13-34(2)14-12-20/h9-10,17-18,20-21,23,37H,4-8,11-16H2,1-3H3,(H,31,38)(H,30,32,33)/t23-/m1/s1 ZAJAQZFUONWQPQ-HSZRJFAPSA-N 50529103 CHEMBL4450624 Serine/threonine-protein kinase PLK1 Homo sapiens 4.3 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529103&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155521348 440737685 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298086 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(N)=O)ncc2N(C)C1=O InChI=1S/C23H30N6O4/c1-3-17-22(32)28(2)18-13-25-23(27-21(18)29(17)15-6-4-5-7-15)26-16-9-8-14(20(24)31)12-19(16)33-11-10-30/h8-9,12-13,15,17,30H,3-7,10-11H2,1-2H3,(H2,24,31)(H,25,26,27)/t17-/m1/s1 RNCCSJOQZGLCIQ-QGZVFWFLSA-N 50529104 CHEMBL4461041 Serine/threonine-protein kinase PLK1 Homo sapiens 21 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529104&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155528462 440737686 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298087 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NC)ncc2N(C)C1=O InChI=1S/C24H32N6O4/c1-4-18-23(33)29(3)19-14-26-24(28-21(19)30(18)16-7-5-6-8-16)27-17-10-9-15(22(32)25-2)13-20(17)34-12-11-31/h9-10,13-14,16,18,31H,4-8,11-12H2,1-3H3,(H,25,32)(H,26,27,28)/t18-/m1/s1 PGHXJQMSVOKZRE-GOSISDBHSA-N 50529105 CHEMBL4566834 Serine/threonine-protein kinase PLK1 Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529105&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155543442 440737687 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298088 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NC(C)C)ncc2N(C)C1=O InChI=1S/C26H36N6O4/c1-5-20-25(35)31(4)21-15-27-26(30-23(21)32(20)18-8-6-7-9-18)29-19-11-10-17(24(34)28-16(2)3)14-22(19)36-13-12-33/h10-11,14-16,18,20,33H,5-9,12-13H2,1-4H3,(H,28,34)(H,27,29,30)/t20-/m1/s1 ITYGFIRONBGARW-HXUWFJFHSA-N 50529106 CHEMBL4448563 Serine/threonine-protein kinase PLK1 Homo sapiens 6.9 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529106&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155519344 440737688 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298089 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CC3)ncc2N(C)C1=O InChI=1S/C26H34N6O4/c1-3-20-25(35)31(2)21-15-27-26(30-23(21)32(20)18-6-4-5-7-18)29-19-11-8-16(14-22(19)36-13-12-33)24(34)28-17-9-10-17/h8,11,14-15,17-18,20,33H,3-7,9-10,12-13H2,1-2H3,(H,28,34)(H,27,29,30)/t20-/m1/s1 QIMUQYHRHHNTNY-HXUWFJFHSA-N 50529088 CHEMBL4574255 Serine/threonine-protein kinase PLK1 Homo sapiens 30 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529088&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155564098 440737670 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298090 CCCCNC(=O)c1ccc(Nc2ncc3N(C)C(=O)[C@@H](CC)N(C4CCCC4)c3n2)c(OCCO)c1 InChI=1S/C27H38N6O4/c1-4-6-13-28-25(35)18-11-12-20(23(16-18)37-15-14-34)30-27-29-17-22-24(31-27)33(19-9-7-8-10-19)21(5-2)26(36)32(22)3/h11-12,16-17,19,21,34H,4-10,13-15H2,1-3H3,(H,28,35)(H,29,30,31)/t21-/m1/s1 RJERVODZSCACGJ-OAQYLSRUSA-N 50529089 CHEMBL4453584 Serine/threonine-protein kinase PLK1 Homo sapiens 35 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529089&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451383 440737671 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298091 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C26H36N6O4/c1-5-20-25(35)31(4)21-15-27-26(30-23(21)32(20)16(2)3)29-19-11-10-17(14-22(19)36-13-12-33)24(34)28-18-8-6-7-9-18/h10-11,14-16,18,20,33H,5-9,12-13H2,1-4H3,(H,28,34)(H,27,29,30)/t20-/m1/s1 RTXCCFIAPPYLHZ-HXUWFJFHSA-N 50529083 CHEMBL4473297 Serine/threonine-protein kinase PLK1 Homo sapiens 126 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529083&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155536170 440737665 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298092 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C27H39N7O4/c1-6-21-26(37)33(5)22-16-28-27(31-24(22)34(21)17(2)3)30-20-8-7-18(15-23(20)38-14-13-35)25(36)29-19-9-11-32(4)12-10-19/h7-8,15-17,19,21,35H,6,9-14H2,1-5H3,(H,29,36)(H,28,30,31)/t21-/m1/s1 NJYIKUBUVYJEPA-OAQYLSRUSA-N 50529091 CHEMBL4449490 Serine/threonine-protein kinase PLK1 Homo sapiens 124 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529091&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155520726 440737673 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298093 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC3CCOCC3)ncc2N(C)C1=O InChI=1S/C28H37FN6O5/c1-3-22-27(38)34(2)23-16-30-28(33-25(23)35(22)18-6-4-5-7-18)32-21-15-20(29)19(14-24(21)40-13-10-36)26(37)31-17-8-11-39-12-9-17/h14-18,22,36H,3-13H2,1-2H3,(H,31,37)(H,30,32,33)/t22-/m1/s1 MVYFNZROIDKPOZ-JOCHJYFZSA-N 50529093 CHEMBL4441121 Serine/threonine-protein kinase PLK1 Homo sapiens 5.1 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155514946 440737675 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298094 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC)ncc2N(C)C1=O InChI=1S/C24H31FN6O4/c1-4-18-23(34)30(3)19-13-27-24(29-21(19)31(18)14-7-5-6-8-14)28-17-12-16(25)15(22(33)26-2)11-20(17)35-10-9-32/h11-14,18,32H,4-10H2,1-3H3,(H,26,33)(H,27,28,29)/t18-/m1/s1 FTVMYIRRFFYFIH-GOSISDBHSA-N 50529107 CHEMBL4456400 Serine/threonine-protein kinase PLK1 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529107&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155524979 440737689 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298095 CCNC(=O)c1cc(OCCO)c(Nc2ncc3N(C)C(=O)[C@@H](CC)N(C4CCCC4)c3n2)cc1F InChI=1S/C25H33FN6O4/c1-4-19-24(35)31(3)20-14-28-25(30-22(20)32(19)15-8-6-7-9-15)29-18-13-17(26)16(23(34)27-5-2)12-21(18)36-11-10-33/h12-15,19,33H,4-11H2,1-3H3,(H,27,34)(H,28,29,30)/t19-/m1/s1 VINNOSMQDSWDTC-LJQANCHMSA-N 50529094 CHEMBL4570557 Serine/threonine-protein kinase PLK1 Homo sapiens 8.0 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529094&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155562825 440737676 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298096 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NCCN3CCOCC3)ncc2N(C)C1=O InChI=1S/C29H40FN7O5/c1-3-23-28(40)35(2)24-18-32-29(34-26(24)37(23)19-6-4-5-7-19)33-22-17-21(30)20(16-25(22)42-15-12-38)27(39)31-8-9-36-10-13-41-14-11-36/h16-19,23,38H,3-15H2,1-2H3,(H,31,39)(H,32,33,34)/t23-/m1/s1 NCCZKHZUPCPIOT-HSZRJFAPSA-N 50529095 CHEMBL4573833 Serine/threonine-protein kinase PLK1 Homo sapiens 20 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155563487 440737677 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298097 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NCCN(C)C)ncc2N(C)C1=O InChI=1S/C27H38FN7O4/c1-5-21-26(38)34(4)22-16-30-27(32-24(22)35(21)17-8-6-7-9-17)31-20-15-19(28)18(14-23(20)39-13-12-36)25(37)29-10-11-33(2)3/h14-17,21,36H,5-13H2,1-4H3,(H,29,37)(H,30,31,32)/t21-/m1/s1 VQBDOEAPEQAQSE-OAQYLSRUSA-N 50529108 CHEMBL4515755 Serine/threonine-protein kinase PLK1 Homo sapiens 127 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529108&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155539913 440737690 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298098 CC[C@H]1N(C(C)C)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC3CCOCC3)ncc2N(C)C1=O InChI=1S/C26H35FN6O5/c1-5-20-25(36)32(4)21-14-28-26(31-23(21)33(20)15(2)3)30-19-13-18(27)17(12-22(19)38-11-8-34)24(35)29-16-6-9-37-10-7-16/h12-16,20,34H,5-11H2,1-4H3,(H,29,35)(H,28,30,31)/t20-/m1/s1 IJDPNONZYDDAHT-HXUWFJFHSA-N 50529097 CHEMBL4541823 Serine/threonine-protein kinase PLK1 Homo sapiens 53 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529097&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155551215 440737679 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298099 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 7.1 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298131 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3C)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C27H36N6O2/c1-4-22-26(35)32(3)23-16-28-27(31-24(23)33(22)20-11-7-8-12-20)30-21-14-13-18(15-17(21)2)25(34)29-19-9-5-6-10-19/h13-16,19-20,22H,4-12H2,1-3H3,(H,29,34)(H,28,30,31)/t22-/m1/s1 OCYISXRMEJNANP-JOCHJYFZSA-N 50529109 CHEMBL4454222 Serine/threonine-protein kinase PLK1 Homo sapiens 5.8 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529109&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451369 440737691 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298132 CCCNC(=O)c1ccc(Nc2ncc3N(C)C(=O)[C@@H](CC)N(C4CCCC4)c3n2)c(OCCO)c1 InChI=1S/C26H36N6O4/c1-4-12-27-24(34)17-10-11-19(22(15-17)36-14-13-33)29-26-28-16-21-23(30-26)32(18-8-6-7-9-18)20(5-2)25(35)31(21)3/h10-11,15-16,18,20,33H,4-9,12-14H2,1-3H3,(H,27,34)(H,28,29,30)/t20-/m1/s1 NTVFVNYEAMJGDF-HXUWFJFHSA-N 50529113 CHEMBL4574072 Serine/threonine-protein kinase PLK1 Homo sapiens 41 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529113&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451384 440737695 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298133 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CCOCC3)ncc2N(C)C1=O InChI=1S/C26H36N6O5/c1-5-20-25(35)31(4)21-15-27-26(30-23(21)32(20)16(2)3)29-19-7-6-17(14-22(19)37-13-10-33)24(34)28-18-8-11-36-12-9-18/h6-7,14-16,18,20,33H,5,8-13H2,1-4H3,(H,28,34)(H,27,29,30)/t20-/m1/s1 SABCSWBSIQGESJ-HXUWFJFHSA-N 50529115 CHEMBL4469319 Serine/threonine-protein kinase PLK1 Homo sapiens 177 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529115&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155533912 440737697 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298134 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NCCN3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C30H43FN8O4/c1-4-24-29(42)37(3)25-19-33-30(35-27(25)39(24)20-7-5-6-8-20)34-23-18-22(31)21(17-26(23)43-16-15-40)28(41)32-9-10-38-13-11-36(2)12-14-38/h17-20,24,40H,4-16H2,1-3H3,(H,32,41)(H,33,34,35)/t24-/m1/s1 QMGCOLHGTKYVOP-XMMPIXPASA-N 50529080 CHEMBL4447495 Serine/threonine-protein kinase PLK1 Homo sapiens 10 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529080&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155519017 440737662 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298142 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3CCO)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C28H38N6O3/c1-3-23-27(37)33(2)24-17-29-28(32-25(24)34(23)21-10-6-7-11-21)31-22-13-12-19(16-18(22)14-15-35)26(36)30-20-8-4-5-9-20/h12-13,16-17,20-21,23,35H,3-11,14-15H2,1-2H3,(H,30,36)(H,29,31,32)/t23-/m1/s1 CAVRDKDHKZOOIF-HSZRJFAPSA-N 50529110 CHEMBL4436925 Serine/threonine-protein kinase PLK1 Homo sapiens 10 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529110&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 141451387 440737692 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298143 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NCCN3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C30H44N8O4/c1-4-24-29(41)36(3)25-20-32-30(34-27(25)38(24)22-7-5-6-8-22)33-23-10-9-21(19-26(23)42-18-17-39)28(40)31-11-12-37-15-13-35(2)14-16-37/h9-10,19-20,22,24,39H,4-8,11-18H2,1-3H3,(H,31,40)(H,32,33,34)/t24-/m1/s1 MVOGKCYGDBWOLZ-XMMPIXPASA-N 50529114 CHEMBL4576641 Serine/threonine-protein kinase PLK1 Homo sapiens 21 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529114&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155553924 440737696 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298144 CC[C@H]1N(C(C)C)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C27H38FN7O4/c1-6-21-26(38)34(5)22-15-29-27(32-24(22)35(21)16(2)3)31-20-14-19(28)18(13-23(20)39-12-11-36)25(37)30-17-7-9-33(4)10-8-17/h13-17,21,36H,6-12H2,1-5H3,(H,30,37)(H,29,31,32)/t21-/m1/s1 MLSKNMPNUOPUAB-OAQYLSRUSA-N 50529096 CHEMBL4442768 Serine/threonine-protein kinase PLK1 Homo sapiens 27 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529096&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155516034 440737678 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298155 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CCN(CC3)C(C)C)ncc2N(C)C1=O InChI=1S/C31H45N7O4/c1-5-25-30(41)36(4)26-19-32-31(35-28(26)38(25)23-8-6-7-9-23)34-24-11-10-21(18-27(24)42-17-16-39)29(40)33-22-12-14-37(15-13-22)20(2)3/h10-11,18-20,22-23,25,39H,5-9,12-17H2,1-4H3,(H,33,40)(H,32,34,35)/t25-/m1/s1 YXRJOXHIGGNCBU-RUZDIDTESA-N 50529087 CHEMBL4515187 Serine/threonine-protein kinase PLK1 Homo sapiens 17 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529087&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155539415 440737669 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298156 CCC1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C28H37FN6O4/c1-3-22-27(38)34(2)23-16-30-28(33-25(23)35(22)18-10-6-7-11-18)32-21-15-20(29)19(14-24(21)39-13-12-36)26(37)31-17-8-4-5-9-17/h14-18,22,36H,3-13H2,1-2H3,(H,31,37)(H,30,32,33) OSCRFGZIFNWYIZ-UHFFFAOYSA-N 50529098 CHEMBL4465062 Serine/threonine-protein kinase PLK1 Homo sapiens 7.3 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529098&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155530844 440737680 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298159 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCCC3)ncc2N(CCO)C1=O InChI=1S/C28H38N6O4/c1-3-22-27(37)33(14-15-35)23-17-29-28(32-25(23)34(22)20-10-6-7-11-20)31-21-13-12-18(16-24(21)38-2)26(36)30-19-8-4-5-9-19/h12-13,16-17,19-20,22,35H,3-11,14-15H2,1-2H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 RXUHANPBMLBQKI-JOCHJYFZSA-N 50529117 CHEMBL4468970 Serine/threonine-protein kinase PLK1 Homo sapiens 292 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529117&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155533233 440737699 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298160 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCc3ccccc3)C(=O)NC3CCCC3)ncc2N(C)C1=O InChI=1S/C33H40N6O3/c1-3-27-32(41)38(2)28-20-34-33(37-30(28)39(27)25-15-9-10-16-25)36-26-18-17-23(31(40)35-24-13-7-8-14-24)19-29(26)42-21-22-11-5-4-6-12-22/h4-6,11-12,17-20,24-25,27H,3,7-10,13-16,21H2,1-2H3,(H,35,40)(H,34,36,37)/t27-/m1/s1 FUNAYLLIFYNRND-HHHXNRCGSA-N 50529118 CHEMBL4454586 Serine/threonine-protein kinase PLK1 Homo sapiens 885 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529118&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155523554 440737700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298161 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NC3CCOCC3)ncc2N(C)C1=O InChI=1S/C28H38N6O5/c1-3-22-27(37)33(2)23-17-29-28(32-25(23)34(22)20-6-4-5-7-20)31-21-9-8-18(16-24(21)39-15-12-35)26(36)30-19-10-13-38-14-11-19/h8-9,16-17,19-20,22,35H,3-7,10-15H2,1-2H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 FVLMDPWEHBGZDD-JOCHJYFZSA-N 50529111 CHEMBL4519294 Serine/threonine-protein kinase PLK1 Homo sapiens 9.4 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529111&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155541766 440737693 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298162 CCNC(=O)c1ccc(Nc2ncc3N(C)C(=O)[C@@H](CC)N(C4CCCC4)c3n2)c(OCCO)c1 InChI=1S/C25H34N6O4/c1-4-19-24(34)30(3)20-15-27-25(29-22(20)31(19)17-8-6-7-9-17)28-18-11-10-16(23(33)26-5-2)14-21(18)35-13-12-32/h10-11,14-15,17,19,32H,4-9,12-13H2,1-3H3,(H,26,33)(H,27,28,29)/t19-/m1/s1 AILANCLYZDKELS-LJQANCHMSA-N 50529112 CHEMBL4545446 Serine/threonine-protein kinase PLK1 Homo sapiens 21 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529112&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155552906 440737694 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298163 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OCCO)C(=O)NCCN3CCOCC3)ncc2N(C)C1=O InChI=1S/C29H41N7O5/c1-3-23-28(39)34(2)24-19-31-29(33-26(24)36(23)21-6-4-5-7-21)32-22-9-8-20(18-25(22)41-17-14-37)27(38)30-10-11-35-12-15-40-16-13-35/h8-9,18-19,21,23,37H,3-7,10-17H2,1-2H3,(H,30,38)(H,31,32,33)/t23-/m1/s1 NERSFQYNEXMEPK-HSZRJFAPSA-N 50529090 CHEMBL4529398 Serine/threonine-protein kinase PLK1 Homo sapiens 18 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529090&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155545273 440737672 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298164 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C29H40FN7O4/c1-4-23-28(40)36(3)24-17-31-29(34-26(24)37(23)19-7-5-6-8-19)33-22-16-21(30)20(15-25(22)41-14-13-38)27(39)32-18-9-11-35(2)12-10-18/h15-19,23,38H,4-14H2,1-3H3,(H,32,39)(H,31,33,34)/t23-/m1/s1 AAWUJXDNCDOXTN-HSZRJFAPSA-N 50529092 CHEMBL4459892 Serine/threonine-protein kinase PLK1 Homo sapiens 3.6 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529092&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155527327 440737674 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298165 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc(F)c(cc3OCCO)C(=O)NC(C)C)ncc2N(C)C1=O InChI=1S/C26H35FN6O4/c1-5-20-25(36)32(4)21-14-28-26(31-23(21)33(20)16-8-6-7-9-16)30-19-13-18(27)17(24(35)29-15(2)3)12-22(19)37-11-10-34/h12-16,20,34H,5-11H2,1-4H3,(H,29,35)(H,28,30,31)/t20-/m1/s1 VZDOSGQBGHVVCU-HXUWFJFHSA-N 50529116 CHEMBL4457656 Serine/threonine-protein kinase PLK1 Homo sapiens 7.2 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529116&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155525853 440737698 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51298166 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 865 ChEMBL 10.1016/j.ejmech.2019.111769 10.7270/Q290278N 31629162 Lv, X; Yang, X; Zhan, MM; Cao, P; Zheng, S; Peng, R; Han, J; Xie, Z; Tu, Z; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291121 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens <2.6 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291122 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C29H41N7O3/c1-5-23-28(38)35(4)24-18-30-29(33-26(24)36(23)21-9-7-8-10-21)32-22-12-11-19(17-25(22)39-6-2)27(37)31-20-13-15-34(3)16-14-20/h11-12,17-18,20-21,23H,5-10,13-16H2,1-4H3,(H,31,37)(H,30,32,33)/t23-/m1/s1 DBBQRLYYNNWGPM-HSZRJFAPSA-N 50526302 CHEMBL4464826 Serine/threonine-protein kinase PLK1 Homo sapiens 12 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526302&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 58009759 440734884 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291123 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3cccc(Br)c3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C31H38BrN7O3/c1-5-25-30(41)38(4)26-18-33-31(36-28(26)39(25)19-20-8-7-9-22(32)16-20)35-24-11-10-21(17-27(24)42-6-2)29(40)34-23-12-14-37(3)15-13-23/h7-11,16-18,23,25H,5-6,12-15,19H2,1-4H3,(H,34,40)(H,33,35,36)/t25-/m1/s1 NQROQCRXQDNZSD-RUZDIDTESA-N 50526300 CHEMBL4469756 Serine/threonine-protein kinase PLK1 Homo sapiens 110 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526300&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155533569 440734882 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291124 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3ccccc3)c2n1)C(=O)NC1CCN(C)CC1 InChI=1S/C31H39N7O3/c1-5-25-30(40)37(4)26-19-32-31(35-28(26)38(25)20-21-10-8-7-9-11-21)34-24-13-12-22(18-27(24)41-6-2)29(39)33-23-14-16-36(3)17-15-23/h7-13,18-19,23,25H,5-6,14-17,20H2,1-4H3,(H,33,39)(H,32,34,35)/t25-/m1/s1 LYAOPUXRPJKSKW-RUZDIDTESA-N 50526303 CHEMBL4457809 Serine/threonine-protein kinase PLK1 Homo sapiens 84 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526303&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155525411 440734885 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291125 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3ccccc3)c2n1)C1CCN(C)CC1 InChI=1S/C30H38N6O2/c1-5-25-29(37)35(4)26-19-31-30(33-28(26)36(25)20-21-10-8-7-9-11-21)32-24-13-12-23(18-27(24)38-6-2)22-14-16-34(3)17-15-22/h7-13,18-19,22,25H,5-6,14-17,20H2,1-4H3,(H,31,32,33)/t25-/m1/s1 TWABWUVZWXSPTC-RUZDIDTESA-N 50526295 CHEMBL4469087 Serine/threonine-protein kinase PLK1 Homo sapiens 290 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526295&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search HG5 6Q3Y 137347775 440734877 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291126 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3cccc(c3)C#N)c2n1)C1CCN(C)CC1 InChI=1S/C31H37N7O2/c1-5-26-30(39)37(4)27-19-33-31(35-29(27)38(26)20-22-9-7-8-21(16-22)18-32)34-25-11-10-24(17-28(25)40-6-2)23-12-14-36(3)15-13-23/h7-11,16-17,19,23,26H,5-6,12-15,20H2,1-4H3,(H,33,34,35)/t26-/m1/s1 WDADYPXHXOFAQY-AREMUKBSSA-N 50526294 CHEMBL4588843 Serine/threonine-protein kinase PLK1 Homo sapiens 1800 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526294&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155567235 440734876 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291127 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3cc(C)cs3)c2n1)C1CCN(C)CC1 InChI=1S/C29H38N6O2S/c1-6-24-28(36)34(5)25-16-30-29(32-27(25)35(24)17-22-14-19(3)18-38-22)31-23-9-8-21(15-26(23)37-7-2)20-10-12-33(4)13-11-20/h8-9,14-16,18,20,24H,6-7,10-13,17H2,1-5H3,(H,30,31,32)/t24-/m1/s1 RKWOVOVDWBRGQO-XMMPIXPASA-N 50526296 CHEMBL4449858 Serine/threonine-protein kinase PLK1 Homo sapiens 125 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526296&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search HG8 6Q3Z 137347776 440734878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291138 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3cc(C)cs3)c2n1)C1CCN(C)CC1 InChI=1S/C29H38N6O2S/c1-6-24-28(36)34(5)25-16-30-29(32-27(25)35(24)17-22-14-19(3)18-38-22)31-23-9-8-21(15-26(23)37-7-2)20-10-12-33(4)13-11-20/h8-9,14-16,18,20,24H,6-7,10-13,17H2,1-5H3,(H,30,31,32)/t24-/m1/s1 RKWOVOVDWBRGQO-XMMPIXPASA-N 50526296 CHEMBL4449858 Serine/threonine-protein kinase PLK1 Homo sapiens 0.190000 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526296&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search HG8 6Q3Z 137347776 440734878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291148 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C27H38N6O2/c1-5-22-26(34)32(3)23-17-28-27(30-25(23)33(22)20-8-6-7-9-20)29-21-11-10-19(16-24(21)35-4)18-12-14-31(2)15-13-18/h10-11,16-18,20,22H,5-9,12-15H2,1-4H3,(H,28,29,30)/t22-/m1/s1 WCMQEPUDHFATFM-JOCHJYFZSA-N 50526301 CHEMBL4456099 Serine/threonine-protein kinase PLK1 Homo sapiens 9.9 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526301&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155525053 440734883 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291149 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3cccc(Br)c3)c2n1)C1CCN(C)CC1 InChI=1S/C30H37BrN6O2/c1-5-25-29(38)36(4)26-18-32-30(34-28(26)37(25)19-20-8-7-9-23(31)16-20)33-24-11-10-22(17-27(24)39-6-2)21-12-14-35(3)15-13-21/h7-11,16-18,21,25H,5-6,12-15,19H2,1-4H3,(H,32,33,34)/t25-/m1/s1 KPXMSUZHJCHOTN-RUZDIDTESA-N 50526304 CHEMBL4451065 Serine/threonine-protein kinase PLK1 Homo sapiens 540 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526304&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155522472 440734886 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291150 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3sccc3C)c2n1)C1CCN(C)CC1 InChI=1S/C29H38N6O2S/c1-6-23-28(36)34(5)24-17-30-29(32-27(24)35(23)18-26-19(3)12-15-38-26)31-22-9-8-21(16-25(22)37-7-2)20-10-13-33(4)14-11-20/h8-9,12,15-17,20,23H,6-7,10-11,13-14,18H2,1-5H3,(H,30,31,32)/t23-/m1/s1 IJNMRIYHRCSVCO-HSZRJFAPSA-N 50526309 CHEMBL4543331 Serine/threonine-protein kinase PLK1 Homo sapiens 68 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526309&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 155510533 440734891 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291151 CCOc1cc(ccc1Nc1ncc2N(C)C(=O)[C@@H](CC)N(Cc3cc(C)cs3)c2n1)C1CCN(C)CC1 InChI=1S/C29H38N6O2S/c1-6-24-28(36)34(5)25-16-30-29(32-27(25)35(24)17-22-14-19(3)18-38-22)31-23-9-8-21(15-26(23)37-7-2)20-10-12-33(4)13-11-20/h8-9,14-16,18,20,24H,6-7,10-13,17H2,1-5H3,(H,30,31,32)/t24-/m1/s1 RKWOVOVDWBRGQO-XMMPIXPASA-N 50526296 CHEMBL4449858 Serine/threonine-protein kinase PLK1 Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526296&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search HG8 6Q3Z 137347776 440734878 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51291154 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.190000 ChEMBL 10.1021/acs.jmedchem.8b01947 10.7270/Q28S4TBZ 30789735 Watts, E; Heidenreich, D; Tucker, E; Raab, M; Strebhardt, K; Chesler, L; Knapp, S; Bellenie, B; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51329036 C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 GXEXIUKEWXZCEF-UMVBOHGHSA-N 50537742 CHEMBL4634634::US11179389, Compound 1-14 Serine/threonine-protein kinase PLK1 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2019.126715 10.7270/Q2HM5CZG 31757666 Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537742&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5D 6OCU 145704650 442139305 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51344304 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase PLK1 Homo sapiens 2.2 ChEMBL 10.1016/j.bmcl.2020.127329 10.7270/Q2Q243TB 32631534 Li, Z; Xu, L; Zhu, L; Zhao, Y; Hu, T; Yin, B; Liu, Y; Hou, Y Shenyang Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51344305 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 0.870000 ChEMBL 10.1016/j.bmcl.2020.127329 10.7270/Q2Q243TB 32631534 Li, Z; Xu, L; Zhu, L; Zhao, Y; Hu, T; Yin, B; Liu, Y; Hou, Y Shenyang Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51344306 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1016/j.bmcl.2020.127329 10.7270/Q2Q243TB 32631534 Li, Z; Xu, L; Zhu, L; Zhao, Y; Hu, T; Yin, B; Liu, Y; Hou, Y Shenyang Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51380436 CC(C)Oc1cc(C2CCN(C)CC2)c(C)cc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2c(C)[nH]nc2n1 InChI=1S/C31H41N7O3S/c1-18(2)41-26-17-23(22-12-14-38(7)15-13-22)20(5)16-25(26)33-31-34-29(28-21(6)36-37-30(28)35-31)32-24-10-8-9-11-27(24)42(39,40)19(3)4/h8-11,16-19,22H,12-15H2,1-7H3,(H3,32,33,34,35,36,37) AFTBNZZMNUUEFO-UHFFFAOYSA-N 107057 US8592432, 34 Serine/threonine-protein kinase PLK1 Homo sapiens 3900 ChEMBL 10.1016/j.bmcl.2015.11.049 10.7270/Q2XS603J 26750252 Michellys, PY; Chen, B; Jiang, T; Jin, Y; Lu, W; Marsilje, TH; Pei, W; Uno, T; Zhu, X; Wu, B; Nguyen, TN; Bursulaya, B; Lee, C; Li, N; Kim, S; Tuntland, T; Liu, B; Sun, F; Steffy, A; Hood, T Genomics Institute of the Novartis Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107057&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44467827 175444504 ZINC96177913 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51382698 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Serine/threonine-protein kinase PLK1 Homo sapiens 76.9 ChEMBL 10.1016/j.bmc.2018.02.022 10.7270/Q2DJ5KB8 29523467 Hou, W; Ren, Y; Zhang, Z; Sun, H; Ma, Y; Yan, B Beijing Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51371700 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H]([C@@H](C)O)C(O)=O 50554672 CHEMBL4758139 Serine/threonine-protein kinase PLK1 Homo sapiens 29020 ChEMBL 10.1021/acs.jmedchem.0c01451 10.7270/Q2W38105 33142063 Gunasekaran, P; Yim, MS; Ahn, M; Soung, NK; Park, JE; Kim, J; Bang, G; Shin, SC; Choi, J; Kim, M; Kim, HN; Lee, YH; Chung, YH; Lee, K; EunKyeong Kim, E; Jeon, YH; Kim, MJ; Lee, KR; Kim, BY; Lee, KS; Ryu, EK; Bang, JK Korea Basic Science Institute (KBSI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50554672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50554672&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656844 461693440 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51371701 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(C)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(N)=O 50554673 CHEMBL4760204 Serine/threonine-protein kinase PLK1 Homo sapiens 230 ChEMBL 10.1021/acs.jmedchem.0c01451 10.7270/Q2W38105 33142063 Gunasekaran, P; Yim, MS; Ahn, M; Soung, NK; Park, JE; Kim, J; Bang, G; Shin, SC; Choi, J; Kim, M; Kim, HN; Lee, YH; Chung, YH; Lee, K; EunKyeong Kim, E; Jeon, YH; Kim, MJ; Lee, KR; Kim, BY; Lee, KS; Ryu, EK; Bang, JK Korea Basic Science Institute (KBSI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50554673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50554673&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162658867 461693441 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51371702 O=C1NC(=O)C(=Cc2cn(nc2-c2ccccc2)-c2ccccc2)C(=O)N1 InChI=1S/C20H14N4O3/c25-18-16(19(26)22-20(27)21-18)11-14-12-24(15-9-5-2-6-10-15)23-17(14)13-7-3-1-4-8-13/h1-12H,(H2,21,22,25,26,27) WOGISSLYRYBUMU-UHFFFAOYSA-N 50554674 CHEMBL4777323 Serine/threonine-protein kinase PLK1 Homo sapiens 32170 ChEMBL 10.1021/acs.jmedchem.0c01451 10.7270/Q2W38105 33142063 Gunasekaran, P; Yim, MS; Ahn, M; Soung, NK; Park, JE; Kim, J; Bang, G; Shin, SC; Choi, J; Kim, M; Kim, HN; Lee, YH; Chung, YH; Lee, K; EunKyeong Kim, E; Jeon, YH; Kim, MJ; Lee, KR; Kim, BY; Lee, KS; Ryu, EK; Bang, JK Korea Basic Science Institute (KBSI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50554674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50554674&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2232587 461693442 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51371703 O=C1NC(=O)C(=Cc2cn(Cc3ccccc3)nc2-c2ccccc2)C(=O)N1 InChI=1S/C21H16N4O3/c26-19-17(20(27)23-21(28)22-19)11-16-13-25(12-14-7-3-1-4-8-14)24-18(16)15-9-5-2-6-10-15/h1-11,13H,12H2,(H2,22,23,26,27,28) WLUDDJLIMNXLSW-UHFFFAOYSA-N 50554675 CHEMBL4792348 Serine/threonine-protein kinase PLK1 Homo sapiens 52700 ChEMBL 10.1021/acs.jmedchem.0c01451 10.7270/Q2W38105 33142063 Gunasekaran, P; Yim, MS; Ahn, M; Soung, NK; Park, JE; Kim, J; Bang, G; Shin, SC; Choi, J; Kim, M; Kim, HN; Lee, YH; Chung, YH; Lee, K; EunKyeong Kim, E; Jeon, YH; Kim, MJ; Lee, KR; Kim, BY; Lee, KS; Ryu, EK; Bang, JK Korea Basic Science Institute (KBSI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50554675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50554675&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162672281 461693443 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51371704 CNc1ccc(cc1)C(=O)NCCn1cc(C=C2C(=O)NC(=O)NC2=O)c(n1)-c1ccccc1 InChI=1S/C24H22N6O4/c1-25-18-9-7-16(8-10-18)21(31)26-11-12-30-14-17(20(29-30)15-5-3-2-4-6-15)13-19-22(32)27-24(34)28-23(19)33/h2-10,13-14,25H,11-12H2,1H3,(H,26,31)(H2,27,28,32,33,34) WEWSXPJRYDQPAO-UHFFFAOYSA-N 50554676 CHEMBL4788427 Serine/threonine-protein kinase PLK1 Homo sapiens 16350 ChEMBL 10.1021/acs.jmedchem.0c01451 10.7270/Q2W38105 33142063 Gunasekaran, P; Yim, MS; Ahn, M; Soung, NK; Park, JE; Kim, J; Bang, G; Shin, SC; Choi, J; Kim, M; Kim, HN; Lee, YH; Chung, YH; Lee, K; EunKyeong Kim, E; Jeon, YH; Kim, MJ; Lee, KR; Kim, BY; Lee, KS; Ryu, EK; Bang, JK Korea Basic Science Institute (KBSI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50554676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50554676&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668621 461693444 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51371705 O=C1NC(=O)C(=Cc2cn(CCN3CCOCC3)nc2-c2ccccc2)C(=O)N1 InChI=1S/C20H21N5O4/c26-18-16(19(27)22-20(28)21-18)12-15-13-25(7-6-24-8-10-29-11-9-24)23-17(15)14-4-2-1-3-5-14/h1-5,12-13H,6-11H2,(H2,21,22,26,27,28) GMAROWAEERKBHQ-UHFFFAOYSA-N 50554677 CHEMBL4765111 Serine/threonine-protein kinase PLK1 Homo sapiens 71030 ChEMBL 10.1021/acs.jmedchem.0c01451 10.7270/Q2W38105 33142063 Gunasekaran, P; Yim, MS; Ahn, M; Soung, NK; Park, JE; Kim, J; Bang, G; Shin, SC; Choi, J; Kim, M; Kim, HN; Lee, YH; Chung, YH; Lee, K; EunKyeong Kim, E; Jeon, YH; Kim, MJ; Lee, KR; Kim, BY; Lee, KS; Ryu, EK; Bang, JK Korea Basic Science Institute (KBSI) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50554677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50554677&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162660834 461693445 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51368323 NS(=O)(=O)c1ccc(Nc2nc(C#C)c3nc[nH]c3n2)cc1 InChI=1S/C13H10N6O2S/c1-2-10-11-12(16-7-15-11)19-13(18-10)17-8-3-5-9(6-4-8)22(14,20)21/h1,3-7H,(H2,14,20,21)(H2,15,16,17,18,19) IOGIUPJAOMXLRJ-UHFFFAOYSA-N 50235361 CHEMBL4074015 Serine/threonine-protein kinase PLK1 Homo sapiens 33700 ChEMBL 10.1039/d0md00074d 10.7270/Q2P272RV 33479670 Matheson, CJ; Coxon, CR; Bayliss, R; Boxall, K; Carbain, B; Fry, AM; Hardcastle, IR; Harnor, SJ; Mas-Droux, C; Newell, DR; Richards, MW; Sivaprakasam, M; Turner, D; Griffin, RJ; Golding, BT; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235361&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137640457 384991235 CHEMBL4074015 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51368324 C#Cc1nc(Nc2ccccc2)nc2[nH]cnc12 InChI=1S/C13H9N5/c1-2-10-11-12(15-8-14-11)18-13(17-10)16-9-6-4-3-5-7-9/h1,3-8H,(H2,14,15,16,17,18) PRKFJWMFXNJCLC-UHFFFAOYSA-N 50235350 CHEMBL4094562 Serine/threonine-protein kinase PLK1 Homo sapiens 15000 ChEMBL 10.1039/d0md00074d 10.7270/Q2P272RV 33479670 Matheson, CJ; Coxon, CR; Bayliss, R; Boxall, K; Carbain, B; Fry, AM; Hardcastle, IR; Harnor, SJ; Mas-Droux, C; Newell, DR; Richards, MW; Sivaprakasam, M; Turner, D; Griffin, RJ; Golding, BT; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235350&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137653554 384991224 CHEMBL4094562 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357444 Fc1ccc2c(c1)c(=O)n(CC1CC1)c1n[nH]c(=S)n21 InChI=1S/C13H11FN4OS/c14-8-3-4-10-9(5-8)11(19)17(6-7-1-2-7)12-15-16-13(20)18(10)12/h3-5,7H,1-2,6H2,(H,16,20) JSRQZDANZDRJOA-UHFFFAOYSA-N 50548834 CHEMBL4786053 Serine/threonine-protein kinase PLK1 Homo sapiens 470 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548834&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667407 461679174 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357445 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 IYLBMSHZRRWSRM-FALOATQWSA-N 50426931 CHEMBL2323729 Serine/threonine-protein kinase PLK1 Homo sapiens 22000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42608451 164155806 CHEMBL2323729 ZINC95584623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357446 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 IYLBMSHZRRWSRM-FALOATQWSA-N 50426931 CHEMBL2323729 Serine/threonine-protein kinase PLK1 Homo sapiens 14740 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42608451 164155806 CHEMBL2323729 ZINC95584623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357447 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ccccc12 InChI=1S/C17H14N4OS/c22-15-13-8-4-5-9-14(13)21-16(18-19-17(21)23)20(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,23) VBEUIVPLCISBPO-UHFFFAOYSA-N 50548835 CHEMBL4761146 Serine/threonine-protein kinase PLK1 Homo sapiens 4380 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548835&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46507106 461679175 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357448 O=c1[nH]nc2n(CCc3ccccc3)c(=O)c3ccccc3n12 InChI=1S/C17H14N4O2/c22-15-13-8-4-5-9-14(13)21-16(18-19-17(21)23)20(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,23) KWEODWFOJBTABR-UHFFFAOYSA-N 50548836 CHEMBL4760499 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548836&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 22425028 461679176 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357449 Nc1nnc2n(CCc3ccccc3)c(=O)c3cc(F)ccc3n12 InChI=1S/C17H14FN5O/c18-12-6-7-14-13(10-12)15(24)22(17-21-20-16(19)23(14)17)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H2,19,20) KGTKDLFXVPRUKS-UHFFFAOYSA-N 50548837 CHEMBL4788810 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669147 461679177 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357450 Cc1nnc2n(CCc3ccccc3)c(=O)c3cc(F)ccc3n12 InChI=1S/C18H15FN4O/c1-12-20-21-18-22(10-9-13-5-3-2-4-6-13)17(24)15-11-14(19)7-8-16(15)23(12)18/h2-8,11H,9-10H2,1H3 LOHAFILBHRXMKM-UHFFFAOYSA-N 50548838 CHEMBL4748102 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650392 461679178 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357451 Fc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1nncn21 InChI=1S/C17H13FN4O/c18-13-6-7-15-14(10-13)16(23)21(17-20-19-11-22(15)17)9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2 PSUTUXIHUNZQGZ-UHFFFAOYSA-N 50548839 CHEMBL4797819 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548839&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674902 461679179 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357452 CSc1nnc2n(CCc3ccccc3)c(=O)c3ccccc3n12 InChI=1S/C18H16N4OS/c1-24-18-20-19-17-21(12-11-13-7-3-2-4-8-13)16(23)14-9-5-6-10-15(14)22(17)18/h2-10H,11-12H2,1H3 CVZBWMNEGHUSHE-UHFFFAOYSA-N 50548840 CHEMBL4764923 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548840&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162661923 461679180 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357453 CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C11H10N4OS/c1-2-14-9(16)7-5-3-4-6-8(7)15-10(14)12-13-11(15)17/h3-6H,2H2,1H3,(H,13,17) KRGHJDLASPDNFI-UHFFFAOYSA-N 50548841 CHEMBL4754533 Serine/threonine-protein kinase PLK1 Homo sapiens 1490 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548841&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7064020 461679181 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357454 CCCn1c2nnc(S)n2c2ccccc2c1=O InChI=1S/C12H12N4OS/c1-2-7-15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h3-6H,2,7H2,1H3,(H,14,18) VTEKNXCWZXDPEY-UHFFFAOYSA-N 50548842 CHEMBL1396239 Serine/threonine-protein kinase PLK1 Homo sapiens 1030 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548842&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2423905 461679182 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357455 Sc1nnc2n(CC=C)c(=O)c3ccccc3n12 InChI=1S/C12H10N4OS/c1-2-7-15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h2-6H,1,7H2,(H,14,18) HOAFKCJEEQOECV-UHFFFAOYSA-N 50548843 CHEMBL1478489 Serine/threonine-protein kinase PLK1 Homo sapiens 1310 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548843&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2363795 461679183 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357456 CCCCn1c2nnc(S)n2c2ccccc2c1=O InChI=1S/C13H14N4OS/c1-2-3-8-16-11(18)9-6-4-5-7-10(9)17-12(16)14-15-13(17)19/h4-7H,2-3,8H2,1H3,(H,15,19) NURBAHNZLYZFMA-UHFFFAOYSA-N 50548844 CHEMBL1310492 Serine/threonine-protein kinase PLK1 Homo sapiens 1030 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548844&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2120114 461679184 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357457 CCCCCn1c2nnc(S)n2c2ccccc2c1=O InChI=1S/C14H16N4OS/c1-2-3-6-9-17-12(19)10-7-4-5-8-11(10)18-13(17)15-16-14(18)20/h4-5,7-8H,2-3,6,9H2,1H3,(H,16,20) YOCBHSHCCGTRNO-UHFFFAOYSA-N 50548845 CHEMBL1412746 Serine/threonine-protein kinase PLK1 Homo sapiens 1970 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548845&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2081016 461679185 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357458 CC(C)CCn1c2nnc(S)n2c2ccccc2c1=O InChI=1S/C14H16N4OS/c1-9(2)7-8-17-12(19)10-5-3-4-6-11(10)18-13(17)15-16-14(18)20/h3-6,9H,7-8H2,1-2H3,(H,16,20) CDNKKHCCJLPULM-UHFFFAOYSA-N 50548846 CHEMBL1537130 Serine/threonine-protein kinase PLK1 Homo sapiens 1730 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548846&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2120341 461679186 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357459 CC(C)n1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H12N4OS/c1-7(2)15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h3-7H,1-2H3,(H,14,18) DLOSRXVROQPHNY-UHFFFAOYSA-N 50548847 CHEMBL4748147 Serine/threonine-protein kinase PLK1 Homo sapiens 1300 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548847&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649750 461679187 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357460 FC(F)(F)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H9F3N4OS/c13-12(14,15)5-6-18-9(20)7-3-1-2-4-8(7)19-10(18)16-17-11(19)21/h1-4H,5-6H2,(H,17,21) OEKJJYKFVXFNPQ-UHFFFAOYSA-N 50548848 CHEMBL4798714 Serine/threonine-protein kinase PLK1 Homo sapiens 1250 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548848&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162676007 461679188 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357461 COCCCn1c2nnc(S)n2c2ccccc2c1=O InChI=1S/C13H14N4O2S/c1-19-8-4-7-16-11(18)9-5-2-3-6-10(9)17-12(16)14-15-13(17)20/h2-3,5-6H,4,7-8H2,1H3,(H,15,20) FGOFGESTKFLRBZ-UHFFFAOYSA-N 50548849 CHEMBL1435590 Serine/threonine-protein kinase PLK1 Homo sapiens 1750 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548849&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2081017 461679189 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357462 CCOCCCn1c2nnc(S)n2c2ccccc2c1=O InChI=1S/C14H16N4O2S/c1-2-20-9-5-8-17-12(19)10-6-3-4-7-11(10)18-13(17)15-16-14(18)21/h3-4,6-7H,2,5,8-9H2,1H3,(H,16,21) IWTGZWFZSRRECN-UHFFFAOYSA-N 50548850 CHEMBL1606561 Serine/threonine-protein kinase PLK1 Homo sapiens 1680 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548850&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2110924 461679190 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357463 CCC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O 50548851 CHEMBL4757529 Serine/threonine-protein kinase PLK1 Homo sapiens 3230 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548851&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743362 461679191 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357464 CC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C15H17N5O2S/c1-9(2)16-12(21)7-8-19-13(22)10-5-3-4-6-11(10)20-14(19)17-18-15(20)23/h3-6,9H,7-8H2,1-2H3,(H,16,21)(H,18,23) YATBHHZNVXTYJO-UHFFFAOYSA-N 50548852 CHEMBL4795383 Serine/threonine-protein kinase PLK1 Homo sapiens 3900 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548852&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743374 461679192 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357465 CC(C)CNC(=O)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C16H19N5O2S/c1-10(2)9-17-13(22)7-8-20-14(23)11-5-3-4-6-12(11)21-15(20)18-19-16(21)24/h3-6,10H,7-9H2,1-2H3,(H,17,22)(H,19,24) USTNJZLAIQFDOY-UHFFFAOYSA-N 50548853 CHEMBL4760714 Serine/threonine-protein kinase PLK1 Homo sapiens 2920 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548853&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743424 461679193 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357466 Cc1cccc(c1C)-n1c2nnc(S)n2c2ccccc2c1=O InChI=1S/C17H14N4OS/c1-10-6-5-9-13(11(10)2)20-15(22)12-7-3-4-8-14(12)21-16(20)18-19-17(21)23/h3-9H,1-2H3,(H,19,23) BLZLSOAYWCNFDM-UHFFFAOYSA-N 50548854 CHEMBL1595610 Serine/threonine-protein kinase PLK1 Homo sapiens 1850 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548854&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7064036 461679194 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357467 Fc1ccc(Cn2c3n[nH]c(=S)n3c3ccccc3c2=O)cc1 InChI=1S/C16H11FN4OS/c17-11-7-5-10(6-8-11)9-20-14(22)12-3-1-2-4-13(12)21-15(20)18-19-16(21)23/h1-8H,9H2,(H,19,23) OIYNRKLWHMUQSO-UHFFFAOYSA-N 50548855 CHEMBL4781514 Serine/threonine-protein kinase PLK1 Homo sapiens 3540 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548855&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2384603 461679195 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357468 CCCn1c2nn(CN(C)C3CC3)c(=S)n2c2ccccc2c1=O InChI=1S/C17H21N5OS/c1-3-10-20-15(23)13-6-4-5-7-14(13)22-16(20)18-21(17(22)24)11-19(2)12-8-9-12/h4-7,12H,3,8-11H2,1-2H3 NJIIJHDNOJRNIC-UHFFFAOYSA-N 50548856 CHEMBL4745057 Serine/threonine-protein kinase PLK1 Homo sapiens 1630 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548856&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137977962 461679196 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357469 CCCN(C)Cn1nc2n(C)c(=O)c3ccccc3n2c1=S InChI=1S/C15H19N5OS/c1-4-9-17(2)10-19-15(22)20-12-8-6-5-7-11(12)13(21)18(3)14(20)16-19/h5-8H,4,9-10H2,1-3H3 ARVXSSVHBIIKPE-UHFFFAOYSA-N 50548857 CHEMBL4797816 Serine/threonine-protein kinase PLK1 Homo sapiens 1200 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548857&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137979186 461679197 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357470 CCCN(C)Cn1nc2n(CCC)c(=O)c3ccccc3n2c1=S InChI=1S/C17H23N5OS/c1-4-10-19(3)12-21-17(24)22-14-9-7-6-8-13(14)15(23)20(11-5-2)16(22)18-21/h6-9H,4-5,10-12H2,1-3H3 WIZPROBUTYPMHD-UHFFFAOYSA-N 50548858 CHEMBL4785390 Serine/threonine-protein kinase PLK1 Homo sapiens 1830 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548858&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137979187 461679198 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357471 CCCn1c2nn(CN(CC)CC3CC3)c(=S)n2c2ccccc2c1=O InChI=1S/C19H25N5OS/c1-3-11-22-17(25)15-7-5-6-8-16(15)24-18(22)20-23(19(24)26)13-21(4-2)12-14-9-10-14/h5-8,14H,3-4,9-13H2,1-2H3 CNBJMHHTGWDMBW-UHFFFAOYSA-N 50548859 CHEMBL4778236 Serine/threonine-protein kinase PLK1 Homo sapiens 1670 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548859&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644446 461679199 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357472 CCCn1c2nn(CC(=O)c3ccccc3)c(=S)n2c2ccccc2c1=O InChI=1S/C20H18N4O2S/c1-2-12-22-18(26)15-10-6-7-11-16(15)24-19(22)21-23(20(24)27)13-17(25)14-8-4-3-5-9-14/h3-11H,2,12-13H2,1H3 VEIFQCWXUBNKKM-UHFFFAOYSA-N 50548860 CHEMBL4777333 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548860&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643629 461679200 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357473 Fc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C17H13FN4OS/c18-12-6-7-14-13(10-12)15(23)21(16-19-20-17(24)22(14)16)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) PWVRMPWRONITRC-UHFFFAOYSA-N 50548861 CHEMBL4760240 Serine/threonine-protein kinase PLK1 Homo sapiens 12920 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548861&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657514 461679201 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357474 Brc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C17H13BrN4OS/c18-12-6-7-14-13(10-12)15(23)21(16-19-20-17(24)22(14)16)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) POJBEZPPFIPGTF-UHFFFAOYSA-N 50548862 CHEMBL4763203 Serine/threonine-protein kinase PLK1 Homo sapiens 14740 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548862&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162660378 461679202 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357475 Ic1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C17H13IN4OS/c18-12-6-7-14-13(10-12)15(23)21(16-19-20-17(24)22(14)16)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) BQMIJZVLKIKAQJ-UHFFFAOYSA-N 50548863 CHEMBL4740835 Serine/threonine-protein kinase PLK1 Homo sapiens 30710 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548863&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644682 461679203 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357476 Cc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C18H16N4OS/c1-12-7-8-15-14(11-12)16(23)21(17-19-20-18(24)22(15)17)10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,20,24) GNEWVHKRNDFJCE-UHFFFAOYSA-N 50548864 CHEMBL4781557 Serine/threonine-protein kinase PLK1 Homo sapiens 11290 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548864&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664240 461679204 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357477 CC(=O)Nc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C19H17N5O2S/c1-12(25)20-14-7-8-16-15(11-14)17(26)23(18-21-22-19(27)24(16)18)10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,20,25)(H,22,27) WXOJSKLCQUJIFR-UHFFFAOYSA-N 50548865 CHEMBL4790284 Serine/threonine-protein kinase PLK1 Homo sapiens 2190 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548865&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162670193 461679205 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357478 CN(C)c1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C19H19N5OS/c1-22(2)14-8-9-16-15(12-14)17(25)23(18-20-21-19(26)24(16)18)11-10-13-6-4-3-5-7-13/h3-9,12H,10-11H2,1-2H3,(H,21,26) DSIFZPYEFYGDGH-UHFFFAOYSA-N 50548866 CHEMBL4778039 Serine/threonine-protein kinase PLK1 Homo sapiens 2770 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548866&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644184 461679206 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357479 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ccc(cc12)N1CCOCC1 InChI=1S/C21H21N5O2S/c27-19-17-14-16(24-10-12-28-13-11-24)6-7-18(17)26-20(22-23-21(26)29)25(19)9-8-15-4-2-1-3-5-15/h1-7,14H,8-13H2,(H,23,29) NZDUPSXPEXBPQQ-UHFFFAOYSA-N 50548867 CHEMBL4794319 Serine/threonine-protein kinase PLK1 Homo sapiens 1540 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548867&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162673177 461679207 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363969 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C29H39N9O2/c1-5-23-27-35-34-18(2)37(27)24-17-30-29(33-26(24)38(23)21-8-6-7-9-21)32-22-11-10-19(16-25(22)40-4)28(39)31-20-12-14-36(3)15-13-20/h10-11,16-17,20-21,23H,5-9,12-15H2,1-4H3,(H,31,39)(H,30,32,33)/t23-/m1/s1 QWAOMERKQXGSJH-HSZRJFAPSA-N 50551270 CHEMBL4776770 Serine/threonine-protein kinase PLK1 Homo sapiens 724 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551270&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643679 461681610 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363970 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H43N9O2/c1-5-25-29-37-36-20(2)40(29)26-18-32-31(35-28(26)39(25)19-21-9-7-6-8-10-21)34-24-12-11-22(17-27(24)42-4)30(41)33-23-13-15-38(3)16-14-23/h11-12,17-18,21,23,25H,5-10,13-16,19H2,1-4H3,(H,33,41)(H,32,34,35)/t25-/m1/s1 QUMCIHKVKQYNPA-RUZDIDTESA-N 50551271 CHEMBL4747491 Serine/threonine-protein kinase PLK1 Homo sapiens 109 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551271&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775102 461681611 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363971 CC[C@H]1N(Cc2ccccc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H37N9O2/c1-5-25-29-37-36-20(2)40(29)26-18-32-31(35-28(26)39(25)19-21-9-7-6-8-10-21)34-24-12-11-22(17-27(24)42-4)30(41)33-23-13-15-38(3)16-14-23/h6-12,17-18,23,25H,5,13-16,19H2,1-4H3,(H,33,41)(H,32,34,35)/t25-/m1/s1 YQCCDKOFONLPFF-RUZDIDTESA-N 50551272 CHEMBL4758654 Serine/threonine-protein kinase PLK1 Homo sapiens 434 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551272&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162658347 461681612 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363972 CC[C@H]1N(Cc2ccc(F)cc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H36FN9O2/c1-5-25-29-38-37-19(2)41(29)26-17-33-31(36-28(26)40(25)18-20-6-9-22(32)10-7-20)35-24-11-8-21(16-27(24)43-4)30(42)34-23-12-14-39(3)15-13-23/h6-11,16-17,23,25H,5,12-15,18H2,1-4H3,(H,34,42)(H,33,35,36)/t25-/m1/s1 OXMBEXXWWXTOCD-RUZDIDTESA-N 50551273 CHEMBL4785799 Serine/threonine-protein kinase PLK1 Homo sapiens 341 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551273&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667383 461681613 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363973 CC[C@H]1N(Cc2ccc(Cl)cc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H36ClN9O2/c1-5-25-29-38-37-19(2)41(29)26-17-33-31(36-28(26)40(25)18-20-6-9-22(32)10-7-20)35-24-11-8-21(16-27(24)43-4)30(42)34-23-12-14-39(3)15-13-23/h6-11,16-17,23,25H,5,12-15,18H2,1-4H3,(H,34,42)(H,33,35,36)/t25-/m1/s1 GCPQQOBOYKBWPO-RUZDIDTESA-N 50551274 CHEMBL4779839 Serine/threonine-protein kinase PLK1 Homo sapiens 162 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551274&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662404 461681614 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363974 CC[C@H]1N(Cc2ccc(Br)cc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H36BrN9O2/c1-5-25-29-38-37-19(2)41(29)26-17-33-31(36-28(26)40(25)18-20-6-9-22(32)10-7-20)35-24-11-8-21(16-27(24)43-4)30(42)34-23-12-14-39(3)15-13-23/h6-11,16-17,23,25H,5,12-15,18H2,1-4H3,(H,34,42)(H,33,35,36)/t25-/m1/s1 DHMVFGZTRVZQFI-RUZDIDTESA-N 50551275 CHEMBL4759851 Serine/threonine-protein kinase PLK1 Homo sapiens 154 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551275&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162658623 461681615 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363975 CC[C@H]1N(Cc2ccc(cc2)C(C)(C)C)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C35H45N9O2/c1-8-28-32-41-40-22(2)44(32)29-20-36-34(39-31(29)43(28)21-23-9-12-25(13-10-23)35(3,4)5)38-27-14-11-24(19-30(27)46-7)33(45)37-26-15-17-42(6)18-16-26/h9-14,19-20,26,28H,8,15-18,21H2,1-7H3,(H,37,45)(H,36,38,39)/t28-/m1/s1 YZOJFEPZEVKWPV-MUUNZHRXSA-N 50551276 CHEMBL4759383 Serine/threonine-protein kinase PLK1 Homo sapiens 138 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551276&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162658946 461681616 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363976 CCOc1ccc(CN2[C@H](CC)c3nnc(C)n3-c3cnc(Nc4ccc(cc4OC)C(=O)NC4CCN(C)CC4)nc23)cc1 InChI=1S/C33H41N9O3/c1-6-27-31-39-38-21(3)42(31)28-19-34-33(37-30(28)41(27)20-22-8-11-25(12-9-22)45-7-2)36-26-13-10-23(18-29(26)44-5)32(43)35-24-14-16-40(4)17-15-24/h8-13,18-19,24,27H,6-7,14-17,20H2,1-5H3,(H,35,43)(H,34,36,37)/t27-/m1/s1 HNLPHJIQJRDKKX-HHHXNRCGSA-N 50551277 CHEMBL4794106 Serine/threonine-protein kinase PLK1 Homo sapiens 169 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551277&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162673540 461681617 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363977 CC[C@H]1N(Cc2cccc(c2)C(F)(F)F)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C32H36F3N9O2/c1-5-25-29-41-40-19(2)44(29)26-17-36-31(39-28(26)43(25)18-20-7-6-8-22(15-20)32(33,34)35)38-24-10-9-21(16-27(24)46-4)30(45)37-23-11-13-42(3)14-12-23/h6-10,15-17,23,25H,5,11-14,18H2,1-4H3,(H,37,45)(H,36,38,39)/t25-/m1/s1 OGBRMNPYWOVJQQ-RUZDIDTESA-N 50551278 CHEMBL4793358 Serine/threonine-protein kinase PLK1 Homo sapiens 150 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551278&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162673731 461681618 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363978 CC[C@H]1N(Cc2cccc(Cl)c2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H36ClN9O2/c1-5-25-29-38-37-19(2)41(29)26-17-33-31(36-28(26)40(25)18-20-7-6-8-22(32)15-20)35-24-10-9-21(16-27(24)43-4)30(42)34-23-11-13-39(3)14-12-23/h6-10,15-17,23,25H,5,11-14,18H2,1-4H3,(H,34,42)(H,33,35,36)/t25-/m1/s1 YYEWDYMBVPPZDJ-RUZDIDTESA-N 50551279 CHEMBL4751651 Serine/threonine-protein kinase PLK1 Homo sapiens 172 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551279&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652601 461681619 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363979 CC[C@H]1N(Cc2cccc(Br)c2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H36BrN9O2/c1-5-25-29-38-37-19(2)41(29)26-17-33-31(36-28(26)40(25)18-20-7-6-8-22(32)15-20)35-24-10-9-21(16-27(24)43-4)30(42)34-23-11-13-39(3)14-12-23/h6-10,15-17,23,25H,5,11-14,18H2,1-4H3,(H,34,42)(H,33,35,36)/t25-/m1/s1 MMGBSWRVNVBEIM-RUZDIDTESA-N 50551280 CHEMBL4755685 Serine/threonine-protein kinase PLK1 Homo sapiens 108 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551280&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655193 461681620 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363980 CC[C@H]1N(Cc2ccccn2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C30H36N10O2/c1-5-24-28-37-36-19(2)40(28)25-17-32-30(35-27(25)39(24)18-22-8-6-7-13-31-22)34-23-10-9-20(16-26(23)42-4)29(41)33-21-11-14-38(3)15-12-21/h6-10,13,16-17,21,24H,5,11-12,14-15,18H2,1-4H3,(H,33,41)(H,32,34,35)/t24-/m1/s1 VUPMTAZCAWDMDG-XMMPIXPASA-N 50551281 CHEMBL4786547 Serine/threonine-protein kinase PLK1 Homo sapiens 3568 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551281&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667903 461681621 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363981 CC[C@H]1N(Cc2ccco2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C29H35N9O3/c1-5-23-27-35-34-18(2)38(27)24-16-30-29(33-26(24)37(23)17-21-7-6-14-41-21)32-22-9-8-19(15-25(22)40-4)28(39)31-20-10-12-36(3)13-11-20/h6-9,14-16,20,23H,5,10-13,17H2,1-4H3,(H,31,39)(H,30,32,33)/t23-/m1/s1 DVMCRBPTCKGCAX-HSZRJFAPSA-N 50551282 CHEMBL4751396 Serine/threonine-protein kinase PLK1 Homo sapiens 505 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551282&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650972 461681622 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363982 CC[C@H]1N(Cc2ccoc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C29H35N9O3/c1-5-23-27-35-34-18(2)38(27)24-15-30-29(33-26(24)37(23)16-19-10-13-41-17-19)32-22-7-6-20(14-25(22)40-4)28(39)31-21-8-11-36(3)12-9-21/h6-7,10,13-15,17,21,23H,5,8-9,11-12,16H2,1-4H3,(H,31,39)(H,30,32,33)/t23-/m1/s1 UNVPHVSVVHLLKD-HSZRJFAPSA-N 50551283 CHEMBL4777694 Serine/threonine-protein kinase PLK1 Homo sapiens 426 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551283&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644200 461681623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363983 CC[C@H]1N(Cc2cccs2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C29H35N9O2S/c1-5-23-27-35-34-18(2)38(27)24-16-30-29(33-26(24)37(23)17-21-7-6-14-41-21)32-22-9-8-19(15-25(22)40-4)28(39)31-20-10-12-36(3)13-11-20/h6-9,14-16,20,23H,5,10-13,17H2,1-4H3,(H,31,39)(H,30,32,33)/t23-/m1/s1 FRVZZHQYKGFUEH-HSZRJFAPSA-N 50551284 CHEMBL4754471 Serine/threonine-protein kinase PLK1 Homo sapiens 71 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551284&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655000 461681624 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363984 CC[C@H]1N(Cc2ccsc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C29H35N9O2S/c1-5-23-27-35-34-18(2)38(27)24-15-30-29(33-26(24)37(23)16-19-10-13-41-17-19)32-22-7-6-20(14-25(22)40-4)28(39)31-21-8-11-36(3)12-9-21/h6-7,10,13-15,17,21,23H,5,8-9,11-12,16H2,1-4H3,(H,31,39)(H,30,32,33)/t23-/m1/s1 GEGMKHTYQVNYFV-HSZRJFAPSA-N 50551285 CHEMBL4755667 Serine/threonine-protein kinase PLK1 Homo sapiens 266 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551285&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655127 461681625 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363985 CC[C@H]1N(Cc2ccc(F)cc2)c2nc(Nc3ccccc3OC)ncc2-n2c(C)nnc12 InChI=1S/C24H24FN7O/c1-4-19-23-30-29-15(2)32(23)20-13-26-24(27-18-7-5-6-8-21(18)33-3)28-22(20)31(19)14-16-9-11-17(25)12-10-16/h5-13,19H,4,14H2,1-3H3,(H,26,27,28)/t19-/m1/s1 XOZJRQDITIJPCH-LJQANCHMSA-N 50551286 CHEMBL4793356 Serine/threonine-protein kinase PLK1 Homo sapiens 914 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551286&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775105 461681626 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363986 CC[C@H]1N(Cc2cccc(c2)C(F)(F)F)c2nc(Nc3ccccc3OC)ncc2-n2c(C)nnc12 InChI=1S/C25H24F3N7O/c1-4-19-23-33-32-15(2)35(23)20-13-29-24(30-18-10-5-6-11-21(18)36-3)31-22(20)34(19)14-16-8-7-9-17(12-16)25(26,27)28/h5-13,19H,4,14H2,1-3H3,(H,29,30,31)/t19-/m1/s1 CZIPRAPZEMYEBH-LJQANCHMSA-N 50551287 CHEMBL4757681 Serine/threonine-protein kinase PLK1 Homo sapiens 975 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551287&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775111 461681627 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363987 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NN3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C28H38N10O2/c1-5-22-26-33-32-18(2)37(26)23-17-29-28(31-25(23)38(22)20-8-6-7-9-20)30-21-11-10-19(16-24(21)40-4)27(39)34-36-14-12-35(3)13-15-36/h10-11,16-17,20,22H,5-9,12-15H2,1-4H3,(H,34,39)(H,29,30,31)/t22-/m1/s1 IGNHIECBXXHFPK-JOCHJYFZSA-N 50551288 CHEMBL4796952 Serine/threonine-protein kinase PLK1 Homo sapiens 516 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551288&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675218 461681628 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363988 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NN3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C30H42N10O2/c1-5-24-28-35-34-20(2)40(28)25-18-31-30(33-27(25)39(24)19-21-9-7-6-8-10-21)32-23-12-11-22(17-26(23)42-4)29(41)36-38-15-13-37(3)14-16-38/h11-12,17-18,21,24H,5-10,13-16,19H2,1-4H3,(H,36,41)(H,31,32,33)/t24-/m1/s1 QYUSWNWUSZFQJV-XMMPIXPASA-N 50551289 CHEMBL4749890 Serine/threonine-protein kinase PLK1 Homo sapiens 126 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551289&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652058 461681629 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363989 CC[C@H]1N(Cc2ccccc2)c2nc(Nc3ccc(cc3OC)C(=O)NN3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C30H36N10O2/c1-5-24-28-35-34-20(2)40(28)25-18-31-30(33-27(25)39(24)19-21-9-7-6-8-10-21)32-23-12-11-22(17-26(23)42-4)29(41)36-38-15-13-37(3)14-16-38/h6-12,17-18,24H,5,13-16,19H2,1-4H3,(H,36,41)(H,31,32,33)/t24-/m1/s1 INBHXNZJARFRRF-XMMPIXPASA-N 50551290 CHEMBL4747773 Serine/threonine-protein kinase PLK1 Homo sapiens 352 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551290&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649453 461681630 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363990 CC[C@H]1N(Cc2ccc(F)cc2)c2nc(Nc3ccc(cc3OC)C(=O)NN3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C30H35FN10O2/c1-5-24-28-36-35-19(2)41(28)25-17-32-30(34-27(25)40(24)18-20-6-9-22(31)10-7-20)33-23-11-8-21(16-26(23)43-4)29(42)37-39-14-12-38(3)13-15-39/h6-11,16-17,24H,5,12-15,18H2,1-4H3,(H,37,42)(H,32,33,34)/t24-/m1/s1 FRVAEEMWIWELKQ-XMMPIXPASA-N 50551291 CHEMBL4794713 Serine/threonine-protein kinase PLK1 Homo sapiens 284 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551291&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162673427 461681631 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363991 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C30H41N9O2/c1-4-24-28-36-32-19-39(28)25-17-31-30(35-27(25)38(24)18-20-8-6-5-7-9-20)34-23-11-10-21(16-26(23)41-3)29(40)33-22-12-14-37(2)15-13-22/h10-11,16-17,19-20,22,24H,4-9,12-15,18H2,1-3H3,(H,33,40)(H,31,34,35)/t24-/m1/s1 IUQCUPONKHCDCN-XMMPIXPASA-N 50551292 CHEMBL4758859 Serine/threonine-protein kinase PLK1 Homo sapiens 2214 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551292&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775104 461681632 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363992 CC[C@H]1N(Cc2ccc(F)cc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C30H34FN9O2/c1-4-24-28-37-33-18-40(28)25-16-32-30(36-27(25)39(24)17-19-5-8-21(31)9-6-19)35-23-10-7-20(15-26(23)42-3)29(41)34-22-11-13-38(2)14-12-22/h5-10,15-16,18,22,24H,4,11-14,17H2,1-3H3,(H,34,41)(H,32,35,36)/t24-/m1/s1 SQPXDRNKYSMQQD-XMMPIXPASA-N 50551293 CHEMBL4749403 Serine/threonine-protein kinase PLK1 Homo sapiens 3693 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551293&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775110 461681633 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363993 CC[C@H]1N(Cc2ccc(Cl)cc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C30H34ClN9O2/c1-4-24-28-37-33-18-40(28)25-16-32-30(36-27(25)39(24)17-19-5-8-21(31)9-6-19)35-23-10-7-20(15-26(23)42-3)29(41)34-22-11-13-38(2)14-12-22/h5-10,15-16,18,22,24H,4,11-14,17H2,1-3H3,(H,34,41)(H,32,35,36)/t24-/m1/s1 XCKIPHSCDLNDDW-XMMPIXPASA-N 50551294 CHEMBL4795513 Serine/threonine-protein kinase PLK1 Homo sapiens 2766 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551294&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775098 461681634 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363994 CC[C@H]1N(Cc2ccc(cc2)C(C)(C)C)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C34H43N9O2/c1-7-27-31-40-36-21-43(31)28-19-35-33(39-30(28)42(27)20-22-8-11-24(12-9-22)34(2,3)4)38-26-13-10-23(18-29(26)45-6)32(44)37-25-14-16-41(5)17-15-25/h8-13,18-19,21,25,27H,7,14-17,20H2,1-6H3,(H,37,44)(H,35,38,39)/t27-/m1/s1 CKXMKEHIZGVZKY-HHHXNRCGSA-N 50551295 CHEMBL4796127 Serine/threonine-protein kinase PLK1 Homo sapiens 4870 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551295&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674142 461681635 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363995 CCOc1ccc(CN2[C@H](CC)c3nncn3-c3cnc(Nc4ccc(cc4OC)C(=O)NC4CCN(C)CC4)nc23)cc1 InChI=1S/C32H39N9O3/c1-5-26-30-38-34-20-41(30)27-18-33-32(37-29(27)40(26)19-21-7-10-24(11-8-21)44-6-2)36-25-12-9-22(17-28(25)43-4)31(42)35-23-13-15-39(3)16-14-23/h7-12,17-18,20,23,26H,5-6,13-16,19H2,1-4H3,(H,35,42)(H,33,36,37)/t26-/m1/s1 NFLBKSBPFWEPMG-AREMUKBSSA-N 50551296 CHEMBL4795074 Serine/threonine-protein kinase PLK1 Homo sapiens 2915 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551296&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775100 461681636 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363996 CC[C@H]1N(Cc2ccc(OC)c(OC)c2OC)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C33H41N9O5/c1-7-24-31-39-35-19-42(31)25-17-34-33(38-30(25)41(24)18-21-9-11-26(44-3)29(47-6)28(21)46-5)37-23-10-8-20(16-27(23)45-4)32(43)36-22-12-14-40(2)15-13-22/h8-11,16-17,19,22,24H,7,12-15,18H2,1-6H3,(H,36,43)(H,34,37,38)/t24-/m1/s1 BWUFJHRAUCYZNR-XMMPIXPASA-N 50551297 CHEMBL4757805 Serine/threonine-protein kinase PLK1 Homo sapiens 4400 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551297&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775099 461681637 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363997 CC[C@H]1N(Cc2cccc(c2)C(F)(F)F)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C31H34F3N9O2/c1-4-24-28-40-36-18-43(28)25-16-35-30(39-27(25)42(24)17-19-6-5-7-21(14-19)31(32,33)34)38-23-9-8-20(15-26(23)45-3)29(44)37-22-10-12-41(2)13-11-22/h5-9,14-16,18,22,24H,4,10-13,17H2,1-3H3,(H,37,44)(H,35,38,39)/t24-/m1/s1 IFPOCFWAOVVNBY-XMMPIXPASA-N 50551298 CHEMBL4740899 Serine/threonine-protein kinase PLK1 Homo sapiens 7504 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551298&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775103 461681638 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363998 CC[C@H]1N(Cc2cccc(Br)c2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C30H34BrN9O2/c1-4-24-28-37-33-18-40(28)25-16-32-30(36-27(25)39(24)17-19-6-5-7-21(31)14-19)35-23-9-8-20(15-26(23)42-3)29(41)34-22-10-12-38(2)13-11-22/h5-9,14-16,18,22,24H,4,10-13,17H2,1-3H3,(H,34,41)(H,32,35,36)/t24-/m1/s1 FBMMHPFJCKVOQE-XMMPIXPASA-N 50551299 CHEMBL4749073 Serine/threonine-protein kinase PLK1 Homo sapiens 2764 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551299&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775107 461681639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51363999 CC[C@H]1N(Cc2ccco2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C28H33N9O3/c1-4-22-26-34-30-17-37(26)23-15-29-28(33-25(23)36(22)16-20-6-5-13-40-20)32-21-8-7-18(14-24(21)39-3)27(38)31-19-9-11-35(2)12-10-19/h5-8,13-15,17,19,22H,4,9-12,16H2,1-3H3,(H,31,38)(H,29,32,33)/t22-/m1/s1 YLWCWWXFUDMWQL-JOCHJYFZSA-N 50551300 CHEMBL4756075 Serine/threonine-protein kinase PLK1 Homo sapiens 6375 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551300&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775109 461681640 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364000 CC[C@H]1N(Cc2ccoc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C28H33N9O3/c1-4-22-26-34-30-17-37(26)23-14-29-28(33-25(23)36(22)15-18-9-12-40-16-18)32-21-6-5-19(13-24(21)39-3)27(38)31-20-7-10-35(2)11-8-20/h5-6,9,12-14,16-17,20,22H,4,7-8,10-11,15H2,1-3H3,(H,31,38)(H,29,32,33)/t22-/m1/s1 KZECJTRTXIDCQE-JOCHJYFZSA-N 50551301 CHEMBL4791394 Serine/threonine-protein kinase PLK1 Homo sapiens 4897 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551301&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775101 461681641 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364001 CC[C@H]1N(Cc2cccs2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C28H33N9O2S/c1-4-22-26-34-30-17-37(26)23-15-29-28(33-25(23)36(22)16-20-6-5-13-40-20)32-21-8-7-18(14-24(21)39-3)27(38)31-19-9-11-35(2)12-10-19/h5-8,13-15,17,19,22H,4,9-12,16H2,1-3H3,(H,31,38)(H,29,32,33)/t22-/m1/s1 QAXLVTMCZJASSF-JOCHJYFZSA-N 50551302 CHEMBL4791753 Serine/threonine-protein kinase PLK1 Homo sapiens 1386 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551302&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775108 461681642 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364002 CC[C@H]1N(Cc2ccsc2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C28H33N9O2S/c1-4-22-26-34-30-17-37(26)23-14-29-28(33-25(23)36(22)15-18-9-12-40-16-18)32-21-6-5-19(13-24(21)39-3)27(38)31-20-7-10-35(2)11-8-20/h5-6,9,12-14,16-17,20,22H,4,7-8,10-11,15H2,1-3H3,(H,31,38)(H,29,32,33)/t22-/m1/s1 ZHAWZXKTPNATHF-JOCHJYFZSA-N 50551303 CHEMBL4755706 Serine/threonine-protein kinase PLK1 Homo sapiens 2304 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551303&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775106 461681643 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364003 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccccc3OC)ncc2-n2cnnc12 InChI=1S/C21H25N7O/c1-3-16-20-26-23-13-27(20)17-12-22-21(24-15-10-6-7-11-18(15)29-2)25-19(17)28(16)14-8-4-5-9-14/h6-7,10-14,16H,3-5,8-9H2,1-2H3,(H,22,24,25)/t16-/m1/s1 AWEYXSHVNVPHJL-MRXNPFEDSA-N 50551304 CHEMBL4796137 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551304&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674256 461681644 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364004 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NN3CCN(C)CC3)ncc2-n2cnnc12 InChI=1S/C29H40N10O2/c1-4-23-27-34-31-19-39(27)24-17-30-29(33-26(24)38(23)18-20-8-6-5-7-9-20)32-22-11-10-21(16-25(22)41-3)28(40)35-37-14-12-36(2)13-15-37/h10-11,16-17,19-20,23H,4-9,12-15,18H2,1-3H3,(H,35,40)(H,30,32,33)/t23-/m1/s1 AINOPURVZRXYJI-HSZRJFAPSA-N 50551305 CHEMBL4750219 Serine/threonine-protein kinase PLK1 Homo sapiens 2085 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551305&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162651458 461681645 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364005 CCOc1ccc(CN2[C@H](CC)c3nncn3-c3cnc(Nc4ccc(cc4OC)C(=O)NN4CCN(C)CC4)nc23)cc1 InChI=1S/C31H38N10O3/c1-5-25-29-36-33-20-41(29)26-18-32-31(35-28(26)40(25)19-21-7-10-23(11-8-21)44-6-2)34-24-12-9-22(17-27(24)43-4)30(42)37-39-15-13-38(3)14-16-39/h7-12,17-18,20,25H,5-6,13-16,19H2,1-4H3,(H,37,42)(H,32,34,35)/t25-/m1/s1 MERYXOYVDBUNKA-RUZDIDTESA-N 50551306 CHEMBL4796986 Serine/threonine-protein kinase PLK1 Homo sapiens 2575 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551306&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675505 461681646 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51364006 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 106 ChEMBL 10.1016/j.ejmech.2020.112152 10.7270/Q20V8HF9 32088495 Wang, NY; Xu, Y; Xiao, KJ; Zuo, WQ; Zhu, YX; Hu, R; Wang, WL; Shi, YJ; Yu, LT; Liu, ZH Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357480 Fc1ccc2c(c1)n1c(n[nH]c1=S)n(CCc1ccccc1)c2=O InChI=1S/C17H13FN4OS/c18-12-6-7-13-14(10-12)22-16(19-20-17(22)24)21(15(13)23)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) ARXNISBPPXAEET-UHFFFAOYSA-N 50548868 CHEMBL4790198 Serine/threonine-protein kinase PLK1 Homo sapiens 8290 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548868&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668950 461679208 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357481 Fc1cccc2c1n1c(n[nH]c1=S)n(CCc1ccccc1)c2=O InChI=1S/C17H13FN4OS/c18-13-8-4-7-12-14(13)22-16(19-20-17(22)24)21(15(12)23)10-9-11-5-2-1-3-6-11/h1-8H,9-10H2,(H,20,24) GXFFIIRYUDXYSJ-UHFFFAOYSA-N 50548869 CHEMBL4753929 Serine/threonine-protein kinase PLK1 Homo sapiens 2580 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548869&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654287 461679209 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357482 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2cccnc12 InChI=1S/C16H13N5OS/c22-14-13-12(7-4-9-17-13)21-15(18-19-16(21)23)20(14)10-8-11-5-2-1-3-6-11/h1-7,9H,8,10H2,(H,19,23) UNXSVXQBBSODJB-UHFFFAOYSA-N 50548870 CHEMBL4748954 Serine/threonine-protein kinase PLK1 Homo sapiens 6160 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548870&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649280 461679210 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357483 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2cnccc12 InChI=1S/C16H13N5OS/c22-14-12-6-8-17-10-13(12)21-15(18-19-16(21)23)20(14)9-7-11-4-2-1-3-5-11/h1-6,8,10H,7,9H2,(H,19,23) CRBAQEJPOKUWAO-UHFFFAOYSA-N 50548871 CHEMBL4761255 Serine/threonine-protein kinase PLK1 Homo sapiens 27780 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548871&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659833 461679211 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357484 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ncccc12 InChI=1S/C16H13N5OS/c22-14-12-7-4-9-17-13(12)21-15(18-19-16(21)23)20(14)10-8-11-5-2-1-3-6-11/h1-7,9H,8,10H2,(H,19,23) YQVFVYPOJDIQNU-UHFFFAOYSA-N 50548872 CHEMBL4785169 Serine/threonine-protein kinase PLK1 Homo sapiens 7550 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548872&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162666285 461679212 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357485 Fc1ccc2c(c1)c(=O)n(Cc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C16H11FN4OS/c17-11-6-7-13-12(8-11)14(22)20(9-10-4-2-1-3-5-10)15-18-19-16(23)21(13)15/h1-8H,9H2,(H,19,23) VIGACJGWPVPHBB-UHFFFAOYSA-N 50548873 CHEMBL4742355 Serine/threonine-protein kinase PLK1 Homo sapiens 6420 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548873&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646713 461679213 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357486 Fc1ccc2c(c1)c(=O)n(CCCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C18H15FN4OS/c19-13-8-9-15-14(11-13)16(24)22(17-20-21-18(25)23(15)17)10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11H,4,7,10H2,(H,21,25) YVYISAUWEDGFCH-UHFFFAOYSA-N 50548874 CHEMBL4782336 Serine/threonine-protein kinase PLK1 Homo sapiens 6630 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548874&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664618 461679214 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357487 CCCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C12H11ClN4OS/c1-2-5-16-10(18)8-6-7(13)3-4-9(8)17-11(16)14-15-12(17)19/h3-4,6H,2,5H2,1H3,(H,15,19) HXJVZTMGWRDKKD-UHFFFAOYSA-N 50548875 CHEMBL4784212 Serine/threonine-protein kinase PLK1 Homo sapiens 1770 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548875&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743387 461679215 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357488 FC(F)(F)CCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C12H8ClF3N4OS/c13-6-1-2-8-7(5-6)9(21)19(4-3-12(14,15)16)10-17-18-11(22)20(8)10/h1-2,5H,3-4H2,(H,18,22) FRGSZPKQZLHMCL-UHFFFAOYSA-N 50548876 CHEMBL4758856 Serine/threonine-protein kinase PLK1 Homo sapiens 2140 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548876&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657854 461679216 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357489 CC(C)OCCCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C15H17ClN4O2S/c1-9(2)22-7-3-6-19-13(21)11-8-10(16)4-5-12(11)20-14(19)17-18-15(20)23/h4-5,8-9H,3,6-7H2,1-2H3,(H,18,23) XQVTWTZOKDBSJM-UHFFFAOYSA-N 50548877 CHEMBL4756416 Serine/threonine-protein kinase PLK1 Homo sapiens 1620 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548877&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743388 461679217 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357490 CC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C15H16ClN5O2S/c1-8(2)17-12(22)5-6-20-13(23)10-7-9(16)3-4-11(10)21-14(20)18-19-15(21)24/h3-4,7-8H,5-6H2,1-2H3,(H,17,22)(H,19,24) XCCDPANCNAOECG-UHFFFAOYSA-N 50548878 CHEMBL4746990 Serine/threonine-protein kinase PLK1 Homo sapiens 1490 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548878&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743373 461679218 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357491 CC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccc(C)cc2c1=O InChI=1S/C16H19N5O2S/c1-9(2)17-13(22)6-7-20-14(23)11-8-10(3)4-5-12(11)21-15(20)18-19-16(21)24/h4-5,8-9H,6-7H2,1-3H3,(H,17,22)(H,19,24) OPXAZSSKPXNTRH-UHFFFAOYSA-N 50548879 CHEMBL4740867 Serine/threonine-protein kinase PLK1 Homo sapiens 2010 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548879&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743425 461679219 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357492 CCCn1c2n[nH]c(=S)n2c2cc(ccc2c1=O)C(=O)NC(C)C InChI=1S/C16H19N5O2S/c1-4-7-20-14(23)11-6-5-10(13(22)17-9(2)3)8-12(11)21-15(20)18-19-16(21)24/h5-6,8-9H,4,7H2,1-3H3,(H,17,22)(H,19,24) ZKOYITQVZRJHGZ-UHFFFAOYSA-N 50548880 CHEMBL4754153 Serine/threonine-protein kinase PLK1 Homo sapiens 3010 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548880&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743123 461679220 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357493 CC(C)CCn1c2n[nH]c(=S)n2c2cc(ccc2c1=O)C(=O)NC1CCCC1 InChI=1S/C20H25N5O2S/c1-12(2)9-10-24-18(27)15-8-7-13(17(26)21-14-5-3-4-6-14)11-16(15)25-19(24)22-23-20(25)28/h7-8,11-12,14H,3-6,9-10H2,1-2H3,(H,21,26)(H,23,28) HNGRKHKTYDCKHH-UHFFFAOYSA-N 50548881 CHEMBL4551650 Serine/threonine-protein kinase PLK1 Homo sapiens 11110 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548881&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46507130 461679221 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357494 Cn1c2n[nH]c(=S)n2c2cc(ccc2c1=O)C(=O)NC1CCCC1 InChI=1S/C16H17N5O2S/c1-20-14(23)11-7-6-9(13(22)17-10-4-2-3-5-10)8-12(11)21-15(20)18-19-16(21)24/h6-8,10H,2-5H2,1H3,(H,17,22)(H,19,24) RHGIGRMBINVXCT-UHFFFAOYSA-N 50548882 CHEMBL4778744 Serine/threonine-protein kinase PLK1 Homo sapiens 2750 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548882&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743088 461679222 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357495 CNC(=S)N1CN(CCc2ccccc2)C(=O)c2cc(F)ccc12 InChI=1S/C18H18FN3OS/c1-20-18(24)22-12-21(10-9-13-5-3-2-4-6-13)17(23)15-11-14(19)7-8-16(15)22/h2-8,11H,9-10,12H2,1H3,(H,20,24) WVLYQUZMHQKAFJ-UHFFFAOYSA-N 50548883 CHEMBL4761200 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548883&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659178 461679223 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357496 CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C11H9FN4OS/c1-2-15-9(17)7-5-6(12)3-4-8(7)16-10(15)13-14-11(16)18/h3-5H,2H2,1H3,(H,14,18) ZFZIUCSCTPUEMS-UHFFFAOYSA-N 50548884 CHEMBL4751837 Serine/threonine-protein kinase PLK1 Homo sapiens 1980 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548884&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652827 461679224 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357497 CCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H11FN4OS/c1-2-5-16-10(18)8-6-7(13)3-4-9(8)17-11(16)14-15-12(17)19/h3-4,6H,2,5H2,1H3,(H,15,19) ICNXHKBTCLSKNU-UHFFFAOYSA-N 50548885 CHEMBL4793697 Serine/threonine-protein kinase PLK1 Homo sapiens 1160 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548885&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743203 461679225 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357498 Fc1ccc2c(c1)c(=O)n(CCC(F)(F)F)c1n[nH]c(=S)n21 InChI=1S/C12H8F4N4OS/c13-6-1-2-8-7(5-6)9(21)19(4-3-12(14,15)16)10-17-18-11(22)20(8)10/h1-2,5H,3-4H2,(H,18,22) KQLVCCQCJZYYBX-UHFFFAOYSA-N 50548886 CHEMBL4755597 Serine/threonine-protein kinase PLK1 Homo sapiens 750 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548886&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655125 461679226 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357499 OCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H11FN4O2S/c13-7-2-3-9-8(6-7)10(19)16(4-1-5-18)11-14-15-12(20)17(9)11/h2-3,6,18H,1,4-5H2,(H,15,20) BKPWWWIXOIQUCN-UHFFFAOYSA-N 50548887 CHEMBL4745372 Serine/threonine-protein kinase PLK1 Homo sapiens 1440 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548887&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162647557 461679227 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357500 NCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C11H10FN5OS/c12-6-1-2-8-7(5-6)9(18)16(4-3-13)10-14-15-11(19)17(8)10/h1-2,5H,3-4,13H2,(H,15,19) GGOPLEZJCSAANI-UHFFFAOYSA-N 50548888 CHEMBL4751497 Serine/threonine-protein kinase PLK1 Homo sapiens 4330 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548888&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652031 461679228 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357501 NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H12FN5OS/c13-7-2-3-9-8(6-7)10(19)17(5-1-4-14)11-15-16-12(20)18(9)11/h2-3,6H,1,4-5,14H2,(H,16,20) NHKMVUTYRNAGOV-UHFFFAOYSA-N 50548889 CHEMBL4754906 Serine/threonine-protein kinase PLK1 Homo sapiens 2260 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548889&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654616 461679229 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357502 NCCCn1c2n[nH]c(=S)n2c2c(F)cccc2c1=O InChI=1S/C12H12FN5OS/c13-8-4-1-3-7-9(8)18-11(15-16-12(18)20)17(10(7)19)6-2-5-14/h1,3-4H,2,5-6,14H2,(H,16,20) KJVKMIZOPMZUQR-UHFFFAOYSA-N 50548890 CHEMBL4755386 Serine/threonine-protein kinase PLK1 Homo sapiens 5070 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548890&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655710 461679230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357503 CN(C)CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C13H14FN5OS/c1-17(2)5-6-18-11(20)9-7-8(14)3-4-10(9)19-12(18)15-16-13(19)21/h3-4,7H,5-6H2,1-2H3,(H,16,21) ITFZJFPHTIDQPE-UHFFFAOYSA-N 50548891 CHEMBL4747805 Serine/threonine-protein kinase PLK1 Homo sapiens 2450 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548891&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649964 461679231 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357504 CC(CN(C)C)n1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548892 CHEMBL4789908 Serine/threonine-protein kinase PLK1 Homo sapiens 6120 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548892&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668802 461679232 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357505 CC(=O)NCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C13H12FN5O2S/c1-7(20)15-4-5-18-11(21)9-6-8(14)2-3-10(9)19-12(18)16-17-13(19)22/h2-3,6H,4-5H2,1H3,(H,15,20)(H,17,22) FFZWMMMZSQJIJZ-UHFFFAOYSA-N 50548893 CHEMBL4781312 Serine/threonine-protein kinase PLK1 Homo sapiens 2480 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548893&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663909 461679233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357506 CC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C14H14FN5O2S/c1-8(21)16-5-2-6-19-12(22)10-7-9(15)3-4-11(10)20-13(19)17-18-14(20)23/h3-4,7H,2,5-6H2,1H3,(H,16,21)(H,18,23) FLXWQNVFPVCGCV-UHFFFAOYSA-N 50548894 CHEMBL4764140 Serine/threonine-protein kinase PLK1 Homo sapiens 2480 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548894&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662104 461679234 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357507 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)c1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C19H16FN5O2S/c20-13-7-8-15-14(11-13)17(27)24(18-22-23-19(28)25(15)18)10-4-9-21-16(26)12-5-2-1-3-6-12/h1-3,5-8,11H,4,9-10H2,(H,21,26)(H,23,28) PCCMTSCTMOZUIS-UHFFFAOYSA-N 50548895 CHEMBL4741656 Serine/threonine-protein kinase PLK1 Homo sapiens 1600 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548895&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646105 461679235 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357508 CS(=O)(=O)NCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H12FN5O3S2/c1-23(20,21)14-4-5-17-10(19)8-6-7(13)2-3-9(8)18-11(17)15-16-12(18)22/h2-3,6,14H,4-5H2,1H3,(H,16,22) XJJUWPYFFRPMAK-UHFFFAOYSA-N 50548896 CHEMBL4795189 Serine/threonine-protein kinase PLK1 Homo sapiens 2770 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548896&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162672902 461679236 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357509 CS(=O)(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C13H14FN5O3S2/c1-24(21,22)15-5-2-6-18-11(20)9-7-8(14)3-4-10(9)19-12(18)16-17-13(19)23/h3-4,7,15H,2,5-6H2,1H3,(H,17,23) RGJQYWGBXSGTJP-UHFFFAOYSA-N 50548897 CHEMBL4744283 Serine/threonine-protein kinase PLK1 Homo sapiens 1870 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548897&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162645881 461679237 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357510 OP(O)(=O)CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C11H10FN4O4PS/c12-6-1-2-8-7(5-6)9(17)15(3-4-21(18,19)20)10-13-14-11(22)16(8)10/h1-2,5H,3-4H2,(H,14,22)(H2,18,19,20) KTUNLJXBRLDWKB-UHFFFAOYSA-N 50548898 CHEMBL4755932 Serine/threonine-protein kinase PLK1 Homo sapiens 21700 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548898&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655609 461679238 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357511 CCOP(=O)(CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O)OCC InChI=1S/C15H18FN4O4PS/c1-3-23-25(22,24-4-2)8-7-19-13(21)11-9-10(16)5-6-12(11)20-14(19)17-18-15(20)26/h5-6,9H,3-4,7-8H2,1-2H3,(H,18,26) MBBHMDUYGKSPSI-UHFFFAOYSA-N 50548899 CHEMBL4752841 Serine/threonine-protein kinase PLK1 Homo sapiens 13890 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548899&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652487 461679239 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357512 Fc1ccc2c(c1)c(=O)n(CC1CC1)c1n[nH]c(=S)n21 InChI=1S/C13H11FN4OS/c14-8-3-4-10-9(5-8)11(19)17(6-7-1-2-7)12-15-16-13(20)18(10)12/h3-5,7H,1-2,6H2,(H,16,20) JSRQZDANZDRJOA-UHFFFAOYSA-N 50548834 CHEMBL4786053 Serine/threonine-protein kinase PLK1 Homo sapiens 770 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548834&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667407 461679174 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357513 C[C@H]1C[C@@H]1n1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548900 CHEMBL4750016 Serine/threonine-protein kinase PLK1 Homo sapiens 1190 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548900&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162651097 461679240 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357514 Fc1ccc2c(c1)c(=O)n(CCc1ccccc1Cl)c1n[nH]c(=S)n21 InChI=1S/C17H12ClFN4OS/c18-13-4-2-1-3-10(13)7-8-22-15(24)12-9-11(19)5-6-14(12)23-16(22)20-21-17(23)25/h1-6,9H,7-8H2,(H,21,25) BCWCCLYQOIMHQZ-UHFFFAOYSA-N 50548901 CHEMBL4760146 Serine/threonine-protein kinase PLK1 Homo sapiens 14370 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548901&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162658417 461679241 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357515 Fc1ccc2c(c1)c(=O)n(CCc1ccc(Cl)cc1)c1n[nH]c(=S)n21 InChI=1S/C17H12ClFN4OS/c18-11-3-1-10(2-4-11)7-8-22-15(24)13-9-12(19)5-6-14(13)23-16(22)20-21-17(23)25/h1-6,9H,7-8H2,(H,21,25) OIEUULLHZMEIQJ-UHFFFAOYSA-N 50548902 CHEMBL4748084 Serine/threonine-protein kinase PLK1 Homo sapiens 5710 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548902&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650058 461679242 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357516 Fc1ccc2c(c1)c(=O)n(CCc1ccccn1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-10-4-5-13-12(9-10)14(23)21(15-19-20-16(24)22(13)15)8-6-11-3-1-2-7-18-11/h1-5,7,9H,6,8H2,(H,20,24) DKCRYDVGUXVEGT-UHFFFAOYSA-N 50548903 CHEMBL4755098 Serine/threonine-protein kinase PLK1 Homo sapiens 870 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548903&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654749 461679243 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357517 Fc1ccc2c(c1)c(=O)n(CCc1cccnc1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-11-3-4-13-12(8-11)14(23)21(15-19-20-16(24)22(13)15)7-5-10-2-1-6-18-9-10/h1-4,6,8-9H,5,7H2,(H,20,24) WKMISPZKBDDFFG-UHFFFAOYSA-N 50548904 CHEMBL4789412 Serine/threonine-protein kinase PLK1 Homo sapiens 1070 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548904&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668665 461679244 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357518 Fc1ccc2c(c1)c(=O)n(CCc1ccncc1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-11-1-2-13-12(9-11)14(23)21(15-19-20-16(24)22(13)15)8-5-10-3-6-18-7-4-10/h1-4,6-7,9H,5,8H2,(H,20,24) ZMGSXMDCXVONSV-UHFFFAOYSA-N 50548905 CHEMBL4755584 Serine/threonine-protein kinase PLK1 Homo sapiens 890 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548905&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656087 461679245 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357519 CC(C)(C)OC(=O)N1CC(CCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)C1 InChI=1S/C19H22FN5O3S/c1-19(2,3)28-18(27)23-9-11(10-23)6-7-24-15(26)13-8-12(20)4-5-14(13)25-16(24)21-22-17(25)29/h4-5,8,11H,6-7,9-10H2,1-3H3,(H,22,29) YQPWEPIHGPBEJY-UHFFFAOYSA-N 50548906 CHEMBL4756117 Serine/threonine-protein kinase PLK1 Homo sapiens 5670 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548906&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656006 461679246 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357520 CN1CCCC1CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548907 CHEMBL4745295 Serine/threonine-protein kinase PLK1 Homo sapiens 5670 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548907&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162647550 461679247 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357521 Fc1ccc2c(c1)c(=O)n(CCN1CCCCC1)c1n[nH]c(=S)n21 InChI=1S/C16H18FN5OS/c17-11-4-5-13-12(10-11)14(23)21(15-18-19-16(24)22(13)15)9-8-20-6-2-1-3-7-20/h4-5,10H,1-3,6-9H2,(H,19,24) YXGKVGCKFWARNG-UHFFFAOYSA-N 50548908 CHEMBL4762683 Serine/threonine-protein kinase PLK1 Homo sapiens 1510 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548908&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659781 461679248 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357522 Fc1ccc2c(c1)c(=O)n(CCN1CCC(F)(F)CC1)c1n[nH]c(=S)n21 InChI=1S/C16H16F3N5OS/c17-10-1-2-12-11(9-10)13(25)23(14-20-21-15(26)24(12)14)8-7-22-5-3-16(18,19)4-6-22/h1-2,9H,3-8H2,(H,21,26) DSAGYMBRXXAGLY-UHFFFAOYSA-N 50548909 CHEMBL4758964 Serine/threonine-protein kinase PLK1 Homo sapiens 1370 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548909&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657667 461679249 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357523 Fc1ccc2c(c1)c(=O)n(CCN1CCOCC1)c1n[nH]c(=S)n21 InChI=1S/C15H16FN5O2S/c16-10-1-2-12-11(9-10)13(22)20(14-17-18-15(24)21(12)14)4-3-19-5-7-23-8-6-19/h1-2,9H,3-8H2,(H,18,24) IAGFGMNTHAVBKQ-UHFFFAOYSA-N 50548910 CHEMBL4776438 Serine/threonine-protein kinase PLK1 Homo sapiens 1630 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548910&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162642990 461679250 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357524 CN1CCN(CCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)CC1 InChI=1S/C16H19FN6OS/c1-20-4-6-21(7-5-20)8-9-22-14(24)12-10-11(17)2-3-13(12)23-15(22)18-19-16(23)25/h2-3,10H,4-9H2,1H3,(H,19,25) LVSISVIBJUEAPP-UHFFFAOYSA-N 50548911 CHEMBL4753166 Serine/threonine-protein kinase PLK1 Homo sapiens 6720 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548911&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162653654 461679251 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357525 CC(C)(C)OC(=O)N1CCN(CCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)CC1 InChI=1S/C20H25FN6O3S/c1-20(2,3)30-19(29)25-9-6-24(7-10-25)8-11-26-16(28)14-12-13(21)4-5-15(14)27-17(26)22-23-18(27)31/h4-5,12H,6-11H2,1-3H3,(H,23,31) BPUVBJZPYYTFDJ-UHFFFAOYSA-N 50548912 CHEMBL4756791 Serine/threonine-protein kinase PLK1 Homo sapiens 1840 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548912&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655841 461679252 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357526 Fc1ccc2c(c1)c(=O)n(CCC1CCC(F)(F)CC1)c1n[nH]c(=S)n21 InChI=1S/C17H17F3N4OS/c18-11-1-2-13-12(9-11)14(25)23(15-21-22-16(26)24(13)15)8-5-10-3-6-17(19,20)7-4-10/h1-2,9-10H,3-8H2,(H,22,26) SMSXXOCVHDEVRC-UHFFFAOYSA-N 50548913 CHEMBL4791849 Serine/threonine-protein kinase PLK1 Homo sapiens 2830 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548913&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162671203 461679253 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357527 NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C23H33FN6O6S/c24-17-2-3-19-18(16-17)21(32)29(22-27-28-23(37)30(19)22)7-1-6-26-20(31)4-8-33-10-12-35-14-15-36-13-11-34-9-5-25/h2-3,16H,1,4-15,25H2,(H,26,31)(H,28,37) HTUISLORSNIXSN-UHFFFAOYSA-N 50548914 CHEMBL4784833 Serine/threonine-protein kinase PLK1 Homo sapiens 5360 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162666368 461679254 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357528 CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C28H41FN6O8S/c1-28(2,3)43-27(38)31-9-12-40-14-16-42-18-17-41-15-13-39-11-7-23(36)30-8-4-10-34-24(37)21-19-20(29)5-6-22(21)35-25(34)32-33-26(35)44/h5-6,19H,4,7-18H2,1-3H3,(H,30,36)(H,31,38)(H,33,44) BRFGJROSYKQLMG-UHFFFAOYSA-N 50548915 CHEMBL4778069 Serine/threonine-protein kinase PLK1 Homo sapiens 3220 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644471 461679255 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357529 N[C@@H](CCC(O)=O)C(=O)NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548916 CHEMBL4780772 Serine/threonine-protein kinase PLK1 Homo sapiens 13130 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548916&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662450 461679256 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357530 CC(C)(C)OC(=O)CC[C@H](N)C(=O)NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548917 CHEMBL4762021 Serine/threonine-protein kinase PLK1 Homo sapiens 9400 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548917&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659553 461679257 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357531 NCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C21H29FN6O5S/c22-15-2-3-17-16(14-15)19(30)27(20-25-26-21(34)28(17)20)7-1-6-24-18(29)4-8-31-10-12-33-13-11-32-9-5-23/h2-3,14H,1,4-13,23H2,(H,24,29)(H,26,34) OAUOUODYDIVWSJ-UHFFFAOYSA-N 50548918 CHEMBL4761447 Serine/threonine-protein kinase PLK1 Homo sapiens 5020 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548918&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162660095 461679258 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357532 CC(C)(C)OC(=O)NCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C26H37FN6O7S/c1-26(2,3)40-25(36)29-9-12-38-14-16-39-15-13-37-11-7-21(34)28-8-4-10-32-22(35)19-17-18(27)5-6-20(19)33-23(32)30-31-24(33)41/h5-6,17H,4,7-16H2,1-3H3,(H,28,34)(H,29,36)(H,31,41) PJJZFIBVFHIINE-UHFFFAOYSA-N 50548919 CHEMBL4798911 Serine/threonine-protein kinase PLK1 Homo sapiens 2880 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675900 461679259 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357533 NCCCCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C18H23FN6O2S/c19-12-6-7-14-13(11-12)16(27)24(17-22-23-18(28)25(14)17)10-4-9-21-15(26)5-2-1-3-8-20/h6-7,11H,1-5,8-10,20H2,(H,21,26)(H,23,28) NPRUYNMTXRGZCY-UHFFFAOYSA-N 50548920 CHEMBL4787926 Serine/threonine-protein kinase PLK1 Homo sapiens 3040 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548920&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669090 461679260 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357534 CC(C)(C)OC(=O)NCCCCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C23H31FN6O4S/c1-23(2,3)34-22(33)26-11-6-4-5-8-18(31)25-12-7-13-29-19(32)16-14-15(24)9-10-17(16)30-20(29)27-28-21(30)35/h9-10,14H,4-8,11-13H2,1-3H3,(H,25,31)(H,26,33)(H,28,35) UXODQXNDFBWBFG-UHFFFAOYSA-N 50548921 CHEMBL4759486 Serine/threonine-protein kinase PLK1 Homo sapiens 3230 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548921&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657883 461679261 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357535 CC(C)(C)OC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548922 CHEMBL4749397 Serine/threonine-protein kinase PLK1 Homo sapiens 8190 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548922&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162651408 461679262 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357536 CC(C)(C)OC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548923 CHEMBL4742063 Serine/threonine-protein kinase PLK1 Homo sapiens 3310 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548923&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646701 461679263 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357537 CC(C)(C)OC(=O)CC[C@H](N)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548924 CHEMBL4794603 Serine/threonine-protein kinase PLK1 Homo sapiens 2330 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548924&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674321 461679264 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357538 N[C@@H](CCC(O)=O)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548925 CHEMBL4776697 Serine/threonine-protein kinase PLK1 Homo sapiens 12650 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548925&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643153 461679265 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357539 OC(=O)CCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C16H16FN5O4S/c17-9-2-3-11-10(8-9)14(26)21(15-19-20-16(27)22(11)15)7-1-6-18-12(23)4-5-13(24)25/h2-3,8H,1,4-7H2,(H,18,23)(H,20,27)(H,24,25) BLXWQQCERCCKQU-UHFFFAOYSA-N 50548926 CHEMBL4764548 Serine/threonine-protein kinase PLK1 Homo sapiens 5050 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548926&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662199 461679266 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357540 NS(=O)(=O)CCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C16H19FN6O4S2/c17-10-4-5-12-11(9-10)14(25)22(15-20-21-16(28)23(12)15)7-2-6-19-13(24)3-1-8-29(18,26)27/h4-5,9H,1-3,6-8H2,(H,19,24)(H,21,28)(H2,18,26,27) PWGLZWTVFBLIDR-UHFFFAOYSA-N 50548927 CHEMBL4777570 Serine/threonine-protein kinase PLK1 Homo sapiens 2180 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548927&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644402 461679267 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357541 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCCC1)c1n[nH]c(=S)n21 InChI=1S/C18H20FN5O2S/c19-12-6-7-14-13(10-12)16(26)23(17-21-22-18(27)24(14)17)9-3-8-20-15(25)11-4-1-2-5-11/h6-7,10-11H,1-5,8-9H2,(H,20,25)(H,22,27) OKQDPRMSQDTVMY-UHFFFAOYSA-N 50548928 CHEMBL4795697 Serine/threonine-protein kinase PLK1 Homo sapiens 1470 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548928&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162673236 461679268 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357542 CC(C)(C)[C@H]1CC[C@@H](CC1)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548929 CHEMBL4754725 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548929&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654546 461679269 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357543 CC(C)(C)OC(=O)NC1CCC(CC1)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C24H31FN6O4S/c1-24(2,3)35-23(34)27-16-8-5-14(6-9-16)19(32)26-11-4-12-30-20(33)17-13-15(25)7-10-18(17)31-21(30)28-29-22(31)36/h7,10,13-14,16H,4-6,8-9,11-12H2,1-3H3,(H,26,32)(H,27,34)(H,29,36) HSQIWIFWKHJOJB-UHFFFAOYSA-N 50548930 CHEMBL4762825 Serine/threonine-protein kinase PLK1 Homo sapiens 2380 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659361 461679270 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357544 NC1CCC(CC1)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C19H23FN6O2S/c20-12-4-7-15-14(10-12)17(28)25(18-23-24-19(29)26(15)18)9-1-8-22-16(27)11-2-5-13(21)6-3-11/h4,7,10-11,13H,1-3,5-6,8-9,21H2,(H,22,27)(H,24,29) XBMOWNBEYVKSPR-UHFFFAOYSA-N 50548931 CHEMBL4777157 Serine/threonine-protein kinase PLK1 Homo sapiens 3970 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643787 461679271 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357545 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCCCN1)c1n[nH]c(=S)n21 50548932 CHEMBL4786323 Serine/threonine-protein kinase PLK1 Homo sapiens 27660 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667029 461679272 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357546 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCCNC1)c1n[nH]c(=S)n21 50548933 CHEMBL4754165 Serine/threonine-protein kinase PLK1 Homo sapiens 30200 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548933&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654172 461679273 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357547 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCNCC1)c1n[nH]c(=S)n21 InChI=1S/C18H21FN6O2S/c19-12-2-3-14-13(10-12)16(27)24(17-22-23-18(28)25(14)17)9-1-6-21-15(26)11-4-7-20-8-5-11/h2-3,10-11,20H,1,4-9H2,(H,21,26)(H,23,28) QYWNDJFLOZNZMQ-UHFFFAOYSA-N 50548934 CHEMBL4797067 Serine/threonine-protein kinase PLK1 Homo sapiens 44010 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548934&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162676341 461679274 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357548 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCOCC1)c1n[nH]c(=S)n21 InChI=1S/C18H20FN5O3S/c19-12-2-3-14-13(10-12)16(26)23(17-21-22-18(28)24(14)17)7-1-6-20-15(25)11-4-8-27-9-5-11/h2-3,10-11H,1,4-9H2,(H,20,25)(H,22,28) YIUUGCPBTCTHAZ-UHFFFAOYSA-N 50548935 CHEMBL4785254 Serine/threonine-protein kinase PLK1 Homo sapiens 1790 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548935&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665418 461679275 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357549 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)CC1CCNCC1)c1n[nH]c(=S)n21 InChI=1S/C19H23FN6O2S/c20-13-2-3-15-14(11-13)17(28)25(18-23-24-19(29)26(15)18)9-1-6-22-16(27)10-12-4-7-21-8-5-12/h2-3,11-12,21H,1,4-10H2,(H,22,27)(H,24,29) QODICCGCPVNPQA-UHFFFAOYSA-N 50548936 CHEMBL4762260 Serine/threonine-protein kinase PLK1 Homo sapiens 3960 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548936&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659561 461679276 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357550 CN1CCN(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)CC1 InChI=1S/C19H24FN7O2S/c1-24-7-9-25(10-8-24)12-16(28)21-5-2-6-26-17(29)14-11-13(20)3-4-15(14)27-18(26)22-23-19(27)30/h3-4,11H,2,5-10,12H2,1H3,(H,21,28)(H,23,30) CLIKJUGKPVXNGK-UHFFFAOYSA-N 50548937 CHEMBL4756781 Serine/threonine-protein kinase PLK1 Homo sapiens 4660 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548937&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655709 461679277 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357551 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)CN1CCOCC1)c1n[nH]c(=S)n21 InChI=1S/C18H21FN6O3S/c19-12-2-3-14-13(10-12)16(27)24(17-21-22-18(29)25(14)17)5-1-4-20-15(26)11-23-6-8-28-9-7-23/h2-3,10H,1,4-9,11H2,(H,20,26)(H,22,29) KOMUBOJHKISIJW-UHFFFAOYSA-N 50548938 CHEMBL4796001 Serine/threonine-protein kinase PLK1 Homo sapiens 3770 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548938&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674133 461679278 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357552 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)c1ccc(Cn3ccnc3)cc1)c1n[nH]c(=S)n21 InChI=1S/C23H20FN7O2S/c24-17-6-7-19-18(12-17)21(33)30(22-27-28-23(34)31(19)22)10-1-8-26-20(32)16-4-2-15(3-5-16)13-29-11-9-25-14-29/h2-7,9,11-12,14H,1,8,10,13H2,(H,26,32)(H,28,34) DIJLNXGHNDEKNB-UHFFFAOYSA-N 50548939 CHEMBL4789824 Serine/threonine-protein kinase PLK1 Homo sapiens 1480 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548939&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669731 461679279 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357553 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C20H18FN5O2S/c21-14-7-8-16-15(12-14)18(28)25(19-23-24-20(29)26(16)19)10-4-9-22-17(27)11-13-5-2-1-3-6-13/h1-3,5-8,12H,4,9-11H2,(H,22,27)(H,24,29) ZJAJTDFDSZMRDT-UHFFFAOYSA-N 50548940 CHEMBL4791970 Serine/threonine-protein kinase PLK1 Homo sapiens 1230 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548940&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162670458 461679280 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357554 Cc1noc(C)c1CCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C20H21FN6O3S/c1-11-14(12(2)30-25-11)5-7-17(28)22-8-3-9-26-18(29)15-10-13(21)4-6-16(15)27-19(26)23-24-20(27)31/h4,6,10H,3,5,7-9H2,1-2H3,(H,22,28)(H,24,31) KSKPPJNANLJXSI-UHFFFAOYSA-N 50548941 CHEMBL4741217 Serine/threonine-protein kinase PLK1 Homo sapiens 1780 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548941&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162645925 461679281 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357555 Fc1cccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)c1 InChI=1S/C20H17F2N5O2S/c21-13-4-1-3-12(9-13)10-17(28)23-7-2-8-26-18(29)15-11-14(22)5-6-16(15)27-19(26)24-25-20(27)30/h1,3-6,9,11H,2,7-8,10H2,(H,23,28)(H,25,30) MFZIKBQATZKNJE-UHFFFAOYSA-N 50548942 CHEMBL4757497 Serine/threonine-protein kinase PLK1 Homo sapiens 1420 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548942&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656981 461679282 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357556 Fc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C20H17F2N5O2S/c21-13-4-2-12(3-5-13)10-17(28)23-8-1-9-26-18(29)15-11-14(22)6-7-16(15)27-19(26)24-25-20(27)30/h2-7,11H,1,8-10H2,(H,23,28)(H,25,30) WAZDLRSDVCWIQX-UHFFFAOYSA-N 50548943 CHEMBL4785186 Serine/threonine-protein kinase PLK1 Homo sapiens 1350 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548943&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162666393 461679283 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357557 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1cccc(Cl)c1)c1n[nH]c(=S)n21 InChI=1S/C20H17ClFN5O2S/c21-13-4-1-3-12(9-13)10-17(28)23-7-2-8-26-18(29)15-11-14(22)5-6-16(15)27-19(26)24-25-20(27)30/h1,3-6,9,11H,2,7-8,10H2,(H,23,28)(H,25,30) DUTLBYFPUBZPJS-UHFFFAOYSA-N 50548944 CHEMBL4754571 Serine/threonine-protein kinase PLK1 Homo sapiens 1150 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548944&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654702 461679284 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357558 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccc(Br)cc1)c1n[nH]c(=S)n21 InChI=1S/C20H17BrFN5O2S/c21-13-4-2-12(3-5-13)10-17(28)23-8-1-9-26-18(29)15-11-14(22)6-7-16(15)27-19(26)24-25-20(27)30/h2-7,11H,1,8-10H2,(H,23,28)(H,25,30) CWGRKPQEWRYLLL-UHFFFAOYSA-N 50548945 CHEMBL4741770 Serine/threonine-protein kinase PLK1 Homo sapiens 1590 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548945&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162647140 461679285 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357559 Cc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C21H20FN5O2S/c1-13-3-5-14(6-4-13)11-18(28)23-9-2-10-26-19(29)16-12-15(22)7-8-17(16)27-20(26)24-25-21(27)30/h3-8,12H,2,9-11H2,1H3,(H,23,28)(H,25,30) ZMBLMPPSRRFODO-UHFFFAOYSA-N 50548946 CHEMBL4762177 Serine/threonine-protein kinase PLK1 Homo sapiens 1180 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548946&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162660794 461679286 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357560 Oc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C20H18FN5O3S/c21-13-4-7-16-15(11-13)18(29)25(19-23-24-20(30)26(16)19)9-1-8-22-17(28)10-12-2-5-14(27)6-3-12/h2-7,11,27H,1,8-10H2,(H,22,28)(H,24,30) RAJFIPOIYIBRSD-UHFFFAOYSA-N 50548947 CHEMBL4742821 Serine/threonine-protein kinase PLK1 Homo sapiens 1160 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548947&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646556 461679287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357561 COc1ccccc1CC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C21H20FN5O3S/c1-30-17-6-3-2-5-13(17)11-18(28)23-9-4-10-26-19(29)15-12-14(22)7-8-16(15)27-20(26)24-25-21(27)31/h2-3,5-8,12H,4,9-11H2,1H3,(H,23,28)(H,25,31) WWLSVTKNNQDUMY-UHFFFAOYSA-N 50548948 CHEMBL4781698 Serine/threonine-protein kinase PLK1 Homo sapiens 1150 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548948&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664244 461679288 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357562 COc1cccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)c1 InChI=1S/C21H20FN5O3S/c1-30-15-5-2-4-13(10-15)11-18(28)23-8-3-9-26-19(29)16-12-14(22)6-7-17(16)27-20(26)24-25-21(27)31/h2,4-7,10,12H,3,8-9,11H2,1H3,(H,23,28)(H,25,31) ARRRHZTVWRSLIH-UHFFFAOYSA-N 50548949 CHEMBL4782750 Serine/threonine-protein kinase PLK1 Homo sapiens 960 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548949&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664368 461679289 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357563 COc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C21H20FN5O3S/c1-30-15-6-3-13(4-7-15)11-18(28)23-9-2-10-26-19(29)16-12-14(22)5-8-17(16)27-20(26)24-25-21(27)31/h3-8,12H,2,9-11H2,1H3,(H,23,28)(H,25,31) LOVNVBBMCJEQCJ-UHFFFAOYSA-N 50548950 CHEMBL4745902 Serine/threonine-protein kinase PLK1 Homo sapiens 1060 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548950&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162648892 461679290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357564 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccc1C(F)(F)F)c1n[nH]c(=S)n21 InChI=1S/C21H17F4N5O2S/c22-13-6-7-16-14(11-13)18(32)29(19-27-28-20(33)30(16)19)9-3-8-26-17(31)10-12-4-1-2-5-15(12)21(23,24)25/h1-2,4-7,11H,3,8-10H2,(H,26,31)(H,28,33) CCASXWFAFBFAEM-UHFFFAOYSA-N 50548951 CHEMBL4753107 Serine/threonine-protein kinase PLK1 Homo sapiens 1400 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548951&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654023 461679291 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357565 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1cccc(c1)C(F)(F)F)c1n[nH]c(=S)n21 InChI=1S/C21H17F4N5O2S/c22-14-5-6-16-15(11-14)18(32)29(19-27-28-20(33)30(16)19)8-2-7-26-17(31)10-12-3-1-4-13(9-12)21(23,24)25/h1,3-6,9,11H,2,7-8,10H2,(H,26,31)(H,28,33) JTGQNDUYFYKNEC-UHFFFAOYSA-N 50548952 CHEMBL4795057 Serine/threonine-protein kinase PLK1 Homo sapiens 2230 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548952&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675491 461679292 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357566 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccc1C#N)c1n[nH]c(=S)n21 InChI=1S/C21H17FN6O2S/c22-15-6-7-17-16(11-15)19(30)27(20-25-26-21(31)28(17)20)9-3-8-24-18(29)10-13-4-1-2-5-14(13)12-23/h1-2,4-7,11H,3,8-10H2,(H,24,29)(H,26,31) WVGGYGFBIMIPTH-UHFFFAOYSA-N 50548953 CHEMBL4786880 Serine/threonine-protein kinase PLK1 Homo sapiens 1240 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548953&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667136 461679293 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357567 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccc(cc1)C#N)c1n[nH]c(=S)n21 InChI=1S/C21H17FN6O2S/c22-15-6-7-17-16(11-15)19(30)27(20-25-26-21(31)28(17)20)9-1-8-24-18(29)10-13-2-4-14(12-23)5-3-13/h2-7,11H,1,8-10H2,(H,24,29)(H,26,31) OCVKYBDQGXTDAN-UHFFFAOYSA-N 50548954 CHEMBL4779347 Serine/threonine-protein kinase PLK1 Homo sapiens 990 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548954&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663133 461679294 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357568 CC(C)(C)OC(=O)Nc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C25H27FN6O4S/c1-25(2,3)36-24(35)28-17-8-5-15(6-9-17)13-20(33)27-11-4-12-31-21(34)18-14-16(26)7-10-19(18)32-22(31)29-30-23(32)37/h5-10,14H,4,11-13H2,1-3H3,(H,27,33)(H,28,35)(H,30,37) AKGYWCZMZBGMDX-UHFFFAOYSA-N 50548955 CHEMBL4782976 Serine/threonine-protein kinase PLK1 Homo sapiens 2720 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548955&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665164 461679295 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357569 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccn1)c1n[nH]c(=S)n21 InChI=1S/C19H17FN6O2S/c20-12-5-6-15-14(10-12)17(28)25(18-23-24-19(29)26(15)18)9-3-8-22-16(27)11-13-4-1-2-7-21-13/h1-2,4-7,10H,3,8-9,11H2,(H,22,27)(H,24,29) OFSLVXWAMBVHNF-UHFFFAOYSA-N 50548956 CHEMBL4799166 Serine/threonine-protein kinase PLK1 Homo sapiens 5340 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548956&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674799 461679296 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357570 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1cccnc1)c1n[nH]c(=S)n21 InChI=1S/C19H17FN6O2S/c20-13-4-5-15-14(10-13)17(28)25(18-23-24-19(29)26(15)18)8-2-7-22-16(27)9-12-3-1-6-21-11-12/h1,3-6,10-11H,2,7-9H2,(H,22,27)(H,24,29) DOQXTXOFMUXBQO-UHFFFAOYSA-N 50548957 CHEMBL4747182 Serine/threonine-protein kinase PLK1 Homo sapiens 2500 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548957&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649947 461679297 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357571 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccncc1)c1n[nH]c(=S)n21 InChI=1S/C19H17FN6O2S/c20-13-2-3-15-14(11-13)17(28)25(18-23-24-19(29)26(15)18)9-1-6-22-16(27)10-12-4-7-21-8-5-12/h2-5,7-8,11H,1,6,9-10H2,(H,22,27)(H,24,29) OCNYRTDIUVCJLS-UHFFFAOYSA-N 50548958 CHEMBL4761120 Serine/threonine-protein kinase PLK1 Homo sapiens 3010 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548958&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659684 461679298 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357572 CCCn1c2n[nH]c(=S)n2c2c(F)cccc2c1=O InChI=1S/C12H11FN4OS/c1-2-6-16-10(18)7-4-3-5-8(13)9(7)17-11(16)14-15-12(17)19/h3-5H,2,6H2,1H3,(H,15,19) XBKUXOLIYAXVGG-UHFFFAOYSA-N 50548959 CHEMBL4758334 Serine/threonine-protein kinase PLK1 Homo sapiens 2060 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548959&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656377 461679299 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357573 CCCn1c2n[nH]c(=S)n2c2c(Cl)cccc2c1=O InChI=1S/C12H11ClN4OS/c1-2-6-16-10(18)7-4-3-5-8(13)9(7)17-11(16)14-15-12(17)19/h3-5H,2,6H2,1H3,(H,15,19) PTFZQKOKWSGNMN-UHFFFAOYSA-N 50548960 CHEMBL4797725 Serine/threonine-protein kinase PLK1 Homo sapiens 2490 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548960&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675963 461679300 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357574 CCCn1c2n[nH]c(=S)n2c2c(OC)cccc2c1=O InChI=1S/C13H14N4O2S/c1-3-7-16-11(18)8-5-4-6-9(19-2)10(8)17-12(16)14-15-13(17)20/h4-6H,3,7H2,1-2H3,(H,15,20) KBSVZLHQKCTESW-UHFFFAOYSA-N 50548961 CHEMBL4747386 Serine/threonine-protein kinase PLK1 Homo sapiens 2430 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548961&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650368 461679301 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357575 CCCn1c2nnc(SC(C)=O)n2c2ccccc2c1=O InChI=1S/C14H14N4O2S/c1-3-8-17-12(20)10-6-4-5-7-11(10)18-13(17)15-16-14(18)21-9(2)19/h4-7H,3,8H2,1-2H3 BNYKCYPINRXOND-UHFFFAOYSA-N 50548962 CHEMBL4748570 Serine/threonine-protein kinase PLK1 Homo sapiens 1330 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548962&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650532 461679302 C04334 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357576 CCCn1c2nnc(SC)n2c2ccccc2c1=O InChI=1S/C13H14N4OS/c1-3-8-16-11(18)9-6-4-5-7-10(9)17-12(16)14-15-13(17)19-2/h4-7H,3,8H2,1-2H3 QCMQLIPWNDLWDB-UHFFFAOYSA-N 91532 1-(methylthio)-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one::1-methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS-0471508.0001::cid_16370143 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=91532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=91532&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16370143 252663057 ZINC09882276 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357577 CCCn1c2nnc(SC)n2c2ccc(F)cc2c1=O InChI=1S/C13H13FN4OS/c1-3-6-17-11(19)9-7-8(14)4-5-10(9)18-12(17)15-16-13(18)20-2/h4-5,7H,3,6H2,1-2H3 WDDVKESXYYVHRR-UHFFFAOYSA-N 50548963 CHEMBL4753937 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548963&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654583 461679303 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357578 CCCn1c2nnc(SC)n2c2c(F)cccc2c1=O InChI=1S/C13H13FN4OS/c1-3-7-17-11(19)8-5-4-6-9(14)10(8)18-12(17)15-16-13(18)20-2/h4-6H,3,7H2,1-2H3 NYTBRBJXPKJNBN-UHFFFAOYSA-N 50548964 CHEMBL4741356 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548964&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162645453 461679304 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357579 CCCn1c2nnc(SC)n2c2c(Cl)cccc2c1=O InChI=1S/C13H13ClN4OS/c1-3-7-17-11(19)8-5-4-6-9(14)10(8)18-12(17)15-16-13(18)20-2/h4-6H,3,7H2,1-2H3 VQEXWWQSLDYNBF-UHFFFAOYSA-N 50548965 CHEMBL4789082 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548965&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668543 461679305 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51357580 CCCn1c2nnc(SC)n2c2c(OC)cccc2c1=O InChI=1S/C14H16N4O2S/c1-4-8-17-12(19)9-6-5-7-10(20-2)11(9)18-13(17)15-16-14(18)21-3/h5-7H,4,8H2,1-3H3 LUUOYBKUMHZMOW-UHFFFAOYSA-N 50548966 CHEMBL4751005 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01669 10.7270/Q2R49VDZ 33175530 Alverez, CN; Park, JE; Toti, KS; Xia, Y; Krausz, KW; Rai, G; Bang, JK; Gonzalez, FJ; Jacobson, KA; Lee, KS National Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548966&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162651155 461679306 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51359545 COc1cc(ccc1Nc1ncc2N(C)C(=O)c3nc(C)sc3N(C)c2n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C28H37N9O2S/c1-18-30-24-26(38)34(3)22-17-29-28(32-25(22)35(4)27(24)40-18)31-21-7-6-20(16-23(21)39-5)36-10-8-19(9-11-36)37-14-12-33(2)13-15-37/h6-7,16-17,19H,8-15H2,1-5H3,(H,29,31,32) CRIXVDLWVWCQCE-UHFFFAOYSA-N 50549740 CHEMBL4752723 Serine/threonine-protein kinase PLK1 Homo sapiens 8300 ChEMBL 10.1021/acsmedchemlett.0c00338 10.7270/Q2DJ5K8C 33488961 Groendyke, BJ; Nabet, B; Mohardt, ML; Zhang, H; Peng, K; Koide, E; Coffey, CR; Che, J; Scott, DA; Bass, AJ; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549740&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162406108 461680080 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51359903 Cc1nc(NC(=O)NCCc2cn(CC(F)F)cn2)sc1C#Cc1cccnc1 InChI=1S/C19H18F2N6OS/c1-13-16(5-4-14-3-2-7-22-9-14)29-19(25-13)26-18(28)23-8-6-15-10-27(12-24-15)11-17(20)21/h2-3,7,9-10,12,17H,6,8,11H2,1H3,(H2,23,25,26,28) FUKVQYDAJUEJHW-UHFFFAOYSA-N 50549828 CHEMBL4795990 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549828&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49847093 461680168 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51359904 COc1cc(cnc1OC)C#Cc1sc(NC(=O)NCCOCC2CC2)nc1C InChI=1S/C20H24N4O4S/c1-13-17(7-6-15-10-16(26-2)18(27-3)22-11-15)29-20(23-13)24-19(25)21-8-9-28-12-14-4-5-14/h10-11,14H,4-5,8-9,12H2,1-3H3,(H2,21,23,24,25) NXINHUNNPLATCI-UHFFFAOYSA-N 50549837 CHEMBL4759283 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 59615740 461680177 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51359905 Cc1nc(NC(=O)NCCOCC2CC2)sc1C#Cc1ccc2cncn2c1 InChI=1S/C20H21N5O2S/c1-14-18(7-5-15-4-6-17-10-21-13-25(17)11-15)28-20(23-14)24-19(26)22-8-9-27-12-16-2-3-16/h4,6,10-11,13,16H,2-3,8-9,12H2,1H3,(H2,22,23,24,26) HSBRXTBEKJPMLK-UHFFFAOYSA-N 50549846 CHEMBL4764646 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549846&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162661364 461680186 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51359906 C[C@@H](CNC(=O)Nc1nc(C)c(s1)C#Cc1cncc(C)c1)OCC1CC1 InChI=1S/C20H24N4O2S/c1-13-8-17(11-21-9-13)6-7-18-15(3)23-20(27-18)24-19(25)22-10-14(2)26-12-16-4-5-16/h8-9,11,14,16H,4-5,10,12H2,1-3H3,(H2,22,23,24,25)/t14-/m0/s1 MFIXITNFFHIALQ-AWEZNQCLSA-N 50549854 CHEMBL4784202 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549854&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665555 461680194 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51359907 C[C@@H](CNC(=O)Nc1nc(C)c(s1)C#Cc1cnc(C)c(C)c1)OCC1CC1 InChI=1S/C21H26N4O2S/c1-13-9-18(11-22-15(13)3)7-8-19-16(4)24-21(28-19)25-20(26)23-10-14(2)27-12-17-5-6-17/h9,11,14,17H,5-6,10,12H2,1-4H3,(H2,23,24,25,26)/t14-/m0/s1 OZANXNDKKYVVMJ-AWEZNQCLSA-N 50549855 CHEMBL4756664 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549855&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655372 461680195 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400132 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCN(C)CC2)ncc1[N+]([O-])=O InChI=1S/C22H25N7O5S/c1-27-7-9-28(10-8-27)14-4-5-15(18(12-14)33-2)25-22-23-13-17(29(31)32)20(26-22)24-16-6-11-35-19(16)21(30)34-3/h4-6,11-13H,7-10H2,1-3H3,(H2,23,24,25,26) VPAWZGXRVQMSKG-UHFFFAOYSA-N 50565552 CHEMBL4787496 Serine/threonine-protein kinase PLK1 Homo sapiens 4.7 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565552&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667856 461685890 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400133 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCN(C)CC2)ncc1[N+]([O-])=O InChI=1S/C27H34N8O5S/c1-32-11-13-34(14-12-32)18-6-9-33(10-7-18)19-4-5-20(23(16-19)39-2)30-27-28-17-22(35(37)38)25(31-27)29-21-8-15-41-24(21)26(36)40-3/h4-5,8,15-18H,6-7,9-14H2,1-3H3,(H2,28,29,30,31) ZTEVGGKOVLPIEL-UHFFFAOYSA-N 50565553 CHEMBL4783750 Serine/threonine-protein kinase PLK1 Homo sapiens 8.1 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565553&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665546 461685891 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400134 COC(=O)c1sccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1[N+]([O-])=O InChI=1S/C23H25N7O6S/c1-28(2)12-19(31)29-7-5-13-9-18(35-3)15(10-16(13)29)26-23-24-11-17(30(33)34)21(27-23)25-14-6-8-37-20(14)22(32)36-4/h6,8-11H,5,7,12H2,1-4H3,(H2,24,25,26,27) UVPBFWMHQUSPOD-UHFFFAOYSA-N 50565554 CHEMBL4776345 Serine/threonine-protein kinase PLK1 Homo sapiens 6.2 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565554&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643440 461685892 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400135 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1[N+]([O-])=O InChI=1S/C26H31N7O5S/c1-37-22-15-18(32-12-7-17(8-13-32)31-10-3-4-11-31)5-6-19(22)29-26-27-16-21(33(35)36)24(30-26)28-20-9-14-39-23(20)25(34)38-2/h5-6,9,14-17H,3-4,7-8,10-13H2,1-2H3,(H2,27,28,29,30) DWBIEPRODGMHQI-UHFFFAOYSA-N 50565555 CHEMBL4795375 Serine/threonine-protein kinase PLK1 Homo sapiens 1.6 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565555&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674118 461685893 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400136 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2)N2CCC(CC2)N2CCN(C)CC2)ncc1[N+]([O-])=O InChI=1S/C26H32N8O4S/c1-31-12-14-33(15-13-31)20-7-10-32(11-8-20)19-5-3-18(4-6-19)28-26-27-17-22(34(36)37)24(30-26)29-21-9-16-39-23(21)25(35)38-2/h3-6,9,16-17,20H,7-8,10-15H2,1-2H3,(H2,27,28,29,30) AYXGMUALYASCJJ-UHFFFAOYSA-N 50565556 CHEMBL4787929 Serine/threonine-protein kinase PLK1 Homo sapiens <0.508000 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565556&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669092 461685894 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400137 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1[N+]([O-])=O InChI=1S/C21H23N7O4S/c1-26-8-10-27(11-9-26)15-5-3-14(4-6-15)23-21-22-13-17(28(30)31)19(25-21)24-16-7-12-33-18(16)20(29)32-2/h3-7,12-13H,8-11H2,1-2H3,(H2,22,23,24,25) TYMAVIMYWJRWAC-UHFFFAOYSA-N 50565557 CHEMBL4800017 Serine/threonine-protein kinase PLK1 Homo sapiens 4.4 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565557&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162676917 461685895 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400138 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2)N2CCC(O)CC2)ncc1[N+]([O-])=O InChI=1S/C21H22N6O5S/c1-32-20(29)18-16(8-11-33-18)24-19-17(27(30)31)12-22-21(25-19)23-13-2-4-14(5-3-13)26-9-6-15(28)7-10-26/h2-5,8,11-12,15,28H,6-7,9-10H2,1H3,(H2,22,23,24,25) AHSNVOWNCUESGN-UHFFFAOYSA-N 50565558 CHEMBL4783888 Serine/threonine-protein kinase PLK1 Homo sapiens 1.3 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565558&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665343 461685896 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400139 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1[N+]([O-])=O InChI=1S/C24H29N7O5S/c1-29(2)15-7-10-30(11-8-15)16-5-6-17(20(13-16)35-3)27-24-25-14-19(31(33)34)22(28-24)26-18-9-12-37-21(18)23(32)36-4/h5-6,9,12-15H,7-8,10-11H2,1-4H3,(H2,25,26,27,28) JHNUQPPKLNYDNL-UHFFFAOYSA-N 50565559 CHEMBL4792017 Serine/threonine-protein kinase PLK1 Homo sapiens <0.508000 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565559&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162670845 461685897 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400140 COC(=O)c1sccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)ncc1[N+]([O-])=O InChI=1S/C23H24F3N7O4S/c1-31-6-8-32(9-7-31)13-14-3-4-15(11-16(14)23(24,25)26)28-22-27-12-18(33(35)36)20(30-22)29-17-5-10-38-19(17)21(34)37-2/h3-5,10-12H,6-9,13H2,1-2H3,(H2,27,28,29,30) OKGBWJJMHSWNRD-UHFFFAOYSA-N 50565560 CHEMBL4780899 Serine/threonine-protein kinase PLK1 Homo sapiens 4175 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565560&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662466 461685898 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400141 COC(=O)c1ccsc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1[N+]([O-])=O InChI=1S/C23H25N7O6S/c1-28(2)12-19(31)29-7-5-13-9-18(35-3)15(10-16(13)29)25-23-24-11-17(30(33)34)20(27-23)26-21-14(6-8-37-21)22(32)36-4/h6,8-11H,5,7,12H2,1-4H3,(H2,24,25,26,27) QNDWGLFHFHOWDB-UHFFFAOYSA-N 50565561 CHEMBL4799183 Serine/threonine-protein kinase PLK1 Homo sapiens 5.1 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565561&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162677146 461685899 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400142 COC(=O)c1ccsc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1[N+]([O-])=O InChI=1S/C26H31N7O5S/c1-37-22-15-18(32-12-7-17(8-13-32)31-10-3-4-11-31)5-6-20(22)28-26-27-16-21(33(35)36)23(30-26)29-24-19(9-14-39-24)25(34)38-2/h5-6,9,14-17H,3-4,7-8,10-13H2,1-2H3,(H2,27,28,29,30) JRYIWGFHVAAZGD-UHFFFAOYSA-N 50565562 CHEMBL4790807 Serine/threonine-protein kinase PLK1 Homo sapiens 5.3 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565562&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162670937 461685900 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400143 COC(=O)c1ccsc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1[N+]([O-])=O InChI=1S/C24H29N7O5S/c1-29(2)15-7-10-30(11-8-15)16-5-6-18(20(13-16)35-3)26-24-25-14-19(31(33)34)21(28-24)27-22-17(9-12-37-22)23(32)36-4/h5-6,9,12-15H,7-8,10-11H2,1-4H3,(H2,25,26,27,28) WGZVEBLYZDEWLP-UHFFFAOYSA-N 50565563 CHEMBL4781522 Serine/threonine-protein kinase PLK1 Homo sapiens 7.4 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565563&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665064 461685901 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400144 COC(=O)c1ccsc1Nc1nc(Nc2ccc(cc2OC)N2CCN(C)CC2)ncc1[N+]([O-])=O InChI=1S/C22H25N7O5S/c1-27-7-9-28(10-8-27)14-4-5-16(18(12-14)33-2)24-22-23-13-17(29(31)32)19(26-22)25-20-15(6-11-35-20)21(30)34-3/h4-6,11-13H,7-10H2,1-3H3,(H2,23,24,25,26) NEFUPOHGTIRRNR-UHFFFAOYSA-N 50565564 CHEMBL4784781 Serine/threonine-protein kinase PLK1 Homo sapiens 3.7 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565564&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665788 461685902 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400145 COC(=O)c1ccsc1Nc1nc(Nc2ccc(cc2)N2CCN(C)CC2)ncc1[N+]([O-])=O InChI=1S/C21H23N7O4S/c1-26-8-10-27(11-9-26)15-5-3-14(4-6-15)23-21-22-13-17(28(30)31)18(25-21)24-19-16(7-12-33-19)20(29)32-2/h3-7,12-13H,8-11H2,1-2H3,(H2,22,23,24,25) QITOLNUGQPOLDA-UHFFFAOYSA-N 50565565 CHEMBL4796797 Serine/threonine-protein kinase PLK1 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565565&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674575 461685903 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400146 COC(=O)c1scc(C)c1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1[N+]([O-])=O InChI=1S/C24H27N7O6S/c1-13-12-38-21(23(33)37-5)20(13)27-22-17(31(34)35)10-25-24(28-22)26-15-9-16-14(8-18(15)36-4)6-7-30(16)19(32)11-29(2)3/h8-10,12H,6-7,11H2,1-5H3,(H2,25,26,27,28) TZVJXKWZIXMKLI-UHFFFAOYSA-N 50565566 CHEMBL4793185 Serine/threonine-protein kinase PLK1 Homo sapiens 219 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565566&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162671973 461685904 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400147 COC(=O)c1scc(C)c1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1[N+]([O-])=O InChI=1S/C27H33N7O5S/c1-17-16-40-24(26(35)39-3)23(17)30-25-21(34(36)37)15-28-27(31-25)29-20-7-6-19(14-22(20)38-2)33-12-8-18(9-13-33)32-10-4-5-11-32/h6-7,14-16,18H,4-5,8-13H2,1-3H3,(H2,28,29,30,31) NIAMGVHOFKODAA-UHFFFAOYSA-N 50565567 CHEMBL4777753 Serine/threonine-protein kinase PLK1 Homo sapiens 3510 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565567&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644423 461685905 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400148 COC(=O)c1scc(C)c1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1[N+]([O-])=O InChI=1S/C25H31N7O5S/c1-15-14-38-22(24(33)37-5)21(15)28-23-19(32(34)35)13-26-25(29-23)27-18-7-6-17(12-20(18)36-4)31-10-8-16(9-11-31)30(2)3/h6-7,12-14,16H,8-11H2,1-5H3,(H2,26,27,28,29) UNXDRANXNQFLAB-UHFFFAOYSA-N 50565568 CHEMBL4799010 Serine/threonine-protein kinase PLK1 Homo sapiens 4395 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565568&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675185 461685906 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400149 COC(=O)c1ccccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1[N+]([O-])=O InChI=1S/C25H27N7O6/c1-30(2)14-22(33)31-10-9-15-11-21(37-3)18(12-19(15)31)28-25-26-13-20(32(35)36)23(29-25)27-17-8-6-5-7-16(17)24(34)38-4/h5-8,11-13H,9-10,14H2,1-4H3,(H2,26,27,28,29) HJDOOOSZJBAULE-UHFFFAOYSA-N 50565569 CHEMBL4780069 Serine/threonine-protein kinase PLK1 Homo sapiens <0.508000 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565569&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663720 461685907 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400150 COC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1[N+]([O-])=O InChI=1S/C28H33N7O5/c1-39-25-17-20(34-15-11-19(12-16-34)33-13-5-6-14-33)9-10-23(25)31-28-29-18-24(35(37)38)26(32-28)30-22-8-4-3-7-21(22)27(36)40-2/h3-4,7-10,17-19H,5-6,11-16H2,1-2H3,(H2,29,30,31,32) SWYGPJVSFJOFLU-UHFFFAOYSA-N 50565570 CHEMBL4798376 Serine/threonine-protein kinase PLK1 Homo sapiens <0.508000 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565570&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162676281 461685908 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400151 COC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1[N+]([O-])=O InChI=1S/C26H31N7O5/c1-31(2)17-11-13-32(14-12-17)18-9-10-21(23(15-18)37-3)29-26-27-16-22(33(35)36)24(30-26)28-20-8-6-5-7-19(20)25(34)38-4/h5-10,15-17H,11-14H2,1-4H3,(H2,27,28,29,30) ZOORFMZEFHVRCW-UHFFFAOYSA-N 50565571 CHEMBL4790038 Serine/threonine-protein kinase PLK1 Homo sapiens 0.577000 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565571&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669748 461685909 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400152 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 2.4 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400153 COC(=O)c1sccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1C(F)(F)F InChI=1S/C24H25F3N6O4S/c1-32(2)12-19(34)33-7-5-13-9-18(36-3)16(10-17(13)33)30-23-28-11-14(24(25,26)27)21(31-23)29-15-6-8-38-20(15)22(35)37-4/h6,8-11H,5,7,12H2,1-4H3,(H2,28,29,30,31) INSBBZOXHUDXOP-UHFFFAOYSA-N 50565572 CHEMBL4800688 Serine/threonine-protein kinase PLK1 Homo sapiens <0.508000 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565572&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162676791 461685910 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400154 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1C(F)(F)F InChI=1S/C27H31F3N6O3S/c1-38-22-15-18(36-12-7-17(8-13-36)35-10-3-4-11-35)5-6-20(22)33-26-31-16-19(27(28,29)30)24(34-26)32-21-9-14-40-23(21)25(37)39-2/h5-6,9,14-17H,3-4,7-8,10-13H2,1-2H3,(H2,31,32,33,34) AKPUWBRSECFONU-UHFFFAOYSA-N 50565573 CHEMBL4785567 Serine/threonine-protein kinase PLK1 Homo sapiens 3.3 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565573&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667637 461685911 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400155 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1C(F)(F)F InChI=1S/C25H29F3N6O3S/c1-33(2)15-7-10-34(11-8-15)16-5-6-18(20(13-16)36-3)31-24-29-14-17(25(26,27)28)22(32-24)30-19-9-12-38-21(19)23(35)37-4/h5-6,9,12-15H,7-8,10-11H2,1-4H3,(H2,29,30,31,32) BGBVLUCCCDASRT-UHFFFAOYSA-N 50565574 CHEMBL4783122 Serine/threonine-protein kinase PLK1 Homo sapiens 4.6 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565574&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664897 461685912 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400156 COC(=O)c1sccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1C#N InChI=1S/C24H25N7O4S/c1-30(2)13-20(32)31-7-5-14-9-19(34-3)17(10-18(14)31)28-24-26-12-15(11-25)22(29-24)27-16-6-8-36-21(16)23(33)35-4/h6,8-10,12H,5,7,13H2,1-4H3,(H2,26,27,28,29) GMGYGMPNRQZFIW-UHFFFAOYSA-N 50565575 CHEMBL4778422 Serine/threonine-protein kinase PLK1 Homo sapiens 4.9 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565575&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644075 461685913 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400157 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1C#N InChI=1S/C27H31N7O3S/c1-36-23-15-20(34-12-7-19(8-13-34)33-10-3-4-11-33)5-6-21(23)31-27-29-17-18(16-28)25(32-27)30-22-9-14-38-24(22)26(35)37-2/h5-6,9,14-15,17,19H,3-4,7-8,10-13H2,1-2H3,(H2,29,30,31,32) FOXHMOCMCJIDJP-UHFFFAOYSA-N 50565576 CHEMBL4779654 Serine/threonine-protein kinase PLK1 Homo sapiens 3.8 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565576&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663144 461685914 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400158 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1C#N InChI=1S/C25H29N7O3S/c1-31(2)17-7-10-32(11-8-17)18-5-6-19(21(13-18)34-3)29-25-27-15-16(14-26)23(30-25)28-20-9-12-36-22(20)24(33)35-4/h5-6,9,12-13,15,17H,7-8,10-11H2,1-4H3,(H2,27,28,29,30) BPWOAWXCTUHHRX-UHFFFAOYSA-N 50565577 CHEMBL4784741 Serine/threonine-protein kinase PLK1 Homo sapiens 2.7 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565577&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665478 461685915 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400159 COC(=O)c1sccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1F InChI=1S/C23H25FN6O4S/c1-29(2)12-19(31)30-7-5-13-9-18(33-3)16(10-17(13)30)27-23-25-11-14(24)21(28-23)26-15-6-8-35-20(15)22(32)34-4/h6,8-11H,5,7,12H2,1-4H3,(H2,25,26,27,28) DGOGRUKQSGOTOH-UHFFFAOYSA-N 50565578 CHEMBL4793797 Serine/threonine-protein kinase PLK1 Homo sapiens 29 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565578&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162672608 461685916 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400160 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1F InChI=1S/C26H31FN6O3S/c1-35-22-15-18(33-12-7-17(8-13-33)32-10-3-4-11-32)5-6-20(22)30-26-28-16-19(27)24(31-26)29-21-9-14-37-23(21)25(34)36-2/h5-6,9,14-17H,3-4,7-8,10-13H2,1-2H3,(H2,28,29,30,31) YXQYFSFTBNSCOL-UHFFFAOYSA-N 50565579 CHEMBL4777642 Serine/threonine-protein kinase PLK1 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644021 461685917 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400161 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1F InChI=1S/C24H29FN6O3S/c1-30(2)15-7-10-31(11-8-15)16-5-6-18(20(13-16)33-3)28-24-26-14-17(25)22(29-24)27-19-9-12-35-21(19)23(32)34-4/h5-6,9,12-15H,7-8,10-11H2,1-4H3,(H2,26,27,28,29) BJZCPRBXKOPJMP-UHFFFAOYSA-N 50565580 CHEMBL4800439 Serine/threonine-protein kinase PLK1 Homo sapiens 189 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565580&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162677002 461685918 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400162 COC(=O)c1sccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1Br InChI=1S/C23H25BrN6O4S/c1-29(2)12-19(31)30-7-5-13-9-18(33-3)16(10-17(13)30)27-23-25-11-14(24)21(28-23)26-15-6-8-35-20(15)22(32)34-4/h6,8-11H,5,7,12H2,1-4H3,(H2,25,26,27,28) LXDDZRAYUWSVCX-UHFFFAOYSA-N 50565581 CHEMBL4800085 Serine/threonine-protein kinase PLK1 Homo sapiens 4.3 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565581&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162677301 461685919 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400163 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1Br InChI=1S/C26H31BrN6O3S/c1-35-22-15-18(33-12-7-17(8-13-33)32-10-3-4-11-32)5-6-20(22)30-26-28-16-19(27)24(31-26)29-21-9-14-37-23(21)25(34)36-2/h5-6,9,14-17H,3-4,7-8,10-13H2,1-2H3,(H2,28,29,30,31) VZNNKVLNOPJDRD-UHFFFAOYSA-N 50565582 CHEMBL4790028 Serine/threonine-protein kinase PLK1 Homo sapiens 3.4 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565582&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669740 461685920 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400164 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1Br InChI=1S/C24H29BrN6O3S/c1-30(2)15-7-10-31(11-8-15)16-5-6-18(20(13-16)33-3)28-24-26-14-17(25)22(29-24)27-19-9-12-35-21(19)23(32)34-4/h5-6,9,12-15H,7-8,10-11H2,1-4H3,(H2,26,27,28,29) YOJZLNXKODSVJJ-UHFFFAOYSA-N 50565583 CHEMBL4780169 Serine/threonine-protein kinase PLK1 Homo sapiens 1.4 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565583&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663571 461685921 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400165 COC(=O)c1sccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)ncc1C InChI=1S/C24H28N6O4S/c1-14-12-25-24(28-22(14)26-16-7-9-35-21(16)23(32)34-5)27-17-11-18-15(10-19(17)33-4)6-8-30(18)20(31)13-29(2)3/h7,9-12H,6,8,13H2,1-5H3,(H2,25,26,27,28) PAXGWTPYLSVERK-UHFFFAOYSA-N 50565584 CHEMBL4778470 Serine/threonine-protein kinase PLK1 Homo sapiens 4.7 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565584&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162661537 461685922 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400166 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N2CCCC2)ncc1C InChI=1S/C27H34N6O3S/c1-18-17-28-27(31-25(18)29-22-10-15-37-24(22)26(34)36-3)30-21-7-6-20(16-23(21)35-2)33-13-8-19(9-14-33)32-11-4-5-12-32/h6-7,10,15-17,19H,4-5,8-9,11-14H2,1-3H3,(H2,28,29,30,31) HSDRBLSQJHLCPP-UHFFFAOYSA-N 50565585 CHEMBL4776291 Serine/threonine-protein kinase PLK1 Homo sapiens 2.2 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565585&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643061 461685923 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51400167 COC(=O)c1sccc1Nc1nc(Nc2ccc(cc2OC)N2CCC(CC2)N(C)C)ncc1C InChI=1S/C25H32N6O3S/c1-16-15-26-25(29-23(16)27-20-10-13-35-22(20)24(32)34-5)28-19-7-6-18(14-21(19)33-4)31-11-8-17(9-12-31)30(2)3/h6-7,10,13-15,17H,8-9,11-12H2,1-5H3,(H2,26,27,28,29) CABIJFMAGGMDJK-UHFFFAOYSA-N 50565586 CHEMBL4799529 Serine/threonine-protein kinase PLK1 Homo sapiens 1.9 ChEMBL 10.1016/j.ejmech.2020.112697 10.7270/Q2PK0KWC 32814244 Deng, Z; Chen, G; Liu, S; Li, Y; Zhong, J; Zhang, B; Li, L; Huang, H; Wang, Z; Xu, Q; Deng, X Xiamen University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565586&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162677012 461685924 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419615 CC(C)(O)c1cccc(n1)-n1cc(F)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12 InChI=1S/C24H26FN7O/c1-24(2,33)20-4-3-5-21(29-20)32-15-19(25)18-14-27-23(30-22(18)32)28-16-6-8-17(9-7-16)31-12-10-26-11-13-31/h3-9,14-15,26,33H,10-13H2,1-2H3,(H,27,28,30) QKKHRJGAYBKACP-UHFFFAOYSA-N 50573433 CHEMBL4876452 Serine/threonine-protein kinase PLK1 Homo sapiens 60 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573433&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156275874 471063578 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419616 CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3ccn(-c4cccc(n4)C(C)(C)O)c3n2)cc1 InChI=1S/C27H31N7O2/c1-27(2,36)22-5-4-6-23(31-22)34-16-11-19-17-28-26(32-24(19)34)30-20-9-7-18(8-10-20)25(35)29-21-12-14-33(3)15-13-21/h4-11,16-17,21,36H,12-15H2,1-3H3,(H,29,35)(H,28,30,32) JECZPVPRJJYJME-UHFFFAOYSA-N 50573434 CHEMBL4860891 Serine/threonine-protein kinase PLK1 Homo sapiens 59 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573434&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156283148 471063579 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419617 CC(C)(O)c1cccc(n1)-n1cc(F)c2cnc(Nc3ccc(cc3)N3CCNC4(CC4)C3)nc12 InChI=1S/C26H28FN7O/c1-25(2,35)21-4-3-5-22(31-21)34-15-20(27)19-14-28-24(32-23(19)34)30-17-6-8-18(9-7-17)33-13-12-29-26(16-33)10-11-26/h3-9,14-15,29,35H,10-13,16H2,1-2H3,(H,28,30,32) IHUGVYIBZUCCAS-UHFFFAOYSA-N 50573435 CHEMBL4878853 Serine/threonine-protein kinase PLK1 Homo sapiens 61 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573435&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156283144 471063580 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419618 CC(C)(O)c1cccc(n1)-n1cc(F)c2cnc(Nc3ccc(NC(=O)C4CCOCC4)cc3)nc12 InChI=1S/C26H27FN6O3/c1-26(2,35)21-4-3-5-22(31-21)33-15-20(27)19-14-28-25(32-23(19)33)30-18-8-6-17(7-9-18)29-24(34)16-10-12-36-13-11-16/h3-9,14-16,35H,10-13H2,1-2H3,(H,29,34)(H,28,30,32) QMAVWDJUBQEBDQ-UHFFFAOYSA-N 50573436 CHEMBL4846720 Serine/threonine-protein kinase PLK1 Homo sapiens 30 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573436&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156283149 471063581 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419619 CN1CCN(CC1)c1ccc(Nc2ncc3c(F)cn(-c4cccc(N=S(C)(C)=O)n4)c3n2)cc1 InChI=1S/C24H27FN8OS/c1-31-11-13-32(14-12-31)18-9-7-17(8-10-18)27-24-26-15-19-20(25)16-33(23(19)29-24)22-6-4-5-21(28-22)30-35(2,3)34/h4-10,15-16H,11-14H2,1-3H3,(H,26,27,29) MDUWYOZDVRKSHB-UHFFFAOYSA-N 50573437 CHEMBL4873244 Serine/threonine-protein kinase PLK1 Homo sapiens 384 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573437&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156275966 471063582 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419620 CC(C)(O)c1cccc(n1)-n1cc(F)c2cnc(Nc3ccc(cc3)N3C[C@H]4C[C@@H]3CN4)nc12 InChI=1S/C25H26FN7O/c1-25(2,34)21-4-3-5-22(30-21)33-14-20(26)19-12-28-24(31-23(19)33)29-15-6-8-17(9-7-15)32-13-16-10-18(32)11-27-16/h3-9,12,14,16,18,27,34H,10-11,13H2,1-2H3,(H,28,29,31)/t16-,18-/m1/s1 NMIWWLZKGDETAG-SJLPKXTDSA-N 50573438 CHEMBL4871955 Serine/threonine-protein kinase PLK1 Homo sapiens 19 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573438&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 164622991 471063583 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419621 CC(C)(O)c1cccc(n1)-n1cc(F)c2cnc(Nc3ccc(cc3)N3C[C@@H]4C[C@H]3CN4)nc12 InChI=1S/C25H26FN7O/c1-25(2,34)21-4-3-5-22(30-21)33-14-20(26)19-12-28-24(31-23(19)33)29-15-6-8-17(9-7-15)32-13-16-10-18(32)11-27-16/h3-9,12,14,16,18,27,34H,10-11,13H2,1-2H3,(H,28,29,31)/t16-,18-/m0/s1 NMIWWLZKGDETAG-WMZOPIPTSA-N 50573439 CHEMBL4857055 Serine/threonine-protein kinase PLK1 Homo sapiens 30 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573439&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156282981 471063584 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419622 CCN1CCC(CC1)Oc1ccc(Nc2ncc3c(F)cn(-c4cccc(n4)C(C)(C)O)c3n2)cc1 InChI=1S/C27H31FN6O2/c1-4-33-14-12-20(13-15-33)36-19-10-8-18(9-11-19)30-26-29-16-21-22(28)17-34(25(21)32-26)24-7-5-6-23(31-24)27(2,3)35/h5-11,16-17,20,35H,4,12-15H2,1-3H3,(H,29,30,32) PKEGAIRYQRMJBD-UHFFFAOYSA-N 50573440 CHEMBL4854224 Serine/threonine-protein kinase PLK1 Homo sapiens 39 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573440&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156282976 471063585 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419623 CC(C)(O)c1cccc(n1)-n1cc(F)c2cnc(Nc3ccc(cc3)C(=O)NC3CCOCC3)nc12 InChI=1S/C26H27FN6O3/c1-26(2,35)21-4-3-5-22(31-21)33-15-20(27)19-14-28-25(32-23(19)33)30-17-8-6-16(7-9-17)24(34)29-18-10-12-36-13-11-18/h3-9,14-15,18,35H,10-13H2,1-2H3,(H,29,34)(H,28,30,32) JSOGYNPOXPTXNN-UHFFFAOYSA-N 50573441 CHEMBL4860427 Serine/threonine-protein kinase PLK1 Homo sapiens 9.0 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573441&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156282984 471063586 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419624 CN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3c(F)cn(-c4cccc(n4)C(C)(C)O)c3n2)cc1 InChI=1S/C27H30FN7O2/c1-27(2,37)22-5-4-6-23(32-22)35-16-21(28)20-15-29-26(33-24(20)35)31-18-9-7-17(8-10-18)25(36)30-19-11-13-34(3)14-12-19/h4-10,15-16,19,37H,11-14H2,1-3H3,(H,30,36)(H,29,31,33) ZHZUHNWBNIKEGE-UHFFFAOYSA-N 50573442 CHEMBL4863747 Serine/threonine-protein kinase PLK1 Homo sapiens 29 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573442&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156282979 471063587 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419625 CCN1CCC(CC1)NC(=O)c1ccc(Nc2ncc3c(F)cn(-c4cccc(n4)C(C)(C)O)c3n2)cc1 InChI=1S/C28H32FN7O2/c1-4-35-14-12-20(13-15-35)31-26(37)18-8-10-19(11-9-18)32-27-30-16-21-22(29)17-36(25(21)34-27)24-7-5-6-23(33-24)28(2,3)38/h5-11,16-17,20,38H,4,12-15H2,1-3H3,(H,31,37)(H,30,32,34) LXQFQJQZJHRTKK-UHFFFAOYSA-N 50573443 CHEMBL4864046 Serine/threonine-protein kinase PLK1 Homo sapiens 34 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573443&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156282972 471063588 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51419626 CN1CCN(CC1)c1ccc(Nc2ncc3c(F)cn(-c4cccc(n4)C4(F)COC4)c3n2)cc1 InChI=1S/C25H25F2N7O/c1-32-9-11-33(12-10-32)18-7-5-17(6-8-18)29-24-28-13-19-20(26)14-34(23(19)31-24)22-4-2-3-21(30-22)25(27)15-35-16-25/h2-8,13-14H,9-12,15-16H2,1H3,(H,28,29,31) YWPFNMWBTFTQGS-UHFFFAOYSA-N 50573444 CHEMBL4852679 Serine/threonine-protein kinase PLK1 Homo sapiens 24 ChEMBL 10.1021/acsmedchemlett.1c00442 10.7270/Q2ZK5MFB 34676025 Kargbo, RB Usona Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573444&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156276049 471063589 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51433761 CCC1(O)CCc2ccc(nc12)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc12 InChI=1S/C29H34N8O2/c1-4-14-36-27(38)23-19-30-28(31-21-7-9-22(10-8-21)35-17-15-34(3)16-18-35)33-26(23)37(36)24-11-6-20-12-13-29(39,5-2)25(20)32-24/h4,6-11,19,39H,1,5,12-18H2,2-3H3,(H,30,31,33) OXTSYWDBUVRXFF-UHFFFAOYSA-N 50579217 CHEMBL4871593 Serine/threonine-protein kinase PLK1 Homo sapiens 227 ChEMBL 10.1021/acs.jmedchem.1c01121 10.7270/Q2JW8JQM 34423975 Huang, PQ; Boren, BC; Hegde, SG; Liu, H; Unni, AK; Abraham, S; Hopkins, CD; Paliwal, S; Samatar, AA; Li, J; Bunker, KD Zentalis Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50579217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50579217&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 05J 7N3U 139467637 471055340 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446542 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CCCN1)[C@@H](C)OP(O)(O)=O InChI=1S/C34H59N8O14PS/c1-18(2)16-23(34(51)55-4)39-32(49)25-9-7-14-42(25)33(50)27(19(3)56-57(52,53)54)41-31(48)24(17-43)40-29(46)21(10-11-26(35)44)37-30(47)22(12-15-58-5)38-28(45)20-8-6-13-36-20/h18-25,27,36,43H,6-17H2,1-5H3,(H2,35,44)(H,37,47)(H,38,45)(H,39,49)(H,40,46)(H,41,48)(H2,52,53,54)/t19-,20+,21+,22+,23+,24+,25+,27+/m1/s1 BOSAPELIHBBTDT-WOWOAPDMSA-N 50584421 CHEMBL5075583 Serine/threonine-protein kinase PLK1 Homo sapiens 6270 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584421&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166626524 476020508 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446543 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)c1cccc(c1)C(F)(F)F)[C@@H](C)OP(O)(O)=O InChI=1S/C32H46F3N6O13P/c1-16(2)13-21(31(49)53-4)38-29(47)23-9-6-12-41(23)30(48)25(17(3)54-55(50,51)52)40-28(46)22(15-42)39-27(45)20(10-11-24(36)43)37-26(44)18-7-5-8-19(14-18)32(33,34)35/h5,7-8,14,16-17,20-23,25,42H,6,9-13,15H2,1-4H3,(H2,36,43)(H,37,44)(H,38,47)(H,39,45)(H,40,46)(H2,50,51,52)/t17-,20+,21+,22+,23+,25+/m1/s1 ZAPVUMHJMSWHNG-PFQZNFRVSA-N 50584422 CHEMBL5082708 Serine/threonine-protein kinase PLK1 Homo sapiens 17630 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584422&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166628457 476020509 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446544 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 IYLBMSHZRRWSRM-FALOATQWSA-N 50426931 CHEMBL2323729 Serine/threonine-protein kinase PLK1 Homo sapiens 36790 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42608451 164155806 CHEMBL2323729 ZINC95584623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446545 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@@H]3CCCN3)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C36H61N8O15PS/c1-19(2)17-24(36(53)57-4)41-34(51)26-9-11-28-44(26)35(52)29(20(3)59-60(54,55)56)43-33(50)25(18-45)42-31(48)22(8-10-27(46)38-14-15-58-28)39-32(49)23(12-16-61-5)40-30(47)21-7-6-13-37-21/h19-26,28-29,37,45H,6-18H2,1-5H3,(H,38,46)(H,39,49)(H,40,47)(H,41,51)(H,42,48)(H,43,50)(H2,54,55,56)/t20-,21+,22+,23+,24+,25+,26+,28-,29+/m1/s1 RVTPNHGTTLWXPG-JNPKWWJQSA-N 50584423 CHEMBL5083550 Serine/threonine-protein kinase PLK1 Homo sapiens 680 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584423&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166627501 476020510 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446546 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)c3cccc(c3)C(F)(F)F)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C34H48F3N6O14P/c1-17(2)14-22(33(51)55-4)40-31(49)24-9-11-26-43(24)32(50)27(18(3)57-58(52,53)54)42-30(48)23(16-44)41-29(47)21(8-10-25(45)38-12-13-56-26)39-28(46)19-6-5-7-20(15-19)34(35,36)37/h5-7,15,17-18,21-24,26-27,44H,8-14,16H2,1-4H3,(H,38,45)(H,39,46)(H,40,49)(H,41,47)(H,42,48)(H2,52,53,54)/t18-,21+,22+,23+,24+,26-,27+/m1/s1 AQVFEOGYDIPWJH-WVBPCUAESA-N 50584424 CHEMBL5089196 Serine/threonine-protein kinase PLK1 Homo sapiens 2220 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584424&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166633638 476020511 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446547 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)c3cccc(OCCN(C)C)c3)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C37H58N7O15P/c1-21(2)18-26(37(52)56-6)40-35(50)28-11-13-30-44(28)36(51)31(22(3)59-60(53,54)55)42-34(49)27(20-45)41-33(48)25(10-12-29(46)38-14-16-58-30)39-32(47)23-8-7-9-24(19-23)57-17-15-43(4)5/h7-9,19,21-22,25-28,30-31,45H,10-18,20H2,1-6H3,(H,38,46)(H,39,47)(H,40,50)(H,41,48)(H,42,49)(H2,53,54,55)/t22-,25+,26+,27+,28+,30-,31+/m1/s1 CUZJQWWMSFSQQO-PIWOXJGESA-N 50584425 CHEMBL5081088 Serine/threonine-protein kinase PLK1 Homo sapiens 1920 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584425&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166628573 476020512 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446548 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)c3cccc(OCC(C)C)c3)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C37H57N6O15P/c1-20(2)16-26(37(51)55-6)40-35(49)28-11-13-30-43(28)36(50)31(22(5)58-59(52,53)54)42-34(48)27(18-44)41-33(47)25(10-12-29(45)38-14-15-56-30)39-32(46)23-8-7-9-24(17-23)57-19-21(3)4/h7-9,17,20-22,25-28,30-31,44H,10-16,18-19H2,1-6H3,(H,38,45)(H,39,46)(H,40,49)(H,41,47)(H,42,48)(H2,52,53,54)/t22-,25+,26+,27+,28+,30-,31+/m1/s1 BNAIEYIOWDLSDG-PIWOXJGESA-N 50584426 CHEMBL5089536 Serine/threonine-protein kinase PLK1 Homo sapiens 640 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584426&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166636406 476020513 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446549 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)c3cc(OCCN(C)C)cc(OCC(C)C)c3)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C41H66N7O16P/c1-23(2)17-30(41(56)60-8)44-39(54)32-10-12-34-48(32)40(55)35(25(5)64-65(57,58)59)46-38(53)31(21-49)45-37(52)29(9-11-33(50)42-13-15-62-34)43-36(51)26-18-27(61-16-14-47(6)7)20-28(19-26)63-22-24(3)4/h18-20,23-25,29-32,34-35,49H,9-17,21-22H2,1-8H3,(H,42,50)(H,43,51)(H,44,54)(H,45,52)(H,46,53)(H2,57,58,59)/t25-,29+,30+,31+,32+,34-,35+/m1/s1 KMQLGBANVZOQDR-QPAFJHMNSA-N 50584427 CHEMBL5083531 Serine/threonine-protein kinase PLK1 Homo sapiens 500 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584427&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166627492 476020514 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446550 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)c3cc(OCC(C)C)cc(OCC(C)C)c3)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C41H65N6O16P/c1-22(2)15-30(41(55)59-8)44-39(53)32-10-12-34-47(32)40(54)35(25(7)63-64(56,57)58)46-38(52)31(19-48)45-37(51)29(9-11-33(49)42-13-14-60-34)43-36(50)26-16-27(61-20-23(3)4)18-28(17-26)62-21-24(5)6/h16-18,22-25,29-32,34-35,48H,9-15,19-21H2,1-8H3,(H,42,49)(H,43,50)(H,44,53)(H,45,51)(H,46,52)(H2,56,57,58)/t25-,29+,30+,31+,32+,34-,35+/m1/s1 CUHDKQFMGBYHBI-QPAFJHMNSA-N 50584428 CHEMBL5082952 Serine/threonine-protein kinase PLK1 Homo sapiens 200 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584428&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166629600 476020515 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446551 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)c3cc(OCCCC(O)=O)cc(OCCN(C)C)c3)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C41H64N7O18P/c1-23(2)18-29(41(58)62-6)44-39(56)31-10-12-33-48(31)40(57)35(24(3)66-67(59,60)61)46-38(55)30(22-49)45-37(54)28(9-11-32(50)42-13-16-65-33)43-36(53)25-19-26(63-15-7-8-34(51)52)21-27(20-25)64-17-14-47(4)5/h19-21,23-24,28-31,33,35,49H,7-18,22H2,1-6H3,(H,42,50)(H,43,53)(H,44,56)(H,45,54)(H,46,55)(H,51,52)(H2,59,60,61)/t24-,28+,29+,30+,31+,33-,35+/m1/s1 ADASRLGYHVXZRO-DKLZTFJRSA-N 50584429 CHEMBL5075075 Serine/threonine-protein kinase PLK1 Homo sapiens 1650 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584429&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166627182 476020516 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446552 COC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CC[C@H]2OCCNC(=O)CC[C@H](NC(=O)c3cc(OCCN(C)C)cc(c3)-c3ccc(cc3)C(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(=O)N12 InChI=1S/C44H62N7O17P/c1-24(2)19-32(44(61)65-6)47-41(57)34-12-14-36-51(34)42(58)37(25(3)68-69(62,63)64)49-40(56)33(23-52)48-39(55)31(11-13-35(53)45-15-17-67-36)46-38(54)29-20-28(21-30(22-29)66-18-16-50(4)5)26-7-9-27(10-8-26)43(59)60/h7-10,20-22,24-25,31-34,36-37,52H,11-19,23H2,1-6H3,(H,45,53)(H,46,54)(H,47,57)(H,48,55)(H,49,56)(H,59,60)(H2,62,63,64)/t25-,31+,32+,33+,34+,36-,37+/m1/s1 YSWRUCSWHFLYKP-YBHQZPAMSA-N 50584430 CHEMBL5093970 Serine/threonine-protein kinase PLK1 Homo sapiens 1230 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584430&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166633807 476020517 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51446553 COCCOCCOCCOCCOc1cc(OCCOCCOCCOCCOC)cc(c1)C(=O)N[C@H]1CCC(=O)NCCO[C@@H]2CC[C@H](N2C(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)OC InChI=1S/C51H85N6O24P/c1-34(2)29-40(51(65)71-6)54-49(63)42-8-10-44-57(42)50(64)45(35(3)81-82(66,67)68)56-48(62)41(33-58)55-47(61)39(7-9-43(59)52-11-12-80-44)53-46(60)36-30-37(78-27-25-76-23-21-74-19-17-72-15-13-69-4)32-38(31-36)79-28-26-77-24-22-75-20-18-73-16-14-70-5/h30-32,34-35,39-42,44-45,58H,7-29,33H2,1-6H3,(H,52,59)(H,53,60)(H,54,63)(H,55,61)(H,56,62)(H2,66,67,68)/t35-,39+,40+,41+,42+,44-,45+/m1/s1 OJWIHLCNBBCVPZ-GDRREVSNSA-N 50584431 CHEMBL5078060 Serine/threonine-protein kinase PLK1 Homo sapiens 830 ChEMBL 10.1021/acs.jmedchem.1c01359 10.7270/Q2474FSG 35029981 Ryu, S; Park, JE; Ham, YJ; Lim, DC; Kwiatkowski, NP; Kim, DH; Bhunia, D; Kim, ND; Yaffe, MB; Son, W; Kim, N; Choi, TI; Swain, P; Kim, CH; Lee, JY; Gray, NS; Lee, KS; Sim, T Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584431&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166628697 476020518 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51453556 CC[C@H]1N(C2CCCC2)c2nc(ncc2N(C)C1=O)N(C)c1ccc(cc1OC)-c1nc2c(cccc2[nH]1)C(N)=O 50586865 CHEMBL5084388 Serine/threonine-protein kinase PLK1 Homo sapiens 2028 ChEMBL 10.1021/acs.jmedchem.1c01535 10.7270/Q22N566V 34813314 Wang, SP; Li, Y; Huang, SH; Wu, SQ; Gao, LL; Sun, Q; Lin, QW; Huang, L; Meng, LQ; Zou, Y; Zhu, QH; Xu, YG China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50586865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50586865&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166633451 476022952 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440721 CCCCCCc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C20H23NO3/c1-2-3-4-5-8-15-11-13-16(14-12-15)19(22)21-18-10-7-6-9-17(18)20(23)24/h6-7,9-14H,2-5,8H2,1H3,(H,21,22)(H,23,24) FKAZACXXFMQQFZ-UHFFFAOYSA-N 50581994 CHEMBL5087960 Serine/threonine-protein kinase PLK1 Homo sapiens 60900 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581994&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4105136 476026999 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440722 CCCCCCCNc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C21H26N2O3/c1-2-3-4-5-8-15-22-17-13-11-16(12-14-17)20(24)23-19-10-7-6-9-18(19)21(25)26/h6-7,9-14,22H,2-5,8,15H2,1H3,(H,23,24)(H,25,26) WJERRUOGLWEBPY-UHFFFAOYSA-N 50581995 CHEMBL5090673 Serine/threonine-protein kinase PLK1 Homo sapiens 87400 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581995&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 132389759 476027000 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440723 CCCCCCCOc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C21H25NO4/c1-2-3-4-5-8-15-26-17-13-11-16(12-14-17)20(23)22-19-10-7-6-9-18(19)21(24)25/h6-7,9-14H,2-5,8,15H2,1H3,(H,22,23)(H,24,25) OKIXYUNGPOSZNJ-UHFFFAOYSA-N 50581996 CHEMBL5088590 Serine/threonine-protein kinase PLK1 Homo sapiens 37000 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581996&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54855910 476027001 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440724 CCCCCCCSc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C21H25NO3S/c1-2-3-4-5-8-15-26-17-13-11-16(12-14-17)20(23)22-19-10-7-6-9-18(19)21(24)25/h6-7,9-14H,2-5,8,15H2,1H3,(H,22,23)(H,24,25) RRSAIDJTFVHSDP-UHFFFAOYSA-N 50581997 CHEMBL5087226 Serine/threonine-protein kinase PLK1 Homo sapiens 29000 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581997&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166634263 476027002 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440725 CCCCCCCNc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C22H28N2O3/c1-3-4-5-6-7-14-23-18-11-9-17(10-12-18)21(25)24-20-13-8-16(2)15-19(20)22(26)27/h8-13,15,23H,3-7,14H2,1-2H3,(H,24,25)(H,26,27) MPYOENGSGIMZBH-UHFFFAOYSA-N 50581998 CHEMBL5088002 Serine/threonine-protein kinase PLK1 Homo sapiens 42050 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581998&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166633967 476027003 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440726 CCCCCCCOc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C22H27NO4/c1-3-4-5-6-7-14-27-18-11-9-17(10-12-18)21(24)23-20-13-8-16(2)15-19(20)22(25)26/h8-13,15H,3-7,14H2,1-2H3,(H,23,24)(H,25,26) QQHBQSOTACDLMA-UHFFFAOYSA-N 50581999 CHEMBL5078316 Serine/threonine-protein kinase PLK1 Homo sapiens 34400 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581999&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166628018 476027004 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440727 CCCCCCCSc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C22H27NO3S/c1-3-4-5-6-7-14-27-18-11-9-17(10-12-18)21(24)23-20-13-8-16(2)15-19(20)22(25)26/h8-13,15H,3-7,14H2,1-2H3,(H,23,24)(H,25,26) CAEIDMRGRUBZPP-UHFFFAOYSA-N 50582000 CHEMBL5091858 Serine/threonine-protein kinase PLK1 Homo sapiens 23400 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582000&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166633740 476027005 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440728 CCCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C24H31NO3/c1-3-4-5-6-7-8-9-10-19-12-14-20(15-13-19)23(26)25-22-16-11-18(2)17-21(22)24(27)28/h11-17H,3-10H2,1-2H3,(H,25,26)(H,27,28) QNCVWIUWUIVEDY-UHFFFAOYSA-N 50582001 CHEMBL5093376 Serine/threonine-protein kinase PLK1 Homo sapiens 33800 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582001&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166634763 476027006 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440729 CCCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(=O)OC InChI=1S/C25H33NO3/c1-4-5-6-7-8-9-10-11-20-13-15-21(16-14-20)24(27)26-23-17-12-19(2)18-22(23)25(28)29-3/h12-18H,4-11H2,1-3H3,(H,26,27) IYEAWSUQCSTUEC-UHFFFAOYSA-N 50582002 CHEMBL5082111 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582002&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166628609 476027007 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440730 CCCCCCCCNc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C23H30N2O3/c1-3-4-5-6-7-8-15-24-19-12-10-18(11-13-19)22(26)25-21-14-9-17(2)16-20(21)23(27)28/h9-14,16,24H,3-8,15H2,1-2H3,(H,25,26)(H,27,28) PRLUIFNNEDXWLF-UHFFFAOYSA-N 50582003 CHEMBL5075419 Serine/threonine-protein kinase PLK1 Homo sapiens 73200 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582003&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166626215 476027008 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440731 CCCCCCCCOc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C23H29NO4/c1-3-4-5-6-7-8-15-28-19-12-10-18(11-13-19)22(25)24-21-14-9-17(2)16-20(21)23(26)27/h9-14,16H,3-8,15H2,1-2H3,(H,24,25)(H,26,27) IJJAHVXKDUSDSU-UHFFFAOYSA-N 50582004 CHEMBL5078341 Serine/threonine-protein kinase PLK1 Homo sapiens 28600 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582004&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166628700 476027009 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440732 CCCCCCCCSc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C23H29NO3S/c1-3-4-5-6-7-8-15-28-19-12-10-18(11-13-19)22(25)24-21-14-9-17(2)16-20(21)23(26)27/h9-14,16H,3-8,15H2,1-2H3,(H,24,25)(H,26,27) AFZUGVIEBVWBSZ-UHFFFAOYSA-N 50582005 CHEMBL5093856 Serine/threonine-protein kinase PLK1 Homo sapiens 26800 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582005&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 164946933 476027010 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440733 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(cc1C(O)=O)C(F)(F)F InChI=1S/C23H26F3NO3/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)21(28)27-20-14-13-18(23(24,25)26)15-19(20)22(29)30/h9-15H,2-8H2,1H3,(H,27,28)(H,29,30) WJIGDVAAXLTOOC-UHFFFAOYSA-N 50582006 CHEMBL5090294 Serine/threonine-protein kinase PLK1 Homo sapiens 23500 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582006&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166632998 476027011 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440734 CCCCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C25H33NO3/c1-3-4-5-6-7-8-9-10-11-20-13-15-21(16-14-20)24(27)26-23-17-12-19(2)18-22(23)25(28)29/h12-18H,3-11H2,1-2H3,(H,26,27)(H,28,29) KOSFVUBMFCHWJW-UHFFFAOYSA-N 50582007 CHEMBL5076085 Serine/threonine-protein kinase PLK1 Homo sapiens 23800 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582007&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166627099 476027012 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440735 CCCCCCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C27H37NO3/c1-3-4-5-6-7-8-9-10-11-12-13-22-15-17-23(18-16-22)26(29)28-25-19-14-21(2)20-24(25)27(30)31/h14-20H,3-13H2,1-2H3,(H,28,29)(H,30,31) HZRMBZXUYFWINN-UHFFFAOYSA-N 50582008 CHEMBL5072672 Serine/threonine-protein kinase PLK1 Homo sapiens 26100 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582008&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166630785 476027013 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440736 CCCCCCCCCc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(O)=O InChI=1S/C24H31NO3/c1-3-4-5-6-7-8-9-10-19-12-14-20(15-13-19)23(26)25-22-17-18(2)11-16-21(22)24(27)28/h11-17H,3-10H2,1-2H3,(H,25,26)(H,27,28) OATFEKULCCLGSW-UHFFFAOYSA-N 50582009 CHEMBL5070506 Serine/threonine-protein kinase PLK1 Homo sapiens 28000 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582009&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166625315 476027014 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440737 CCCCCCCCCc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(=O)OC InChI=1S/C25H33NO3/c1-4-5-6-7-8-9-10-11-20-13-15-21(16-14-20)24(27)26-23-18-19(2)12-17-22(23)25(28)29-3/h12-18H,4-11H2,1-3H3,(H,26,27) DLFPSPHUZCKONZ-UHFFFAOYSA-N 50582010 CHEMBL5079058 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582010&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166629229 476027015 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440738 CCCCCCCCCCCCc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(O)=O InChI=1S/C27H37NO3/c1-3-4-5-6-7-8-9-10-11-12-13-22-15-17-23(18-16-22)26(29)28-25-20-21(2)14-19-24(25)27(30)31/h14-20H,3-13H2,1-2H3,(H,28,29)(H,30,31) UXPZRFNMCJXZNY-UHFFFAOYSA-N 50582011 CHEMBL5084511 Serine/threonine-protein kinase PLK1 Homo sapiens 25500 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582011&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166636242 476027016 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440739 CCCCCCCCNc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(O)=O InChI=1S/C23H30N2O3/c1-3-4-5-6-7-8-15-24-19-12-10-18(11-13-19)22(26)25-21-16-17(2)9-14-20(21)23(27)28/h9-14,16,24H,3-8,15H2,1-2H3,(H,25,26)(H,27,28) PGHIUKRDLBEISD-UHFFFAOYSA-N 50582012 CHEMBL5089587 Serine/threonine-protein kinase PLK1 Homo sapiens 27100 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582012&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166632352 476027017 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440740 CCCCCCCCOc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(O)=O InChI=1S/C23H29NO4/c1-3-4-5-6-7-8-15-28-19-12-10-18(11-13-19)22(25)24-21-16-17(2)9-14-20(21)23(26)27/h9-14,16H,3-8,15H2,1-2H3,(H,24,25)(H,26,27) LNPROZPNVIRTCQ-UHFFFAOYSA-N 50582013 CHEMBL5089264 Serine/threonine-protein kinase PLK1 Homo sapiens 29800 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582013&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166635371 476027018 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440741 CCCCCCCCSc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(O)=O InChI=1S/C23H29NO3S/c1-3-4-5-6-7-8-15-28-19-12-10-18(11-13-19)22(25)24-21-16-17(2)9-14-20(21)23(26)27/h9-14,16H,3-8,15H2,1-2H3,(H,24,25)(H,26,27) BUPKKYJLEQAZDG-UHFFFAOYSA-N 50582014 CHEMBL5076395 Serine/threonine-protein kinase PLK1 Homo sapiens 28100 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582014&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166626912 476027019 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440742 Cc1ccc(C(O)=O)c(NC(=O)c2ccc(N)cc2)c1 InChI=1S/C15H14N2O3/c1-9-2-7-12(15(19)20)13(8-9)17-14(18)10-3-5-11(16)6-4-10/h2-8H,16H2,1H3,(H,17,18)(H,19,20) WMVZLQXSATXASC-UHFFFAOYSA-N 50582015 CHEMBL5092462 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582015&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 166633375 476027020 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51440743 CCCCCCCCSc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C23H29NO3S/c1-3-4-5-6-7-8-15-28-19-12-10-18(11-13-19)22(25)24-21-14-9-17(2)16-20(21)23(26)27/h9-14,16H,3-8,15H2,1-2H3,(H,24,25)(H,26,27) AFZUGVIEBVWBSZ-UHFFFAOYSA-N 50582005 CHEMBL5093856 Serine/threonine-protein kinase PLK1 Homo sapiens 650 ChEMBL 10.1021/acs.jmedchem.1c00133 10.7270/Q2TH8RK0 34210138 Chapagai, D; Ramamoorthy, G; Varghese, J; Nurmemmedov, E; McInnes, C; Wyatt, MD University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50582005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50582005&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 164946933 476027010 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487425 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C48H59N11O7/c1-4-35-43-55-54-29(2)58(43)37-27-49-48(53-42(37)57(35)28-30-12-7-5-8-13-30)51-34-17-16-31(26-39(34)65-3)44(61)50-32-20-23-56(24-21-32)22-9-6-10-25-66-38-15-11-14-33-41(38)47(64)59(46(33)63)36-18-19-40(60)52-45(36)62/h11,14-17,26-27,30,32,35-36H,4-10,12-13,18-25,28H2,1-3H3,(H,50,61)(H,49,51,53)(H,52,60,62)/t35-,36?/m1/s1 ZHYQBWGBTQAYNU-RERZGLEZSA-N 50599447 CHEMBL5205649 Serine/threonine-protein kinase PLK1 Homo sapiens 1116 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599447&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168296210 482610299 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487426 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C49H61N11O7/c1-4-36-44-56-55-30(2)59(44)38-28-50-49(54-43(38)58(36)29-31-13-8-7-9-14-31)52-35-18-17-32(27-40(35)66-3)45(62)51-33-21-24-57(25-22-33)23-10-5-6-11-26-67-39-16-12-15-34-42(39)48(65)60(47(34)64)37-19-20-41(61)53-46(37)63/h12,15-18,27-28,31,33,36-37H,4-11,13-14,19-26,29H2,1-3H3,(H,51,62)(H,50,52,54)(H,53,61,63)/t36-,37?/m1/s1 RRIFTIGEWSMNLK-RKROREJRSA-N 50599448 CHEMBL5183053 Serine/threonine-protein kinase PLK1 Homo sapiens 2431 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599448&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168278464 482610300 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487427 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C50H63N11O7/c1-4-37-45-57-56-31(2)60(45)39-29-51-50(55-44(39)59(37)30-32-14-9-8-10-15-32)53-36-19-18-33(28-41(36)67-3)46(63)52-34-22-25-58(26-23-34)24-11-6-5-7-12-27-68-40-17-13-16-35-43(40)49(66)61(48(35)65)38-20-21-42(62)54-47(38)64/h13,16-19,28-29,32,34,37-38H,4-12,14-15,20-27,30H2,1-3H3,(H,52,63)(H,51,53,55)(H,54,62,64)/t37-,38?/m1/s1 WMCQTFNRVRZVSG-MLPLAHBKSA-N 50599449 CHEMBL5181704 Serine/threonine-protein kinase PLK1 Homo sapiens 1252 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599449&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168277535 482610301 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487428 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C51H65N11O7/c1-4-38-46-58-57-32(2)61(46)40-30-52-51(56-45(40)60(38)31-33-15-10-9-11-16-33)54-37-20-19-34(29-42(37)68-3)47(64)53-35-23-26-59(27-24-35)25-12-7-5-6-8-13-28-69-41-18-14-17-36-44(41)50(67)62(49(36)66)39-21-22-43(63)55-48(39)65/h14,17-20,29-30,33,35,38-39H,4-13,15-16,21-28,31H2,1-3H3,(H,53,64)(H,52,54,56)(H,55,63,65)/t38-,39?/m1/s1 VLUDNLDRTOYHAK-SWGHGFEUSA-N 50599450 CHEMBL5184597 Serine/threonine-protein kinase PLK1 Homo sapiens 5139 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599450&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168279880 482610302 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487429 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCCCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C52H67N11O7/c1-4-39-47-59-58-33(2)62(47)41-31-53-52(57-46(41)61(39)32-34-16-11-10-12-17-34)55-38-21-20-35(30-43(38)69-3)48(65)54-36-24-27-60(28-25-36)26-13-8-6-5-7-9-14-29-70-42-19-15-18-37-45(42)51(68)63(50(37)67)40-22-23-44(64)56-49(40)66/h15,18-21,30-31,34,36,39-40H,4-14,16-17,22-29,32H2,1-3H3,(H,54,65)(H,53,55,57)(H,56,64,66)/t39-,40?/m1/s1 CMQKEDHPTQZDSM-IPVUVHESSA-N 50599451 CHEMBL5172038 Serine/threonine-protein kinase PLK1 Homo sapiens 2127 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599451&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168270672 482610303 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487430 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCCCCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C53H69N11O7/c1-4-40-48-60-59-34(2)63(48)42-32-54-53(58-47(42)62(40)33-35-17-12-11-13-18-35)56-39-22-21-36(31-44(39)70-3)49(66)55-37-25-28-61(29-26-37)27-14-9-7-5-6-8-10-15-30-71-43-20-16-19-38-46(43)52(69)64(51(38)68)41-23-24-45(65)57-50(41)67/h16,19-22,31-32,35,37,40-41H,4-15,17-18,23-30,33H2,1-3H3,(H,55,66)(H,54,56,58)(H,57,65,67)/t40-,41?/m1/s1 ZCDWJQMEWFYKEZ-AXHXVYJZSA-N 50599452 CHEMBL5175090 Serine/threonine-protein kinase PLK1 Homo sapiens 5575 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599452&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168276492 482610304 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487431 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCCCCCCCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C54H71N11O7/c1-4-41-49-61-60-35(2)64(49)43-33-55-54(59-48(43)63(41)34-36-18-13-12-14-19-36)57-40-23-22-37(32-45(40)71-3)50(67)56-38-26-29-62(30-27-38)28-15-10-8-6-5-7-9-11-16-31-72-44-21-17-20-39-47(44)53(70)65(52(39)69)42-24-25-46(66)58-51(42)68/h17,20-23,32-33,36,38,41-42H,4-16,18-19,24-31,34H2,1-3H3,(H,56,67)(H,55,57,59)(H,58,66,68)/t41-,42?/m1/s1 FLCJPIAJDUZOIY-HRCVVWNVSA-N 50599453 CHEMBL5197217 Serine/threonine-protein kinase PLK1 Homo sapiens 3817 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599453&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168288948 482610305 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487432 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CCCCNC(=O)COc4cccc5C(=O)C(C6CCC(=O)NC6=O)C(=O)c45)CC3)ncc2-n2c(C)nnc12 InChI=1S/C50H61N11O8/c1-4-36-47-58-57-29(2)61(47)37-26-52-50(56-46(37)60(36)27-30-11-6-5-7-12-30)54-35-17-15-31(25-39(35)68-3)48(66)53-32-19-23-59(24-20-32)22-9-8-21-51-41(63)28-69-38-14-10-13-33-42(38)45(65)43(44(33)64)34-16-18-40(62)55-49(34)67/h10,13-15,17,25-26,30,32,34,36,43H,4-9,11-12,16,18-24,27-28H2,1-3H3,(H,51,63)(H,53,66)(H,52,54,56)(H,55,62,67)/t34?,36-,43?/m1/s1 HWCCWYQDFQTRHY-ZKGBFYIRSA-N 50599454 CHEMBL5183703 Serine/threonine-protein kinase PLK1 Homo sapiens 310 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599454&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168278486 482610306 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487433 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)COc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2-n2c(C)nnc12 InChI=1S/C45H51N11O8/c1-4-31-40-52-51-25(2)55(40)33-22-46-45(50-39(33)54(31)23-26-9-6-5-7-10-26)48-30-14-13-27(21-35(30)63-3)41(59)47-28-17-19-53(20-18-28)37(58)24-64-34-12-8-11-29-38(34)44(62)56(43(29)61)32-15-16-36(57)49-42(32)60/h8,11-14,21-22,26,28,31-32H,4-7,9-10,15-20,23-24H2,1-3H3,(H,47,59)(H,46,48,50)(H,49,57,60)/t31-,32?/m1/s1 AORZPRLVKUMTOJ-XGDNGBMYSA-N 50599455 CHEMBL5177555 Serine/threonine-protein kinase PLK1 Homo sapiens 985 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599455&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 165368932 482610307 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487434 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CCCOc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2-n2c(C)nnc12 InChI=1S/C47H55N11O8/c1-4-33-42-54-53-27(2)57(42)35-25-48-47(52-41(35)56(33)26-28-10-6-5-7-11-28)50-32-16-15-29(24-37(32)65-3)43(61)49-30-19-21-55(22-20-30)39(60)14-9-23-66-36-13-8-12-31-40(36)46(64)58(45(31)63)34-17-18-38(59)51-44(34)62/h8,12-13,15-16,24-25,28,30,33-34H,4-7,9-11,14,17-23,26H2,1-3H3,(H,49,61)(H,48,50,52)(H,51,59,62)/t33-,34?/m1/s1 GBOOMURPCSMHOP-BONSOQDYSA-N 50599456 CHEMBL5196738 Serine/threonine-protein kinase PLK1 Homo sapiens 788 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599456&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168285547 482610308 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487435 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CCCCOc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2-n2c(C)nnc12 InChI=1S/C48H57N11O8/c1-4-34-43-55-54-28(2)58(43)36-26-49-48(53-42(36)57(34)27-29-11-6-5-7-12-29)51-33-17-16-30(25-38(33)66-3)44(62)50-31-20-22-56(23-21-31)40(61)15-8-9-24-67-37-14-10-13-32-41(37)47(65)59(46(32)64)35-18-19-39(60)52-45(35)63/h10,13-14,16-17,25-26,29,31,34-35H,4-9,11-12,15,18-24,27H2,1-3H3,(H,50,62)(H,49,51,53)(H,52,60,63)/t34-,35?/m1/s1 RXBBVTLHCZOFSY-IFDNYZKCSA-N 50599457 CHEMBL5191213 Serine/threonine-protein kinase PLK1 Homo sapiens 1192 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599457&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168286902 482610309 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487436 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CCCCCOc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2-n2c(C)nnc12 InChI=1S/C49H59N11O8/c1-4-35-44-56-55-29(2)59(44)37-27-50-49(54-43(37)58(35)28-30-12-7-5-8-13-30)52-34-18-17-31(26-39(34)67-3)45(63)51-32-21-23-57(24-22-32)41(62)16-9-6-10-25-68-38-15-11-14-33-42(38)48(66)60(47(33)65)36-19-20-40(61)53-46(36)64/h11,14-15,17-18,26-27,30,32,35-36H,4-10,12-13,16,19-25,28H2,1-3H3,(H,51,63)(H,50,52,54)(H,53,61,64)/t35-,36?/m1/s1 VLWJPCFAVATLSZ-RERZGLEZSA-N 50599458 CHEMBL5186301 Serine/threonine-protein kinase PLK1 Homo sapiens 1233 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599458&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168279237 482610310 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487437 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CCCCCCOc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)ncc2-n2c(C)nnc12 InChI=1S/C50H61N11O8/c1-4-36-45-57-56-30(2)60(45)38-28-51-50(55-44(38)59(36)29-31-13-8-7-9-14-31)53-35-19-18-32(27-40(35)68-3)46(64)52-33-22-24-58(25-23-33)42(63)17-10-5-6-11-26-69-39-16-12-15-34-43(39)49(67)61(48(34)66)37-20-21-41(62)54-47(37)65/h12,15-16,18-19,27-28,31,33,36-37H,4-11,13-14,17,20-26,29H2,1-3H3,(H,52,64)(H,51,53,55)(H,54,62,65)/t36-,37?/m1/s1 MJKCEEDXZGWAIW-RKROREJRSA-N 50599459 CHEMBL5188447 Serine/threonine-protein kinase PLK1 Homo sapiens 1840 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599459&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168281499 482610311 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487438 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CNc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)ncc2-n2c(C)nnc12 InChI=1S/C45H54N12O6/c1-4-34-41-53-52-26(2)57(41)36-22-47-45(51-40(36)55(34)24-27-9-6-5-7-10-27)49-33-14-13-28(21-37(33)63-3)42(60)48-29-17-19-54(20-18-29)39(59)23-46-32-12-8-11-30-31(32)25-56(44(30)62)35-15-16-38(58)50-43(35)61/h8,11-14,21-22,27,29,34-35,46H,4-7,9-10,15-20,23-25H2,1-3H3,(H,48,60)(H,47,49,51)(H,50,58,61)/t34-,35?/m1/s1 AXAUUAVSPYBRSD-IFDNYZKCSA-N 50599460 CHEMBL5173126 Serine/threonine-protein kinase PLK1 Homo sapiens 1983 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599460&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168275241 482610312 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487439 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CCCCNc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)ncc2-n2c(C)nnc12 InChI=1S/C48H60N12O6/c1-4-37-44-56-55-29(2)60(44)39-26-50-48(54-43(39)58(37)27-30-11-6-5-7-12-30)52-36-17-16-31(25-40(36)66-3)45(63)51-32-20-23-57(24-21-32)42(62)15-8-9-22-49-35-14-10-13-33-34(35)28-59(47(33)65)38-18-19-41(61)53-46(38)64/h10,13-14,16-17,25-26,30,32,37-38,49H,4-9,11-12,15,18-24,27-28H2,1-3H3,(H,51,63)(H,50,52,54)(H,53,61,64)/t37-,38?/m1/s1 JESXHWUBMBVYMW-MLPLAHBKSA-N 50599461 CHEMBL5204050 Serine/threonine-protein kinase PLK1 Homo sapiens 1337 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599461&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168293801 482610313 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487440 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CCCCCNc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)ncc2-n2c(C)nnc12 InChI=1S/C49H62N12O6/c1-4-38-45-57-56-30(2)61(45)40-27-51-49(55-44(40)59(38)28-31-12-7-5-8-13-31)53-37-18-17-32(26-41(37)67-3)46(64)52-33-21-24-58(25-22-33)43(63)16-9-6-10-23-50-36-15-11-14-34-35(36)29-60(48(34)66)39-19-20-42(62)54-47(39)65/h11,14-15,17-18,26-27,31,33,38-39,50H,4-10,12-13,16,19-25,28-29H2,1-3H3,(H,52,64)(H,51,53,55)(H,54,62,65)/t38-,39?/m1/s1 BXEHPWUOZLISND-SWGHGFEUSA-N 50599462 CHEMBL5184076 Serine/threonine-protein kinase PLK1 Homo sapiens 1212 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599462&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168280571 482610314 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487441 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(CC3)C(=O)CCCCCCC(=O)Nc3cccc4C(=O)N(Cc34)C3CCC(=O)NC3=O)ncc2-n2c(C)nnc12 InChI=1S/C51H64N12O7/c1-4-39-47-59-58-31(2)63(47)41-28-52-51(57-46(41)61(39)29-32-13-8-7-9-14-32)55-38-20-19-33(27-42(38)70-3)48(67)53-34-23-25-60(26-24-34)45(66)18-11-6-5-10-17-43(64)54-37-16-12-15-35-36(37)30-62(50(35)69)40-21-22-44(65)56-49(40)68/h12,15-16,19-20,27-28,32,34,39-40H,4-11,13-14,17-18,21-26,29-30H2,1-3H3,(H,53,67)(H,54,64)(H,52,55,57)(H,56,65,68)/t39-,40?/m1/s1 DKPUPJUELCIYFX-IPVUVHESSA-N 50599463 CHEMBL5173742 Serine/threonine-protein kinase PLK1 Homo sapiens 652 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599463&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168273971 482610315 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51487442 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H43N9O2/c1-5-25-29-37-36-20(2)40(29)26-18-32-31(35-28(26)39(25)19-21-9-7-6-8-10-21)34-24-12-11-22(17-27(24)42-4)30(41)33-23-13-15-38(3)16-14-23/h11-12,17-18,21,23,25H,5-10,13-16,19H2,1-4H3,(H,33,41)(H,32,34,35)/t25-/m1/s1 QUMCIHKVKQYNPA-RUZDIDTESA-N 50551271 CHEMBL4747491 Serine/threonine-protein kinase PLK1 Homo sapiens 22 ChEMBL 10.7270/Q2959NK1 34700270 Hu, R; Wang, WL; Yang, YY; Hu, XT; Wang, QW; Zuo, WQ; Xu, Y; Feng, Q; Wang, NY Southwest Jiaotong University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551271&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775102 461681611 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478337 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.7270/Q24Q801K 33539089 Raghuvanshi, R; Bharate, SB CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478394 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.083000 ChEMBL 10.7270/Q24Q801K 33539089 Raghuvanshi, R; Bharate, SB CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478830 CCCCc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C18H19NO3/c1-2-3-6-13-9-11-14(12-10-13)17(20)19-16-8-5-4-7-15(16)18(21)22/h4-5,7-12H,2-3,6H2,1H3,(H,19,20)(H,21,22) JCTORKRZDANGCM-UHFFFAOYSA-N 50596066 CHEMBL5185527 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596066&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 67043664 482606918 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478831 CCCCCc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C19H21NO3/c1-2-3-4-7-14-10-12-15(13-11-14)18(21)20-17-9-6-5-8-16(17)19(22)23/h5-6,8-13H,2-4,7H2,1H3,(H,20,21)(H,22,23) ZOELXJWPWNNTHY-UHFFFAOYSA-N 50596067 CHEMBL4864977 Serine/threonine-protein kinase PLK1 Homo sapiens 223600 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596067&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 86140144 482606919 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478832 CCCCCCc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C20H23NO3/c1-2-3-4-5-8-15-11-13-16(14-12-15)19(22)21-18-10-7-6-9-17(18)20(23)24/h6-7,9-14H,2-5,8H2,1H3,(H,21,22)(H,23,24) FKAZACXXFMQQFZ-UHFFFAOYSA-N 50581994 CHEMBL5087960 Serine/threonine-protein kinase PLK1 Homo sapiens 18400 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581994&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4105136 476026999 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478833 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C22H27NO3/c1-2-3-4-5-6-7-10-17-13-15-18(16-14-17)21(24)23-20-12-9-8-11-19(20)22(25)26/h8-9,11-16H,2-7,10H2,1H3,(H,23,24)(H,25,26) NCQBHTMKZRMQJH-UHFFFAOYSA-N 50596068 CHEMBL5178208 Serine/threonine-protein kinase PLK1 Homo sapiens 11300 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596068&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168275069 482606920 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478834 CCCCCCCCCCCCc1ccc(cc1)C(=O)Nc1ccccc1C(O)=O InChI=1S/C26H35NO3/c1-2-3-4-5-6-7-8-9-10-11-14-21-17-19-22(20-18-21)25(28)27-24-16-13-12-15-23(24)26(29)30/h12-13,15-20H,2-11,14H2,1H3,(H,27,28)(H,29,30) QYMVBKPRIPTDQQ-UHFFFAOYSA-N 50596069 CHEMBL5175899 Serine/threonine-protein kinase PLK1 Homo sapiens 6000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596069&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168273069 482606921 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478835 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C23H29NO3/c1-3-4-5-6-7-8-9-18-11-13-19(14-12-18)22(25)24-21-15-10-17(2)16-20(21)23(26)27/h10-16H,3-9H2,1-2H3,(H,24,25)(H,26,27) PFAWUGNNKWJJOU-UHFFFAOYSA-N 50596070 CHEMBL5180726 Serine/threonine-protein kinase PLK1 Homo sapiens 2200 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596070&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168271898 482606922 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478836 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(OC)cc1C(O)=O InChI=1S/C23H29NO4/c1-3-4-5-6-7-8-9-17-10-12-18(13-11-17)22(25)24-21-15-14-19(28-2)16-20(21)23(26)27/h10-16H,3-9H2,1-2H3,(H,24,25)(H,26,27) KTYYPWQXGNKUDD-UHFFFAOYSA-N 50596071 CHEMBL5179948 Serine/threonine-protein kinase PLK1 Homo sapiens 5900 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596071&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168272771 482606923 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478837 CCCCCCCCc1ccc(cc1)C(=O)Nc1cc(C)ccc1C(O)=O InChI=1S/C23H29NO3/c1-3-4-5-6-7-8-9-18-11-13-19(14-12-18)22(25)24-21-16-17(2)10-15-20(21)23(26)27/h10-16H,3-9H2,1-2H3,(H,24,25)(H,26,27) ZYOSGTAOCVADAY-UHFFFAOYSA-N 50596072 CHEMBL5209469 Serine/threonine-protein kinase PLK1 Homo sapiens 4000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596072&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168295964 482606924 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478838 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccccc1C(=O)OCC InChI=1S/C24H31NO3/c1-3-5-6-7-8-9-12-19-15-17-20(18-16-19)23(26)25-22-14-11-10-13-21(22)24(27)28-4-2/h10-11,13-18H,3-9,12H2,1-2H3,(H,25,26) GDLPMAKUBXXNTO-UHFFFAOYSA-N 50596073 CHEMBL5202121 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596073&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168291660 482606925 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478839 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccccc1B(O)O InChI=1S/C21H28BNO3/c1-2-3-4-5-6-7-10-17-13-15-18(16-14-17)21(24)23-20-12-9-8-11-19(20)22(25)26/h8-9,11-16,25-26H,2-7,10H2,1H3,(H,23,24) UHLTXJRKWNWQRF-UHFFFAOYSA-N 50596074 CHEMBL5178662 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596074&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168273760 482606926 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478840 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccccc1[N+]([O-])=O InChI=1S/C21H26N2O3/c1-2-3-4-5-6-7-10-17-13-15-18(16-14-17)21(24)22-19-11-8-9-12-20(19)23(25)26/h8-9,11-16H,2-7,10H2,1H3,(H,22,24) FWDKCOOXLASVJH-UHFFFAOYSA-N 50596075 CHEMBL5177850 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596075&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168272194 482606927 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478841 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccccc1S(N)(=O)=O InChI=1S/C21H28N2O3S/c1-2-3-4-5-6-7-10-17-13-15-18(16-14-17)21(24)23-19-11-8-9-12-20(19)27(22,25)26/h8-9,11-16H,2-7,10H2,1H3,(H,23,24)(H2,22,25,26) OVRAZCFZNCBREA-UHFFFAOYSA-N 50596076 CHEMBL5178482 Serine/threonine-protein kinase PLK1 Homo sapiens 259100 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596076&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168274206 482606928 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478842 CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(OP(O)(O)=O)c1 InChI=1S/C21H28NO5P/c1-2-3-4-5-6-7-9-17-12-14-18(15-13-17)21(23)22-19-10-8-11-20(16-19)27-28(24,25)26/h8,10-16H,2-7,9H2,1H3,(H,22,23)(H2,24,25,26) YPMVMBQADLENPO-UHFFFAOYSA-N 50596077 CHEMBL5206566 Serine/threonine-protein kinase PLK1 Homo sapiens 98300 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596077&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168296524 482606929 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478843 CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(F)c1C(O)=O InChI=1S/C22H26FNO3/c1-2-3-4-5-6-7-9-16-12-14-17(15-13-16)21(25)24-19-11-8-10-18(23)20(19)22(26)27/h8,10-15H,2-7,9H2,1H3,(H,24,25)(H,26,27) FPRAMQBRQOODHW-UHFFFAOYSA-N 50596078 CHEMBL5183088 Serine/threonine-protein kinase PLK1 Homo sapiens 11100 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596078&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168280512 482606930 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478844 CCCCCCCCc1ccc(cc1)C(=O)Nc1cc(F)cc(F)c1C(O)=O InChI=1S/C22H25F2NO3/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)21(26)25-19-14-17(23)13-18(24)20(19)22(27)28/h9-14H,2-8H2,1H3,(H,25,26)(H,27,28) QRBAKDKCBMOLDC-UHFFFAOYSA-N 50596079 CHEMBL5190849 Serine/threonine-protein kinase PLK1 Homo sapiens 30600 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596079&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168280803 482606931 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478845 CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(c1C(O)=O)[N+]([O-])=O InChI=1S/C22H26N2O5/c1-2-3-4-5-6-7-9-16-12-14-17(15-13-16)21(25)23-18-10-8-11-19(24(28)29)20(18)22(26)27/h8,10-15H,2-7,9H2,1H3,(H,23,25)(H,26,27) SGXPKENGJLCDRE-UHFFFAOYSA-N 50596080 CHEMBL5182503 Serine/threonine-protein kinase PLK1 Homo sapiens 6100 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596080&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168280847 482606932 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478846 CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(c1C(O)=O)C(F)(F)F InChI=1S/C23H26F3NO3/c1-2-3-4-5-6-7-9-16-12-14-17(15-13-16)21(28)27-19-11-8-10-18(23(24,25)26)20(19)22(29)30/h8,10-15H,2-7,9H2,1H3,(H,27,28)(H,29,30) ZUJVUTHFABRAQK-UHFFFAOYSA-N 50596081 CHEMBL5204555 Serine/threonine-protein kinase PLK1 Homo sapiens 29400 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596081&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168295101 482606933 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478847 CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(O)c1C(O)=O InChI=1S/C22H27NO4/c1-2-3-4-5-6-7-9-16-12-14-17(15-13-16)21(25)23-18-10-8-11-19(24)20(18)22(26)27/h8,10-15,24H,2-7,9H2,1H3,(H,23,25)(H,26,27) VRHRZVBXMNDQKQ-UHFFFAOYSA-N 50596082 CHEMBL5183471 Serine/threonine-protein kinase PLK1 Homo sapiens 7900 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596082&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168279810 482606934 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478848 CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(OC)c1C(O)=O InChI=1S/C23H29NO4/c1-3-4-5-6-7-8-10-17-13-15-18(16-14-17)22(25)24-19-11-9-12-20(28-2)21(19)23(26)27/h9,11-16H,3-8,10H2,1-2H3,(H,24,25)(H,26,27) OLLFQLNKVJENRB-UHFFFAOYSA-N 50596083 CHEMBL5181122 Serine/threonine-protein kinase PLK1 Homo sapiens 29600 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596083&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168275990 482606935 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478849 CCCCCCCCc1ccc(cc1)C(=O)Nc1c(O)cccc1C(O)=O InChI=1S/C22H27NO4/c1-2-3-4-5-6-7-9-16-12-14-17(15-13-16)21(25)23-20-18(22(26)27)10-8-11-19(20)24/h8,10-15,24H,2-7,9H2,1H3,(H,23,25)(H,26,27) WZYFDADMQHUIES-UHFFFAOYSA-N 50596084 CHEMBL5173392 Serine/threonine-protein kinase PLK1 Homo sapiens 12000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596084&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168271528 482606936 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478850 CCCCCCCCc1ccc(cc1)C(=O)Nc1cccc(Cl)c1C(O)=O InChI=1S/C22H26ClNO3/c1-2-3-4-5-6-7-9-16-12-14-17(15-13-16)21(25)24-19-11-8-10-18(23)20(19)22(26)27/h8,10-15H,2-7,9H2,1H3,(H,24,25)(H,26,27) ACGYBQYWOVGDTP-UHFFFAOYSA-N 50596085 CHEMBL5207741 Serine/threonine-protein kinase PLK1 Homo sapiens 25300 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168294657 482606937 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478851 CCCCCCCCc1ccc(CNc2ccccc2C(O)=O)cc1 InChI=1S/C22H29NO2/c1-2-3-4-5-6-7-10-18-13-15-19(16-14-18)17-23-21-12-9-8-11-20(21)22(24)25/h8-9,11-16,23H,2-7,10,17H2,1H3,(H,24,25) JSOGMRXQFVIMQK-UHFFFAOYSA-N 50596086 CHEMBL5173820 Serine/threonine-protein kinase PLK1 Homo sapiens 9800 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596086&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168276847 482606938 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478852 CCCCCCCCc1ccc(CNc2cccc(OP(O)(O)=O)c2)cc1 InChI=1S/C21H30NO4P/c1-2-3-4-5-6-7-9-18-12-14-19(15-13-18)17-22-20-10-8-11-21(16-20)26-27(23,24)25/h8,10-16,22H,2-7,9,17H2,1H3,(H2,23,24,25) DIDYWWUDWCHFQV-UHFFFAOYSA-N 50596087 CHEMBL5176465 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596087&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168274110 482606939 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478853 CCCCCCCCc1ccc(CNc2ccc(C)cc2C(O)=O)cc1 InChI=1S/C23H31NO2/c1-3-4-5-6-7-8-9-19-11-13-20(14-12-19)17-24-22-15-10-18(2)16-21(22)23(25)26/h10-16,24H,3-9,17H2,1-2H3,(H,25,26) QCEQPJFHRHJMKP-UHFFFAOYSA-N 50596088 CHEMBL5174046 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596088&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168273528 482606940 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478854 CCCCCCCCc1ccc(CNc2cc(C)ccc2C(O)=O)cc1 InChI=1S/C23H31NO2/c1-3-4-5-6-7-8-9-19-11-13-20(14-12-19)17-24-22-16-18(2)10-15-21(22)23(25)26/h10-16,24H,3-9,17H2,1-2H3,(H,25,26) ZMXVMOOSDRHTOI-UHFFFAOYSA-N 50596089 CHEMBL5196414 Serine/threonine-protein kinase PLK1 Homo sapiens 21700 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596089&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168284373 482606941 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478855 CCCCCCCCc1ccc(CCNc2ccccc2C(O)=O)cc1 InChI=1S/C23H31NO2/c1-2-3-4-5-6-7-10-19-13-15-20(16-14-19)17-18-24-22-12-9-8-11-21(22)23(25)26/h8-9,11-16,24H,2-7,10,17-18H2,1H3,(H,25,26) KYZRKKYIQJGZHD-UHFFFAOYSA-N 50596090 CHEMBL5169598 Serine/threonine-protein kinase PLK1 Homo sapiens 117500 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596090&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168270393 482606942 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478856 CCCCCCCCc1ccc(CNc2cccc(F)c2C(O)=O)cc1 InChI=1S/C22H28FNO2/c1-2-3-4-5-6-7-9-17-12-14-18(15-13-17)16-24-20-11-8-10-19(23)21(20)22(25)26/h8,10-15,24H,2-7,9,16H2,1H3,(H,25,26) FQTWWBVFQSGJEM-UHFFFAOYSA-N 50596091 CHEMBL5195887 Serine/threonine-protein kinase PLK1 Homo sapiens 18800 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596091&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168292505 482606943 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478857 CCCCCCCCc1ccc(CNc2cccc(CC)c2)cc1 InChI=1S/C23H33N/c1-3-5-6-7-8-9-11-21-14-16-22(17-15-21)19-24-23-13-10-12-20(4-2)18-23/h10,12-18,24H,3-9,11,19H2,1-2H3 PXFYWCIMFDZBDI-UHFFFAOYSA-N 50596092 CHEMBL5175885 Serine/threonine-protein kinase PLK1 Homo sapiens >600000 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596092&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168272535 482606944 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51478869 CCCCCCCCc1ccc(cc1)C(=O)Nc1ccc(C)cc1C(O)=O InChI=1S/C23H29NO3/c1-3-4-5-6-7-8-9-18-11-13-19(14-12-18)22(25)24-21-15-10-17(2)16-20(21)23(26)27/h10-16H,3-9H2,1-2H3,(H,24,25)(H,26,27) PFAWUGNNKWJJOU-UHFFFAOYSA-N 50596070 CHEMBL5180726 Serine/threonine-protein kinase PLK1 Homo sapiens 820 ChEMBL 10.7270/Q2G164T0 34735919 Craig, SN; Baxter, M; Chapagai, D; Stafford, JM; Nurmemmedov, E; Altomare, D; Wyatt, MD; McInnes, C University of South Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50596070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50596070&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168271898 482606922 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476845 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 8.0 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476848 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1 InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31) BKWJAKQVGHWELA-UHFFFAOYSA-N 50240826 AZD-1775::MK-1775::US11124518, Example AZD1775::US11248006, Compound AZD1775::US11479555, Example AZD1775 Serine/threonine-protein kinase PLK1 Homo sapiens 15 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 8X7 5VDK,5VD0,5V5Y,8BJT 24856436 386401532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476850 Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccccc1 InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H FXNFHKRTJBSTCS-UHFFFAOYSA-N 50009001 5,6,7-Trihydroxyflavone::5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one::Baicalein::Baicalein, 14::Baicalein, 8::CHEMBL8260::US10252984, Table 2.33 Serine/threonine-protein kinase PLK1 Homo sapiens 9000 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50009001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50009001&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 3WL 7XAX,6M2N,8A0Q,4X2A 5281605 103922066 2979 CHEMBL8260 5144 C10023 ZINC03871633 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476851 COc1cc(O)c2c(oc(cc2=O)-c2ccccc2)c1OC InChI=1S/C17H14O5/c1-20-14-9-12(19)15-11(18)8-13(10-6-4-3-5-7-10)22-17(15)16(14)21-2/h3-9,19H,1-2H3 IHLSBQVBFDTNTC-UHFFFAOYSA-N 50595385 Moslosooflavone Serine/threonine-protein kinase PLK1 Homo sapiens 10200 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595385&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 188316 482606237 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476852 Oc1cc2O[C@@H](CC(=O)c2c(O)c1O)c1ccccc1 InChI=1S/C15H12O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-5,7,11,17-19H,6H2/t11-/m0/s1 GPDJGLOROGNHJD-NSHDSACASA-N 50595386 (2S)-Dihydrobaicalein::CHEMBL402227 Serine/threonine-protein kinase PLK1 Homo sapiens 6300 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595386&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 14135323 482606238 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476859 O[C@H]1[C@H](Oc2cc3oc(cc(=O)c3c(O)c2O)-c2ccccc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1 IKIIZLYTISPENI-ZFORQUDYSA-N 50242173 (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid::Baicali::Baicalin (9)::CHEMBL485818::baicalin Serine/threonine-protein kinase PLK1 Homo sapiens 3610 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242173&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 0XE 4H2B,4Q2V 64982 104098972 2981 CHEMBL485818 C03033 ZINC03943903 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476860 COc1ccc(CCNCc2ccc(OCc3ccc(Cl)nc3)c(OC)c2)cc1OC InChI=1S/C24H27ClN2O4/c1-28-20-7-4-17(12-22(20)29-2)10-11-26-14-18-5-8-21(23(13-18)30-3)31-16-19-6-9-24(25)27-15-19/h4-9,12-13,15,26H,10-11,14,16H2,1-3H3 XNPRQBVQOJZMMA-UHFFFAOYSA-N 50595387 CHEMBL1625188 Serine/threonine-protein kinase PLK1 Homo sapiens 200 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595387&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 4719406 482606239 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476861 Cc1onc(c1\C=C1/C(=O)Nc2ccccc12)-c1ccccc1 InChI=1S/C19H14N2O2/c1-12-15(18(21-23-12)13-7-3-2-4-8-13)11-16-14-9-5-6-10-17(14)20-19(16)22/h2-11H,1H3,(H,20,22)/b16-11- SDKXUNMTVUXBRG-WJDWOHSUSA-N 50595388 CHEMBL5202429 Serine/threonine-protein kinase PLK1 Homo sapiens 20000 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595388&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 5702988 482606240 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476862 Cc1ccc(NC(=S)NCCNc2nccc(n2)C(F)(F)F)c(C)c1 InChI=1S/C16H18F3N5S/c1-10-3-4-12(11(2)9-10)23-15(25)22-8-7-21-14-20-6-5-13(24-14)16(17,18)19/h3-6,9H,7-8H2,1-2H3,(H,20,21,24)(H2,22,23,25) QBEVZPUMIZVBQU-UHFFFAOYSA-N 50595389 CHEMBL5172400 Serine/threonine-protein kinase PLK1 Homo sapiens 1000 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595389&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2795821 482606241 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476863 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 UIYQCJDQBRUFEV-FALOATQWSA-N 50403017 CHEMBL2207846 Serine/threonine-protein kinase PLK1 Homo sapiens 36000 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49873221 163352041 CHEMBL2207846 ZINC95564030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476864 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCCCCCc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C40H63N8O11P/c1-26(2)21-31(44-40(55)34-18-14-20-48(34)28(4)50)37(52)43-32(38(53)45-33(24-49)39(54)46-35(36(41)51)27(3)59-60(56,57)58)22-30-23-42-25-47(30)19-13-8-6-5-7-10-15-29-16-11-9-12-17-29/h9,11-12,16-17,23,25-27,31-35,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,41,51)(H,43,52)(H,44,55)(H,45,53)(H,46,54)(H2,56,57,58)/t27-,31+,32+,33+,34+,35+/m1/s1 ZDQJNYLFGPXANH-BKXCAEITSA-N 50403016 CHEMBL2207845 Serine/threonine-protein kinase PLK1 Homo sapiens 17 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403016&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53249964 163352040 CHEMBL2207845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476865 C[C@H](OP(O)(O)=O)[C@H](NC(=O)c1ccc2n(CCc3ccccc3)c(CCCCc3ccccc3)nc2c1)C(N)=O InChI=1S/C30H35N4O6P/c1-21(40-41(37,38)39)28(29(31)35)33-30(36)24-16-17-26-25(20-24)32-27(15-9-8-14-22-10-4-2-5-11-22)34(26)19-18-23-12-6-3-7-13-23/h2-7,10-13,16-17,20-21,28H,8-9,14-15,18-19H2,1H3,(H2,31,35)(H,33,36)(H2,37,38,39)/t21-,28-/m0/s1 PVJWQPTVFADMRO-KMRXNPHXSA-N 50595390 CHEMBL5173743 Serine/threonine-protein kinase PLK1 Homo sapiens 4500 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595390&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168273972 482606242 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476866 CC(C)C[C@H](NC(=O)[C@@H]1C[C@H](CN1C(C)=O)O\N=C\CCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O 50595391 CHEMBL5194102 Serine/threonine-protein kinase PLK1 Homo sapiens 122 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595391&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49872721 482606243 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476867 CC(C)C[C@H](NC(=O)[C@@H]1C[C@H](CN1C(C)=O)OCCCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O 50595392 CHEMBL5185686 Serine/threonine-protein kinase PLK1 Homo sapiens 14 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595392&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49872325 482606244 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476868 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cncn1CCCCc1cn(Cc2ccc(Oc3ccccc3)cc2F)nn1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C45H61FN11O12P/c1-27(2)19-36(50-45(64)39-14-10-18-57(39)29(4)59)42(61)49-37(43(62)51-38(25-58)44(63)52-40(41(47)60)28(3)69-70(65,66)67)20-32-22-48-26-55(32)17-9-8-11-31-24-56(54-53-31)23-30-15-16-34(21-35(30)46)68-33-12-6-5-7-13-33/h5-7,12-13,15-16,21-22,24,26-28,36-40,58H,8-11,14,17-20,23,25H2,1-4H3,(H2,47,60)(H,49,61)(H,50,64)(H,51,62)(H,52,63)(H2,65,66,67)/t28-,36+,37+,38+,39+,40+/m1/s1 RZLGHTUEKVZIMB-UFSHPFNLSA-N 50595393 CHEMBL5170038 Serine/threonine-protein kinase PLK1 Homo sapiens 25 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595393&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168270869 482606245 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476869 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cn(CCCCCCCCc2ccccc2)nn1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C39H62N9O11P/c1-25(2)21-30(42-39(55)33-18-14-20-48(33)27(4)50)36(52)41-31(37(53)43-32(24-49)38(54)44-34(35(40)51)26(3)59-60(56,57)58)22-29-23-47(46-45-29)19-13-8-6-5-7-10-15-28-16-11-9-12-17-28/h9,11-12,16-17,23,25-26,30-34,49H,5-8,10,13-15,18-22,24H2,1-4H3,(H2,40,51)(H,41,52)(H,42,55)(H,43,53)(H,44,54)(H2,56,57,58)/t26-,30+,31+,32+,33+,34+/m1/s1 VZLKEAGJBNAJKB-DZPCQTFRSA-N 50595394 CHEMBL5196402 Serine/threonine-protein kinase PLK1 Homo sapiens 17 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595394&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168285900 482606246 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476876 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@H]1C[C@H](CCCCCCCCc2ccccc2)C(=O)NCCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC1=O)[C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C44H71N8O13P/c1-27(2)24-33(49-43(60)36-21-15-23-52(36)29(4)54)40(57)48-34-25-31(19-13-8-6-5-7-10-16-30-17-11-9-12-18-30)39(56)46-22-14-20-32(38(45)55)47-44(61)37(28(3)65-66(62,63)64)51-42(59)35(26-53)50-41(34)58/h9,11-12,17-18,27-28,31-37,53H,5-8,10,13-16,19-26H2,1-4H3,(H2,45,55)(H,46,56)(H,47,61)(H,48,57)(H,49,60)(H,50,58)(H,51,59)(H2,62,63,64)/t28-,31+,32+,33+,34+,35+,36+,37+/m1/s1 AJJBWPRLFOMJCY-GUJGKPLJSA-N 50595395 CHEMBL5179633 Serine/threonine-protein kinase PLK1 Homo sapiens 5.0 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595395&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168273287 482606247 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476879 CC(C)C1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O InChI=1S/C18H19NO3/c1-11(2)15-10-16(13(4)9-17(15)20)19-22-18(21)14-8-6-5-7-12(14)3/h5-11H,1-4H3/b19-16- CMOJHDQJJPIVEC-MNDPQUGUSA-N 50206448 CHEMBL3944542 Serine/threonine-protein kinase PLK1 Homo sapiens 4800 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206448&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 9613592 375981109 CHEMBL3944542 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476880 O=c1ccc(-c2ccc3ccccc3c2)c2[C@@H]3C[C@@H](CN(Cc4cccc(c4)C#N)C3)Cn12 InChI=1S/C29H25N3O/c30-15-20-4-3-5-21(12-20)16-31-17-22-13-26(19-31)29-27(10-11-28(33)32(29)18-22)25-9-8-23-6-1-2-7-24(23)14-25/h1-12,14,22,26H,13,16-19H2/t22-,26+/m0/s1 DRTMJXOVPWKHSS-BKMJKUGQSA-N 50595396 CHEMBL5196864 Serine/threonine-protein kinase PLK1 Homo sapiens 17900 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595396&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7674813 482606248 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476883 CC1=C\C(=N\OC(=O)c2ccccc2C)C(C)=CC1=O InChI=1S/C16H15NO3/c1-10-6-4-5-7-13(10)16(19)20-17-14-8-12(3)15(18)9-11(14)2/h4-9H,1-3H3/b17-14- KWDBXGNIGYVOBI-VKAVYKQESA-N 50595397 CHEMBL4467651 Serine/threonine-protein kinase PLK1 Homo sapiens 1360 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595397&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44188683 482606249 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476886 CC1=C\C(=N\OC(=O)c2ccc(CNC(=O)CCc3cn(CCCCCCOCCOCCNC(=O)CC45CC6CC(CC(C6)C4)C5)nn3)cc2C)C(C)=CC1=O InChI=1S/C44H60N6O7/c1-30-18-33(8-10-38(30)43(54)57-48-39-19-32(3)40(51)20-31(39)2)28-46-41(52)11-9-37-29-50(49-47-37)13-6-4-5-7-14-55-16-17-56-15-12-45-42(53)27-44-24-34-21-35(25-44)23-36(22-34)26-44/h8,10,18-20,29,34-36H,4-7,9,11-17,21-28H2,1-3H3,(H,45,53)(H,46,52)/b48-39- ORIFCQKRWMWFOX-HCTBILRNSA-N 50595398 CHEMBL5197718 Serine/threonine-protein kinase PLK1 Homo sapiens 10500 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595398&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168288535 482606250 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476887 C[C@H](CCC12CC3CC(CC(C3)C1)C2)C(=O)NCCOCCOCCCCCCn1cc(CCC(=O)NCc2ccc(C(=O)O\N=C3\C=C(C)C(=O)C=C3C)c(C)c2)nn1 InChI=1S/C47H66N6O7/c1-32(13-14-47-27-37-24-38(28-47)26-39(25-37)29-47)45(56)48-15-18-59-20-19-58-17-8-6-5-7-16-53-31-40(50-52-53)10-12-44(55)49-30-36-9-11-41(33(2)21-36)46(57)60-51-42-22-35(4)43(54)23-34(42)3/h9,11,21-23,31-32,37-39H,5-8,10,12-20,24-30H2,1-4H3,(H,48,56)(H,49,55)/b51-42-/t32-,37?,38?,39?,47?/m1/s1 BQXHVNSZFNOCDQ-IUSJNPHJSA-N 50595399 CHEMBL5202954 Serine/threonine-protein kinase PLK1 Homo sapiens 48200 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595399&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168292726 482606251 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476889 Fc1ccc2c(c1)c(=O)n(CCC(F)(F)F)c1n[nH]c(=S)n21 InChI=1S/C12H8F4N4OS/c13-6-1-2-8-7(5-6)9(21)19(4-3-12(14,15)16)10-17-18-11(22)20(8)10/h1-2,5H,3-4H2,(H,18,22) KQLVCCQCJZYYBX-UHFFFAOYSA-N 50548886 CHEMBL4755597 Serine/threonine-protein kinase PLK1 Homo sapiens 750 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548886&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655125 461679226 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476890 Fc1ccc2c(c1)c(=O)n(CC1CC1)c1n[nH]c(=S)n21 InChI=1S/C13H11FN4OS/c14-8-3-4-10-9(5-8)11(19)17(6-7-1-2-7)12-15-16-13(20)18(10)12/h3-5,7H,1-2,6H2,(H,16,20) JSRQZDANZDRJOA-UHFFFAOYSA-N 50548834 CHEMBL4786053 Serine/threonine-protein kinase PLK1 Homo sapiens 770 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548834&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667407 461679174 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476891 Fc1ccc2c(c1)c(=O)n(CCc1ccccn1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-10-4-5-13-12(9-10)14(23)21(15-19-20-16(24)22(13)15)8-6-11-3-1-2-7-18-11/h1-5,7,9H,6,8H2,(H,20,24) DKCRYDVGUXVEGT-UHFFFAOYSA-N 50548903 CHEMBL4755098 Serine/threonine-protein kinase PLK1 Homo sapiens 870 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548903&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654749 461679243 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476892 Fc1ccc2c(c1)c(=O)n(CCc1ccncc1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-11-1-2-13-12(9-11)14(23)21(15-19-20-16(24)22(13)15)8-5-10-3-6-18-7-4-10/h1-4,6-7,9H,5,8H2,(H,20,24) ZMGSXMDCXVONSV-UHFFFAOYSA-N 50548905 CHEMBL4755584 Serine/threonine-protein kinase PLK1 Homo sapiens 890 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548905&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656087 461679245 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476893 COc1cccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)c1 InChI=1S/C21H20FN5O3S/c1-30-15-5-2-4-13(10-15)11-18(28)23-8-3-9-26-19(29)16-12-14(22)6-7-17(16)27-20(26)24-25-21(27)31/h2,4-7,10,12H,3,8-9,11H2,1H3,(H,23,28)(H,25,31) ARRRHZTVWRSLIH-UHFFFAOYSA-N 50548949 CHEMBL4782750 Serine/threonine-protein kinase PLK1 Homo sapiens 960 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548949&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664368 461679289 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476894 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccc(cc1)C#N)c1n[nH]c(=S)n21 InChI=1S/C21H17FN6O2S/c22-15-6-7-17-16(11-15)19(30)27(20-25-26-21(31)28(17)20)9-1-8-24-18(29)10-13-2-4-14(12-23)5-3-13/h2-7,11H,1,8-10H2,(H,24,29)(H,26,31) OCVKYBDQGXTDAN-UHFFFAOYSA-N 50548954 CHEMBL4779347 Serine/threonine-protein kinase PLK1 Homo sapiens 990 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548954&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663133 461679294 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476895 CCCCCCCCCC1=CO[C@]2(C[C@H](C(O)=O)[C@](CC(O)=O)(O2)C(=O)OCCCC)C1=O InChI=1S/C24H36O9/c1-3-5-7-8-9-10-11-12-17-16-32-24(20(17)27)14-18(21(28)29)23(33-24,15-19(25)26)22(30)31-13-6-4-2/h16,18H,3-15H2,1-2H3,(H,25,26)(H,28,29)/t18-,23+,24+/m1/s1 QVSWRRPJGDCTOZ-DKLXNKCPSA-N 50595400 CHEMBL5185032 Serine/threonine-protein kinase PLK1 Homo sapiens 102000 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595400&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 132571541 482606252 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476896 CCCCCCCCCC1=CO[C@]2(C[C@H](C(O)=O)[C@](CC(O)=O)(O2)C(O)=O)C1=O InChI=1S/C20H28O9/c1-2-3-4-5-6-7-8-9-13-12-28-20(16(13)23)10-14(17(24)25)19(29-20,18(26)27)11-15(21)22/h12,14H,2-11H2,1H3,(H,21,22)(H,24,25)(H,26,27)/t14-,19+,20+/m1/s1 LQLCHKHILFZNKF-UAOJZALGSA-N 50595401 CHEMBL5175115 Serine/threonine-protein kinase PLK1 Homo sapiens 128000 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595401&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 11729317 482606253 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51476897 [I-].COc1c2OCOc2cc2CC[N+](C)(C)C(CC(=O)c3ccccn3)c12 InChI=1S/C20H23N2O4.HI/c1-22(2)9-7-13-10-17-19(26-12-25-17)20(24-3)18(13)15(22)11-16(23)14-6-4-5-8-21-14;/h4-6,8,10,15H,7,9,11-12H2,1-3H3;1H/q+1;/p-1 VXNNIRQUVOWRGO-UHFFFAOYSA-M 50595402 CHEMBL5177415 Serine/threonine-protein kinase PLK1 Homo sapiens 2100 ChEMBL 10.7270/Q2Z89HD2 35878418 Zhang, J; Zhang, L; Wang, J; Ouyang, L; Wang, Y West China Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595402&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 44667584 482606254 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51455681 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Serine/threonine-protein kinase PLK1 Homo sapiens 2.2 ChEMBL 10.7270/Q23X8BM3 33356242 Faisal, M; Kim, JH; Yoo, KH; Roh, EJ; Hong, SS; Lee, SH University of Science and Technology (UST) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456188 COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1 InChI=1S/C27H34F3N7O3/c1-35-10-8-16(9-11-35)32-24(38)18-12-22(40-3)20(13-19(18)28)33-26-31-14-21-23(34-26)37(17-6-4-5-7-17)15-27(29,30)25(39)36(21)2/h12-14,16-17H,4-11,15H2,1-3H3,(H,32,38)(H,31,33,34) GWRSATNRNFYMDI-UHFFFAOYSA-N 50435727 CHEMBL2392545 Serine/threonine-protein kinase PLK1 Homo sapiens 0.800000 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435727&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1J4 4J53 53357478 175448044 CHEMBL2392545 ZINC43203898 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456189 COc1cc2ncn(-c3cc(c(s3)C(N)=O)-c3cccc(c3)C(F)(F)F)c2cc1OC InChI=1S/C21H16F3N3O3S/c1-29-16-8-14-15(9-17(16)30-2)27(10-26-14)18-7-13(19(31-18)20(25)28)11-4-3-5-12(6-11)21(22,23)24/h3-10H,1-2H3,(H2,25,28) XWYZKOYPUHEFPY-UHFFFAOYSA-N 50587787 CHEMBL5190855 Serine/threonine-protein kinase PLK1 Homo sapiens 2.2 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587787&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168283654 482598639 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456190 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456191 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O InChI=1S/C26H43N8O11P/c1-13(2)8-17(31-26(41)20-6-5-7-34(20)15(4)36)23(38)30-18(9-16-10-28-12-29-16)24(39)32-19(11-35)25(40)33-21(22(27)37)14(3)45-46(42,43)44/h10,12-14,17-21,35H,5-9,11H2,1-4H3,(H2,27,37)(H,28,29)(H,30,38)(H,31,41)(H,32,39)(H,33,40)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 UIYQCJDQBRUFEV-FALOATQWSA-N 50403017 CHEMBL2207846 Serine/threonine-protein kinase PLK1 Homo sapiens 445 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50403017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50403017&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 49873221 163352041 CHEMBL2207846 ZINC95564030 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456192 C[C@H](CC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(N)=O)c1cncs1)NC(=O)c1ccc(CO)cc1 InChI=1S/C24H33N6O11PS/c1-12(27-22(35)15-5-3-14(9-31)4-6-15)7-18(33)29-20(17-8-26-11-43-17)24(37)28-16(10-32)23(36)30-19(21(25)34)13(2)41-42(38,39)40/h3-6,8,11-13,16,19-20,31-32H,7,9-10H2,1-2H3,(H2,25,34)(H,27,35)(H,28,37)(H,29,33)(H,30,36)(H2,38,39,40)/t12-,13-,16+,19+,20+/m1/s1 XGFTVGHRWHLBOH-TZFCGUKBSA-N 50587788 CHEMBL5175599 Serine/threonine-protein kinase PLK1 Homo sapiens 267 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587788&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168276116 482598640 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456193 C[C@@]12CN(Cc3cccc(c3)C#N)C[C@@](C)(C1)c1c(ccc(=O)n1C2)-c1ccc2ccccc2c1 InChI=1S/C31H29N3O/c1-30-18-31(2,21-33(19-30)17-23-7-5-6-22(14-23)16-32)29-27(12-13-28(35)34(29)20-30)26-11-10-24-8-3-4-9-25(24)15-26/h3-15H,17-21H2,1-2H3/t30-,31+/m0/s1 YATYWMOJLKTXCL-IOWSJCHKSA-N 50587786 CHEMBL5192049 Serine/threonine-protein kinase PLK1 Homo sapiens 17900 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587786&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168289449 482598638 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456194 C[C@@]12CN(Cc3cccc(c3)C#N)C[C@@](C)(C1)c1c(ccc(=O)n1C2)-c1ccc2ccccc2c1 InChI=1S/C31H29N3O/c1-30-18-31(2,21-33(19-30)17-23-7-5-6-22(14-23)16-32)29-27(12-13-28(35)34(29)20-30)26-11-10-24-8-3-4-9-25(24)15-26/h3-15H,17-21H2,1-2H3/t30-,31+/m0/s1 YATYWMOJLKTXCL-IOWSJCHKSA-N 50587786 CHEMBL5192049 Serine/threonine-protein kinase PLK1 Homo sapiens 17900 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587786&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168289449 482598638 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456196 CCOC(=O)c1oc2ccccc2c1CBr InChI=1S/C12H11BrO3/c1-2-15-12(14)11-9(7-13)8-5-3-4-6-10(8)16-11/h3-6H,2,7H2,1H3 AHTASHQCOAXTTF-UHFFFAOYSA-N 50587789 CHEMBL5188203 Serine/threonine-protein kinase PLK1 Homo sapiens 16400 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587789&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2317225 482598641 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51456197 CCOC(=O)c1oc2ccccc2c1CBr InChI=1S/C12H11BrO3/c1-2-15-12(14)11-9(7-13)8-5-3-4-6-10(8)16-11/h3-6H,2,7H2,1H3 AHTASHQCOAXTTF-UHFFFAOYSA-N 50587789 CHEMBL5188203 Serine/threonine-protein kinase PLK1 Homo sapiens 12770 ChEMBL 10.7270/Q2X63RWZ 33765606 Zhang, Z; Xing, X; Guan, P; Song, S; You, G; Xia, C; Liu, T Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50587789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50587789&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2317225 482598641 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51473937 OCc1ccc(cc1)C(=O)NCCC(=O)N[C@@H](Cc1cnnn1CCc1ccccc1)C(=O)NCc1cn(CCP(O)(O)=O)nn1 InChI=1S/C29H36N9O7P/c39-20-22-6-8-23(9-7-22)28(41)30-12-10-27(40)33-26(16-25-18-32-35-38(25)13-11-21-4-2-1-3-5-21)29(42)31-17-24-19-37(36-34-24)14-15-46(43,44)45/h1-9,18-19,26,39H,10-17,20H2,(H,30,41)(H,31,42)(H,33,40)(H2,43,44,45)/t26-/m0/s1 JRQHUXPKLSLAGY-SANMLTNESA-N 50594621 CHEMBL5186020 Serine/threonine-protein kinase PLK1 Homo sapiens 3370 ChEMBL 10.7270/Q2833X1W 33158576 Liu, T; Song, S; Wang, X; Hao, J Shandong First Medical University & Shandong Academy of Medical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594621&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168283449 482605473 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328229 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)nc(C)c2N(C)C1=O InChI=1S/C21H24FN7O/c1-13-18-19(27(3)14(2)20(30)28(18)4)26-21(25-13)23-9-16-10-24-29(12-16)11-15-5-7-17(22)8-6-15/h5-8,10,12,14H,9,11H2,1-4H3,(H,23,25,26)/t14-/m0/s1 BRBYLSUQUSFJQD-AWEZNQCLSA-N 622504 US20230312587, Compound 1 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622504&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194615 485229637 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328230 CC[C@]1(C)N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc2N(C)C1=O InChI=1S/C22H26FN7O/c1-5-22(2)20(31)28(3)18-12-25-21(27-19(18)29(22)4)24-10-16-11-26-30(14-16)13-15-6-8-17(23)9-7-15/h6-9,11-12,14H,5,10,13H2,1-4H3,(H,24,25,27)/t22-/m0/s1 JZEVKMSDTJOOJK-QFIPXVFZSA-N 622525 US20230312587, Compound 2 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622525&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194149 485229658 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328231 CC[C@@]1(C)N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc2N(C)C1=O InChI=1S/C22H26FN7O/c1-5-22(2)20(31)28(3)18-12-25-21(27-19(18)29(22)4)24-10-16-11-26-30(14-16)13-15-6-8-17(23)9-7-15/h6-9,11-12,14H,5,10,13H2,1-4H3,(H,24,25,27)/t22-/m1/s1 JZEVKMSDTJOOJK-JOCHJYFZSA-N 622526 US20230312587, Compound 3 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622526&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194966 485229659 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328232 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)nc(C)c2NC1=O InChI=1S/C20H22FN7O/c1-12-17-18(27(3)13(2)19(29)25-17)26-20(24-12)22-8-15-9-23-28(11-15)10-14-4-6-16(21)7-5-14/h4-7,9,11,13H,8,10H2,1-3H3,(H,25,29)(H,22,24,26)/t13-/m0/s1 MRSNHLWSHGAFRX-ZDUSSCGKSA-N 622527 US20230312587, Compound 4 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622527&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194492 485229660 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328233 C[C@@H]1N(C)c2nc(NCc3cnn(CC4CCC4)c3)nc(C)c2NC1=O InChI=1S/C18H25N7O/c1-11-15-16(24(3)12(2)17(26)22-15)23-18(21-11)19-7-14-8-20-25(10-14)9-13-5-4-6-13/h8,10,12-13H,4-7,9H2,1-3H3,(H,22,26)(H,19,21,23)/t12-/m0/s1 RTZQFFFORNPUSG-LBPRGKRZSA-N 622528 US20230312587, Compound 5 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622528&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195254 485229661 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328234 C[C@@H]1N(C)c2nc(NCc3cnn(CCc4ccc(F)cc4)c3)nc(C)c2NC1=O InChI=1S/C21H24FN7O/c1-13-18-19(28(3)14(2)20(30)26-18)27-21(25-13)23-10-16-11-24-29(12-16)9-8-15-4-6-17(22)7-5-15/h4-7,11-12,14H,8-10H2,1-3H3,(H,26,30)(H,23,25,27)/t14-/m0/s1 LTHWBTMZSKGYKY-AWEZNQCLSA-N 622529 US20230312587, Compound 6 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622529&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194860 485229662 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328235 C[C@@H]1N(C)c2nc(NCc3cnn(CC4CCC4)c3)nc(C)c2N(C)C1=O InChI=1S/C19H27N7O/c1-12-16-17(24(3)13(2)18(27)25(16)4)23-19(22-12)20-8-15-9-21-26(11-15)10-14-6-5-7-14/h9,11,13-14H,5-8,10H2,1-4H3,(H,20,22,23)/t13-/m0/s1 YFYRLMJLARLKRW-ZDUSSCGKSA-N 622530 US20230312587, Compound 7 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622530&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194721 485229663 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328236 C[C@@H]1N(C)c2nc(NCc3cnn(CCc4ccc(F)cc4)c3)nc(C)c2N(C)C1=O InChI=1S/C22H26FN7O/c1-14-19-20(28(3)15(2)21(31)29(19)4)27-22(26-14)24-11-17-12-25-30(13-17)10-9-16-5-7-18(23)8-6-16/h5-8,12-13,15H,9-11H2,1-4H3,(H,24,26,27)/t15-/m0/s1 LUGKUZWXEZXMSA-HNNXBMFYSA-N 622531 US20230312587, Compound 8 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622531&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195130 485229664 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328237 CC[C@@H]1N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc2NC1=O InChI=1S/C20H22FN7O/c1-3-17-19(29)25-16-10-23-20(26-18(16)27(17)2)22-8-14-9-24-28(12-14)11-13-4-6-15(21)7-5-13/h4-7,9-10,12,17H,3,8,11H2,1-2H3,(H,25,29)(H,22,23,26)/t17-/m0/s1 DNMUCGCXSOUGCA-KRWDZBQOSA-N 622532 US20230312587, Compound 9 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622532&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146199422 485229665 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328238 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4cc(F)c(F)c(F)c4)c3)nc(C)c2N(C)C1=O InChI=1S/C21H22F3N7O/c1-11-18-19(29(3)12(2)20(32)30(18)4)28-21(27-11)25-7-14-8-26-31(10-14)9-13-5-15(22)17(24)16(23)6-13/h5-6,8,10,12H,7,9H2,1-4H3,(H,25,27,28)/t12-/m0/s1 VXMQWLJQAJKXLI-LBPRGKRZSA-N 622533 (7S)-4,5,7,8-tetramethyl-2-(((1-(3,4,5-trifluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 14 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622533&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194381 485229666 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328239 CC[C@@H]1N(C)c2nc(NCc3cnn(Cc4cc(F)c(F)c(F)c4)c3)ncc2N(C)C1=O InChI=1S/C21H22F3N7O/c1-4-16-20(32)30(3)17-9-26-21(28-19(17)29(16)2)25-7-13-8-27-31(11-13)10-12-5-14(22)18(24)15(23)6-12/h5-6,8-9,11,16H,4,7,10H2,1-3H3,(H,25,26,28)/t16-/m0/s1 ARLBFQTZGJLZBT-INIZCTEOSA-N 622534 (7S)-7-Ethyl-5,8-dimethyl-2-(((1-(3,4,5-trifluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 15 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622534&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194505 485229667 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328240 CC[C@@H]1N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc2N(CC)C1=O InChI=1S/C22H26FN7O/c1-4-18-21(31)30(5-2)19-12-25-22(27-20(19)28(18)3)24-10-16-11-26-29(14-16)13-15-6-8-17(23)9-7-15/h6-9,11-12,14,18H,4-5,10,13H2,1-3H3,(H,24,25,27)/t18-/m0/s1 HBTWXLIVLUSQOF-SFHVURJKSA-N 622535 (7S)-5,7-Diethyl-2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-8-methyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 19 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622535&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194296 485229668 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328241 CCN1[C@@H](C)C(=O)N(C)c2cnc(NCc3cnn(Cc4ccc(F)cc4)c3)nc12 InChI=1S/C21H24FN7O/c1-4-29-14(2)20(30)27(3)18-11-24-21(26-19(18)29)23-9-16-10-25-28(13-16)12-15-5-7-17(22)8-6-15/h5-8,10-11,13-14H,4,9,12H2,1-3H3,(H,23,24,26)/t14-/m0/s1 PJUGQOQDZBNMHB-AWEZNQCLSA-N 622536 (7S)-8-ethyl-2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 22 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622536&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194611 485229669 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328242 CCCC1N(C)c2nc(NCc3cnn(Cc4cc(F)c(F)c(F)c4)c3)ncc2N(C)C1=O InChI=1S/C22H24F3N7O/c1-4-5-17-21(33)31(3)18-10-27-22(29-20(18)30(17)2)26-8-14-9-28-32(12-14)11-13-6-15(23)19(25)16(24)7-13/h6-7,9-10,12,17H,4-5,8,11H2,1-3H3,(H,26,27,29) YNWSIQWXDATULY-UHFFFAOYSA-N 622537 5,8-dimethyl-7-propyl-2-(((1-(3,4,5-trifluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 23 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622537&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194297 485229670 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328243 CCCC1N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc2N(C)C1=O InChI=1S/C22H26FN7O/c1-4-5-18-21(31)29(3)19-12-25-22(27-20(19)28(18)2)24-10-16-11-26-30(14-16)13-15-6-8-17(23)9-7-15/h6-9,11-12,14,18H,4-5,10,13H2,1-3H3,(H,24,25,27) IKEVYDBMRYAGJJ-UHFFFAOYSA-N 622538 2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-5,8-dimethyl-7-propyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 24 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622538&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194355 485229671 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328244 CCN1C(C)C(=O)N(CC)c2cnc(NCc3cnn(Cc4ccc(F)cc4)c3)nc12 InChI=1S/C22H26FN7O/c1-4-29-15(3)21(31)30(5-2)19-12-25-22(27-20(19)29)24-10-17-11-26-28(14-17)13-16-6-8-18(23)9-7-16/h6-9,11-12,14-15H,4-5,10,13H2,1-3H3,(H,24,25,27) FJHRUYAANFAWES-UHFFFAOYSA-N 622539 5,8-diethyl-2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7-methyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 30 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622539&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194010 485229672 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328245 CCC1N(C(C)C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc2N(C)C1=O InChI=1S/C23H28FN7O/c1-5-19-22(32)29(4)20-12-26-23(28-21(20)31(19)15(2)3)25-10-17-11-27-30(14-17)13-16-6-8-18(24)9-7-16/h6-9,11-12,14-15,19H,5,10,13H2,1-4H3,(H,25,26,28) PGBUZODXIQYDHF-UHFFFAOYSA-N 622540 (R)-7-ethyl-2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-8-isopropyl-5-methyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 32 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622540&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194714 485229673 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328246 CCN1C(=O)[C@](C)(CC)N(CC)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc12 InChI=1S/C24H30FN7O/c1-5-24(4)22(33)31(6-2)20-14-27-23(29-21(20)32(24)7-3)26-12-18-13-28-30(16-18)15-17-8-10-19(25)11-9-17/h8-11,13-14,16H,5-7,12,15H2,1-4H3,(H,26,27,29)/t24-/m0/s1 DZCIEYWOLNUECH-DEOSSOPVSA-N 622541 (7S)-5,7,8-triethyl-2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7-methyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 34 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622541&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194602 485229674 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328247 COc1c(F)cc(Cn2cc(CNc3ncc4NC(=O)[C@H](C)N(C)c4n3)cn2)cc1F InChI=1S/C20H21F2N7O2/c1-11-19(30)26-16-8-24-20(27-18(16)28(11)2)23-6-13-7-25-29(10-13)9-12-4-14(21)17(31-3)15(22)5-12/h4-5,7-8,10-11H,6,9H2,1-3H3,(H,26,30)(H,23,24,27)/t11-/m0/s1 HPMUTLMCWKABSF-NSHDSACASA-N 622542 (7S)-2-(((1-(3,5-difluoro-4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 44 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622542&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195230 485229675 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328248 COc1c(F)cc(Cn2cc(CNc3nc(C)c4NC(=O)[C@H](C)N(C)c4n3)cn2)cc1F InChI=1S/C21H23F2N7O2/c1-11-17-19(29(3)12(2)20(31)27-17)28-21(26-11)24-7-14-8-25-30(10-14)9-13-5-15(22)18(32-4)16(23)6-13/h5-6,8,10,12H,7,9H2,1-4H3,(H,27,31)(H,24,26,28)/t12-/m0/s1 AOPGRPZXPVBPEK-LBPRGKRZSA-N 622543 (7S)-2-(((1-(3,5-difluoro-4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 46 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622543&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194206 485229676 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328249 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4cccc(c4)C(F)(F)F)c3)nc(C)c2NC1=O InChI=1S/C21H22F3N7O/c1-12-17-18(30(3)13(2)19(32)28-17)29-20(27-12)25-8-15-9-26-31(11-15)10-14-5-4-6-16(7-14)21(22,23)24/h4-7,9,11,13H,8,10H2,1-3H3,(H,28,32)(H,25,27,29)/t13-/m0/s1 QLMGKECOJDBCSO-ZDUSSCGKSA-N 622544 (7S)-4,7,8-trimethyl-2-(((1-(3-(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 47 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622544&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194137 485229677 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328250 CCN1[C@@H](CCO)C(=O)N(CC)c2cnc(NCc3cnn(Cc4cc(F)c(OC)c(F)c4)c3)nc12 InChI=1S/C24H29F2N7O3/c1-4-32-19(6-7-34)23(35)33(5-2)20-12-28-24(30-22(20)32)27-10-16-11-29-31(14-16)13-15-8-17(25)21(36-3)18(26)9-15/h8-9,11-12,14,19,34H,4-7,10,13H2,1-3H3,(H,27,28,30)/t19-/m0/s1 CCAPEBQULINXFU-IBGZPJMESA-N 622545 (7S)-2-(((1-(3,5-difluoro-4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)amino)-5,8-diethyl-7-(2-hydroxyethyl)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 48 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622545&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194683 485229678 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328251 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4cc(F)c(O)c(F)c4)c3)ncc2NC1=O InChI=1S/C19H19F2N7O2/c1-10-18(30)25-15-7-23-19(26-17(15)27(10)2)22-5-12-6-24-28(9-12)8-11-3-13(20)16(29)14(21)4-11/h3-4,6-7,9-10,29H,5,8H2,1-2H3,(H,25,30)(H,22,23,26)/t10-/m0/s1 HQRSTYZEPQOPGW-JTQLQIEISA-N 622546 (7S)-2-(((1-(3,5-difluoro-4-hydroxybenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 50 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622546&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146193975 485229679 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328252 CCN1C(=O)[C@H](C)N(C(C)C)c2nc(NCc3cnn(Cc4cc(F)c(F)c(F)c4)c3)ncc12 InChI=1S/C23H26F3N7O/c1-5-32-19-10-28-23(30-21(19)33(13(2)3)14(4)22(32)34)27-8-16-9-29-31(12-16)11-15-6-17(24)20(26)18(25)7-15/h6-7,9-10,12-14H,5,8,11H2,1-4H3,(H,27,28,30)/t14-/m0/s1 UQFGPDOBSXZOBD-AWEZNQCLSA-N 622547 (7S)-5-ethyl-8-isopropyl-7-methyl-2-(((1-(3,4,5-trifluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 51 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622547&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195282 485229680 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328253 C[C@@H]1N(C)c2nc(NCc3ccc(Oc4ccc(F)cc4)nc3)nc(C)c2NC1=O InChI=1S/C21H21FN6O2/c1-12-18-19(28(3)13(2)20(29)26-18)27-21(25-12)24-11-14-4-9-17(23-10-14)30-16-7-5-15(22)6-8-16/h4-10,13H,11H2,1-3H3,(H,26,29)(H,24,25,27)/t13-/m0/s1 MJGJMSYCHYEMDI-ZDUSSCGKSA-N 622548 (7S)-2-(((6-(4-fluorophenoxy)pyridin-3-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 54 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622548&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195237 485229681 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328254 C[C@@H]1N(C)c2nc(NCc3cnn(c3)[C@H]3C[C@@H](C3)c3ccc(F)cc3)nc(C)c2NC1=O InChI=1S/C23H26FN7O/c1-13-20-21(30(3)14(2)22(32)28-20)29-23(27-13)25-10-15-11-26-31(12-15)19-8-17(9-19)16-4-6-18(24)7-5-16/h4-7,11-12,14,17,19H,8-10H2,1-3H3,(H,28,32)(H,25,27,29)/t14-,17-,19-/m0/s1 XSIKBIVCYSIVSI-FNHZYXHNSA-N 622549 (7S)-2-(((trans-1-(3-(4-fluorophenyl)cyclobutyl)-1H-pyrazol-4-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 112 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622549&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194357 485229682 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328255 C[C@@H]1N(C)c2nc(NCc3cnn(CCC4CCCCC4)c3)nc(C)c2NC1=O InChI=1S/C21H31N7O/c1-14-18-19(27(3)15(2)20(29)25-18)26-21(24-14)22-11-17-12-23-28(13-17)10-9-16-7-5-4-6-8-16/h12-13,15-16H,4-11H2,1-3H3,(H,25,29)(H,22,24,26)/t15-/m0/s1 DMOVAVNTCMRPLQ-HNNXBMFYSA-N 622550 (7S)-2-(((1-(2-cyclohexylethyl)-1H-pyrazol-4-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 113 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622550&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195295 485229683 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328256 C[C@@H]1N(C)c2nc(NCc3cnn(c3)C3Cc4ccccc4C3)nc(C)c2NC1=O InChI=1S/C22H25N7O/c1-13-19-20(28(3)14(2)21(30)26-19)27-22(25-13)23-10-15-11-24-29(12-15)18-8-16-6-4-5-7-17(16)9-18/h4-7,11-12,14,18H,8-10H2,1-3H3,(H,26,30)(H,23,25,27)/t14-/m0/s1 SDPCSOBYLJDZGD-AWEZNQCLSA-N 622551 (7S)-2-(((1-(2,3-dihydro-1H-inden-2-yl)-1H-pyrazol-4-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 116 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622551&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194766 485229684 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328257 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4ccc(nc4)C(F)(F)F)c3)nc(C)c2NC1=O InChI=1S/C20H21F3N8O/c1-11-16-17(30(3)12(2)18(32)28-16)29-19(27-11)25-7-14-8-26-31(10-14)9-13-4-5-15(24-6-13)20(21,22)23/h4-6,8,10,12H,7,9H2,1-3H3,(H,28,32)(H,25,27,29)/t12-/m0/s1 KKHCZENFFDIZHM-LBPRGKRZSA-N 622552 (7S)-4,7,8-trimethyl-2-(((1-((6-(trifluoromethyl)pyridin-3-yl)methyl)-111-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 136 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622552&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194099 485229685 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328258 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4c(C)noc4C)c3)nc(C)c2NC1=O InChI=1S/C19H24N8O2/c1-10-15(13(4)29-25-10)9-27-8-14(7-21-27)6-20-19-22-11(2)16-17(24-19)26(5)12(3)18(28)23-16/h7-8,12H,6,9H2,1-5H3,(H,23,28)(H,20,22,24)/t12-/m0/s1 IFUZYIPZTLMSBK-LBPRGKRZSA-N 622553 (7S)-2-(((1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)methyl)amino)-4,7,8-trimethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 138 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622553&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195246 485229686 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328259 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4cc(nn4C)C(F)(F)F)c3)nc(C)c2NC1=O InChI=1S/C19H22F3N9O/c1-10-15-16(29(3)11(2)17(32)26-15)27-18(25-10)23-6-12-7-24-31(8-12)9-13-5-14(19(20,21)22)28-30(13)4/h5,7-8,11H,6,9H2,1-4H3,(H,26,32)(H,23,25,27)/t11-/m0/s1 RBGPMMVTXKPIHO-NSHDSACASA-N 622554 (7S)-4,7,8-trimethyl-2-(((1-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 160 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622554&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194438 485229687 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328260 C[C@@H]1N(C)c2nc(NCc3cnn(Cc4ccc(o4)C(F)(F)F)c3)nc(C)c2NC1=O InChI=1S/C19H20F3N7O2/c1-10-15-16(28(3)11(2)17(30)26-15)27-18(25-10)23-6-12-7-24-29(8-12)9-13-4-5-14(31-13)19(20,21)22/h4-5,7-8,11H,6,9H2,1-3H3,(H,26,30)(H,23,25,27)/t11-/m0/s1 NKLJEEKVVMPIHL-NSHDSACASA-N 622555 (7S)-4,7,8-trimethyl-2-(((1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 192 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622555&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194826 485229688 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328261 CN1c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)nc(C)c2NC(=O)C11CC1 InChI=1S/C21H22FN7O/c1-13-17-18(28(2)21(7-8-21)19(30)26-17)27-20(25-13)23-9-15-10-24-29(12-15)11-14-3-5-16(22)6-4-14/h3-6,10,12H,7-9,11H2,1-2H3,(H,26,30)(H,23,25,27) BNCDRIZDRHKXGT-UHFFFAOYSA-N 622556 2′-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-4′,8′-dimethyl-5′,8′-dihydro-6′H-spiro[cyclopropane-1,7′-pteridin]-6′-on::US20230312587, Compound 221 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622556&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194873 485229689 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328262 CN1C(=O)C2(CC2)N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)nc(C)c12 InChI=1S/C22H24FN7O/c1-14-18-19(29(3)22(8-9-22)20(31)28(18)2)27-21(26-14)24-10-16-11-25-30(13-16)12-15-4-6-17(23)7-5-15/h4-7,11,13H,8-10,12H2,1-3H3,(H,24,26,27) FQFDEOGSJKJJJA-UHFFFAOYSA-N 622557 2′-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-4′,5′,8′-trimethyl-5′,8′-dihydro-6′H-spiro[cyclopropane-1,7′-pteridin]-6′-one::US20230312587, Compound 223 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622557&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194818 485229690 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328263 CN1C(=O)C(C)(C)N(C)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc12 InChI=1S/C21H24FN7O/c1-21(2)19(30)27(3)17-11-24-20(26-18(17)28(21)4)23-9-15-10-25-29(13-15)12-14-5-7-16(22)8-6-14/h5-8,10-11,13H,9,12H2,1-4H3,(H,23,24,26) AABFNJHWMYLKKG-UHFFFAOYSA-N 622558 2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-5,7,7,8-tetramethyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 224 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622558&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194067 485229691 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328264 CN1C(=O)C(C)(C)N(C)c2nc(NCc3cnn(Cc4cc(F)c(F)c(F)c4)c3)ncc12 InChI=1S/C21H22F3N7O/c1-21(2)19(32)29(3)16-9-26-20(28-18(16)30(21)4)25-7-13-8-27-31(11-13)10-12-5-14(22)17(24)15(23)6-12/h5-6,8-9,11H,7,10H2,1-4H3,(H,25,26,28) PKVPQMALOCSOGK-UHFFFAOYSA-N 622559 5,7,7,8-tetramethyl-2-(((1-(3,4,5-trifluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 229 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622559&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194455 485229692 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328265 CCN1C(=O)[C@@](C)(CC)N(CC)c2nc(NCc3cnn(Cc4ccc(F)cc4)c3)ncc12 InChI=1S/C24H30FN7O/c1-5-24(4)22(33)31(6-2)20-14-27-23(29-21(20)32(24)7-3)26-12-18-13-28-30(16-18)15-17-8-10-19(25)11-9-17/h8-11,13-14,16H,5-7,12,15H2,1-4H3,(H,26,27,29)/t24-/m1/s1 DZCIEYWOLNUECH-XMMPIXPASA-N 622560 (7R)-5,7,8-triethyl-2-(((1-(4-fluorobenzyl)-1H-pyrazol-4-yl)methyl)amino)-7-methyl-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 234 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622560&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195122 485229693 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328266 C[C@@H]1N(C)c2nc(N[C@H]3C[C@@H](C3)Oc3cc(F)c(F)c(F)c3)nc(C)c2NC1=O InChI=1S/C19H20F3N5O2/c1-8-16-17(27(3)9(2)18(28)25-16)26-19(23-8)24-10-4-11(5-10)29-12-6-13(20)15(22)14(21)7-12/h6-7,9-11H,4-5H2,1-3H3,(H,25,28)(H,23,24,26)/t9-,10-,11-/m0/s1 AVRVUNXZGSYHGN-DCAQKATOSA-N 622561 (7S)-4,7,8-trimethyl-2-((trans-3-(3,4,5-trifluorophenoxy)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 246 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622561&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195070 485229694 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328267 C[C@@H]1N(C)c2nc(N[C@H]3C[C@H](C3)Oc3cc(F)c(F)c(F)c3)nc(C)c2NC1=O InChI=1S/C19H20F3N5O2/c1-8-16-17(27(3)9(2)18(28)25-16)26-19(23-8)24-10-4-11(5-10)29-12-6-13(20)15(22)14(21)7-12/h6-7,9-11H,4-5H2,1-3H3,(H,25,28)(H,23,24,26)/t9-,10-,11+/m0/s1 AVRVUNXZGSYHGN-GARJFASQSA-N 622562 (7S)-4,7,8-trimethyl-2-((cis-3-(3,4,5-trifluorophenoxy)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 247 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622562&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195070 485229695 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328268 C[C@@H]1N(C)c2nc(N[C@H]3C[C@@H](C3)Oc3cc(F)c(F)c(F)c3)nc(C)c2N(C)C1=O InChI=1S/C20H22F3N5O2/c1-9-17-18(27(3)10(2)19(29)28(17)4)26-20(24-9)25-11-5-12(6-11)30-13-7-14(21)16(23)15(22)8-13/h7-8,10-12H,5-6H2,1-4H3,(H,24,25,26)/t10-,11-,12-/m0/s1 KHPZCUPEAUDPTN-SRVKXCTJSA-N 622563 (7S)-4,5,7,8-tetramethyl-2-((trans-3-(3,4,5-trifluorophenoxy)cyclobutyl)-amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 253 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622563&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194571 485229696 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328269 C[C@@H]1N(C)c2nc(N[C@H]3C[C@@H](C3)OCc3cc(F)c(F)c(F)c3)nc(C)c2NC1=O InChI=1S/C20H22F3N5O2/c1-9-17-18(28(3)10(2)19(29)26-17)27-20(24-9)25-12-6-13(7-12)30-8-11-4-14(21)16(23)15(22)5-11/h4-5,10,12-13H,6-8H2,1-3H3,(H,26,29)(H,24,25,27)/t10-,12-,13-/m0/s1 JYSQAQVKKHGAFR-DRZSPHRISA-N 622564 (7S)-4,7,8-trimethyl-2-((trans-3-((3,4,5-trifluorobenzyl)oxy)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 254 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622564&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194432 485229697 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328270 C[C@@H]1N(C)c2nc(N[C@@H]3CC[C@H](C3)Oc3cc(F)c(F)c(F)c3)nc(C)c2NC1=O InChI=1S/C20H22F3N5O2/c1-9-17-18(28(3)10(2)19(29)26-17)27-20(24-9)25-11-4-5-12(6-11)30-13-7-14(21)16(23)15(22)8-13/h7-8,10-12H,4-6H2,1-3H3,(H,26,29)(H,24,25,27)/t10-,11+,12+/m0/s1 MJQBNYAFCPMAJM-QJPTWQEYSA-N 622565 (S)-4,7,8-trimethyl-2-(((1R,3R)-3-(3,4,5-trifluorophenoxy)cyclopentyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 267 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622565&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195411 485229698 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328271 C[C@@H]1N(C)c2nc(N[C@H]3CC[C@@H](C3)Oc3cc(F)c(F)c(F)c3)nc(C)c2NC1=O InChI=1S/C20H22F3N5O2/c1-9-17-18(28(3)10(2)19(29)26-17)27-20(24-9)25-11-4-5-12(6-11)30-13-7-14(21)16(23)15(22)8-13/h7-8,10-12H,4-6H2,1-3H3,(H,26,29)(H,24,25,27)/t10-,11-,12-/m0/s1 MJQBNYAFCPMAJM-SRVKXCTJSA-N 622566 (S)-4,7,8-trimethyl-2-(((1S,3S)-3-(3,4,5-trifluorophenoxy)cyclopentyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 268 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622566&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194226 485229699 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328272 C[C@@H]1N(C)c2nc(N[C@@H]3C[C@H](Cn4nccc4C(F)(F)F)C3)nc(C)c2NC1=O InChI=1S/C18H22F3N7O/c1-9-14-15(27(3)10(2)16(29)25-14)26-17(23-9)24-12-6-11(7-12)8-28-13(4-5-22-28)18(19,20)21/h4-5,10-12H,6-8H2,1-3H3,(H,25,29)(H,23,24,26)/t10-,11-,12+/m0/s1 BUVHAXVKOBMPIT-SDDRHHMPSA-N 622567 (7S)-4,7,8-trimethyl-2-((cis-3-((5-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 275 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622567&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195055 485229700 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328273 C[C@@H]1N(C)c2nc(N[C@@H]3CC[C@H](C3)n3ccc(n3)C(F)(F)F)nc(C)c2NC1=O InChI=1S/C18H22F3N7O/c1-9-14-15(27(3)10(2)16(29)24-14)25-17(22-9)23-11-4-5-12(8-11)28-7-6-13(26-28)18(19,20)21/h6-7,10-12H,4-5,8H2,1-3H3,(H,24,29)(H,22,23,25)/t10-,11+,12+/m0/s1 RGMOVIJXLHBOJU-QJPTWQEYSA-N 622568 (7S)-4,7,8-trimethyl-2-(((1R,3R)-3-(3-(trifluoromethyl)-1H-pyrazol-1-yl)cyclopentyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 311 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622568&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146194715 485229701 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1328274 C[C@@H]1N(C)c2nc(N[C@H]3C[C@@H](C3)Oc3ccnc(c3)C(F)(F)F)nc(C)c2NC1=O InChI=1S/C19H21F3N6O2/c1-9-15-16(28(3)10(2)17(29)26-15)27-18(24-9)25-11-6-13(7-11)30-12-4-5-23-14(8-12)19(20,21)22/h4-5,8,10-11,13H,6-7H2,1-3H3,(H,26,29)(H,24,25,27)/t10-,11-,13-/m0/s1 ZJYDBFUWMIBVIX-GVXVVHGQSA-N 622569 (7S)-4,7,8-trimethyl-2-((trans-3-((2-(trifluoromethyl)pyridin-4-yl)oxy)cyclobutyl)amino)-7,8-dihydropteridin-6(5H)-one::US20230312587, Compound 335 Serine/threonine-protein kinase PLK1 Homo sapiens >4000 US Patent 10.7270/Q24J0K80 US20230312587 LAUFFER, D; Bemis, G; Boyd, M; Deininger, D; Deng, H; Dorsch, W; Gu, W; Hoover, RR; Johnson, JR., MA; Ledeboer, MW; Ledford, B; Maltais, F; Penney, M; Takemoto, D; Waal, ND; Wang, T; Li, P Vertex Pharmaceutical Incorporated http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=622569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=622569&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 146195262 485229702 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51502656 COc1ncc2cc3cnccc3c([N+]([O-])=O)c2n1 InChI=1S/C12H8N4O3/c1-19-12-14-6-8-4-7-5-13-3-2-9(7)11(16(17)18)10(8)15-12/h2-6H,1H3 WPPGBVWZGMDXKF-UHFFFAOYSA-N 50605471 CHEMBL5181620 Serine/threonine-protein kinase PLK1 Homo sapiens 294 ChEMBL 10.7270/Q2HQ440P 35447555 Zeinyeh, W; Esvan, YJ; Josselin, B; Defois, M; Baratte, B; Knapp, S; Chaikuad, A; Anizon, F; Giraud, F; Ruchaud, S; Moreau, P Universit£ Clermont Auvergne http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605471&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 163322354 482616322 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528330 COc1ccccc1-n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc4c(CN(C)CC4(C)C)c3)ncc2c1=O InChI=1S/C32H35N7O3/c1-31(2)19-37(5)18-20-16-21(14-15-23(20)31)34-30-33-17-22-28(36-30)39(27-13-9-12-26(35-27)32(3,4)41)38(29(22)40)24-10-7-8-11-25(24)42-6/h7-17,41H,18-19H2,1-6H3,(H,33,34,36) KEQAEPQFWOQEKT-UHFFFAOYSA-N 50615024 CHEMBL5291362 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615024&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171351989 494504772 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528331 COc1ccccc1-n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc4c(CNCC4(C)C)c3)ncc2c1=O InChI=1S/C31H33N7O3/c1-30(2)18-32-16-19-15-20(13-14-22(19)30)34-29-33-17-21-27(36-29)38(26-12-8-11-25(35-26)31(3,4)40)37(28(21)39)23-9-6-7-10-24(23)41-5/h6-15,17,32,40H,16,18H2,1-5H3,(H,33,34,36) NGQGJGXHPKUCEQ-UHFFFAOYSA-N 50615025 CHEMBL5269631 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615025&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171343141 494504773 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528332 COc1ccccc1-n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc4CCN(C)Cc4c3)ncc2c1=O InChI=1S/C30H31N7O3/c1-30(2,39)25-10-7-11-26(33-25)37-27-22(28(38)36(37)23-8-5-6-9-24(23)40-4)17-31-29(34-27)32-21-13-12-19-14-15-35(3)18-20(19)16-21/h5-13,16-17,39H,14-15,18H2,1-4H3,(H,31,32,34) DYQAJCMBCBEEHH-UHFFFAOYSA-N 50615026 CHEMBL5286202 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615026&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171347469 494504774 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528333 COc1ccccc1-n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O InChI=1S/C32H35N7O3/c1-32(2,41)27-10-7-11-28(35-27)39-29-24(30(40)38(39)25-8-5-6-9-26(25)42-4)20-33-31(36-29)34-23-14-12-21(13-15-23)22-16-18-37(3)19-17-22/h5-15,20,22,41H,16-19H2,1-4H3,(H,33,34,36) AYFGNXVCSIXEDG-UHFFFAOYSA-N 50615027 CHEMBL5286494 Serine/threonine-protein kinase PLK1 Homo sapiens 7700 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615027&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171346193 494504775 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528334 CC(C)(O)c1cccc(n1)-n1n(-c2ccccc2F)c(=O)c2cnc(Nc3ccc4c(NCCC4(C)C)c3)nc12 InChI=1S/C30H30FN7O2/c1-29(2)14-15-32-22-16-18(12-13-20(22)29)34-28-33-17-19-26(36-28)38(25-11-7-10-24(35-25)30(3,4)40)37(27(19)39)23-9-6-5-8-21(23)31/h5-13,16-17,32,40H,14-15H2,1-4H3,(H,33,34,36) WKQISFYCALGCGD-UHFFFAOYSA-N 50615028 CHEMBL5285865 Serine/threonine-protein kinase PLK1 Homo sapiens 5400 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615028&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171348662 494504776 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528335 CN1CCC(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C2CCCC2)c3=O)cc1 InChI=1S/C30H37N7O2/c1-30(2,39)25-9-6-10-26(33-25)37-27-24(28(38)36(37)23-7-4-5-8-23)19-31-29(34-27)32-22-13-11-20(12-14-22)21-15-17-35(3)18-16-21/h6,9-14,19,21,23,39H,4-5,7-8,15-18H2,1-3H3,(H,31,32,34) DGXWMXHFEWCJTP-UHFFFAOYSA-N 50615029 CHEMBL5272346 Serine/threonine-protein kinase PLK1 Homo sapiens 3641 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615029&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171345179 494504777 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528336 CN1CCc2ccc(Nc3ncc4c(n3)n(-c3cccc(n3)C(C)(C)O)n(C3CCCC=C3)c4=O)cc2C1 InChI=1S/C29H33N7O2/c1-29(2,38)24-10-7-11-25(32-24)36-26-23(27(37)35(36)22-8-5-4-6-9-22)17-30-28(33-26)31-21-13-12-19-14-15-34(3)18-20(19)16-21/h5,7-8,10-13,16-17,22,38H,4,6,9,14-15,18H2,1-3H3,(H,30,31,33) VOWKUHQZSGCZFU-UHFFFAOYSA-N 50615030 CHEMBL5286243 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615030&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171348319 494504778 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528337 CN1CCC(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C2CCCC=C2)c3=O)cc1 InChI=1S/C31H37N7O2/c1-31(2,40)26-10-7-11-27(34-26)38-28-25(29(39)37(38)24-8-5-4-6-9-24)20-32-30(35-28)33-23-14-12-21(13-15-23)22-16-18-36(3)19-17-22/h5,7-8,10-15,20,22,24,40H,4,6,9,16-19H2,1-3H3,(H,32,33,35) AVRXPWHNFRJKJJ-UHFFFAOYSA-N 50615031 CHEMBL5281815 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615031&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171356703 494504779 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528338 CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C2CCCC=C2)c3=O)cc1 InChI=1S/C32H40N8O2/c1-32(2,42)27-11-8-12-28(35-27)40-29-26(30(41)39(40)25-9-6-5-7-10-25)21-33-31(36-29)34-22-13-15-24(16-14-22)38-19-17-23(18-20-38)37(3)4/h6,8-9,11-16,21,23,25,42H,5,7,10,17-20H2,1-4H3,(H,33,34,36) AGULKNIKZOLEFC-UHFFFAOYSA-N 50615032 CHEMBL5268938 Serine/threonine-protein kinase PLK1 Homo sapiens 5400 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615032&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171343836 494504780 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528339 CN1CCc2cc(Nc3ncc4c(n3)n(-c3cccc(n3)C(C)(C)O)n(C3CCCC=C3)c4=O)ccc2C1 InChI=1S/C29H33N7O2/c1-29(2,38)24-10-7-11-25(32-24)36-26-23(27(37)35(36)22-8-5-4-6-9-22)17-30-28(33-26)31-21-13-12-20-18-34(3)15-14-19(20)16-21/h5,7-8,10-13,16-17,22,38H,4,6,9,14-15,18H2,1-3H3,(H,30,31,33) NHBSXIGAYOREOT-UHFFFAOYSA-N 50615033 CHEMBL5269511 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615033&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171342987 494504781 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528340 CC(C)(O)c1cccc(n1)-n1n(C2CCCC=C2)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CCO)CC3)nc12 InChI=1S/C31H38N8O3/c1-31(2,42)26-9-6-10-27(34-26)39-28-25(29(41)38(39)24-7-4-3-5-8-24)21-32-30(35-28)33-22-11-13-23(14-12-22)37-17-15-36(16-18-37)19-20-40/h4,6-7,9-14,21,24,40,42H,3,5,8,15-20H2,1-2H3,(H,32,33,35) YSDIMXIZMBRTHQ-UHFFFAOYSA-N 50615034 CHEMBL5288130 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615034&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171351509 494504782 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528341 CN1Cc2ccc(Nc3ncc4c(n3)n(-c3cccc(n3)C(C)(C)O)n(C3CCCC=C3)c4=O)cc2C1 InChI=1S/C28H31N7O2/c1-28(2,37)23-10-7-11-24(31-23)35-25-22(26(36)34(35)21-8-5-4-6-9-21)15-29-27(32-25)30-20-13-12-18-16-33(3)17-19(18)14-20/h5,7-8,10-15,21,37H,4,6,9,16-17H2,1-3H3,(H,29,30,32) OLLXANSJPNHXRT-UHFFFAOYSA-N 50615035 CHEMBL5291431 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615035&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171351835 494504783 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528342 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n([C@H]2CCCC=C2)c3=O)cc1 InChI=1S/C30H36N8O2/c1-30(2,40)25-10-7-11-26(33-25)38-27-24(28(39)37(38)23-8-5-4-6-9-23)20-31-29(34-27)32-21-12-14-22(15-13-21)36-18-16-35(3)17-19-36/h5,7-8,10-15,20,23,40H,4,6,9,16-19H2,1-3H3,(H,31,32,34)/t23-/m1/s1 JJEGWIJBJXWVDU-HSZRJFAPSA-N 50615036 CHEMBL5269559 Serine/threonine-protein kinase PLK1 Homo sapiens 5831 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615036&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171342284 494504784 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528343 CN1CCc2ccc(Nc3ncc4c(n3)n(-c3cccc(C)n3)n(CC=C)c4=O)cc2C1 InChI=1S/C24H25N7O/c1-4-11-30-23(32)20-14-25-24(28-22(20)31(30)21-7-5-6-16(2)26-21)27-19-9-8-17-10-12-29(3)15-18(17)13-19/h4-9,13-14H,1,10-12,15H2,2-3H3,(H,25,27,28) DWMIWRHTHVFLTQ-UHFFFAOYSA-N 50615037 CHEMBL5285844 Serine/threonine-protein kinase PLK1 Homo sapiens 2100 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615037&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171348302 494504785 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528344 CN1CCc2ccc(Nc3ncc4c(n3)n(-c3cccc(n3)C(F)(F)F)n(CC=C)c4=O)cc2C1 InChI=1S/C24H22F3N7O/c1-3-10-33-22(35)18-13-28-23(29-17-8-7-15-9-11-32(2)14-16(15)12-17)31-21(18)34(33)20-6-4-5-19(30-20)24(25,26)27/h3-8,12-13H,1,9-11,14H2,2H3,(H,28,29,31) RAVOWWGMSYDIEV-UHFFFAOYSA-N 50615038 CHEMBL5267993 Serine/threonine-protein kinase PLK1 Homo sapiens 10000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615038&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171344709 494504786 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528345 CN1Cc2cc(Nc3ncc4c(n3)n(-c3cccc(n3)C(C)(C)O)n(CC=C)c4=O)ccc2C(C)(C)C1 InChI=1S/C28H33N7O2/c1-7-13-34-25(36)20-15-29-26(30-19-11-12-21-18(14-19)16-33(6)17-27(21,2)3)32-24(20)35(34)23-10-8-9-22(31-23)28(4,5)37/h7-12,14-15,37H,1,13,16-17H2,2-6H3,(H,29,30,32) DDEWQOWVNDYQSR-UHFFFAOYSA-N 518537 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one::US11124518, Example 12::US11299493, Compound 1.5 Serine/threonine-protein kinase PLK1 Homo sapiens 2100 ChEMBL 10.7270/Q2Z89HN6 37197456 Guler, S; DiPoto, MC; Crespo, A; Caldwell, R; Doerfel, B; Grossmann, N; Ho, K; Huck, B; Jones, CC; Lan, R; Musil, D; Potnick, J; Schilke, H; Sherer, B; Simon, S; Sirrenberg, C; Zhang, Z; Liu-Bujalski, L Emd Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518537&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137471929 461604553 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528346 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc4c(CNCC4(C)C)c3)nc12 InChI=1S/C27H31N7O2/c1-6-12-33-24(35)19-15-29-25(30-18-10-11-20-17(13-18)14-28-16-26(20,2)3)32-23(19)34(33)22-9-7-8-21(31-22)27(4,5)36/h6-11,13,15,28,36H,1,12,14,16H2,2-5H3,(H,29,30,32) WOBLPQMIMKNCIR-UHFFFAOYSA-N 518536 2-Allyl-6-((4,4-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one hydrochloride::US11124518, Example 11::US11299493, Compound 1.4 Serine/threonine-protein kinase PLK1 Homo sapiens 2300 ChEMBL 10.7270/Q2Z89HN6 37197456 Guler, S; DiPoto, MC; Crespo, A; Caldwell, R; Doerfel, B; Grossmann, N; Ho, K; Huck, B; Jones, CC; Lan, R; Musil, D; Potnick, J; Schilke, H; Sherer, B; Simon, S; Sirrenberg, C; Zhang, Z; Liu-Bujalski, L Emd Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518536&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137471984 461604552 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528347 CN1CCC(C)(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1 InChI=1S/C29H35N7O2/c1-6-16-35-26(37)22-19-30-27(33-25(22)36(35)24-9-7-8-23(32-24)28(2,3)38)31-21-12-10-20(11-13-21)29(4)14-17-34(5)18-15-29/h6-13,19,38H,1,14-18H2,2-5H3,(H,30,31,33) YFIFDFGPNQFIOE-UHFFFAOYSA-N 50615039 CHEMBL5280668 Serine/threonine-protein kinase PLK1 Homo sapiens 2749 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615039&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171353422 494504787 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528348 C\C=C\n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc(CN4CCOCC4)cc3)ncc2c1=O InChI=1S/C27H31N7O3/c1-4-12-33-25(35)21-17-28-26(29-20-10-8-19(9-11-20)18-32-13-15-37-16-14-32)31-24(21)34(33)23-7-5-6-22(30-23)27(2,3)36/h4-12,17,36H,13-16,18H2,1-3H3,(H,28,29,31)/b12-4+ XGBGLGGARORZSJ-UUILKARUSA-N 50615040 CHEMBL5289015 Serine/threonine-protein kinase PLK1 Homo sapiens 3633 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615040&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171351095 494504788 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528349 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2cccc(OC(F)(F)F)c2)c3=O)cc1 InChI=1S/C31H31F3N8O3/c1-30(2,44)25-8-5-9-26(37-25)42-27-24(28(43)41(42)22-6-4-7-23(18-22)45-31(32,33)34)19-35-29(38-27)36-20-10-12-21(13-11-20)40-16-14-39(3)15-17-40/h4-13,18-19,44H,14-17H2,1-3H3,(H,35,36,38) QLHZJXOMHSBCGL-UHFFFAOYSA-N 50615041 CHEMBL5277833 Serine/threonine-protein kinase PLK1 Homo sapiens 42 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615041&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171355567 494504789 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528350 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2cccc(c2)C#N)c3=O)cc1 InChI=1S/C31H31N9O2/c1-31(2,42)26-8-5-9-27(35-26)40-28-25(29(41)39(40)24-7-4-6-21(18-24)19-32)20-33-30(36-28)34-22-10-12-23(13-11-22)38-16-14-37(3)15-17-38/h4-13,18,20,42H,14-17H2,1-3H3,(H,33,34,36) GVDVAUYHYBSFNF-UHFFFAOYSA-N 50615042 CHEMBL5273365 Serine/threonine-protein kinase PLK1 Homo sapiens 110 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615042&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171349125 494504790 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528351 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2cccc(Cl)c2)c3=O)cc1 InChI=1S/C30H31ClN8O2/c1-30(2,41)25-8-5-9-26(34-25)39-27-24(28(40)38(39)23-7-4-6-20(31)18-23)19-32-29(35-27)33-21-10-12-22(13-11-21)37-16-14-36(3)15-17-37/h4-13,18-19,41H,14-17H2,1-3H3,(H,32,33,35) HJPSFWPXHJNVGU-UHFFFAOYSA-N 50615043 CHEMBL5269582 Serine/threonine-protein kinase PLK1 Homo sapiens 89 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615043&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171342701 494504791 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528352 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2cccc(C)c2)c3=O)cc1 InChI=1S/C31H34N8O2/c1-21-7-5-8-24(19-21)38-29(40)25-20-32-30(33-22-11-13-23(14-12-22)37-17-15-36(4)16-18-37)35-28(25)39(38)27-10-6-9-26(34-27)31(2,3)41/h5-14,19-20,41H,15-18H2,1-4H3,(H,32,33,35) JAWYXFZJQSZEGT-UHFFFAOYSA-N 50615044 CHEMBL5280254 Serine/threonine-protein kinase PLK1 Homo sapiens 1700 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615044&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171357889 494504792 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528353 COc1ccccc1-n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O InChI=1S/C31H34N8O3/c1-31(2,41)26-10-7-11-27(34-26)39-28-23(29(40)38(39)24-8-5-6-9-25(24)42-4)20-32-30(35-28)33-21-12-14-22(15-13-21)37-18-16-36(3)17-19-37/h5-15,20,41H,16-19H2,1-4H3,(H,32,33,35) YRSUINBEIRGTSA-UHFFFAOYSA-N 50615045 CHEMBL5274503 Serine/threonine-protein kinase PLK1 Homo sapiens 4347 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615045&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 168266208 494504793 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528354 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2ccccc2F)c3=O)cc1 InChI=1S/C30H31FN8O2/c1-30(2,41)25-9-6-10-26(34-25)39-27-22(28(40)38(39)24-8-5-4-7-23(24)31)19-32-29(35-27)33-20-11-13-21(14-12-20)37-17-15-36(3)16-18-37/h4-14,19,41H,15-18H2,1-3H3,(H,32,33,35) CYDYWAYVIILVQJ-UHFFFAOYSA-N 50615046 CHEMBL5289001 Serine/threonine-protein kinase PLK1 Homo sapiens 160 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615046&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171350933 494504794 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528355 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2ccccc2C)c3=O)cc1 InChI=1S/C31H34N8O2/c1-21-8-5-6-9-25(21)38-29(40)24-20-32-30(33-22-12-14-23(15-13-22)37-18-16-36(4)17-19-37)35-28(24)39(38)27-11-7-10-26(34-27)31(2,3)41/h5-15,20,41H,16-19H2,1-4H3,(H,32,33,35) QVIPCVQEBXPHAI-UHFFFAOYSA-N 50615047 CHEMBL5276665 Serine/threonine-protein kinase PLK1 Homo sapiens 1800 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615047&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171357688 494504795 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528356 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2ccccn2)c3=O)cc1 InChI=1S/C29H31N9O2/c1-29(2,40)23-7-6-9-25(33-23)37-26-22(27(39)38(37)24-8-4-5-14-30-24)19-31-28(34-26)32-20-10-12-21(13-11-20)36-17-15-35(3)16-18-36/h4-14,19,40H,15-18H2,1-3H3,(H,31,32,34) GLVMCPYFBLZASU-UHFFFAOYSA-N 50615048 CHEMBL5265766 Serine/threonine-protein kinase PLK1 Homo sapiens 4800 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615048&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171349414 494504796 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528357 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(-c2ccccc2)c3=O)cc1 InChI=1S/C30H32N8O2/c1-30(2,40)25-10-7-11-26(33-25)38-27-24(28(39)37(38)23-8-5-4-6-9-23)20-31-29(34-27)32-21-12-14-22(15-13-21)36-18-16-35(3)17-19-36/h4-15,20,40H,16-19H2,1-3H3,(H,31,32,34) TWYAUJSGFHQKSM-UHFFFAOYSA-N 50615049 CHEMBL5289449 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615049&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171351565 494504797 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528358 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C2CCCC=C2)c3=O)cc1 InChI=1S/C30H36N8O2/c1-30(2,40)25-10-7-11-26(33-25)38-27-24(28(39)37(38)23-8-5-4-6-9-23)20-31-29(34-27)32-21-12-14-22(15-13-21)36-18-16-35(3)17-19-36/h5,7-8,10-15,20,23,40H,4,6,9,16-19H2,1-3H3,(H,31,32,34) JJEGWIJBJXWVDU-UHFFFAOYSA-N 50615050 CHEMBL5274253 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615050&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171355423 494504798 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528359 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n([C@H]2CCCC=C2)c3=O)cc1 InChI=1S/C30H36N8O2/c1-30(2,40)25-10-7-11-26(33-25)38-27-24(28(39)37(38)23-8-5-4-6-9-23)20-31-29(34-27)32-21-12-14-22(15-13-21)36-18-16-35(3)17-19-36/h5,7-8,10-15,20,23,40H,4,6,9,16-19H2,1-3H3,(H,31,32,34)/t23-/m1/s1 JJEGWIJBJXWVDU-HSZRJFAPSA-N 50615036 CHEMBL5269559 Serine/threonine-protein kinase PLK1 Homo sapiens 5830 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615036&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171342284 494504784 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528360 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n([C@@H]2CCCC=C2)c3=O)cc1 InChI=1S/C30H36N8O2/c1-30(2,40)25-10-7-11-26(33-25)38-27-24(28(39)37(38)23-8-5-4-6-9-23)20-31-29(34-27)32-21-12-14-22(15-13-21)36-18-16-35(3)17-19-36/h5,7-8,10-15,20,23,40H,4,6,9,16-19H2,1-3H3,(H,31,32,34)/t23-/m0/s1 JJEGWIJBJXWVDU-QHCPKHFHSA-N 50615051 CHEMBL5285960 Serine/threonine-protein kinase PLK1 Homo sapiens 3432 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615051&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171346171 494504799 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528361 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C2CCC=C2)c3=O)cc1 InChI=1S/C29H34N8O2/c1-29(2,39)24-9-6-10-25(32-24)37-26-23(27(38)36(37)22-7-4-5-8-22)19-30-28(33-26)31-20-11-13-21(14-12-20)35-17-15-34(3)16-18-35/h4,6-7,9-14,19,22,39H,5,8,15-18H2,1-3H3,(H,30,31,33) LZTPSBCGWGMOMP-UHFFFAOYSA-N 50615052 CHEMBL5283530 Serine/threonine-protein kinase PLK1 Homo sapiens 4600 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615052&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171346624 494504800 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528362 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n([C@H]2CCC=C2)c3=O)cc1 InChI=1S/C29H34N8O2/c1-29(2,39)24-9-6-10-25(32-24)37-26-23(27(38)36(37)22-7-4-5-8-22)19-30-28(33-26)31-20-11-13-21(14-12-20)35-17-15-34(3)16-18-35/h4,6-7,9-14,19,22,39H,5,8,15-18H2,1-3H3,(H,30,31,33)/t22-/m1/s1 LZTPSBCGWGMOMP-JOCHJYFZSA-N 50615053 CHEMBL5291191 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171351998 494504801 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528363 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n([C@@H]2CCC=C2)c3=O)cc1 InChI=1S/C29H34N8O2/c1-29(2,39)24-9-6-10-25(32-24)37-26-23(27(38)36(37)22-7-4-5-8-22)19-30-28(33-26)31-20-11-13-21(14-12-20)35-17-15-34(3)16-18-35/h4,6-7,9-14,19,22,39H,5,8,15-18H2,1-3H3,(H,30,31,33)/t22-/m0/s1 LZTPSBCGWGMOMP-QFIPXVFZSA-N 50615054 CHEMBL5289458 Serine/threonine-protein kinase PLK1 Homo sapiens 4200 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615054&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171351569 494504802 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528364 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C2CCCCC2)c3=O)cc1 InChI=1S/C30H38N8O2/c1-30(2,40)25-10-7-11-26(33-25)38-27-24(28(39)37(38)23-8-5-4-6-9-23)20-31-29(34-27)32-21-12-14-22(15-13-21)36-18-16-35(3)17-19-36/h7,10-15,20,23,40H,4-6,8-9,16-19H2,1-3H3,(H,31,32,34) CDPGFMXRUSHTCC-UHFFFAOYSA-N 50615055 CHEMBL5277202 Serine/threonine-protein kinase PLK1 Homo sapiens 9000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615055&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171356880 494504803 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528365 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C2CCCC2)c3=O)cc1 InChI=1S/C29H36N8O2/c1-29(2,39)24-9-6-10-25(32-24)37-26-23(27(38)36(37)22-7-4-5-8-22)19-30-28(33-26)31-20-11-13-21(14-12-20)35-17-15-34(3)16-18-35/h6,9-14,19,22,39H,4-5,7-8,15-18H2,1-3H3,(H,30,31,33) IBFWZLVKHAJJDH-UHFFFAOYSA-N 50615056 CHEMBL5266147 Serine/threonine-protein kinase PLK1 Homo sapiens 1800 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615056&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171350423 494504804 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528366 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC2CCC2)c3=O)cc1 InChI=1S/C29H36N8O2/c1-29(2,39)24-8-5-9-25(32-24)37-26-23(27(38)36(37)19-20-6-4-7-20)18-30-28(33-26)31-21-10-12-22(13-11-21)35-16-14-34(3)15-17-35/h5,8-13,18,20,39H,4,6-7,14-17,19H2,1-3H3,(H,30,31,33) QTVNJKDDNWPPBS-UHFFFAOYSA-N 50615057 CHEMBL5287283 Serine/threonine-protein kinase PLK1 Homo sapiens 1800 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615057&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171346486 494504805 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528367 COCCn1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O InChI=1S/C27H34N8O3/c1-27(2,37)22-6-5-7-23(30-22)35-24-21(25(36)34(35)16-17-38-4)18-28-26(31-24)29-19-8-10-20(11-9-19)33-14-12-32(3)13-15-33/h5-11,18,37H,12-17H2,1-4H3,(H,28,29,31) UOFKPXJMZQVPLP-UHFFFAOYSA-N 50615058 CHEMBL5269419 Serine/threonine-protein kinase PLK1 Homo sapiens 1500 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615058&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171342809 494504806 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528368 CC(C)n1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O InChI=1S/C27H34N8O2/c1-18(2)34-25(36)21-17-28-26(29-19-9-11-20(12-10-19)33-15-13-32(5)14-16-33)31-24(21)35(34)23-8-6-7-22(30-23)27(3,4)37/h6-12,17-18,37H,13-16H2,1-5H3,(H,28,29,31) ISZVUZJIEBIZNI-UHFFFAOYSA-N 50615059 CHEMBL5286445 Serine/threonine-protein kinase PLK1 Homo sapiens 170 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615059&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 24856527 494504807 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528369 CCCn1n(-c2cccc(n2)C(C)(C)O)c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2c1=O InChI=1S/C27H34N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h6-12,18,37H,5,13-17H2,1-4H3,(H,28,29,31) WVTOUIFLKZJSCS-UHFFFAOYSA-N 50615060 CHEMBL5277502 Serine/threonine-protein kinase PLK1 Homo sapiens 480 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615060&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156768392 494504808 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528370 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(C)c3=O)cc1 InChI=1S/C25H30N8O2/c1-25(2,35)20-6-5-7-21(28-20)33-22-19(23(34)31(33)4)16-26-24(29-22)27-17-8-10-18(11-9-17)32-14-12-30(3)13-15-32/h5-11,16,35H,12-15H2,1-4H3,(H,26,27,29) BVVMGUQEMUEAHE-UHFFFAOYSA-N 50615061 CHEMBL5266086 Serine/threonine-protein kinase PLK1 Homo sapiens 250 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615061&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 59556002 494504809 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528371 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n([nH]c3=O)-c2cccc(n2)C(C)(C)O)cc1 InChI=1S/C24H28N8O2/c1-24(2,34)19-5-4-6-20(27-19)32-21-18(22(33)29-32)15-25-23(28-21)26-16-7-9-17(10-8-16)31-13-11-30(3)12-14-31/h4-10,15,34H,11-14H2,1-3H3,(H,29,33)(H,25,26,28) FASYQNVBURRMKN-UHFFFAOYSA-N 50615062 CHEMBL5280012 Serine/threonine-protein kinase PLK1 Homo sapiens 1500 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615062&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 153338806 494504810 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528372 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1 InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31) BKWJAKQVGHWELA-UHFFFAOYSA-N 50240826 AZD-1775::MK-1775::US11124518, Example AZD1775::US11248006, Compound AZD1775::US11479555, Example AZD1775 Serine/threonine-protein kinase PLK1 Homo sapiens 124 ChEMBL 10.7270/Q2Z89HN6 37197456 Guler, S; DiPoto, MC; Crespo, A; Caldwell, R; Doerfel, B; Grossmann, N; Ho, K; Huck, B; Jones, CC; Lan, R; Musil, D; Potnick, J; Schilke, H; Sherer, B; Simon, S; Sirrenberg, C; Zhang, Z; Liu-Bujalski, L Emd Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 8X7 5VDK,5VD0,5V5Y,8BJT 24856436 386401532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528373 CN(C)C1CCN(CC1)c1c(C)cc(Nc2ncc3C(=O)N(C4=NCCN4c3n2)c2c(Cl)cccc2Cl)cc1F InChI=1S/C28H29Cl2FN8O/c1-16-13-17(14-22(31)23(16)37-10-7-18(8-11-37)36(2)3)34-27-33-15-19-25(35-27)38-12-9-32-28(38)39(26(19)40)24-20(29)5-4-6-21(24)30/h4-6,13-15,18H,7-12H2,1-3H3,(H,33,34,35) YFNATPFSAZZDDV-UHFFFAOYSA-N 50615063 CHEMBL5285363 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615063&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 139503271 494504811 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528374 CN1Cc2ccc(Nc3ncc4c(n3)n(C)cc(-c3c(Cl)cccc3Cl)c4=O)cc2C1 InChI=1S/C23H19Cl2N5O/c1-29-10-13-6-7-15(8-14(13)11-29)27-23-26-9-16-21(31)17(12-30(2)22(16)28-23)20-18(24)4-3-5-19(20)25/h3-9,12H,10-11H2,1-2H3,(H,26,27,28) VWMUXXQYMWYAAA-UHFFFAOYSA-N 50615064 CHEMBL5290136 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615064&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 71555644 494504812 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528375 CC1(C)CNCc2cc(Nc3ncc4c(ccn(-c5c(Cl)cccc5Cl)c4=O)n3)ccc12 InChI=1S/C24H21Cl2N5O/c1-24(2)13-27-11-14-10-15(6-7-17(14)24)29-23-28-12-16-20(30-23)8-9-31(22(16)32)21-18(25)4-3-5-19(21)26/h3-10,12,27H,11,13H2,1-2H3,(H,28,29,30) ALMVORCDEJHPLC-UHFFFAOYSA-N 50615065 CHEMBL5280227 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615065&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171356642 494504813 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528376 CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O InChI=1S/C26H26Cl2N6O/c1-3-34-24-17(15-20(25(34)35)23-21(27)5-4-6-22(23)28)16-29-26(31-24)30-18-7-9-19(10-8-18)33-13-11-32(2)12-14-33/h4-10,15-16H,3,11-14H2,1-2H3,(H,29,30,31) CVBFLZPOJZBXKW-UHFFFAOYSA-N 50615066 CHEMBL5266595 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615066&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171350180 494504814 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528377 CN1CCc2ccc(Nc3cc4n(-c5cc(ccn5)C(C)(C)O)n(CC=C)c(=O)c4cn3)cc2C1 InChI=1S/C27H30N6O2/c1-5-11-32-26(34)22-16-29-24(30-21-7-6-18-9-12-31(4)17-19(18)13-21)15-23(22)33(32)25-14-20(8-10-28-25)27(2,3)35/h5-8,10,13-16,35H,1,9,11-12,17H2,2-4H3,(H,29,30) AULWOQPQUKPJMM-UHFFFAOYSA-N 50615067 CHEMBL5275152 Serine/threonine-protein kinase PLK1 Homo sapiens >25000 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615067&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171355833 494504815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528378 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)c2n(C)ccc12 InChI=1S/C30H35N9O2/c1-6-13-38-28(40)21-19-31-29(34-27(21)39(38)25-9-7-8-24(33-25)30(2,3)41)32-22-10-11-23(20-12-14-36(5)26(20)22)37-17-15-35(4)16-18-37/h6-12,14,19,41H,1,13,15-18H2,2-5H3,(H,31,32,34) ITVQDQHPDYLMCH-UHFFFAOYSA-N 50615068 CHEMBL5272327 Serine/threonine-protein kinase PLK1 Homo sapiens 16 ChEMBL 10.7270/Q2Z89HN6 37197456 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615068&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171349098 494504816 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51528379 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 2.5 ChEMBL 10.7270/Q2Z89HN6 37197456 Guler, S; DiPoto, MC; Crespo, A; Caldwell, R; Doerfel, B; Grossmann, N; Ho, K; Huck, B; Jones, CC; Lan, R; Musil, D; Potnick, J; Schilke, H; Sherer, B; Simon, S; Sirrenberg, C; Zhang, Z; Liu-Bujalski, L Emd Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51527949 CS(=O)(=O)N1CCC2(CC1)NC(=O)C(=N2)c1ccc(Br)cc1 InChI=1S/C14H16BrN3O3S/c1-22(20,21)18-8-6-14(7-9-18)16-12(13(19)17-14)10-2-4-11(15)5-3-10/h2-5H,6-9H2,1H3,(H,17,19) PTJHYSBTEDYVLZ-UHFFFAOYSA-N 50614762 CHEMBL5285754 Serine/threonine-protein kinase PLK1 Homo sapiens 20400 ChEMBL 10.7270/Q25143JF 37094724 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50614762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50614762&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 53029828 494504510 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51525342 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26+,28-/m1/s1 SXNJFOWDRLKDSF-FULLSBAXSA-N 50613682 CHEMBL5276995 Serine/threonine-protein kinase PLK1 Homo sapiens 0.870000 ChEMBL 10.7270/Q2GX4GVS 27559828 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50613682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50613682&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 10461508 494503430 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51529609 CCn1c(=O)\c(=C\Nc2cccc(CCN3CCCC3)c2)s\c1=C(/C#N)C(=O)NC(F)(F)F InChI=1S/C22H24F3N5O2S/c1-2-30-20(32)18(33-21(30)17(13-26)19(31)28-22(23,24)25)14-27-16-7-5-6-15(12-16)8-11-29-9-3-4-10-29/h5-7,12,14,27H,2-4,8-11H2,1H3,(H,28,31)/b18-14-,21-17+ JINUYEMGHKIEKW-ADDAYVOGSA-N 50615459 CHEMBL5281562 Serine/threonine-protein kinase PLK1 Homo sapiens 19 ChEMBL 10.7270/Q2HX1HX8 28987611 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615459&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171354975 494505207 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352085 CCOP(=O)(CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O)OCC InChI=1S/C15H18FN4O4PS/c1-3-23-25(22,24-4-2)8-7-19-13(21)11-9-10(16)5-6-12(11)20-14(19)17-18-15(20)26/h5-6,9H,3-4,7-8H2,1-2H3,(H,18,26) MBBHMDUYGKSPSI-UHFFFAOYSA-N 50548899 CHEMBL4752841::US20230365568, Compound 78 Serine/threonine-protein kinase PLK1 Homo sapiens 13890 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548899&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652487 461679239 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352086 Fc1ccc2c(c1)c(=O)n(CC1CC1)c1n[nH]c(=S)n21 InChI=1S/C13H11FN4OS/c14-8-3-4-10-9(5-8)11(19)17(6-7-1-2-7)12-15-16-13(20)18(10)12/h3-5,7H,1-2,6H2,(H,16,20) JSRQZDANZDRJOA-UHFFFAOYSA-N 50548834 CHEMBL4786053::US20230365568, Compound 79 Serine/threonine-protein kinase PLK1 Homo sapiens 770 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548834&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667407 461679174 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352087 C[C@H]1C[C@@H]1n1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548900 CHEMBL4750016::US20230365568, Compound 80 Serine/threonine-protein kinase PLK1 Homo sapiens 1190 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548900&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162651097 461679240 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352088 Fc1ccc2c(c1)c(=O)n(CCc1ccccc1Cl)c1n[nH]c(=S)n21 InChI=1S/C17H12ClFN4OS/c18-13-4-2-1-3-10(13)7-8-22-15(24)12-9-11(19)5-6-14(12)23-16(22)20-21-17(23)25/h1-6,9H,7-8H2,(H,21,25) BCWCCLYQOIMHQZ-UHFFFAOYSA-N 50548901 CHEMBL4760146::US20230365568, Compound 81 Serine/threonine-protein kinase PLK1 Homo sapiens 14370 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548901&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162658417 461679241 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352089 Fc1ccc2c(c1)c(=O)n(CCc1ccc(Cl)cc1)c1n[nH]c(=S)n21 InChI=1S/C17H12ClFN4OS/c18-11-3-1-10(2-4-11)7-8-22-15(24)13-9-12(19)5-6-14(13)23-16(22)20-21-17(23)25/h1-6,9H,7-8H2,(H,21,25) OIEUULLHZMEIQJ-UHFFFAOYSA-N 50548902 CHEMBL4748084::US20230365568, Compound 82 Serine/threonine-protein kinase PLK1 Homo sapiens 5710 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548902&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650058 461679242 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352090 Fc1ccc2c(c1)c(=O)n(CCc1ccccn1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-10-4-5-13-12(9-10)14(23)21(15-19-20-16(24)22(13)15)8-6-11-3-1-2-7-18-11/h1-5,7,9H,6,8H2,(H,20,24) DKCRYDVGUXVEGT-UHFFFAOYSA-N 50548903 CHEMBL4755098::US20230365568, Compound 83 Serine/threonine-protein kinase PLK1 Homo sapiens 870 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548903&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654749 461679243 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352091 Fc1ccc2c(c1)c(=O)n(CCc1cccnc1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-11-3-4-13-12(8-11)14(23)21(15-19-20-16(24)22(13)15)7-5-10-2-1-6-18-9-10/h1-4,6,8-9H,5,7H2,(H,20,24) WKMISPZKBDDFFG-UHFFFAOYSA-N 50548904 CHEMBL4789412::US20230365568, Compound 84 Serine/threonine-protein kinase PLK1 Homo sapiens 1070 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548904&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668665 461679244 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352092 Fc1ccc2c(c1)c(=O)n(CCc1ccncc1)c1n[nH]c(=S)n21 InChI=1S/C16H12FN5OS/c17-11-1-2-13-12(9-11)14(23)21(15-19-20-16(24)22(13)15)8-5-10-3-6-18-7-4-10/h1-4,6-7,9H,5,8H2,(H,20,24) ZMGSXMDCXVONSV-UHFFFAOYSA-N 50548905 CHEMBL4755584::US20230365568, Compound 85 Serine/threonine-protein kinase PLK1 Homo sapiens 890 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548905&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656087 461679245 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352093 CC(C)(C)OC(=O)N1CC(CCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)C1 InChI=1S/C19H22FN5O3S/c1-19(2,3)28-18(27)23-9-11(10-23)6-7-24-15(26)13-8-12(20)4-5-14(13)25-16(24)21-22-17(25)29/h4-5,8,11H,6-7,9-10H2,1-3H3,(H,22,29) YQPWEPIHGPBEJY-UHFFFAOYSA-N 50548906 CHEMBL4756117::US20230365568, Compound 86 Serine/threonine-protein kinase PLK1 Homo sapiens 5670 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548906&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656006 461679246 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352094 CN1CCCC1CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548907 CHEMBL4745295::US20230365568, Compound 87 Serine/threonine-protein kinase PLK1 Homo sapiens 5670 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548907&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162647550 461679247 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352095 Fc1ccc2c(c1)c(=O)n(CCN1CCCCC1)c1n[nH]c(=S)n21 InChI=1S/C16H18FN5OS/c17-11-4-5-13-12(10-11)14(23)21(15-18-19-16(24)22(13)15)9-8-20-6-2-1-3-7-20/h4-5,10H,1-3,6-9H2,(H,19,24) YXGKVGCKFWARNG-UHFFFAOYSA-N 50548908 CHEMBL4762683::US20230365568, Compound 88 Serine/threonine-protein kinase PLK1 Homo sapiens 1510 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548908&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659781 461679248 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352096 Fc1ccc2c(c1)c(=O)n(CCN1CCC(F)(F)CC1)c1n[nH]c(=S)n21 InChI=1S/C16H16F3N5OS/c17-10-1-2-12-11(9-10)13(25)23(14-20-21-15(26)24(12)14)8-7-22-5-3-16(18,19)4-6-22/h1-2,9H,3-8H2,(H,21,26) DSAGYMBRXXAGLY-UHFFFAOYSA-N 50548909 CHEMBL4758964::US20230365568, Compound 89 Serine/threonine-protein kinase PLK1 Homo sapiens 1370 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548909&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657667 461679249 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352097 Fc1ccc2c(c1)c(=O)n(CCN1CCOCC1)c1n[nH]c(=S)n21 InChI=1S/C15H16FN5O2S/c16-10-1-2-12-11(9-10)13(22)20(14-17-18-15(24)21(12)14)4-3-19-5-7-23-8-6-19/h1-2,9H,3-8H2,(H,18,24) IAGFGMNTHAVBKQ-UHFFFAOYSA-N 50548910 CHEMBL4776438::US20230365568, Compound 90 Serine/threonine-protein kinase PLK1 Homo sapiens 1630 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548910&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162642990 461679250 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352098 CN1CCN(CCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)CC1 InChI=1S/C16H19FN6OS/c1-20-4-6-21(7-5-20)8-9-22-14(24)12-10-11(17)2-3-13(12)23-15(22)18-19-16(23)25/h2-3,10H,4-9H2,1H3,(H,19,25) LVSISVIBJUEAPP-UHFFFAOYSA-N 50548911 CHEMBL4753166::US20230365568, Compound 91 Serine/threonine-protein kinase PLK1 Homo sapiens 6720 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548911&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162653654 461679251 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352099 CC(C)(C)OC(=O)N1CCN(CCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)CC1 InChI=1S/C20H25FN6O3S/c1-20(2,3)30-19(29)25-9-6-24(7-10-25)8-11-26-16(28)14-12-13(21)4-5-15(14)27-17(26)22-23-18(27)31/h4-5,12H,6-11H2,1-3H3,(H,23,31) BPUVBJZPYYTFDJ-UHFFFAOYSA-N 50548912 CHEMBL4756791::US20230365568, Compound 92 Serine/threonine-protein kinase PLK1 Homo sapiens 1840 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548912&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655841 461679252 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352100 Fc1ccc2c(c1)c(=O)n(CCC1CCC(F)(F)CC1)c1n[nH]c(=S)n21 InChI=1S/C17H17F3N4OS/c18-11-1-2-13-12(9-11)14(25)23(15-21-22-16(26)24(13)15)8-5-10-3-6-17(19,20)7-4-10/h1-2,9-10H,3-8H2,(H,22,26) SMSXXOCVHDEVRC-UHFFFAOYSA-N 50548913 CHEMBL4791849::US20230365568, Compound 93 Serine/threonine-protein kinase PLK1 Homo sapiens 2830 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548913&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162671203 461679253 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352101 NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C23H33FN6O6S/c24-17-2-3-19-18(16-17)21(32)29(22-27-28-23(37)30(19)22)7-1-6-26-20(31)4-8-33-10-12-35-14-15-36-13-11-34-9-5-25/h2-3,16H,1,4-15,25H2,(H,26,31)(H,28,37) HTUISLORSNIXSN-UHFFFAOYSA-N 50548914 CHEMBL4784833::US20230365568, Compound 94 Serine/threonine-protein kinase PLK1 Homo sapiens 5360 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548914&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162666368 461679254 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352102 CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C28H41FN6O8S/c1-28(2,3)43-27(38)31-9-12-40-14-16-42-18-17-41-15-13-39-11-7-23(36)30-8-4-10-34-24(37)21-19-20(29)5-6-22(21)35-25(34)32-33-26(35)44/h5-6,19H,4,7-18H2,1-3H3,(H,30,36)(H,31,38)(H,33,44) BRFGJROSYKQLMG-UHFFFAOYSA-N 50548915 CHEMBL4778069::US20230365568, Compound 95 Serine/threonine-protein kinase PLK1 Homo sapiens 3220 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548915&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644471 461679255 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352103 N[C@@H](CCC(O)=O)C(=O)NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548916 CHEMBL4780772::US20230365568, Compound 96 Serine/threonine-protein kinase PLK1 Homo sapiens 13130 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548916&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662450 461679256 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352104 CC(C)(C)OC(=O)CC[C@H](N)C(=O)NCCOCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548917 CHEMBL4762021::US20230365568, Compound 97 Serine/threonine-protein kinase PLK1 Homo sapiens 9400 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548917&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659553 461679257 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352105 NCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C21H29FN6O5S/c22-15-2-3-17-16(14-15)19(30)27(20-25-26-21(34)28(17)20)7-1-6-24-18(29)4-8-31-10-12-33-13-11-32-9-5-23/h2-3,14H,1,4-13,23H2,(H,24,29)(H,26,34) OAUOUODYDIVWSJ-UHFFFAOYSA-N 50548918 CHEMBL4761447::US20230365568, Compound 98 Serine/threonine-protein kinase PLK1 Homo sapiens 5020 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548918&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162660095 461679258 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352106 CC(C)(C)OC(=O)NCCOCCOCCOCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C26H37FN6O7S/c1-26(2,3)40-25(36)29-9-12-38-14-16-39-15-13-37-11-7-21(34)28-8-4-10-32-22(35)19-17-18(27)5-6-20(19)33-23(32)30-31-24(33)41/h5-6,17H,4,7-16H2,1-3H3,(H,28,34)(H,29,36)(H,31,41) PJJZFIBVFHIINE-UHFFFAOYSA-N 50548919 CHEMBL4798911::US20230365568, Compound 99 Serine/threonine-protein kinase PLK1 Homo sapiens 2880 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675900 461679259 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352107 NCCCCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C18H23FN6O2S/c19-12-6-7-14-13(11-12)16(27)24(17-22-23-18(28)25(14)17)10-4-9-21-15(26)5-2-1-3-8-20/h6-7,11H,1-5,8-10,20H2,(H,21,26)(H,23,28) NPRUYNMTXRGZCY-UHFFFAOYSA-N 50548920 CHEMBL4787926::US20230365568, Compound 100 Serine/threonine-protein kinase PLK1 Homo sapiens 3040 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548920&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669090 461679260 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352108 CC(C)(C)OC(=O)NCCCCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C23H31FN6O4S/c1-23(2,3)34-22(33)26-11-6-4-5-8-18(31)25-12-7-13-29-19(32)16-14-15(24)9-10-17(16)30-20(29)27-28-21(30)35/h9-10,14H,4-8,11-13H2,1-3H3,(H,25,31)(H,26,33)(H,28,35) UXODQXNDFBWBFG-UHFFFAOYSA-N 50548921 CHEMBL4759486::US20230365568, Compound 101 Serine/threonine-protein kinase PLK1 Homo sapiens 3230 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548921&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657883 461679261 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352109 CC(C)(C)OC(=O)CC[C@@H](NC(=O)OC(C)(C)C)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548922 CHEMBL4749397::US20230365568, Compound 102 Serine/threonine-protein kinase PLK1 Homo sapiens 8190 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548922&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162651408 461679262 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352110 CC(C)(C)OC(=O)CC[C@H](NC(=O)OC(C)(C)C)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548923 CHEMBL4742063::US20230365568, Compound 103 Serine/threonine-protein kinase PLK1 Homo sapiens 3310 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548923&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646701 461679263 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352111 CC(C)(C)OC(=O)CC[C@H](N)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548924 CHEMBL4794603::US20230365568, Compound 104 Serine/threonine-protein kinase PLK1 Homo sapiens 2330 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548924&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674321 461679264 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352112 N[C@@H](CCC(O)=O)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548925 CHEMBL4776697::US20230365568, Compound 105 Serine/threonine-protein kinase PLK1 Homo sapiens 12650 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548925&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643153 461679265 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352113 OC(=O)CCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C16H16FN5O4S/c17-9-2-3-11-10(8-9)14(26)21(15-19-20-16(27)22(11)15)7-1-6-18-12(23)4-5-13(24)25/h2-3,8H,1,4-7H2,(H,18,23)(H,20,27)(H,24,25) BLXWQQCERCCKQU-UHFFFAOYSA-N 50548926 CHEMBL4764548::US20230365568, Compound 106 Serine/threonine-protein kinase PLK1 Homo sapiens 5050 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548926&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662199 461679266 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352114 NS(=O)(=O)CCCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C16H19FN6O4S2/c17-10-4-5-12-11(9-10)14(25)22(15-20-21-16(28)23(12)15)7-2-6-19-13(24)3-1-8-29(18,26)27/h4-5,9H,1-3,6-8H2,(H,19,24)(H,21,28)(H2,18,26,27) PWGLZWTVFBLIDR-UHFFFAOYSA-N 50548927 CHEMBL4777570::US20230365568, Compound 107 Serine/threonine-protein kinase PLK1 Homo sapiens 2180 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548927&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644402 461679267 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352115 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCCC1)c1n[nH]c(=S)n21 InChI=1S/C18H20FN5O2S/c19-12-6-7-14-13(10-12)16(26)23(17-21-22-18(27)24(14)17)9-3-8-20-15(25)11-4-1-2-5-11/h6-7,10-11H,1-5,8-9H2,(H,20,25)(H,22,27) OKQDPRMSQDTVMY-UHFFFAOYSA-N 50548928 CHEMBL4795697::US20230365568, Compound 108 Serine/threonine-protein kinase PLK1 Homo sapiens 1470 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548928&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162673236 461679268 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352116 CC(C)(C)[C@H]1CC[C@@H](CC1)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548929 CHEMBL4754725::US20230365568, Compound 109 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548929&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654546 461679269 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352117 CC(C)(C)OC(=O)NC1CCC(CC1)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C24H31FN6O4S/c1-24(2,3)35-23(34)27-16-8-5-14(6-9-16)19(32)26-11-4-12-30-20(33)17-13-15(25)7-10-18(17)31-21(30)28-29-22(31)36/h7,10,13-14,16H,4-6,8-9,11-12H2,1-3H3,(H,26,32)(H,27,34)(H,29,36) HSQIWIFWKHJOJB-UHFFFAOYSA-N 50548930 CHEMBL4762825::US20230365568, Compound 110 Serine/threonine-protein kinase PLK1 Homo sapiens 2380 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659361 461679270 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352118 NC1CCC(CC1)C(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C19H23FN6O2S/c20-12-4-7-15-14(10-12)17(28)25(18-23-24-19(29)26(15)18)9-1-8-22-16(27)11-2-5-13(21)6-3-11/h4,7,10-11,13H,1-3,5-6,8-9,21H2,(H,22,27)(H,24,29) XBMOWNBEYVKSPR-UHFFFAOYSA-N 50548931 CHEMBL4777157::US20230365568, Compound 111 Serine/threonine-protein kinase PLK1 Homo sapiens 3970 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643787 461679271 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352119 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCCCN1)c1n[nH]c(=S)n21 50548932 CHEMBL4786323::US20230365568, Compound 112 Serine/threonine-protein kinase PLK1 Homo sapiens 27660 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667029 461679272 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352120 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCCNC1)c1n[nH]c(=S)n21 50548933 CHEMBL4754165::US20230365568, Compound 113 Serine/threonine-protein kinase PLK1 Homo sapiens 30200 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548933&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654172 461679273 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352121 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCNCC1)c1n[nH]c(=S)n21 InChI=1S/C18H21FN6O2S/c19-12-2-3-14-13(10-12)16(27)24(17-22-23-18(28)25(14)17)9-1-6-21-15(26)11-4-7-20-8-5-11/h2-3,10-11,20H,1,4-9H2,(H,21,26)(H,23,28) QYWNDJFLOZNZMQ-UHFFFAOYSA-N 50548934 CHEMBL4797067::US20230365568, Compound 114 Serine/threonine-protein kinase PLK1 Homo sapiens 44010 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548934&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162676341 461679274 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352122 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)C1CCOCC1)c1n[nH]c(=S)n21 InChI=1S/C18H20FN5O3S/c19-12-2-3-14-13(10-12)16(26)23(17-21-22-18(28)24(14)17)7-1-6-20-15(25)11-4-8-27-9-5-11/h2-3,10-11H,1,4-9H2,(H,20,25)(H,22,28) YIUUGCPBTCTHAZ-UHFFFAOYSA-N 50548935 CHEMBL4785254::US20230365568, Compound 115 Serine/threonine-protein kinase PLK1 Homo sapiens 1790 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548935&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665418 461679275 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352123 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)CC1CCNCC1)c1n[nH]c(=S)n21 InChI=1S/C19H23FN6O2S/c20-13-2-3-15-14(11-13)17(28)25(18-23-24-19(29)26(15)18)9-1-6-22-16(27)10-12-4-7-21-8-5-12/h2-3,11-12,21H,1,4-10H2,(H,22,27)(H,24,29) QODICCGCPVNPQA-UHFFFAOYSA-N 50548936 CHEMBL4762260::US20230365568, Compound 116 Serine/threonine-protein kinase PLK1 Homo sapiens 3960 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548936&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659561 461679276 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352124 CN1CCN(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)CC1 InChI=1S/C19H24FN7O2S/c1-24-7-9-25(10-8-24)12-16(28)21-5-2-6-26-17(29)14-11-13(20)3-4-15(14)27-18(26)22-23-19(27)30/h3-4,11H,2,5-10,12H2,1H3,(H,21,28)(H,23,30) CLIKJUGKPVXNGK-UHFFFAOYSA-N 50548937 CHEMBL4756781::US20230365568, Compound 117 Serine/threonine-protein kinase PLK1 Homo sapiens 4660 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548937&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655709 461679277 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352125 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)CN1CCOCC1)c1n[nH]c(=S)n21 InChI=1S/C18H21FN6O3S/c19-12-2-3-14-13(10-12)16(27)24(17-21-22-18(29)25(14)17)5-1-4-20-15(26)11-23-6-8-28-9-7-23/h2-3,10H,1,4-9,11H2,(H,20,26)(H,22,29) KOMUBOJHKISIJW-UHFFFAOYSA-N 50548938 CHEMBL4796001::US20230365568, Compound 118 Serine/threonine-protein kinase PLK1 Homo sapiens 3770 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548938&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674133 461679278 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352126 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)c1ccc(Cn3ccnc3)cc1)c1n[nH]c(=S)n21 InChI=1S/C23H20FN7O2S/c24-17-6-7-19-18(12-17)21(33)30(22-27-28-23(34)31(19)22)10-1-8-26-20(32)16-4-2-15(3-5-16)13-29-11-9-25-14-29/h2-7,9,11-12,14H,1,8,10,13H2,(H,26,32)(H,28,34) DIJLNXGHNDEKNB-UHFFFAOYSA-N 50548939 CHEMBL4789824::US20230365568, Compound 119 Serine/threonine-protein kinase PLK1 Homo sapiens 1480 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548939&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669731 461679279 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352127 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C20H18FN5O2S/c21-14-7-8-16-15(12-14)18(28)25(19-23-24-20(29)26(16)19)10-4-9-22-17(27)11-13-5-2-1-3-6-13/h1-3,5-8,12H,4,9-11H2,(H,22,27)(H,24,29) ZJAJTDFDSZMRDT-UHFFFAOYSA-N 50548940 CHEMBL4791970::US20230365568, Compound 120 Serine/threonine-protein kinase PLK1 Homo sapiens 1230 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548940&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162670458 461679280 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352128 Cc1noc(C)c1CCC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C20H21FN6O3S/c1-11-14(12(2)30-25-11)5-7-17(28)22-8-3-9-26-18(29)15-10-13(21)4-6-16(15)27-19(26)23-24-20(27)31/h4,6,10H,3,5,7-9H2,1-2H3,(H,22,28)(H,24,31) KSKPPJNANLJXSI-UHFFFAOYSA-N 50548941 CHEMBL4741217::US20230365568, Compound 121 Serine/threonine-protein kinase PLK1 Homo sapiens 1780 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548941&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162645925 461679281 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352129 Fc1cccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)c1 InChI=1S/C20H17F2N5O2S/c21-13-4-1-3-12(9-13)10-17(28)23-7-2-8-26-18(29)15-11-14(22)5-6-16(15)27-19(26)24-25-20(27)30/h1,3-6,9,11H,2,7-8,10H2,(H,23,28)(H,25,30) MFZIKBQATZKNJE-UHFFFAOYSA-N 50548942 CHEMBL4757497::US20230365568, Compound 122 Serine/threonine-protein kinase PLK1 Homo sapiens 1420 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548942&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656981 461679282 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352130 Fc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C20H17F2N5O2S/c21-13-4-2-12(3-5-13)10-17(28)23-8-1-9-26-18(29)15-11-14(22)6-7-16(15)27-19(26)24-25-20(27)30/h2-7,11H,1,8-10H2,(H,23,28)(H,25,30) WAZDLRSDVCWIQX-UHFFFAOYSA-N 50548943 CHEMBL4785186::US20230365568, Compound 123 Serine/threonine-protein kinase PLK1 Homo sapiens 1350 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548943&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162666393 461679283 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352131 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1cccc(Cl)c1)c1n[nH]c(=S)n21 InChI=1S/C20H17ClFN5O2S/c21-13-4-1-3-12(9-13)10-17(28)23-7-2-8-26-18(29)15-11-14(22)5-6-16(15)27-19(26)24-25-20(27)30/h1,3-6,9,11H,2,7-8,10H2,(H,23,28)(H,25,30) DUTLBYFPUBZPJS-UHFFFAOYSA-N 50548944 CHEMBL4754571::US20230365568, Compound 124 Serine/threonine-protein kinase PLK1 Homo sapiens 1150 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548944&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654702 461679284 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352132 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccc(Br)cc1)c1n[nH]c(=S)n21 InChI=1S/C20H17BrFN5O2S/c21-13-4-2-12(3-5-13)10-17(28)23-8-1-9-26-18(29)15-11-14(22)6-7-16(15)27-19(26)24-25-20(27)30/h2-7,11H,1,8-10H2,(H,23,28)(H,25,30) CWGRKPQEWRYLLL-UHFFFAOYSA-N 50548945 CHEMBL4741770::US20230365568, Compound 125 Serine/threonine-protein kinase PLK1 Homo sapiens 1590 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548945&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162647140 461679285 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352133 Cc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C21H20FN5O2S/c1-13-3-5-14(6-4-13)11-18(28)23-9-2-10-26-19(29)16-12-15(22)7-8-17(16)27-20(26)24-25-21(27)30/h3-8,12H,2,9-11H2,1H3,(H,23,28)(H,25,30) ZMBLMPPSRRFODO-UHFFFAOYSA-N 50548946 CHEMBL4762177::US20230365568, Compound 126 Serine/threonine-protein kinase PLK1 Homo sapiens 1180 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548946&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162660794 461679286 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352134 Oc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C20H18FN5O3S/c21-13-4-7-16-15(11-13)18(29)25(19-23-24-20(30)26(16)19)9-1-8-22-17(28)10-12-2-5-14(27)6-3-12/h2-7,11,27H,1,8-10H2,(H,22,28)(H,24,30) RAJFIPOIYIBRSD-UHFFFAOYSA-N 50548947 CHEMBL4742821::US20230365568, Compound 127 Serine/threonine-protein kinase PLK1 Homo sapiens 1160 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548947&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646556 461679287 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352135 COc1ccccc1CC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C21H20FN5O3S/c1-30-17-6-3-2-5-13(17)11-18(28)23-9-4-10-26-19(29)15-12-14(22)7-8-16(15)27-20(26)24-25-21(27)31/h2-3,5-8,12H,4,9-11H2,1H3,(H,23,28)(H,25,31) WWLSVTKNNQDUMY-UHFFFAOYSA-N 50548948 CHEMBL4781698::US20230365568, Compound 128 Serine/threonine-protein kinase PLK1 Homo sapiens 1150 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548948&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664244 461679288 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352136 COc1cccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)c1 InChI=1S/C21H20FN5O3S/c1-30-15-5-2-4-13(10-15)11-18(28)23-8-3-9-26-19(29)16-12-14(22)6-7-17(16)27-20(26)24-25-21(27)31/h2,4-7,10,12H,3,8-9,11H2,1H3,(H,23,28)(H,25,31) ARRRHZTVWRSLIH-UHFFFAOYSA-N 50548949 CHEMBL4782750::US20230365568, Compound 129 Serine/threonine-protein kinase PLK1 Homo sapiens 960 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548949&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664368 461679289 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352137 COc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C21H20FN5O3S/c1-30-15-6-3-13(4-7-15)11-18(28)23-9-2-10-26-19(29)16-12-14(22)5-8-17(16)27-20(26)24-25-21(27)31/h3-8,12H,2,9-11H2,1H3,(H,23,28)(H,25,31) LOVNVBBMCJEQCJ-UHFFFAOYSA-N 50548950 CHEMBL4745902::US20230365568, Compound 130 Serine/threonine-protein kinase PLK1 Homo sapiens 1060 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548950&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162648892 461679290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352138 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccc1C(F)(F)F)c1n[nH]c(=S)n21 InChI=1S/C21H17F4N5O2S/c22-13-6-7-16-14(11-13)18(32)29(19-27-28-20(33)30(16)19)9-3-8-26-17(31)10-12-4-1-2-5-15(12)21(23,24)25/h1-2,4-7,11H,3,8-10H2,(H,26,31)(H,28,33) CCASXWFAFBFAEM-UHFFFAOYSA-N 50548951 CHEMBL4753107::US20230365568, Compound 131 Serine/threonine-protein kinase PLK1 Homo sapiens 1400 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548951&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654023 461679291 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352139 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1cccc(c1)C(F)(F)F)c1n[nH]c(=S)n21 InChI=1S/C21H17F4N5O2S/c22-14-5-6-16-15(11-14)18(32)29(19-27-28-20(33)30(16)19)8-2-7-26-17(31)10-12-3-1-4-13(9-12)21(23,24)25/h1,3-6,9,11H,2,7-8,10H2,(H,26,31)(H,28,33) JTGQNDUYFYKNEC-UHFFFAOYSA-N 50548952 CHEMBL4795057::US20230365568, Compound 132 Serine/threonine-protein kinase PLK1 Homo sapiens 2230 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548952&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675491 461679292 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352140 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccc1C#N)c1n[nH]c(=S)n21 InChI=1S/C21H17FN6O2S/c22-15-6-7-17-16(11-15)19(30)27(20-25-26-21(31)28(17)20)9-3-8-24-18(29)10-13-4-1-2-5-14(13)12-23/h1-2,4-7,11H,3,8-10H2,(H,24,29)(H,26,31) WVGGYGFBIMIPTH-UHFFFAOYSA-N 50548953 CHEMBL4786880::US20230365568, Compound 133 Serine/threonine-protein kinase PLK1 Homo sapiens 1240 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548953&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162667136 461679293 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352141 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccc(cc1)C#N)c1n[nH]c(=S)n21 InChI=1S/C21H17FN6O2S/c22-15-6-7-17-16(11-15)19(30)27(20-25-26-21(31)28(17)20)9-1-8-24-18(29)10-13-2-4-14(12-23)5-3-13/h2-7,11H,1,8-10H2,(H,24,29)(H,26,31) OCVKYBDQGXTDAN-UHFFFAOYSA-N 50548954 CHEMBL4779347::US20230365568, Compound 134 Serine/threonine-protein kinase PLK1 Homo sapiens 990 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548954&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663133 461679294 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352142 CC(C)(C)OC(=O)Nc1ccc(CC(=O)NCCCn2c3n[nH]c(=S)n3c3ccc(F)cc3c2=O)cc1 InChI=1S/C25H27FN6O4S/c1-25(2,3)36-24(35)28-17-8-5-15(6-9-17)13-20(33)27-11-4-12-31-21(34)18-14-16(26)7-10-19(18)32-22(31)29-30-23(32)37/h5-10,14H,4,11-13H2,1-3H3,(H,27,33)(H,28,35)(H,30,37) AKGYWCZMZBGMDX-UHFFFAOYSA-N 50548955 CHEMBL4782976::US20230365568, Compound 135 Serine/threonine-protein kinase PLK1 Homo sapiens 2720 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548955&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162665164 461679295 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352143 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccccn1)c1n[nH]c(=S)n21 InChI=1S/C19H17FN6O2S/c20-12-5-6-15-14(10-12)17(28)25(18-23-24-19(29)26(15)18)9-3-8-22-16(27)11-13-4-1-2-7-21-13/h1-2,4-7,10H,3,8-9,11H2,(H,22,27)(H,24,29) OFSLVXWAMBVHNF-UHFFFAOYSA-N 50548956 CHEMBL4799166::US20230365568, Compound 136 Serine/threonine-protein kinase PLK1 Homo sapiens 5340 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548956&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674799 461679296 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352144 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1cccnc1)c1n[nH]c(=S)n21 InChI=1S/C19H17FN6O2S/c20-13-4-5-15-14(10-13)17(28)25(18-23-24-19(29)26(15)18)8-2-7-22-16(27)9-12-3-1-6-21-11-12/h1,3-6,10-11H,2,7-9H2,(H,22,27)(H,24,29) DOQXTXOFMUXBQO-UHFFFAOYSA-N 50548957 CHEMBL4747182::US20230365568, Compound 137 Serine/threonine-protein kinase PLK1 Homo sapiens 2500 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548957&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649947 461679297 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352145 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)Cc1ccncc1)c1n[nH]c(=S)n21 InChI=1S/C19H17FN6O2S/c20-13-2-3-15-14(11-13)17(28)25(18-23-24-19(29)26(15)18)9-1-6-22-16(27)10-12-4-7-21-8-5-12/h2-5,7-8,11H,1,6,9-10H2,(H,22,27)(H,24,29) OCNYRTDIUVCJLS-UHFFFAOYSA-N 50548958 CHEMBL4761120::US20230365568, Compound 138 Serine/threonine-protein kinase PLK1 Homo sapiens 3010 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548958&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659684 461679298 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352146 CCCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H12N4OS/c1-2-7-15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h3-6H,2,7H2,1H3,(H,14,18) VTEKNXCWZXDPEY-UHFFFAOYSA-N 60899 4-propyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-propyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001170914::SMR000588314::US20230365568, Compound 21::cid_2423905 Serine/threonine-protein kinase PLK1 Homo sapiens 1030 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60899&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2423905 252640127 ZINC06472729 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352147 CCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H11FN4OS/c1-2-5-16-10(18)8-6-7(13)3-4-9(8)17-11(16)14-15-12(17)19/h3-4,6H,2,5H2,1H3,(H,15,19) ICNXHKBTCLSKNU-UHFFFAOYSA-N 50548885 CHEMBL4793697::US20230365568, Compound 64 Serine/threonine-protein kinase PLK1 Homo sapiens 1160 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548885&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743203 461679225 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352148 CCCn1c2n[nH]c(=S)n2c2c(F)cccc2c1=O InChI=1S/C12H11FN4OS/c1-2-6-16-10(18)7-4-3-5-8(13)9(7)17-11(16)14-15-12(17)19/h3-5H,2,6H2,1H3,(H,15,19) XBKUXOLIYAXVGG-UHFFFAOYSA-N 50548959 CHEMBL4758334::US20230365568, Compound 139 Serine/threonine-protein kinase PLK1 Homo sapiens 2060 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548959&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162656377 461679299 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352149 CCCn1c2n[nH]c(=S)n2c2c(Cl)cccc2c1=O InChI=1S/C12H11ClN4OS/c1-2-6-16-10(18)7-4-3-5-8(13)9(7)17-11(16)14-15-12(17)19/h3-5H,2,6H2,1H3,(H,15,19) PTFZQKOKWSGNMN-UHFFFAOYSA-N 50548960 CHEMBL4797725::US20230365568, Compound 140 Serine/threonine-protein kinase PLK1 Homo sapiens 2490 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548960&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162675963 461679300 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352150 CCCn1c2n[nH]c(=S)n2c2c(OC)cccc2c1=O InChI=1S/C13H14N4O2S/c1-3-7-16-11(18)8-5-4-6-9(19-2)10(8)17-12(16)14-15-13(17)20/h4-6H,3,7H2,1-2H3,(H,15,20) KBSVZLHQKCTESW-UHFFFAOYSA-N 50548961 CHEMBL4747386::US20230365568, Compound 141 Serine/threonine-protein kinase PLK1 Homo sapiens 2430 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548961&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650368 461679301 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352151 CCCn1c2nnc(SC(C)=O)n2c2ccccc2c1=O InChI=1S/C14H14N4O2S/c1-3-8-17-12(20)10-6-4-5-7-11(10)18-13(17)15-16-14(18)21-9(2)19/h4-7H,3,8H2,1-2H3 BNYKCYPINRXOND-UHFFFAOYSA-N 50548962 CHEMBL4748570::US20230365568, Compound 142 Serine/threonine-protein kinase PLK1 Homo sapiens 1330 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548962&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650532 461679302 C04334 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352152 CCCn1c2nnc(SC)n2c2ccccc2c1=O InChI=1S/C13H14N4OS/c1-3-8-16-11(18)9-6-4-5-7-10(9)17-12(16)14-15-13(17)19-2/h4-7H,3,8H2,1-2H3 QCMQLIPWNDLWDB-UHFFFAOYSA-N 91532 1-(methylthio)-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one::1-methylsulfanyl-4-propyl-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS-0471508.0001::US20230365568, Compound 143::cid_16370143 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=91532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=91532&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 16370143 252663057 ZINC09882276 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352153 CCCn1c2nnc(SC)n2c2ccc(F)cc2c1=O InChI=1S/C13H13FN4OS/c1-3-6-17-11(19)9-7-8(14)4-5-10(9)18-12(17)15-16-13(18)20-2/h4-5,7H,3,6H2,1-2H3 WDDVKESXYYVHRR-UHFFFAOYSA-N 50548963 CHEMBL4753937::US20230365568, Compound 144 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548963&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654583 461679303 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352154 CCCn1c2nnc(SC)n2c2c(F)cccc2c1=O InChI=1S/C13H13FN4OS/c1-3-7-17-11(19)8-5-4-6-9(14)10(8)18-12(17)15-16-13(18)20-2/h4-6H,3,7H2,1-2H3 NYTBRBJXPKJNBN-UHFFFAOYSA-N 50548964 CHEMBL4741356::US20230365568, Compound 145 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548964&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162645453 461679304 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352155 CCCn1c2nnc(SC)n2c2c(Cl)cccc2c1=O InChI=1S/C13H13ClN4OS/c1-3-7-17-11(19)8-5-4-6-9(14)10(8)18-12(17)15-16-13(18)20-2/h4-6H,3,7H2,1-2H3 VQEXWWQSLDYNBF-UHFFFAOYSA-N 50548965 CHEMBL4789082::US20230365568, Compound 146 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548965&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668543 461679305 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352156 CCCn1c2nnc(SC)n2c2c(OC)cccc2c1=O InChI=1S/C14H16N4O2S/c1-4-8-17-12(19)9-6-5-7-10(20-2)11(9)18-13(17)15-16-14(18)21-3/h5-7H,4,8H2,1-3H3 LUUOYBKUMHZMOW-UHFFFAOYSA-N 50548966 CHEMBL4751005::US20230365568, Compound 147 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548966&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162651155 461679306 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51000887 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2-n2c(C)nnc12 InChI=1S/C31H43N9O2/c1-5-25-29-37-36-20(2)40(29)26-18-32-31(35-28(26)39(25)19-21-9-7-6-8-10-21)34-24-12-11-22(17-27(24)42-4)30(41)33-23-13-15-38(3)16-14-23/h11-12,17-18,21,23,25H,5-10,13-16,19H2,1-4H3,(H,33,41)(H,32,34,35)/t25-/m1/s1 QUMCIHKVKQYNPA-RUZDIDTESA-N 50551271 CHEMBL4747491 Serine/threonine-protein kinase PLK1 Homo sapiens 22 ChEMBL 10.7270/Q2PV6QK1 33616410 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551271&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 156775102 461681611 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51520168 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.7270/Q2GH9P6H 32502863 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51517503 [Br-].COc1ccc2c(c1)n(Cc1cccc(Cl)c1)c1c(C)[n+](CCCc3ccccc3)ccc21 InChI=1S/C29H28ClN2O.BrH/c1-21-29-27(15-17-31(21)16-7-11-22-8-4-3-5-9-22)26-14-13-25(33-2)19-28(26)32(29)20-23-10-6-12-24(30)18-23;/h3-6,8-10,12-15,17-19H,7,11,16,20H2,1-2H3;1H/q+1;/p-1 QORQXIOXXLTUNV-UHFFFAOYSA-M 50610756 CHEMBL5287676 Serine/threonine-protein kinase PLK1 Homo sapiens 897 ChEMBL 10.7270/Q2MK6J4R 34332400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610756&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171347851 494500504 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51517504 [Br-].Cc1[n+](Cc2ccccc2)ccc2c1n(CCCc1ccccc1)c1cc(OCc3ccc(F)cc3)ccc21 InChI=1S/C35H32FN2O.BrH/c1-26-35-33(20-22-37(26)24-28-11-6-3-7-12-28)32-19-18-31(39-25-29-14-16-30(36)17-15-29)23-34(32)38(35)21-8-13-27-9-4-2-5-10-27;/h2-7,9-12,14-20,22-23H,8,13,21,24-25H2,1H3;1H/q+1;/p-1 VAEDWPRHZUZXDX-UHFFFAOYSA-M 50610757 CHEMBL5269742 Serine/threonine-protein kinase PLK1 Homo sapiens 854 ChEMBL 10.7270/Q2MK6J4R 34332400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610757&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171343691 494500505 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51517505 [Br-].CCCCn1c2cc(OCc3ccc(F)cc3)ccc2c2cc[n+](Cc3ccccc3)c(C)c12 InChI=1S/C30H30FN2O.BrH/c1-3-4-17-33-29-19-26(34-21-24-10-12-25(31)13-11-24)14-15-27(29)28-16-18-32(22(2)30(28)33)20-23-8-6-5-7-9-23;/h5-16,18-19H,3-4,17,20-21H2,1-2H3;1H/q+1;/p-1 JGWBVGJOVYUQAZ-UHFFFAOYSA-M 50610758 CHEMBL5280383 Serine/threonine-protein kinase PLK1 Homo sapiens 310 ChEMBL 10.7270/Q2MK6J4R 34332400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610758&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171356029 494500506 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51517506 Cc1[n+](Cc2ccccc2)ccc2c1n(Cc1ccccc1)c1cc(OCc3ccccc3)ccc21 InChI=1S/C33H29N2O/c1-25-33-31(19-20-34(25)22-26-11-5-2-6-12-26)30-18-17-29(36-24-28-15-9-4-10-16-28)21-32(30)35(33)23-27-13-7-3-8-14-27/h2-21H,22-24H2,1H3/q+1 BRLRIFFHVZNKFH-UHFFFAOYSA-N 50395381 CHEMBL2164716::US9168247, JR95 Serine/threonine-protein kinase PLK1 Homo sapiens 527 ChEMBL 10.7270/Q2MK6J4R 34332400 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50395381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50395381&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 54766738 163344405 CHEMBL2164716 ZINC95556015 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352017 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 IYLBMSHZRRWSRM-FALOATQWSA-N 50426931 CHEMBL2323729::US20230365568, Compound 6a Serine/threonine-protein kinase PLK1 Homo sapiens 14740 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 42608451 164155806 CHEMBL2323729 ZINC95584623 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352018 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ccccc12 InChI=1S/C17H14N4OS/c22-15-13-8-4-5-9-14(13)21-16(18-19-17(21)23)20(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,23) VBEUIVPLCISBPO-UHFFFAOYSA-N 50548835 CHEMBL4761146::US20230365568, Compound 7 Serine/threonine-protein kinase PLK1 Homo sapiens 4380 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548835&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46507106 461679175 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352019 O=c1[nH]nc2n(CCc3ccccc3)c(=O)c3ccccc3n12 InChI=1S/C17H14N4O2/c22-15-13-8-4-5-9-14(13)21-16(18-19-17(21)23)20(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,23) KWEODWFOJBTABR-UHFFFAOYSA-N 50548836 CHEMBL4760499::US20230365568, Compound 15 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548836&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 22425028 461679176 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352020 Nc1nnc2n(CCc3ccccc3)c(=O)c3cc(F)ccc3n12 InChI=1S/C17H14FN5O/c18-12-6-7-14-13(10-12)15(24)22(17-21-20-16(19)23(14)17)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H2,19,20) KGTKDLFXVPRUKS-UHFFFAOYSA-N 50548837 CHEMBL4788810::US20230365568, Compound 16 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548837&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162669147 461679177 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352021 Cc1nnc2n(CCc3ccccc3)c(=O)c3cc(F)ccc3n12 InChI=1S/C18H15FN4O/c1-12-20-21-18-22(10-9-13-5-3-2-4-6-13)17(24)15-11-14(19)7-8-16(15)23(12)18/h2-8,11H,9-10H2,1H3 LOHAFILBHRXMKM-UHFFFAOYSA-N 50548838 CHEMBL4748102::US20230365568, Compound 17 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548838&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162650392 461679178 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352022 Fc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1nncn21 InChI=1S/C17H13FN4O/c18-13-6-7-15-14(10-13)16(23)21(17-20-19-11-22(15)17)9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2 PSUTUXIHUNZQGZ-UHFFFAOYSA-N 50548839 CHEMBL4797819::US20230365568, Compound 18 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548839&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162674902 461679179 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352023 CSc1nnc2n(CCc3ccccc3)c(=O)c3ccccc3n12 InChI=1S/C18H16N4OS/c1-24-18-20-19-17-21(12-11-13-7-3-2-4-8-13)16(23)14-9-5-6-10-15(14)22(17)18/h2-10H,11-12H2,1H3 CVZBWMNEGHUSHE-UHFFFAOYSA-N 50548840 CHEMBL4764923::US20230365568, Compound 19 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548840&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162661923 461679180 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352024 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ccccc12 InChI=1S/C17H14N4OS/c22-15-13-8-4-5-9-14(13)21-16(18-19-17(21)23)20(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,23) VBEUIVPLCISBPO-UHFFFAOYSA-N 50548835 CHEMBL4761146::US20230365568, Compound 7 Serine/threonine-protein kinase PLK1 Homo sapiens 4380 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548835&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46507106 461679175 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352025 CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C11H10N4OS/c1-2-14-9(16)7-5-3-4-6-8(7)15-10(14)12-13-11(15)17/h3-6H,2H2,1H3,(H,13,17) KRGHJDLASPDNFI-UHFFFAOYSA-N 50548841 CHEMBL4754533::US20230365568, Compound 20 Serine/threonine-protein kinase PLK1 Homo sapiens 1490 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548841&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 7064020 461679181 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352026 CCCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H12N4OS/c1-2-7-15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h3-6H,2,7H2,1H3,(H,14,18) VTEKNXCWZXDPEY-UHFFFAOYSA-N 60899 4-propyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-propyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001170914::SMR000588314::US20230365568, Compound 21::cid_2423905 Serine/threonine-protein kinase PLK1 Homo sapiens 1030 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60899&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2423905 252640127 ZINC06472729 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352027 C=CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H10N4OS/c1-2-7-15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h2-6H,1,7H2,(H,14,18) HOAFKCJEEQOECV-UHFFFAOYSA-N 80322 4-allyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-prop-2-enyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001171023::SMR000588313::US20230365568, Compound 22::cid_2363795 Serine/threonine-protein kinase PLK1 Homo sapiens 1310 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=80322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=80322&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2363795 252656961 ZINC06054423 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352028 CCCCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C13H14N4OS/c1-2-3-8-16-11(18)9-6-4-5-7-10(9)17-12(16)14-15-13(17)19/h4-7H,2-3,8H2,1H3,(H,15,19) NURBAHNZLYZFMA-UHFFFAOYSA-N 59063 4-butyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-butyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001172798::SMR000595763::US20230365568, Compound 23::cid_2120114 Serine/threonine-protein kinase PLK1 Homo sapiens 1030 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59063&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2120114 252638873 ZINC05869521 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352029 CCCCCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C14H16N4OS/c1-2-3-6-9-17-12(19)10-7-4-5-8-11(10)18-13(17)15-16-14(18)20/h4-5,7-8H,2-3,6,9H2,1H3,(H,16,20) YOCBHSHCCGTRNO-UHFFFAOYSA-N 59059 4-amyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-pentyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001171361::SMR000588310::US20230365568, Compound 24::cid_2081016 Serine/threonine-protein kinase PLK1 Homo sapiens 1970 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59059&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2081016 252638869 ZINC05866501 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352030 CC(C)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C14H16N4OS/c1-9(2)7-8-17-12(19)10-5-3-4-6-11(10)18-13(17)15-16-14(18)20/h3-6,9H,7-8H2,1-2H3,(H,16,20) CDNKKHCCJLPULM-UHFFFAOYSA-N 59062 4-(3-methylbutyl)-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-isoamyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001172777::SMR000595764::US20230365568, Compound 25::cid_2120341 Serine/threonine-protein kinase PLK1 Homo sapiens 1730 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59062&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2120341 252638872 ZINC05858788 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352031 CC(C)n1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H12N4OS/c1-7(2)15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h3-7H,1-2H3,(H,14,18) DLOSRXVROQPHNY-UHFFFAOYSA-N 50548847 CHEMBL4748147::US20230365568, Compound 26 Serine/threonine-protein kinase PLK1 Homo sapiens 1300 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548847&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649750 461679187 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352032 FC(F)(F)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H9F3N4OS/c13-12(14,15)5-6-18-9(20)7-3-1-2-4-8(7)19-10(18)16-17-11(19)21/h1-4H,5-6H2,(H,17,21) OEKJJYKFVXFNPQ-UHFFFAOYSA-N 50548848 CHEMBL4798714::US20230365568, Compound 27 Serine/threonine-protein kinase PLK1 Homo sapiens 1250 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548848&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162676007 461679188 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352033 COCCCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C13H14N4O2S/c1-19-8-4-7-16-11(18)9-5-2-3-6-10(9)17-12(16)14-15-13(17)20/h2-3,5-6H,4,7-8H2,1H3,(H,15,20) FGOFGESTKFLRBZ-UHFFFAOYSA-N 60900 4-(3-methoxypropyl)-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-(3-methoxypropyl)-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001171363::SMR000588311::US20230365568, Compound 28::cid_2081017 Serine/threonine-protein kinase PLK1 Homo sapiens 1750 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60900&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2081017 252640128 ZINC05894211 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352034 CCOCCCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C14H16N4O2S/c1-2-20-9-5-8-17-12(19)10-6-3-4-7-11(10)18-13(17)15-16-14(18)21/h3-4,6-7H,2,5,8-9H2,1H3,(H,16,21) IWTGZWFZSRRECN-UHFFFAOYSA-N 80321 4-(3-ethoxypropyl)-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-(3-ethoxypropyl)-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001175342::SMR000588309::US20230365568, Compound 29::cid_2110924 Serine/threonine-protein kinase PLK1 Homo sapiens 1680 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=80321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=80321&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2110924 252656960 ZINC05931037 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352035 CCC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O 50548851 CHEMBL4757529::US20230365568, Compound 30 Serine/threonine-protein kinase PLK1 Homo sapiens 3230 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548851&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743362 461679191 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352036 CC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C15H17N5O2S/c1-9(2)16-12(21)7-8-19-13(22)10-5-3-4-6-11(10)20-14(19)17-18-15(20)23/h3-6,9H,7-8H2,1-2H3,(H,16,21)(H,18,23) YATBHHZNVXTYJO-UHFFFAOYSA-N 50548852 CHEMBL4795383::US20230365568, Compound 31 Serine/threonine-protein kinase PLK1 Homo sapiens 3900 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548852&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743374 461679192 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352037 CC(C)CNC(=O)CCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C16H19N5O2S/c1-10(2)9-17-13(22)7-8-20-14(23)11-5-3-4-6-12(11)21-15(20)18-19-16(21)24/h3-6,10H,7-9H2,1-2H3,(H,17,22)(H,19,24) USTNJZLAIQFDOY-UHFFFAOYSA-N 50548853 CHEMBL4760714::US20230365568, Compound 32 Serine/threonine-protein kinase PLK1 Homo sapiens 2920 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548853&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743424 461679193 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352038 Cc1cccc(c1C)-n1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C17H14N4OS/c1-10-6-5-9-13(11(10)2)20-15(22)12-7-3-4-8-14(12)21-16(20)18-19-17(21)23/h3-9H,1-2H3,(H,19,23) BLZLSOAYWCNFDM-UHFFFAOYSA-N 636552 US20230365568, Compound 33 Serine/threonine-protein kinase PLK1 Homo sapiens 1850 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=636552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=636552&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352039 Fc1ccc(Cn2c3n[nH]c(=S)n3c3ccccc3c2=O)cc1 InChI=1S/C16H11FN4OS/c17-11-7-5-10(6-8-11)9-20-14(22)12-3-1-2-4-13(12)21-15(20)18-19-16(21)23/h1-8H,9H2,(H,19,23) OIYNRKLWHMUQSO-UHFFFAOYSA-N 50548855 CHEMBL4781514::US20230365568, Compound 34 Serine/threonine-protein kinase PLK1 Homo sapiens 3540 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548855&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2384603 461679195 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352040 CCCn1c2n[nH]c(=S)n2c2ccccc2c1=O InChI=1S/C12H12N4OS/c1-2-7-15-10(17)8-5-3-4-6-9(8)16-11(15)13-14-12(16)18/h3-6H,2,7H2,1H3,(H,14,18) VTEKNXCWZXDPEY-UHFFFAOYSA-N 60899 4-propyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::4-propyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one::MLS001170914::SMR000588314::US20230365568, Compound 21::cid_2423905 Serine/threonine-protein kinase PLK1 Homo sapiens 1030 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60899&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 2423905 252640127 ZINC06472729 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352041 CCCn1c2nn(CN(C)C3CC3)c(=S)n2c2ccccc2c1=O InChI=1S/C17H21N5OS/c1-3-10-20-15(23)13-6-4-5-7-14(13)22-16(20)18-21(17(22)24)11-19(2)12-8-9-12/h4-7,12H,3,8-11H2,1-2H3 NJIIJHDNOJRNIC-UHFFFAOYSA-N 50548856 CHEMBL4745057::US20230365568, Compound 35 Serine/threonine-protein kinase PLK1 Homo sapiens 1630 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548856&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137977962 461679196 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352042 CCCN(C)Cn1nc2n(C)c(=O)c3ccccc3n2c1=S InChI=1S/C15H19N5OS/c1-4-9-17(2)10-19-15(22)20-12-8-6-5-7-11(12)13(21)18(3)14(20)16-19/h5-8H,4,9-10H2,1-3H3 ARVXSSVHBIIKPE-UHFFFAOYSA-N 50548857 CHEMBL4797816::US20230365568, Compound 36 Serine/threonine-protein kinase PLK1 Homo sapiens 1200 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548857&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137979186 461679197 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352043 CCCN(C)Cn1nc2n(CCC)c(=O)c3ccccc3n2c1=S InChI=1S/C17H23N5OS/c1-4-10-19(3)12-21-17(24)22-14-9-7-6-8-13(14)15(23)20(11-5-2)16(22)18-21/h6-9H,4-5,10-12H2,1-3H3 WIZPROBUTYPMHD-UHFFFAOYSA-N 50548858 CHEMBL4785390::US20230365568, Compound 37 Serine/threonine-protein kinase PLK1 Homo sapiens 1830 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548858&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 137979187 461679198 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352044 CCCn1c2nn(CN(CC)CC(C)C)c(=S)n2c2ccccc2c1=O InChI=1S/C19H27N5OS/c1-5-11-22-17(25)15-9-7-8-10-16(15)24-18(22)20-23(19(24)26)13-21(6-2)12-14(3)4/h7-10,14H,5-6,11-13H2,1-4H3 HQCMGJVLKBTUAL-UHFFFAOYSA-N 636557 US20230365568, Compound 38 Serine/threonine-protein kinase PLK1 Homo sapiens 1670 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=636557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=636557&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352045 CCCn1c2nn(CC(=O)c3ccccc3)c(=S)n2c2ccccc2c1=O InChI=1S/C20H18N4O2S/c1-2-12-22-18(26)15-10-6-7-11-16(15)24-19(22)21-23(20(24)27)13-17(25)14-8-4-3-5-9-14/h3-11H,2,12-13H2,1H3 VEIFQCWXUBNKKM-UHFFFAOYSA-N 50548860 CHEMBL4777333::US20230365568, Compound 39 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548860&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162643629 461679200 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352046 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ccccc12 InChI=1S/C17H14N4OS/c22-15-13-8-4-5-9-14(13)21-16(18-19-17(21)23)20(15)11-10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,23) VBEUIVPLCISBPO-UHFFFAOYSA-N 50548835 CHEMBL4761146::US20230365568, Compound 7 Serine/threonine-protein kinase PLK1 Homo sapiens 4380 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548835&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46507106 461679175 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352047 Fc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C17H13FN4OS/c18-12-6-7-14-13(10-12)15(23)21(16-19-20-17(24)22(14)16)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) PWVRMPWRONITRC-UHFFFAOYSA-N 50548861 CHEMBL4760240::US20230365568, Compound 40 Serine/threonine-protein kinase PLK1 Homo sapiens 12920 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548861&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657514 461679201 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352048 Brc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C17H13BrN4OS/c18-12-6-7-14-13(10-12)15(23)21(16-19-20-17(24)22(14)16)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) POJBEZPPFIPGTF-UHFFFAOYSA-N 50548862 CHEMBL4763203::US20230365568, Compound 41 Serine/threonine-protein kinase PLK1 Homo sapiens 14740 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548862&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162660378 461679202 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352049 Ic1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C17H13IN4OS/c18-12-6-7-14-13(10-12)15(23)21(16-19-20-17(24)22(14)16)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) BQMIJZVLKIKAQJ-UHFFFAOYSA-N 50548863 CHEMBL4740835::US20230365568, Compound 42 Serine/threonine-protein kinase PLK1 Homo sapiens 30710 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548863&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644682 461679203 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352050 Cc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C18H16N4OS/c1-12-7-8-15-14(11-12)16(23)21(17-19-20-18(24)22(15)17)10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,20,24) GNEWVHKRNDFJCE-UHFFFAOYSA-N 50548864 CHEMBL4781557::US20230365568, Compound 43 Serine/threonine-protein kinase PLK1 Homo sapiens 11290 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548864&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664240 461679204 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352051 CC(=O)Nc1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C19H17N5O2S/c1-12(25)20-14-7-8-16-15(11-14)17(26)23(18-21-22-19(27)24(16)18)10-9-13-5-3-2-4-6-13/h2-8,11H,9-10H2,1H3,(H,20,25)(H,22,27) WXOJSKLCQUJIFR-UHFFFAOYSA-N 50548865 CHEMBL4790284::US20230365568, Compound 44 Serine/threonine-protein kinase PLK1 Homo sapiens 2190 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548865&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162670193 461679205 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352052 CN(C)c1ccc2c(c1)c(=O)n(CCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C19H19N5OS/c1-22(2)14-8-9-16-15(12-14)17(25)23(18-20-21-19(26)24(16)18)11-10-13-6-4-3-5-7-13/h3-9,12H,10-11H2,1-2H3,(H,21,26) DSIFZPYEFYGDGH-UHFFFAOYSA-N 50548866 CHEMBL4778039::US20230365568, Compound 45 Serine/threonine-protein kinase PLK1 Homo sapiens 2770 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548866&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162644184 461679206 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352053 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ccc(cc12)N1CCOCC1 InChI=1S/C21H21N5O2S/c27-19-17-14-16(24-10-12-28-13-11-24)6-7-18(17)26-20(22-23-21(26)29)25(19)9-8-15-4-2-1-3-5-15/h1-7,14H,8-13H2,(H,23,29) NZDUPSXPEXBPQQ-UHFFFAOYSA-N 50548867 CHEMBL4794319::US20230365568, Compound 46 Serine/threonine-protein kinase PLK1 Homo sapiens 1540 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548867&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162673177 461679207 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352054 Fc1ccc2c(c1)n1c(n[nH]c1=S)n(CCc1ccccc1)c2=O InChI=1S/C17H13FN4OS/c18-12-6-7-13-14(10-12)22-16(19-20-17(22)24)21(15(13)23)9-8-11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,24) ARXNISBPPXAEET-UHFFFAOYSA-N 50548868 CHEMBL4790198::US20230365568, Compound 47 Serine/threonine-protein kinase PLK1 Homo sapiens 8290 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548868&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668950 461679208 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352055 Fc1cccc2c1n1c(n[nH]c1=S)n(CCc1ccccc1)c2=O InChI=1S/C17H13FN4OS/c18-13-8-4-7-12-14(13)22-16(19-20-17(22)24)21(15(12)23)10-9-11-5-2-1-3-6-11/h1-8H,9-10H2,(H,20,24) GXFFIIRYUDXYSJ-UHFFFAOYSA-N 50548869 CHEMBL4753929::US20230365568, Compound 48 Serine/threonine-protein kinase PLK1 Homo sapiens 2580 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548869&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654287 461679209 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352056 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2cccnc12 InChI=1S/C16H13N5OS/c22-14-13-12(7-4-9-17-13)21-15(18-19-16(21)23)20(14)10-8-11-5-2-1-3-6-11/h1-7,9H,8,10H2,(H,19,23) UNXSVXQBBSODJB-UHFFFAOYSA-N 50548870 CHEMBL4748954::US20230365568, Compound 49 Serine/threonine-protein kinase PLK1 Homo sapiens 6160 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548870&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649280 461679210 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352057 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2cnccc12 InChI=1S/C16H13N5OS/c22-14-12-6-8-17-10-13(12)21-15(18-19-16(21)23)20(14)9-7-11-4-2-1-3-5-11/h1-6,8,10H,7,9H2,(H,19,23) CRBAQEJPOKUWAO-UHFFFAOYSA-N 50548871 CHEMBL4761255::US20230365568, Compound 50 Serine/threonine-protein kinase PLK1 Homo sapiens 27780 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548871&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659833 461679211 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352058 O=c1n(CCc2ccccc2)c2n[nH]c(=S)n2c2ncccc12 InChI=1S/C16H13N5OS/c22-14-12-7-4-9-17-13(12)21-15(18-19-16(21)23)20(14)10-8-11-5-2-1-3-6-11/h1-7,9H,8,10H2,(H,19,23) YQVFVYPOJDIQNU-UHFFFAOYSA-N 50548872 CHEMBL4785169::US20230365568, Compound 51 Serine/threonine-protein kinase PLK1 Homo sapiens 7550 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548872&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162666285 461679212 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352059 Fc1ccc2c(c1)c(=O)n(Cc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C16H11FN4OS/c17-11-6-7-13-12(8-11)14(22)20(9-10-4-2-1-3-5-10)15-18-19-16(23)21(13)15/h1-8H,9H2,(H,19,23) VIGACJGWPVPHBB-UHFFFAOYSA-N 50548873 CHEMBL4742355::US20230365568, Compound 52 Serine/threonine-protein kinase PLK1 Homo sapiens 6420 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548873&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646713 461679213 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352060 Fc1ccc2c(c1)c(=O)n(CCCc1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C18H15FN4OS/c19-13-8-9-15-14(11-13)16(24)22(17-20-21-18(25)23(15)17)10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11H,4,7,10H2,(H,21,25) YVYISAUWEDGFCH-UHFFFAOYSA-N 50548874 CHEMBL4782336::US20230365568, Compound 53 Serine/threonine-protein kinase PLK1 Homo sapiens 6630 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548874&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162664618 461679214 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352061 CCCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C12H11ClN4OS/c1-2-5-16-10(18)8-6-7(13)3-4-9(8)17-11(16)14-15-12(17)19/h3-4,6H,2,5H2,1H3,(H,15,19) HXJVZTMGWRDKKD-UHFFFAOYSA-N 50548875 CHEMBL4784212::US20230365568, Compound 54 Serine/threonine-protein kinase PLK1 Homo sapiens 1770 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548875&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743387 461679215 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352062 FC(F)(F)CCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C12H8ClF3N4OS/c13-6-1-2-8-7(5-6)9(21)19(4-3-12(14,15)16)10-17-18-11(22)20(8)10/h1-2,5H,3-4H2,(H,18,22) FRGSZPKQZLHMCL-UHFFFAOYSA-N 50548876 CHEMBL4758856::US20230365568, Compound 55 Serine/threonine-protein kinase PLK1 Homo sapiens 2140 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548876&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162657854 461679216 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352063 CC(C)OCCCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C15H17ClN4O2S/c1-9(2)22-7-3-6-19-13(21)11-8-10(16)4-5-12(11)20-14(19)17-18-15(20)23/h4-5,8-9H,3,6-7H2,1-2H3,(H,18,23) XQVTWTZOKDBSJM-UHFFFAOYSA-N 50548877 CHEMBL4756416::US20230365568, Compound 56 Serine/threonine-protein kinase PLK1 Homo sapiens 1620 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548877&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743388 461679217 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352064 CC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccc(Cl)cc2c1=O InChI=1S/C15H16ClN5O2S/c1-8(2)17-12(22)5-6-20-13(23)10-7-9(16)3-4-11(10)21-14(20)18-19-15(21)24/h3-4,7-8H,5-6H2,1-2H3,(H,17,22)(H,19,24) XCCDPANCNAOECG-UHFFFAOYSA-N 50548878 CHEMBL4746990::US20230365568, Compound 57 Serine/threonine-protein kinase PLK1 Homo sapiens 1490 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548878&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743373 461679218 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352065 CC(C)NC(=O)CCn1c2n[nH]c(=S)n2c2ccc(C)cc2c1=O InChI=1S/C16H19N5O2S/c1-9(2)17-13(22)6-7-20-14(23)11-8-10(3)4-5-12(11)21-15(20)18-19-16(21)24/h4-5,8-9H,6-7H2,1-3H3,(H,17,22)(H,19,24) OPXAZSSKPXNTRH-UHFFFAOYSA-N 50548879 CHEMBL4740867::US20230365568, Compound 58 Serine/threonine-protein kinase PLK1 Homo sapiens 2010 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548879&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743425 461679219 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352066 CCCn1c2n[nH]c(=S)n2c2cc(ccc2c1=O)C(=O)NC(C)C InChI=1S/C16H19N5O2S/c1-4-7-20-14(23)11-6-5-10(13(22)17-9(2)3)8-12(11)21-15(20)18-19-16(21)24/h5-6,8-9H,4,7H2,1-3H3,(H,17,22)(H,19,24) ZKOYITQVZRJHGZ-UHFFFAOYSA-N 50548880 CHEMBL4754153::US20230365568, Compound 59 Serine/threonine-protein kinase PLK1 Homo sapiens 3010 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548880&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743123 461679220 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352067 CC(C)CCn1c2n[nH]c(=S)n2c2cc(ccc2c1=O)C(=O)NC1CCCC1 InChI=1S/C20H25N5O2S/c1-12(2)9-10-24-18(27)15-8-7-13(17(26)21-14-5-3-4-6-14)11-16(15)25-19(24)22-23-20(25)28/h7-8,11-12,14H,3-6,9-10H2,1-2H3,(H,21,26)(H,23,28) HNGRKHKTYDCKHH-UHFFFAOYSA-N 50548881 CHEMBL4551650::US20230365568, Compound 60 Serine/threonine-protein kinase PLK1 Homo sapiens 11110 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548881&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 46507130 461679221 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352068 Cn1c2n[nH]c(=S)n2c2cc(ccc2c1=O)C(=O)NC1CCCC1 InChI=1S/C16H17N5O2S/c1-20-14(23)11-7-6-9(13(22)17-10-4-2-3-5-10)8-12(11)21-15(20)18-19-16(21)24/h6-8,10H,2-5H2,1H3,(H,17,22)(H,19,24) RHGIGRMBINVXCT-UHFFFAOYSA-N 50548882 CHEMBL4778744::US20230365568, Compound 61 Serine/threonine-protein kinase PLK1 Homo sapiens 2750 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548882&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743088 461679222 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352069 CNC(=S)N1CN(CCc2ccccc2)C(=O)c2cc(F)ccc12 InChI=1S/C18H18FN3OS/c1-20-18(24)22-12-21(10-9-13-5-3-2-4-6-13)17(23)15-11-14(19)7-8-16(15)22/h2-8,11H,9-10,12H2,1H3,(H,20,24) WVLYQUZMHQKAFJ-UHFFFAOYSA-N 50548883 CHEMBL4761200::US20230365568, Compound 62 Serine/threonine-protein kinase PLK1 Homo sapiens >50000 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548883&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162659178 461679223 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352070 CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C11H9FN4OS/c1-2-15-9(17)7-5-6(12)3-4-8(7)16-10(15)13-14-11(16)18/h3-5H,2H2,1H3,(H,14,18) ZFZIUCSCTPUEMS-UHFFFAOYSA-N 50548884 CHEMBL4751837::US20230365568, Compound 63 Serine/threonine-protein kinase PLK1 Homo sapiens 1980 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548884&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652827 461679224 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352071 CCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H11FN4OS/c1-2-5-16-10(18)8-6-7(13)3-4-9(8)17-11(16)14-15-12(17)19/h3-4,6H,2,5H2,1H3,(H,15,19) ICNXHKBTCLSKNU-UHFFFAOYSA-N 50548885 CHEMBL4793697::US20230365568, Compound 64 Serine/threonine-protein kinase PLK1 Homo sapiens 1160 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548885&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 50743203 461679225 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352072 Fc1ccc2c(c1)c(=O)n(CCC(F)(F)F)c1n[nH]c(=S)n21 InChI=1S/C12H8F4N4OS/c13-6-1-2-8-7(5-6)9(21)19(4-3-12(14,15)16)10-17-18-11(22)20(8)10/h1-2,5H,3-4H2,(H,18,22) KQLVCCQCJZYYBX-UHFFFAOYSA-N 50548886 CHEMBL4755597::US20230365568, Compound 65 Serine/threonine-protein kinase PLK1 Homo sapiens 750 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548886&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655125 461679226 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352073 OCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H11FN4O2S/c13-7-2-3-9-8(6-7)10(19)16(4-1-5-18)11-14-15-12(20)17(9)11/h2-3,6,18H,1,4-5H2,(H,15,20) BKPWWWIXOIQUCN-UHFFFAOYSA-N 50548887 CHEMBL4745372::US20230365568, Compound 66 Serine/threonine-protein kinase PLK1 Homo sapiens 1440 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548887&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162647557 461679227 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352074 NCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C11H10FN5OS/c12-6-1-2-8-7(5-6)9(18)16(4-3-13)10-14-15-11(19)17(8)10/h1-2,5H,3-4,13H2,(H,15,19) GGOPLEZJCSAANI-UHFFFAOYSA-N 50548888 CHEMBL4751497::US20230365568, Compound 67 Serine/threonine-protein kinase PLK1 Homo sapiens 4330 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548888&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162652031 461679228 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352075 NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H12FN5OS/c13-7-2-3-9-8(6-7)10(19)17(5-1-4-14)11-15-16-12(20)18(9)11/h2-3,6H,1,4-5,14H2,(H,16,20) NHKMVUTYRNAGOV-UHFFFAOYSA-N 50548889 CHEMBL4754906::US20230365568, Compound 68 Serine/threonine-protein kinase PLK1 Homo sapiens 2260 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548889&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162654616 461679229 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352076 NCCCn1c2n[nH]c(=S)n2c2c(F)cccc2c1=O InChI=1S/C12H12FN5OS/c13-8-4-1-3-7-9(8)18-11(15-16-12(18)20)17(10(7)19)6-2-5-14/h1,3-4H,2,5-6,14H2,(H,16,20) KJVKMIZOPMZUQR-UHFFFAOYSA-N 50548890 CHEMBL4755386::US20230365568, Compound 69 Serine/threonine-protein kinase PLK1 Homo sapiens 5070 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548890&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655710 461679230 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352077 CN(C)CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C13H14FN5OS/c1-17(2)5-6-18-11(20)9-7-8(14)3-4-10(9)19-12(18)15-16-13(19)21/h3-4,7H,5-6H2,1-2H3,(H,16,21) ITFZJFPHTIDQPE-UHFFFAOYSA-N 50548891 CHEMBL4747805::US20230365568, Compound 70 Serine/threonine-protein kinase PLK1 Homo sapiens 2450 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548891&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162649964 461679231 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352078 CC(CN(C)C)n1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O 50548892 CHEMBL4789908::US20230365568, Compound 71 Serine/threonine-protein kinase PLK1 Homo sapiens 6120 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548892&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162668802 461679232 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352079 CC(=O)NCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C13H12FN5O2S/c1-7(20)15-4-5-18-11(21)9-6-8(14)2-3-10(9)19-12(18)16-17-13(19)22/h2-3,6H,4-5H2,1H3,(H,15,20)(H,17,22) FFZWMMMZSQJIJZ-UHFFFAOYSA-N 50548893 CHEMBL4781312::US20230365568, Compound 72 Serine/threonine-protein kinase PLK1 Homo sapiens 2480 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548893&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162663909 461679233 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352080 CC(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C14H14FN5O2S/c1-8(21)16-5-2-6-19-12(22)10-7-9(15)3-4-11(10)20-13(19)17-18-14(20)23/h3-4,7H,2,5-6H2,1H3,(H,16,21)(H,18,23) FLXWQNVFPVCGCV-UHFFFAOYSA-N 50548894 CHEMBL4764140::US20230365568, Compound 73 Serine/threonine-protein kinase PLK1 Homo sapiens 2480 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548894&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162662104 461679234 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352081 Fc1ccc2c(c1)c(=O)n(CCCNC(=O)c1ccccc1)c1n[nH]c(=S)n21 InChI=1S/C19H16FN5O2S/c20-13-7-8-15-14(11-13)17(27)24(18-22-23-19(28)25(15)18)10-4-9-21-16(26)12-5-2-1-3-6-12/h1-3,5-8,11H,4,9-10H2,(H,21,26)(H,23,28) PCCMTSCTMOZUIS-UHFFFAOYSA-N 50548895 CHEMBL4741656::US20230365568, Compound 74 Serine/threonine-protein kinase PLK1 Homo sapiens 1600 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548895&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162646105 461679235 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352082 CS(=O)(=O)NCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C12H12FN5O3S2/c1-23(20,21)14-4-5-17-10(19)8-6-7(13)2-3-9(8)18-11(17)15-16-12(18)22/h2-3,6,14H,4-5H2,1H3,(H,16,22) XJJUWPYFFRPMAK-UHFFFAOYSA-N 50548896 CHEMBL4795189::US20230365568, Compound 75 Serine/threonine-protein kinase PLK1 Homo sapiens 2770 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548896&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162672902 461679236 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352083 CS(=O)(=O)NCCCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C13H14FN5O3S2/c1-24(21,22)15-5-2-6-18-11(20)9-7-8(14)3-4-10(9)19-12(18)16-17-13(19)23/h3-4,7,15H,2,5-6H2,1H3,(H,17,23) RGJQYWGBXSGTJP-UHFFFAOYSA-N 50548897 CHEMBL4744283::US20230365568, Compound 76 Serine/threonine-protein kinase PLK1 Homo sapiens 1870 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548897&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162645881 461679237 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1352084 OP(O)(=O)CCn1c2n[nH]c(=S)n2c2ccc(F)cc2c1=O InChI=1S/C11H10FN4O4PS/c12-6-1-2-8-7(5-6)9(17)15(3-4-21(18,19)20)10-13-14-11(22)16(8)10/h1-2,5H,3-4H2,(H,14,22)(H2,18,19,20) KTUNLJXBRLDWKB-UHFFFAOYSA-N 50548898 CHEMBL4755932::US20230365568, Compound 77 Serine/threonine-protein kinase PLK1 Homo sapiens 21700 US Patent 10.7270/Q20Z77FN US20230365568 Lee, KS; Jacobson, KA; Alverez, CN; Park, J; Oliva, P; Lee, H; Pongorne Kirsch, K The United States Of America,As Represented By The Secretary,Department Of Health And Human Services http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548898&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 162655609 461679238 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 1Q4K,1Q4O,1UMW,2OGQ,2OJX,2V5Q,2YAC,3BZI,3C5L,3HIH,3HIK,3KB7,3P2W,3P2Z,3P34,3P35,3P36,3P37,3Q1I,4A4L,4A4O,4DFW,4E67,4E9C,4E9D,4H5X,4H71,4HAB,4HCO,4HY2,4J52,4J53,4LKL,4LKM,4O56,4O9W,4RCP,5NN2,6GY2,8JOQ,8JOY Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408006 CSc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 InChI=1S/C24H25F3N6O2S2/c1-32-7-9-33(10-8-32)14-4-6-17(35-24(25,26)27)16(11-14)30-23-29-12-13-3-5-15-18(19(13)31-23)22(36-2)37-20(15)21(28)34/h4,6,11-12H,3,5,7-10H2,1-2H3,(H2,28,34)(H,29,30,31) VGKJUXZAFATSHY-UHFFFAOYSA-N 670917 US20240140962, Compound 1 Serine/threonine-protein kinase PLK1 Homo sapiens 4.40 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670917&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449944 497614831 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408007 CCOc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 InChI=1S/C25H27F3N6O3S/c1-3-36-23-19-16(21(38-23)22(29)35)6-4-14-13-30-24(32-20(14)19)31-17-12-15(34-10-8-33(2)9-11-34)5-7-18(17)37-25(26,27)28/h5,7,12-13H,3-4,6,8-11H2,1-2H3,(H2,29,35)(H,30,31,32) DHIIWXVDVHSSFP-UHFFFAOYSA-N 670918 US20240140962, Compound 2 Serine/threonine-protein kinase PLK1 Homo sapiens 4.20 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670918&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449945 497614832 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408008 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(sc(SCCO)c4-c3n2)C(N)=O)c1 InChI=1S/C25H27F3N6O3S2/c1-33-6-8-34(9-7-33)15-3-5-18(37-25(26,27)28)17(12-15)31-24-30-13-14-2-4-16-19(20(14)32-24)23(38-11-10-35)39-21(16)22(29)36/h3,5,12-13,35H,2,4,6-11H2,1H3,(H2,29,36)(H,30,31,32) PJPPHIPVHJDBFW-UHFFFAOYSA-N 670919 US20240140962, Compound 3 Serine/threonine-protein kinase PLK1 Homo sapiens 5.00 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670919&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449943 497614833 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408009 CSc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)F)N4CCN(C)CC4)nc3-c12 InChI=1S/C24H26F2N6O2S2/c1-31-7-9-32(10-8-31)14-4-6-17(34-23(25)26)16(11-14)29-24-28-12-13-3-5-15-18(19(13)30-24)22(35-2)36-20(15)21(27)33/h4,6,11-12,23H,3,5,7-10H2,1-2H3,(H2,27,33)(H,28,29,30) WZZWNQOPEJWQJA-UHFFFAOYSA-N 670920 US20240140962, Compound 4 Serine/threonine-protein kinase PLK1 Homo sapiens 1.000 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670920&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449948 497614834 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408010 CSc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ncc4OC(F)(F)F)N4CCN(C)CC4)nc3-c12 InChI=1S/C23H24F3N7O2S2/c1-32-5-7-33(8-6-32)16-9-14(15(11-28-16)35-23(24,25)26)30-22-29-10-12-3-4-13-17(18(12)31-22)21(36-2)37-19(13)20(27)34/h9-11H,3-8H2,1-2H3,(H2,27,34)(H,28,29,30,31) FPFVTAQELGPTOP-UHFFFAOYSA-N 670921 US20240140962, Compound 5 Serine/threonine-protein kinase PLK1 Homo sapiens 2.60 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670921&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449949 497614835 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408011 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(sc(CCO)c4-c3n2)C(N)=O)c1 InChI=1S/C25H27F3N6O3S/c1-33-7-9-34(10-8-33)15-3-5-18(37-25(26,27)28)17(12-15)31-24-30-13-14-2-4-16-20(21(14)32-24)19(6-11-35)38-22(16)23(29)36/h3,5,12-13,35H,2,4,6-11H2,1H3,(H2,29,36)(H,30,31,32) QYBMNLBGLNBFDE-UHFFFAOYSA-N 670922 US20240140962, Compound 6 Serine/threonine-protein kinase PLK1 Homo sapiens 6.90 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670922&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449950 497614836 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408012 CSc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCNCC4)nc3-c12 InChI=1S/C23H23F3N6O2S2/c1-35-21-17-14(19(36-21)20(27)33)4-2-12-11-29-22(31-18(12)17)30-15-10-13(32-8-6-28-7-9-32)3-5-16(15)34-23(24,25)26/h3,5,10-11,28H,2,4,6-9H2,1H3,(H2,27,33)(H,29,30,31) OJGYDTTULCJADJ-UHFFFAOYSA-N 670923 US20240140962, Compound 7 Serine/threonine-protein kinase PLK1 Homo sapiens 3.00 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670923&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449951 497614837 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408013 CSc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(CCO)CC4)nc3-c12 InChI=1S/C25H27F3N6O3S2/c1-38-23-19-16(21(39-23)22(29)36)4-2-14-13-30-24(32-20(14)19)31-17-12-15(3-5-18(17)37-25(26,27)28)34-8-6-33(7-9-34)10-11-35/h3,5,12-13,35H,2,4,6-11H2,1H3,(H2,29,36)(H,30,31,32) UTGDSWVHKOMDIY-UHFFFAOYSA-N 670924 US20240140962, Compound 8 Serine/threonine-protein kinase PLK1 Homo sapiens 1.70 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670924&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449952 497614838 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408014 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(csc4C(N)=O)-c3n2)c1 InChI=1S/C23H23F3N6O2S/c1-31-6-8-32(9-7-31)14-3-5-18(34-23(24,25)26)17(10-14)29-22-28-11-13-2-4-15-16(19(13)30-22)12-35-20(15)21(27)33/h3,5,10-12H,2,4,6-9H2,1H3,(H2,27,33)(H,28,29,30) DQFWBLRUHLAWNX-UHFFFAOYSA-N 670925 US20240140962, Compound 12 Serine/threonine-protein kinase PLK1 Homo sapiens 4.00 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670925&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449956 497614839 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408015 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(sc(C#N)c4-c3n2)C(N)=O)c1 InChI=1S/C24H22F3N7O2S/c1-33-6-8-34(9-7-33)14-3-5-17(36-24(25,26)27)16(10-14)31-23-30-12-13-2-4-15-19(20(13)32-23)18(11-28)37-21(15)22(29)35/h3,5,10,12H,2,4,6-9H2,1H3,(H2,29,35)(H,30,31,32) BDFJYUDIBMNFGN-UHFFFAOYSA-N 670926 US20240140962, Compound 13 Serine/threonine-protein kinase PLK1 Homo sapiens 4.90 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670926&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449958 497614840 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408016 CSc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CCN(C)CC4=O)nc3-c12 InChI=1S/C24H23F3N6O3S2/c1-32-7-8-33(17(34)11-32)13-4-6-16(36-24(25,26)27)15(9-13)30-23-29-10-12-3-5-14-18(19(12)31-23)22(37-2)38-20(14)21(28)35/h4,6,9-10H,3,5,7-8,11H2,1-2H3,(H2,28,35)(H,29,30,31) MYDITIAJVIXKIB-UHFFFAOYSA-N 670927 US20240140962, Compound 14 Serine/threonine-protein kinase PLK1 Homo sapiens 7.30 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670927&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 171457471 497614841 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408017 CSc1sc(C(N)=O)c2CCc3cnc(Nc4cc(ccc4OC(F)(F)F)N4CC5CC(C4)N5C)nc3-c12 InChI=1S/C25H25F3N6O2S2/c1-33-14-7-15(33)11-34(10-14)13-4-6-18(36-25(26,27)28)17(8-13)31-24-30-9-12-3-5-16-19(20(12)32-24)23(37-2)38-21(16)22(29)35/h4,6,8-9,14-15H,3,5,7,10-11H2,1-2H3,(H2,29,35)(H,30,31,32) HMXUENSKKHECGP-UHFFFAOYSA-N 670928 US20240140962, Compound 15 Serine/threonine-protein kinase PLK1 Homo sapiens 6.40 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670928&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449964 497614842 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408018 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(sc(C5CC5)c4-c3n2)C(N)=O)c1 InChI=1S/C26H27F3N6O2S/c1-34-8-10-35(11-9-34)16-5-7-19(37-26(27,28)29)18(12-16)32-25-31-13-15-4-6-17-20(21(15)33-25)22(14-2-3-14)38-23(17)24(30)36/h5,7,12-14H,2-4,6,8-11H2,1H3,(H2,30,36)(H,31,32,33) YJINJATWDYHJHD-UHFFFAOYSA-N 670929 US20240140962, Compound 16 Serine/threonine-protein kinase PLK1 Homo sapiens 5.30 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670929&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449966 497614843 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408019 COc1nnc(cc1Nc1ncc2CCc3c(sc(SC)c3-c2n1)C(N)=O)N1CCN(C)CC1 InChI=1S/C22H26N8O2S2/c1-29-6-8-30(9-7-29)15-10-14(20(32-2)28-27-15)25-22-24-11-12-4-5-13-16(17(12)26-22)21(33-3)34-18(13)19(23)31/h10-11H,4-9H2,1-3H3,(H2,23,31)(H,24,25,26,27) UCFVSPILGPQERS-UHFFFAOYSA-N 670930 US20240140962, Compound 17 Serine/threonine-protein kinase PLK1 Homo sapiens 5.90 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670930&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449967 497614844 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408020 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(sc(OC5CC5)c4-c3n2)C(N)=O)c1 InChI=1S/C26H27F3N6O3S/c1-34-8-10-35(11-9-34)15-3-7-19(38-26(27,28)29)18(12-15)32-25-31-13-14-2-6-17-20(21(14)33-25)24(37-16-4-5-16)39-22(17)23(30)36/h3,7,12-13,16H,2,4-6,8-11H2,1H3,(H2,30,36)(H,31,32,33) UKLJTKLVJSTQBL-UHFFFAOYSA-N 670931 US20240140962, Compound 18 Serine/threonine-protein kinase PLK1 Homo sapiens 4.30 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670931&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449968 497614845 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 1408021 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(sc(-c5ccco5)c4-c3n2)C(N)=O)c1 InChI=1S/C27H25F3N6O3S/c1-35-8-10-36(11-9-35)16-5-7-19(39-27(28,29)30)18(13-16)33-26-32-14-15-4-6-17-21(22(15)34-26)24(20-3-2-12-38-20)40-23(17)25(31)37/h2-3,5,7,12-14H,4,6,8-11H2,1H3,(H2,31,37)(H,32,33,34) NPQQFSMPJDNETI-UHFFFAOYSA-N 670932 US20240140962, Compound 20 Serine/threonine-protein kinase PLK1 Homo sapiens 2.80 US Patent 10.7270/Q2C53R57 US20240140962 XU, Y; WU, W; TAN, H; ZAHNG, D; SUN, J; ZHANG, Y; CHEN, S Medshine Discovery http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=670932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=670932&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 170449972 497614846 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56 Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544063 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN(CC)CC)ncc2N(C)C1=O InChI=1S/C29H41N7O3/c1-6-22-28(38)33(4)24-17-30-29(32-27(24)36(22)20-11-9-10-12-20)31-21-16-23-19(15-25(21)39-5)13-14-35(23)26(37)18-34(7-2)8-3/h15-17,20,22H,6-14,18H2,1-5H3,(H,30,31,32)/t22-/m1/s1 ZANSQRVTKCXEOP-JOCHJYFZSA-N 50621052 CHEMBL5434467 Serine/threonine-protein kinase PLK1 Homo sapiens 7.8 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621052&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544064 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCCC3)ncc2N(C)C1=O InChI=1S/C29H39N7O3/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-9-5-6-10-20)31-21-16-23-19(15-25(21)39-3)11-14-35(23)26(37)18-34-12-7-8-13-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 NLLBMFZASOCLIF-JOCHJYFZSA-N 50621053 CHEMBL5408583 Serine/threonine-protein kinase PLK1 Homo sapiens 8.9 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621053&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544065 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCCCC3)ncc2N(C)C1=O InChI=1S/C30H41N7O3/c1-4-23-29(39)34(2)25-18-31-30(33-28(25)37(23)21-10-6-7-11-21)32-22-17-24-20(16-26(22)40-3)12-15-36(24)27(38)19-35-13-8-5-9-14-35/h16-18,21,23H,4-15,19H2,1-3H3,(H,31,32,33)/t23-/m1/s1 RGLDTELFIMHCAY-HSZRJFAPSA-N 50621054 CHEMBL5395241 Serine/threonine-protein kinase PLK1 Homo sapiens 4.0 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621054&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544066 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCC[C@H]3CO)ncc2N(C)C1=O InChI=1S/C30H41N7O4/c1-4-23-29(40)34(2)25-16-31-30(33-28(25)37(23)20-8-5-6-9-20)32-22-15-24-19(14-26(22)41-3)11-13-36(24)27(39)17-35-12-7-10-21(35)18-38/h14-16,20-21,23,38H,4-13,17-18H2,1-3H3,(H,31,32,33)/t21-,23+/m0/s1 LQPBRMWKFJKVSW-JTHBVZDNSA-N 50621055 CHEMBL5402431 Serine/threonine-protein kinase PLK1 Homo sapiens 3.3 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621055&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544067 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCC(O)CC3)ncc2N(C)C1=O InChI=1S/C30H41N7O4/c1-4-23-29(40)34(2)25-17-31-30(33-28(25)37(23)20-7-5-6-8-20)32-22-16-24-19(15-26(22)41-3)9-14-36(24)27(39)18-35-12-10-21(38)11-13-35/h15-17,20-21,23,38H,4-14,18H2,1-3H3,(H,31,32,33)/t23-/m1/s1 BLOOVKYIUMFKLC-HSZRJFAPSA-N 50621056 CHEMBL5408013 Serine/threonine-protein kinase PLK1 Homo sapiens 5.2 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621056&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544068 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCC(C)CC3)ncc2N(C)C1=O InChI=1S/C31H43N7O3/c1-5-24-30(40)35(3)26-18-32-31(34-29(26)38(24)22-8-6-7-9-22)33-23-17-25-21(16-27(23)41-4)12-15-37(25)28(39)19-36-13-10-20(2)11-14-36/h16-18,20,22,24H,5-15,19H2,1-4H3,(H,32,33,34)/t24-/m1/s1 BGPJKNPJQSLQTE-XMMPIXPASA-N 50621057 CHEMBL5418320 Serine/threonine-protein kinase PLK1 Homo sapiens 8.6 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621057&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544069 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCCC(C)C3)ncc2N(C)C1=O InChI=1S/C31H43N7O3/c1-5-24-30(40)35(3)26-17-32-31(34-29(26)38(24)22-10-6-7-11-22)33-23-16-25-21(15-27(23)41-4)12-14-37(25)28(39)19-36-13-8-9-20(2)18-36/h15-17,20,22,24H,5-14,18-19H2,1-4H3,(H,32,33,34)/t20?,24-/m1/s1 MIRVHAMRCDOLJQ-PIFIWZBESA-N 50621058 CHEMBL5402704 Serine/threonine-protein kinase PLK1 Homo sapiens 6.5 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621058&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544070 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCOCC3)ncc2N(C)C1=O InChI=1S/C29H39N7O4/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-7-5-6-8-20)31-21-16-23-19(15-25(21)39-3)9-10-35(23)26(37)18-34-11-13-40-14-12-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 WDAZXJBJHQKRNA-JOCHJYFZSA-N 50621059 CHEMBL5428017 Serine/threonine-protein kinase PLK1 Homo sapiens 2.3 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621059&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544071 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCSCC3)ncc2N(C)C1=O InChI=1S/C29H39N7O3S/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-7-5-6-8-20)31-21-16-23-19(15-25(21)39-3)9-10-35(23)26(37)18-34-11-13-40-14-12-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 VEUMTIQGKUVYJM-JOCHJYFZSA-N 50621060 CHEMBL5440739 Serine/threonine-protein kinase PLK1 Homo sapiens 1.6 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621060&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544072 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C30H42N8O3/c1-5-23-29(40)35(3)25-18-31-30(33-28(25)38(23)21-8-6-7-9-21)32-22-17-24-20(16-26(22)41-4)10-11-37(24)27(39)19-36-14-12-34(2)13-15-36/h16-18,21,23H,5-15,19H2,1-4H3,(H,31,32,33)/t23-/m1/s1 HYBJJIWZOKSTHG-HSZRJFAPSA-N 50621061 CHEMBL5415794 Serine/threonine-protein kinase PLK1 Homo sapiens 3.6 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621061&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544073 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC)CC3)ncc2N(C)C1=O InChI=1S/C31H44N8O3/c1-5-24-30(41)35(3)26-19-32-31(34-29(26)39(24)22-9-7-8-10-22)33-23-18-25-21(17-27(23)42-4)11-12-38(25)28(40)20-37-15-13-36(6-2)14-16-37/h17-19,22,24H,5-16,20H2,1-4H3,(H,32,33,34)/t24-/m1/s1 NXQOLMGRMCDKAS-XMMPIXPASA-N 50621062 CHEMBL5422930 Serine/threonine-protein kinase PLK1 Homo sapiens 8.6 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621062&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544074 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)C(C)C)ncc2N(C)C1=O InChI=1S/C32H46N8O3/c1-6-25-31(42)36(4)27-19-33-32(35-30(27)40(25)23-9-7-8-10-23)34-24-18-26-22(17-28(24)43-5)11-12-39(26)29(41)20-37-13-15-38(16-14-37)21(2)3/h17-19,21,23,25H,6-16,20H2,1-5H3,(H,33,34,35)/t25-/m1/s1 NHKAFPBCWTVDHF-RUZDIDTESA-N 50621063 CHEMBL5437467 Serine/threonine-protein kinase PLK1 Homo sapiens 5.3 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621063&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544075 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3C[C@H](C)N[C@H](C)C3)ncc2N(C)C1=O InChI=1S/C31H44N8O3/c1-6-24-30(41)36(4)26-15-32-31(35-29(26)39(24)22-9-7-8-10-22)34-23-14-25-21(13-27(23)42-5)11-12-38(25)28(40)18-37-16-19(2)33-20(3)17-37/h13-15,19-20,22,24,33H,6-12,16-18H2,1-5H3,(H,32,34,35)/t19-,20+,24-/m1/s1 UBHSIXJDGMNJFU-JXALWOEJSA-N 50621064 CHEMBL5412529 Serine/threonine-protein kinase PLK1 Homo sapiens 7.2 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621064&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544076 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)C3CCCC3)ncc2N(C)C1=O InChI=1S/C34H48N8O3/c1-4-27-33(44)38(2)29-21-35-34(37-32(29)42(27)25-11-7-8-12-25)36-26-20-28-23(19-30(26)45-3)13-14-41(28)31(43)22-39-15-17-40(18-16-39)24-9-5-6-10-24/h19-21,24-25,27H,4-18,22H2,1-3H3,(H,35,36,37)/t27-/m1/s1 GYZIZQNRYSAHLB-HHHXNRCGSA-N 50621065 CHEMBL5410310 Serine/threonine-protein kinase PLK1 Homo sapiens 5.2 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621065&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544077 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)C(C)=O)ncc2N(C)C1=O InChI=1S/C31H42N8O4/c1-5-24-30(42)35(3)26-18-32-31(34-29(26)39(24)22-8-6-7-9-22)33-23-17-25-21(16-27(23)43-4)10-11-38(25)28(41)19-36-12-14-37(15-13-36)20(2)40/h16-18,22,24H,5-15,19H2,1-4H3,(H,32,33,34)/t24-/m1/s1 MQTVRTKADRPRCF-XMMPIXPASA-N 50621066 CHEMBL5402922 Serine/threonine-protein kinase PLK1 Homo sapiens 3.0 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621066&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544078 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CCO)CC3)ncc2N(C)C1=O InChI=1S/C31H44N8O4/c1-4-24-30(42)35(2)26-19-32-31(34-29(26)39(24)22-7-5-6-8-22)33-23-18-25-21(17-27(23)43-3)9-10-38(25)28(41)20-37-13-11-36(12-14-37)15-16-40/h17-19,22,24,40H,4-16,20H2,1-3H3,(H,32,33,34)/t24-/m1/s1 DFHYGDMTHXOWJZ-XMMPIXPASA-N 50621067 CHEMBL5417441 Serine/threonine-protein kinase PLK1 Homo sapiens 8.8 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621067&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544079 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)S(C)(=O)=O)ncc2N(C)C1=O InChI=1S/C30H42N8O5S/c1-5-23-29(40)34(2)25-18-31-30(33-28(25)38(23)21-8-6-7-9-21)32-22-17-24-20(16-26(22)43-3)10-11-37(24)27(39)19-35-12-14-36(15-13-35)44(4,41)42/h16-18,21,23H,5-15,19H2,1-4H3,(H,31,32,33)/t23-/m1/s1 QDYSUCFDCGSSEQ-HSZRJFAPSA-N 50621068 CHEMBL5417454 Serine/threonine-protein kinase PLK1 Homo sapiens 4.1 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621068&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544080 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN(CC)CC)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H41N7O3/c1-6-22-28(38)33(4)24-17-30-29(32-27(24)36(22)20-11-9-10-12-20)31-21-15-19-13-14-35(23(19)16-25(21)39-5)26(37)18-34(7-2)8-3/h15-17,20,22H,6-14,18H2,1-5H3,(H,30,31,32)/t22-/m1/s1 COKMLSIYYSUCIR-JOCHJYFZSA-N 50621069 CHEMBL5409700 Serine/threonine-protein kinase PLK1 Homo sapiens 0.900000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621069&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544081 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H39N7O3/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-9-5-6-10-20)31-21-15-19-11-14-35(23(19)16-25(21)39-3)26(37)18-34-12-7-8-13-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 HHZMJLZHVLBSKE-JOCHJYFZSA-N 50621070 CHEMBL5403358 Serine/threonine-protein kinase PLK1 Homo sapiens 0.500000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621070&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544082 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCC[C@H]5CO)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H41N7O4/c1-4-23-29(40)34(2)25-16-31-30(33-28(25)37(23)20-8-5-6-9-20)32-22-14-19-11-13-36(24(19)15-26(22)41-3)27(39)17-35-12-7-10-21(35)18-38/h14-16,20-21,23,38H,4-13,17-18H2,1-3H3,(H,31,32,33)/t21-,23+/m0/s1 FBULVHVJQISAMG-JTHBVZDNSA-N 50621071 CHEMBL5427957 Serine/threonine-protein kinase PLK1 Homo sapiens 0.400000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621071&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544083 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCCCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H41N7O3/c1-4-23-29(39)34(2)25-18-31-30(33-28(25)37(23)21-10-6-7-11-21)32-22-16-20-12-15-36(24(20)17-26(22)40-3)27(38)19-35-13-8-5-9-14-35/h16-18,21,23H,4-15,19H2,1-3H3,(H,31,32,33)/t23-/m1/s1 YCNMRNSZEJLPCH-HSZRJFAPSA-N 50621072 CHEMBL5426964 Serine/threonine-protein kinase PLK1 Homo sapiens 0.300000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621072&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544084 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCC(O)CC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H41N7O4/c1-4-23-29(40)34(2)25-17-31-30(33-28(25)37(23)20-7-5-6-8-20)32-22-15-19-9-14-36(24(19)16-26(22)41-3)27(39)18-35-12-10-21(38)11-13-35/h15-17,20-21,23,38H,4-14,18H2,1-3H3,(H,31,32,33)/t23-/m1/s1 FRIZQAUPYMDOBS-HSZRJFAPSA-N 50621073 CHEMBL5428087 Serine/threonine-protein kinase PLK1 Homo sapiens 0.700000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621073&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544085 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCOCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H39N7O4/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-7-5-6-8-20)31-21-15-19-9-10-35(23(19)16-25(21)39-3)26(37)18-34-11-13-40-14-12-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 BQOVFHDJHUGBES-JOCHJYFZSA-N 50621074 CHEMBL5418129 Serine/threonine-protein kinase PLK1 Homo sapiens 0.500000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621074&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544086 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCSCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H39N7O3S/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-7-5-6-8-20)31-21-15-19-9-10-35(23(19)16-25(21)39-3)26(37)18-34-11-13-40-14-12-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 SVUXDKXAQKMLIM-JOCHJYFZSA-N 50621075 CHEMBL5398977 Serine/threonine-protein kinase PLK1 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621075&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544087 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCS(=O)(=O)CC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H39N7O5S/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-7-5-6-8-20)31-21-15-19-9-10-35(23(19)16-25(21)41-3)26(37)18-34-11-13-42(39,40)14-12-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 BEILSCWVGFIDJL-JOCHJYFZSA-N 50621076 CHEMBL5395480 Serine/threonine-protein kinase PLK1 Homo sapiens 0.500000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621076&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544088 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCN(C)CC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H42N8O3/c1-5-23-29(40)35(3)25-18-31-30(33-28(25)38(23)21-8-6-7-9-21)32-22-16-20-10-11-37(24(20)17-26(22)41-4)27(39)19-36-14-12-34(2)13-15-36/h16-18,21,23H,5-15,19H2,1-4H3,(H,31,32,33)/t23-/m1/s1 RUHXXMHOKIHJKY-HSZRJFAPSA-N 50621077 CHEMBL5419367 Serine/threonine-protein kinase PLK1 Homo sapiens 0.300000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621077&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544089 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5C[C@H](C)N[C@H](C)C5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C31H44N8O3/c1-6-24-30(41)36(4)26-15-32-31(35-29(26)39(24)22-9-7-8-10-22)34-23-13-21-11-12-38(25(21)14-27(23)42-5)28(40)18-37-16-19(2)33-20(3)17-37/h13-15,19-20,22,24,33H,6-12,16-18H2,1-5H3,(H,32,34,35)/t19-,20+,24-/m1/s1 LBAXGISUFHVKPW-JXALWOEJSA-N 50621046 CHEMBL5429440 Serine/threonine-protein kinase PLK1 Homo sapiens 0.300000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621046&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544090 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCN(CC5)C(C)=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C31H42N8O4/c1-5-24-30(42)35(3)26-18-32-31(34-29(26)39(24)22-8-6-7-9-22)33-23-16-21-10-11-38(25(21)17-27(23)43-4)28(41)19-36-12-14-37(15-13-36)20(2)40/h16-18,22,24H,5-15,19H2,1-4H3,(H,32,33,34)/t24-/m1/s1 PIFGWPSMJFVPFI-XMMPIXPASA-N 50621078 CHEMBL5438409 Serine/threonine-protein kinase PLK1 Homo sapiens 0.720000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621078&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544091 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCN(CCO)CC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C31H44N8O4/c1-4-24-30(42)35(2)26-19-32-31(34-29(26)39(24)22-7-5-6-8-22)33-23-17-21-9-10-38(25(21)18-27(23)43-3)28(41)20-37-13-11-36(12-14-37)15-16-40/h17-19,22,24,40H,4-16,20H2,1-3H3,(H,32,33,34)/t24-/m1/s1 GVQYCXUWKTZCKO-XMMPIXPASA-N 50621079 CHEMBL5394764 Serine/threonine-protein kinase PLK1 Homo sapiens 0.600000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621079&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544092 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCN(CC5)S(C)(=O)=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H42N8O5S/c1-5-23-29(40)34(2)25-18-31-30(33-28(25)38(23)21-8-6-7-9-21)32-22-16-20-10-11-37(24(20)17-26(22)43-3)27(39)19-35-12-14-36(15-13-35)44(4,41)42/h16-18,21,23H,5-15,19H2,1-4H3,(H,31,32,33)/t23-/m1/s1 QKXLHLCDBNXSBT-HSZRJFAPSA-N 50621047 CHEMBL5401381 Serine/threonine-protein kinase PLK1 Homo sapiens 0.500000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621047&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544093 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CNC5CC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C28H37N7O3/c1-4-21-27(37)33(2)23-15-30-28(32-26(23)35(21)19-7-5-6-8-19)31-20-13-17-11-12-34(22(17)14-24(20)38-3)25(36)16-29-18-9-10-18/h13-15,18-19,21,29H,4-12,16H2,1-3H3,(H,30,31,32)/t21-/m1/s1 OSBPICGFSLCYPI-OAQYLSRUSA-N 50621080 CHEMBL5422122 Serine/threonine-protein kinase PLK1 Homo sapiens 0.300000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621080&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544094 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CCN(C(=O)CNC5CCCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H41N7O3/c1-4-23-29(39)35(2)25-17-32-30(34-28(25)37(23)21-11-7-8-12-21)33-22-15-19-13-14-36(24(19)16-26(22)40-3)27(38)18-31-20-9-5-6-10-20/h15-17,20-21,23,31H,4-14,18H2,1-3H3,(H,32,33,34)/t23-/m1/s1 FPKFEJQELSGORT-HSZRJFAPSA-N 50621081 CHEMBL5416208 Serine/threonine-protein kinase PLK1 Homo sapiens 0.200000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621081&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544095 CC[C@H]1N(CC2CCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)C(C)=O)ncc2N(C)C1=O InChI=1S/C32H44N8O4/c1-5-25-31(43)36(3)27-18-33-32(35-30(27)40(25)19-22-8-6-7-9-22)34-24-17-26-23(16-28(24)44-4)10-11-39(26)29(42)20-37-12-14-38(15-13-37)21(2)41/h16-18,22,25H,5-15,19-20H2,1-4H3,(H,33,34,35)/t25-/m1/s1 AGPXNBSUAVZEBN-RUZDIDTESA-N 50621082 CHEMBL5405036 Serine/threonine-protein kinase PLK1 Homo sapiens 1.6 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621082&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544096 CC[C@H]1N(Cc2cc(C)cs2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)C(C)=O)ncc2N(C)C1=O InChI=1S/C32H40N8O4S/c1-6-25-31(43)36(4)27-16-33-32(35-30(27)40(25)17-23-13-20(2)19-45-23)34-24-15-26-22(14-28(24)44-5)7-8-39(26)29(42)18-37-9-11-38(12-10-37)21(3)41/h13-16,19,25H,6-12,17-18H2,1-5H3,(H,33,34,35)/t25-/m1/s1 MCDYUDVJKXYKNA-RUZDIDTESA-N 50621083 CHEMBL5426693 Serine/threonine-protein kinase PLK1 Homo sapiens 10 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621083&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544097 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)C(C)=O)ncc2N(C)C1=O InChI=1S/C33H46N8O4/c1-5-26-32(44)37(3)28-19-34-33(36-31(28)41(26)20-23-9-7-6-8-10-23)35-25-18-27-24(17-29(25)45-4)11-12-40(27)30(43)21-38-13-15-39(16-14-38)22(2)42/h17-19,23,26H,5-16,20-21H2,1-4H3,(H,34,35,36)/t26-/m1/s1 VBYSCQVUJACHHJ-AREMUKBSSA-N 50621084 CHEMBL5422245 Serine/threonine-protein kinase PLK1 Homo sapiens 70 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621084&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544098 CC[C@H]1N(Cc2cccs2)c2nc(Nc3cc4N(CCc4cc3OC)C(=O)CN3CCN(CC3)C(C)=O)ncc2N(C)C1=O InChI=1S/C31H38N8O4S/c1-5-24-30(42)35(3)26-17-32-31(34-29(26)39(24)18-22-7-6-14-44-22)33-23-16-25-21(15-27(23)43-4)8-9-38(25)28(41)19-36-10-12-37(13-11-36)20(2)40/h6-7,14-17,24H,5,8-13,18-19H2,1-4H3,(H,32,33,34)/t24-/m1/s1 FHOHNZUUIVYNKQ-XMMPIXPASA-N 50621085 CHEMBL5430428 Serine/threonine-protein kinase PLK1 Homo sapiens 4.1 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621085&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544099 CC[C@H]1N(C2CCCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCN(CC5)C(C)=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C32H44N8O4/c1-5-25-31(43)36(3)27-19-33-32(35-30(27)40(25)23-9-7-6-8-10-23)34-24-17-22-11-12-39(26(22)18-28(24)44-4)29(42)20-37-13-15-38(16-14-37)21(2)41/h17-19,23,25H,5-16,20H2,1-4H3,(H,33,34,35)/t25-/m1/s1 YXXGXTGIMJQZFA-RUZDIDTESA-N 50621086 CHEMBL5403473 Serine/threonine-protein kinase PLK1 Homo sapiens 0.420000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621086&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544100 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCN(CC5)C(C)=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C33H46N8O4/c1-5-26-32(44)37(3)28-19-34-33(36-31(28)41(26)20-23-9-7-6-8-10-23)35-25-17-24-11-12-40(27(24)18-29(25)45-4)30(43)21-38-13-15-39(16-14-38)22(2)42/h17-19,23,26H,5-16,20-21H2,1-4H3,(H,34,35,36)/t26-/m1/s1 YPKNIQOOBNDEBF-AREMUKBSSA-N 50621087 CHEMBL5406467 Serine/threonine-protein kinase PLK1 Homo sapiens 2.0 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621087&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544101 CC[C@H]1N(Cc2cccs2)c2nc(Nc3cc4CCN(C(=O)CN5CCN(CC5)C(C)=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C31H38N8O4S/c1-5-24-30(42)35(3)26-17-32-31(34-29(26)39(24)18-22-7-6-14-44-22)33-23-15-21-8-9-38(25(21)16-27(23)43-4)28(41)19-36-10-12-37(13-11-36)20(2)40/h6-7,14-17,24H,5,8-13,18-19H2,1-4H3,(H,32,33,34)/t24-/m1/s1 HYADALKUILXFKH-XMMPIXPASA-N 50621088 CHEMBL5437723 Serine/threonine-protein kinase PLK1 Homo sapiens 3.1 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621088&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544102 CC[C@H]1N(CC2CCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCOCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H41N7O4/c1-4-23-29(39)34(2)25-17-31-30(33-28(25)37(23)18-20-7-5-6-8-20)32-22-15-21-9-10-36(24(21)16-26(22)40-3)27(38)19-35-11-13-41-14-12-35/h15-17,20,23H,4-14,18-19H2,1-3H3,(H,31,32,33)/t23-/m1/s1 ACASXOCRQAMKNU-HSZRJFAPSA-N 50621089 CHEMBL5408776 Serine/threonine-protein kinase PLK1 Homo sapiens 0.940000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621089&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544103 CC[C@H]1N(C2CCCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCOCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C30H41N7O4/c1-4-23-29(39)34(2)25-18-31-30(33-28(25)37(23)21-8-6-5-7-9-21)32-22-16-20-10-11-36(24(20)17-26(22)40-3)27(38)19-35-12-14-41-15-13-35/h16-18,21,23H,4-15,19H2,1-3H3,(H,31,32,33)/t23-/m1/s1 JSZIMXVEMYQOJI-HSZRJFAPSA-N 50621090 CHEMBL5417495 Serine/threonine-protein kinase PLK1 Homo sapiens 0.170000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621090&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544104 CC[C@H]1N(CC2CCCCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCOCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C31H43N7O4/c1-4-24-30(40)35(2)26-18-32-31(34-29(26)38(24)19-21-8-6-5-7-9-21)33-23-16-22-10-11-37(25(22)17-27(23)41-3)28(39)20-36-12-14-42-15-13-36/h16-18,21,24H,4-15,19-20H2,1-3H3,(H,32,33,34)/t24-/m1/s1 GGVHAVDTMKMLJT-XMMPIXPASA-N 50621091 CHEMBL5415796 Serine/threonine-protein kinase PLK1 Homo sapiens 2.1 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621091&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544105 CC[C@H]1N(Cc2cccs2)c2nc(Nc3cc4CCN(C(=O)CN5CCOCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H35N7O4S/c1-4-22-28(38)33(2)24-16-30-29(32-27(24)36(22)17-20-6-5-13-41-20)31-21-14-19-7-8-35(23(19)15-25(21)39-3)26(37)18-34-9-11-40-12-10-34/h5-6,13-16,22H,4,7-12,17-18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 KZQUEDZXRXCNKM-JOCHJYFZSA-N 50621092 CHEMBL5409453 Serine/threonine-protein kinase PLK1 Homo sapiens 1.3 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621092&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544106 CC[C@H]1N(C2CCOCC2)c2nc(Nc3cc4CCN(C(=O)CN5CCOCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H39N7O5/c1-4-22-28(38)33(2)24-17-30-29(32-27(24)36(22)20-6-11-40-12-7-20)31-21-15-19-5-8-35(23(19)16-25(21)39-3)26(37)18-34-9-13-41-14-10-34/h15-17,20,22H,4-14,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 NHRDZMBJEDCSLY-JOCHJYFZSA-N 50621093 CHEMBL5421723 Serine/threonine-protein kinase PLK1 Homo sapiens 1.3 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621093&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544107 CC[C@H]1N(Cc2ccccc2)c2nc(Nc3cc4CCN(C(=O)CN5CCOCC5)c4cc3OC)ncc2N(C)C1=O InChI=1S/C31H37N7O4/c1-4-24-30(40)35(2)26-18-32-31(34-29(26)38(24)19-21-8-6-5-7-9-21)33-23-16-22-10-11-37(25(22)17-27(23)41-3)28(39)20-36-12-14-42-15-13-36/h5-9,16-18,24H,4,10-15,19-20H2,1-3H3,(H,32,33,34)/t24-/m1/s1 HJVLRYLCWZPLEP-XMMPIXPASA-N 50621094 CHEMBL5400502 Serine/threonine-protein kinase PLK1 Homo sapiens 11 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621094&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544160 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)S(=O)(=O)CC(=O)N3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O5S/c1-5-22-27(37)33(3)23-17-29-28(31-26(23)35(22)19-8-6-7-9-19)30-21-11-10-20(16-24(21)40-4)41(38,39)18-25(36)34-14-12-32(2)13-15-34/h10-11,16-17,19,22H,5-9,12-15,18H2,1-4H3,(H,29,30,31)/t22-/m1/s1 IBHXQUPAKHOLCH-JOCHJYFZSA-N 50621095 CHEMBL5413543 Serine/threonine-protein kinase PLK1 Homo sapiens 6.3 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621095&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544163 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544057 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CN(C5CCN(C)CC5)C(=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C29H39N7O3/c1-5-23-28(38)34(3)24-16-30-29(32-26(24)36(23)20-8-6-7-9-20)31-22-14-18-17-35(19-10-12-33(2)13-11-19)27(37)21(18)15-25(22)39-4/h14-16,19-20,23H,5-13,17H2,1-4H3,(H,30,31,32)/t23-/m1/s1 DQDVRWIYUXKYQR-HSZRJFAPSA-N 50621048 CHEMBL5421238 Serine/threonine-protein kinase PLK1 Homo sapiens 0.520000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621048&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544058 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CN(C(C)C)C(=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C26H34N6O3/c1-6-20-25(34)30(4)21-13-27-26(29-23(21)32(20)17-9-7-8-10-17)28-19-11-16-14-31(15(2)3)24(33)18(16)12-22(19)35-5/h11-13,15,17,20H,6-10,14H2,1-5H3,(H,27,28,29)/t20-/m1/s1 INSOERIUGCDMID-HXUWFJFHSA-N 50621049 CHEMBL5410968 Serine/threonine-protein kinase PLK1 Homo sapiens 0.430000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621049&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544059 CC[C@H]1N(C2CCCC2)c2nc(Nc3cc4CN(C5CCCC5)C(=O)c4cc3OC)ncc2N(C)C1=O InChI=1S/C28H36N6O3/c1-4-22-27(36)32(2)23-15-29-28(31-25(23)34(22)19-11-7-8-12-19)30-21-13-17-16-33(18-9-5-6-10-18)26(35)20(17)14-24(21)37-3/h13-15,18-19,22H,4-12,16H2,1-3H3,(H,29,30,31)/t22-/m1/s1 BECCYBZVBSCVDH-JOCHJYFZSA-N 50621050 CHEMBL5412127 Serine/threonine-protein kinase PLK1 Homo sapiens 0.510000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621050&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544060 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc4C(=O)N(Cc4c3)C3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H37N7O2/c1-4-23-27(37)33(3)24-16-29-28(31-25(24)35(23)21-7-5-6-8-21)30-19-9-10-22-18(15-19)17-34(26(22)36)20-11-13-32(2)14-12-20/h9-10,15-16,20-21,23H,4-8,11-14,17H2,1-3H3,(H,29,30,31)/t23-/m1/s1 DWDZLNLDCMCRMS-HSZRJFAPSA-N 50621051 CHEMBL5437669 Serine/threonine-protein kinase PLK1 Homo sapiens 0.650000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621051&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544061 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.900000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51544062 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 0.820000 ChEMBL 10.1016/j.bmc.2024.117609 10.7270/Q26W9GGX 38364599 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51576148 OC(=O)c1ccc2N[C@H]([C@H]3CC=C[C@H]3c2c1)c1ccccn1 InChI=1S/C18H16N2O2/c21-18(22)11-7-8-15-14(10-11)12-4-3-5-13(12)17(20-15)16-6-1-2-9-19-16/h1-4,6-10,12-13,17,20H,5H2,(H,21,22)/t12-,13+,17-/m1/s1 QTKRLZDSHXZXNP-IIYDPXPESA-N 40037 (3aS,4R,9bR)-4-(2-pyridinyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid::(3aS,4R,9bR)-4-(2-pyridyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid::(3aS,4R,9bR)-4-pyridin-2-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid::4-Pyridin-2-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid::MLS000085196::SMR000019736::cid_1203912 Serine/threonine-protein kinase PLK1 Homo sapiens 17000 ChEMBL 10.1021/acs.jmedchem.3c01277 10.7270/Q2JM2G44 37874947 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40037&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1203912 252620867 ZINC00972005 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51574384 Oc1ccc2[nH]c3c4[nH]c5ccccc5c4c4CNC(=O)c4c3c2c1 InChI=1S/C20H13N3O2/c24-9-5-6-14-11(7-9)16-17-12(8-21-20(17)25)15-10-3-1-2-4-13(10)22-18(15)19(16)23-14/h1-7,22-24H,8H2,(H,21,25) GXZFDXZCJALHRF-UHFFFAOYSA-N 50465331 CHEMBL4294912 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2023.115181 10.7270/Q2W95FP1 36764122 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50465331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50465331&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 139589939 433932596 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51570517 COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1NC(=O)CCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O InChI=1S/C28H37N5O8/c1-38-21-10-9-17(7-8-18-15-22(39-2)26(41-4)23(16-18)40-3)14-20(21)33-25(35)12-11-24(34)32-19(27(36)37)6-5-13-31-28(29)30/h7-10,14-16,19H,5-6,11-13H2,1-4H3,(H,32,34)(H,33,35)(H,36,37)(H4,29,30,31)/b8-7-/t19-/m0/s1 BNWIVWQCCFRSQN-FQQSSWHASA-N 50631617 CHEMBL5440517 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.3c01572 10.7270/Q2XS60VD 38093696 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631617&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556819 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.830000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556820 [Na+].COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1 InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+; VLQLUZFVFXYXQE-USRGLUTNSA-M 50626572 Estybon::ON 01910 SODIUM::ON 01910.NA::ON-01910::ON-01910 SODIUM::ON-01910.NA::ON01910 SODIUM::On-01910.na::RIGOSERTIB SODIUM::Rigosertib sodium::SYB C-1101 Serine/threonine-protein kinase PLK1 Homo sapiens 9.0 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626572&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556821 CC[C@H]1N(C(C)C)c2nc(Nc3ccc(cc3OC)C(=O)N[C@H]3CC[C@@H](CC3)N3CCN(CC4CC4)CC3)ncc2N(C)C1=O InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25-,26-,28-/m1/s1 SXNJFOWDRLKDSF-STROYTFGSA-N 50402023 BI 6727::VOLASERTIB Serine/threonine-protein kinase PLK1 Homo sapiens 0.870000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50402023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50402023&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search IBI 7LEJ,7N7N,7LAK,3FC2,5VBR,5V67 10461508 163351047 ZINC39716290 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556822 CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1 InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31) QHLVBNKYJGBCQJ-UHFFFAOYSA-N 50343559 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE::1-(2-hydroxyethyl)-8-(5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide::CHEMBL1738758 Serine/threonine-protein kinase PLK1 Homo sapiens 2.0 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343559&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 937 2YAC 49792852 131346495 CHEMBL1738758 ZINC43196885 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556823 COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1 InChI=1S/C27H34F3N7O3/c1-35-10-8-16(9-11-35)32-24(38)18-12-22(40-3)20(13-19(18)28)33-26-31-14-21-23(34-26)37(17-6-4-5-7-17)15-27(29,30)25(39)36(21)2/h12-14,16-17H,4-11,15H2,1-3H3,(H,32,38)(H,31,33,34) GWRSATNRNFYMDI-UHFFFAOYSA-N 50435727 CHEMBL2392545 Serine/threonine-protein kinase PLK1 Homo sapiens 0.800000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435727&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1J4 4J53 53357478 175448044 CHEMBL2392545 ZINC43203898 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556824 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CNC4CCN(C)CC4)o3)ncc2N(C)C1=O InChI=1S/C30H41N9O3/c1-5-23-29(40)38(3)24-17-32-30(34-27(24)39(23)21-8-6-7-9-21)33-22-11-10-19(16-25(22)41-4)28-36-35-26(42-28)18-31-20-12-14-37(2)15-13-20/h10-11,16-17,20-21,23,31H,5-9,12-15,18H2,1-4H3,(H,32,33,34)/t23-/m1/s1 NXDKPIQNQHYTBJ-HSZRJFAPSA-N 50626573 CHEMBL5421113 Serine/threonine-protein kinase PLK1 Homo sapiens 0.300000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626573&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556825 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CNC4CC4)o3)ncc2N(C)C1=O InChI=1S/C27H34N8O3/c1-4-20-26(36)34(2)21-14-29-27(31-24(21)35(20)18-7-5-6-8-18)30-19-12-9-16(13-22(19)37-3)25-33-32-23(38-25)15-28-17-10-11-17/h9,12-14,17-18,20,28H,4-8,10-11,15H2,1-3H3,(H,29,30,31)/t20-/m1/s1 YAHKLZWRTFAXGN-HXUWFJFHSA-N 50626574 CHEMBL5430202 Serine/threonine-protein kinase PLK1 Homo sapiens 0.530000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626574&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556826 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CNC4CCC4)o3)ncc2N(C)C1=O InChI=1S/C28H36N8O3/c1-4-21-27(37)35(2)22-15-30-28(32-25(22)36(21)19-10-5-6-11-19)31-20-13-12-17(14-23(20)38-3)26-34-33-24(39-26)16-29-18-8-7-9-18/h12-15,18-19,21,29H,4-11,16H2,1-3H3,(H,30,31,32)/t21-/m1/s1 PTTXNZJXZIHFHY-OAQYLSRUSA-N 50626575 CHEMBL5419732 Serine/threonine-protein kinase PLK1 Homo sapiens 0.190000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626575&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556827 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CNC4CCCC4)o3)ncc2N(C)C1=O InChI=1S/C29H38N8O3/c1-4-22-28(38)36(2)23-16-31-29(33-26(23)37(22)20-11-7-8-12-20)32-21-14-13-18(15-24(21)39-3)27-35-34-25(40-27)17-30-19-9-5-6-10-19/h13-16,19-20,22,30H,4-12,17H2,1-3H3,(H,31,32,33)/t22-/m1/s1 QXNQNDZURHUASP-JOCHJYFZSA-N 50626576 CHEMBL5437785 Serine/threonine-protein kinase PLK1 Homo sapiens 0.400000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626576&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556828 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CNCC4CC4)o3)ncc2N(C)C1=O InChI=1S/C28H36N8O3/c1-4-21-27(37)35(2)22-15-30-28(32-25(22)36(21)19-7-5-6-8-19)31-20-12-11-18(13-23(20)38-3)26-34-33-24(39-26)16-29-14-17-9-10-17/h11-13,15,17,19,21,29H,4-10,14,16H2,1-3H3,(H,30,31,32)/t21-/m1/s1 SMGYMGPXTAUBHS-OAQYLSRUSA-N 50626577 CHEMBL5396078 Serine/threonine-protein kinase PLK1 Homo sapiens 0.390000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626577&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556829 CCC(CC)NCc1nnc(o1)-c1ccc(Nc2ncc3N(C)C(=O)[C@@H](CC)N(C4CCCC4)c3n2)c(OC)c1 InChI=1S/C29H40N8O3/c1-6-19(7-2)30-17-25-34-35-27(40-25)18-13-14-21(24(15-18)39-5)32-29-31-16-23-26(33-29)37(20-11-9-10-12-20)22(8-3)28(38)36(23)4/h13-16,19-20,22,30H,6-12,17H2,1-5H3,(H,31,32,33)/t22-/m1/s1 UEBLZSXSCDJPDA-JOCHJYFZSA-N 50626578 CHEMBL5403446 Serine/threonine-protein kinase PLK1 Homo sapiens 0.690000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626578&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556830 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN(C)C)o3)ncc2N(C)C1=O InChI=1S/C26H34N8O3/c1-6-19-25(35)33(4)20-14-27-26(29-23(20)34(19)17-9-7-8-10-17)28-18-12-11-16(13-21(18)36-5)24-31-30-22(37-24)15-32(2)3/h11-14,17,19H,6-10,15H2,1-5H3,(H,27,28,29)/t19-/m1/s1 VIWFGOHUMHLUTJ-LJQANCHMSA-N 50626579 CHEMBL5438707 Serine/threonine-protein kinase PLK1 Homo sapiens 0.230000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626579&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556831 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN(C)CCN(C)C)o3)ncc2N(C)C1=O InChI=1S/C29H41N9O3/c1-7-22-28(39)37(5)23-17-30-29(32-26(23)38(22)20-10-8-9-11-20)31-21-13-12-19(16-24(21)40-6)27-34-33-25(41-27)18-36(4)15-14-35(2)3/h12-13,16-17,20,22H,7-11,14-15,18H2,1-6H3,(H,30,31,32)/t22-/m1/s1 DEGJXEBDPRUGAW-JOCHJYFZSA-N 50626580 CHEMBL5439937 Serine/threonine-protein kinase PLK1 Homo sapiens 0.640000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626580&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556832 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCCC4)o3)ncc2N(C)C1=O InChI=1S/C28H36N8O3/c1-4-21-27(37)34(2)22-16-29-28(31-25(22)36(21)19-9-5-6-10-19)30-20-12-11-18(15-23(20)38-3)26-33-32-24(39-26)17-35-13-7-8-14-35/h11-12,15-16,19,21H,4-10,13-14,17H2,1-3H3,(H,29,30,31)/t21-/m1/s1 ABPDFJOBKRDVFF-OAQYLSRUSA-N 50626581 CHEMBL5434561 Serine/threonine-protein kinase PLK1 Homo sapiens 0.600000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626581&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556833 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCCCC4)o3)ncc2N(C)C1=O InChI=1S/C29H38N8O3/c1-4-22-28(38)35(2)23-17-30-29(32-26(23)37(22)20-10-6-7-11-20)31-21-13-12-19(16-24(21)39-3)27-34-33-25(40-27)18-36-14-8-5-9-15-36/h12-13,16-17,20,22H,4-11,14-15,18H2,1-3H3,(H,30,31,32)/t22-/m1/s1 RYSXBYPXSXGPSK-JOCHJYFZSA-N 50626582 CHEMBL5395023 Serine/threonine-protein kinase PLK1 Homo sapiens 0.620000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626582&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556834 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCC[C@H]4CO)o3)ncc2N(C)C1=O InChI=1S/C29H38N8O4/c1-4-22-28(39)35(2)23-15-30-29(32-26(23)37(22)19-8-5-6-9-19)31-21-12-11-18(14-24(21)40-3)27-34-33-25(41-27)16-36-13-7-10-20(36)17-38/h11-12,14-15,19-20,22,38H,4-10,13,16-17H2,1-3H3,(H,30,31,32)/t20-,22+/m0/s1 PDXZYNCBHFJSRH-RBBKRZOGSA-N 50626583 CHEMBL5433401 Serine/threonine-protein kinase PLK1 Homo sapiens 0.230000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626583&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556835 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCC(O)CC4)o3)ncc2N(C)C1=O InChI=1S/C29H38N8O4/c1-4-22-28(39)35(2)23-16-30-29(32-26(23)37(22)19-7-5-6-8-19)31-21-10-9-18(15-24(21)40-3)27-34-33-25(41-27)17-36-13-11-20(38)12-14-36/h9-10,15-16,19-20,22,38H,4-8,11-14,17H2,1-3H3,(H,30,31,32)/t22-/m1/s1 RGGAMSLOYJZUBD-JOCHJYFZSA-N 50626584 CHEMBL5401755 Serine/threonine-protein kinase PLK1 Homo sapiens 0.550000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626584&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556836 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCC(F)(F)CC4)o3)ncc2N(C)C1=O InChI=1S/C29H36F2N8O3/c1-4-21-27(40)37(2)22-16-32-28(34-25(22)39(21)19-7-5-6-8-19)33-20-10-9-18(15-23(20)41-3)26-36-35-24(42-26)17-38-13-11-29(30,31)12-14-38/h9-10,15-16,19,21H,4-8,11-14,17H2,1-3H3,(H,32,33,34)/t21-/m1/s1 YBDPCQOHDIWBHK-OAQYLSRUSA-N 50626585 CHEMBL5404388 Serine/threonine-protein kinase PLK1 Homo sapiens 1.1 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626585&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556837 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCOCC4)o3)ncc2N(C)C1=O InChI=1S/C28H36N8O4/c1-4-21-27(37)34(2)22-16-29-28(31-25(22)36(21)19-7-5-6-8-19)30-20-10-9-18(15-23(20)38-3)26-33-32-24(40-26)17-35-11-13-39-14-12-35/h9-10,15-16,19,21H,4-8,11-14,17H2,1-3H3,(H,29,30,31)/t21-/m1/s1 JCALTRUJZUJVNM-OAQYLSRUSA-N 50626586 CHEMBL5426743 Serine/threonine-protein kinase PLK1 Homo sapiens 0.420000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626586&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556838 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCNCC4)o3)ncc2N(C)C1=O InChI=1S/C28H37N9O3/c1-4-21-27(38)35(2)22-16-30-28(32-25(22)37(21)19-7-5-6-8-19)31-20-10-9-18(15-23(20)39-3)26-34-33-24(40-26)17-36-13-11-29-12-14-36/h9-10,15-16,19,21,29H,4-8,11-14,17H2,1-3H3,(H,30,31,32)/t21-/m1/s1 GKIDKQUOZUBMNT-OAQYLSRUSA-N 50626587 CHEMBL5429110 Serine/threonine-protein kinase PLK1 Homo sapiens 0.330000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626587&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556839 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCCNCC4)o3)ncc2N(C)C1=O InChI=1S/C29H39N9O3/c1-4-22-28(39)36(2)23-17-31-29(33-26(23)38(22)20-8-5-6-9-20)32-21-11-10-19(16-24(21)40-3)27-35-34-25(41-27)18-37-14-7-12-30-13-15-37/h10-11,16-17,20,22,30H,4-9,12-15,18H2,1-3H3,(H,31,32,33)/t22-/m1/s1 NVXUTLJJGPPKOI-JOCHJYFZSA-N 50626588 CHEMBL5402308 Serine/threonine-protein kinase PLK1 Homo sapiens 0.420000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626588&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556840 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4C[C@H](C)N[C@H](C)C4)o3)ncc2N(C)C1=O InChI=1S/C30H41N9O3/c1-6-23-29(40)37(4)24-14-31-30(34-27(24)39(23)21-9-7-8-10-21)33-22-12-11-20(13-25(22)41-5)28-36-35-26(42-28)17-38-15-18(2)32-19(3)16-38/h11-14,18-19,21,23,32H,6-10,15-17H2,1-5H3,(H,31,33,34)/t18-,19+,23-/m1/s1 KWQBQLFHHAOBPA-SELNLUPBSA-N 50626589 CHEMBL5435649 Serine/threonine-protein kinase PLK1 Homo sapiens 0.500000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626589&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556841 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCN(C)CC4)o3)ncc2N(C)C1=O InChI=1S/C29H39N9O3/c1-5-22-28(39)36(3)23-17-30-29(32-26(23)38(22)20-8-6-7-9-20)31-21-11-10-19(16-24(21)40-4)27-34-33-25(41-27)18-37-14-12-35(2)13-15-37/h10-11,16-17,20,22H,5-9,12-15,18H2,1-4H3,(H,30,31,32)/t22-/m1/s1 VDXLYKVAONWVIG-JOCHJYFZSA-N 50626590 CHEMBL5412655 Serine/threonine-protein kinase PLK1 Homo sapiens 0.790000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626590&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556842 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCN(CC)CC4)o3)ncc2N(C)C1=O InChI=1S/C30H41N9O3/c1-5-23-29(40)36(3)24-18-31-30(33-27(24)39(23)21-9-7-8-10-21)32-22-12-11-20(17-25(22)41-4)28-35-34-26(42-28)19-38-15-13-37(6-2)14-16-38/h11-12,17-18,21,23H,5-10,13-16,19H2,1-4H3,(H,31,32,33)/t23-/m1/s1 NRGJJWAGEVENNQ-HSZRJFAPSA-N 50626591 CHEMBL5400707 Serine/threonine-protein kinase PLK1 Homo sapiens 0.630000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626591&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556843 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCN(CC5CC5)CC4)o3)ncc2N(C)C1=O InChI=1S/C32H43N9O3/c1-4-25-31(42)38(2)26-18-33-32(35-29(26)41(25)23-7-5-6-8-23)34-24-12-11-22(17-27(24)43-3)30-37-36-28(44-30)20-40-15-13-39(14-16-40)19-21-9-10-21/h11-12,17-18,21,23,25H,4-10,13-16,19-20H2,1-3H3,(H,33,34,35)/t25-/m1/s1 ODLCOFODIJFOOZ-RUZDIDTESA-N 50626592 CHEMBL5416239 Serine/threonine-protein kinase PLK1 Homo sapiens 0.530000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626592&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556844 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCN(CC4)C4CCCC4)o3)ncc2N(C)C1=O InChI=1S/C33H45N9O3/c1-4-26-32(43)39(2)27-20-34-33(36-30(27)42(26)24-11-7-8-12-24)35-25-14-13-22(19-28(25)44-3)31-38-37-29(45-31)21-40-15-17-41(18-16-40)23-9-5-6-10-23/h13-14,19-20,23-24,26H,4-12,15-18,21H2,1-3H3,(H,34,35,36)/t26-/m1/s1 KLLIUCXKASRYDQ-AREMUKBSSA-N 50626593 CHEMBL5438696 Serine/threonine-protein kinase PLK1 Homo sapiens 0.340000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626593&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556845 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3nnc(CN4CCN(CCO)CC4)o3)ncc2N(C)C1=O InChI=1S/C30H41N9O4/c1-4-23-29(41)36(2)24-18-31-30(33-27(24)39(23)21-7-5-6-8-21)32-22-10-9-20(17-25(22)42-3)28-35-34-26(43-28)19-38-13-11-37(12-14-38)15-16-40/h9-10,17-18,21,23,40H,4-8,11-16,19H2,1-3H3,(H,31,32,33)/t23-/m1/s1 SAQASCKESUSWCM-HSZRJFAPSA-N 50626594 CHEMBL5394854 Serine/threonine-protein kinase PLK1 Homo sapiens 0.440000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626594&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556846 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CNC4CCN(C)CC4)n3)ncc2N(C)C1=O InChI=1S/C30H41N9O3/c1-5-23-29(40)38(3)24-17-32-30(35-28(24)39(23)21-8-6-7-9-21)33-22-11-10-19(16-25(22)41-4)27-34-26(42-36-27)18-31-20-12-14-37(2)15-13-20/h10-11,16-17,20-21,23,31H,5-9,12-15,18H2,1-4H3,(H,32,33,35)/t23-/m1/s1 FHNKQPBVTRYIOB-HSZRJFAPSA-N 50626595 CHEMBL5399905 Serine/threonine-protein kinase PLK1 Homo sapiens 0.620000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626595&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556847 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN(C)C)n3)ncc2N(C)C1=O InChI=1S/C26H34N8O3/c1-6-19-25(35)33(4)20-14-27-26(30-24(20)34(19)17-9-7-8-10-17)28-18-12-11-16(13-21(18)36-5)23-29-22(37-31-23)15-32(2)3/h11-14,17,19H,6-10,15H2,1-5H3,(H,27,28,30)/t19-/m1/s1 QGLYEWQFIDVIRT-LJQANCHMSA-N 50626596 CHEMBL5423798 Serine/threonine-protein kinase PLK1 Homo sapiens 1.0 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626596&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556848 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN(C)CCN(C)C)n3)ncc2N(C)C1=O InChI=1S/C29H41N9O3/c1-7-22-28(39)37(5)23-17-30-29(33-27(23)38(22)20-10-8-9-11-20)31-21-13-12-19(16-24(21)40-6)26-32-25(41-34-26)18-36(4)15-14-35(2)3/h12-13,16-17,20,22H,7-11,14-15,18H2,1-6H3,(H,30,31,33)/t22-/m1/s1 AVLIEIWCEPEJNY-JOCHJYFZSA-N 50626597 CHEMBL5426933 Serine/threonine-protein kinase PLK1 Homo sapiens 0.530000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626597&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556849 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCC[C@H]4CO)n3)ncc2N(C)C1=O InChI=1S/C29H38N8O4/c1-4-22-28(39)35(2)23-15-30-29(33-27(23)37(22)19-8-5-6-9-19)31-21-12-11-18(14-24(21)40-3)26-32-25(41-34-26)16-36-13-7-10-20(36)17-38/h11-12,14-15,19-20,22,38H,4-10,13,16-17H2,1-3H3,(H,30,31,33)/t20-,22+/m0/s1 JKLDGJMBOMYKLA-RBBKRZOGSA-N 50626598 CHEMBL5433215 Serine/threonine-protein kinase PLK1 Homo sapiens 0.500000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626598&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556850 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCC(O)CC4)n3)ncc2N(C)C1=O InChI=1S/C29H38N8O4/c1-4-22-28(39)35(2)23-16-30-29(33-27(23)37(22)19-7-5-6-8-19)31-21-10-9-18(15-24(21)40-3)26-32-25(41-34-26)17-36-13-11-20(38)12-14-36/h9-10,15-16,19-20,22,38H,4-8,11-14,17H2,1-3H3,(H,30,31,33)/t22-/m1/s1 OQLSZBLXFINUFG-JOCHJYFZSA-N 50626599 CHEMBL5423881 Serine/threonine-protein kinase PLK1 Homo sapiens 0.180000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626599&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556851 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCOCC4)n3)ncc2N(C)C1=O InChI=1S/C28H36N8O4/c1-4-21-27(37)34(2)22-16-29-28(32-26(22)36(21)19-7-5-6-8-19)30-20-10-9-18(15-23(20)38-3)25-31-24(40-33-25)17-35-11-13-39-14-12-35/h9-10,15-16,19,21H,4-8,11-14,17H2,1-3H3,(H,29,30,32)/t21-/m1/s1 SFYYLBLKRNQYSN-OAQYLSRUSA-N 50626600 CHEMBL5426079 Serine/threonine-protein kinase PLK1 Homo sapiens 0.760000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626600&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556852 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCNCC4)n3)ncc2N(C)C1=O InChI=1S/C28H37N9O3/c1-4-21-27(38)35(2)22-16-30-28(33-26(22)37(21)19-7-5-6-8-19)31-20-10-9-18(15-23(20)39-3)25-32-24(40-34-25)17-36-13-11-29-12-14-36/h9-10,15-16,19,21,29H,4-8,11-14,17H2,1-3H3,(H,30,31,33)/t21-/m1/s1 CQQFCBITQKNHPX-OAQYLSRUSA-N 50626601 CHEMBL5430344 Serine/threonine-protein kinase PLK1 Homo sapiens 0.450000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626601&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556853 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCCNCC4)n3)ncc2N(C)C1=O InChI=1S/C29H39N9O3/c1-4-22-28(39)36(2)23-17-31-29(34-27(23)38(22)20-8-5-6-9-20)32-21-11-10-19(16-24(21)40-3)26-33-25(41-35-26)18-37-14-7-12-30-13-15-37/h10-11,16-17,20,22,30H,4-9,12-15,18H2,1-3H3,(H,31,32,34)/t22-/m1/s1 XSTRJMHOLBBWNN-JOCHJYFZSA-N 50626602 CHEMBL5435085 Serine/threonine-protein kinase PLK1 Homo sapiens 0.320000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626602&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556854 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4C[C@H](C)N[C@H](C)C4)n3)ncc2N(C)C1=O InChI=1S/C30H41N9O3/c1-6-23-29(40)37(4)24-14-31-30(35-28(24)39(23)21-9-7-8-10-21)33-22-12-11-20(13-25(22)41-5)27-34-26(42-36-27)17-38-15-18(2)32-19(3)16-38/h11-14,18-19,21,23,32H,6-10,15-17H2,1-5H3,(H,31,33,35)/t18-,19+,23-/m1/s1 HUJFVKRNWZXTGC-SELNLUPBSA-N 50626603 CHEMBL5398211 Serine/threonine-protein kinase PLK1 Homo sapiens 0.370000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626603&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556855 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCN(C)CC4)n3)ncc2N(C)C1=O InChI=1S/C29H39N9O3/c1-5-22-28(39)36(3)23-17-30-29(33-27(23)38(22)20-8-6-7-9-20)31-21-11-10-19(16-24(21)40-4)26-32-25(41-34-26)18-37-14-12-35(2)13-15-37/h10-11,16-17,20,22H,5-9,12-15,18H2,1-4H3,(H,30,31,33)/t22-/m1/s1 XGCKMZYZRHDEBU-JOCHJYFZSA-N 50626604 CHEMBL5405803 Serine/threonine-protein kinase PLK1 Homo sapiens 0.910000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626604&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556856 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCN(CC)CC4)n3)ncc2N(C)C1=O InChI=1S/C30H41N9O3/c1-5-23-29(40)36(3)24-18-31-30(34-28(24)39(23)21-9-7-8-10-21)32-22-12-11-20(17-25(22)41-4)27-33-26(42-35-27)19-38-15-13-37(6-2)14-16-38/h11-12,17-18,21,23H,5-10,13-16,19H2,1-4H3,(H,31,32,34)/t23-/m1/s1 PXIVJKRPGLBHPH-HSZRJFAPSA-N 50626605 CHEMBL5440471 Serine/threonine-protein kinase PLK1 Homo sapiens 0.550000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626605&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556857 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)-c3noc(CN4CCN(CCO)CC4)n3)ncc2N(C)C1=O InChI=1S/C30H41N9O4/c1-4-23-29(41)36(2)24-18-31-30(34-28(24)39(23)21-7-5-6-8-21)32-22-10-9-20(17-25(22)42-3)27-33-26(43-35-27)19-38-13-11-37(12-14-38)15-16-40/h9-10,17-18,21,23,40H,4-8,11-16,19H2,1-3H3,(H,31,32,34)/t23-/m1/s1 ZAWVYSMIKFNSAS-HSZRJFAPSA-N 50626606 CHEMBL5415945 Serine/threonine-protein kinase PLK1 Homo sapiens 0.260000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50626606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50626606&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51556858 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Serine/threonine-protein kinase PLK1 Homo sapiens 0.510000 ChEMBL 10.1016/j.ejmech.2023.115242 10.7270/Q28C9VZ6 17433696 Bostrom, J; Berggren, K; Elebring, T; Greasley, PJ; Wilstermann, M AstraZeneca R&D Mölndal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540814 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C47H54N12O9/c1-4-19-57-43(63)33-28-50-46(54-41(33)59(57)37-10-6-9-36(52-37)47(2,3)66)51-30-11-13-31(14-12-30)56-22-20-55(21-23-56)29-39(61)49-18-25-68-27-26-67-24-17-48-34-8-5-7-32-40(34)45(65)58(44(32)64)35-15-16-38(60)53-42(35)62/h4-14,28,35,48,66H,1,15-27,29H2,2-3H3,(H,49,61)(H,50,51,54)(H,53,60,62) QVDNFGZSXCSHGE-UHFFFAOYSA-N 50619737 CHEMBL5412009 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619737&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540815 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCOCCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C49H58N12O10/c1-4-19-59-45(65)35-30-52-48(56-43(35)61(59)39-10-6-9-38(54-39)49(2,3)68)53-32-11-13-33(14-12-32)58-22-20-57(21-23-58)31-41(63)51-18-25-70-27-29-71-28-26-69-24-17-50-36-8-5-7-34-42(36)47(67)60(46(34)66)37-15-16-40(62)55-44(37)64/h4-14,30,37,50,68H,1,15-29,31H2,2-3H3,(H,51,63)(H,52,53,56)(H,55,62,64) HLXZWTDLTOPFFS-UHFFFAOYSA-N 50619738 CHEMBL5440332 Serine/threonine-protein kinase PLK1 Homo sapiens 2348 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619738&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540816 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCOCCOCCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C51H62N12O11/c1-4-19-61-47(67)37-32-54-50(58-45(37)63(61)41-10-6-9-40(56-41)51(2,3)70)55-34-11-13-35(14-12-34)60-22-20-59(21-23-60)33-43(65)53-18-25-72-27-29-74-31-30-73-28-26-71-24-17-52-38-8-5-7-36-44(38)49(69)62(48(36)68)39-15-16-42(64)57-46(39)66/h4-14,32,39,52,70H,1,15-31,33H2,2-3H3,(H,53,65)(H,54,55,58)(H,57,64,66) YLVGLAFEPVMTMZ-UHFFFAOYSA-N 50619739 CHEMBL5403604 Serine/threonine-protein kinase PLK1 Homo sapiens 516 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619739&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540817 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCOCCOCCOCCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C53H66N12O12/c1-4-19-63-49(69)39-34-56-52(60-47(39)65(63)43-10-6-9-42(58-43)53(2,3)72)57-36-11-13-37(14-12-36)62-22-20-61(21-23-62)35-45(67)55-18-25-74-27-29-76-31-33-77-32-30-75-28-26-73-24-17-54-40-8-5-7-38-46(40)51(71)64(50(38)70)41-15-16-44(66)59-48(41)68/h4-14,34,41,54,72H,1,15-33,35H2,2-3H3,(H,55,67)(H,56,57,60)(H,59,66,68) FJMFYJHRMITYEK-UHFFFAOYSA-N 50619740 CHEMBL5412194 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619740&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540818 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C55H70N12O13/c1-4-19-65-51(71)41-36-58-54(62-49(41)67(65)45-10-6-9-44(60-45)55(2,3)74)59-38-11-13-39(14-12-38)64-22-20-63(21-23-64)37-47(69)57-18-25-76-27-29-78-31-33-80-35-34-79-32-30-77-28-26-75-24-17-56-42-8-5-7-40-48(42)53(73)66(52(40)72)43-15-16-46(68)61-50(43)70/h4-14,36,43,56,74H,1,15-35,37H2,2-3H3,(H,57,69)(H,58,59,62)(H,61,68,70) FTRMYQQVSZDVEY-UHFFFAOYSA-N 50619741 CHEMBL5420142 Serine/threonine-protein kinase PLK1 Homo sapiens 3765 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619741&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540819 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C57H74N12O14/c1-4-19-67-53(73)43-38-60-56(64-51(43)69(67)47-10-6-9-46(62-47)57(2,3)76)61-40-11-13-41(14-12-40)66-22-20-65(21-23-66)39-49(71)59-18-25-78-27-29-80-31-33-82-35-37-83-36-34-81-32-30-79-28-26-77-24-17-58-44-8-5-7-42-50(44)55(75)68(54(42)74)45-15-16-48(70)63-52(45)72/h4-14,38,45,58,76H,1,15-37,39H2,2-3H3,(H,59,71)(H,60,61,64)(H,63,70,72) YVWDDCWVLNGLAT-UHFFFAOYSA-N 50619742 CHEMBL5425172 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619742&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540820 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C59H78N12O15/c1-4-19-69-55(75)45-40-62-58(66-53(45)71(69)49-10-6-9-48(64-49)59(2,3)78)63-42-11-13-43(14-12-42)68-22-20-67(21-23-68)41-51(73)61-18-25-80-27-29-82-31-33-84-35-37-86-39-38-85-36-34-83-32-30-81-28-26-79-24-17-60-46-8-5-7-44-52(46)57(77)70(56(44)76)47-15-16-50(72)65-54(47)74/h4-14,40,47,60,78H,1,15-39,41H2,2-3H3,(H,61,73)(H,62,63,66)(H,65,72,74) NPOKVSCCTXUXCZ-UHFFFAOYSA-N 50619743 CHEMBL5434663 Serine/threonine-protein kinase PLK1 Homo sapiens 2086 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619743&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540821 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C44H48N12O7/c1-4-20-54-40(60)30-25-47-43(51-38(30)56(54)34-11-6-10-33(49-34)44(2,3)63)48-27-12-14-28(15-13-27)53-23-21-52(22-24-53)26-36(58)46-19-7-18-45-31-9-5-8-29-37(31)42(62)55(41(29)61)32-16-17-35(57)50-39(32)59/h4-6,8-15,25,32,45,63H,1,7,16-24,26H2,2-3H3,(H,46,58)(H,47,48,51)(H,50,57,59) MRIHJRDMWTWBBJ-UHFFFAOYSA-N 50619744 CHEMBL5406356 Serine/threonine-protein kinase PLK1 Homo sapiens 2428 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619744&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540822 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C45H50N12O7/c1-4-21-55-41(61)31-26-48-44(52-39(31)57(55)35-12-8-11-34(50-35)45(2,3)64)49-28-13-15-29(16-14-28)54-24-22-53(23-25-54)27-37(59)47-20-6-5-19-46-32-10-7-9-30-38(32)43(63)56(42(30)62)33-17-18-36(58)51-40(33)60/h4,7-16,26,33,46,64H,1,5-6,17-25,27H2,2-3H3,(H,47,59)(H,48,49,52)(H,51,58,60) PVTVHNBVKKESBO-UHFFFAOYSA-N 50619745 CHEMBL5440440 Serine/threonine-protein kinase PLK1 Homo sapiens 2153 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619745&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540823 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C46H52N12O7/c1-4-22-56-42(62)32-27-49-45(53-40(32)58(56)36-13-9-12-35(51-36)46(2,3)65)50-29-14-16-30(17-15-29)55-25-23-54(24-26-55)28-38(60)48-21-7-5-6-20-47-33-11-8-10-31-39(33)44(64)57(43(31)63)34-18-19-37(59)52-41(34)61/h4,8-17,27,34,47,65H,1,5-7,18-26,28H2,2-3H3,(H,48,60)(H,49,50,53)(H,52,59,61) IILBQLFZZMUWAA-UHFFFAOYSA-N 50619746 CHEMBL5403903 Serine/threonine-protein kinase PLK1 Homo sapiens 1195 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619746&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540824 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C47H54N12O7/c1-4-23-57-43(63)33-28-50-46(54-41(33)59(57)37-14-10-13-36(52-37)47(2,3)66)51-30-15-17-31(18-16-30)56-26-24-55(25-27-56)29-39(61)49-22-8-6-5-7-21-48-34-12-9-11-32-40(34)45(65)58(44(32)64)35-19-20-38(60)53-42(35)62/h4,9-18,28,35,48,66H,1,5-8,19-27,29H2,2-3H3,(H,49,61)(H,50,51,54)(H,53,60,62) PGTFEOIGONAMRM-UHFFFAOYSA-N 50619747 CHEMBL5414912 Serine/threonine-protein kinase PLK1 Homo sapiens 5409 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619747&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540825 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCCC(=O)NCc4ccc(CNc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)cc4)CC3)nc12 InChI=1S/C54H59N13O8/c1-4-25-65-50(72)39-32-58-53(62-48(39)67(65)43-12-8-11-42(60-43)54(2,3)75)59-36-18-20-37(21-19-36)64-28-26-63(27-29-64)33-46(70)55-24-6-5-13-44(68)57-31-35-16-14-34(15-17-35)30-56-40-10-7-9-38-47(40)52(74)66(51(38)73)41-22-23-45(69)61-49(41)71/h4,7-12,14-21,32,41,56,75H,1,5-6,13,22-31,33H2,2-3H3,(H,55,70)(H,57,68)(H,58,59,62)(H,61,69,71) BXCIKHNWOJVIRB-UHFFFAOYSA-N 50619748 CHEMBL5421561 Serine/threonine-protein kinase PLK1 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619748&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540826 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCCC(=O)NCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C48H55N13O8/c1-4-23-59-44(66)33-28-52-47(56-42(33)61(59)37-12-8-11-36(54-37)48(2,3)69)53-30-14-16-31(17-15-30)58-26-24-57(25-27-58)29-40(64)50-20-6-5-13-38(62)51-22-21-49-34-10-7-9-32-41(34)46(68)60(45(32)67)35-18-19-39(63)55-43(35)65/h4,7-12,14-17,28,35,49,69H,1,5-6,13,18-27,29H2,2-3H3,(H,50,64)(H,51,62)(H,52,53,56)(H,55,63,65) MVZJZJSBEQPYBY-UHFFFAOYSA-N 50619749 CHEMBL5432090 Serine/threonine-protein kinase PLK1 Homo sapiens 2071 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619749&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540827 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCCC(=O)NCCOc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C48H54N12O9/c1-4-22-58-44(65)33-28-51-47(55-42(33)60(58)37-12-8-11-36(53-37)48(2,3)68)52-30-14-16-31(17-15-30)57-25-23-56(24-26-57)29-40(63)49-20-6-5-13-38(61)50-21-27-69-35-10-7-9-32-41(35)46(67)59(45(32)66)34-18-19-39(62)54-43(34)64/h4,7-12,14-17,28,34,68H,1,5-6,13,18-27,29H2,2-3H3,(H,49,63)(H,50,61)(H,51,52,55)(H,54,62,64) HMDHQASFVBNFMP-UHFFFAOYSA-N 50619750 CHEMBL5427326 Serine/threonine-protein kinase PLK1 Homo sapiens 3432 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619750&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540828 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CC(=O)NCCCCC(=O)NCc4ccc(COc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)cc4)CC3)nc12 InChI=1S/C54H58N12O9/c1-4-25-64-50(71)39-31-57-53(61-48(39)66(64)43-12-8-11-42(59-43)54(2,3)74)58-36-18-20-37(21-19-36)63-28-26-62(27-29-63)32-46(69)55-24-6-5-13-44(67)56-30-34-14-16-35(17-15-34)33-75-41-10-7-9-38-47(41)52(73)65(51(38)72)40-22-23-45(68)60-49(40)70/h4,7-12,14-21,31,40,74H,1,5-6,13,22-30,32-33H2,2-3H3,(H,55,69)(H,56,67)(H,57,58,61)(H,60,68,70) DYGBQKAGVQUDLN-UHFFFAOYSA-N 50619751 CHEMBL5405576 Serine/threonine-protein kinase PLK1 Homo sapiens 5537 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619751&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540829 CC(C)(O)c1cccc(n1)-n1n(CCC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C44H49N11O6/c1-4-5-22-53-40(58)31-27-46-43(50-38(31)55(53)35-13-9-12-34(48-35)44(2,3)61)47-28-14-16-29(17-15-28)52-25-23-51(24-26-52)21-7-6-20-45-32-11-8-10-30-37(32)42(60)54(41(30)59)33-18-19-36(56)49-39(33)57/h4,8-17,27,33,45,61H,1,5-7,18-26H2,2-3H3,(H,46,47,50)(H,49,56,57) DDZFZFNURJLLIU-UHFFFAOYSA-N 50619752 CHEMBL5431802 Serine/threonine-protein kinase PLK1 Homo sapiens 2974 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619752&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540830 CC(C)(O)c1cccc(n1)-n1n(CC=C)c(=O)c2cnc(Nc3ccc(cc3)N3CCN(CCCCCNc4cccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c45)CC3)nc12 InChI=1S/C44H49N11O6/c1-4-21-53-40(58)31-27-46-43(50-38(31)55(53)35-13-9-12-34(48-35)44(2,3)61)47-28-14-16-29(17-15-28)52-25-23-51(24-26-52)22-7-5-6-20-45-32-11-8-10-30-37(32)42(60)54(41(30)59)33-18-19-36(56)49-39(33)57/h4,8-17,27,33,45,61H,1,5-7,18-26H2,2-3H3,(H,46,47,50)(H,49,56,57) PSCPGTAHFDVFPX-UHFFFAOYSA-N 50619753 CHEMBL5393910 Serine/threonine-protein kinase PLK1 Homo sapiens 4379 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50619753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50619753&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746 51540831 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(-c2cccc(n2)C(C)(C)O)n(CC=C)c3=O)cc1 InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31) BKWJAKQVGHWELA-UHFFFAOYSA-N 50240826 AZD-1775::MK-1775::US11124518, Example AZD1775::US11248006, Compound AZD1775::US11479555, Example AZD1775::US20240182482, Compound MK-1775 Serine/threonine-protein kinase PLK1 Homo sapiens 268 ChEMBL 10.1016/j.ejmech.2022.114786 10.7270/Q2ZW1R9S 36170799 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2700&target=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240826&enzyme=Serine%2Fthreonine-protein+kinase+PLK1&column=ki&startPg=0&Increment=50&submit=Search 8X7 5VDK,5VD0,5V5Y,8BJT 24856436 386401532 1 MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS 2V5Q,4A4O,4A4L,3KB7,2YAC,4J53,4J52,1Q4K,3BZI,2OJX,2OGQ,8S31,8S30,6GY2,4HCO,4H71,4H5X,4DFW,3HIK,1UMW,1Q4O,4O56,4LKM,4RCP,4HY2,8JOY,8JOQ,8WFP,5NN2,4E9D,4E9C,4E67,3Q1I,3P37,3P36,3P35,3P34,3P2Z,3P2W,4HAB,3HIH,4LKL,4O9W,3C5L Serine/threonine-protein kinase PLK1 PLK1_HUMAN P53350 Q15153 Q99746