BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 39981 OCC1(CO)CN(Cc2c[nH]c3c2nc[nH]c3=O)C1 InChI=1S/C12H16N4O3/c17-5-12(6-18)3-16(4-12)2-8-1-13-10-9(8)14-7-15-11(10)19/h1,7,13,17-18H,2-6H2,(H,14,15,19) YYJBQFBSERVXHQ-UHFFFAOYSA-N 22103 7-{[3,3-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, 34 Purine nucleoside phosphorylase Bos taurus 0.665 7.7 22.00 C Curated from the literature by BindingDB 10.1021/jm701265n 10.7270/Q2QC01T3 18251493 aid1798156 Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22103&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 24801567 49845919 ZINC14977911 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 39982 OCC1CN(Cc2c[nH]c3c2nc[nH]c3=O)C1 InChI=1S/C11H14N4O2/c16-5-7-2-15(3-7)4-8-1-12-10-9(8)13-6-14-11(10)17/h1,6-7,12,16H,2-5H2,(H,13,14,17) FADVRXOASKIWLY-UHFFFAOYSA-N 22105 7-{[3-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, 35 Purine nucleoside phosphorylase Bos taurus 4.8 7.7 22.00 C Curated from the literature by BindingDB 10.1021/jm701265n 10.7270/Q2QC01T3 18251493 aid1798156 Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22105&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 24801568 49845921 ZINC14977914 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 39983 OC[C@H]1C[C@@H](CO)N1Cc1c[nH]c2c1nc[nH]c2=O InChI=1S/C12H16N4O3/c17-4-8-1-9(5-18)16(8)3-7-2-13-11-10(7)14-6-15-12(11)19/h2,6,8-9,13,17-18H,1,3-5H2,(H,14,15,19)/t8-,9+ ZZDOJITUEXBERC-DTORHVGOSA-N 22106 7-{[(2R,4S)-2,4-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, 40 Purine nucleoside phosphorylase Bos taurus 16 7.7 22.00 C Curated from the literature by BindingDB 10.1021/jm701265n 10.7270/Q2QC01T3 18251493 aid1798156 Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22106&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 24801740 49845922 ZINC14977917 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 39984 OC[C@H]1C[C@H](CO)N1Cc1c[nH]c2c1nc[nH]c2=O InChI=1S/C12H16N4O3/c17-4-8-1-9(5-18)16(8)3-7-2-13-11-10(7)14-6-15-12(11)19/h2,6,8-9,13,17-18H,1,3-5H2,(H,14,15,19)/t8-,9-/m1/s1 ZZDOJITUEXBERC-RKDXNWHRSA-N 22107 7-{[(2R,4R)-2,4-bis(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, (+/-) 41 Purine nucleoside phosphorylase Bos taurus 360 7.7 22.00 C Curated from the literature by BindingDB 10.1021/jm701265n 10.7270/Q2QC01T3 18251493 aid1798156 Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22107&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 24825273 49845923 ZINC14977920 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 39985 OCC1CCN1Cc1c[nH]c2c1nc[nH]c2=O InChI=1S/C11H14N4O2/c16-5-8-1-2-15(8)4-7-3-12-10-9(7)13-6-14-11(10)17/h3,6,8,12,16H,1-2,4-5H2,(H,13,14,17) QFAPYNGTGQGBFQ-UHFFFAOYSA-N 22108 7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::Azetidine based compound, (+/-) 42 Purine nucleoside phosphorylase Bos taurus 1.8 7.7 22.00 C Curated from the literature by BindingDB 10.1021/jm701265n 10.7270/Q2QC01T3 18251493 aid1798156 Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22108&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 24799122 49845924 ZINC14977926 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 39986 OC[C@H]1CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@@H]1O InChI=1S/C12H16N4O3/c17-5-8-3-16(4-9(8)18)2-7-1-13-11-10(7)14-6-15-12(11)19/h1,6,8-9,13,17-18H,2-5H2,(H,14,15,19)/t8-,9+/m1/s1 AFNHHLILYQEHKK-BDAKNGLRSA-N 22109 7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-1H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL1213653::CHEMBL269864::DADMe-ImmH,7 Purine nucleoside phosphorylase Bos taurus 1.0 7.7 22.00 C Curated from the literature by BindingDB 10.1021/jm701265n 10.7270/Q2QC01T3 18251493 aid1798156 Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22109&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 1N3I,1RSZ,2A0W,2A0X,2A0Y,2P4S,3BGS 447268 49845925 CHEMBL269864CHEMBL1213653 ZINC21290092 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50556629 Nc1nc2n(Cc3ccccc3C=C(F)P([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H13FN5O4P/c15-10(25(22,23)24)5-8-3-1-2-4-9(8)6-20-7-17-11-12(20)18-14(16)19-13(11)21/h1-5,7H,6H2,(H2,22,23,24)(H3,16,18,19,21)/p-2 AEMSKSDTIXCPHB-UHFFFAOYSA-L 50280445 (E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}-1-fluorovinylphosphonate Purine nucleoside phosphorylase Bos taurus 60 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280445&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353573 104122149 ZINC02014085 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50556630 Nc1nc2n(Cc3ccccc3C=CP([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H14N5O4P/c15-14-17-12-11(13(20)18-14)16-8-19(12)7-10-4-2-1-3-9(10)5-6-24(21,22)23/h1-6,8H,7H2,(H2,21,22,23)(H3,15,17,18,20)/p-2 ZIHFEHLASQGCRW-UHFFFAOYSA-L 50280447 (E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}vinylphosphonate Purine nucleoside phosphorylase Bos taurus 85 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280447&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353574 104122151 ZINC27327080 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50001673 Nc1nc2n(Cc3ccccc3C(F)C(F)(F)P([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H13F3N5O4P/c15-10(14(16,17)27(24,25)26)8-4-2-1-3-7(8)5-22-6-19-9-11(22)20-13(18)21-12(9)23/h1-4,6,10H,5H2,(H2,24,25,26)(H3,18,20,21,23)/p-2 CRQHLFRDYLIVLG-UHFFFAOYSA-L 50280448 2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}-1,1,2-trifluoroethylphosphonate Purine nucleoside phosphorylase Bos taurus 0.600000 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280448&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353579 104122152 ZINC13895885 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50001675 Nc1nc2n(Cc3ccccc3CC(F)(F)P([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H14F2N5O4P/c15-14(16,26(23,24)25)5-8-3-1-2-4-9(8)6-21-7-18-10-11(21)19-13(17)20-12(10)22/h1-4,7H,5-6H2,(H2,23,24,25)(H3,17,19,20,22)/p-2 INZHBYAJWMYEDY-UHFFFAOYSA-L 50280446 2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}-1,1-difluoroethylphosphonate Purine nucleoside phosphorylase Bos taurus 4 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280446&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353578 104122150 ZINC02014086 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50001676 Nc1nc2n(Cc3ccccc3C=CP([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H14N5O4P/c15-14-17-12-11(13(20)18-14)16-8-19(12)7-10-4-2-1-3-9(10)5-6-24(21,22)23/h1-6,8H,7H2,(H2,21,22,23)(H3,15,17,18,20)/p-2 ZIHFEHLASQGCRW-UHFFFAOYSA-L 50280447 (E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}vinylphosphonate Purine nucleoside phosphorylase Bos taurus 0.800000 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280447&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353574 104122151 ZINC27327080 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50001677 Nc1nc2n(Cc3ccccc3C=C(F)P([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H13FN5O4P/c15-10(25(22,23)24)5-8-3-1-2-4-9(8)6-20-7-17-11-12(20)18-14(16)19-13(11)21/h1-5,7H,6H2,(H2,22,23,24)(H3,16,18,19,21)/p-2 AEMSKSDTIXCPHB-UHFFFAOYSA-L 50280445 (E)-2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}-1-fluorovinylphosphonate Purine nucleoside phosphorylase Bos taurus 0.800000 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280445&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353573 104122149 ZINC02014085 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50556631 Nc1nc2n(Cc3ccccc3CC(F)(F)P([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H14F2N5O4P/c15-14(16,26(23,24)25)5-8-3-1-2-4-9(8)6-21-7-18-10-11(21)19-13(17)20-12(10)22/h1-4,7H,5-6H2,(H2,23,24,25)(H3,17,19,20,22)/p-2 INZHBYAJWMYEDY-UHFFFAOYSA-L 50280446 2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}-1,1-difluoroethylphosphonate Purine nucleoside phosphorylase Bos taurus 200 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280446&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353578 104122150 ZINC02014086 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50556632 Nc1nc2n(Cc3ccccc3C(F)C(F)(F)P([O-])([O-])=O)cnc2c(=O)[nH]1 InChI=1S/C14H13F3N5O4P/c15-10(14(16,17)27(24,25)26)8-4-2-1-3-7(8)5-22-6-19-9-11(22)20-13(18)21-12(9)23/h1-4,6,10H,5H2,(H2,24,25,26)(H3,18,20,21,23)/p-2 CRQHLFRDYLIVLG-UHFFFAOYSA-L 50280448 2-{2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]phenyl}-1,1,2-trifluoroethylphosphonate Purine nucleoside phosphorylase Bos taurus 100 ChEMBL 10.1016/S0960-894X(00)80157-2 10.7270/Q2WD412N Halazy, S; Eggenspiller, A; Ehrhard, A; Danzin, C TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50280448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50280448&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44353579 104122152 ZINC13895885 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077693 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1=CCCCC1 InChI=1S/C12H14N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h4,6,14H,1-3,5H2,(H3,13,15,16,17) VWZFXCVUFKBULH-UHFFFAOYSA-N 50048050 2-Amino-7-cyclohex-1-enyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL301203 Purine nucleoside phosphorylase Bos taurus 19000 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048050&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646025 103978583 CHEMBL301203 ZINC13798508 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077695 CC1CCCC(Cc2c[nH]c3c2nc(N)[nH]c3=O)C1 InChI=1S/C14H20N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h7-9,16H,2-6H2,1H3,(H3,15,17,18,19) YUGANDNTRSYZMH-UHFFFAOYSA-N 50048046 2-Amino-7-(3-methyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56540 Purine nucleoside phosphorylase Bos taurus 820 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048046&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646015 103978579 CHEMBL56540 ZINC13798477 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077699 Nc1nc2c(CC3CCCO3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4O2/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) FFFFDFWPELSFCP-UHFFFAOYSA-N 50048048 2-Amino-7-(tetrahydro-furan-2-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL262145 Purine nucleoside phosphorylase Bos taurus 70 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048048&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646018 103978581 CHEMBL262145 ZINC13831884 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077703 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1CCCCC1 InChI=1S/C12H16N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) ROKDRQZSBSPKDT-UHFFFAOYSA-N 50048047 2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL54489 Purine nucleoside phosphorylase Bos taurus 150000 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048047&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646026 103978580 CHEMBL54489 ZINC13798505 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060163 Nc1nc2c(CC3CCCSS3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4OS2/c12-11-14-8-6(4-7-2-1-3-17-18-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) PIEVCILNJBJSRY-UHFFFAOYSA-N 50048045 2-Amino-7-[1,2]dithian-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL57218 Purine nucleoside phosphorylase Bos taurus 18 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048045&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646024 103978578 CHEMBL57218 ZINC13831881 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060165 Nc1nc2c(CC3CCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H16N4O/c13-12-15-9-8(5-7-3-1-2-4-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) YFJGSWQEEMSQEI-UHFFFAOYSA-N 50039562 2-Amino-7-cyclopentylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56593 Purine nucleoside phosphorylase Bos taurus 29 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039562&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646012 103946759 CHEMBL56593 ZINC13738105 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060166 CC1CCCC(Cc2c[nH]c3c2nc(N)[nH]c3=O)C1 InChI=1S/C14H20N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h7-9,16H,2-6H2,1H3,(H3,15,17,18,19) YUGANDNTRSYZMH-UHFFFAOYSA-N 50048046 2-Amino-7-(3-methyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56540 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048046&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646015 103978579 CHEMBL56540 ZINC13798477 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060167 Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H18N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h7-8,15H,1-6H2,(H3,14,16,17,18) ZEWVUZXPYBZKSJ-UHFFFAOYSA-N 50042800 2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL299952 Purine nucleoside phosphorylase Bos taurus 47 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042800&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10514585 103974365 CHEMBL299952 ZINC13798451 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060168 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1CCCCC1 InChI=1S/C12H16N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) ROKDRQZSBSPKDT-UHFFFAOYSA-N 50048047 2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL54489 Purine nucleoside phosphorylase Bos taurus 1300 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048047&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646026 103978580 CHEMBL54489 ZINC13798505 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060170 Nc1nc2c(CC3CCCCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C14H20N4O/c15-14-17-11-10(8-16-12(11)13(19)18-14)7-9-5-3-1-2-4-6-9/h8-9,16H,1-7H2,(H3,15,17,18,19) NUQBTQMVHRKTRO-UHFFFAOYSA-N 50048043 2-Amino-7-cycloheptylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL297891 Purine nucleoside phosphorylase Bos taurus 860 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048043&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646013 103978576 CHEMBL297891 ZINC13831882 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060171 Nc1nc2c(CC3CCCC(C3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H17F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h6-7,9,19H,1-5H2,(H3,18,20,21,22) SBRMCLIMRSOKFU-UHFFFAOYSA-N 50048053 2-Amino-7-(3-trifluoromethyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55454 Purine nucleoside phosphorylase Bos taurus 800 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048053&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646016 103978586 CHEMBL55454 ZINC13798462 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060172 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1=CCCCC1 InChI=1S/C12H14N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h4,6,14H,1-3,5H2,(H3,13,15,16,17) VWZFXCVUFKBULH-UHFFFAOYSA-N 50048050 2-Amino-7-cyclohex-1-enyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL301203 Purine nucleoside phosphorylase Bos taurus 1900 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048050&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646025 103978583 CHEMBL301203 ZINC13798508 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060174 Nc1nc2c(CC3CCCO3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4O2/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) FFFFDFWPELSFCP-UHFFFAOYSA-N 50048048 2-Amino-7-(tetrahydro-furan-2-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL262145 Purine nucleoside phosphorylase Bos taurus 300 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048048&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646018 103978581 CHEMBL262145 ZINC13831884 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059463 Nc1nc2c(Cc3ccc(Cl)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UUGHFFUUNJFXJA-UHFFFAOYSA-N 50046219 2-Amino-7-(4-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79410 Purine nucleoside phosphorylase Bos taurus 380 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046219&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778126 103977041 CHEMBL79410 ZINC13798437 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059465 Nc1nc2C(Cc3ccccc3)CNc2c(=O)[nH]1 InChI=1S/C13H14N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,9,15H,6-7H2,(H3,14,16,17,18) SRZKQXMAAAAYDI-UHFFFAOYSA-N 50046234 2-Amino-7-benzyl-3,4a,5,7a-tetrahydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL161609 Purine nucleoside phosphorylase Bos taurus 100 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046234&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929343 103977056 CHEMBL161609 ZINC49925405 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059466 Nc1nc2c(Cc3ccco3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4O2/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) YABIPPNOXRKWBX-UHFFFAOYSA-N 50046240 2-Amino-7-furan-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351205 Purine nucleoside phosphorylase Bos taurus 313 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046240&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11776004 103977062 CHEMBL351205 ZINC13861147 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059467 Nc1nc2C(Cc3ccsc3)CNc2c(=O)[nH]1 InChI=1S/C11H12N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,5,7,13H,3-4H2,(H3,12,14,15,16) SKEKJWCUZBODGF-UHFFFAOYSA-N 50046239 2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159640 Purine nucleoside phosphorylase Bos taurus 15 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046239&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929345 103977061 CHEMBL159640 ZINC27757076 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059468 Nc1nc2c(Cc3cccc(O)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)4-7-2-1-3-9(18)5-7/h1-3,5-6,15,18H,4H2,(H3,14,16,17,19) KFEIVJHPUHYGLV-UHFFFAOYSA-N 50046213 2-Amino-7-(3-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL82087 Purine nucleoside phosphorylase Bos taurus 70 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046213&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10467587 103977035 CHEMBL82087 ZINC13798445 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059471 Nc1nc2N(Cc3cccs3)CNc2c(=O)[nH]1 InChI=1S/C10H11N5OS/c11-10-13-8-7(9(16)14-10)12-5-15(8)4-6-2-1-3-17-6/h1-3,12H,4-5H2,(H3,11,13,14,16) UPNZQUYQZWHTQQ-UHFFFAOYSA-N 50046226 2-Amino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL345655 Purine nucleoside phosphorylase Bos taurus 2000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046226&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374593 103977048 CHEMBL345655 ZINC27761709 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059472 Nc1nc2c(Cc3cccc(Oc4ccccc4)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C19H16N4O2/c20-19-22-16-13(11-21-17(16)18(24)23-19)9-12-5-4-8-15(10-12)25-14-6-2-1-3-7-14/h1-8,10-11,21H,9H2,(H3,20,22,23,24) SZLVNGWVKLCDQQ-UHFFFAOYSA-N 50046244 2-Amino-7-(3-phenoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159471 Purine nucleoside phosphorylase Bos taurus 147 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046244&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374526 103977066 CHEMBL159471 ZINC27753733 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059473 Nc1nc2c(Cc3ccc(Cl)c(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H10Cl2N4O/c14-8-2-1-6(4-9(8)15)3-7-5-17-11-10(7)18-13(16)19-12(11)20/h1-2,4-5,17H,3H2,(H3,16,18,19,20) FVPGRDMKNFHMAJ-UHFFFAOYSA-N 50046225 2-Amino-7-(3,4-dichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL160043 Purine nucleoside phosphorylase Bos taurus 17 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046225&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10063910 103977047 CHEMBL160043 ZINC13861140 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059476 Nc1nc2c(Cc3cccc(c3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H11F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h1-3,5-6,19H,4H2,(H3,18,20,21,22) CBTABLJYKHBPFF-UHFFFAOYSA-N 50046232 2-Amino-7-(3-trifluoromethyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL354926 Purine nucleoside phosphorylase Bos taurus 36 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046232&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10040910 103977054 CHEMBL354926 ZINC13861144 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059478 Nc1nc2c(Cc3cccc(F)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11FN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) WOWBUNTUMYSYSI-UHFFFAOYSA-N 50046233 2-Amino-7-(3-fluoro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159908 Purine nucleoside phosphorylase Bos taurus 220 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046233&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10061045 103977055 CHEMBL159908 ZINC13861143 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059479 Nc1nc2c(Cc3ccc(O)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-1-3-9(18)4-2-7/h1-4,6,15,18H,5H2,(H3,14,16,17,19) PZTAPFWQMIZJNG-UHFFFAOYSA-N 50046220 2-Amino-7-(4-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81731 Purine nucleoside phosphorylase Bos taurus 2300 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046220&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10106443 103977042 CHEMBL81731 ZINC13798448 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059481 Nc1nc2c(Cc3cccs3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) FJABJEFAQUFECU-UHFFFAOYSA-N 50046242 2-Amino-7-thiophen-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351815 Purine nucleoside phosphorylase Bos taurus 150 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046242&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10083264 103977064 CHEMBL351815 ZINC13861141 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059484 Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3H,4H2,(H2,12,13)(H3,11,14,15,17) HANOSGYMKMNFON-UHFFFAOYSA-N 50005795 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL285627::PD-119229-2 Purine nucleoside phosphorylase Bos taurus 160 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005795&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 147062 103919220 CHEMBL285627 ZINC06093612 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060164 Nc1nc2c(CC3CCCCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C14H20N4O/c15-14-17-11-10(8-16-12(11)13(19)18-14)7-9-5-3-1-2-4-6-9/h8-9,16H,1-7H2,(H3,15,17,18,19) NUQBTQMVHRKTRO-UHFFFAOYSA-N 50048043 2-Amino-7-cycloheptylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL297891 Purine nucleoside phosphorylase Bos taurus 30 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048043&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646013 103978576 CHEMBL297891 ZINC13831882 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060169 Nc1nc2c(CC3CCCC(C3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H17F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h6-7,9,19H,1-5H2,(H3,18,20,21,22) SBRMCLIMRSOKFU-UHFFFAOYSA-N 50048053 2-Amino-7-(3-trifluoromethyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55454 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048053&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646016 103978586 CHEMBL55454 ZINC13798462 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060173 Nc1nc2c(CC3CCCNC3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H17N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h6-7,14-15H,1-5H2,(H3,13,16,17,18) IWUYDPBODHDBML-UHFFFAOYSA-N 50048049 2-Amino-7-piperidin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL51900 Purine nucleoside phosphorylase Bos taurus 1000 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048049&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 22323337 103978582 CHEMBL51900 ZINC13831887 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50060175 Nc1nc2c(CC3C4CC5CC(C4)CC3C5)c[nH]c2c(=O)[nH]1 InChI=1S/C17H22N4O/c18-17-20-14-12(7-19-15(14)16(22)21-17)6-13-10-2-8-1-9(4-10)5-11(13)3-8/h7-11,13,19H,1-6H2,(H3,18,20,21,22) TUTCAVGXGSYOJT-UHFFFAOYSA-N 50048051 7-Adamantan-2-ylmethyl-2-amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL298954 Purine nucleoside phosphorylase Bos taurus 2500 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048051&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646014 103978584 CHEMBL298954 ZINC13831885 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077678 Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) YYFKQPPPFQYGFO-UHFFFAOYSA-N 50048044 2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55675 Purine nucleoside phosphorylase Bos taurus 11 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048044&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646023 103978577 CHEMBL55675 ZINC13798466 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077681 Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H18N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h7-8,15H,1-6H2,(H3,14,16,17,18) ZEWVUZXPYBZKSJ-UHFFFAOYSA-N 50042800 2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL299952 Purine nucleoside phosphorylase Bos taurus 2100 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042800&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10514585 103974365 CHEMBL299952 ZINC13798451 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077682 Nc1[nH]c2c(nc(N)[nH]c2=O)c1CC1CCCCC1 InChI=1S/C13H19N5O/c14-11-8(6-7-4-2-1-3-5-7)9-10(16-11)12(19)18-13(15)17-9/h7,16H,1-6,14H2,(H3,15,17,18,19) GSXPTTGZKTYVMY-UHFFFAOYSA-N 50048052 2,6-Diamino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL292132 Purine nucleoside phosphorylase Bos taurus 6600 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048052&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646020 103978585 CHEMBL292132 ZINC13798510 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077684 Nc1nc2c(CC3CCCSS3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4OS2/c12-11-14-8-6(4-7-2-1-3-17-18-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) PIEVCILNJBJSRY-UHFFFAOYSA-N 50048045 2-Amino-7-[1,2]dithian-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL57218 Purine nucleoside phosphorylase Bos taurus 200 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048045&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646024 103978578 CHEMBL57218 ZINC13831881 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077688 Nc1nc2c(CC3CCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H16N4O/c13-12-15-9-8(5-7-3-1-2-4-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) YFJGSWQEEMSQEI-UHFFFAOYSA-N 50039562 2-Amino-7-cyclopentylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56593 Purine nucleoside phosphorylase Bos taurus 1800 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039562&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646012 103946759 CHEMBL56593 ZINC13738105 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074822 Nc1nc2cc([nH]c2c(=O)[nH]1)-c1cccnc1 InChI=1S/C11H9N5O/c12-11-15-8-4-7(6-2-1-3-13-5-6)14-9(8)10(17)16-11/h1-5,14H,(H3,12,15,16,17) GUCIPAXWIAOMKH-UHFFFAOYSA-N 50046229 2-Amino-6-pyridin-3-yl-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL352454 Purine nucleoside phosphorylase Bos taurus 0.160000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046229&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 53857398 103977051 CHEMBL352454 ZINC27752513 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074825 Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h1-3,5-6,15H,4H2,(H3,13,16,17,18) DOHVAKFYAHLCJP-UHFFFAOYSA-N 50039542 2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL311300 Purine nucleoside phosphorylase Bos taurus 190 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039542&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search BC3 3DJF 60817 103946740 CHEMBL311300 ZINC05420970 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074828 Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QDPMHXUWMPNTEQ-UHFFFAOYSA-N 50039544 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79784 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039544&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 3035609 103946742 CHEMBL79784 ZINC00005543 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074832 Nc1nc2c(Cc3cc(Cl)cc(Cl)c3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H9Cl3N4O/c14-7-2-5(9(16)8(15)3-7)1-6-4-18-11-10(6)19-13(17)20-12(11)21/h2-4,18H,1H2,(H3,17,19,20,21) RZCKSKZVJBTDGA-UHFFFAOYSA-N 50046228 2-Amino-7-(2,3,5-trichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL158599 Purine nucleoside phosphorylase Bos taurus 240 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046228&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11725010 103977050 CHEMBL158599 ZINC13861148 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074837 Nc1nc2c(Cc3ccccc3O)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-3-1-2-4-9(7)18/h1-4,6,15,18H,5H2,(H3,14,16,17,19) RQCPZIFPORZYES-UHFFFAOYSA-N 50046237 2-Amino-7-(2-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL309679 Purine nucleoside phosphorylase Bos taurus 2000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046237&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11777160 103977059 CHEMBL309679 ZINC13798502 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074841 NC1Nc2c(nc(N)[nH]c2=O)C1Cc1ccsc1 InChI=1S/C11H13N5OS/c12-9-6(3-5-1-2-18-4-5)7-8(14-9)10(17)16-11(13)15-7/h1-2,4,6,9,14H,3,12H2,(H3,13,15,16,17) XGAPPXKWFKSYLM-UHFFFAOYSA-N 50046238 2,8-Diamino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159758 Purine nucleoside phosphorylase Bos taurus 0.630000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046238&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929344 103977060 CHEMBL159758 ZINC49916772 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074843 Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) CULKYGOMWFATON-UHFFFAOYSA-N 50042804 2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(3-chlorobenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310364 Purine nucleoside phosphorylase Bos taurus 150 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042804&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778127 103974369 CHEMBL310364 ZINC13798439 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074847 Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18) ZBEJFMQAPZKPCM-UHFFFAOYSA-N 50039547 2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310202 Purine nucleoside phosphorylase Bos taurus 51 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039547&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9881238 103946744 CHEMBL310202 ZINC00005887 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074853 Cc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h2-5,7,16H,6H2,1H3,(H3,15,17,18,19) ICFRYSRRTZTEHG-UHFFFAOYSA-N 50046222 2-Amino-7-(3-methyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159960 Purine nucleoside phosphorylase Bos taurus 57 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046222&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10060867 103977044 CHEMBL159960 ZINC13861145 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074857 COc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O2/c1-20-10-4-2-3-8(6-10)5-9-7-16-12-11(9)17-14(15)18-13(12)19/h2-4,6-7,16H,5H2,1H3,(H3,15,17,18,19) DOQAZHCUONJLMW-UHFFFAOYSA-N 50046214 2-Amino-7-(3-methoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL162751 Purine nucleoside phosphorylase Bos taurus 660 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046214&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10400926 103977036 CHEMBL162751 ZINC13861146 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074863 Nc1nc2c(Cc3ccc(I)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11IN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) GFFQSWANLMANPJ-UHFFFAOYSA-N 50046245 2-Amino-7-(4-iodo-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL349615 Purine nucleoside phosphorylase Bos taurus 270 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046245&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10316804 103977067 CHEMBL349615 ZINC13861142 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074866 Nc1nc2c(Cc3ccccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-4-2-1-3-7(9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UJAUASVSBLUQKK-UHFFFAOYSA-N 50046253 2-Amino-7-(2-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81966 Purine nucleoside phosphorylase Bos taurus 2520 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046253&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10333581 103977075 CHEMBL81966 ZINC13798442 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074807 NC1Nc2c(nc(N)[nH]c2=O)N1Cc1cccs1 InChI=1S/C10H12N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3,10,13H,4,12H2,(H3,11,14,15,17) QBNDMLFHVRRQSV-UHFFFAOYSA-N 50046215 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL162255 Purine nucleoside phosphorylase Bos taurus 0.160000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046215&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374597 103977037 CHEMBL162255 ZINC27746940 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077680 Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) YYFKQPPPFQYGFO-UHFFFAOYSA-N 50048044 2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55675 Purine nucleoside phosphorylase Bos taurus 220 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048044&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646023 103978577 CHEMBL55675 ZINC13798466 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077686 Nc1nc2c(CC3CCCNC3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H17N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h6-7,14-15H,1-5H2,(H3,13,16,17,18) IWUYDPBODHDBML-UHFFFAOYSA-N 50048049 2-Amino-7-piperidin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL51900 Purine nucleoside phosphorylase Bos taurus 1000 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048049&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 22323337 103978582 CHEMBL51900 ZINC13831887 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077692 Nc1[nH]c2c(nc(N)[nH]c2=O)c1CC1CCCCC1 InChI=1S/C13H19N5O/c14-11-8(6-7-4-2-1-3-5-7)9-10(16-11)12(19)18-13(15)17-9/h7,16H,1-6,14H2,(H3,15,17,18,19) GSXPTTGZKTYVMY-UHFFFAOYSA-N 50048052 2,6-Diamino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL292132 Purine nucleoside phosphorylase Bos taurus 150000 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048052&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646020 103978585 CHEMBL292132 ZINC13798510 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50077694 Nc1nc2c(CC3C4CC5CC(C4)CC3C5)c[nH]c2c(=O)[nH]1 InChI=1S/C17H22N4O/c18-17-20-14-12(7-19-15(14)16(22)21-17)6-13-10-2-8-1-9(4-10)5-11(13)3-8/h7-11,13,19H,1-6H2,(H3,18,20,21,22) TUTCAVGXGSYOJT-UHFFFAOYSA-N 50048051 7-Adamantan-2-ylmethyl-2-amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL298954 Purine nucleoside phosphorylase Bos taurus 90 ChEMBL 10.1021/jm00065a007 10.7270/Q2WQ02WD 8515423 Secrist, JA; Niwas, S; Rose, JD; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE; Montgomery, JA BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048051&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646014 103978584 CHEMBL298954 ZINC13831885 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137112 Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H18N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h7-8,15H,1-6H2,(H3,14,16,17,18) ZEWVUZXPYBZKSJ-UHFFFAOYSA-N 50042800 2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL299952 Purine nucleoside phosphorylase Bos taurus 13.2 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042800&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10514585 103974365 CHEMBL299952 ZINC13798451 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137113 Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h1-3,5-6,15H,4H2,(H3,13,16,17,18) DOHVAKFYAHLCJP-UHFFFAOYSA-N 50039542 2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL311300 Purine nucleoside phosphorylase Bos taurus 3.1 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039542&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search BC3 3DJF 60817 103946740 CHEMBL311300 ZINC05420970 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137114 Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@H](CC(O)=O)c1cccc(Cl)c1 InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m1/s1 YDWZQOZLILLLMU-SECBINFHSA-N 50078450 (R)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionic acid::CHEMBL79132 Purine nucleoside phosphorylase Bos taurus 148.8 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078450&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44317930 103971001 CHEMBL79132 ZINC13798500 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137115 Nc1nc2c(Cc3cnccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C12H10ClN5O/c13-8-1-2-15-4-6(8)3-7-5-16-10-9(7)17-12(14)18-11(10)19/h1-2,4-5,16H,3H2,(H3,14,17,18,19) KODFPWIFWLGJSM-UHFFFAOYSA-N 50078451 2-Amino-7-(4-chloro-pyridin-3-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL78808 Purine nucleoside phosphorylase Bos taurus 35.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078451&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44317900 103971002 CHEMBL78808 ZINC13798516 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137116 Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H](CC(O)=O)c1cccc(Cl)c1 InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m0/s1 YDWZQOZLILLLMU-VIFPVBQESA-N 50078452 (S)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionic acid::CHEMBL309907 Purine nucleoside phosphorylase Bos taurus 4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078452&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 192298 103971003 CHEMBL309907 ZINC21290085 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137117 Nc1nc2c(Cc3ccc(O)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-1-3-9(18)4-2-7/h1-4,6,15,18H,5H2,(H3,14,16,17,19) PZTAPFWQMIZJNG-UHFFFAOYSA-N 50046220 2-Amino-7-(4-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81731 Purine nucleoside phosphorylase Bos taurus 35 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046220&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10106443 103977042 CHEMBL81731 ZINC13798448 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137118 Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) CULKYGOMWFATON-UHFFFAOYSA-N 50042804 2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(3-chlorobenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310364 Purine nucleoside phosphorylase Bos taurus 25.8 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042804&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778127 103974369 CHEMBL310364 ZINC13798439 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137119 Nc1nc2c(Cc3ccc(Cl)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UUGHFFUUNJFXJA-UHFFFAOYSA-N 50046219 2-Amino-7-(4-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79410 Purine nucleoside phosphorylase Bos taurus 17.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046219&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778126 103977041 CHEMBL79410 ZINC13798437 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137120 Nc1nc2c(CC3CCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H16N4O/c13-12-15-9-8(5-7-3-1-2-4-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) YFJGSWQEEMSQEI-UHFFFAOYSA-N 50039562 2-Amino-7-cyclopentylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56593 Purine nucleoside phosphorylase Bos taurus 6.2 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039562&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646012 103946759 CHEMBL56593 ZINC13738105 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137121 Nc1nc2c(Cc3ccccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-4-2-1-3-7(9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UJAUASVSBLUQKK-UHFFFAOYSA-N 50046253 2-Amino-7-(2-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81966 Purine nucleoside phosphorylase Bos taurus 102.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046253&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10333581 103977075 CHEMBL81966 ZINC13798442 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137122 Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H18N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h7-8,15H,1-6H2,(H3,14,16,17,18) ZEWVUZXPYBZKSJ-UHFFFAOYSA-N 50042800 2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL299952 Purine nucleoside phosphorylase Bos taurus 21 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042800&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10514585 103974365 CHEMBL299952 ZINC13798451 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137123 Nc1nc2c(CC3CCCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H18N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h7-8,15H,1-6H2,(H3,14,16,17,18) ZEWVUZXPYBZKSJ-UHFFFAOYSA-N 50042800 2-Amino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL299952 Purine nucleoside phosphorylase Bos taurus 6.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042800&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10514585 103974365 CHEMBL299952 ZINC13798451 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137124 Nc1nc2c(Cc3ccccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-4-2-1-3-7(9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UJAUASVSBLUQKK-UHFFFAOYSA-N 50046253 2-Amino-7-(2-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81966 Purine nucleoside phosphorylase Bos taurus 14.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046253&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10333581 103977075 CHEMBL81966 ZINC13798442 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137125 Nc1nc2c(Cc3ccccc3O)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-3-1-2-4-9(7)18/h1-4,6,15,18H,5H2,(H3,14,16,17,19) RQCPZIFPORZYES-UHFFFAOYSA-N 50046237 2-Amino-7-(2-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL309679 Purine nucleoside phosphorylase Bos taurus 182.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046237&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11777160 103977059 CHEMBL309679 ZINC13798502 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137126 Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18) ZBEJFMQAPZKPCM-UHFFFAOYSA-N 50039547 2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310202 Purine nucleoside phosphorylase Bos taurus 11 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039547&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9881238 103946744 CHEMBL310202 ZINC00005887 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137127 Nc1nc2c(Cc3ccncc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(5-7-1-3-14-4-2-7)6-15-10(9)11(18)17-12/h1-4,6,15H,5H2,(H3,13,16,17,18) MABQSTXKBLIFAR-UHFFFAOYSA-N 50078453 2-Amino-7-pyridin-4-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-4-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL79865 Purine nucleoside phosphorylase Bos taurus 16.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078453&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15115445 103971004 CHEMBL79865 ZINC13798513 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137128 CC1CCCC(Cc2c[nH]c3c2nc(N)[nH]c3=O)C1 InChI=1S/C14H20N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h7-9,16H,2-6H2,1H3,(H3,15,17,18,19) YUGANDNTRSYZMH-UHFFFAOYSA-N 50048046 2-Amino-7-(3-methyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56540 Purine nucleoside phosphorylase Bos taurus 11.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048046&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646015 103978579 CHEMBL56540 ZINC13798477 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137129 Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC(O)=O)c1ccccc1 InChI=1S/C15H14N4O3/c16-15-18-12-10(7-17-13(12)14(22)19-15)9(6-11(20)21)8-4-2-1-3-5-8/h1-5,7,9,17H,6H2,(H,20,21)(H3,16,18,19,22) VEDWLJMIJINPSJ-UHFFFAOYSA-N 50042799 3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-phenyl-propionic acid::CHEMBL79460 Purine nucleoside phosphorylase Bos taurus 9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042799&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 19692438 103974364 CHEMBL79460 ZINC13798480 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137130 Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) CULKYGOMWFATON-UHFFFAOYSA-N 50042804 2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(3-chlorobenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310364 Purine nucleoside phosphorylase Bos taurus 4.3 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042804&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778127 103974369 CHEMBL310364 ZINC13798439 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137131 Nc1nc2c(Cc3ccccc3O)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-3-1-2-4-9(7)18/h1-4,6,15,18H,5H2,(H3,14,16,17,19) RQCPZIFPORZYES-UHFFFAOYSA-N 50046237 2-Amino-7-(2-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL309679 Purine nucleoside phosphorylase Bos taurus 84 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046237&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11777160 103977059 CHEMBL309679 ZINC13798502 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137132 Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@H](CC(O)=O)c1cccc(Cl)c1 InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m1/s1 YDWZQOZLILLLMU-SECBINFHSA-N 50078450 (R)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionic acid::CHEMBL79132 Purine nucleoside phosphorylase Bos taurus 67.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078450&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44317930 103971001 CHEMBL79132 ZINC13798500 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137133 Oc1ncn(Cc2ccccc2)c2ncnc12 InChI=1S/C12H10N4O/c17-12-10-11(14-7-13-10)16(8-15-12)6-9-4-2-1-3-5-9/h1-5,7-8,17H,6H2 UTTXFXJKPUYGLW-UHFFFAOYSA-N 50005794 3-Benzyl-1,9-dihydro-purin-6-one::3-Benzyl-3,7-dihydro-purin-6-one::CHEMBL415041 Purine nucleoside phosphorylase Bos taurus 24645 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005794&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 250702 103919219 CHEMBL415041 ZINC13453977 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137134 Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC#N)c1cccc(Cl)c1 InChI=1S/C15H12ClN5O/c16-9-3-1-2-8(6-9)10(4-5-17)11-7-19-13-12(11)20-15(18)21-14(13)22/h1-3,6-7,10,19H,4H2,(H3,18,20,21,22) OHFLESATPONDTK-UHFFFAOYSA-N 50039549 3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionitrile::CHEMBL81839 Purine nucleoside phosphorylase Bos taurus 4.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039549&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 19692440 103946746 CHEMBL81839 ZINC13738104 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137135 Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h1-3,5-6,15H,4H2,(H3,13,16,17,18) DOHVAKFYAHLCJP-UHFFFAOYSA-N 50039542 2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL311300 Purine nucleoside phosphorylase Bos taurus 13.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039542&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search BC3 3DJF 60817 103946740 CHEMBL311300 ZINC05420970 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137136 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1CCCCC1 InChI=1S/C12H16N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) ROKDRQZSBSPKDT-UHFFFAOYSA-N 50048047 2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL54489 Purine nucleoside phosphorylase Bos taurus 332.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048047&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646026 103978580 CHEMBL54489 ZINC13798505 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137137 Nc1nc2c(CC3CCCC(C3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H17F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h6-7,9,19H,1-5H2,(H3,18,20,21,22) SBRMCLIMRSOKFU-UHFFFAOYSA-N 50048053 2-Amino-7-(3-trifluoromethyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55454 Purine nucleoside phosphorylase Bos taurus 9.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048053&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646016 103978586 CHEMBL55454 ZINC13798462 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137138 Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3H,4H2,(H2,12,13)(H3,11,14,15,17) HANOSGYMKMNFON-UHFFFAOYSA-N 50005795 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL285627::PD-119229-2 Purine nucleoside phosphorylase Bos taurus 35.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005795&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 147062 103919220 CHEMBL285627 ZINC06093612 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137139 Nc1nc2c(Cc3ccccn3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-7(5-8-3-1-2-4-14-8)6-15-10(9)11(18)17-12/h1-4,6,15H,5H2,(H3,13,16,17,18) MQHSZSQKICPGTQ-UHFFFAOYSA-N 50078454 2-Amino-7-pyridin-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-2-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL315260 Purine nucleoside phosphorylase Bos taurus 15.3 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078454&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15115444 103971005 CHEMBL315260 ZINC13798523 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137140 Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC(O)=O)c1ccccc1 InChI=1S/C15H14N4O3/c16-15-18-12-10(7-17-13(12)14(22)19-15)9(6-11(20)21)8-4-2-1-3-5-8/h1-5,7,9,17H,6H2,(H,20,21)(H3,16,18,19,22) VEDWLJMIJINPSJ-UHFFFAOYSA-N 50042799 3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-phenyl-propionic acid::CHEMBL79460 Purine nucleoside phosphorylase Bos taurus 46.8 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042799&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 19692438 103974364 CHEMBL79460 ZINC13798480 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137141 Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) YYFKQPPPFQYGFO-UHFFFAOYSA-N 50048044 2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55675 Purine nucleoside phosphorylase Bos taurus 6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048044&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646023 103978577 CHEMBL55675 ZINC13798466 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137142 Oc1ncn(Cc2ccccc2)c2ncnc12 InChI=1S/C12H10N4O/c17-12-10-11(14-7-13-10)16(8-15-12)6-9-4-2-1-3-5-9/h1-5,7-8,17H,6H2 UTTXFXJKPUYGLW-UHFFFAOYSA-N 50005794 3-Benzyl-1,9-dihydro-purin-6-one::3-Benzyl-3,7-dihydro-purin-6-one::CHEMBL415041 Purine nucleoside phosphorylase Bos taurus 49646 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005794&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 250702 103919219 CHEMBL415041 ZINC13453977 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137143 Nc1nc2c(Cc3ccc(OCc4ccccc4)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C20H18N4O2/c21-20-23-17-15(11-22-18(17)19(25)24-20)10-13-6-8-16(9-7-13)26-12-14-4-2-1-3-5-14/h1-9,11,22H,10,12H2,(H3,21,23,24,25) WCWMEVSHIYVRME-UHFFFAOYSA-N 50078455 2-Amino-7-(4-benzyloxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(4-(benzyloxy)benzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL83158 Purine nucleoside phosphorylase Bos taurus 123.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078455&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10360246 103971006 CHEMBL83158 ZINC13798483 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137144 O=c1[nH]cnc2c(Cc3ccccc3)c[nH]c12 InChI=1S/C13H11N3O/c17-13-12-11(15-8-16-13)10(7-14-12)6-9-4-2-1-3-5-9/h1-5,7-8,14H,6H2,(H,15,16,17) XTZNEYRTGZTVGE-UHFFFAOYSA-N 50039548 7-Benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81055 Purine nucleoside phosphorylase Bos taurus 24.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039548&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10353609 103946745 CHEMBL81055 ZINC00006234 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137145 Nc1nc2c(Cc3cccc(O)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)4-7-2-1-3-9(18)5-7/h1-3,5-6,15,18H,4H2,(H3,14,16,17,19) KFEIVJHPUHYGLV-UHFFFAOYSA-N 50046213 2-Amino-7-(3-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL82087 Purine nucleoside phosphorylase Bos taurus 36.1 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046213&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10467587 103977035 CHEMBL82087 ZINC13798445 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137146 Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) YYFKQPPPFQYGFO-UHFFFAOYSA-N 50048044 2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55675 Purine nucleoside phosphorylase Bos taurus 17.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048044&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646023 103978577 CHEMBL55675 ZINC13798466 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137147 Nc1nc2c(Cc3cccc(O)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)4-7-2-1-3-9(18)5-7/h1-3,5-6,15,18H,4H2,(H3,14,16,17,19) KFEIVJHPUHYGLV-UHFFFAOYSA-N 50046213 2-Amino-7-(3-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL82087 Purine nucleoside phosphorylase Bos taurus 16.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046213&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10467587 103977035 CHEMBL82087 ZINC13798445 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137148 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1=CCCCC1 InChI=1S/C12H14N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h4,6,14H,1-3,5H2,(H3,13,15,16,17) VWZFXCVUFKBULH-UHFFFAOYSA-N 50048050 2-Amino-7-cyclohex-1-enyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL301203 Purine nucleoside phosphorylase Bos taurus 1969 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048050&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646025 103978583 CHEMBL301203 ZINC13798508 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137149 Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC(O)=O)c1ccccc1 InChI=1S/C15H14N4O3/c16-15-18-12-10(7-17-13(12)14(22)19-15)9(6-11(20)21)8-4-2-1-3-5-8/h1-5,7,9,17H,6H2,(H,20,21)(H3,16,18,19,22) VEDWLJMIJINPSJ-UHFFFAOYSA-N 50042799 3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-phenyl-propionic acid::CHEMBL79460 Purine nucleoside phosphorylase Bos taurus 61 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042799&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 19692438 103974364 CHEMBL79460 ZINC13798480 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137150 Nc1nc2c(Cc3ccc(OCc4ccccc4)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C20H18N4O2/c21-20-23-17-15(11-22-18(17)19(25)24-20)10-13-6-8-16(9-7-13)26-12-14-4-2-1-3-5-14/h1-9,11,22H,10,12H2,(H3,21,23,24,25) WCWMEVSHIYVRME-UHFFFAOYSA-N 50078455 2-Amino-7-(4-benzyloxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(4-(benzyloxy)benzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL83158 Purine nucleoside phosphorylase Bos taurus 20.3 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078455&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10360246 103971006 CHEMBL83158 ZINC13798483 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137151 Nc1nc2c(Cc3ccncc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(5-7-1-3-14-4-2-7)6-15-10(9)11(18)17-12/h1-4,6,15H,5H2,(H3,13,16,17,18) MABQSTXKBLIFAR-UHFFFAOYSA-N 50078453 2-Amino-7-pyridin-4-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-4-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL79865 Purine nucleoside phosphorylase Bos taurus 25.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078453&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15115445 103971004 CHEMBL79865 ZINC13798513 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137152 Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h1-3,5-6,15H,4H2,(H3,13,16,17,18) DOHVAKFYAHLCJP-UHFFFAOYSA-N 50039542 2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL311300 Purine nucleoside phosphorylase Bos taurus 27 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039542&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search BC3 3DJF 60817 103946740 CHEMBL311300 ZINC05420970 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137153 Nc1nc2c(CC3CCCS3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H14N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h5,7,13H,1-4H2,(H3,12,14,15,16) YYFKQPPPFQYGFO-UHFFFAOYSA-N 50048044 2-Amino-7-(tetrahydro-thiophen-2-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55675 Purine nucleoside phosphorylase Bos taurus 8.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048044&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646023 103978577 CHEMBL55675 ZINC13798466 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137154 Nc1nc2nc(N)[nH]c(=O)c2[nH]1 InChI=1S/C5H6N6O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H6,6,7,8,9,10,11,12) WYDKPTZGVLTYPG-UHFFFAOYSA-N 50022243 2,8-Diamino-1,9-dihydro-purin-6-one::8-AMINOGUANINE::CHEMBL8040 Purine nucleoside phosphorylase Bos taurus 680.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022243&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 95201 103932866 CHEMBL8040 ZINC13514984 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137155 Nc1nc2c(Cc3ccc(cc3)-c3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C19H16N4O/c20-19-22-16-15(11-21-17(16)18(24)23-19)10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-9,11,21H,10H2,(H3,20,22,23,24) KYIDQZVLKXJBKP-UHFFFAOYSA-N 50078457 2-Amino-7-biphenyl-4-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79495 Purine nucleoside phosphorylase Bos taurus 546.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078457&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10591499 103971008 CHEMBL79495 ZINC13798533 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137156 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1CCCCC1 InChI=1S/C12H16N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) ROKDRQZSBSPKDT-UHFFFAOYSA-N 50048047 2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL54489 Purine nucleoside phosphorylase Bos taurus 335.3 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048047&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646026 103978580 CHEMBL54489 ZINC13798505 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137157 Cc1[nH]c2c(nc(N)[nH]c2=O)c1Cc1ccccc1 InChI=1S/C14H14N4O/c1-8-10(7-9-5-3-2-4-6-9)11-12(16-8)13(19)18-14(15)17-11/h2-6,16H,7H2,1H3,(H3,15,17,18,19) NUTPVMNRAMMBFT-UHFFFAOYSA-N 50078456 2-Amino-7-benzyl-6-methyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL311528 Purine nucleoside phosphorylase Bos taurus 67501 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078456&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 20870761 103971007 CHEMBL311528 ZINC13798519 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137158 O=c1[nH]cnc2c(Cc3ccccc3)c[nH]c12 InChI=1S/C13H11N3O/c17-13-12-11(15-8-16-13)10(7-14-12)6-9-4-2-1-3-5-9/h1-5,7-8,14H,6H2,(H,15,16,17) XTZNEYRTGZTVGE-UHFFFAOYSA-N 50039548 7-Benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81055 Purine nucleoside phosphorylase Bos taurus 18.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039548&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10353609 103946745 CHEMBL81055 ZINC00006234 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137159 CC1CCCC(Cc2c[nH]c3c2nc(N)[nH]c3=O)C1 InChI=1S/C14H20N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h7-9,16H,2-6H2,1H3,(H3,15,17,18,19) YUGANDNTRSYZMH-UHFFFAOYSA-N 50048046 2-Amino-7-(3-methyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56540 Purine nucleoside phosphorylase Bos taurus 19.2 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048046&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646015 103978579 CHEMBL56540 ZINC13798477 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137160 Nc1nc2c(Cc3ccc(O)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-1-3-9(18)4-2-7/h1-4,6,15,18H,5H2,(H3,14,16,17,19) PZTAPFWQMIZJNG-UHFFFAOYSA-N 50046220 2-Amino-7-(4-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81731 Purine nucleoside phosphorylase Bos taurus 109.1 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046220&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10106443 103977042 CHEMBL81731 ZINC13798448 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137161 Nc1nc2c(CC3CCCC(C3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H17F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h6-7,9,19H,1-5H2,(H3,18,20,21,22) SBRMCLIMRSOKFU-UHFFFAOYSA-N 50048053 2-Amino-7-(3-trifluoromethyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55454 Purine nucleoside phosphorylase Bos taurus 3.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048053&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646016 103978586 CHEMBL55454 ZINC13798462 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137162 Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@H](CC(O)=O)c1cccc(Cl)c1 InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m1/s1 YDWZQOZLILLLMU-SECBINFHSA-N 50078450 (R)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionic acid::CHEMBL79132 Purine nucleoside phosphorylase Bos taurus 245.1 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078450&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44317930 103971001 CHEMBL79132 ZINC13798500 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137163 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1=CCCCC1 InChI=1S/C12H14N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h4,6,14H,1-3,5H2,(H3,13,15,16,17) VWZFXCVUFKBULH-UHFFFAOYSA-N 50048050 2-Amino-7-cyclohex-1-enyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL301203 Purine nucleoside phosphorylase Bos taurus 862.0 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048050&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646025 103978583 CHEMBL301203 ZINC13798508 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137164 Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QDPMHXUWMPNTEQ-UHFFFAOYSA-N 50039544 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79784 Purine nucleoside phosphorylase Bos taurus 3.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039544&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 3035609 103946742 CHEMBL79784 ZINC00005543 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137165 Nc1nc2c(Cc3cnccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C12H10ClN5O/c13-8-1-2-15-4-6(8)3-7-5-16-10-9(7)17-12(14)18-11(10)19/h1-2,4-5,16H,3H2,(H3,14,17,18,19) KODFPWIFWLGJSM-UHFFFAOYSA-N 50078451 2-Amino-7-(4-chloro-pyridin-3-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL78808 Purine nucleoside phosphorylase Bos taurus 66.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078451&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44317900 103971002 CHEMBL78808 ZINC13798516 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137166 Nc1nc2c(Cc3ccc(OCc4ccccc4)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C20H18N4O2/c21-20-23-17-15(11-22-18(17)19(25)24-20)10-13-6-8-16(9-7-13)26-12-14-4-2-1-3-5-14/h1-9,11,22H,10,12H2,(H3,21,23,24,25) WCWMEVSHIYVRME-UHFFFAOYSA-N 50078455 2-Amino-7-(4-benzyloxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(4-(benzyloxy)benzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL83158 Purine nucleoside phosphorylase Bos taurus 37.8 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078455&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10360246 103971006 CHEMBL83158 ZINC13798483 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137167 Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC#N)c1cccc(Cl)c1 InChI=1S/C15H12ClN5O/c16-9-3-1-2-8(6-9)10(4-5-17)11-7-19-13-12(11)20-15(18)21-14(13)22/h1-3,6-7,10,19H,4H2,(H3,18,20,21,22) OHFLESATPONDTK-UHFFFAOYSA-N 50039549 3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionitrile::CHEMBL81839 Purine nucleoside phosphorylase Bos taurus 16.3 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039549&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 19692440 103946746 CHEMBL81839 ZINC13738104 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137168 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1CCCCC1 InChI=1S/C12H16N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) ROKDRQZSBSPKDT-UHFFFAOYSA-N 50048047 2-Amino-7-cyclohexyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL54489 Purine nucleoside phosphorylase Bos taurus 640 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048047&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646026 103978580 CHEMBL54489 ZINC13798505 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137169 Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QDPMHXUWMPNTEQ-UHFFFAOYSA-N 50039544 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79784 Purine nucleoside phosphorylase Bos taurus 22.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039544&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 3035609 103946742 CHEMBL79784 ZINC00005543 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137170 Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18) ZBEJFMQAPZKPCM-UHFFFAOYSA-N 50039547 2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310202 Purine nucleoside phosphorylase Bos taurus 3.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039547&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9881238 103946744 CHEMBL310202 ZINC00005887 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137171 Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H](CC(O)=O)c1cccc(Cl)c1 InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m0/s1 YDWZQOZLILLLMU-VIFPVBQESA-N 50078452 (S)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionic acid::CHEMBL309907 Purine nucleoside phosphorylase Bos taurus 22 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078452&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 192298 103971003 CHEMBL309907 ZINC21290085 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137172 Cc1[nH]c2c(nc(N)[nH]c2=O)c1Cc1ccccc1 InChI=1S/C14H14N4O/c1-8-10(7-9-5-3-2-4-6-9)11-12(16-8)13(19)18-14(15)17-11/h2-6,16H,7H2,1H3,(H3,15,17,18,19) NUTPVMNRAMMBFT-UHFFFAOYSA-N 50078456 2-Amino-7-benzyl-6-methyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL311528 Purine nucleoside phosphorylase Bos taurus 10321 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078456&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 20870761 103971007 CHEMBL311528 ZINC13798519 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137173 Nc1[nH]c2c(nc(N)[nH]c2=O)c1CC1CCCCC1 InChI=1S/C13H19N5O/c14-11-8(6-7-4-2-1-3-5-7)9-10(16-11)12(19)18-13(15)17-9/h7,16H,1-6,14H2,(H3,15,17,18,19) GSXPTTGZKTYVMY-UHFFFAOYSA-N 50048052 2,6-Diamino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL292132 Purine nucleoside phosphorylase Bos taurus 766 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048052&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646020 103978585 CHEMBL292132 ZINC13798510 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137174 Nc1[nH]c2c(nc(N)[nH]c2=O)c1CC1CCCCC1 InChI=1S/C13H19N5O/c14-11-8(6-7-4-2-1-3-5-7)9-10(16-11)12(19)18-13(15)17-9/h7,16H,1-6,14H2,(H3,15,17,18,19) GSXPTTGZKTYVMY-UHFFFAOYSA-N 50048052 2,6-Diamino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL292132 Purine nucleoside phosphorylase Bos taurus 1471 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048052&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646020 103978585 CHEMBL292132 ZINC13798510 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137175 Nc1nc2c(Cc3ccc(Cl)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UUGHFFUUNJFXJA-UHFFFAOYSA-N 50046219 2-Amino-7-(4-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79410 Purine nucleoside phosphorylase Bos taurus 10.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046219&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778126 103977041 CHEMBL79410 ZINC13798437 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137176 Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3H,4H2,(H2,12,13)(H3,11,14,15,17) HANOSGYMKMNFON-UHFFFAOYSA-N 50005795 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL285627::PD-119229-2 Purine nucleoside phosphorylase Bos taurus 20.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005795&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 147062 103919220 CHEMBL285627 ZINC06093612 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137177 Nc1nc2c(Cc3ccccc3O)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-3-1-2-4-9(7)18/h1-4,6,15,18H,5H2,(H3,14,16,17,19) RQCPZIFPORZYES-UHFFFAOYSA-N 50046237 2-Amino-7-(2-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL309679 Purine nucleoside phosphorylase Bos taurus 31.8 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046237&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11777160 103977059 CHEMBL309679 ZINC13798502 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137178 Nc1nc2c(Oc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H10N4O2/c13-12-15-9-8(6-14-10(9)11(17)16-12)18-7-4-2-1-3-5-7/h1-6,14H,(H3,13,15,16,17) NKOQZBQJDRYCNS-UHFFFAOYSA-N 50078459 2-Amino-7-phenoxy-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81557 Purine nucleoside phosphorylase Bos taurus 41.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078459&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10752653 103971010 CHEMBL81557 ZINC13798530 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137179 O=c1[nH]cnc2c(c[nH]c12)C(CC#N)c1cccnc1 InChI=1S/C14H11N5O/c15-4-3-10(9-2-1-5-16-6-9)11-7-17-13-12(11)18-8-19-14(13)20/h1-2,5-8,10,17H,3H2,(H,18,19,20) UDKCWSGPEYMLPY-UHFFFAOYSA-N 50078458 3-(4-Oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-pyridin-3-yl-propionitrile::CHEMBL83329 Purine nucleoside phosphorylase Bos taurus 38.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078458&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44318078 103971009 CHEMBL83329 ZINC13798528 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137180 Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18) ZBEJFMQAPZKPCM-UHFFFAOYSA-N 50039547 2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310202 Purine nucleoside phosphorylase Bos taurus 16.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039547&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9881238 103946744 CHEMBL310202 ZINC00005887 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137181 Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3H,4H2,(H2,12,13)(H3,11,14,15,17) HANOSGYMKMNFON-UHFFFAOYSA-N 50005795 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL285627::PD-119229-2 Purine nucleoside phosphorylase Bos taurus 69.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005795&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 147062 103919220 CHEMBL285627 ZINC06093612 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137182 Nc1nc2nc(N)[nH]c(=O)c2[nH]1 InChI=1S/C5H6N6O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H6,6,7,8,9,10,11,12) WYDKPTZGVLTYPG-UHFFFAOYSA-N 50022243 2,8-Diamino-1,9-dihydro-purin-6-one::8-AMINOGUANINE::CHEMBL8040 Purine nucleoside phosphorylase Bos taurus 982 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022243&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 95201 103932866 CHEMBL8040 ZINC13514984 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137183 Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QDPMHXUWMPNTEQ-UHFFFAOYSA-N 50039544 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79784 Purine nucleoside phosphorylase Bos taurus 15.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039544&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 3035609 103946742 CHEMBL79784 ZINC00005543 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137184 Nc1nc2c(Cc3cnccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C12H10ClN5O/c13-8-1-2-15-4-6(8)3-7-5-16-10-9(7)17-12(14)18-11(10)19/h1-2,4-5,16H,3H2,(H3,14,17,18,19) KODFPWIFWLGJSM-UHFFFAOYSA-N 50078451 2-Amino-7-(4-chloro-pyridin-3-ylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL78808 Purine nucleoside phosphorylase Bos taurus 134.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078451&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44317900 103971002 CHEMBL78808 ZINC13798516 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137185 Nc1nc2c(CC3CCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H16N4O/c13-12-15-9-8(5-7-3-1-2-4-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) YFJGSWQEEMSQEI-UHFFFAOYSA-N 50039562 2-Amino-7-cyclopentylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56593 Purine nucleoside phosphorylase Bos taurus 9.1 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039562&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646012 103946759 CHEMBL56593 ZINC13738105 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137186 Nc1[nH]c2c(nc(N)[nH]c2=O)c1CC1CCCCC1 InChI=1S/C13H19N5O/c14-11-8(6-7-4-2-1-3-5-7)9-10(16-11)12(19)18-13(15)17-9/h7,16H,1-6,14H2,(H3,15,17,18,19) GSXPTTGZKTYVMY-UHFFFAOYSA-N 50048052 2,6-Diamino-7-cyclohexylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL292132 Purine nucleoside phosphorylase Bos taurus 885.0 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048052&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646020 103978585 CHEMBL292132 ZINC13798510 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137187 Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) CULKYGOMWFATON-UHFFFAOYSA-N 50042804 2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(3-chlorobenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310364 Purine nucleoside phosphorylase Bos taurus 18.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042804&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778127 103974369 CHEMBL310364 ZINC13798439 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137188 Cc1[nH]c2c(nc(N)[nH]c2=O)c1Cc1ccccc1 InChI=1S/C14H14N4O/c1-8-10(7-9-5-3-2-4-6-9)11-12(16-8)13(19)18-14(15)17-11/h2-6,16H,7H2,1H3,(H3,15,17,18,19) NUTPVMNRAMMBFT-UHFFFAOYSA-N 50078456 2-Amino-7-benzyl-6-methyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL311528 Purine nucleoside phosphorylase Bos taurus 20201 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078456&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 20870761 103971007 CHEMBL311528 ZINC13798519 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137189 CC1CCCC(Cc2c[nH]c3c2nc(N)[nH]c3=O)C1 InChI=1S/C14H20N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h7-9,16H,2-6H2,1H3,(H3,15,17,18,19) YUGANDNTRSYZMH-UHFFFAOYSA-N 50048046 2-Amino-7-(3-methyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56540 Purine nucleoside phosphorylase Bos taurus 3.3 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048046&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646015 103978579 CHEMBL56540 ZINC13798477 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137190 Nc1nc2nc(N)[nH]c(=O)c2[nH]1 InChI=1S/C5H6N6O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H6,6,7,8,9,10,11,12) WYDKPTZGVLTYPG-UHFFFAOYSA-N 50022243 2,8-Diamino-1,9-dihydro-purin-6-one::8-AMINOGUANINE::CHEMBL8040 Purine nucleoside phosphorylase Bos taurus 2299 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022243&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 95201 103932866 CHEMBL8040 ZINC13514984 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137191 Nc1nc2c(CC3CCCC(C3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H17F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h6-7,9,19H,1-5H2,(H3,18,20,21,22) SBRMCLIMRSOKFU-UHFFFAOYSA-N 50048053 2-Amino-7-(3-trifluoromethyl-cyclohexylmethyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL55454 Purine nucleoside phosphorylase Bos taurus 14.8 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048053&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646016 103978586 CHEMBL55454 ZINC13798462 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137192 Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H](CC(O)=O)c1cccc(Cl)c1 InChI=1S/C15H13ClN4O3/c16-8-3-1-2-7(4-8)9(5-11(21)22)10-6-18-13-12(10)19-15(17)20-14(13)23/h1-4,6,9,18H,5H2,(H,21,22)(H3,17,19,20,23)/t9-/m0/s1 YDWZQOZLILLLMU-VIFPVBQESA-N 50078452 (S)-3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionic acid::CHEMBL309907 Purine nucleoside phosphorylase Bos taurus 35.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078452&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 192298 103971003 CHEMBL309907 ZINC21290085 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137193 Nc1nc2c(c[nH]c2c(=O)[nH]1)C1=CCCCC1 InChI=1S/C12H14N4O/c13-12-15-9-8(7-4-2-1-3-5-7)6-14-10(9)11(17)16-12/h4,6,14H,1-3,5H2,(H3,13,15,16,17) VWZFXCVUFKBULH-UHFFFAOYSA-N 50048050 2-Amino-7-cyclohex-1-enyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL301203 Purine nucleoside phosphorylase Bos taurus 500.3 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048050&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646025 103978583 CHEMBL301203 ZINC13798508 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137194 Nc1nc2c(Cc3ccccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-4-2-1-3-7(9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UJAUASVSBLUQKK-UHFFFAOYSA-N 50046253 2-Amino-7-(2-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81966 Purine nucleoside phosphorylase Bos taurus 65 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046253&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10333581 103977075 CHEMBL81966 ZINC13798442 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137195 Nc1nc2c(Cc3ccncc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(5-7-1-3-14-4-2-7)6-15-10(9)11(18)17-12/h1-4,6,15H,5H2,(H3,13,16,17,18) MABQSTXKBLIFAR-UHFFFAOYSA-N 50078453 2-Amino-7-pyridin-4-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-4-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL79865 Purine nucleoside phosphorylase Bos taurus 63.5 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078453&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15115445 103971004 CHEMBL79865 ZINC13798513 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137196 Nc1nc2c(Cc3ccc(O)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-1-3-9(18)4-2-7/h1-4,6,15,18H,5H2,(H3,14,16,17,19) PZTAPFWQMIZJNG-UHFFFAOYSA-N 50046220 2-Amino-7-(4-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81731 Purine nucleoside phosphorylase Bos taurus 238.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046220&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10106443 103977042 CHEMBL81731 ZINC13798448 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137197 CC(C)c1ccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)cc1 InChI=1S/C16H18N4O/c1-9(2)11-5-3-10(4-6-11)7-12-8-18-14-13(12)19-16(17)20-15(14)21/h3-6,8-9,18H,7H2,1-2H3,(H3,17,19,20,21) YNFSXUMIKXWTHB-UHFFFAOYSA-N 50078460 2-Amino-7-(4-isopropyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(4-isopropylbenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL82551 Purine nucleoside phosphorylase Bos taurus 96.6 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50078460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50078460&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10660548 103971011 CHEMBL82551 ZINC13798536 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137198 Nc1nc2c(CC3CCCC3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H16N4O/c13-12-15-9-8(5-7-3-1-2-4-7)6-14-10(9)11(17)16-12/h6-7,14H,1-5H2,(H3,13,15,16,17) YFJGSWQEEMSQEI-UHFFFAOYSA-N 50039562 2-Amino-7-cyclopentylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL56593 Purine nucleoside phosphorylase Bos taurus 20.2 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039562&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 15646012 103946759 CHEMBL56593 ZINC13738105 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137199 O=c1[nH]cnc2c(Cc3ccccc3)c[nH]c12 InChI=1S/C13H11N3O/c17-13-12-11(15-8-16-13)10(7-14-12)6-9-4-2-1-3-5-9/h1-5,7-8,14H,6H2,(H,15,16,17) XTZNEYRTGZTVGE-UHFFFAOYSA-N 50039548 7-Benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81055 Purine nucleoside phosphorylase Bos taurus 5.4 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039548&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10353609 103946745 CHEMBL81055 ZINC00006234 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137200 Nc1nc2c(Cc3cccc(O)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)4-7-2-1-3-9(18)5-7/h1-3,5-6,15,18H,4H2,(H3,14,16,17,19) KFEIVJHPUHYGLV-UHFFFAOYSA-N 50046213 2-Amino-7-(3-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL82087 Purine nucleoside phosphorylase Bos taurus 1.7 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046213&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10467587 103977035 CHEMBL82087 ZINC13798445 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137201 Nc1nc2c(Cc3ccc(Cl)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UUGHFFUUNJFXJA-UHFFFAOYSA-N 50046219 2-Amino-7-(4-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79410 Purine nucleoside phosphorylase Bos taurus 3.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046219&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778126 103977041 CHEMBL79410 ZINC13798437 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50137202 Nc1nc2c(c[nH]c2c(=O)[nH]1)C(CC#N)c1cccc(Cl)c1 InChI=1S/C15H12ClN5O/c16-9-3-1-2-8(6-9)10(4-5-17)11-7-19-13-12(11)20-15(18)21-14(13)22/h1-3,6-7,10,19H,4H2,(H3,18,20,21,22) OHFLESATPONDTK-UHFFFAOYSA-N 50039549 3-(2-Amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-3-(3-chloro-phenyl)-propionitrile::CHEMBL81839 Purine nucleoside phosphorylase Bos taurus 10.9 ChEMBL 10.1021/jm990037y 10.7270/Q2CR5SKN 10395483 Farutin, V; Masterson, L; Andricopulo, AD; Cheng, J; Riley, B; Hakimi, R; Frazer, JW; Cordes, EH University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039549&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 19692440 103946746 CHEMBL81839 ZINC13738104 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50222367 OC[C@H]1NC([C@@H](O)[C@H]1O)c1c[nH]c2c1nc[nH]c2=O InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7?,9+,10-/m1/s1 IWKXDMQDITUYRK-IXCOQTBNSA-N 50122726 2-Hydroxymethyl-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-pyrrolidine-3,4-diol::CHEMBL288187 Purine nucleoside phosphorylase Bos taurus 0.023 ChEMBL 10.1021/jm0203332 10.7270/Q2DF6QJZ 12502369 Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122726&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44287537 104015366 CHEMBL288187 ZINC29333045 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50222369 NC(=O)c1[nH]nc(C2N[C@H](CO)[C@H](O)[C@@H]2O)c1N InChI=1S/C9H15N5O4/c10-3-4(13-14-5(3)9(11)18)6-8(17)7(16)2(1-15)12-6/h2,6-8,12,15-17H,1,10H2,(H2,11,18)(H,13,14)/t2-,6?,7+,8-/m1/s1 OCJZNDIBMCCZDH-KTRJNWGBSA-N 50122724 4-Amino-5-(3,4-dihydroxy-5-hydroxymethyl-pyrrolidin-2-yl)-2H-pyrazole-3-carboxylic acid amide::CHEMBL41949 Purine nucleoside phosphorylase Bos taurus 0.06 ChEMBL 10.1021/jm0203332 10.7270/Q2DF6QJZ 12502369 Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122724&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44287558 104015364 CHEMBL41949 ZINC29340090 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50389093 Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18) JANQQPWTLXUSCD-UHFFFAOYSA-N 50214705 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate::9-(5',5'-difluoro-5'-phosphonopentyl)guanine::9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE::CHEMBL236708::[5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid Purine nucleoside phosphorylase Bos taurus 18.7 ChEMBL 10.1016/j.bmcl.2007.05.054 10.7270/Q29P31CS 17544667 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214705&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search HA1 1V48 448999 104089652 CHEMBL236708 DB04260 ZINC03799963 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50389095 Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18) OISKFAFOKMNXNK-UHFFFAOYSA-N 50214707 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine::CHEMBL236709 Purine nucleoside phosphorylase Bos taurus 10.2 ChEMBL 10.1016/j.bmcl.2007.05.054 10.7270/Q29P31CS 17544667 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214707&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9D9 3FUC 23656706 104089654 CHEMBL236709 ZINC28823715 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50554051 Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18) JANQQPWTLXUSCD-UHFFFAOYSA-N 50214705 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate::9-(5',5'-difluoro-5'-phosphonopentyl)guanine::9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE::CHEMBL236708::[5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid Purine nucleoside phosphorylase Bos taurus 18.7 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214705&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search HA1 1V48 448999 104089652 CHEMBL236708 DB04260 ZINC03799963 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50554052 Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18) OISKFAFOKMNXNK-UHFFFAOYSA-N 50214707 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine::CHEMBL236709 Purine nucleoside phosphorylase Bos taurus 10.2 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214707&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9D9 3FUC 23656706 104089654 CHEMBL236709 ZINC28823715 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50554053 CCOP(=O)(OCC)C(F)(F)CCCCCc1c[nH]c2c1nc(N)[nH]c2=O InChI=1S/C16H25F2N4O4P/c1-3-25-27(24,26-4-2)16(17,18)9-7-5-6-8-11-10-20-13-12(11)21-15(19)22-14(13)23/h10,20H,3-9H2,1-2H3,(H3,19,21,22,23) GYXAXLLQFNASIO-UHFFFAOYSA-N 50308521 9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-deazaguanine::CHEMBL600664 Purine nucleoside phosphorylase Bos taurus 10.2 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308521&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 46229130 104162882 CHEMBL600664 ZINC45369504 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50554054 CCOP(=O)(OCC)C(F)(F)CCCCCCc1c[nH]c2c1nc(N)[nH]c2=O InChI=1S/C17H27F2N4O4P/c1-3-26-28(25,27-4-2)17(18,19)10-8-6-5-7-9-12-11-21-14-13(12)22-16(20)23-15(14)24/h11,21H,3-10H2,1-2H3,(H3,20,22,23,24) YQNJUMKKHIZTJF-UHFFFAOYSA-N 50308522 9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-deazaguanine::CHEMBL591019 Purine nucleoside phosphorylase Bos taurus 42 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308522&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 46229131 104162883 CHEMBL591019 ZINC45335440 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961457 OP(O)(=O)C(F)(F)C[C@@H]1CCOC[C@@H]1Cn1cnc2c1nc[nH]c2=O InChI=1S/C13H17F2N4O5P/c14-13(15,25(21,22)23)3-8-1-2-24-5-9(8)4-19-7-18-10-11(19)16-6-17-12(10)20/h6-9H,1-5H2,(H,16,17,20)(H2,21,22,23)/t8-,9-/m0/s1 JNIMYYSKDBUOIP-IUCAKERBSA-N 50394443 CHEMBL2159650 Purine nucleoside phosphorylase Bos taurus 63 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394443&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 71456799 163343467 CHEMBL2159650 ZINC95575573 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961458 Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18) OISKFAFOKMNXNK-UHFFFAOYSA-N 50214707 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine::CHEMBL236709 Purine nucleoside phosphorylase Bos taurus 6.9 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214707&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9D9 3FUC 23656706 104089654 CHEMBL236709 ZINC28823715 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961459 OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1 IWKXDMQDITUYRK-KUBHLMPHSA-N 50195587 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL::7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL1213652::CHEMBL218291::Immucillin-H Purine nucleoside phosphorylase Bos taurus 0.023 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195587&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search IMH 2Q7O,3MB8,1RR6,1G2O,2ON6,2FF2,1B8O,6ZK5,6ZK2,2FF1,1NW4,1RT9,3B9G,8DB8,3FOW,1PF7,2OC9,2OC4 444499 104077585 43362 CHEMBL1213652CHEMBL218291 ZINC13492899 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961460 Nc1nc2c(CNCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)1-2-14-3-5-4-15-7-6(5)16-9(13)17-8(7)18/h4,14-15H,1-3H2,(H2,19,20,21)(H3,13,16,17,18) UVBFLYNBKQWDQZ-UHFFFAOYSA-N 50394444 CHEMBL2159649 Purine nucleoside phosphorylase Bos taurus 3.6 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394444&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 71462189 163343468 CHEMBL2159649 ZINC95580582 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961461 Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18) OISKFAFOKMNXNK-UHFFFAOYSA-N 50214707 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine::CHEMBL236709 Purine nucleoside phosphorylase Bos taurus 0.1 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214707&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9D9 3FUC 23656706 104089654 CHEMBL236709 ZINC28823715 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961462 Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18) JANQQPWTLXUSCD-UHFFFAOYSA-N 50214705 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate::9-(5',5'-difluoro-5'-phosphonopentyl)guanine::9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE::CHEMBL236708::[5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid Purine nucleoside phosphorylase Bos taurus 0.46 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214705&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search HA1 1V48 448999 104089652 CHEMBL236708 DB04260 ZINC03799963 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961463 Nc1nc2cc[nH]c2c(=O)[nH]1 InChI=1S/C6H6N4O/c7-6-9-3-1-2-8-4(3)5(11)10-6/h1-2,8H,(H3,7,9,10,11) FFYPRJYSJODFFD-UHFFFAOYSA-N 50108005 2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::9-DEAZAGUANINE::CHEMBL367746 Purine nucleoside phosphorylase Bos taurus 170 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50108005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50108005&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9DG 1Q2R,1Q2S,6D9R,7NQ4,1IL4,1FSG 100684 104003233 CHEMBL367746 ZINC18102838 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961464 Nc1nc2cc[nH]c2c(=O)[nH]1 InChI=1S/C6H6N4O/c7-6-9-3-1-2-8-4(3)5(11)10-6/h1-2,8H,(H3,7,9,10,11) FFYPRJYSJODFFD-UHFFFAOYSA-N 50108005 2-Amino-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::9-DEAZAGUANINE::CHEMBL367746 Purine nucleoside phosphorylase Bos taurus 160 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50108005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50108005&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9DG 1Q2R,1Q2S,6D9R,7NQ4,1IL4,1FSG 100684 104003233 CHEMBL367746 ZINC18102838 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961465 Nc1nc2nc[nH]c2c(=O)[nH]1 InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) UYTPUPDQBNUYGX-UHFFFAOYSA-N 50200094 2-amino-1,9-dihydro-6H-purin-6-one::CHEMBL219568::Gua::guanine Purine nucleoside phosphorylase Bos taurus 160 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50200094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50200094&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 764 104080533 30755 CHEMBL219568 4556 ZINC00895129 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961466 Nc1nc2nc[nH]c2c(=O)[nH]1 InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) UYTPUPDQBNUYGX-UHFFFAOYSA-N 50200094 2-amino-1,9-dihydro-6H-purin-6-one::CHEMBL219568::Gua::guanine Purine nucleoside phosphorylase Bos taurus 120 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50200094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50200094&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 764 104080533 30755 CHEMBL219568 4556 ZINC00895129 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50961467 O=c1[nH]cnc2nc[nH]c12 InChI=1S/C5H2N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H UYLWKSJTHLRFBX-UHFFFAOYSA-N 82018 CAS_790::CHEMBL1427::Hypoxanthine::NSC_790 Purine nucleoside phosphorylase Bos taurus 680 ChEMBL 10.1016/j.bmc.2012.08.045 10.7270/Q23N24H7 23040896 Wielgus-Kutrowska, B; Breer, K; Hashimoto, M; Hikishima, S; Yokomatsu, T; Narczyk, M; Dyzma, A; Girstun, A; Staron, K; Bzowska, A University of Warsaw http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82018&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search HPA 2W55,2EES,2EET,2EEU,2EEV,2EEW,1ZAY,1PNR,4NYD,1BDI,1BDH,5MX4,1JFS,1JFT,6HGQ,1VPW,6II7,3ENZ,1VFN,4FEL,4FEN,4FEJ,4FE5,3OZF,3OZB,2PUD,2PUG,1A9Q,1A9T,3SCZ,3LBA,3PAN,4DAB,5MX6,3NRZ,2W3R,5C7W,5C7U,1QQA,1QQB,5IFK,1JH9,1QPZ,1QP7,1QP4,1QP0,3FNQ,1A9R,5TBU,5MX8,4UC0 790 131342592 17368 CHEMBL1427 4555 ZINC18153302 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51004280 Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18) JANQQPWTLXUSCD-UHFFFAOYSA-N 50214705 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate::9-(5',5'-difluoro-5'-phosphonopentyl)guanine::9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE::CHEMBL236708::[5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid Purine nucleoside phosphorylase Bos taurus 2.7 ChEMBL 10.1016/j.bmcl.2007.05.054 10.7270/Q29P31CS 17544667 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214705&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search HA1 1V48 448999 104089652 CHEMBL236708 DB04260 ZINC03799963 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51004282 Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18) OISKFAFOKMNXNK-UHFFFAOYSA-N 50214707 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine::CHEMBL236709 Purine nucleoside phosphorylase Bos taurus 1 ChEMBL 10.1016/j.bmcl.2007.05.054 10.7270/Q29P31CS 17544667 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214707&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9D9 3FUC 23656706 104089654 CHEMBL236709 ZINC28823715 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51004283 Nc1nc2c(CCCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C12H17F2N4O4P/c13-12(14,23(20,21)22)5-3-1-2-4-7-6-16-9-8(7)17-11(15)18-10(9)19/h6,16H,1-5H2,(H2,20,21,22)(H3,15,17,18,19) OUWQMLDMMGTQER-UHFFFAOYSA-N 50214708 6-(2-amino-4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)-1,1-difluorohexylphosphonic acid::CHEMBL236711 Purine nucleoside phosphorylase Bos taurus 5.7 ChEMBL 10.1016/j.bmcl.2007.05.054 10.7270/Q29P31CS 17544667 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214708&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44433096 104089655 CHEMBL236711 ZINC28823717 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51033072 OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1[nH]nc2c1nc[nH]c2=O InChI=1S/C10H13N5O4/c16-1-3-8(17)9(18)6(13-3)5-4-7(15-14-5)10(19)12-2-11-4/h2-3,6,8-9,13,16-18H,1H2,(H,14,15)(H,11,12,19)/t3-,6+,8-,9+/m1/s1 UMACXNRGXRACLJ-PRMBHOGLSA-N 50422435 CHEMBL2311112 Purine nucleoside phosphorylase Bos taurus 0.042000 ChEMBL 10.1021/jm0203332 10.7270/Q2DF6QJZ 12502369 Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422435&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10967479 164151310 CHEMBL2311112 ZINC13525022 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51033074 Nc1nc2c(c[nH]c2c(=O)[nH]1)[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O InChI=1S/C11H15N5O4/c12-11-15-5-3(1-13-7(5)10(20)16-11)6-9(19)8(18)4(2-17)14-6/h1,4,6,8-9,13-14,17-19H,2H2,(H3,12,15,16,20)/t4-,6+,8-,9+/m1/s1 KBIDJCVAURJXFG-PVEDRDFWSA-N 50293086 (1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-D-ribitol::1,4-DIDEOXY-1,4-IMINO-1-(S)-(9-DEAZAGUANIN-9-YL)-D-RIBITOL::2-amino-7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL473922::immucillin G Purine nucleoside phosphorylase Bos taurus 0.030000 ChEMBL 10.1021/jm0203332 10.7270/Q2DF6QJZ 12502369 Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC Industrial Research Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293086&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search IMG 1B8N,1DQP 444498 104134637 43467 CHEMBL473922 ZINC13525011 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014533 Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18) OISKFAFOKMNXNK-UHFFFAOYSA-N 50214707 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine::CHEMBL236709 Purine nucleoside phosphorylase Bos taurus 4.4 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214707&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9D9 3FUC 23656706 104089654 CHEMBL236709 ZINC28823715 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014534 CCOP(=O)(OCC)C(F)(F)CCCCCc1c[nH]c2c1nc(N)[nH]c2=O InChI=1S/C16H25F2N4O4P/c1-3-25-27(24,26-4-2)16(17,18)9-7-5-6-8-11-10-20-13-12(11)21-15(19)22-14(13)23/h10,20H,3-9H2,1-2H3,(H3,19,21,22,23) GYXAXLLQFNASIO-UHFFFAOYSA-N 50308521 9-[6',6'-Difluoro-6'-(diethylphosphono)hexyl]-9-deazaguanine::CHEMBL600664 Purine nucleoside phosphorylase Bos taurus 5.7 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308521&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 46229130 104162882 CHEMBL600664 ZINC45369504 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014535 CCOP(=O)(OCC)C(F)(F)CCCCCCc1c[nH]c2c1nc(N)[nH]c2=O InChI=1S/C17H27F2N4O4P/c1-3-26-28(25,27-4-2)17(18,19)10-8-6-5-7-9-12-11-21-14-13(12)22-16(20)23-15(14)24/h11,21H,3-10H2,1-2H3,(H3,20,22,23,24) YQNJUMKKHIZTJF-UHFFFAOYSA-N 50308522 9-[7',7'-Difluoro-7'-(diethylphosphono)heptyl]-9-deazaguanine::CHEMBL591019 Purine nucleoside phosphorylase Bos taurus 21 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308522&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 46229131 104162883 CHEMBL591019 ZINC45335440 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014536 CCOP(=O)(OCC)C(F)(F)CCCCCCCc1c[nH]c2c1nc(N)[nH]c2=O InChI=1S/C18H29F2N4O4P/c1-3-27-29(26,28-4-2)18(19,20)11-9-7-5-6-8-10-13-12-22-15-14(13)23-17(21)24-16(15)25/h12,22H,3-11H2,1-2H3,(H3,21,23,24,25) ZZPPPMLAIPJXSY-UHFFFAOYSA-N 50415479 CHEMBL601619 Purine nucleoside phosphorylase Bos taurus 6.1 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415479&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 46229132 163364503 CHEMBL601619 ZINC45372629 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014537 Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18) JANQQPWTLXUSCD-UHFFFAOYSA-N 50214705 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate::9-(5',5'-difluoro-5'-phosphonopentyl)guanine::9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE::CHEMBL236708::[5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid Purine nucleoside phosphorylase Bos taurus 2.7 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214705&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search HA1 1V48 448999 104089652 CHEMBL236708 DB04260 ZINC03799963 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014538 Nc1nc2c(CCCCC(F)(F)P(O)(O)=O)c[nH]c2c(=O)[nH]1 InChI=1S/C11H15F2N4O4P/c12-11(13,22(19,20)21)4-2-1-3-6-5-15-8-7(6)16-10(14)17-9(8)18/h5,15H,1-4H2,(H2,19,20,21)(H3,14,16,17,18) OISKFAFOKMNXNK-UHFFFAOYSA-N 50214707 9-(5',5'-Difluoro-5'-phosphonopentyl)-9-deazaguanine::CHEMBL236709 Purine nucleoside phosphorylase Bos taurus 1 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214707&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9D9 3FUC 23656706 104089654 CHEMBL236709 ZINC28823715 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014539 OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1 IWKXDMQDITUYRK-KUBHLMPHSA-N 50195587 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL::7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL1213652::CHEMBL218291::Immucillin-H Purine nucleoside phosphorylase Bos taurus 41 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195587&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search IMH 2Q7O,3MB8,1RR6,1G2O,2ON6,2FF2,1B8O,6ZK5,6ZK2,2FF1,1NW4,1RT9,3B9G,8DB8,3FOW,1PF7,2OC9,2OC4 444499 104077585 43362 CHEMBL1213652CHEMBL218291 ZINC13492899 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014546 CCOP(=O)(OCC)C(F)(F)CCCCCCCc1c[nH]c2c1nc(N)[nH]c2=O InChI=1S/C18H29F2N4O4P/c1-3-27-29(26,28-4-2)18(19,20)11-9-7-5-6-8-10-13-12-22-15-14(13)23-17(21)24-16(15)25/h12,22H,3-11H2,1-2H3,(H3,21,23,24,25) ZZPPPMLAIPJXSY-UHFFFAOYSA-N 50415479 CHEMBL601619 Purine nucleoside phosphorylase Bos taurus 6.10 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415479&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 46229132 163364503 CHEMBL601619 ZINC45372629 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 51014547 Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 InChI=1S/C10H14F2N5O4P/c11-10(12,22(19,20)21)3-1-2-4-17-5-14-6-7(17)15-9(13)16-8(6)18/h5H,1-4H2,(H2,19,20,21)(H3,13,15,16,18) JANQQPWTLXUSCD-UHFFFAOYSA-N 50214705 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate::9-(5',5'-difluoro-5'-phosphonopentyl)guanine::9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE::CHEMBL236708::[5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid Purine nucleoside phosphorylase Bos taurus 6.9 ChEMBL 10.1016/j.bmc.2010.01.062 10.7270/Q2N58MG0 20189401 Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Tokyo University of Pharmacy and Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214705&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search HA1 1V48 448999 104089652 CHEMBL236708 DB04260 ZINC03799963 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059464 Nc1nc2c(Cc3cccc(O)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)4-7-2-1-3-9(18)5-7/h1-3,5-6,15,18H,4H2,(H3,14,16,17,19) KFEIVJHPUHYGLV-UHFFFAOYSA-N 50046213 2-Amino-7-(3-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL82087 Purine nucleoside phosphorylase Bos taurus 274 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046213&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10467587 103977035 CHEMBL82087 ZINC13798445 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059469 Nc1nc2c(Cc3ccc(Cl)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UUGHFFUUNJFXJA-UHFFFAOYSA-N 50046219 2-Amino-7-(4-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79410 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046219&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778126 103977041 CHEMBL79410 ZINC13798437 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059470 Nc1nc2c(Cc3ccco3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4O2/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) YABIPPNOXRKWBX-UHFFFAOYSA-N 50046240 2-Amino-7-furan-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351205 Purine nucleoside phosphorylase Bos taurus 83 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046240&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11776004 103977062 CHEMBL351205 ZINC13861147 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059474 Nc1nc2c(Cc3cccc(c3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H11F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h1-3,5-6,19H,4H2,(H3,18,20,21,22) CBTABLJYKHBPFF-UHFFFAOYSA-N 50046232 2-Amino-7-(3-trifluoromethyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL354926 Purine nucleoside phosphorylase Bos taurus 190 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046232&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10040910 103977054 CHEMBL354926 ZINC13861144 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059475 Nc1nc2C(Cc3ccsc3)CNc2c(=O)[nH]1 InChI=1S/C11H12N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,5,7,13H,3-4H2,(H3,12,14,15,16) SKEKJWCUZBODGF-UHFFFAOYSA-N 50046239 2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159640 Purine nucleoside phosphorylase Bos taurus 0.067000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046239&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929345 103977061 CHEMBL159640 ZINC27757076 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059477 COc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O2/c1-20-10-4-2-3-8(6-10)5-9-7-16-12-11(9)17-14(15)18-13(12)19/h2-4,6-7,16H,5H2,1H3,(H3,15,17,18,19) DOQAZHCUONJLMW-UHFFFAOYSA-N 50046214 2-Amino-7-(3-methoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL162751 Purine nucleoside phosphorylase Bos taurus 82 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046214&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10400926 103977036 CHEMBL162751 ZINC13861146 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059480 Nc1nc2c(Cc3ccc(I)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11IN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) GFFQSWANLMANPJ-UHFFFAOYSA-N 50046245 2-Amino-7-(4-iodo-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL349615 Purine nucleoside phosphorylase Bos taurus 23 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046245&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10316804 103977067 CHEMBL349615 ZINC13861142 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059482 Nc1nc2c(Cc3ccc(O)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-1-3-9(18)4-2-7/h1-4,6,15,18H,5H2,(H3,14,16,17,19) PZTAPFWQMIZJNG-UHFFFAOYSA-N 50046220 2-Amino-7-(4-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81731 Purine nucleoside phosphorylase Bos taurus 260 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046220&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10106443 103977042 CHEMBL81731 ZINC13798448 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059483 Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QDPMHXUWMPNTEQ-UHFFFAOYSA-N 50039544 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79784 Purine nucleoside phosphorylase Bos taurus 80 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039544&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 3035609 103946742 CHEMBL79784 ZINC00005543 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059485 Nc1nc2C(Cc3ccccc3)CNc2c(=O)[nH]1 InChI=1S/C13H14N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,9,15H,6-7H2,(H3,14,16,17,18) SRZKQXMAAAAYDI-UHFFFAOYSA-N 50046234 2-Amino-7-benzyl-3,4a,5,7a-tetrahydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL161609 Purine nucleoside phosphorylase Bos taurus 12 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046234&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929343 103977056 CHEMBL161609 ZINC49925405 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059486 Nc1nc2c(Cc3ccccc3O)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-3-1-2-4-9(7)18/h1-4,6,15,18H,5H2,(H3,14,16,17,19) RQCPZIFPORZYES-UHFFFAOYSA-N 50046237 2-Amino-7-(2-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL309679 Purine nucleoside phosphorylase Bos taurus 270 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046237&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11777160 103977059 CHEMBL309679 ZINC13798502 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059487 Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18) ZBEJFMQAPZKPCM-UHFFFAOYSA-N 50039547 2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310202 Purine nucleoside phosphorylase Bos taurus 210 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039547&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9881238 103946744 CHEMBL310202 ZINC00005887 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074818 Nc1nc2c(Cc3ccccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-4-2-1-3-7(9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UJAUASVSBLUQKK-UHFFFAOYSA-N 50046253 2-Amino-7-(2-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81966 Purine nucleoside phosphorylase Bos taurus 120 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046253&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10333581 103977075 CHEMBL81966 ZINC13798442 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074819 NC1Nc2c(nc(N)[nH]c2=O)N1Cc1cccs1 InChI=1S/C10H12N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3,10,13H,4,12H2,(H3,11,14,15,17) QBNDMLFHVRRQSV-UHFFFAOYSA-N 50046215 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL162255 Purine nucleoside phosphorylase Bos taurus 90 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046215&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374597 103977037 CHEMBL162255 ZINC27746940 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074826 Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h1-3,5-6,15H,4H2,(H3,13,16,17,18) DOHVAKFYAHLCJP-UHFFFAOYSA-N 50039542 2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL311300 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039542&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search BC3 3DJF 60817 103946740 CHEMBL311300 ZINC05420970 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074827 Nc1nc2c(Cc3ccc(Cl)c(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H10Cl2N4O/c14-8-2-1-6(4-9(8)15)3-7-5-17-11-10(7)18-13(16)19-12(11)20/h1-2,4-5,17H,3H2,(H3,16,18,19,20) FVPGRDMKNFHMAJ-UHFFFAOYSA-N 50046225 2-Amino-7-(3,4-dichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL160043 Purine nucleoside phosphorylase Bos taurus 250 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046225&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10063910 103977047 CHEMBL160043 ZINC13861140 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074839 Nc1nc2c(Cc3cc(Cl)cc(Cl)c3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H9Cl3N4O/c14-7-2-5(9(16)8(15)3-7)1-6-4-18-11-10(6)19-13(17)20-12(11)21/h2-4,18H,1H2,(H3,17,19,20,21) RZCKSKZVJBTDGA-UHFFFAOYSA-N 50046228 2-Amino-7-(2,3,5-trichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL158599 Purine nucleoside phosphorylase Bos taurus 10000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046228&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11725010 103977050 CHEMBL158599 ZINC13861148 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074844 Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3H,4H2,(H2,12,13)(H3,11,14,15,17) HANOSGYMKMNFON-UHFFFAOYSA-N 50005795 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL285627::PD-119229-2 Purine nucleoside phosphorylase Bos taurus 160 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005795&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 147062 103919220 CHEMBL285627 ZINC06093612 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074854 NC1Nc2c(nc(N)[nH]c2=O)N1Cc1cccs1 InChI=1S/C10H12N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3,10,13H,4,12H2,(H3,11,14,15,17) QBNDMLFHVRRQSV-UHFFFAOYSA-N 50046215 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL162255 Purine nucleoside phosphorylase Bos taurus 45 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046215&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374597 103977037 CHEMBL162255 ZINC27746940 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074858 Nc1nc2c(Cc3cccc(F)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11FN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) WOWBUNTUMYSYSI-UHFFFAOYSA-N 50046233 2-Amino-7-(3-fluoro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159908 Purine nucleoside phosphorylase Bos taurus 24 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046233&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10061045 103977055 CHEMBL159908 ZINC13861143 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074860 Nc1nc2c(Cc3cccc(Oc4ccccc4)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C19H16N4O2/c20-19-22-16-13(11-21-17(16)18(24)23-19)9-12-5-4-8-15(10-12)25-14-6-2-1-3-7-14/h1-8,10-11,21H,9H2,(H3,20,22,23,24) SZLVNGWVKLCDQQ-UHFFFAOYSA-N 50046244 2-Amino-7-(3-phenoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159471 Purine nucleoside phosphorylase Bos taurus 740 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046244&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374526 103977066 CHEMBL159471 ZINC27753733 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074861 Nc1nc2c(Cc3cccs3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) FJABJEFAQUFECU-UHFFFAOYSA-N 50046242 2-Amino-7-thiophen-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351815 Purine nucleoside phosphorylase Bos taurus 21 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046242&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10083264 103977064 CHEMBL351815 ZINC13861141 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074869 Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) CULKYGOMWFATON-UHFFFAOYSA-N 50042804 2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(3-chlorobenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310364 Purine nucleoside phosphorylase Bos taurus 20 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042804&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778127 103974369 CHEMBL310364 ZINC13798439 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074871 Cc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h2-5,7,16H,6H2,1H3,(H3,15,17,18,19) ICFRYSRRTZTEHG-UHFFFAOYSA-N 50046222 2-Amino-7-(3-methyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159960 Purine nucleoside phosphorylase Bos taurus 270 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046222&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10060867 103977044 CHEMBL159960 ZINC13861145 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074874 Nc1nc2N(Cc3cccs3)CNc2c(=O)[nH]1 InChI=1S/C10H11N5OS/c11-10-13-8-7(9(16)14-10)12-5-15(8)4-6-2-1-3-17-6/h1-3,12H,4-5H2,(H3,11,13,14,16) UPNZQUYQZWHTQQ-UHFFFAOYSA-N 50046226 2-Amino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL345655 Purine nucleoside phosphorylase Bos taurus 11 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE BioCryst Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046226&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374593 103977048 CHEMBL345655 ZINC27761709 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2